Molecular Imaging in the College of Optical Sciences – An Overview of Two Decades of Instrumentation Development
Identifieur interne : 003587 ( Pmc/Curation ); précédent : 003586; suivant : 003588Molecular Imaging in the College of Optical Sciences – An Overview of Two Decades of Instrumentation Development
Auteurs : Lars R. Furenlid [États-Unis] ; Harrison H. Barrett [États-Unis] ; H. Bradford Barber [États-Unis] ; Eric W. Clarkson [États-Unis] ; Matthew A. Kupinski [États-Unis] ; Zhonglin Liu [États-Unis] ; Gail D. Stevenson [États-Unis] ; James M. Woolfenden [États-Unis]Source :
- Proceedings of SPIE--the International Society for Optical Engineering [ 0277-786X ] ; 2014.
Abstract
During the past two decades, researchers at the University of Arizona’s Center for Gamma-Ray Imaging (CGRI) have explored a variety of approaches to gamma-ray detection, including scintillation cameras, solid-state detectors, and hybrids such as the intensified Quantum Imaging Device (iQID) configuration where a scintillator is followed by optical gain and a fast CCD or CMOS camera. We have combined these detectors with a variety of collimation schemes, including single and multiple pinholes, parallel-hole collimators, synthetic apertures, and anamorphic crossed slits, to build a large number of preclinical molecular-imaging systems that perform Single-Photon Emission Computed Tomography (SPECT), Positron Emission Tomography (PET), and X-Ray Computed Tomography (CT). In this paper, we discuss the themes and methods we have developed over the years to record and fully use the information content carried by every detected gamma-ray photon.
Url:
DOI: 10.1117/12.2064808
PubMed: 26236069
PubMed Central: 4520714
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<front><div type="abstract" xml:lang="en"><p id="P1">During the past two decades, researchers at the University of Arizona’s Center for Gamma-Ray Imaging (CGRI) have explored a variety of approaches to gamma-ray detection, including scintillation cameras, solid-state detectors, and hybrids such as the intensified Quantum Imaging Device (iQID) configuration where a scintillator is followed by optical gain and a fast CCD or CMOS camera. We have combined these detectors with a variety of collimation schemes, including single and multiple pinholes, parallel-hole collimators, synthetic apertures, and anamorphic crossed slits, to build a large number of preclinical molecular-imaging systems that perform Single-Photon Emission Computed Tomography (SPECT), Positron Emission Tomography (PET), and X-Ray Computed Tomography (CT). In this paper, we discuss the themes and methods we have developed over the years to record and fully use the information content carried by every detected gamma-ray photon.</p>
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<contrib-group><contrib contrib-type="author"><name><surname>Furenlid</surname>
<given-names>Lars R.</given-names>
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<xref ref-type="aff" rid="A2">b</xref>
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<contrib contrib-type="author"><name><surname>Barrett</surname>
<given-names>Harrison H.</given-names>
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<xref ref-type="aff" rid="A1">a</xref>
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<given-names>Eric W.</given-names>
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<xref ref-type="aff" rid="A1">a</xref>
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<contrib contrib-type="author"><name><surname>Kupinski</surname>
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<given-names>Zhonglin</given-names>
</name>
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<contrib contrib-type="author"><name><surname>Stevenson</surname>
<given-names>Gail D.</given-names>
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<xref ref-type="aff" rid="A2">b</xref>
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<contrib contrib-type="author"><name><surname>Woolfenden</surname>
<given-names>James M.</given-names>
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<aff id="A1"><label>a</label>
College of Optical Sciences, University of Arizona, Tucson, AZ 85721, USA</aff>
<aff id="A2"><label>b</label>
Center for Gamma-Ray Imaging, Dept. of Medical Imaging, University of Arizona, Tucson, AZ 85724, USA</aff>
<author-notes><corresp id="cor1"><label>*</label>
<email>furen@radiology.arizona.edu</email>
; phone: (520)-626-4256</corresp>
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<pub-date pub-type="pmc-release"><day>30</day>
<month>7</month>
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<volume>9186</volume>
<elocation-id>91860J</elocation-id>
<abstract><p id="P1">During the past two decades, researchers at the University of Arizona’s Center for Gamma-Ray Imaging (CGRI) have explored a variety of approaches to gamma-ray detection, including scintillation cameras, solid-state detectors, and hybrids such as the intensified Quantum Imaging Device (iQID) configuration where a scintillator is followed by optical gain and a fast CCD or CMOS camera. We have combined these detectors with a variety of collimation schemes, including single and multiple pinholes, parallel-hole collimators, synthetic apertures, and anamorphic crossed slits, to build a large number of preclinical molecular-imaging systems that perform Single-Photon Emission Computed Tomography (SPECT), Positron Emission Tomography (PET), and X-Ray Computed Tomography (CT). In this paper, we discuss the themes and methods we have developed over the years to record and fully use the information content carried by every detected gamma-ray photon.</p>
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