Molecular Imaging in the College of Optical Sciences – An Overview of Two Decades of Instrumentation Development
Identifieur interne : 003588 ( Pmc/Corpus ); précédent : 003587; suivant : 003589Molecular Imaging in the College of Optical Sciences – An Overview of Two Decades of Instrumentation Development
Auteurs : Lars R. Furenlid ; Harrison H. Barrett ; H. Bradford Barber ; Eric W. Clarkson ; Matthew A. Kupinski ; Zhonglin Liu ; Gail D. Stevenson ; James M. WoolfendenSource :
- Proceedings of SPIE--the International Society for Optical Engineering [ 0277-786X ] ; 2014.
Abstract
During the past two decades, researchers at the University of Arizona’s Center for Gamma-Ray Imaging (CGRI) have explored a variety of approaches to gamma-ray detection, including scintillation cameras, solid-state detectors, and hybrids such as the intensified Quantum Imaging Device (iQID) configuration where a scintillator is followed by optical gain and a fast CCD or CMOS camera. We have combined these detectors with a variety of collimation schemes, including single and multiple pinholes, parallel-hole collimators, synthetic apertures, and anamorphic crossed slits, to build a large number of preclinical molecular-imaging systems that perform Single-Photon Emission Computed Tomography (SPECT), Positron Emission Tomography (PET), and X-Ray Computed Tomography (CT). In this paper, we discuss the themes and methods we have developed over the years to record and fully use the information content carried by every detected gamma-ray photon.
Url:
DOI: 10.1117/12.2064808
PubMed: 26236069
PubMed Central: 4520714
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Barrett</name><affiliation><nlm:aff id="A1">College of Optical Sciences, University of Arizona, Tucson, AZ 85721, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Center for Gamma-Ray Imaging, Dept. of Medical Imaging, University of Arizona, Tucson, AZ 85724, USA</nlm:aff></affiliation></author><author><name sortKey="Barber, H Bradford" sort="Barber, H Bradford" uniqKey="Barber H" first="H. Bradford" last="Barber">H. Bradford Barber</name><affiliation><nlm:aff id="A1">College of Optical Sciences, University of Arizona, Tucson, AZ 85721, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Center for Gamma-Ray Imaging, Dept. of Medical Imaging, University of Arizona, Tucson, AZ 85724, USA</nlm:aff></affiliation></author><author><name sortKey="Clarkson, Eric W" sort="Clarkson, Eric W" uniqKey="Clarkson E" first="Eric W." last="Clarkson">Eric W. Clarkson</name><affiliation><nlm:aff id="A1">College of Optical Sciences, University of Arizona, Tucson, AZ 85721, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Center for Gamma-Ray Imaging, Dept. of Medical Imaging, University of Arizona, Tucson, AZ 85724, USA</nlm:aff></affiliation></author><author><name sortKey="Kupinski, Matthew A" sort="Kupinski, Matthew A" uniqKey="Kupinski M" first="Matthew A." last="Kupinski">Matthew A. Kupinski</name><affiliation><nlm:aff id="A1">College of Optical Sciences, University of Arizona, Tucson, AZ 85721, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Center for Gamma-Ray Imaging, Dept. of Medical Imaging, University of Arizona, Tucson, AZ 85724, USA</nlm:aff></affiliation></author><author><name sortKey="Liu, Zhonglin" sort="Liu, Zhonglin" uniqKey="Liu Z" first="Zhonglin" last="Liu">Zhonglin Liu</name><affiliation><nlm:aff id="A2">Center for Gamma-Ray Imaging, Dept. of Medical Imaging, University of Arizona, Tucson, AZ 85724, USA</nlm:aff></affiliation></author><author><name sortKey="Stevenson, Gail D" sort="Stevenson, Gail D" uniqKey="Stevenson G" first="Gail D." last="Stevenson">Gail D. Stevenson</name><affiliation><nlm:aff id="A2">Center for Gamma-Ray Imaging, Dept. of Medical Imaging, University of Arizona, Tucson, AZ 85724, USA</nlm:aff></affiliation></author><author><name sortKey="Woolfenden, James M" sort="Woolfenden, James M" uniqKey="Woolfenden J" first="James M." last="Woolfenden">James M. Woolfenden</name><affiliation><nlm:aff id="A2">Center for Gamma-Ray Imaging, Dept. of Medical Imaging, University of Arizona, Tucson, AZ 85724, USA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26236069</idno><idno type="pmc">4520714</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520714</idno><idno type="RBID">PMC:4520714</idno><idno type="doi">10.1117/12.2064808</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">003588</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">003588</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Molecular Imaging in the College of Optical Sciences – An Overview of Two Decades of Instrumentation Development</title><author><name sortKey="Furenlid, Lars R" sort="Furenlid, Lars R" uniqKey="Furenlid L" first="Lars R." last="Furenlid">Lars R. Furenlid</name><affiliation><nlm:aff id="A1">College of Optical Sciences, University of Arizona, Tucson, AZ 85721, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Center for Gamma-Ray Imaging, Dept. of Medical Imaging, University of Arizona, Tucson, AZ 85724, USA</nlm:aff></affiliation></author><author><name sortKey="Barrett, Harrison H" sort="Barrett, Harrison H" uniqKey="Barrett H" first="Harrison H." last="Barrett">Harrison H. Barrett</name><affiliation><nlm:aff id="A1">College of Optical Sciences, University of Arizona, Tucson, AZ 85721, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Center for Gamma-Ray Imaging, Dept. of Medical Imaging, University of Arizona, Tucson, AZ 85724, USA</nlm:aff></affiliation></author><author><name sortKey="Barber, H Bradford" sort="Barber, H Bradford" uniqKey="Barber H" first="H. Bradford" last="Barber">H. Bradford Barber</name><affiliation><nlm:aff id="A1">College of Optical Sciences, University of Arizona, Tucson, AZ 85721, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Center for Gamma-Ray Imaging, Dept. of Medical Imaging, University of Arizona, Tucson, AZ 85724, USA</nlm:aff></affiliation></author><author><name sortKey="Clarkson, Eric W" sort="Clarkson, Eric W" uniqKey="Clarkson E" first="Eric W." last="Clarkson">Eric W. Clarkson</name><affiliation><nlm:aff id="A1">College of Optical Sciences, University of Arizona, Tucson, AZ 85721, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Center for Gamma-Ray Imaging, Dept. of Medical Imaging, University of Arizona, Tucson, AZ 85724, USA</nlm:aff></affiliation></author><author><name sortKey="Kupinski, Matthew A" sort="Kupinski, Matthew A" uniqKey="Kupinski M" first="Matthew A." last="Kupinski">Matthew A. Kupinski</name><affiliation><nlm:aff id="A1">College of Optical Sciences, University of Arizona, Tucson, AZ 85721, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Center for Gamma-Ray Imaging, Dept. of Medical Imaging, University of Arizona, Tucson, AZ 85724, USA</nlm:aff></affiliation></author><author><name sortKey="Liu, Zhonglin" sort="Liu, Zhonglin" uniqKey="Liu Z" first="Zhonglin" last="Liu">Zhonglin Liu</name><affiliation><nlm:aff id="A2">Center for Gamma-Ray Imaging, Dept. of Medical Imaging, University of Arizona, Tucson, AZ 85724, USA</nlm:aff></affiliation></author><author><name sortKey="Stevenson, Gail D" sort="Stevenson, Gail D" uniqKey="Stevenson G" first="Gail D." last="Stevenson">Gail D. Stevenson</name><affiliation><nlm:aff id="A2">Center for Gamma-Ray Imaging, Dept. of Medical Imaging, University of Arizona, Tucson, AZ 85724, USA</nlm:aff></affiliation></author><author><name sortKey="Woolfenden, James M" sort="Woolfenden, James M" uniqKey="Woolfenden J" first="James M." last="Woolfenden">James M. Woolfenden</name><affiliation><nlm:aff id="A2">Center for Gamma-Ray Imaging, Dept. of Medical Imaging, University of Arizona, Tucson, AZ 85724, USA</nlm:aff></affiliation></author></analytic><series><title level="j">Proceedings of SPIE--the International Society for Optical Engineering</title><idno type="ISSN">0277-786X</idno><idno type="eISSN">1996-756X</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">During the past two decades, researchers at the University of Arizona’s Center for Gamma-Ray Imaging (CGRI) have explored a variety of approaches to gamma-ray detection, including scintillation cameras, solid-state detectors, and hybrids such as the intensified Quantum Imaging Device (iQID) configuration where a scintillator is followed by optical gain and a fast CCD or CMOS camera. We have combined these detectors with a variety of collimation schemes, including single and multiple pinholes, parallel-hole collimators, synthetic apertures, and anamorphic crossed slits, to build a large number of preclinical molecular-imaging systems that perform Single-Photon Emission Computed Tomography (SPECT), Positron Emission Tomography (PET), and X-Ray Computed Tomography (CT). In this paper, we discuss the themes and methods we have developed over the years to record and fully use the information content carried by every detected gamma-ray photon.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">101524122</journal-id><journal-id journal-id-type="pubmed-jr-id">37467</journal-id><journal-id journal-id-type="nlm-ta">Proc SPIE Int Soc Opt Eng</journal-id><journal-id journal-id-type="iso-abbrev">Proc SPIE Int Soc Opt Eng</journal-id><journal-title-group><journal-title>Proceedings of SPIE--the International Society for Optical Engineering</journal-title></journal-title-group><issn pub-type="ppub">0277-786X</issn><issn pub-type="epub">1996-756X</issn></journal-meta><article-meta><article-id pub-id-type="pmid">26236069</article-id><article-id pub-id-type="pmc">4520714</article-id><article-id pub-id-type="doi">10.1117/12.2064808</article-id><article-id pub-id-type="manuscript">NIHMS708800</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Molecular Imaging in the College of Optical Sciences – An Overview of Two Decades of Instrumentation Development</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Furenlid</surname><given-names>Lars R.</given-names></name><xref ref-type="aff" rid="A1">a</xref><xref ref-type="aff" rid="A2">b</xref><xref ref-type="corresp" rid="cor1">*</xref></contrib><contrib contrib-type="author"><name><surname>Barrett</surname><given-names>Harrison H.</given-names></name><xref ref-type="aff" rid="A1">a</xref><xref ref-type="aff" rid="A2">b</xref></contrib><contrib contrib-type="author"><name><surname>Barber</surname><given-names>H. Bradford</given-names></name><xref ref-type="aff" rid="A1">a</xref><xref ref-type="aff" rid="A2">b</xref></contrib><contrib contrib-type="author"><name><surname>Clarkson</surname><given-names>Eric W.</given-names></name><xref ref-type="aff" rid="A1">a</xref><xref ref-type="aff" rid="A2">b</xref></contrib><contrib contrib-type="author"><name><surname>Kupinski</surname><given-names>Matthew A.</given-names></name><xref ref-type="aff" rid="A1">a</xref><xref ref-type="aff" rid="A2">b</xref></contrib><contrib contrib-type="author"><name><surname>Liu</surname><given-names>Zhonglin</given-names></name><xref ref-type="aff" rid="A2">b</xref></contrib><contrib contrib-type="author"><name><surname>Stevenson</surname><given-names>Gail D.</given-names></name><xref ref-type="aff" rid="A2">b</xref></contrib><contrib contrib-type="author"><name><surname>Woolfenden</surname><given-names>James M.</given-names></name><xref ref-type="aff" rid="A2">b</xref></contrib></contrib-group><aff id="A1"><label>a</label>College of Optical Sciences, University of Arizona, Tucson, AZ 85721, USA</aff><aff id="A2"><label>b</label>Center for Gamma-Ray Imaging, Dept. of Medical Imaging, University of Arizona, Tucson, AZ 85724, USA</aff><author-notes><corresp id="cor1"><label>*</label><email>furen@radiology.arizona.edu</email>; phone: (520)-626-4256</corresp></author-notes><pub-date pub-type="nihms-submitted"><day>22</day><month>7</month><year>2015</year></pub-date><pub-date pub-type="epub"><day>20</day><month>10</month><year>2014</year></pub-date><pub-date pub-type="ppub"><day>17</day><month>8</month><year>2014</year></pub-date><pub-date pub-type="pmc-release"><day>30</day><month>7</month><year>2015</year></pub-date><volume>9186</volume><elocation-id>91860J</elocation-id><abstract><p id="P1">During the past two decades, researchers at the University of Arizona’s Center for Gamma-Ray Imaging (CGRI) have explored a variety of approaches to gamma-ray detection, including scintillation cameras, solid-state detectors, and hybrids such as the intensified Quantum Imaging Device (iQID) configuration where a scintillator is followed by optical gain and a fast CCD or CMOS camera. We have combined these detectors with a variety of collimation schemes, including single and multiple pinholes, parallel-hole collimators, synthetic apertures, and anamorphic crossed slits, to build a large number of preclinical molecular-imaging systems that perform Single-Photon Emission Computed Tomography (SPECT), Positron Emission Tomography (PET), and X-Ray Computed Tomography (CT). In this paper, we discuss the themes and methods we have developed over the years to record and fully use the information content carried by every detected gamma-ray photon.</p></abstract><kwd-group><kwd>molecular imaging</kwd><kwd>instrumentation</kwd><kwd>detectors</kwd><kwd>collimation</kwd><kwd>estimation</kwd><kwd>reconstruction</kwd><kwd>SPECT</kwd><kwd>PET</kwd><kwd>CT</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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