The potential role of podoplanin in tumour invasion
Identifieur interne : 000133 ( Pmc/Curation ); précédent : 000132; suivant : 000134The potential role of podoplanin in tumour invasion
Auteurs : A. Wicki [Suisse] ; G. Christofori [Suisse]Source :
- British Journal of Cancer [ 0007-0920 ] ; 2006.
Abstract
Podoplanin is a small mucin-like transmembrane protein, widely expressed in various specialised cell types throughout the body. Here, we revisit the mechanism of podoplanin-mediated tumour invasion. We compare molecular pathways leading to single and collective cell invasion and discuss novel distinct concepts of tumour cell invasion.
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DOI: 10.1038/sj.bjc.6603518
PubMed: 17179989
PubMed Central: 2360213
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<pmc-comment> Original-type: rv</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Br J Cancer</journal-id><journal-title>British Journal of Cancer</journal-title><issn pub-type="ppub">0007-0920</issn><issn pub-type="epub">1532-1827</issn><publisher><publisher-name>Nature Publishing Group</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">17179989</article-id><article-id pub-id-type="pmc">2360213</article-id><article-id pub-id-type="pii">6603518</article-id><article-id pub-id-type="doi">10.1038/sj.bjc.6603518</article-id><article-categories><subj-group subj-group-type="heading"><subject>Reviews</subject></subj-group></article-categories><title-group><article-title>The potential role of podoplanin in tumour invasion</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Wicki</surname><given-names>A</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Christofori</surname><given-names>G</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="corresp" rid="caf1">*</xref></contrib></contrib-group><aff id="aff1"><label>1</label><institution>Department of Clinical-Biological Sciences, Institute of Biochemistry and Genetics, Centre for Biomedicine, University of Basel, Mattenstrasse 28</institution> CH – 4058 Basel,<country>Switzerland</country></aff><author-notes><corresp id="caf1"><label>*</label>Author for correspondence: <email xlink:href="mailto:gerhard.christofori@unibas.ch">gerhard.christofori@unibas.ch</email></corresp></author-notes><pub-date pub-type="epub"><day>19</day><month>12</month><year>2006</year></pub-date><pub-date pub-type="collection"><day>09</day><month>01</month><year>2007</year></pub-date><pub-date pub-type="ppub"><day>15</day><month>01</month><year>2007</year></pub-date><volume>96</volume><issue>1</issue><fpage>1</fpage><lpage>5</lpage><history><date date-type="received"><day>30</day><month>06</month><year>2006</year></date><date date-type="rev-recd"><day>10</day><month>11</month><year>2006</year></date><date date-type="accepted"><day>10</day><month>11</month><year>2006</year></date></history><copyright-statement>Copyright 2007, Cancer Research UK</copyright-statement><copyright-year>2007</copyright-year><permissions><copyright-holder>Cancer Research UK</copyright-holder></permissions><abstract><p>Podoplanin is a small mucin-like transmembrane protein, widely expressed in various specialised cell types throughout the body. Here, we revisit the mechanism of podoplanin-mediated tumour invasion. We compare molecular pathways leading to single and collective cell invasion and discuss novel distinct concepts of tumour cell invasion.</p></abstract><kwd-group><kwd>cadherin</kwd><kwd>cancer</kwd><kwd>cytoskeleton</kwd><kwd>EMT</kwd><kwd>invasion</kwd><kwd>podoplanin</kwd></kwd-group></article-meta></front><floats-wrap><fig id="fig1"><label>Figure 1</label><caption><p>Human tumour samples stained for E-cadherin (brown) and podoplanin (red) show single cell (<bold>A</bold>) and collective cell invasion (<bold>B</bold>). (<bold>A</bold>) This adenocarcinoma of the colon invades into the surrounding tissue by single cell invasion. Most of the cells of the tumour bulk (TU) express E-cadherin. Single cells invading the tissue (arrows) have downregulated E-cadherin. Podoplanin is not expressed in this cancer. (<bold>B</bold>) An oesophageal carcinoma has formed an invasive cone that migrates into the surrounding tissue. Podoplanin (red) is expressed in the outer edge of the invading tumour. The tumour cells continue to express E-cadherin (brown) and migrate collectively. Size bar=50 <italic>μ</italic>m.</p></caption><graphic mime-subtype="eps" xlink:href="6603518f1"></graphic></fig><fig id="fig2"><label>Figure 2</label><caption><p>Two mechanisms are involved in the progression of an adenoma to a carcinoma: either the tumours undergo EMT, or they do not (non-EMT). In EMT, the expression profile of adhesion molecules, components of the cytoskeleton and transcriptional regulators is changed. Although non-EMT pathways of tumour invasion are less well studied, they also lead to alterations of the cytoskeleton and the adhesive apparatus. In addition, podoplanin and possibly other mucin-like transmembrane proteins are involved.</p></caption><graphic mime-subtype="eps" xlink:href="6603518f2"></graphic></fig></floats-wrap></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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