Repurposing drugs for the treatment and control of helminth infections
Identifieur interne : 004A79 ( Pmc/Corpus ); précédent : 004A78; suivant : 004A80Repurposing drugs for the treatment and control of helminth infections
Auteurs : Gordana Panic ; Urs Duthaler ; Benjamin Speich ; Jennifer KeiserSource :
- International Journal for Parasitology: Drugs and Drug Resistance [ 2211-3207 ] ; 2014.
Abstract
Url:
DOI: 10.1016/j.ijpddr.2014.07.002
PubMed: 25516827
PubMed Central: 4266803
Links to Exploration step
PMC:4266803Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Repurposing drugs for the treatment and control of helminth infections</title><author><name sortKey="Panic, Gordana" sort="Panic, Gordana" uniqKey="Panic G" first="Gordana" last="Panic">Gordana Panic</name></author><author><name sortKey="Duthaler, Urs" sort="Duthaler, Urs" uniqKey="Duthaler U" first="Urs" last="Duthaler">Urs Duthaler</name></author><author><name sortKey="Speich, Benjamin" sort="Speich, Benjamin" uniqKey="Speich B" first="Benjamin" last="Speich">Benjamin Speich</name></author><author><name sortKey="Keiser, Jennifer" sort="Keiser, Jennifer" uniqKey="Keiser J" first="Jennifer" last="Keiser">Jennifer Keiser</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25516827</idno><idno type="pmc">4266803</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266803</idno><idno type="RBID">PMC:4266803</idno><idno type="doi">10.1016/j.ijpddr.2014.07.002</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">004A79</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">004A79</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Repurposing drugs for the treatment and control of helminth infections</title><author><name sortKey="Panic, Gordana" sort="Panic, Gordana" uniqKey="Panic G" first="Gordana" last="Panic">Gordana Panic</name></author><author><name sortKey="Duthaler, Urs" sort="Duthaler, Urs" uniqKey="Duthaler U" first="Urs" last="Duthaler">Urs Duthaler</name></author><author><name sortKey="Speich, Benjamin" sort="Speich, Benjamin" uniqKey="Speich B" first="Benjamin" last="Speich">Benjamin Speich</name></author><author><name sortKey="Keiser, Jennifer" sort="Keiser, Jennifer" uniqKey="Keiser J" first="Jennifer" last="Keiser">Jennifer Keiser</name></author></analytic><series><title level="j">International Journal for Parasitology: Drugs and Drug Resistance</title><idno type="eISSN">2211-3207</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Graphical abstract</title><fig id="f0010" position="anchor"><graphic xlink:href="fx1"></graphic></fig></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Abaza, H" uniqKey="Abaza H">H. Abaza</name></author><author><name sortKey="El Zayadi, A R" uniqKey="El Zayadi A">A.R. El-Zayadi</name></author><author><name sortKey="Kabil, S M" uniqKey="Kabil S">S.M. Kabil</name></author><author><name sortKey="Rizk, H" uniqKey="Rizk H">H. Rizk</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Abdul Ghani, R A" uniqKey="Abdul Ghani R">R.A. Abdul-Ghani</name></author><author><name sortKey="Loutfy, N" uniqKey="Loutfy N">N. Loutfy</name></author><author><name sortKey="Hassan, A" uniqKey="Hassan A">A. Hassan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Abdulla, M H" uniqKey="Abdulla M">M.H. Abdulla</name></author><author><name sortKey="Ruelas, D S" uniqKey="Ruelas D">D.S. Ruelas</name></author><author><name sortKey="Wolff, B" uniqKey="Wolff B">B. Wolff</name></author><author><name sortKey="Snedecor, J" uniqKey="Snedecor J">J. Snedecor</name></author><author><name sortKey="Lim, K C" uniqKey="Lim K">K.C. Lim</name></author><author><name sortKey="Xu, F" uniqKey="Xu F">F. Xu</name></author><author><name sortKey="Renslo, A R" uniqKey="Renslo A">A.R. Renslo</name></author><author><name sortKey="Williams, J" uniqKey="Williams J">J. Williams</name></author><author><name sortKey="Mckerrow, J H" uniqKey="Mckerrow J">J.H. McKerrow</name></author><author><name sortKey="Caffrey, C R" uniqKey="Caffrey C">C.R. Caffrey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Abo Madyan, A A" uniqKey="Abo Madyan A">A.A. Abo-Madyan</name></author><author><name sortKey="Morsy, T A" uniqKey="Morsy T">T.A. Morsy</name></author><author><name sortKey="Motawea, S M" uniqKey="Motawea S">S.M. Motawea</name></author><author><name sortKey="Morsy, A T" uniqKey="Morsy A">A.T. Morsy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Adas, G" uniqKey="Adas G">G. Adas</name></author><author><name sortKey="Arikan, S" uniqKey="Arikan S">S. Arikan</name></author><author><name sortKey="Kemik, O" uniqKey="Kemik O">O. Kemik</name></author><author><name sortKey="Oner, A" uniqKey="Oner A">A. Oner</name></author><author><name sortKey="Sahip, N" uniqKey="Sahip N">N. Sahip</name></author><author><name sortKey="Karatepe, O" uniqKey="Karatepe O">O. Karatepe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Adenusi, A A" uniqKey="Adenusi A">A.A. Adenusi</name></author><author><name sortKey="Oke, A O" uniqKey="Oke A">A.O. Oke</name></author><author><name sortKey="Adenusi, A O" uniqKey="Adenusi A">A.O. Adenusi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Akaza, H" uniqKey="Akaza H">H. Akaza</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ali, R" uniqKey="Ali R">R. Ali</name></author><author><name sortKey="Ozkalemkas, F" uniqKey="Ozkalemkas F">F. Ozkalemkas</name></author><author><name sortKey="Ozkocaman, V" uniqKey="Ozkocaman V">V. Ozkocaman</name></author><author><name sortKey="Ozcelik, T" uniqKey="Ozcelik T">T. Ozcelik</name></author><author><name sortKey="Akalin, H" uniqKey="Akalin H">H. Akalin</name></author><author><name sortKey="Ozkan, A" uniqKey="Ozkan A">A. Ozkan</name></author><author><name sortKey="Altundal, Y" uniqKey="Altundal Y">Y. Altundal</name></author><author><name sortKey="Tunali, A" uniqKey="Tunali A">A. Tunali</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Allarakhia, M" uniqKey="Allarakhia M">M. Allarakhia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Altreuther, G" uniqKey="Altreuther G">G. Altreuther</name></author><author><name sortKey="Radeloff, I" uniqKey="Radeloff I">I. Radeloff</name></author><author><name sortKey="Lesueur, C" uniqKey="Lesueur C">C. LeSueur</name></author><author><name sortKey="Schimmel, A" uniqKey="Schimmel A">A. Schimmel</name></author><author><name sortKey="Krieger, K J" uniqKey="Krieger K">K.J. Krieger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Andrews, K T" uniqKey="Andrews K">K.T. Andrews</name></author><author><name sortKey="Fisher, G" uniqKey="Fisher G">G. Fisher</name></author><author><name sortKey="Skinner Adams, T S" uniqKey="Skinner Adams T">T.S. Skinner-Adams</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Andrews, P" uniqKey="Andrews P">P. Andrews</name></author><author><name sortKey="Thomas, H" uniqKey="Thomas H">H. Thomas</name></author><author><name sortKey="Pohlke, R" uniqKey="Pohlke R">R. Pohlke</name></author><author><name sortKey="Seubert, J" uniqKey="Seubert J">J. Seubert</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Anonymous" uniqKey="Anonymous">Anonymous</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Anonymous" uniqKey="Anonymous">Anonymous</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Anonymous" uniqKey="Anonymous">Anonymous</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Armson, A" uniqKey="Armson A">A. Armson</name></author><author><name sortKey="Cunningham, G A" uniqKey="Cunningham G">G.A. Cunningham</name></author><author><name sortKey="Grubb, W B" uniqKey="Grubb W">W.B. Grubb</name></author><author><name sortKey="Mendis, A H" uniqKey="Mendis A">A.H. Mendis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Awadzi, K" uniqKey="Awadzi K">K. Awadzi</name></author><author><name sortKey="Schulz Key, H" uniqKey="Schulz Key H">H. Schulz-Key</name></author><author><name sortKey="Howells, R E" uniqKey="Howells R">R.E. Howells</name></author><author><name sortKey="Haddock, D R" uniqKey="Haddock D">D.R. Haddock</name></author><author><name sortKey="Gilles, H M" uniqKey="Gilles H">H.M. Gilles</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Awadzi, K" uniqKey="Awadzi K">K. Awadzi</name></author><author><name sortKey="Edwards, G" uniqKey="Edwards G">G. Edwards</name></author><author><name sortKey="Opoku, N O" uniqKey="Opoku N">N.O. Opoku</name></author><author><name sortKey="Ardrey, A E" uniqKey="Ardrey A">A.E. Ardrey</name></author><author><name sortKey="Favager, S" uniqKey="Favager S">S. Favager</name></author><author><name sortKey="Addy, E T" uniqKey="Addy E">E.T. Addy</name></author><author><name sortKey="Attah, S K" uniqKey="Attah S">S.K. Attah</name></author><author><name sortKey="Yamuah, L K" uniqKey="Yamuah L">L.K. Yamuah</name></author><author><name sortKey="Quartey, B T" uniqKey="Quartey B">B.T. Quartey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Awadzi, K" uniqKey="Awadzi K">K. Awadzi</name></author><author><name sortKey="Opoku, N O" uniqKey="Opoku N">N.O. Opoku</name></author><author><name sortKey="Attah, S K" uniqKey="Attah S">S.K. Attah</name></author><author><name sortKey="Lazdins Helds, J" uniqKey="Lazdins Helds J">J. Lazdins-Helds</name></author><author><name sortKey="Kuesel, A C" uniqKey="Kuesel A">A.C. Kuesel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Awasthi, A" uniqKey="Awasthi A">A. Awasthi</name></author><author><name sortKey="Razzak, M" uniqKey="Razzak M">M. Razzak</name></author><author><name sortKey="Al Kassas, R" uniqKey="Al Kassas R">R. Al-Kassas</name></author><author><name sortKey="Harvey, J" uniqKey="Harvey J">J. Harvey</name></author><author><name sortKey="Garg, S" uniqKey="Garg S">S. Garg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Babalola, O E" uniqKey="Babalola O">O.E. Babalola</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Basra, A" uniqKey="Basra A">A. Basra</name></author><author><name sortKey="Mombo Ngoma, G" uniqKey="Mombo Ngoma G">G. Mombo-Ngoma</name></author><author><name sortKey="Melser, M C" uniqKey="Melser M">M.C. Melser</name></author><author><name sortKey="Diop, D A" uniqKey="Diop D">D.A. Diop</name></author><author><name sortKey="Wurbel, H" uniqKey="Wurbel H">H. Wurbel</name></author><author><name sortKey="Mackanga, J R" uniqKey="Mackanga J">J.R. Mackanga</name></author><author><name sortKey="Furstenau, M" uniqKey="Furstenau M">M. Furstenau</name></author><author><name sortKey="Zoleko, R M" uniqKey="Zoleko R">R.M. Zoleko</name></author><author><name sortKey="Adegnika, A A" uniqKey="Adegnika A">A.A. Adegnika</name></author><author><name sortKey="Gonzalez, R" uniqKey="Gonzalez R">R. Gonzalez</name></author><author><name sortKey="Menendez, C" uniqKey="Menendez C">C. Menendez</name></author><author><name sortKey="Kremsner, P G" uniqKey="Kremsner P">P.G. Kremsner</name></author><author><name sortKey="Ramharter, M" uniqKey="Ramharter M">M. Ramharter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bauer, C" uniqKey="Bauer C">C. Bauer</name></author><author><name sortKey="Conraths, F J" uniqKey="Conraths F">F.J. Conraths</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Beckman, S" uniqKey="Beckman S">S. Beckman</name></author><author><name sortKey="Grevelding, C G" uniqKey="Grevelding C">C.G. Grevelding</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bisoffi, Z" uniqKey="Bisoffi Z">Z. Bisoffi</name></author><author><name sortKey="Buonfrate, D" uniqKey="Buonfrate D">D. Buonfrate</name></author><author><name sortKey="Angheben, A" uniqKey="Angheben A">A. Angheben</name></author><author><name sortKey="Boscolo, M" uniqKey="Boscolo M">M. Boscolo</name></author><author><name sortKey="Anselmi, M" uniqKey="Anselmi M">M. Anselmi</name></author><author><name sortKey="Marocco, S" uniqKey="Marocco S">S. Marocco</name></author><author><name sortKey="Monteiro, G" uniqKey="Monteiro G">G. Monteiro</name></author><author><name sortKey="Gobbo, M" uniqKey="Gobbo M">M. Gobbo</name></author><author><name sortKey="Bisoffi, G" uniqKey="Bisoffi G">G. Bisoffi</name></author><author><name sortKey="Gobbi, F" uniqKey="Gobbi F">F. Gobbi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bisoffi, Z" uniqKey="Bisoffi Z">Z. Bisoffi</name></author><author><name sortKey="Buonfrate, D" uniqKey="Buonfrate D">D. Buonfrate</name></author><author><name sortKey="Montresor, A" uniqKey="Montresor A">A. Montresor</name></author><author><name sortKey="Requena Mendez, A" uniqKey="Requena Mendez A">A. Requena-Mendez</name></author><author><name sortKey="Munoz, J" uniqKey="Munoz J">J. Munoz</name></author><author><name sortKey="Krolewiecki, A J" uniqKey="Krolewiecki A">A.J. Krolewiecki</name></author><author><name sortKey="Gotuzzo, E" uniqKey="Gotuzzo E">E. Gotuzzo</name></author><author><name sortKey="Mena, M A" uniqKey="Mena M">M.A. Mena</name></author><author><name sortKey="Chiodini, P L" uniqKey="Chiodini P">P.L. Chiodini</name></author><author><name sortKey="Anselmi, M" uniqKey="Anselmi M">M. Anselmi</name></author><author><name sortKey="Moreira, J" uniqKey="Moreira J">J. Moreira</name></author><author><name sortKey="Albonico, M" uniqKey="Albonico M">M. Albonico</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Blagburn, B L" uniqKey="Blagburn B">B.L. Blagburn</name></author><author><name sortKey="Hendrix, C M" uniqKey="Hendrix C">C.M. Hendrix</name></author><author><name sortKey="Lindsay, D S" uniqKey="Lindsay D">D.S. Lindsay</name></author><author><name sortKey="Vaughan, J L" uniqKey="Vaughan J">J.L. Vaughan</name></author><author><name sortKey="Hepler, D I" uniqKey="Hepler D">D.I. Hepler</name></author><author><name sortKey="Wright, J C" uniqKey="Wright J">J.C. Wright</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Botros, S S" uniqKey="Botros S">S.S. Botros</name></author><author><name sortKey="El Lakkany, N M" uniqKey="El Lakkany N">N.M. El-Lakkany</name></author><author><name sortKey="Badawy, A A" uniqKey="Badawy A">A.A. Badawy</name></author><author><name sortKey="Mahmoud, S S" uniqKey="Mahmoud S">S.S. Mahmoud</name></author><author><name sortKey="Ebeid, F A" uniqKey="Ebeid F">F.A. Ebeid</name></author><author><name sortKey="Fenwick, A" uniqKey="Fenwick A">A. Fenwick</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brennan, G P" uniqKey="Brennan G">G.P. Brennan</name></author><author><name sortKey="Fairweather, I" uniqKey="Fairweather I">I. Fairweather</name></author><author><name sortKey="Trudgett, A" uniqKey="Trudgett A">A. Trudgett</name></author><author><name sortKey="Hoey, E" uniqKey="Hoey E">E. Hoey</name></author><author><name sortKey="Mccoy" uniqKey="Mccoy">McCoy</name></author><author><name sortKey="Mcconville, M" uniqKey="Mcconville M">M. McConville</name></author><author><name sortKey="Meaney, M" uniqKey="Meaney M">M. Meaney</name></author><author><name sortKey="Robinson, M" uniqKey="Robinson M">M. Robinson</name></author><author><name sortKey="Mcferran, N" uniqKey="Mcferran N">N. McFerran</name></author><author><name sortKey="Ryan, L" uniqKey="Ryan L">L. Ryan</name></author><author><name sortKey="Lanusse, C" uniqKey="Lanusse C">C. Lanusse</name></author><author><name sortKey="Mottier, L" uniqKey="Mottier L">L. Mottier</name></author><author><name sortKey="Alvarez, L" uniqKey="Alvarez L">L. Alvarez</name></author><author><name sortKey="Solana, H" uniqKey="Solana H">H. Solana</name></author><author><name sortKey="Virkel, G" uniqKey="Virkel G">G. Virkel</name></author><author><name sortKey="Brophy, P M" uniqKey="Brophy P">P.M. Brophy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bruch, K" uniqKey="Bruch K">K. Bruch</name></author><author><name sortKey="Haas, J" uniqKey="Haas J">J. Haas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brunetti, E" uniqKey="Brunetti E">E. Brunetti</name></author><author><name sortKey="Kern, P" uniqKey="Kern P">P. Kern</name></author><author><name sortKey="Vuitton, D A" uniqKey="Vuitton D">D.A. Vuitton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brunetti, E" uniqKey="Brunetti E">E. Brunetti</name></author><author><name sortKey="White, A C" uniqKey="White A">A.C. White</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bueding, E" uniqKey="Bueding E">E. Bueding</name></author><author><name sortKey="Hawkins, J" uniqKey="Hawkins J">J. Hawkins</name></author><author><name sortKey="Cha, Y N" uniqKey="Cha Y">Y.N. Cha</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bunnag, D" uniqKey="Bunnag D">D. Bunnag</name></author><author><name sortKey="Harinasuta, T" uniqKey="Harinasuta T">T. Harinasuta</name></author><author><name sortKey="Viravan, C" uniqKey="Viravan C">C. Viravan</name></author><author><name sortKey="Jarupakorn, V" uniqKey="Jarupakorn V">V. Jarupakorn</name></author><author><name sortKey="Chindanond, D" uniqKey="Chindanond D">D. Chindanond</name></author><author><name sortKey="Desakorn, V" uniqKey="Desakorn V">V. Desakorn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bygott, J M" uniqKey="Bygott J">J.M. Bygott</name></author><author><name sortKey="Chiodini, P L" uniqKey="Chiodini P">P.L. Chiodini</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Caffrey, C R" uniqKey="Caffrey C">C.R. Caffrey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Carpio, A" uniqKey="Carpio A">A. Carpio</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Catton, D G" uniqKey="Catton D">D.G. Catton</name></author><author><name sortKey="Van Schalkwyk, P C" uniqKey="Van Schalkwyk P">P.C. Van Schalkwyk</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ceballos, L" uniqKey="Ceballos L">L. Ceballos</name></author><author><name sortKey="Elissondo, M" uniqKey="Elissondo M">M. Elissondo</name></author><author><name sortKey="Bruni, S S" uniqKey="Bruni S">S.S. Bruni</name></author><author><name sortKey="Denegri, G" uniqKey="Denegri G">G. Denegri</name></author><author><name sortKey="Alvarez, L" uniqKey="Alvarez L">L. Alvarez</name></author><author><name sortKey="Lanusse, C" uniqKey="Lanusse C">C. Lanusse</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ceballos, L" uniqKey="Ceballos L">L. Ceballos</name></author><author><name sortKey="Elissondo, C" uniqKey="Elissondo C">C. Elissondo</name></author><author><name sortKey="Sanchez Bruni, S" uniqKey="Sanchez Bruni S">S. Sanchez Bruni</name></author><author><name sortKey="Denegri, G" uniqKey="Denegri G">G. Denegri</name></author><author><name sortKey="Lanusse, C" uniqKey="Lanusse C">C. Lanusse</name></author><author><name sortKey="Alvarez, L" uniqKey="Alvarez L">L. Alvarez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ceballos, L" uniqKey="Ceballos L">L. Ceballos</name></author><author><name sortKey="Moreno, L" uniqKey="Moreno L">L. Moreno</name></author><author><name sortKey="Torrado, J J" uniqKey="Torrado J">J.J. Torrado</name></author><author><name sortKey="Lanusse, C" uniqKey="Lanusse C">C. Lanusse</name></author><author><name sortKey="Alvarez, L" uniqKey="Alvarez L">L. Alvarez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cobo, F" uniqKey="Cobo F">F. Cobo</name></author><author><name sortKey="Yarnoz, C" uniqKey="Yarnoz C">C. Yarnoz</name></author><author><name sortKey="Sesma, B" uniqKey="Sesma B">B. Sesma</name></author><author><name sortKey="Fraile, P" uniqKey="Fraile P">P. Fraile</name></author><author><name sortKey="Aizcorbe, M" uniqKey="Aizcorbe M">M. Aizcorbe</name></author><author><name sortKey="Trujillo, R" uniqKey="Trujillo R">R. Trujillo</name></author><author><name sortKey="Diaz De Liano, A" uniqKey="Diaz De Liano A">A. Diaz-de-Liano</name></author><author><name sortKey="Ciga, M A" uniqKey="Ciga M">M.A. Ciga</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cohen, D J" uniqKey="Cohen D">D.J. Cohen</name></author><author><name sortKey="Loertscher, R" uniqKey="Loertscher R">R. Loertscher</name></author><author><name sortKey="Rubin, M F" uniqKey="Rubin M">M.F. Rubin</name></author><author><name sortKey="Tilney, N L" uniqKey="Tilney N">N.L. Tilney</name></author><author><name sortKey="Carpenter, C B" uniqKey="Carpenter C">C.B. Carpenter</name></author><author><name sortKey="Strom, T B" uniqKey="Strom T">T.B. Strom</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Coles, G C" uniqKey="Coles G">G.C. Coles</name></author><author><name sortKey="Giordano Fenton, D J" uniqKey="Giordano Fenton D">D.J. Giordano-Fenton</name></author><author><name sortKey="Tritschler, J P" uniqKey="Tritschler J">J.P. Tritschler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cotreau, M M" uniqKey="Cotreau M">M.M. Cotreau</name></author><author><name sortKey="Warren, S" uniqKey="Warren S">S. Warren</name></author><author><name sortKey="Ryan, J L" uniqKey="Ryan J">J.L. Ryan</name></author><author><name sortKey="Fleckenstein, L" uniqKey="Fleckenstein L">L. Fleckenstein</name></author><author><name sortKey="Vanapalli, S R" uniqKey="Vanapalli S">S.R. Vanapalli</name></author><author><name sortKey="Brown, K R" uniqKey="Brown K">K.R. Brown</name></author><author><name sortKey="Rock, D" uniqKey="Rock D">D. Rock</name></author><author><name sortKey="Chen, C Y" uniqKey="Chen C">C.Y. Chen</name></author><author><name sortKey="Schwertschlag, U S" uniqKey="Schwertschlag U">U.S. Schwertschlag</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Coulibaly, Y I" uniqKey="Coulibaly Y">Y.I. Coulibaly</name></author><author><name sortKey="Dembele, B" uniqKey="Dembele B">B. Dembele</name></author><author><name sortKey="Diallo, A A" uniqKey="Diallo A">A.A. Diallo</name></author><author><name sortKey="Lipner, E M" uniqKey="Lipner E">E.M. Lipner</name></author><author><name sortKey="Doumbia, S S" uniqKey="Doumbia S">S.S. Doumbia</name></author><author><name sortKey="Coulibaly, S Y" uniqKey="Coulibaly S">S.Y. Coulibaly</name></author><author><name sortKey="Konate, S" uniqKey="Konate S">S. Konate</name></author><author><name sortKey="Diallo, D A" uniqKey="Diallo D">D.A. Diallo</name></author><author><name sortKey="Yalcouye, D" uniqKey="Yalcouye D">D. Yalcouye</name></author><author><name sortKey="Kubofcik, J" uniqKey="Kubofcik J">J. Kubofcik</name></author><author><name sortKey="Doumbo, O K" uniqKey="Doumbo O">O.K. Doumbo</name></author><author><name sortKey="Traore, A K" uniqKey="Traore A">A.K. Traore</name></author><author><name sortKey="Keita, A D" uniqKey="Keita A">A.D. Keita</name></author><author><name sortKey="Fay, M P" uniqKey="Fay M">M.P. Fay</name></author><author><name sortKey="Traore, S F" uniqKey="Traore S">S.F. Traore</name></author><author><name sortKey="Nutman, T B" uniqKey="Nutman T">T.B. Nutman</name></author><author><name sortKey="Klion, A D" uniqKey="Klion A">A.D. Klion</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Davidson, R N" uniqKey="Davidson R">R.N. Davidson</name></author><author><name sortKey="Den Boer, M" uniqKey="Den Boer M">M. den Boer</name></author><author><name sortKey="Ritmeijer, K" uniqKey="Ritmeijer K">K. Ritmeijer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Silva, D G" uniqKey="De Silva D">D.G. de Silva</name></author><author><name sortKey="Lionel, N D" uniqKey="Lionel N">N.D. Lionel</name></author><author><name sortKey="Jayatilleka, S M" uniqKey="Jayatilleka S">S.M. Jayatilleka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Debrah, A Y" uniqKey="Debrah A">A.Y. Debrah</name></author><author><name sortKey="Mand, S" uniqKey="Mand S">S. Mand</name></author><author><name sortKey="Marfo Debrekyei, Y" uniqKey="Marfo Debrekyei Y">Y. Marfo-Debrekyei</name></author><author><name sortKey="Batsa, L" uniqKey="Batsa L">L. Batsa</name></author><author><name sortKey="Pfarr, K" uniqKey="Pfarr K">K. Pfarr</name></author><author><name sortKey="Buttner, M" uniqKey="Buttner M">M. Buttner</name></author><author><name sortKey="Adjei, O" uniqKey="Adjei O">O. Adjei</name></author><author><name sortKey="Buttner, D" uniqKey="Buttner D">D. Buttner</name></author><author><name sortKey="Hoerauf, A" uniqKey="Hoerauf A">A. Hoerauf</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Debrah, A Y" uniqKey="Debrah A">A.Y. Debrah</name></author><author><name sortKey="Mand, S" uniqKey="Mand S">S. Mand</name></author><author><name sortKey="Marfo Debrekyei, Y" uniqKey="Marfo Debrekyei Y">Y. Marfo-Debrekyei</name></author><author><name sortKey="Batsa, L" uniqKey="Batsa L">L. Batsa</name></author><author><name sortKey="Pfarr, K" uniqKey="Pfarr K">K. Pfarr</name></author><author><name sortKey="Lawson, B" uniqKey="Lawson B">B. Lawson</name></author><author><name sortKey="Taylor, M" uniqKey="Taylor M">M. Taylor</name></author><author><name sortKey="Adjei, O" uniqKey="Adjei O">O. Adjei</name></author><author><name sortKey="Hoerauf, A" uniqKey="Hoerauf A">A. Hoerauf</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Deger, E" uniqKey="Deger E">E. Deger</name></author><author><name sortKey="Hokelek, M" uniqKey="Hokelek M">M. Hokelek</name></author><author><name sortKey="Deger, B A" uniqKey="Deger B">B.A. Deger</name></author><author><name sortKey="Tutar, E" uniqKey="Tutar E">E. Tutar</name></author><author><name sortKey="Asil, M" uniqKey="Asil M">M. Asil</name></author><author><name sortKey="Pakdemirli, E" uniqKey="Pakdemirli E">E. Pakdemirli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Den Hollander, P" uniqKey="Den Hollander P">P. den Hollander</name></author><author><name sortKey="Savage, M I" uniqKey="Savage M">M.I. Savage</name></author><author><name sortKey="Brown, P H" uniqKey="Brown P">P.H. Brown</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Diaz, E" uniqKey="Diaz E">E. Diaz</name></author><author><name sortKey="Mondragon, J" uniqKey="Mondragon J">J. Mondragon</name></author><author><name sortKey="Ramirez, E" uniqKey="Ramirez E">E. Ramirez</name></author><author><name sortKey="Bernal, R" uniqKey="Bernal R">R. Bernal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dissous, C" uniqKey="Dissous C">C. Dissous</name></author><author><name sortKey="Grevelding, C G" uniqKey="Grevelding C">C.G. Grevelding</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dominguez Vazquez, A" uniqKey="Dominguez Vazquez A">A. Dominguez-Vazquez</name></author><author><name sortKey="Taylor, H R" uniqKey="Taylor H">H.R. Taylor</name></author><author><name sortKey="Greene, B M" uniqKey="Greene B">B.M. Greene</name></author><author><name sortKey="Ruvalcaba Macias, A M" uniqKey="Ruvalcaba Macias A">A.M. Ruvalcaba-Macias</name></author><author><name sortKey="Rivas Alcala, A R" uniqKey="Rivas Alcala A">A.R. Rivas-Alcala</name></author><author><name sortKey="Murphy, R P" uniqKey="Murphy R">R.P. Murphy</name></author><author><name sortKey="Beltran Hernandez, F" uniqKey="Beltran Hernandez F">F. Beltran-Hernandez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dorlo, T P" uniqKey="Dorlo T">T.P. Dorlo</name></author><author><name sortKey="Balasegaram, M" uniqKey="Balasegaram M">M. Balasegaram</name></author><author><name sortKey="Beijnen, J H" uniqKey="Beijnen J">J.H. Beijnen</name></author><author><name sortKey="De Vries, P J" uniqKey="De Vries P">P.J. de Vries</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dreyer, G" uniqKey="Dreyer G">G. Dreyer</name></author><author><name sortKey="Addiss, D" uniqKey="Addiss D">D. Addiss</name></author><author><name sortKey="Williamson, J" uniqKey="Williamson J">J. Williamson</name></author><author><name sortKey="Noroes, J" uniqKey="Noroes J">J. Noroes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Eissa, M M" uniqKey="Eissa M">M.M. Eissa</name></author><author><name sortKey="El Azzouni, M Z" uniqKey="El Azzouni M">M.Z. El-Azzouni</name></author><author><name sortKey="Amer, E I" uniqKey="Amer E">E.I. Amer</name></author><author><name sortKey="Baddour, N M" uniqKey="Baddour N">N.M. Baddour</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Eissa, M M" uniqKey="Eissa M">M.M. Eissa</name></author><author><name sortKey="El Bardicy, S" uniqKey="El Bardicy S">S. El Bardicy</name></author><author><name sortKey="Tadros, M" uniqKey="Tadros M">M. Tadros</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="El Bialy, S A" uniqKey="El Bialy S">S.A. El Bialy</name></author><author><name sortKey="Taman, A" uniqKey="Taman A">A. Taman</name></author><author><name sortKey="El Beshbishi, S N" uniqKey="El Beshbishi S">S.N. El-Beshbishi</name></author><author><name sortKey="Mansour, B" uniqKey="Mansour B">B. Mansour</name></author><author><name sortKey="El Malky, M" uniqKey="El Malky M">M. El-Malky</name></author><author><name sortKey="Bayoumi, W A" uniqKey="Bayoumi W">W.A. Bayoumi</name></author><author><name sortKey="Essa, H M" uniqKey="Essa H">H.M. Essa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Erzurumlu, K" uniqKey="Erzurumlu K">K. Erzurumlu</name></author><author><name sortKey="Hokelek, M" uniqKey="Hokelek M">M. Hokelek</name></author><author><name sortKey="Baris, S" uniqKey="Baris S">S. Baris</name></author><author><name sortKey="Sahin, M" uniqKey="Sahin M">M. Sahin</name></author><author><name sortKey="Birinci, A" uniqKey="Birinci A">A. Birinci</name></author><author><name sortKey="Amanvermez, R" uniqKey="Amanvermez R">R. Amanvermez</name></author><author><name sortKey="Tac, K" uniqKey="Tac K">K. Tac</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Escobedo, G" uniqKey="Escobedo G">G. Escobedo</name></author><author><name sortKey="Palacios Arreola, M I" uniqKey="Palacios Arreola M">M.I. Palacios-Arreola</name></author><author><name sortKey="Olivos, A" uniqKey="Olivos A">A. Olivos</name></author><author><name sortKey="Lopez Griego, L" uniqKey="Lopez Griego L">L. Lopez-Griego</name></author><author><name sortKey="Morales Montor, J" uniqKey="Morales Montor J">J. Morales-Montor</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Favennec, L" uniqKey="Favennec L">L. Favennec</name></author><author><name sortKey="Jave Ortiz, J" uniqKey="Jave Ortiz J">J. Jave Ortiz</name></author><author><name sortKey="Gargala, G" uniqKey="Gargala G">G. Gargala</name></author><author><name sortKey="Lopez Chegne, N" uniqKey="Lopez Chegne N">N. Lopez Chegne</name></author><author><name sortKey="Ayoub, A" uniqKey="Ayoub A">A. Ayoub</name></author><author><name sortKey="Rossignol, J F" uniqKey="Rossignol J">J.F. Rossignol</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Franz, M" uniqKey="Franz M">M. Franz</name></author><author><name sortKey="Zahner, H" uniqKey="Zahner H">H. Zahner</name></author><author><name sortKey="Benten, P" uniqKey="Benten P">P. Benten</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Furst, T" uniqKey="Furst T">T. Fürst</name></author><author><name sortKey="Duthaler, U" uniqKey="Duthaler U">U. Duthaler</name></author><author><name sortKey="Sripa, B" uniqKey="Sripa B">B. Sripa</name></author><author><name sortKey="Utzinger, J" uniqKey="Utzinger J">J. Utzinger</name></author><author><name sortKey="Keiser, J" uniqKey="Keiser J">J. Keiser</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gann, P H" uniqKey="Gann P">P.H. Gann</name></author><author><name sortKey="Neva, F A" uniqKey="Neva F">F.A. Neva</name></author><author><name sortKey="Gam, A A" uniqKey="Gam A">A.A. Gam</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Garcia, E G" uniqKey="Garcia E">E.G. Garcia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Garcia, H H" uniqKey="Garcia H">H.H. Garcia</name></author><author><name sortKey="Lescano, A G" uniqKey="Lescano A">A.G. Lescano</name></author><author><name sortKey="Lanchote, V L" uniqKey="Lanchote V">V.L. Lanchote</name></author><author><name sortKey="Pretell, E J" uniqKey="Pretell E">E.J. Pretell</name></author><author><name sortKey="Gonzales, I" uniqKey="Gonzales I">I. Gonzales</name></author><author><name sortKey="Bustos, J A" uniqKey="Bustos J">J.A. Bustos</name></author><author><name sortKey="Takayanagui, O M" uniqKey="Takayanagui O">O.M. Takayanagui</name></author><author><name sortKey="Bonato, P S" uniqKey="Bonato P">P.S. Bonato</name></author><author><name sortKey="Horton, J" uniqKey="Horton J">J. Horton</name></author><author><name sortKey="Saavedra, H" uniqKey="Saavedra H">H. Saavedra</name></author><author><name sortKey="Gonzalez, A E" uniqKey="Gonzalez A">A.E. Gonzalez</name></author><author><name sortKey="Gilman, R H" uniqKey="Gilman R">R.H. Gilman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gardner, J M" uniqKey="Gardner J">J.M. Gardner</name></author><author><name sortKey="Grantham Mcgregor, S" uniqKey="Grantham Mcgregor S">S. Grantham-McGregor</name></author><author><name sortKey="Baddeley, A" uniqKey="Baddeley A">A. Baddeley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gavidia, C M" uniqKey="Gavidia C">C.M. Gavidia</name></author><author><name sortKey="Gonzalez, A E" uniqKey="Gonzalez A">A.E. Gonzalez</name></author><author><name sortKey="Barron, E A" uniqKey="Barron E">E.A. Barron</name></author><author><name sortKey="Ninaquispe, B" uniqKey="Ninaquispe B">B. Ninaquispe</name></author><author><name sortKey="Llamosas, M" uniqKey="Llamosas M">M. Llamosas</name></author><author><name sortKey="Verastegui, M R" uniqKey="Verastegui M">M.R. Verastegui</name></author><author><name sortKey="Robinson, C" uniqKey="Robinson C">C. Robinson</name></author><author><name sortKey="Gilman, R H" uniqKey="Gilman R">R.H. Gilman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gayen, P" uniqKey="Gayen P">P. Gayen</name></author><author><name sortKey="Nayak, A" uniqKey="Nayak A">A. Nayak</name></author><author><name sortKey="Saini, P" uniqKey="Saini P">P. Saini</name></author><author><name sortKey="Mukherjee, N" uniqKey="Mukherjee N">N. Mukherjee</name></author><author><name sortKey="Maitra, S" uniqKey="Maitra S">S. Maitra</name></author><author><name sortKey="Sarkar, P" uniqKey="Sarkar P">P. Sarkar</name></author><author><name sortKey="Sinha Babu, S P" uniqKey="Sinha Babu S">S.P. Sinha Babu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Geary, T G" uniqKey="Geary T">T.G. Geary</name></author><author><name sortKey="Mackenzie, C D" uniqKey="Mackenzie C">C.D. Mackenzie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Greaves, D" uniqKey="Greaves D">D. Greaves</name></author><author><name sortKey="Coggle, S" uniqKey="Coggle S">S. Coggle</name></author><author><name sortKey="Pollard, C" uniqKey="Pollard C">C. Pollard</name></author><author><name sortKey="Aliyu, S H" uniqKey="Aliyu S">S.H. Aliyu</name></author><author><name sortKey="Moore, E M" uniqKey="Moore E">E.M. Moore</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gryseels, B" uniqKey="Gryseels B">B. Gryseels</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Harder, A" uniqKey="Harder A">A. Harder</name></author><author><name sortKey="Von Samson Himmelstjerna, G" uniqKey="Von Samson Himmelstjerna G">G. von Samson-Himmelstjerna</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Harder, A" uniqKey="Harder A">A. Harder</name></author><author><name sortKey="Schmitt Wrede, H P" uniqKey="Schmitt Wrede H">H.P. Schmitt-Wrede</name></author><author><name sortKey="Krucken, J" uniqKey="Krucken J">J. Krucken</name></author><author><name sortKey="Marinovski, P" uniqKey="Marinovski P">P. Marinovski</name></author><author><name sortKey="Wunderlich, F" uniqKey="Wunderlich F">F. Wunderlich</name></author><author><name sortKey="Willson, J" uniqKey="Willson J">J. Willson</name></author><author><name sortKey="Amliwala, K" uniqKey="Amliwala K">K. Amliwala</name></author><author><name sortKey="Holden Dye, L" uniqKey="Holden Dye L">L. Holden-Dye</name></author><author><name sortKey="Walker, R" uniqKey="Walker R">R. Walker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hemphill, A" uniqKey="Hemphill A">A. Hemphill</name></author><author><name sortKey="Mueller, J" uniqKey="Mueller J">J. Mueller</name></author><author><name sortKey="Esposito, M" uniqKey="Esposito M">M. Esposito</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hien, T T" uniqKey="Hien T">T.T. Hien</name></author><author><name sortKey="Truong, N T" uniqKey="Truong N">N.T. Truong</name></author><author><name sortKey="Minh, N H" uniqKey="Minh N">N.H. Minh</name></author><author><name sortKey="Dat, H D" uniqKey="Dat H">H.D. Dat</name></author><author><name sortKey="Dung, N T" uniqKey="Dung N">N.T. Dung</name></author><author><name sortKey="Hue, N T" uniqKey="Hue N">N.T. Hue</name></author><author><name sortKey="Dung, T K" uniqKey="Dung T">T.K. Dung</name></author><author><name sortKey="Tuan, P Q" uniqKey="Tuan P">P.Q. Tuan</name></author><author><name sortKey="Campbell, J I" uniqKey="Campbell J">J.I. Campbell</name></author><author><name sortKey="Farrar, J J" uniqKey="Farrar J">J.J. Farrar</name></author><author><name sortKey="Day, J N" uniqKey="Day J">J.N. Day</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ho, W E" uniqKey="Ho W">W.E. Ho</name></author><author><name sortKey="Peh, H Y" uniqKey="Peh H">H.Y. Peh</name></author><author><name sortKey="Chan, T K" uniqKey="Chan T">T.K. Chan</name></author><author><name sortKey="Wong, W S" uniqKey="Wong W">W.S. Wong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hoerauf, A" uniqKey="Hoerauf A">A. Hoerauf</name></author><author><name sortKey="Mand, S" uniqKey="Mand S">S. Mand</name></author><author><name sortKey="Volkmann, L" uniqKey="Volkmann L">L. Volkmann</name></author><author><name sortKey="Buttner, M" uniqKey="Buttner M">M. Buttner</name></author><author><name sortKey="Marfo Debrekyei, Y" uniqKey="Marfo Debrekyei Y">Y. Marfo-Debrekyei</name></author><author><name sortKey="Taylor, M" uniqKey="Taylor M">M. Taylor</name></author><author><name sortKey="Adjei, O" uniqKey="Adjei O">O. Adjei</name></author><author><name sortKey="Buttner, D W" uniqKey="Buttner D">D.W. Buttner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hoerauf, A" uniqKey="Hoerauf A">A. Hoerauf</name></author><author><name sortKey="Marfo Debrekyei, Y" uniqKey="Marfo Debrekyei Y">Y. Marfo-Debrekyei</name></author><author><name sortKey="Buttner, M" uniqKey="Buttner M">M. Buttner</name></author><author><name sortKey="Debrah, A Y" uniqKey="Debrah A">A.Y. Debrah</name></author><author><name sortKey="Konadu, P" uniqKey="Konadu P">P. Konadu</name></author><author><name sortKey="Mand, S" uniqKey="Mand S">S. Mand</name></author><author><name sortKey="Adjei, O" uniqKey="Adjei O">O. Adjei</name></author><author><name sortKey="Buttner, D W" uniqKey="Buttner D">D.W. Buttner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hoerauf, A" uniqKey="Hoerauf A">A. Hoerauf</name></author><author><name sortKey="Specht, S" uniqKey="Specht S">S. Specht</name></author><author><name sortKey="Buttner, M" uniqKey="Buttner M">M. Buttner</name></author><author><name sortKey="Pfarr, K" uniqKey="Pfarr K">K. Pfarr</name></author><author><name sortKey="Mand, S" uniqKey="Mand S">S. Mand</name></author><author><name sortKey="Fimmers, R" uniqKey="Fimmers R">R. Fimmers</name></author><author><name sortKey="Marfo Debrekyei, Y" uniqKey="Marfo Debrekyei Y">Y. Marfo-Debrekyei</name></author><author><name sortKey="Konadu, P" uniqKey="Konadu P">P. Konadu</name></author><author><name sortKey="Debrah, A Y" uniqKey="Debrah A">A.Y. Debrah</name></author><author><name sortKey="Bandi, C" uniqKey="Bandi C">C. Bandi</name></author><author><name sortKey="Brattig, N" uniqKey="Brattig N">N. Brattig</name></author><author><name sortKey="Albers, A" uniqKey="Albers A">A. Albers</name></author><author><name sortKey="Larbi, J" uniqKey="Larbi J">J. Larbi</name></author><author><name sortKey="Batsa, L" uniqKey="Batsa L">L. Batsa</name></author><author><name sortKey="Taylor, M J" uniqKey="Taylor M">M.J. Taylor</name></author><author><name sortKey="Adjei, O" uniqKey="Adjei O">O. Adjei</name></author><author><name sortKey="Buttner, D W" uniqKey="Buttner D">D.W. Buttner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Holmstedt, B" uniqKey="Holmstedt B">B. Holmstedt</name></author><author><name sortKey="Nordgren, I" uniqKey="Nordgren I">I. Nordgren</name></author><author><name sortKey="Sandoz, M" uniqKey="Sandoz M">M. Sandoz</name></author><author><name sortKey="Sundwall, A" uniqKey="Sundwall A">A. Sundwall</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hotez, P J" uniqKey="Hotez P">P.J. Hotez</name></author><author><name sortKey="Molyneux, D H" uniqKey="Molyneux D">D.H. Molyneux</name></author><author><name sortKey="Fenwick, A" uniqKey="Fenwick A">A. Fenwick</name></author><author><name sortKey="Ottesen, E" uniqKey="Ottesen E">E. Ottesen</name></author><author><name sortKey="Ehrlich Sachs, S" uniqKey="Ehrlich Sachs S">S. Ehrlich Sachs</name></author><author><name sortKey="Sachs, J D" uniqKey="Sachs J">J.D. Sachs</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huang, Y X" uniqKey="Huang Y">Y.X. Huang</name></author><author><name sortKey="Zhou, J X" uniqKey="Zhou J">J.X. Zhou</name></author><author><name sortKey="Xue, Z Q" uniqKey="Xue Z">Z.Q. Xue</name></author><author><name sortKey="Wu, Y X" uniqKey="Wu Y">Y.X. Wu</name></author><author><name sortKey="Chen, J Y" uniqKey="Chen J">J.Y. Chen</name></author><author><name sortKey="Wu, H Z" uniqKey="Wu H">H.Z. Wu</name></author><author><name sortKey="Ji, M H" uniqKey="Ji M">M.H. Ji</name></author><author><name sortKey="Shen, Y P" uniqKey="Shen Y">Y.P. Shen</name></author><author><name sortKey="Cao, G Q" uniqKey="Cao G">G.Q. Cao</name></author><author><name sortKey="Wu, Z X" uniqKey="Wu Z">Z.X. Wu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Inaoka, T" uniqKey="Inaoka T">T. Inaoka</name></author><author><name sortKey="Nakao, M" uniqKey="Nakao M">M. Nakao</name></author><author><name sortKey="Ohnishi, K" uniqKey="Ohnishi K">K. Ohnishi</name></author><author><name sortKey="Kutsumi, H" uniqKey="Kutsumi H">H. Kutsumi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ingold, K" uniqKey="Ingold K">K. Ingold</name></author><author><name sortKey="Bigler, P" uniqKey="Bigler P">P. Bigler</name></author><author><name sortKey="Thormann, W" uniqKey="Thormann W">W. Thormann</name></author><author><name sortKey="Cavaliero, T" uniqKey="Cavaliero T">T. Cavaliero</name></author><author><name sortKey="Gottstein, B" uniqKey="Gottstein B">B. Gottstein</name></author><author><name sortKey="Hemphill, A" uniqKey="Hemphill A">A. Hemphill</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ingram, K" uniqKey="Ingram K">K. Ingram</name></author><author><name sortKey="Ellis, W" uniqKey="Ellis W">W. Ellis</name></author><author><name sortKey="Keiser, J" uniqKey="Keiser J">J. Keiser</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ingram, K" uniqKey="Ingram K">K. Ingram</name></author><author><name sortKey="Schiaffo, C E" uniqKey="Schiaffo C">C.E. Schiaffo</name></author><author><name sortKey="Sittiwong, W" uniqKey="Sittiwong W">W. Sittiwong</name></author><author><name sortKey="Benner, E" uniqKey="Benner E">E. Benner</name></author><author><name sortKey="Dussault, P H" uniqKey="Dussault P">P.H. Dussault</name></author><author><name sortKey="Keiser, J" uniqKey="Keiser J">J. Keiser</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ingram Sieber, K" uniqKey="Ingram Sieber K">K. Ingram-Sieber</name></author><author><name sortKey="Cowan, N" uniqKey="Cowan N">N. Cowan</name></author><author><name sortKey="Panic, G" uniqKey="Panic G">G. Panic</name></author><author><name sortKey="Vargas, M" uniqKey="Vargas M">M. Vargas</name></author><author><name sortKey="Mansour, N R" uniqKey="Mansour N">N.R. Mansour</name></author><author><name sortKey="Bickle, Q D" uniqKey="Bickle Q">Q.D. Bickle</name></author><author><name sortKey="Wells, T N" uniqKey="Wells T">T.N. Wells</name></author><author><name sortKey="Spangenberg, T" uniqKey="Spangenberg T">T. Spangenberg</name></author><author><name sortKey="Keiser, J" uniqKey="Keiser J">J. Keiser</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jones, R M" uniqKey="Jones R">R.M. Jones</name></author><author><name sortKey="Logan, N B" uniqKey="Logan N">N.B. Logan</name></author><author><name sortKey="Weatherley, A J" uniqKey="Weatherley A">A.J. Weatherley</name></author><author><name sortKey="Little, A S" uniqKey="Little A">A.S. Little</name></author><author><name sortKey="Smothers, C D" uniqKey="Smothers C">C.D. Smothers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Juan, J O" uniqKey="Juan J">J.O. Juan</name></author><author><name sortKey="Lopez Chegne, N" uniqKey="Lopez Chegne N">N. Lopez Chegne</name></author><author><name sortKey="Gargala, G" uniqKey="Gargala G">G. Gargala</name></author><author><name sortKey="Favennec, L" uniqKey="Favennec L">L. Favennec</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kamgno, J" uniqKey="Kamgno J">J. Kamgno</name></author><author><name sortKey="Pion, S D" uniqKey="Pion S">S.D. Pion</name></author><author><name sortKey="Tejiokem, M C" uniqKey="Tejiokem M">M.C. Tejiokem</name></author><author><name sortKey="Twum Danso, N A" uniqKey="Twum Danso N">N.A. Twum-Danso</name></author><author><name sortKey="Thylefors, B" uniqKey="Thylefors B">B. Thylefors</name></author><author><name sortKey="Boussinesq, M" uniqKey="Boussinesq M">M. Boussinesq</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kamgno, J" uniqKey="Kamgno J">J. Kamgno</name></author><author><name sortKey="Djomo, P N" uniqKey="Djomo P">P.N. Djomo</name></author><author><name sortKey="Pion, S D" uniqKey="Pion S">S.D. Pion</name></author><author><name sortKey="Thylefors, B" uniqKey="Thylefors B">B. Thylefors</name></author><author><name sortKey="Boussinesq, M" uniqKey="Boussinesq M">M. Boussinesq</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kan, S P" uniqKey="Kan S">S.P. Kan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Katiyar, D" uniqKey="Katiyar D">D. Katiyar</name></author><author><name sortKey="Singh, L K" uniqKey="Singh L">L.K. Singh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Katz, N" uniqKey="Katz N">N. Katz</name></author><author><name sortKey="Couto, F F" uniqKey="Couto F">F.F. Couto</name></author><author><name sortKey="Araujo, N" uniqKey="Araujo N">N. Araujo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Keiser, J" uniqKey="Keiser J">J. Keiser</name></author><author><name sortKey="Utzinger, J" uniqKey="Utzinger J">J. Utzinger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Keiser, J" uniqKey="Keiser J">J. Keiser</name></author><author><name sortKey="Utzinger, J" uniqKey="Utzinger J">J. Utzinger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Keiser, J" uniqKey="Keiser J">J. Keiser</name></author><author><name sortKey="Utzinger, J" uniqKey="Utzinger J">J. Utzinger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Keiser, J" uniqKey="Keiser J">J. Keiser</name></author><author><name sortKey="Utzinger, J" uniqKey="Utzinger J">J. Utzinger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Keiser, J" uniqKey="Keiser J">J. Keiser</name></author><author><name sortKey="Utzinger, J" uniqKey="Utzinger J">J. Utzinger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Keiser, J" uniqKey="Keiser J">J. Keiser</name></author><author><name sortKey="Utzinger, J" uniqKey="Utzinger J">J. Utzinger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Keiser, J" uniqKey="Keiser J">J. Keiser</name></author><author><name sortKey="Utzinger, J" uniqKey="Utzinger J">J. Utzinger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Keiser, J" uniqKey="Keiser J">J. Keiser</name></author><author><name sortKey="Engels, D" uniqKey="Engels D">D. Engels</name></author><author><name sortKey="Buscher, G" uniqKey="Buscher G">G. Büscher</name></author><author><name sortKey="Utzinger, J" uniqKey="Utzinger J">J. Utzinger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Keiser, J" uniqKey="Keiser J">J. Keiser</name></author><author><name sortKey="Brun, R" uniqKey="Brun R">R. Brun</name></author><author><name sortKey="Fried, B" uniqKey="Fried B">B. Fried</name></author><author><name sortKey="Utzinger, J" uniqKey="Utzinger J">J. Utzinger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Keiser, J" uniqKey="Keiser J">J. Keiser</name></author><author><name sortKey="Utzinger, J" uniqKey="Utzinger J">J. Utzinger</name></author><author><name sortKey="Tanner, M" uniqKey="Tanner M">M. Tanner</name></author><author><name sortKey="Dong, Y" uniqKey="Dong Y">Y. Dong</name></author><author><name sortKey="Vennerstrom, J L" uniqKey="Vennerstrom J">J.L. Vennerstrom</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Keiser, J" uniqKey="Keiser J">J. Keiser</name></author><author><name sortKey="Xiao, S H" uniqKey="Xiao S">S.H. Xiao</name></author><author><name sortKey="Tanner, M" uniqKey="Tanner M">M. Tanner</name></author><author><name sortKey="Utzinger, J" uniqKey="Utzinger J">J. Utzinger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Keiser, J" uniqKey="Keiser J">J. Keiser</name></author><author><name sortKey="Xiao, S H" uniqKey="Xiao S">S.H. Xiao</name></author><author><name sortKey="Xue, J" uniqKey="Xue J">J. Xue</name></author><author><name sortKey="Chan, Z S" uniqKey="Chan Z">Z.S. Chan</name></author><author><name sortKey="Odermatt, P" uniqKey="Odermatt P">P. Odermatt</name></author><author><name sortKey="Tesana, S" uniqKey="Tesana S">S. Tesana</name></author><author><name sortKey="Tanner, M" uniqKey="Tanner M">M. Tanner</name></author><author><name sortKey="Utzinger, J" uniqKey="Utzinger J">J. Utzinger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Keiser, J" uniqKey="Keiser J">J. Keiser</name></author><author><name sortKey="Utzinger, J" uniqKey="Utzinger J">J. Utzinger</name></author><author><name sortKey="Vennerstrom, J L" uniqKey="Vennerstrom J">J.L. Vennerstrom</name></author><author><name sortKey="Dong, Y" uniqKey="Dong Y">Y. Dong</name></author><author><name sortKey="Brennan, G" uniqKey="Brennan G">G. Brennan</name></author><author><name sortKey="Fairweather, I" uniqKey="Fairweather I">I. Fairweather</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Keiser, J" uniqKey="Keiser J">J. Keiser</name></author><author><name sortKey="Xiao, S H" uniqKey="Xiao S">S.H. Xiao</name></author><author><name sortKey="Chollet, J" uniqKey="Chollet J">J. Chollet</name></author><author><name sortKey="Tanner, M" uniqKey="Tanner M">M. Tanner</name></author><author><name sortKey="Utzinger, J" uniqKey="Utzinger J">J. Utzinger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Keiser, J" uniqKey="Keiser J">J. Keiser</name></author><author><name sortKey="Rinaldi, L" uniqKey="Rinaldi L">L. Rinaldi</name></author><author><name sortKey="Veneziano, V" uniqKey="Veneziano V">V. Veneziano</name></author><author><name sortKey="Mezzino, L" uniqKey="Mezzino L">L. Mezzino</name></author><author><name sortKey="Tanner, M" uniqKey="Tanner M">M. Tanner</name></author><author><name sortKey="Utzinger, J" uniqKey="Utzinger J">J. Utzinger</name></author><author><name sortKey="Cringoli, G" uniqKey="Cringoli G">G. Cringoli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Keiser, J" uniqKey="Keiser J">J. Keiser</name></author><author><name sortKey="Thiemann, K" uniqKey="Thiemann K">K. Thiemann</name></author><author><name sortKey="Endriss, Y" uniqKey="Endriss Y">Y. Endriss</name></author><author><name sortKey="Utzinger, J" uniqKey="Utzinger J">J. Utzinger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Keiser, J" uniqKey="Keiser J">J. Keiser</name></author><author><name sortKey="Odermatt, P" uniqKey="Odermatt P">P. Odermatt</name></author><author><name sortKey="Tesana, S" uniqKey="Tesana S">S. Tesana</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Keiser, J" uniqKey="Keiser J">J. Keiser</name></author><author><name sortKey="Xiao, S H" uniqKey="Xiao S">S.H. Xiao</name></author><author><name sortKey="Smith, T A" uniqKey="Smith T">T.A. Smith</name></author><author><name sortKey="Utzinger, J" uniqKey="Utzinger J">J. Utzinger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Keiser, J" uniqKey="Keiser J">J. Keiser</name></author><author><name sortKey="Duthaler, U" uniqKey="Duthaler U">U. Duthaler</name></author><author><name sortKey="Utzinger, J" uniqKey="Utzinger J">J. Utzinger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Keiser, J" uniqKey="Keiser J">J. Keiser</name></author><author><name sortKey="Kirchhofer, C" uniqKey="Kirchhofer C">C. Kirchhofer</name></author><author><name sortKey="Haschke, M" uniqKey="Haschke M">M. Haschke</name></author><author><name sortKey="Huwyler, J" uniqKey="Huwyler J">J. Huwyler</name></author><author><name sortKey="Dong, Y" uniqKey="Dong Y">Y. Dong</name></author><author><name sortKey="Vennerstrom, J L" uniqKey="Vennerstrom J">J.L. Vennerstrom</name></author><author><name sortKey="Vanhoff, K" uniqKey="Vanhoff K">K. Vanhoff</name></author><author><name sortKey="Kaminsky, R" uniqKey="Kaminsky R">R. Kaminsky</name></author><author><name sortKey="Malikides, N" uniqKey="Malikides N">N. Malikides</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Keiser, J" uniqKey="Keiser J">J. Keiser</name></author><author><name sortKey="N Uessan, N A" uniqKey="N Uessan N">N.A. N’Guessan</name></author><author><name sortKey="Adoubryn, K D" uniqKey="Adoubryn K">K.D. Adoubryn</name></author><author><name sortKey="Silue, K D" uniqKey="Silue K">K.D. Silue</name></author><author><name sortKey="Vounatsou, P" uniqKey="Vounatsou P">P. Vounatsou</name></author><author><name sortKey="Hatz, C" uniqKey="Hatz C">C. Hatz</name></author><author><name sortKey="Utzinger, J" uniqKey="Utzinger J">J. Utzinger</name></author><author><name sortKey="N Oran, E K" uniqKey="N Oran E">E.K. N’Goran</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Keiser, J" uniqKey="Keiser J">J. Keiser</name></author><author><name sortKey="Vargas, M" uniqKey="Vargas M">M. Vargas</name></author><author><name sortKey="Vennerstrom, J L" uniqKey="Vennerstrom J">J.L. Vennerstrom</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Keiser, J" uniqKey="Keiser J">J. Keiser</name></author><author><name sortKey="Veneziano, V" uniqKey="Veneziano V">V. Veneziano</name></author><author><name sortKey="Rinaldi, L" uniqKey="Rinaldi L">L. Rinaldi</name></author><author><name sortKey="Mezzino, L" uniqKey="Mezzino L">L. Mezzino</name></author><author><name sortKey="Duthaler, U" uniqKey="Duthaler U">U. Duthaler</name></author><author><name sortKey="Cringoli, G" uniqKey="Cringoli G">G. Cringoli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Keiser, J" uniqKey="Keiser J">J. Keiser</name></author><author><name sortKey="Sayed, H" uniqKey="Sayed H">H. Sayed</name></author><author><name sortKey="El Ghanam, M" uniqKey="El Ghanam M">M. El-Ghanam</name></author><author><name sortKey="Sabry, H" uniqKey="Sabry H">H. Sabry</name></author><author><name sortKey="Anani, S" uniqKey="Anani S">S. Anani</name></author><author><name sortKey="El Wakeel, A" uniqKey="El Wakeel A">A. El-Wakeel</name></author><author><name sortKey="Hatz, C" uniqKey="Hatz C">C. Hatz</name></author><author><name sortKey="Utzinger, J" uniqKey="Utzinger J">J. Utzinger</name></author><author><name sortKey="El Din, S S" uniqKey="El Din S">S.S. El-Din</name></author><author><name sortKey="El Maadawy, W" uniqKey="El Maadawy W">W. El-Maadawy</name></author><author><name sortKey="Botros, S" uniqKey="Botros S">S. Botros</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Keiser, J" uniqKey="Keiser J">J. Keiser</name></author><author><name sortKey="Ingram, K" uniqKey="Ingram K">K. Ingram</name></author><author><name sortKey="Vargas, M" uniqKey="Vargas M">M. Vargas</name></author><author><name sortKey="Chollet, J" uniqKey="Chollet J">J. Chollet</name></author><author><name sortKey="Wang, X" uniqKey="Wang X">X. Wang</name></author><author><name sortKey="Dong, Y" uniqKey="Dong Y">Y. Dong</name></author><author><name sortKey="Vennerstrom, J L" uniqKey="Vennerstrom J">J.L. Vennerstrom</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Keiser, J" uniqKey="Keiser J">J. Keiser</name></author><author><name sortKey="Tritten, L" uniqKey="Tritten L">L. Tritten</name></author><author><name sortKey="Adelfio, R" uniqKey="Adelfio R">R. Adelfio</name></author><author><name sortKey="Vargas, M" uniqKey="Vargas M">M. Vargas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Keiser, J" uniqKey="Keiser J">J. Keiser</name></author><author><name sortKey="Adelfio, R" uniqKey="Adelfio R">R. Adelfio</name></author><author><name sortKey="Vargas, M" uniqKey="Vargas M">M. Vargas</name></author><author><name sortKey="Odermatt, P" uniqKey="Odermatt P">P. Odermatt</name></author><author><name sortKey="Tesana, S" uniqKey="Tesana S">S. Tesana</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Keiser, J" uniqKey="Keiser J">J. Keiser</name></author><author><name sortKey="Tritten, L" uniqKey="Tritten L">L. Tritten</name></author><author><name sortKey="Silbereisen, A" uniqKey="Silbereisen A">A. Silbereisen</name></author><author><name sortKey="Speich, B" uniqKey="Speich B">B. Speich</name></author><author><name sortKey="Adelfio, R" uniqKey="Adelfio R">R. Adelfio</name></author><author><name sortKey="Vargas, M" uniqKey="Vargas M">M. Vargas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kern, P" uniqKey="Kern P">P. Kern</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Knopp, S" uniqKey="Knopp S">S. Knopp</name></author><author><name sortKey="Steinmann, P" uniqKey="Steinmann P">P. Steinmann</name></author><author><name sortKey="Hatz, C" uniqKey="Hatz C">C. Hatz</name></author><author><name sortKey="Keiser, J" uniqKey="Keiser J">J. Keiser</name></author><author><name sortKey="Utzinger, J" uniqKey="Utzinger J">J. Utzinger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Knopp, S" uniqKey="Knopp S">S. Knopp</name></author><author><name sortKey="Steinmann, P" uniqKey="Steinmann P">P. Steinmann</name></author><author><name sortKey="Keiser, J" uniqKey="Keiser J">J. Keiser</name></author><author><name sortKey="Utzinger, J" uniqKey="Utzinger J">J. Utzinger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Knopp, S" uniqKey="Knopp S">S. Knopp</name></author><author><name sortKey="Becker, S L" uniqKey="Becker S">S.L. Becker</name></author><author><name sortKey="Ingram, K J" uniqKey="Ingram K">K.J. Ingram</name></author><author><name sortKey="Keiser, J" uniqKey="Keiser J">J. Keiser</name></author><author><name sortKey="Utzinger, J" uniqKey="Utzinger J">J. Utzinger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Koul, P A" uniqKey="Koul P">P.A. Koul</name></author><author><name sortKey="Wahid, A" uniqKey="Wahid A">A. Wahid</name></author><author><name sortKey="Bhat, M H" uniqKey="Bhat M">M.H. Bhat</name></author><author><name sortKey="Wani, J I" uniqKey="Wani J">J.I. Wani</name></author><author><name sortKey="Sofi, B A" uniqKey="Sofi B">B.A. Sofi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kulke, D" uniqKey="Kulke D">D. Kulke</name></author><author><name sortKey="Krucken, J" uniqKey="Krucken J">J. Krucken</name></author><author><name sortKey="Welz, C" uniqKey="Welz C">C. Welz</name></author><author><name sortKey="Von Samson Himmelstjerna, G" uniqKey="Von Samson Himmelstjerna G">G. von Samson-Himmelstjerna</name></author><author><name sortKey="Harder, A" uniqKey="Harder A">A. Harder</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kulke, D" uniqKey="Kulke D">D. Kulke</name></author><author><name sortKey="Krucken, J" uniqKey="Krucken J">J. Krücken</name></author><author><name sortKey="Harder, A" uniqKey="Harder A">A. Harder</name></author><author><name sortKey="Samson Himmelstjerna, G" uniqKey="Samson Himmelstjerna G">G. Samson-Himmelstjerna</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kuster, T" uniqKey="Kuster T">T. Kuster</name></author><author><name sortKey="Stadelmann, B" uniqKey="Stadelmann B">B. Stadelmann</name></author><author><name sortKey="Hermann, C" uniqKey="Hermann C">C. Hermann</name></author><author><name sortKey="Scholl, S" uniqKey="Scholl S">S. Scholl</name></author><author><name sortKey="Keiser, J" uniqKey="Keiser J">J. Keiser</name></author><author><name sortKey="Hemphill, A" uniqKey="Hemphill A">A. Hemphill</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lanusse, C E" uniqKey="Lanusse C">C.E. Lanusse</name></author><author><name sortKey="Virkel, G L" uniqKey="Virkel G">G.L. Virkel</name></author><author><name sortKey="Sanchez, S F" uniqKey="Sanchez S">S.F. Sanchez</name></author><author><name sortKey="Alvarez, L I" uniqKey="Alvarez L">L.I. Alvarez</name></author><author><name sortKey="Lifschitz, A L" uniqKey="Lifschitz A">A.L. Lifschitz</name></author><author><name sortKey="Imperiale, F" uniqKey="Imperiale F">F. Imperiale</name></author><author><name sortKey="Monfrinotti, A" uniqKey="Monfrinotti A">A. Monfrinotti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lateef, M" uniqKey="Lateef M">M. Lateef</name></author><author><name sortKey="Zargar, S A" uniqKey="Zargar S">S.A. Zargar</name></author><author><name sortKey="Khan, A R" uniqKey="Khan A">A.R. Khan</name></author><author><name sortKey="Nazir, M" uniqKey="Nazir M">M. Nazir</name></author><author><name sortKey="Shoukat, A" uniqKey="Shoukat A">A. Shoukat</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, E L" uniqKey="Lee E">E.L. Lee</name></author><author><name sortKey="Iyngkaran, N" uniqKey="Iyngkaran N">N. Iyngkaran</name></author><author><name sortKey="Grieve, A W" uniqKey="Grieve A">A.W. Grieve</name></author><author><name sortKey="Robinson, M J" uniqKey="Robinson M">M.J. Robinson</name></author><author><name sortKey="Dissanaike, A S" uniqKey="Dissanaike A">A.S. Dissanaike</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, S H" uniqKey="Lee S">S.H. Lee</name></author><author><name sortKey="Lim, J K" uniqKey="Lim J">J.K. Lim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, H J" uniqKey="Li H">H.J. Li</name></author><author><name sortKey="Wang, W" uniqKey="Wang W">W. Wang</name></author><author><name sortKey="Qu, G L" uniqKey="Qu G">G.L. Qu</name></author><author><name sortKey="Tao, Y H" uniqKey="Tao Y">Y.H. Tao</name></author><author><name sortKey="Xing, Y T" uniqKey="Xing Y">Y.T. Xing</name></author><author><name sortKey="Li, Y Z" uniqKey="Li Y">Y.Z. Li</name></author><author><name sortKey="Wei, J Y" uniqKey="Wei J">J.Y. Wei</name></author><author><name sortKey="Dai, J R" uniqKey="Dai J">J.R. Dai</name></author><author><name sortKey="Liang, Y S" uniqKey="Liang Y">Y.S. Liang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, H J" uniqKey="Li H">H.J. Li</name></author><author><name sortKey="Wang, W" uniqKey="Wang W">W. Wang</name></author><author><name sortKey="Qu, G L" uniqKey="Qu G">G.L. Qu</name></author><author><name sortKey="Li, Y Z" uniqKey="Li Y">Y.Z. Li</name></author><author><name sortKey="Tao, Y H" uniqKey="Tao Y">Y.H. Tao</name></author><author><name sortKey="Xing, Y T" uniqKey="Xing Y">Y.T. Xing</name></author><author><name sortKey="Wang, X T" uniqKey="Wang X">X.T. Wang</name></author><author><name sortKey="Dai, Y" uniqKey="Dai Y">Y. Dai</name></author><author><name sortKey="Wei, J Y" uniqKey="Wei J">J.Y. Wei</name></author><author><name sortKey="Dai, J R" uniqKey="Dai J">J.R. Dai</name></author><author><name sortKey="Coles, G C" uniqKey="Coles G">G.C. Coles</name></author><author><name sortKey="Liang, Y S" uniqKey="Liang Y">Y.S. Liang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, H J" uniqKey="Li H">H.J. Li</name></author><author><name sortKey="Xu, F L" uniqKey="Xu F">F.L. Xu</name></author><author><name sortKey="Wang, Y H" uniqKey="Wang Y">Y.H. Wang</name></author><author><name sortKey="Yi, Z J" uniqKey="Yi Z">Z.J. Yi</name></author><author><name sortKey="Wang, W" uniqKey="Wang W">W. Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Link, H" uniqKey="Link H">H. Link</name></author><author><name sortKey="Stohler, H R" uniqKey="Stohler H">H.R. Stohler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, R" uniqKey="Liu R">R. Liu</name></author><author><name sortKey="Dong, H F" uniqKey="Dong H">H.F. Dong</name></author><author><name sortKey="Guo, Y" uniqKey="Guo Y">Y. Guo</name></author><author><name sortKey="Zhao, Q P" uniqKey="Zhao Q">Q.P. Zhao</name></author><author><name sortKey="Jiang, M S" uniqKey="Jiang M">M.S. Jiang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lumaret, J P" uniqKey="Lumaret J">J.P. Lumaret</name></author><author><name sortKey="Errouissi, F" uniqKey="Errouissi F">F. Errouissi</name></author><author><name sortKey="Floate, K" uniqKey="Floate K">K. Floate</name></author><author><name sortKey="Rombke, J" uniqKey="Rombke J">J. Rombke</name></author><author><name sortKey="Wardhaugh, K" uniqKey="Wardhaugh K">K. Wardhaugh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lyons, E T" uniqKey="Lyons E">E.T. Lyons</name></author><author><name sortKey="Tolliver, S C" uniqKey="Tolliver S">S.C. Tolliver</name></author><author><name sortKey="Collins, S S" uniqKey="Collins S">S.S. Collins</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mackenzie, C D" uniqKey="Mackenzie C">C.D. Mackenzie</name></author><author><name sortKey="Geary, T G" uniqKey="Geary T">T.G. Geary</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mand, S" uniqKey="Mand S">S. Mand</name></author><author><name sortKey="Pfarr, K" uniqKey="Pfarr K">K. Pfarr</name></author><author><name sortKey="Sahoo, P K" uniqKey="Sahoo P">P.K. Sahoo</name></author><author><name sortKey="Satapathy, A K" uniqKey="Satapathy A">A.K. Satapathy</name></author><author><name sortKey="Specht, S" uniqKey="Specht S">S. Specht</name></author><author><name sortKey="Klarmann, U" uniqKey="Klarmann U">U. Klarmann</name></author><author><name sortKey="Debrah, A Y" uniqKey="Debrah A">A.Y. Debrah</name></author><author><name sortKey="Ravindran, B" uniqKey="Ravindran B">B. Ravindran</name></author><author><name sortKey="Hoerauf, A" uniqKey="Hoerauf A">A. Hoerauf</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mand, S" uniqKey="Mand S">S. Mand</name></author><author><name sortKey="Debrah, A Y" uniqKey="Debrah A">A.Y. Debrah</name></author><author><name sortKey="Klarmann, U" uniqKey="Klarmann U">U. Klarmann</name></author><author><name sortKey="Batsa, L" uniqKey="Batsa L">L. Batsa</name></author><author><name sortKey="Marfo Debrekyei, Y" uniqKey="Marfo Debrekyei Y">Y. Marfo-Debrekyei</name></author><author><name sortKey="Kwarteng, A" uniqKey="Kwarteng A">A. Kwarteng</name></author><author><name sortKey="Specht, S" uniqKey="Specht S">S. Specht</name></author><author><name sortKey="Belda Domene, A" uniqKey="Belda Domene A">A. Belda-Domene</name></author><author><name sortKey="Fimmers, R" uniqKey="Fimmers R">R. Fimmers</name></author><author><name sortKey="Taylor, M" uniqKey="Taylor M">M. Taylor</name></author><author><name sortKey="Adjei, O" uniqKey="Adjei O">O. Adjei</name></author><author><name sortKey="Hoerauf, A" uniqKey="Hoerauf A">A. Hoerauf</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mansour Ghanaei, F" uniqKey="Mansour Ghanaei F">F. Mansour-Ghanaei</name></author><author><name sortKey="Shafaghi, A" uniqKey="Shafaghi A">A. Shafaghi</name></author><author><name sortKey="Fallah, M" uniqKey="Fallah M">M. Fallah</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Masud, H" uniqKey="Masud H">H. Masud</name></author><author><name sortKey="Qureshi, T Q" uniqKey="Qureshi T">T.Q. Qureshi</name></author><author><name sortKey="Dukley, M" uniqKey="Dukley M">M. Dukley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mcmahon, J E" uniqKey="Mcmahon J">J.E. McMahon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Meister, I" uniqKey="Meister I">I. Meister</name></author><author><name sortKey="Duthaler, U" uniqKey="Duthaler U">U. Duthaler</name></author><author><name sortKey="Huwyler, J" uniqKey="Huwyler J">J. Huwyler</name></author><author><name sortKey="Rinaldi, L" uniqKey="Rinaldi L">L. Rinaldi</name></author><author><name sortKey="Bosco, A" uniqKey="Bosco A">A. Bosco</name></author><author><name sortKey="Cringoli, G" uniqKey="Cringoli G">G. Cringoli</name></author><author><name sortKey="Keiser, J" uniqKey="Keiser J">J. Keiser</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mossallam, S F" uniqKey="Mossallam S">S.F. Mossallam</name></author><author><name sortKey="Ali, S M" uniqKey="Ali S">S.M. Ali</name></author><author><name sortKey="El Zawawy, L A" uniqKey="El Zawawy L">L.A. El Zawawy</name></author><author><name sortKey="Said, D E" uniqKey="Said D">D.E. Said</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Murray, C J" uniqKey="Murray C">C.J. Murray</name></author><author><name sortKey="Vos, T" uniqKey="Vos T">T. Vos</name></author><author><name sortKey="Lozano, R" uniqKey="Lozano R">R. Lozano</name></author><author><name sortKey="Naghavi, M" uniqKey="Naghavi M">M. Naghavi</name></author><author><name sortKey="Flaxman, A D" uniqKey="Flaxman A">A.D. Flaxman</name></author><author><name sortKey="Michaud, C" uniqKey="Michaud C">C. Michaud</name></author><author><name sortKey="Ezzati, M" uniqKey="Ezzati M">M. Ezzati</name></author><author><name sortKey="Shibuya, K" uniqKey="Shibuya K">K. Shibuya</name></author><author><name sortKey="Salomon, J A" uniqKey="Salomon J">J.A. Salomon</name></author><author><name sortKey="Abdalla, S" uniqKey="Abdalla S">S. Abdalla</name></author><author><name sortKey="Aboyans, V" uniqKey="Aboyans V">V. Aboyans</name></author><author><name sortKey="Abraham, J" uniqKey="Abraham J">J. Abraham</name></author><author><name sortKey="Ackerman, I" uniqKey="Ackerman I">I. Ackerman</name></author><author><name sortKey="Aggarwal, R" uniqKey="Aggarwal R">R. Aggarwal</name></author><author><name sortKey="Ahn, S Y" uniqKey="Ahn S">S.Y. Ahn</name></author><author><name sortKey="Ali, M K" uniqKey="Ali M">M.K. Ali</name></author><author><name sortKey="Alvarado, M" uniqKey="Alvarado M">M. Alvarado</name></author><author><name sortKey="Anderson, H R" uniqKey="Anderson H">H.R. Anderson</name></author><author><name sortKey="Anderson, L M" uniqKey="Anderson L">L.M. Anderson</name></author><author><name sortKey="Andrews, K G" uniqKey="Andrews K">K.G. Andrews</name></author><author><name sortKey="Atkinson, C" uniqKey="Atkinson C">C. Atkinson</name></author><author><name sortKey="Baddour, L M" uniqKey="Baddour L">L.M. Baddour</name></author><author><name sortKey="Bahalim, A N" uniqKey="Bahalim A">A.N. Bahalim</name></author><author><name sortKey="Barker Collo, S" uniqKey="Barker Collo S">S. Barker-Collo</name></author><author><name sortKey="Barrero, L H" uniqKey="Barrero L">L.H. Barrero</name></author><author><name sortKey="Bartels, D H" uniqKey="Bartels D">D.H. Bartels</name></author><author><name sortKey="Basanez, M G" uniqKey="Basanez M">M.G. Basanez</name></author><author><name sortKey="Baxter, A" uniqKey="Baxter A">A. Baxter</name></author><author><name sortKey="Bell, M L" uniqKey="Bell M">M.L. Bell</name></author><author><name sortKey="Benjamin, E J" uniqKey="Benjamin E">E.J. Benjamin</name></author><author><name sortKey="Bennett, D" uniqKey="Bennett D">D. Bennett</name></author><author><name sortKey="Bernabe, E" uniqKey="Bernabe E">E. Bernabe</name></author><author><name sortKey="Bhalla, K" uniqKey="Bhalla K">K. Bhalla</name></author><author><name sortKey="Bhandari, B" uniqKey="Bhandari B">B. Bhandari</name></author><author><name sortKey="Bikbov, B" uniqKey="Bikbov B">B. Bikbov</name></author><author><name sortKey="Bin Abdulhak, A" uniqKey="Bin Abdulhak A">A. Bin Abdulhak</name></author><author><name sortKey="Birbeck, G" uniqKey="Birbeck G">G. Birbeck</name></author><author><name sortKey="Black, J A" uniqKey="Black J">J.A. Black</name></author><author><name sortKey="Blencowe, H" uniqKey="Blencowe H">H. Blencowe</name></author><author><name sortKey="Blore, J D" uniqKey="Blore J">J.D. Blore</name></author><author><name sortKey="Blyth, F" uniqKey="Blyth F">F. Blyth</name></author><author><name sortKey="Bolliger, I" uniqKey="Bolliger I">I. Bolliger</name></author><author><name sortKey="Bonaventure, A" uniqKey="Bonaventure A">A. Bonaventure</name></author><author><name sortKey="Boufous, S" uniqKey="Boufous S">S. Boufous</name></author><author><name sortKey="Bourne, R" uniqKey="Bourne R">R. Bourne</name></author><author><name sortKey="Boussinesq, M" uniqKey="Boussinesq M">M. Boussinesq</name></author><author><name sortKey="Braithwaite, T" uniqKey="Braithwaite T">T. Braithwaite</name></author><author><name sortKey="Brayne, C" uniqKey="Brayne C">C. Brayne</name></author><author><name sortKey="Bridgett, L" uniqKey="Bridgett L">L. Bridgett</name></author><author><name sortKey="Brooker, S" uniqKey="Brooker S">S. Brooker</name></author><author><name sortKey="Brooks, P" uniqKey="Brooks P">P. Brooks</name></author><author><name sortKey="Brugha, T S" uniqKey="Brugha T">T.S. Brugha</name></author><author><name sortKey="Bryan Hancock, C" uniqKey="Bryan Hancock C">C. Bryan-Hancock</name></author><author><name sortKey="Bucello, C" uniqKey="Bucello C">C. Bucello</name></author><author><name sortKey="Buchbinder, R" uniqKey="Buchbinder R">R. Buchbinder</name></author><author><name sortKey="Buckle, G" uniqKey="Buckle G">G. Buckle</name></author><author><name sortKey="Budke, C M" uniqKey="Budke C">C.M. Budke</name></author><author><name sortKey="Burch, M" uniqKey="Burch M">M. Burch</name></author><author><name sortKey="Burney, P" uniqKey="Burney P">P. Burney</name></author><author><name sortKey="Burstein, R" uniqKey="Burstein R">R. Burstein</name></author><author><name sortKey="Calabria, B" uniqKey="Calabria B">B. Calabria</name></author><author><name sortKey="Campbell, B" uniqKey="Campbell B">B. Campbell</name></author><author><name sortKey="Canter, C E" uniqKey="Canter C">C.E. Canter</name></author><author><name sortKey="Carabin, H" uniqKey="Carabin H">H. Carabin</name></author><author><name sortKey="Carapetis, J" uniqKey="Carapetis J">J. Carapetis</name></author><author><name sortKey="Carmona, L" uniqKey="Carmona L">L. Carmona</name></author><author><name sortKey="Cella, C" uniqKey="Cella C">C. Cella</name></author><author><name sortKey="Charlson, F" uniqKey="Charlson F">F. Charlson</name></author><author><name sortKey="Chen, H" uniqKey="Chen H">H. Chen</name></author><author><name sortKey="Cheng, A T" uniqKey="Cheng A">A.T. Cheng</name></author><author><name sortKey="Chou, D" uniqKey="Chou D">D. Chou</name></author><author><name sortKey="Chugh, S S" uniqKey="Chugh S">S.S. Chugh</name></author><author><name sortKey="Coffeng, L E" uniqKey="Coffeng L">L.E. Coffeng</name></author><author><name sortKey="Colan, S D" uniqKey="Colan S">S.D. Colan</name></author><author><name sortKey="Colquhoun, S" uniqKey="Colquhoun S">S. Colquhoun</name></author><author><name sortKey="Colson, K E" uniqKey="Colson K">K.E. Colson</name></author><author><name sortKey="Condon, J" uniqKey="Condon J">J. Condon</name></author><author><name sortKey="Connor, M D" uniqKey="Connor M">M.D. Connor</name></author><author><name sortKey="Cooper, L T" uniqKey="Cooper L">L.T. Cooper</name></author><author><name sortKey="Corriere, M" uniqKey="Corriere M">M. Corriere</name></author><author><name sortKey="Cortinovis, M" uniqKey="Cortinovis M">M. Cortinovis</name></author><author><name sortKey="De Vaccaro, K C" uniqKey="De Vaccaro K">K.C. de Vaccaro</name></author><author><name sortKey="Couser, W" uniqKey="Couser W">W. Couser</name></author><author><name sortKey="Cowie, B C" uniqKey="Cowie B">B.C. Cowie</name></author><author><name sortKey="Criqui, M H" uniqKey="Criqui M">M.H. Criqui</name></author><author><name sortKey="Cross, M" uniqKey="Cross M">M. Cross</name></author><author><name sortKey="Dabhadkar, K C" uniqKey="Dabhadkar K">K.C. Dabhadkar</name></author><author><name sortKey="Dahiya, M" uniqKey="Dahiya M">M. Dahiya</name></author><author><name sortKey="Dahodwala, N" uniqKey="Dahodwala N">N. Dahodwala</name></author><author><name sortKey="Damsere Derry, J" uniqKey="Damsere Derry J">J. Damsere-Derry</name></author><author><name sortKey="Danaei, G" uniqKey="Danaei G">G. Danaei</name></author><author><name sortKey="Davis, A" uniqKey="Davis A">A. Davis</name></author><author><name sortKey="De Leo, D" uniqKey="De Leo D">D. De Leo</name></author><author><name sortKey="Degenhardt, L" uniqKey="Degenhardt L">L. Degenhardt</name></author><author><name sortKey="Dellavalle, R" uniqKey="Dellavalle R">R. Dellavalle</name></author><author><name sortKey="Delossantos, A" uniqKey="Delossantos A">A. Delossantos</name></author><author><name sortKey="Denenberg, J" uniqKey="Denenberg J">J. Denenberg</name></author><author><name sortKey="Derrett, S" uniqKey="Derrett S">S. Derrett</name></author><author><name sortKey="Des Jarlais, D C" uniqKey="Des Jarlais D">D.C. Des Jarlais</name></author><author><name sortKey="Dharmaratne, S D" uniqKey="Dharmaratne S">S.D. Dharmaratne</name></author><author><name sortKey="Dherani, M" uniqKey="Dherani M">M. Dherani</name></author><author><name sortKey="Diaz Torne, C" uniqKey="Diaz Torne C">C. Diaz-Torne</name></author><author><name sortKey="Dolk, H" uniqKey="Dolk H">H. Dolk</name></author><author><name sortKey="Dorsey, E R" uniqKey="Dorsey E">E.R. Dorsey</name></author><author><name sortKey="Driscoll, T" uniqKey="Driscoll T">T. Driscoll</name></author><author><name sortKey="Duber, H" uniqKey="Duber H">H. Duber</name></author><author><name sortKey="Ebel, B" uniqKey="Ebel B">B. Ebel</name></author><author><name sortKey="Edmond, K" uniqKey="Edmond K">K. Edmond</name></author><author><name sortKey="Elbaz, A" uniqKey="Elbaz A">A. Elbaz</name></author><author><name sortKey="Ali, S E" uniqKey="Ali S">S.E. Ali</name></author><author><name sortKey="Erskine, H" uniqKey="Erskine H">H. Erskine</name></author><author><name sortKey="Erwin, P J" uniqKey="Erwin P">P.J. Erwin</name></author><author><name sortKey="Espindola, P" uniqKey="Espindola P">P. Espindola</name></author><author><name sortKey="Ewoigbokhan, S E" uniqKey="Ewoigbokhan S">S.E. Ewoigbokhan</name></author><author><name sortKey="Farzadfar, F" uniqKey="Farzadfar F">F. Farzadfar</name></author><author><name sortKey="Feigin, V" uniqKey="Feigin V">V. Feigin</name></author><author><name sortKey="Felson, D T" uniqKey="Felson D">D.T. Felson</name></author><author><name sortKey="Ferrari, A" uniqKey="Ferrari A">A. Ferrari</name></author><author><name sortKey="Ferri, C P" uniqKey="Ferri C">C.P. Ferri</name></author><author><name sortKey="Fevre, E M" uniqKey="Fevre E">E.M. Fevre</name></author><author><name sortKey="Finucane, M M" uniqKey="Finucane M">M.M. Finucane</name></author><author><name sortKey="Flaxman, S" uniqKey="Flaxman S">S. Flaxman</name></author><author><name sortKey="Flood, L" uniqKey="Flood L">L. Flood</name></author><author><name sortKey="Foreman, K" uniqKey="Foreman K">K. Foreman</name></author><author><name sortKey="Forouzanfar, M H" uniqKey="Forouzanfar M">M.H. Forouzanfar</name></author><author><name sortKey="Fowkes, F G" uniqKey="Fowkes F">F.G. Fowkes</name></author><author><name sortKey="Fransen, M" uniqKey="Fransen M">M. Fransen</name></author><author><name sortKey="Freeman, M K" uniqKey="Freeman M">M.K. Freeman</name></author><author><name sortKey="Gabbe, B J" uniqKey="Gabbe B">B.J. Gabbe</name></author><author><name sortKey="Gabriel, S E" uniqKey="Gabriel S">S.E. Gabriel</name></author><author><name sortKey="Gakidou, E" uniqKey="Gakidou E">E. Gakidou</name></author><author><name sortKey="Ganatra, H A" uniqKey="Ganatra H">H.A. Ganatra</name></author><author><name sortKey="Garcia, B" uniqKey="Garcia B">B. Garcia</name></author><author><name sortKey="Gaspari, F" uniqKey="Gaspari F">F. Gaspari</name></author><author><name sortKey="Gillum, R F" uniqKey="Gillum R">R.F. Gillum</name></author><author><name sortKey="Gmel, G" uniqKey="Gmel G">G. Gmel</name></author><author><name sortKey="Gonzalez Medina, D" uniqKey="Gonzalez Medina D">D. Gonzalez-Medina</name></author><author><name sortKey="Gosselin, R" uniqKey="Gosselin R">R. Gosselin</name></author><author><name sortKey="Grainger, R" uniqKey="Grainger R">R. Grainger</name></author><author><name sortKey="Grant, B" uniqKey="Grant B">B. Grant</name></author><author><name sortKey="Groeger, J" uniqKey="Groeger J">J. Groeger</name></author><author><name sortKey="Guillemin, F" uniqKey="Guillemin F">F. Guillemin</name></author><author><name sortKey="Gunnell, D" uniqKey="Gunnell D">D. Gunnell</name></author><author><name sortKey="Gupta, R" uniqKey="Gupta R">R. Gupta</name></author><author><name sortKey="Haagsma, J" uniqKey="Haagsma J">J. Haagsma</name></author><author><name sortKey="Hagan, H" uniqKey="Hagan H">H. Hagan</name></author><author><name sortKey="Halasa, Y A" uniqKey="Halasa Y">Y.A. Halasa</name></author><author><name sortKey="Hall, W" uniqKey="Hall W">W. Hall</name></author><author><name sortKey="Haring, D" uniqKey="Haring D">D. Haring</name></author><author><name sortKey="Haro, J M" uniqKey="Haro J">J.M. Haro</name></author><author><name sortKey="Harrison, J E" uniqKey="Harrison J">J.E. Harrison</name></author><author><name sortKey="Havmoeller, R" uniqKey="Havmoeller R">R. Havmoeller</name></author><author><name sortKey="Hay, R J" uniqKey="Hay R">R.J. Hay</name></author><author><name sortKey="Higashi, H" uniqKey="Higashi H">H. Higashi</name></author><author><name sortKey="Hill, C" uniqKey="Hill C">C. Hill</name></author><author><name sortKey="Hoen, B" uniqKey="Hoen B">B. Hoen</name></author><author><name sortKey="Hoffman, H" uniqKey="Hoffman H">H. Hoffman</name></author><author><name sortKey="Hotez, P J" uniqKey="Hotez P">P.J. Hotez</name></author><author><name sortKey="Hoy, D" uniqKey="Hoy D">D. Hoy</name></author><author><name sortKey="Huang, J J" uniqKey="Huang J">J.J. Huang</name></author><author><name sortKey="Ibeanusi, S E" uniqKey="Ibeanusi S">S.E. Ibeanusi</name></author><author><name sortKey="Jacobsen, K H" uniqKey="Jacobsen K">K.H. Jacobsen</name></author><author><name sortKey="James, S L" uniqKey="James S">S.L. James</name></author><author><name sortKey="Jarvis, D" uniqKey="Jarvis D">D. Jarvis</name></author><author><name sortKey="Jasrasaria, R" uniqKey="Jasrasaria R">R. Jasrasaria</name></author><author><name sortKey="Jayaraman, S" uniqKey="Jayaraman S">S. Jayaraman</name></author><author><name sortKey="Johns, N" uniqKey="Johns N">N. Johns</name></author><author><name sortKey="Jonas, J B" uniqKey="Jonas J">J.B. Jonas</name></author><author><name sortKey="Karthikeyan, G" uniqKey="Karthikeyan G">G. Karthikeyan</name></author><author><name sortKey="Kassebaum, N" uniqKey="Kassebaum N">N. Kassebaum</name></author><author><name sortKey="Kawakami, N" uniqKey="Kawakami N">N. Kawakami</name></author><author><name sortKey="Keren, A" uniqKey="Keren A">A. Keren</name></author><author><name sortKey="Khoo, J P" uniqKey="Khoo J">J.P. Khoo</name></author><author><name sortKey="King, C H" uniqKey="King C">C.H. King</name></author><author><name sortKey="Knowlton, L M" uniqKey="Knowlton L">L.M. Knowlton</name></author><author><name sortKey="Kobusingye, O" uniqKey="Kobusingye O">O. Kobusingye</name></author><author><name sortKey="Koranteng, A" uniqKey="Koranteng A">A. Koranteng</name></author><author><name sortKey="Krishnamurthi, R" uniqKey="Krishnamurthi R">R. Krishnamurthi</name></author><author><name sortKey="Laden, F" uniqKey="Laden F">F. Laden</name></author><author><name sortKey="Lalloo, R" uniqKey="Lalloo R">R. Lalloo</name></author><author><name sortKey="Laslett, L L" uniqKey="Laslett L">L.L. Laslett</name></author><author><name sortKey="Lathlean, T" uniqKey="Lathlean T">T. Lathlean</name></author><author><name sortKey="Leasher, J L" uniqKey="Leasher J">J.L. Leasher</name></author><author><name sortKey="Lee, Y Y" uniqKey="Lee Y">Y.Y. Lee</name></author><author><name sortKey="Leigh, J" uniqKey="Leigh J">J. Leigh</name></author><author><name sortKey="Levinson, D" uniqKey="Levinson D">D. Levinson</name></author><author><name sortKey="Lim, S S" uniqKey="Lim S">S.S. Lim</name></author><author><name sortKey="Limb, E" uniqKey="Limb E">E. Limb</name></author><author><name sortKey="Lin, J K" uniqKey="Lin J">J.K. Lin</name></author><author><name sortKey="Lipnick, M" uniqKey="Lipnick M">M. Lipnick</name></author><author><name sortKey="Lipshultz, S E" uniqKey="Lipshultz S">S.E. Lipshultz</name></author><author><name sortKey="Liu, W" uniqKey="Liu W">W. Liu</name></author><author><name sortKey="Loane, M" uniqKey="Loane M">M. Loane</name></author><author><name sortKey="Ohno, S L" uniqKey="Ohno S">S.L. Ohno</name></author><author><name sortKey="Lyons, R" uniqKey="Lyons R">R. Lyons</name></author><author><name sortKey="Mabweijano, J" uniqKey="Mabweijano J">J. Mabweijano</name></author><author><name sortKey="Macintyre, M F" uniqKey="Macintyre M">M.F. MacIntyre</name></author><author><name sortKey="Malekzadeh, R" uniqKey="Malekzadeh R">R. Malekzadeh</name></author><author><name sortKey="Mallinger, L" uniqKey="Mallinger L">L. Mallinger</name></author><author><name sortKey="Manivannan, S" uniqKey="Manivannan S">S. Manivannan</name></author><author><name sortKey="Marcenes, W" uniqKey="Marcenes W">W. Marcenes</name></author><author><name sortKey="March, L" uniqKey="March L">L. March</name></author><author><name sortKey="Margolis, D J" uniqKey="Margolis D">D.J. Margolis</name></author><author><name sortKey="Marks, G B" uniqKey="Marks G">G.B. Marks</name></author><author><name sortKey="Marks, R" uniqKey="Marks R">R. Marks</name></author><author><name sortKey="Matsumori, A" uniqKey="Matsumori A">A. Matsumori</name></author><author><name sortKey="Matzopoulos, R" uniqKey="Matzopoulos R">R. Matzopoulos</name></author><author><name sortKey="Mayosi, B M" uniqKey="Mayosi B">B.M. Mayosi</name></author><author><name sortKey="Mcanulty, J H" uniqKey="Mcanulty J">J.H. McAnulty</name></author><author><name sortKey="Mcdermott, M M" uniqKey="Mcdermott M">M.M. McDermott</name></author><author><name sortKey="Mcgill, N" uniqKey="Mcgill N">N. McGill</name></author><author><name sortKey="Mcgrath, J" uniqKey="Mcgrath J">J. McGrath</name></author><author><name sortKey="Medina Mora, M E" uniqKey="Medina Mora M">M.E. Medina-Mora</name></author><author><name sortKey="Meltzer, M" uniqKey="Meltzer M">M. Meltzer</name></author><author><name sortKey="Mensah, G A" uniqKey="Mensah G">G.A. Mensah</name></author><author><name sortKey="Merriman, T R" uniqKey="Merriman T">T.R. Merriman</name></author><author><name sortKey="Meyer, A C" uniqKey="Meyer A">A.C. Meyer</name></author><author><name sortKey="Miglioli, V" uniqKey="Miglioli V">V. Miglioli</name></author><author><name sortKey="Miller, M" uniqKey="Miller M">M. Miller</name></author><author><name sortKey="Miller, T R" uniqKey="Miller T">T.R. Miller</name></author><author><name sortKey="Mitchell, P B" uniqKey="Mitchell P">P.B. Mitchell</name></author><author><name sortKey="Mock, C" uniqKey="Mock C">C. Mock</name></author><author><name sortKey="Mocumbi, A O" uniqKey="Mocumbi A">A.O. Mocumbi</name></author><author><name sortKey="Moffitt, T E" uniqKey="Moffitt T">T.E. Moffitt</name></author><author><name sortKey="Mokdad, A A" uniqKey="Mokdad A">A.A. Mokdad</name></author><author><name sortKey="Monasta, L" uniqKey="Monasta L">L. Monasta</name></author><author><name sortKey="Montico, M" uniqKey="Montico M">M. Montico</name></author><author><name sortKey="Moradi Lakeh, M" uniqKey="Moradi Lakeh M">M. Moradi-Lakeh</name></author><author><name sortKey="Moran, A" uniqKey="Moran A">A. Moran</name></author><author><name sortKey="Morawska, L" uniqKey="Morawska L">L. Morawska</name></author><author><name sortKey="Mori, R" uniqKey="Mori R">R. Mori</name></author><author><name sortKey="Murdoch, M E" uniqKey="Murdoch M">M.E. Murdoch</name></author><author><name sortKey="Mwaniki, M K" uniqKey="Mwaniki M">M.K. Mwaniki</name></author><author><name sortKey="Naidoo, K" uniqKey="Naidoo K">K. Naidoo</name></author><author><name sortKey="Nair, M N" uniqKey="Nair M">M.N. Nair</name></author><author><name sortKey="Naldi, L" uniqKey="Naldi L">L. Naldi</name></author><author><name sortKey="Narayan, K M" uniqKey="Narayan K">K.M. Narayan</name></author><author><name sortKey="Nelson, P K" uniqKey="Nelson P">P.K. Nelson</name></author><author><name sortKey="Nelson, R G" uniqKey="Nelson R">R.G. Nelson</name></author><author><name sortKey="Nevitt, M C" uniqKey="Nevitt M">M.C. Nevitt</name></author><author><name sortKey="Newton, C R" uniqKey="Newton C">C.R. Newton</name></author><author><name sortKey="Nolte, S" uniqKey="Nolte S">S. Nolte</name></author><author><name sortKey="Norman, P" uniqKey="Norman P">P. Norman</name></author><author><name sortKey="Norman, R" uniqKey="Norman R">R. Norman</name></author><author><name sortKey="O Onnell, M" uniqKey="O Onnell M">M. O’Donnell</name></author><author><name sortKey="O Anlon, S" uniqKey="O Anlon S">S. O’Hanlon</name></author><author><name sortKey="Olives, C" uniqKey="Olives C">C. Olives</name></author><author><name sortKey="Omer, S B" uniqKey="Omer S">S.B. Omer</name></author><author><name sortKey="Ortblad, K" uniqKey="Ortblad K">K. Ortblad</name></author><author><name sortKey="Osborne, R" uniqKey="Osborne R">R. Osborne</name></author><author><name sortKey="Ozgediz, D" uniqKey="Ozgediz D">D. Ozgediz</name></author><author><name sortKey="Page, A" uniqKey="Page A">A. Page</name></author><author><name sortKey="Pahari, B" uniqKey="Pahari B">B. Pahari</name></author><author><name sortKey="Pandian, J D" uniqKey="Pandian J">J.D. Pandian</name></author><author><name sortKey="Rivero, A P" uniqKey="Rivero A">A.P. Rivero</name></author><author><name sortKey="Patten, S B" uniqKey="Patten S">S.B. Patten</name></author><author><name sortKey="Pearce, N" uniqKey="Pearce N">N. Pearce</name></author><author><name sortKey="Padilla, R P" uniqKey="Padilla R">R.P. Padilla</name></author><author><name sortKey="Perez Ruiz, F" uniqKey="Perez Ruiz F">F. Perez-Ruiz</name></author><author><name sortKey="Perico, N" uniqKey="Perico N">N. Perico</name></author><author><name sortKey="Pesudovs, K" uniqKey="Pesudovs K">K. Pesudovs</name></author><author><name sortKey="Phillips, D" uniqKey="Phillips D">D. Phillips</name></author><author><name sortKey="Phillips, M R" uniqKey="Phillips M">M.R. Phillips</name></author><author><name sortKey="Pierce, K" uniqKey="Pierce K">K. Pierce</name></author><author><name sortKey="Pion, S" uniqKey="Pion S">S. Pion</name></author><author><name sortKey="Polanczyk, G V" uniqKey="Polanczyk G">G.V. Polanczyk</name></author><author><name sortKey="Polinder, S" uniqKey="Polinder S">S. Polinder</name></author><author><name sortKey="Pope, C A" uniqKey="Pope C">C.A. Pope</name></author><author><name sortKey="Popova, S" uniqKey="Popova S">S. Popova</name></author><author><name sortKey="Porrini, E" uniqKey="Porrini E">E. Porrini</name></author><author><name sortKey="Pourmalek, F" uniqKey="Pourmalek F">F. Pourmalek</name></author><author><name sortKey="Prince, M" uniqKey="Prince M">M. Prince</name></author><author><name sortKey="Pullan, R L" uniqKey="Pullan R">R.L. Pullan</name></author><author><name sortKey="Ramaiah, K D" uniqKey="Ramaiah K">K.D. Ramaiah</name></author><author><name sortKey="Ranganathan, D" uniqKey="Ranganathan D">D. Ranganathan</name></author><author><name sortKey="Razavi, H" uniqKey="Razavi H">H. Razavi</name></author><author><name sortKey="Regan, M" uniqKey="Regan M">M. Regan</name></author><author><name sortKey="Rehm, J T" uniqKey="Rehm J">J.T. Rehm</name></author><author><name sortKey="Rein, D B" uniqKey="Rein D">D.B. Rein</name></author><author><name sortKey="Remuzzi, G" uniqKey="Remuzzi G">G. Remuzzi</name></author><author><name sortKey="Richardson, K" uniqKey="Richardson K">K. Richardson</name></author><author><name sortKey="Rivara, F P" uniqKey="Rivara F">F.P. Rivara</name></author><author><name sortKey="Roberts, T" uniqKey="Roberts T">T. Roberts</name></author><author><name sortKey="Robinson, C" uniqKey="Robinson C">C. Robinson</name></author><author><name sortKey="De Leon, F R" uniqKey="De Leon F">F.R. De Leon</name></author><author><name sortKey="Ronfani, L" uniqKey="Ronfani L">L. Ronfani</name></author><author><name sortKey="Room, R" uniqKey="Room R">R. Room</name></author><author><name sortKey="Rosenfeld, L C" uniqKey="Rosenfeld L">L.C. Rosenfeld</name></author><author><name sortKey="Rushton, L" uniqKey="Rushton L">L. Rushton</name></author><author><name sortKey="Sacco, R L" uniqKey="Sacco R">R.L. Sacco</name></author><author><name sortKey="Saha, S" uniqKey="Saha S">S. Saha</name></author><author><name sortKey="Sampson, U" uniqKey="Sampson U">U. Sampson</name></author><author><name sortKey="Sanchez Riera, L" uniqKey="Sanchez Riera L">L. Sanchez-Riera</name></author><author><name sortKey="Sanman, E" uniqKey="Sanman E">E. Sanman</name></author><author><name sortKey="Schwebel, D C" uniqKey="Schwebel D">D.C. Schwebel</name></author><author><name sortKey="Scott, J G" uniqKey="Scott J">J.G. Scott</name></author><author><name sortKey="Segui Gomez, M" uniqKey="Segui Gomez M">M. Segui-Gomez</name></author><author><name sortKey="Shahraz, S" uniqKey="Shahraz S">S. Shahraz</name></author><author><name sortKey="Shepard, D S" uniqKey="Shepard D">D.S. Shepard</name></author><author><name sortKey="Shin, H" uniqKey="Shin H">H. Shin</name></author><author><name sortKey="Shivakoti, R" uniqKey="Shivakoti R">R. Shivakoti</name></author><author><name sortKey="Singh, D" uniqKey="Singh D">D. Singh</name></author><author><name sortKey="Singh, G M" uniqKey="Singh G">G.M. Singh</name></author><author><name sortKey="Singh, J A" uniqKey="Singh J">J.A. Singh</name></author><author><name sortKey="Singleton, J" uniqKey="Singleton J">J. Singleton</name></author><author><name sortKey="Sleet, D A" uniqKey="Sleet D">D.A. Sleet</name></author><author><name sortKey="Sliwa, K" uniqKey="Sliwa K">K. Sliwa</name></author><author><name sortKey="Smith, E" uniqKey="Smith E">E. Smith</name></author><author><name sortKey="Smith, J L" uniqKey="Smith J">J.L. Smith</name></author><author><name sortKey="Stapelberg, N J" uniqKey="Stapelberg N">N.J. Stapelberg</name></author><author><name sortKey="Steer, A" uniqKey="Steer A">A. Steer</name></author><author><name sortKey="Steiner, T" uniqKey="Steiner T">T. Steiner</name></author><author><name sortKey="Stolk, W A" uniqKey="Stolk W">W.A. Stolk</name></author><author><name sortKey="Stovner, L J" uniqKey="Stovner L">L.J. Stovner</name></author><author><name sortKey="Sudfeld, C" uniqKey="Sudfeld C">C. Sudfeld</name></author><author><name sortKey="Syed, S" uniqKey="Syed S">S. Syed</name></author><author><name sortKey="Tamburlini, G" uniqKey="Tamburlini G">G. Tamburlini</name></author><author><name sortKey="Tavakkoli, M" uniqKey="Tavakkoli M">M. Tavakkoli</name></author><author><name sortKey="Taylor, H R" uniqKey="Taylor H">H.R. Taylor</name></author><author><name sortKey="Taylor, J A" uniqKey="Taylor J">J.A. Taylor</name></author><author><name sortKey="Taylor, W J" uniqKey="Taylor W">W.J. Taylor</name></author><author><name sortKey="Thomas, B" uniqKey="Thomas B">B. Thomas</name></author><author><name sortKey="Thomson, W M" uniqKey="Thomson W">W.M. Thomson</name></author><author><name sortKey="Thurston, G D" uniqKey="Thurston G">G.D. Thurston</name></author><author><name sortKey="Tleyjeh, I M" uniqKey="Tleyjeh I">I.M. Tleyjeh</name></author><author><name sortKey="Tonelli, M" uniqKey="Tonelli M">M. Tonelli</name></author><author><name sortKey="Towbin, J A" uniqKey="Towbin J">J.A. Towbin</name></author><author><name sortKey="Truelsen, T" uniqKey="Truelsen T">T. Truelsen</name></author><author><name sortKey="Tsilimbaris, M K" uniqKey="Tsilimbaris M">M.K. Tsilimbaris</name></author><author><name sortKey="Ubeda, C" uniqKey="Ubeda C">C. Ubeda</name></author><author><name sortKey="Undurraga, E A" uniqKey="Undurraga E">E.A. Undurraga</name></author><author><name sortKey="Van Der Werf, M J" uniqKey="Van Der Werf M">M.J. van der Werf</name></author><author><name sortKey="Van Os, J" uniqKey="Van Os J">J. van Os</name></author><author><name sortKey="Vavilala, M S" uniqKey="Vavilala M">M.S. Vavilala</name></author><author><name sortKey="Venketasubramanian, N" uniqKey="Venketasubramanian N">N. Venketasubramanian</name></author><author><name sortKey="Wang, M" uniqKey="Wang M">M. Wang</name></author><author><name sortKey="Wang, W" uniqKey="Wang W">W. Wang</name></author><author><name sortKey="Watt, K" uniqKey="Watt K">K. Watt</name></author><author><name sortKey="Weatherall, D J" uniqKey="Weatherall D">D.J. Weatherall</name></author><author><name sortKey="Weinstock, M A" uniqKey="Weinstock M">M.A. Weinstock</name></author><author><name sortKey="Weintraub, R" uniqKey="Weintraub R">R. Weintraub</name></author><author><name sortKey="Weisskopf, M G" uniqKey="Weisskopf M">M.G. Weisskopf</name></author><author><name sortKey="Weissman, M M" uniqKey="Weissman M">M.M. Weissman</name></author><author><name sortKey="White, R A" uniqKey="White R">R.A. White</name></author><author><name sortKey="Whiteford, H" uniqKey="Whiteford H">H. Whiteford</name></author><author><name sortKey="Wiebe, N" uniqKey="Wiebe N">N. Wiebe</name></author><author><name sortKey="Wiersma, S T" uniqKey="Wiersma S">S.T. Wiersma</name></author><author><name sortKey="Wilkinson, J D" uniqKey="Wilkinson J">J.D. Wilkinson</name></author><author><name sortKey="Williams, H C" uniqKey="Williams H">H.C. Williams</name></author><author><name sortKey="Williams, S R" uniqKey="Williams S">S.R. Williams</name></author><author><name sortKey="Witt, E" uniqKey="Witt E">E. Witt</name></author><author><name sortKey="Wolfe, F" uniqKey="Wolfe F">F. Wolfe</name></author><author><name sortKey="Woolf, A D" uniqKey="Woolf A">A.D. Woolf</name></author><author><name sortKey="Wulf, S" uniqKey="Wulf S">S. Wulf</name></author><author><name sortKey="Yeh, P H" uniqKey="Yeh P">P.H. Yeh</name></author><author><name sortKey="Zaidi, A K" uniqKey="Zaidi A">A.K. Zaidi</name></author><author><name sortKey="Zheng, Z J" uniqKey="Zheng Z">Z.J. Zheng</name></author><author><name sortKey="Zonies, D" uniqKey="Zonies D">D. Zonies</name></author><author><name sortKey="Lopez, A D" uniqKey="Lopez A">A.D. Lopez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Musgrave, I A" uniqKey="Musgrave I">I.A. Musgrave</name></author><author><name sortKey="Hawes, R B" uniqKey="Hawes R">R.B. Hawes</name></author><author><name sortKey="Jameson, J L" uniqKey="Jameson J">J.L. Jameson</name></author><author><name sortKey="Sloane, R A" uniqKey="Sloane R">R.A. Sloane</name></author><author><name sortKey="Quayle, P A" uniqKey="Quayle P">P.A. Quayle</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nfon, C K" uniqKey="Nfon C">C.K. Nfon</name></author><author><name sortKey="Makepeace, B L" uniqKey="Makepeace B">B.L. Makepeace</name></author><author><name sortKey="Njongmeta, L M" uniqKey="Njongmeta L">L.M. Njongmeta</name></author><author><name sortKey="Tanya, V N" uniqKey="Tanya V">V.N. Tanya</name></author><author><name sortKey="Trees, A J" uniqKey="Trees A">A.J. Trees</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="N Oran, E K" uniqKey="N Oran E">E.K. N’Goran</name></author><author><name sortKey="Utzinger, J" uniqKey="Utzinger J">J. Utzinger</name></author><author><name sortKey="Gnaka, H N" uniqKey="Gnaka H">H.N. Gnaka</name></author><author><name sortKey="Yapi, A" uniqKey="Yapi A">A. Yapi</name></author><author><name sortKey="N Uessan, N A" uniqKey="N Uessan N">N.A. N’Guessan</name></author><author><name sortKey="Kigbafori, S D" uniqKey="Kigbafori S">S.D. Kigbafori</name></author><author><name sortKey="Lengeler, C" uniqKey="Lengeler C">C. Lengeler</name></author><author><name sortKey="Chollet, J" uniqKey="Chollet J">J. Chollet</name></author><author><name sortKey="Shuhua, X" uniqKey="Shuhua X">X. Shuhua</name></author><author><name sortKey="Tanner, M" uniqKey="Tanner M">M. Tanner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="O Onnor, K A" uniqKey="O Onnor K">K.A. O’Connor</name></author><author><name sortKey="Roth, B L" uniqKey="Roth B">B.L. Roth</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Olliaro, P" uniqKey="Olliaro P">P. Olliaro</name></author><author><name sortKey="Seiler, J" uniqKey="Seiler J">J. Seiler</name></author><author><name sortKey="Kuesel, A" uniqKey="Kuesel A">A. Kuesel</name></author><author><name sortKey="Horton, J" uniqKey="Horton J">J. Horton</name></author><author><name sortKey="Clark, J N" uniqKey="Clark J">J.N. Clark</name></author><author><name sortKey="Don, R" uniqKey="Don R">R. Don</name></author><author><name sortKey="Keiser, J" uniqKey="Keiser J">J. Keiser</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ortiz, P" uniqKey="Ortiz P">P. Ortiz</name></author><author><name sortKey="Terrones, S" uniqKey="Terrones S">S. Terrones</name></author><author><name sortKey="Cabrera, M" uniqKey="Cabrera M">M. Cabrera</name></author><author><name sortKey="Hoban, C" uniqKey="Hoban C">C. Hoban</name></author><author><name sortKey="Ceballos, L" uniqKey="Ceballos L">L. Ceballos</name></author><author><name sortKey="Moreno, L" uniqKey="Moreno L">L. Moreno</name></author><author><name sortKey="Canton, C" uniqKey="Canton C">C. Canton</name></author><author><name sortKey="Donadeu, M" uniqKey="Donadeu M">M. Donadeu</name></author><author><name sortKey="Lanusse, C" uniqKey="Lanusse C">C. Lanusse</name></author><author><name sortKey="Alvarez, L" uniqKey="Alvarez L">L. Alvarez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Padhy, B M" uniqKey="Padhy B">B.M. Padhy</name></author><author><name sortKey="Gupta, Y K" uniqKey="Gupta Y">Y.K. Gupta</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Pearson, R D" uniqKey="Pearson R">R.D. Pearson</name></author><author><name sortKey="Hewlett, E L" uniqKey="Hewlett E">E.L. Hewlett</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pedrique, B" uniqKey="Pedrique B">B. Pedrique</name></author><author><name sortKey="Strub Wourgaft, N" uniqKey="Strub Wourgaft N">N. Strub-Wourgaft</name></author><author><name sortKey="Some, C" uniqKey="Some C">C. Some</name></author><author><name sortKey="Olliaro, P" uniqKey="Olliaro P">P. Olliaro</name></author><author><name sortKey="Trouiller, P" uniqKey="Trouiller P">P. Trouiller</name></author><author><name sortKey="Ford, N" uniqKey="Ford N">N. Ford</name></author><author><name sortKey="Pecoul, B" uniqKey="Pecoul B">B. Pécoul</name></author><author><name sortKey="Bradol, J H" uniqKey="Bradol J">J.-H. Bradol</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Perez Molina, J A" uniqKey="Perez Molina J">J.A. Perez-Molina</name></author><author><name sortKey="Diaz Menendez, M" uniqKey="Diaz Menendez M">M. Diaz-Menendez</name></author><author><name sortKey="Gallego, J I" uniqKey="Gallego J">J.I. Gallego</name></author><author><name sortKey="Norman, F" uniqKey="Norman F">F. Norman</name></author><author><name sortKey="Monge Maillo, B" uniqKey="Monge Maillo B">B. Monge-Maillo</name></author><author><name sortKey="Ayala, A P" uniqKey="Ayala A">A.P. Ayala</name></author><author><name sortKey="Lopez Velez, R" uniqKey="Lopez Velez R">R. Lopez-Velez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Perez Del Villar, L" uniqKey="Perez Del Villar L">L. Perez del Villar</name></author><author><name sortKey="Burguillo, F J" uniqKey="Burguillo F">F.J. Burguillo</name></author><author><name sortKey="Lopez Aban, J" uniqKey="Lopez Aban J">J. Lopez-Aban</name></author><author><name sortKey="Muro, A" uniqKey="Muro A">A. Muro</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Qian, M B" uniqKey="Qian M">M.B. Qian</name></author><author><name sortKey="Yap, P" uniqKey="Yap P">P. Yap</name></author><author><name sortKey="Yang, Y C" uniqKey="Yang Y">Y.C. Yang</name></author><author><name sortKey="Liang, H" uniqKey="Liang H">H. Liang</name></author><author><name sortKey="Jiang, Z H" uniqKey="Jiang Z">Z.H. Jiang</name></author><author><name sortKey="Li, W" uniqKey="Li W">W. Li</name></author><author><name sortKey="Tan, Y G" uniqKey="Tan Y">Y.G. Tan</name></author><author><name sortKey="Zhou, H" uniqKey="Zhou H">H. Zhou</name></author><author><name sortKey="Utzinger, J" uniqKey="Utzinger J">J. Utzinger</name></author><author><name sortKey="Zhou, X N" uniqKey="Zhou X">X.N. Zhou</name></author><author><name sortKey="Keiser, J" uniqKey="Keiser J">J. Keiser</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ranjan, S" uniqKey="Ranjan S">S. Ranjan</name></author><author><name sortKey="Delay, R" uniqKey="Delay R">R. DeLay</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rao, R U" uniqKey="Rao R">R.U. Rao</name></author><author><name sortKey="Huang, Y" uniqKey="Huang Y">Y. Huang</name></author><author><name sortKey="Fischer, K" uniqKey="Fischer K">K. Fischer</name></author><author><name sortKey="Fischer, P U" uniqKey="Fischer P">P.U. Fischer</name></author><author><name sortKey="Weil, G J" uniqKey="Weil G">G.J. Weil</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reichard, M V" uniqKey="Reichard M">M.V. Reichard</name></author><author><name sortKey="Wolf, R F" uniqKey="Wolf R">R.F. Wolf</name></author><author><name sortKey="Carey, D W" uniqKey="Carey D">D.W. Carey</name></author><author><name sortKey="Garrett, J J" uniqKey="Garrett J">J.J. Garrett</name></author><author><name sortKey="Briscoe, H A" uniqKey="Briscoe H">H.A. Briscoe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reinemeyer, C R" uniqKey="Reinemeyer C">C.R. Reinemeyer</name></author><author><name sortKey="Cleale, R M" uniqKey="Cleale R">R.M. Cleale</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reuter, S" uniqKey="Reuter S">S. Reuter</name></author><author><name sortKey="Buck, A" uniqKey="Buck A">A. Buck</name></author><author><name sortKey="Grebe, O" uniqKey="Grebe O">O. Grebe</name></author><author><name sortKey="Nussle Kugele, K" uniqKey="Nussle Kugele K">K. Nussle-Kugele</name></author><author><name sortKey="Kern, P" uniqKey="Kern P">P. Kern</name></author><author><name sortKey="Manfras, B J" uniqKey="Manfras B">B.J. Manfras</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reuter, S" uniqKey="Reuter S">S. Reuter</name></author><author><name sortKey="Merkle, M" uniqKey="Merkle M">M. Merkle</name></author><author><name sortKey="Brehm, K" uniqKey="Brehm K">K. Brehm</name></author><author><name sortKey="Kern, P" uniqKey="Kern P">P. Kern</name></author><author><name sortKey="Manfras, B" uniqKey="Manfras B">B. Manfras</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reuter, S" uniqKey="Reuter S">S. Reuter</name></author><author><name sortKey="Manfras, B" uniqKey="Manfras B">B. Manfras</name></author><author><name sortKey="Merkle, M" uniqKey="Merkle M">M. Merkle</name></author><author><name sortKey="Harter, G" uniqKey="Harter G">G. Harter</name></author><author><name sortKey="Kern, P" uniqKey="Kern P">P. Kern</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Richards, F O" uniqKey="Richards F">F.O. Richards</name></author><author><name sortKey="Amann, J" uniqKey="Amann J">J. Amann</name></author><author><name sortKey="Arana, B" uniqKey="Arana B">B. Arana</name></author><author><name sortKey="Punkosdy, G" uniqKey="Punkosdy G">G. Punkosdy</name></author><author><name sortKey="Klein, R" uniqKey="Klein R">R. Klein</name></author><author><name sortKey="Blanco, C" uniqKey="Blanco C">C. Blanco</name></author><author><name sortKey="Lopez, B" uniqKey="Lopez B">B. Lopez</name></author><author><name sortKey="Mendoza, C" uniqKey="Mendoza C">C. Mendoza</name></author><author><name sortKey="Dominguez, A" uniqKey="Dominguez A">A. Dominguez</name></author><author><name sortKey="Guarner, J" uniqKey="Guarner J">J. Guarner</name></author><author><name sortKey="Maguire, J H" uniqKey="Maguire J">J.H. Maguire</name></author><author><name sortKey="Eberhard, M" uniqKey="Eberhard M">M. Eberhard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Richter, D" uniqKey="Richter D">D. Richter</name></author><author><name sortKey="Richter, J" uniqKey="Richter J">J. Richter</name></author><author><name sortKey="Gruner, B" uniqKey="Gruner B">B. Gruner</name></author><author><name sortKey="Kranz, K" uniqKey="Kranz K">K. Kranz</name></author><author><name sortKey="Franz, J" uniqKey="Franz J">J. Franz</name></author><author><name sortKey="Kern, P" uniqKey="Kern P">P. Kern</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rim, H J" uniqKey="Rim H">H.J. Rim</name></author><author><name sortKey="Lee, J S" uniqKey="Lee J">J.S. Lee</name></author><author><name sortKey="Joo, K H" uniqKey="Joo K">K.H. Joo</name></author><author><name sortKey="Kim, Y S" uniqKey="Kim Y">Y.S. Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Romero Cabello, R" uniqKey="Romero Cabello R">R. Romero Cabello</name></author><author><name sortKey="Guerrero, L R" uniqKey="Guerrero L">L.R. Guerrero</name></author><author><name sortKey="Munoz Garcia, M R" uniqKey="Munoz Garcia M">M.R. Munoz Garcia</name></author><author><name sortKey="Geyne Cruz, A" uniqKey="Geyne Cruz A">A. Geyne Cruz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rossignol, J F" uniqKey="Rossignol J">J.F. Rossignol</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rossignol, J F" uniqKey="Rossignol J">J.F. Rossignol</name></author><author><name sortKey="Maisonneuve, H" uniqKey="Maisonneuve H">H. Maisonneuve</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Saeki, H" uniqKey="Saeki H">H. Saeki</name></author><author><name sortKey="Ishii, T" uniqKey="Ishii T">T. Ishii</name></author><author><name sortKey="Ohta, M" uniqKey="Ohta M">M. Ohta</name></author><author><name sortKey="Tsuchiya, S" uniqKey="Tsuchiya S">S. Tsuchiya</name></author><author><name sortKey="Furuya, T" uniqKey="Furuya T">T. Furuya</name></author><author><name sortKey="Fujii, T" uniqKey="Fujii T">T. Fujii</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Salem, H H" uniqKey="Salem H">H.H. Salem</name></author><author><name sortKey="El Allaf, G" uniqKey="El Allaf G">G. el-Allaf</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sanchez Carrillo, M C" uniqKey="Sanchez Carrillo M">M.C. Sanchez-Carrillo</name></author><author><name sortKey="Beltran Hernandez, F" uniqKey="Beltran Hernandez F">F. Beltran-Hernandez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schad, G A" uniqKey="Schad G">G.A. Schad</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sekhon, B S" uniqKey="Sekhon B">B.S. Sekhon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shikiya, K" uniqKey="Shikiya K">K. Shikiya</name></author><author><name sortKey="Kuniyoshi, T" uniqKey="Kuniyoshi T">T. Kuniyoshi</name></author><author><name sortKey="Higashionna, A" uniqKey="Higashionna A">A. Higashionna</name></author><author><name sortKey="Arakkaki, T" uniqKey="Arakkaki T">T. Arakkaki</name></author><author><name sortKey="Oyakawa, T" uniqKey="Oyakawa T">T. Oyakawa</name></author><author><name sortKey="Kadena, K" uniqKey="Kadena K">K. Kadena</name></author><author><name sortKey="Kinjo, F" uniqKey="Kinjo F">F. Kinjo</name></author><author><name sortKey="Saito, A" uniqKey="Saito A">A. Saito</name></author><author><name sortKey="Asato, R" uniqKey="Asato R">R. Asato</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shikiya, K" uniqKey="Shikiya K">K. Shikiya</name></author><author><name sortKey="Kinjo, N" uniqKey="Kinjo N">N. Kinjo</name></author><author><name sortKey="Ikema, M" uniqKey="Ikema M">M. Ikema</name></author><author><name sortKey="Yamashiro, A" uniqKey="Yamashiro A">A. Yamashiro</name></author><author><name sortKey="Uechi, H" uniqKey="Uechi H">H. Uechi</name></author><author><name sortKey="Oyakawa, T" uniqKey="Oyakawa T">T. Oyakawa</name></author><author><name sortKey="Kinjo, F" uniqKey="Kinjo F">F. Kinjo</name></author><author><name sortKey="Saito, A" uniqKey="Saito A">A. Saito</name></author><author><name sortKey="Nakamura, H" uniqKey="Nakamura H">H. Nakamura</name></author><author><name sortKey="Ohwan, T" uniqKey="Ohwan T">T. Ohwan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Soo, G W" uniqKey="Soo G">G.W. Soo</name></author><author><name sortKey="Law, J H" uniqKey="Law J">J.H. Law</name></author><author><name sortKey="Kan, E" uniqKey="Kan E">E. Kan</name></author><author><name sortKey="Tan, S Y" uniqKey="Tan S">S.Y. Tan</name></author><author><name sortKey="Lim, W Y" uniqKey="Lim W">W.Y. Lim</name></author><author><name sortKey="Chay, G" uniqKey="Chay G">G. Chay</name></author><author><name sortKey="Bukhari, N I" uniqKey="Bukhari N">N.I. Bukhari</name></author><author><name sortKey="Segarra, I" uniqKey="Segarra I">I. Segarra</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sotelo, J" uniqKey="Sotelo J">J. Sotelo</name></author><author><name sortKey="Escobedo, F" uniqKey="Escobedo F">F. Escobedo</name></author><author><name sortKey="Penagos, P" uniqKey="Penagos P">P. Penagos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sotelo, J" uniqKey="Sotelo J">J. Sotelo</name></author><author><name sortKey="Del Brutto, O H" uniqKey="Del Brutto O">O.H. del Brutto</name></author><author><name sortKey="Penagos, P" uniqKey="Penagos P">P. Penagos</name></author><author><name sortKey="Escobedo, F" uniqKey="Escobedo F">F. Escobedo</name></author><author><name sortKey="Torres, B" uniqKey="Torres B">B. Torres</name></author><author><name sortKey="Rodriguez Carbajal, J" uniqKey="Rodriguez Carbajal J">J. Rodriguez-Carbajal</name></author><author><name sortKey="Rubio Donnadieu, F" uniqKey="Rubio Donnadieu F">F. Rubio-Donnadieu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Soukhathammavong, P" uniqKey="Soukhathammavong P">P. Soukhathammavong</name></author><author><name sortKey="Odermatt, P" uniqKey="Odermatt P">P. Odermatt</name></author><author><name sortKey="Sayasone, S" uniqKey="Sayasone S">S. Sayasone</name></author><author><name sortKey="Vonghachack, Y" uniqKey="Vonghachack Y">Y. Vonghachack</name></author><author><name sortKey="Vounatsou, P" uniqKey="Vounatsou P">P. Vounatsou</name></author><author><name sortKey="Hatz, C" uniqKey="Hatz C">C. Hatz</name></author><author><name sortKey="Akkhavong, K" uniqKey="Akkhavong K">K. Akkhavong</name></author><author><name sortKey="Keiser, J" uniqKey="Keiser J">J. Keiser</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Specht, S" uniqKey="Specht S">S. Specht</name></author><author><name sortKey="Mand, S" uniqKey="Mand S">S. Mand</name></author><author><name sortKey="Marfo Debrekyei, Y" uniqKey="Marfo Debrekyei Y">Y. Marfo-Debrekyei</name></author><author><name sortKey="Debrah, A Y" uniqKey="Debrah A">A.Y. Debrah</name></author><author><name sortKey="Konadu, P" uniqKey="Konadu P">P. Konadu</name></author><author><name sortKey="Adjei, O" uniqKey="Adjei O">O. Adjei</name></author><author><name sortKey="Buttner, D W" uniqKey="Buttner D">D.W. Buttner</name></author><author><name sortKey="Hoerauf, A" uniqKey="Hoerauf A">A. Hoerauf</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Speich, B" uniqKey="Speich B">B. Speich</name></author><author><name sortKey="Ame, S M" uniqKey="Ame S">S.M. Ame</name></author><author><name sortKey="Ali, S M" uniqKey="Ali S">S.M. Ali</name></author><author><name sortKey="Alles, R" uniqKey="Alles R">R. Alles</name></author><author><name sortKey="Hattendorf, J" uniqKey="Hattendorf J">J. Hattendorf</name></author><author><name sortKey="Utzinger, J R" uniqKey="Utzinger J">J.R. Utzinger</name></author><author><name sortKey="Albonico, M" uniqKey="Albonico M">M. Albonico</name></author><author><name sortKey="Keiser, J" uniqKey="Keiser J">J. Keiser</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Speich, B" uniqKey="Speich B">B. Speich</name></author><author><name sortKey="Marti, H" uniqKey="Marti H">H. Marti</name></author><author><name sortKey="Ame, S M" uniqKey="Ame S">S.M. Ame</name></author><author><name sortKey="Ali, S M" uniqKey="Ali S">S.M. Ali</name></author><author><name sortKey="Bogoch, I I" uniqKey="Bogoch I">I.I. Bogoch</name></author><author><name sortKey="Utzinger, J" uniqKey="Utzinger J">J. Utzinger</name></author><author><name sortKey="Albonico, M" uniqKey="Albonico M">M. Albonico</name></author><author><name sortKey="Keiser, J" uniqKey="Keiser J">J. Keiser</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Speich, B" uniqKey="Speich B">B. Speich</name></author><author><name sortKey="Ame, S M" uniqKey="Ame S">S.M. Ame</name></author><author><name sortKey="Ali, S M" uniqKey="Ali S">S.M. Ali</name></author><author><name sortKey="Alles, R" uniqKey="Alles R">R. Alles</name></author><author><name sortKey="Huwyler, J" uniqKey="Huwyler J">J. Huwyler</name></author><author><name sortKey="Hattendorf, J" uniqKey="Hattendorf J">J. Hattendorf</name></author><author><name sortKey="Utzinger, J" uniqKey="Utzinger J">J. Utzinger</name></author><author><name sortKey="Albonico, M" uniqKey="Albonico M">M. Albonico</name></author><author><name sortKey="Keiser, J" uniqKey="Keiser J">J. Keiser</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Spicher, M" uniqKey="Spicher M">M. Spicher</name></author><author><name sortKey="Roethlisberger, C" uniqKey="Roethlisberger C">C. Roethlisberger</name></author><author><name sortKey="Lany, C" uniqKey="Lany C">C. Lany</name></author><author><name sortKey="Stadelmann, B" uniqKey="Stadelmann B">B. Stadelmann</name></author><author><name sortKey="Keiser, J" uniqKey="Keiser J">J. Keiser</name></author><author><name sortKey="Ortega Mora, L M" uniqKey="Ortega Mora L">L.M. Ortega-Mora</name></author><author><name sortKey="Gottstein, B" uniqKey="Gottstein B">B. Gottstein</name></author><author><name sortKey="Hemphill, A" uniqKey="Hemphill A">A. Hemphill</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Steinmann, P" uniqKey="Steinmann P">P. Steinmann</name></author><author><name sortKey="Zhou, X N" uniqKey="Zhou X">X.N. Zhou</name></author><author><name sortKey="Du, Z W" uniqKey="Du Z">Z.W. Du</name></author><author><name sortKey="Jiang, J Y" uniqKey="Jiang J">J.Y. Jiang</name></author><author><name sortKey="Xiao, S H" uniqKey="Xiao S">S.H. Xiao</name></author><author><name sortKey="Wu, Z X" uniqKey="Wu Z">Z.X. Wu</name></author><author><name sortKey="Zhou, H" uniqKey="Zhou H">H. Zhou</name></author><author><name sortKey="Utzinger, J" uniqKey="Utzinger J">J. Utzinger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stettler, M" uniqKey="Stettler M">M. Stettler</name></author><author><name sortKey="Fink, R" uniqKey="Fink R">R. Fink</name></author><author><name sortKey="Walker, M" uniqKey="Walker M">M. Walker</name></author><author><name sortKey="Gottstein, B" uniqKey="Gottstein B">B. Gottstein</name></author><author><name sortKey="Geary, T G" uniqKey="Geary T">T.G. Geary</name></author><author><name sortKey="Rossignol, J F" uniqKey="Rossignol J">J.F. Rossignol</name></author><author><name sortKey="Hemphill, A" uniqKey="Hemphill A">A. Hemphill</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stettler, M" uniqKey="Stettler M">M. Stettler</name></author><author><name sortKey="Rossignol, J F" uniqKey="Rossignol J">J.F. Rossignol</name></author><author><name sortKey="Fink, R" uniqKey="Fink R">R. Fink</name></author><author><name sortKey="Walker, M" uniqKey="Walker M">M. Walker</name></author><author><name sortKey="Gottstein, B" uniqKey="Gottstein B">B. Gottstein</name></author><author><name sortKey="Merli, M" uniqKey="Merli M">M. Merli</name></author><author><name sortKey="Theurillat, R" uniqKey="Theurillat R">R. Theurillat</name></author><author><name sortKey="Thormann, W" uniqKey="Thormann W">W. Thormann</name></author><author><name sortKey="Dricot, E" uniqKey="Dricot E">E. Dricot</name></author><author><name sortKey="Segers, R" uniqKey="Segers R">R. Segers</name></author><author><name sortKey="Hemphill, A" uniqKey="Hemphill A">A. Hemphill</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stewart, T B" uniqKey="Stewart T">T.B. Stewart</name></author><author><name sortKey="Fox, M C" uniqKey="Fox M">M.C. Fox</name></author><author><name sortKey="Wiles, S E" uniqKey="Wiles S">S.E. Wiles</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stewart, T B" uniqKey="Stewart T">T.B. Stewart</name></author><author><name sortKey="Wiles, S E" uniqKey="Wiles S">S.E. Wiles</name></author><author><name sortKey="Miller, J E" uniqKey="Miller J">J.E. Miller</name></author><author><name sortKey="Rulli, R D" uniqKey="Rulli R">R.D. Rulli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stothard, J R" uniqKey="Stothard J">J.R. Stothard</name></author><author><name sortKey="Sousa Figueiredo, J C" uniqKey="Sousa Figueiredo J">J.C. Sousa-Figueiredo</name></author><author><name sortKey="Betson, M" uniqKey="Betson M">M. Betson</name></author><author><name sortKey="Bustinduy, A" uniqKey="Bustinduy A">A. Bustinduy</name></author><author><name sortKey="Reinhard Rupp, J" uniqKey="Reinhard Rupp J">J. Reinhard-Rupp</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Supali, T" uniqKey="Supali T">T. Supali</name></author><author><name sortKey="Djuardi, Y" uniqKey="Djuardi Y">Y. Djuardi</name></author><author><name sortKey="Pfarr, K M" uniqKey="Pfarr K">K.M. Pfarr</name></author><author><name sortKey="Wibowo, H" uniqKey="Wibowo H">H. Wibowo</name></author><author><name sortKey="Taylor, M J" uniqKey="Taylor M">M.J. Taylor</name></author><author><name sortKey="Hoerauf, A" uniqKey="Hoerauf A">A. Hoerauf</name></author><author><name sortKey="Houwing Duistermaat, J J" uniqKey="Houwing Duistermaat J">J.J. Houwing-Duistermaat</name></author><author><name sortKey="Yazdanbakhsh, M" uniqKey="Yazdanbakhsh M">M. Yazdanbakhsh</name></author><author><name sortKey="Sartono, E" uniqKey="Sartono E">E. Sartono</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Takayanagui, O M" uniqKey="Takayanagui O">O.M. Takayanagui</name></author><author><name sortKey="Jardim, E" uniqKey="Jardim E">E. Jardim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Taylor, M J" uniqKey="Taylor M">M.J. Taylor</name></author><author><name sortKey="Makunde, W H" uniqKey="Makunde W">W.H. Makunde</name></author><author><name sortKey="Mcgarry, H F" uniqKey="Mcgarry H">H.F. McGarry</name></author><author><name sortKey="Turner, J D" uniqKey="Turner J">J.D. Turner</name></author><author><name sortKey="Mand, S" uniqKey="Mand S">S. Mand</name></author><author><name sortKey="Hoerauf, A" uniqKey="Hoerauf A">A. Hoerauf</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Taylor, M J" uniqKey="Taylor M">M.J. Taylor</name></author><author><name sortKey="Awadzi, K" uniqKey="Awadzi K">K. Awadzi</name></author><author><name sortKey="Basanez, M G" uniqKey="Basanez M">M.G. Basanez</name></author><author><name sortKey="Biritwum, N" uniqKey="Biritwum N">N. Biritwum</name></author><author><name sortKey="Boakye, D" uniqKey="Boakye D">D. Boakye</name></author><author><name sortKey="Boatin, B" uniqKey="Boatin B">B. Boatin</name></author><author><name sortKey="Bockarie, M" uniqKey="Bockarie M">M. Bockarie</name></author><author><name sortKey="Churcher, T S" uniqKey="Churcher T">T.S. Churcher</name></author><author><name sortKey="Debrah, A" uniqKey="Debrah A">A. Debrah</name></author><author><name sortKey="Edwards, G" uniqKey="Edwards G">G. Edwards</name></author><author><name sortKey="Hoerauf, A" uniqKey="Hoerauf A">A. Hoerauf</name></author><author><name sortKey="Mand, S" uniqKey="Mand S">S. Mand</name></author><author><name sortKey="Matthews, G" uniqKey="Matthews G">G. Matthews</name></author><author><name sortKey="Osei Atweneboana, M" uniqKey="Osei Atweneboana M">M. Osei-Atweneboana</name></author><author><name sortKey="Prichard, R K" uniqKey="Prichard R">R.K. Prichard</name></author><author><name sortKey="Wanji, S" uniqKey="Wanji S">S. Wanji</name></author><author><name sortKey="Adjei, O" uniqKey="Adjei O">O. Adjei</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Terrazas, L I" uniqKey="Terrazas L">L.I. Terrazas</name></author><author><name sortKey="Bojalil, R" uniqKey="Bojalil R">R. Bojalil</name></author><author><name sortKey="Govezensky, T" uniqKey="Govezensky T">T. Govezensky</name></author><author><name sortKey="Larralde, C" uniqKey="Larralde C">C. Larralde</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Toh, S Q" uniqKey="Toh S">S.Q. Toh</name></author><author><name sortKey="Glanfield, A" uniqKey="Glanfield A">A. Glanfield</name></author><author><name sortKey="Gobert, G N" uniqKey="Gobert G">G.N. Gobert</name></author><author><name sortKey="Jones, M K" uniqKey="Jones M">M.K. Jones</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Topcu, O" uniqKey="Topcu O">O. Topcu</name></author><author><name sortKey="Sumer, Z" uniqKey="Sumer Z">Z. Sumer</name></author><author><name sortKey="Tuncer, E" uniqKey="Tuncer E">E. Tuncer</name></author><author><name sortKey="Aydin, C" uniqKey="Aydin C">C. Aydin</name></author><author><name sortKey="Koyuncu, A" uniqKey="Koyuncu A">A. Koyuncu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tritten, L" uniqKey="Tritten L">L. Tritten</name></author><author><name sortKey="Silbereisen, A" uniqKey="Silbereisen A">A. Silbereisen</name></author><author><name sortKey="Keiser, J" uniqKey="Keiser J">J. Keiser</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tschen, E H" uniqKey="Tschen E">E.H. Tschen</name></author><author><name sortKey="Tschen, E A" uniqKey="Tschen E">E.A. Tschen</name></author><author><name sortKey="Smith, E B" uniqKey="Smith E">E.B. Smith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tu, Y" uniqKey="Tu Y">Y. Tu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Turner, J D" uniqKey="Turner J">J.D. Turner</name></author><author><name sortKey="Mand, S" uniqKey="Mand S">S. Mand</name></author><author><name sortKey="Debrah, A Y" uniqKey="Debrah A">A.Y. Debrah</name></author><author><name sortKey="Muehlfeld, J" uniqKey="Muehlfeld J">J. Muehlfeld</name></author><author><name sortKey="Pfarr, K" uniqKey="Pfarr K">K. Pfarr</name></author><author><name sortKey="Mcgarry, H F" uniqKey="Mcgarry H">H.F. McGarry</name></author><author><name sortKey="Adjei, O" uniqKey="Adjei O">O. Adjei</name></author><author><name sortKey="Taylor, M J" uniqKey="Taylor M">M.J. Taylor</name></author><author><name sortKey="Hoerauf, A" uniqKey="Hoerauf A">A. Hoerauf</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Turner, J D" uniqKey="Turner J">J.D. Turner</name></author><author><name sortKey="Tendongfor, N" uniqKey="Tendongfor N">N. Tendongfor</name></author><author><name sortKey="Esum, M" uniqKey="Esum M">M. Esum</name></author><author><name sortKey="Johnston, K L" uniqKey="Johnston K">K.L. Johnston</name></author><author><name sortKey="Langley, R S" uniqKey="Langley R">R.S. Langley</name></author><author><name sortKey="Ford, L" uniqKey="Ford L">L. Ford</name></author><author><name sortKey="Faragher, B" uniqKey="Faragher B">B. Faragher</name></author><author><name sortKey="Specht, S" uniqKey="Specht S">S. Specht</name></author><author><name sortKey="Mand, S" uniqKey="Mand S">S. Mand</name></author><author><name sortKey="Hoerauf, A" uniqKey="Hoerauf A">A. Hoerauf</name></author><author><name sortKey="Enyong, P" uniqKey="Enyong P">P. Enyong</name></author><author><name sortKey="Wanji, S" uniqKey="Wanji S">S. Wanji</name></author><author><name sortKey="Taylor, M J" uniqKey="Taylor M">M.J. Taylor</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Utzinger, J" uniqKey="Utzinger J">J. Utzinger</name></author><author><name sortKey="N Oran, E K" uniqKey="N Oran E">E.K. N’Goran</name></author><author><name sortKey="N Ri, A" uniqKey="N Ri A">A. N’Dri</name></author><author><name sortKey="Lengeler, C" uniqKey="Lengeler C">C. Lengeler</name></author><author><name sortKey="Xiao, S" uniqKey="Xiao S">S. Xiao</name></author><author><name sortKey="Tanner, M" uniqKey="Tanner M">M. Tanner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Utzinger, J" uniqKey="Utzinger J">J. Utzinger</name></author><author><name sortKey="Keiser, J" uniqKey="Keiser J">J. Keiser</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Utzinger, J" uniqKey="Utzinger J">J. Utzinger</name></author><author><name sortKey="Xiao, S H" uniqKey="Xiao S">S.H. Xiao</name></author><author><name sortKey="Tanner, M" uniqKey="Tanner M">M. Tanner</name></author><author><name sortKey="Keiser, J" uniqKey="Keiser J">J. Keiser</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Utzinger, J" uniqKey="Utzinger J">J. Utzinger</name></author><author><name sortKey="Tanner, M" uniqKey="Tanner M">M. Tanner</name></author><author><name sortKey="Keiser, J" uniqKey="Keiser J">J. Keiser</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Blitterswijk, W J" uniqKey="Van Blitterswijk W">W.J. van Blitterswijk</name></author><author><name sortKey="Verheij, M" uniqKey="Verheij M">M. Verheij</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Kerckhoven, I" uniqKey="Van Kerckhoven I">I. Van Kerckhoven</name></author><author><name sortKey="Kumar, V" uniqKey="Kumar V">V. Kumar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vargas Villavicencio, J A" uniqKey="Vargas Villavicencio J">J.A. Vargas-Villavicencio</name></author><author><name sortKey="Larralde, C" uniqKey="Larralde C">C. Larralde</name></author><author><name sortKey="De Leon Nava, M A" uniqKey="De Leon Nava M">M.A. De Leon-Nava</name></author><author><name sortKey="Escobedo, G" uniqKey="Escobedo G">G. Escobedo</name></author><author><name sortKey="Morales Montor, J" uniqKey="Morales Montor J">J. Morales-Montor</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vermund, S H" uniqKey="Vermund S">S.H. Vermund</name></author><author><name sortKey="Macleod, S" uniqKey="Macleod S">S. MacLeod</name></author><author><name sortKey="Goldstein, R G" uniqKey="Goldstein R">R.G. Goldstein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Von Samson Himmelstjerna, G" uniqKey="Von Samson Himmelstjerna G">G. von Samson-Himmelstjerna</name></author><author><name sortKey="Harder, A" uniqKey="Harder A">A. Harder</name></author><author><name sortKey="Sangster, N C" uniqKey="Sangster N">N.C. Sangster</name></author><author><name sortKey="Coles, G C" uniqKey="Coles G">G.C. Coles</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Walker, M" uniqKey="Walker M">M. Walker</name></author><author><name sortKey="Rossignol, J F" uniqKey="Rossignol J">J.F. Rossignol</name></author><author><name sortKey="Torgerson, P" uniqKey="Torgerson P">P. Torgerson</name></author><author><name sortKey="Hemphill, A" uniqKey="Hemphill A">A. Hemphill</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, X" uniqKey="Wang X">X. Wang</name></author><author><name sortKey="Zhao, Q" uniqKey="Zhao Q">Q. Zhao</name></author><author><name sortKey="Vargas, M" uniqKey="Vargas M">M. Vargas</name></author><author><name sortKey="Dong, Y" uniqKey="Dong Y">Y. Dong</name></author><author><name sortKey="Sriraghavan, K" uniqKey="Sriraghavan K">K. Sriraghavan</name></author><author><name sortKey="Keiser, J" uniqKey="Keiser J">J. Keiser</name></author><author><name sortKey="Vennerstrom, J L" uniqKey="Vennerstrom J">J.L. Vennerstrom</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wanji, S" uniqKey="Wanji S">S. Wanji</name></author><author><name sortKey="Tendongfor, N" uniqKey="Tendongfor N">N. Tendongfor</name></author><author><name sortKey="Nji, T" uniqKey="Nji T">T. Nji</name></author><author><name sortKey="Esum, M" uniqKey="Esum M">M. Esum</name></author><author><name sortKey="Che, J N" uniqKey="Che J">J.N. Che</name></author><author><name sortKey="Nkwescheu, A" uniqKey="Nkwescheu A">A. Nkwescheu</name></author><author><name sortKey="Alassa, F" uniqKey="Alassa F">F. Alassa</name></author><author><name sortKey="Kamnang, G" uniqKey="Kamnang G">G. Kamnang</name></author><author><name sortKey="Enyong, P A" uniqKey="Enyong P">P.A. Enyong</name></author><author><name sortKey="Taylor, M J" uniqKey="Taylor M">M.J. Taylor</name></author><author><name sortKey="Hoerauf, A" uniqKey="Hoerauf A">A. Hoerauf</name></author><author><name sortKey="Taylor, D W" uniqKey="Taylor D">D.W. Taylor</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wells, T N" uniqKey="Wells T">T.N. Wells</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Who" uniqKey="Who">WHO</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Who" uniqKey="Who">WHO</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Who" uniqKey="Who">WHO</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Wimmersberger, D" uniqKey="Wimmersberger D">D. Wimmersberger</name></author><author><name sortKey="Tritten, L" uniqKey="Tritten L">L. Tritten</name></author><author><name sortKey="Keiser, J" uniqKey="Keiser J">J. Keiser</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xiao, S H" uniqKey="Xiao S">S.H. Xiao</name></author><author><name sortKey="Keiser, J" uniqKey="Keiser J">J. Keiser</name></author><author><name sortKey="Chollet, J" uniqKey="Chollet J">J. Chollet</name></author><author><name sortKey="Utzinger, J" uniqKey="Utzinger J">J. Utzinger</name></author><author><name sortKey="Dong, Y" uniqKey="Dong Y">Y. Dong</name></author><author><name sortKey="Vennerstrom, J L" uniqKey="Vennerstrom J">J.L. Vennerstrom</name></author><author><name sortKey="Tanner, M" uniqKey="Tanner M">M. Tanner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xiao, S H" uniqKey="Xiao S">S.H. Xiao</name></author><author><name sortKey="Xue, J" uniqKey="Xue J">J. Xue</name></author><author><name sortKey="Xu, L L" uniqKey="Xu L">L.L. Xu</name></author><author><name sortKey="Zheng, Q" uniqKey="Zheng Q">Q. Zheng</name></author><author><name sortKey="Qiang, H Q" uniqKey="Qiang H">H.Q. Qiang</name></author><author><name sortKey="Zhang, Y N" uniqKey="Zhang Y">Y.N. Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xiao, S H" uniqKey="Xiao S">S.H. Xiao</name></author><author><name sortKey="Xue, J" uniqKey="Xue J">J. Xue</name></author><author><name sortKey="Li Li, X" uniqKey="Li Li X">X. Li-li</name></author><author><name sortKey="Zhang, Y N" uniqKey="Zhang Y">Y.N. Zhang</name></author><author><name sortKey="Qiang, H Q" uniqKey="Qiang H">H.Q. Qiang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xiao, S H" uniqKey="Xiao S">S.H. Xiao</name></author><author><name sortKey="Mei, J Y" uniqKey="Mei J">J.Y. Mei</name></author><author><name sortKey="Jiao, P Y" uniqKey="Jiao P">P.Y. Jiao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xiao, S H" uniqKey="Xiao S">S.H. Xiao</name></author><author><name sortKey="Xue, J" uniqKey="Xue J">J. Xue</name></author><author><name sortKey="Mei, J Y" uniqKey="Mei J">J.Y. Mei</name></author><author><name sortKey="Jiao, P Y" uniqKey="Jiao P">P.Y. Jiao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xiao, S H" uniqKey="Xiao S">S.H. Xiao</name></author><author><name sortKey="Utzinger, J" uniqKey="Utzinger J">J. Utzinger</name></author><author><name sortKey="Tanner, M" uniqKey="Tanner M">M. Tanner</name></author><author><name sortKey="Keiser, J" uniqKey="Keiser J">J. Keiser</name></author><author><name sortKey="Xue, J" uniqKey="Xue J">J. Xue</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Yakoot, M" uniqKey="Yakoot M">M. Yakoot</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yangco, B G" uniqKey="Yangco B">B.G. Yangco</name></author><author><name sortKey="Klein, T W" uniqKey="Klein T">T.W. Klein</name></author><author><name sortKey="Deresinski, S C" uniqKey="Deresinski S">S.C. Deresinski</name></author><author><name sortKey="Vickery, A C" uniqKey="Vickery A">A.C. Vickery</name></author><author><name sortKey="Craig, C P" uniqKey="Craig C">C.P. Craig</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yawzinski, T A" uniqKey="Yawzinski T">T.A. Yawzinski</name></author><author><name sortKey="Tucker, C" uniqKey="Tucker C">C. Tucker</name></author><author><name sortKey="Featherson, H" uniqKey="Featherson H">H. Featherson</name></author><author><name sortKey="Johnson, Z" uniqKey="Johnson Z">Z. Johnson</name></author><author><name sortKey="Wood Huels, N" uniqKey="Wood Huels N">N. Wood-Huels</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yuan, G" uniqKey="Yuan G">G. Yuan</name></author><author><name sortKey="Xu, J" uniqKey="Xu J">J. Xu</name></author><author><name sortKey="Qu, T" uniqKey="Qu T">T. Qu</name></author><author><name sortKey="Wang, B" uniqKey="Wang B">B. Wang</name></author><author><name sortKey="Zhang, R" uniqKey="Zhang R">R. Zhang</name></author><author><name sortKey="Wei, C" uniqKey="Wei C">C. Wei</name></author><author><name sortKey="Guo, R" uniqKey="Guo R">R. Guo</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Zahner, H" uniqKey="Zahner H">H. Zahner</name></author><author><name sortKey="Taubert, A" uniqKey="Taubert A">A. Taubert</name></author><author><name sortKey="Harder, A" uniqKey="Harder A">A. Harder</name></author><author><name sortKey="Von Samson Himmelstjerna, G" uniqKey="Von Samson Himmelstjerna G">G. von Samson-Himmelstjerna</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhao, Q" uniqKey="Zhao Q">Q. Zhao</name></author><author><name sortKey="Vargas, M" uniqKey="Vargas M">M. Vargas</name></author><author><name sortKey="Dong, Y" uniqKey="Dong Y">Y. Dong</name></author><author><name sortKey="Zhou, L" uniqKey="Zhou L">L. Zhou</name></author><author><name sortKey="Wang, X" uniqKey="Wang X">X. Wang</name></author><author><name sortKey="Sriraghavan, K" uniqKey="Sriraghavan K">K. Sriraghavan</name></author><author><name sortKey="Keiser, J" uniqKey="Keiser J">J. Keiser</name></author><author><name sortKey="Vennerstrom, J L" uniqKey="Vennerstrom J">J.L. Vennerstrom</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zumaquero Rios, J L" uniqKey="Zumaquero Rios J">J.L. Zumaquero-Rios</name></author><author><name sortKey="Sarracent Perez, J" uniqKey="Sarracent Perez J">J. Sarracent-Perez</name></author><author><name sortKey="Rojas Garcia, R" uniqKey="Rojas Garcia R">R. Rojas-Garcia</name></author><author><name sortKey="Rojas Rivero, L" uniqKey="Rojas Rivero L">L. Rojas-Rivero</name></author><author><name sortKey="Martinez Tovilla, Y" uniqKey="Martinez Tovilla Y">Y. Martinez-Tovilla</name></author><author><name sortKey="Valero, M A" uniqKey="Valero M">M.A. Valero</name></author><author><name sortKey="Mas Coma, S" uniqKey="Mas Coma S">S. Mas-Coma</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zumla, A" uniqKey="Zumla A">A. Zumla</name></author><author><name sortKey="Keiser, J" uniqKey="Keiser J">J. Keiser</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="review-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Int J Parasitol Drugs Drug Resist</journal-id><journal-id journal-id-type="iso-abbrev">Int J Parasitol Drugs Drug Resist</journal-id><journal-title-group><journal-title>International Journal for Parasitology: Drugs and Drug Resistance</journal-title></journal-title-group><issn pub-type="epub">2211-3207</issn><publisher><publisher-name>Elsevier</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25516827</article-id><article-id pub-id-type="pmc">4266803</article-id><article-id pub-id-type="publisher-id">S2211-3207(14)00015-3</article-id><article-id pub-id-type="doi">10.1016/j.ijpddr.2014.07.002</article-id><article-categories><subj-group subj-group-type="heading"><subject>Invited Review</subject></subj-group></article-categories><title-group><article-title>Repurposing drugs for the treatment and control of helminth infections</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Panic</surname><given-names>Gordana</given-names></name></contrib><contrib contrib-type="author"><name><surname>Duthaler</surname><given-names>Urs</given-names></name></contrib><contrib contrib-type="author"><name><surname>Speich</surname><given-names>Benjamin</given-names></name></contrib><contrib contrib-type="author"><name><surname>Keiser</surname><given-names>Jennifer</given-names></name><email>jennifer.keiser@unibas.ch</email><xref rid="cor1" ref-type="corresp">⁎</xref></contrib></contrib-group><aff id="af005">Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland</aff><aff id="af010">University of Basel, P.O. Box, CH-4003 Basel, Switzerland</aff><author-notes><corresp id="cor1"><label>⁎</label>Corresponding author. Address: Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, P.O. Box, CH-4002 Basel, Switzerland. Tel.: +41 61 284 8218; fax: +41 61 284 8105. <email>jennifer.keiser@unibas.ch</email></corresp></author-notes><pub-date pub-type="pmc-release"><day>30</day><month>7</month><year>2014</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="epub"><day>30</day><month>7</month><year>2014</year></pub-date><pub-date pub-type="collection"><month>12</month><year>2014</year></pub-date><volume>4</volume><issue>3</issue><fpage>185</fpage><lpage>200</lpage><history><date date-type="received"><day>16</day><month>4</month><year>2014</year></date><date date-type="rev-recd"><day>4</day><month>7</month><year>2014</year></date><date date-type="accepted"><day>13</day><month>7</month><year>2014</year></date></history><permissions><copyright-statement>© 2014 The Authors</copyright-statement><copyright-year>2014</copyright-year><license license-type="CC BY-NC-ND" xlink:href="http://creativecommons.org/licenses/by-nc-nd/3.0/"><license-p>This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).</license-p></license></permissions><abstract abstract-type="graphical"><title>Graphical abstract</title><fig id="f0010" position="anchor"><graphic xlink:href="fx1"></graphic></fig></abstract><abstract abstract-type="author-highlights"><title>Highlights</title><p><list list-type="simple"><list-item id="o0005"><label>•</label><p>Drug repurposing continues to be the central drug discovery strategy for helminths.</p></list-item><list-item id="o0010"><label>•</label><p>Most repurposed drugs come from veterinary medicine and known drug classes.</p></list-item><list-item id="o0015"><label>•</label><p>Only a handful of drugs have advanced clinically.</p></list-item><list-item id="o0020"><label>•</label><p>More collaborations and funding are needed to advance discoveries to the market.</p></list-item></list></p></abstract><abstract><p>Helminth infections are responsible for a considerable public health burden, yet the current drug armamentarium is small. Given the high cost of drug discovery and development, the high failure rates and the long duration to develop novel treatments, drug repurposing circumvents these obstacles by finding new uses for compounds other than those they were initially intended to treat. In the present review, we summarize <italic>in vivo</italic> and clinical trial findings testing clinical candidates and marketed drugs against schistosomes, food-borne trematodes, soil-transmitted helminths, <italic>Strongyloides stercoralis</italic>, the major human filariases lymphatic filariasis and onchocerciasis, taeniasis, neurocysticercosis and echinococcosis. While expanding the applications of broad-spectrum or veterinary anthelmintics continues to fuel alternative treatment options, antimalarials, antibiotics, antiprotozoals and anticancer agents appear to be producing fruitful results as well. The trematodes and nematodes continue to be most investigated, while cestodal drug discovery will need to be accelerated. The most clinically advanced drug candidates include the artemisinins and mefloquine against schistosomiasis, tribendimidine against liver flukes, oxantel pamoate against trichuriasis, and doxycycline against filariasis. Preclinical studies indicate a handful of promising future candidates, and are beginning to elucidate the broad-spectrum activity of some currently used anthelmintics. Challenges and opportunities are further discussed.</p></abstract><kwd-group><title>Keywords</title><kwd>Drug repurposing</kwd><kwd>Drug repositioning</kwd><kwd>Helminths</kwd><kwd>Anthelmintic</kwd><kwd>Schistosoma</kwd><kwd>Trematodes</kwd><kwd>Soil-transmitted helminths</kwd><kwd>Cestodes</kwd></kwd-group></article-meta></front><body><sec sec-type="intro" id="s0005"><label>1</label><title>Introduction</title><p>Helminth infections caused by roundworms (nematodes) and flatworms (platyhelminths) comprise the greatest group of the neglected tropical diseases (NTDs) (<xref rid="b0420" ref-type="bibr">Hotez et al., 2006</xref>). An estimated 11.5 million disability adjusted life years (DALYs) are attributed to intestinal nematode infections, schistosomiasis, lymphatic filariasis, onchocerciasis, food-borne trematodiasis, cysticercosis and echinococcosis (<xref rid="b0765" ref-type="bibr">Murray et al., 2012</xref>). Most of the burden of these diseases results from disability (rather than premature death), influencing school attendance, child development and overall economic productivity, thus resulting in disease driven poverty traps (<xref rid="b0420" ref-type="bibr">Hotez et al., 2006</xref>). In a recent special issue of the Disease Clinics of North America (<xref rid="b1295" ref-type="bibr">Zumla and Keiser, 2012</xref>), cestode infestations (<xref rid="b0160" ref-type="bibr">Brunetti and White, 2012</xref>), schistosomiasis (<xref rid="b0370" ref-type="bibr">Gryseels, 2012</xref>), food-borne trematodiases (<xref rid="b0325" ref-type="bibr">Fürst et al., 2012</xref>), filariases (<xref rid="b0635" ref-type="bibr">Knopp et al., 2012a</xref>) and soil-transmitted helminthiases (<xref rid="b0640" ref-type="bibr">Knopp et al., 2012b</xref>) were presented in great detail and hence for background information on these diseases, the reader is referred to these excellent publications.</p><p>Preventive chemotherapy is the strategy of choice to control schistosomiasis, soil-transmitted helminthiases, lymphatic filariasis, onchocerciasis and food-borne trematodiases yet as emphasized in the following sections of this review, limited tools are available to treat these infections. In addition, for many of the available drugs, resistance is a threat since it has already developed in veterinary medicine and many of the drugs have an imperfect activity profile. Yet clear targets have been set to eliminate and control several of these diseases (<ext-link ext-link-type="uri" xlink:href="http://www.unitingtocombatntds.org/downloads/press/london_declaration_on_ntds.pdf" id="ir0005">http://www.unitingtocombatntds.org/downloads/press/london_declaration_on_ntds.pdf</ext-link>). Hence research and development (R&D) to find the next generation of anthelmintics is indispensable. However, a recent systematic assessment of databases of drug regulatory authorities and the World Health Organization (WHO) as well as clinical trial registries revealed a dry drug pipeline for NTDs, supported by the fact that no new chemical entity had been approved for these diseases in the past decade (<xref rid="b1315" ref-type="bibr">Pedrique et al., 2013</xref>).</p><p>Drug repurposing (also termed re-profiling, re-tasking, therapeutic switching or drug repositioning) is the process of developing new indications for existing, failed or abandoned drugs or advanced clinical candidates (<xref rid="b0920" ref-type="bibr">Sekhon, 2013</xref>). Drug repurposing is a useful strategy to accelerate the drug development process due to lower costs, reduced risk and decreased time to market due to availability of preclinical data (<xref rid="b0800" ref-type="bibr">Padhy and Gupta, 2011</xref>). This enables not only pharmaceutical companies but also public-sector researchers to engage in drug discovery and development efforts (<xref rid="b0785" ref-type="bibr">O’Connor and Roth, 2005</xref>), and hence might result in treatment options for diseases almost exclusively addressed by public sector researchers, such as the neglected tropical diseases. Over the past years, a variety of drug-repurposing initiatives have been launched with particular attention to neglected tropical and rare diseases (<xref rid="b0045" ref-type="bibr">Allarakhia, 2013</xref>), hence it is likely that these efforts will bear fruit in the next years.</p><p>The aim of the present article is to highlight the status of drug repurposing for neglected helminth diseases. The focus is on the state-of-the-art treatments and how drug repurposing has been supplying the drug development pipeline for schistosomiasis, infections with major food-borne trematodes, <italic>Fasciola</italic> spp., <italic>Opisthorchis</italic> spp. and <italic>Clonorchis sinensis</italic>, soil-transmitted helminthiasis<italic>, Strongyloides stercoralis</italic>, the major human filariasis, lymphatic filariasis and onchocerciasis, taeniasis, neurocysticercosis and echinococcosis.</p><p>Our review complements a recent article by Andrews and colleagues which summarized antiprotozoal drug repurposing for major parasitic protozoal diseases including malaria, trypanosomiasis, and leishmaniasis (<xref rid="b0055" ref-type="bibr">Andrews et al., 2014</xref>).</p></sec><sec id="s0010"><label>2</label><title>Schistosomiasis and food-borne trematodiases</title><sec id="s0015"><label>2.1</label><title>Current treatment</title><p>Since its discovery in the 1970s, praziquantel has replaced many other drugs as the sole treatment for a range of helmintic infections. Praziquantel is effective against all three major species of <italic>Schistosoma</italic> (<italic>S. mansoni</italic>, <italic>S. haematobium</italic> and <italic>S. japonicum</italic>), and is the standard treatment against <italic>C. sinensis</italic>, <italic>Opisthorchis viverrini</italic> and <italic>Opisthorchis felineus</italic>, and intestinal flukes (<xref rid="b0490 b1075" ref-type="bibr">Keiser and Utzinger, 2004; Utzinger and Keiser, 2004</xref>). It is administered orally, is safe, and highly effective.</p><p>As mentioned above, preventive chemotherapy is the strategy of choice to control schistosomiasis (<xref rid="b1130" ref-type="bibr">WHO, 2006</xref>). This program is expected to expand ten-fold to include the treatment of 235 million people by 2018 (<xref rid="b0645" ref-type="bibr">Knopp et al., 2013</xref>) which, on the one hand may significantly drive down morbidity and transmission but, on the other hand, would exacerbate drug pressure, likely resulting in resistance to praziquantel (<xref rid="b0180" ref-type="bibr">Caffrey, 2007</xref>). Furthermore, praziquantel still has deficiencies: it is inactive against the juvenile stage of <italic>Schistosoma</italic> spp. and its (S)-enantiomer is inactive, a problem because at the moment, it is not separated from the (R)-enantiomer in production and hence the tablets are large and bitter (<xref rid="b1005" ref-type="bibr">Stothard et al., 2013</xref>). Therefore, there is great motivation to seek alternative medications.</p><p>In the case of fascioliasis, triclabendazole is the treatment of choice (<xref rid="b0525" ref-type="bibr">Keiser et al., 2005</xref>). Triclabendazole is safe and effective against both the human and veterinary forms of the disease. However, there are two major setbacks: in veterinary medicine, triclabendazole resistance has already been documented (<xref rid="b1230" ref-type="bibr">Brennan et al., 2007</xref>). Additionally, triclabendazole is not registered for use in many nations, and is therefore not always available for the treatment of human fascioliasis (<xref rid="b0525" ref-type="bibr">Keiser et al., 2005</xref>).</p></sec><sec id="s0020"><label>2.2</label><title>Repurposed drugs</title><sec id="s0025"><label>2.2.1</label><title>Antimalarials and their derivatives</title><p>The largest anthelmintic drug repurposing success story by far has been the application of antimalarials against a wide variety of trematode infections, as well as other broader applications. Investigations of the use of antimalarials against <italic>Schistosoma</italic> spp. and the liver flukes are based on the rationale that these flukes have the same blood-feeding characteristic as <italic>Plasmodium</italic> spp., and therefore share heme degradation mechanisms (<xref rid="b1035" ref-type="bibr">Toh et al., 2010</xref>). If antimalarials target this pathway, they may also be effective against blood-digesting flukes. However, antimalarials have shown activity also against the non-blood feeding intestinal flukes (<xref rid="b0445" ref-type="bibr">Ingram et al., 2012b</xref>), not only indicating their broad-spectrum activity, but also hinting at other mechanisms of action. As emphasized earlier, the use of antimalarials in de-worming programs should be eyed with caution, as this could accelerate resistance to these drugs. Nevertheless, since malaria and schistosome infections largely overlap geographically, the wide use of antimalarials might be beneficial in co-infected patients (<xref rid="b0520" ref-type="bibr">Keiser and Utzinger, 2012</xref>).</p><sec id="s0170"><label>2.2.1.1</label><title>Artemisinins</title><p><italic>Artemisia annua</italic> (<italic>quinghao</italic>) has been used for thousands of years in Chinese medicine for a wide range of ailments, yet its antimalarial properties did not become known to the wider world until the 1970s, despite its prevalence as a common herb (<xref rid="b1055" ref-type="bibr">Tu, 2011</xref>). Artemisinin, the plant’s active ingredient, is a sesquiterpene lactone, with a characteristic peroxide bridge that is widely believed to be the active pharmacophore. Though potent, its short half-life, poor bioavailability and the reliance on plant cultivation spurred a search for semi-synthetic and completely synthetic alternatives (<xref rid="b0395" ref-type="bibr">Ho et al., 2014</xref>). The most widely used artemisinin-derivatives are the first-generation semi-synthetics artesunate and artemether. Artemisinin-based therapies have shown great efficacy against <italic>Schistosoma</italic> spp., <italic>Fasciola</italic> spp., <italic>Opisthorchis</italic> spp. and <italic>C. sinensis</italic>, as summarized in previous reviews (<xref rid="b0500 b0520 b1080" ref-type="bibr">Keiser and Utzinger, 2007b, 2012; Utzinger et al., 2007</xref>). Briefly, artemether, artesunate and dihydroartemisinin (the active metabolite of all artemisinin compounds) share common antischistosomal therapeutic characteristics. <italic>In vivo</italic> studies have demonstrated that these artemisinins are highly effective against juvenile infections and only moderately effective against adult infections (<xref rid="b0520 b0700" ref-type="bibr">Keiser and Utzinger, 2012; Li et al., 2014</xref>). This observation suggests that these drugs particularly show clinical benefit when used as prophylactic treatments. Indeed, as calculated by a recent meta-analysis by Liu and colleagues, administration of multiple low doses of artemether or artesunate over a 1–2 week period achieved a protection rate of 65–97% against schistosomiasis japonicum (<xref rid="b0710" ref-type="bibr">Liu et al., 2011</xref>). In addition, a decreased risk was observed using artemether for the prevention of <italic>S. mansoni</italic> and <italic>S. haematobium</italic> infections (<xref rid="b1070 b0780" ref-type="bibr">Utzinger et al. 2000; N’Goran et al. 2003</xref>). Contradictory findings were obtained when these agents were used in the treatment of chronic infections. While some studies reported high efficacy, low to moderate cure rates (CRs) were observed in other trials (<xref rid="b0495" ref-type="bibr">Keiser and Utzinger, 2007a</xref>). However, overall the therapeutic effect of artesunate, artemether or artemisinin based combination therapy (ACTs) against schistosomiasis was inferior to praziquantel in clinical trials (<xref rid="b0495 b1085" ref-type="bibr">Keiser and Utzinger, 2007a; Utzinger et al., 2010</xref>). Finally, the artemisinins often showed synergistic effects with praziquantel in clinical trials, as elucidated by two meta-analyses (<xref rid="b0710 b0825" ref-type="bibr">Liu et al., 2011; Perez del Villar et al., 2012</xref>).</p><p>The artemisinins have also been thoroughly characterized against food-borne trematodes in <italic>in vivo</italic> studies. Artemether and artesunate were both found to be very effective against the liver flukes <italic>Fasciola hepatica</italic> and <italic>C. sinensis</italic>, as well as the intestinal fluke <italic>Echinostoma caproni</italic> in the rodent infection models, achieving complete worm clearance (<xref rid="b0530 b0540 b0545" ref-type="bibr">Keiser et al., 2006a,c,d</xref>), though lower worm burden reductions (WBRs) were achieved in the <italic>O. viverrini</italic> hamster infection model (66% and 78% for artemether and artesunate, respectively, administered as a single oral dose of 400 mg/kg) (<xref rid="b0545" ref-type="bibr">Keiser et al., 2006d</xref>). Artemether and artesunate administered to sheep naturally infected with <italic>F. hepatica</italic> also achieved significant WBRs (91.3% at a dose of 140 mg/kg intramuscular (i.m.) and 91.9% at a dose of 40 mg/kg i.m. respectively), though embryotoxicity and toxicity were of potential concern (<xref rid="b0560 b0600" ref-type="bibr">Keiser et al., 2008a, 2010e</xref>).</p><p>Studies with the artemisinins have progressed to clinical trials in <italic>Fasciola-</italic>infected patients: in central Vietnam, patients subjected to a 10-day treatment course with artesunate, administered daily at a dose of 4 mg/kg, were less likely to report abdominal pain at hospital discharge than patients treated with a standard oral dose of 10 mg/kg triclabendazole. However, 3 months post-treatment, clinical and serological response rates were lower among artesunate recipients compared to triclabendazole-treated patients (<xref rid="b0390" ref-type="bibr">Hien et al., 2008</xref>). This result mirrors an exploratory Phase 2 trial conducted in Egypt, where chronically infected patients treated with 6 × 80 mg and 3 × 200 mg artemether only achieved CRs of 35 and 6%, respectively (<xref rid="b1245" ref-type="bibr">Keiser et al., 2011</xref>). Finally, low CR and egg reduction rate (ERR) of 4% and 32% were also observed after administration of artesunate (10 mg/kg in 3 split doses) to school-aged children infected with <italic>O. viverrini</italic> (<xref rid="b0950" ref-type="bibr">Soukhathammavong et al., 2011</xref>).</p></sec><sec id="s0175"><label>2.2.1.2</label><title>Synthetic peroxides</title><p>The success of the semi-synthetic artemisinins along with their pharmacologic draw-backs motivated the creation of fully synthetic derivatives in antimalarial drug discovery, the most investigated of these being the synthetic ozonides. The antimalarial OZ439 is currently in Phase 2 clinical trials (<xref rid="b1125" ref-type="bibr">Wells, 2013</xref>). Two synthetic trioxolanes in particular have been widely investigated as potential anthelmintics- OZ78 and OZ288- whose trematocidal activity has been reviewed by <xref rid="b0500" ref-type="bibr">Keiser and Utzinger (2007b)</xref>. The review highlights the major <italic>in vivo</italic> studies which reveal interesting properties of these two compounds. First, their activity is comparable to those of the artemisinins and they exhibit the same increased <italic>in vivo</italic> activity against juvenile <italic>S. mansoni</italic> as compared to adult worms in mice and in hamsters. Second, in <italic>S. mansoni in vivo</italic> models, the adult WBR is affected by the rodent model, achieving only moderate WBRs in the mouse but high WBRs in the hamster model. However follow-up studies indicated similarly significant activity of OZ78 against <italic>S. japonicum</italic> juvenile and adult infection in hamsters, mice and rabbits, and of OZ277 in hamsters (<xref rid="b1170 b1175" ref-type="bibr">Xiao et al., 2011, 2012</xref>). Interestingly, the ozonide OZ418 was recently found to be active against both juvenile and adult worms in the mouse <italic>S. mansoni</italic> infection model, and the adult <italic>S. haematobium</italic> hamster infection model (<xref rid="b0610" ref-type="bibr">Keiser et al., 2012a</xref>), as well as moderately active against 7 day-old and adult <italic>S. japonicum-</italic> infected mice (<xref rid="b1185" ref-type="bibr">Xue et al. 2014</xref>)- a result which shows that further modifications of the aryl ozonides can yield promising compounds.</p><p>With regard to the food-borne trematodes, <italic>in vivo</italic> activity of OZ78 against the liver flukes <italic>F. hepatica</italic> and <italic>C. sinensis</italic> and the intestinal fluke <italic>E. caproni</italic> is very high but studies with <italic>O. viverrini</italic> showed no activity at all (<xref rid="b0505" ref-type="bibr">Keiser and Utzinger, 2007c</xref>)<italic>.</italic> Importantly, in follow-up studies, OZ78 was found to be effective against triclabendazole-resistant <italic>F. hepatica</italic> (100% WBR at oral dose of 100 mg/kg) (<xref rid="b0550" ref-type="bibr">Keiser et al., 2007a</xref>). Oddly, the high activity of the OZs against <italic>F. hepatica</italic> could not be repeated in naturally-infected sheep, regardless of the administration route (<xref rid="b0585 b0755" ref-type="bibr">Keiser et al., 2010b; Meister et al., 2013</xref>). This discrepancy could potentially be explained by pharmacokinetic differences observed in rat and sheep, as discussed by Meister and colleagues (<xref rid="b0755" ref-type="bibr">Meister et al., 2013</xref>).</p><p>Where OZ78 failed to treat <italic>F. hepatica</italic> in sheep, MT04 succeeded. MT04 is another synthetic peroxide, identified in the search for more effective analogues, which was found to have a 92% WBR and a 99% ERR in naturally infected sheep (<xref rid="b1275 b1285 b0755" ref-type="bibr">Zhao et al., 2010; Wang et al., 2011; Meister et al., 2013</xref>).</p></sec><sec id="s0040"><label>2.2.1.3</label><title>Mefloquine</title><p>Mefloquine is a 4-quinolinemethanol whose discovery as an antimalarial dates to around the same time as the artemisinins. Its antischistosomal activity was revealed in 2008 and was thoroughly covered in a review by <xref rid="b1180" ref-type="bibr">Xiao et al. (2013)</xref>. This review highlights some excellent antischistosomal properties of mefloquine. First, it is active against all three major <italic>Schistosoma</italic> spp. and against both the juvenile and adult stages, a characteristic that neither praziquantel nor the artemisinins possess. Second, it causes severe morphological damage to the fluke and acts independently of the host immune response. Third, initial results from clinical trials were promising; mefloquine- artesunate achieved an ERR of 95% against <italic>S. haematobium</italic> in school-aged children (<xref rid="b0590" ref-type="bibr">Keiser et al., 2010c</xref>). In addition, pregnant women who used mefloquine as intermittent preventive treatment for the prevention of malaria showed significantly higher CRs and ERRs against <italic>S. haematobium</italic> than women treated with sulfadoxine-pyrimethamine (<xref rid="b0110" ref-type="bibr">Basra et al., 2013</xref>). Moreover, mefloquine-related arylmethanols also show antischistosomal activity <italic>in vivo</italic> (<xref rid="b0440" ref-type="bibr">Ingram et al., 2012a</xref>).</p><p>The effectiveness of mefloquine against food-borne trematodes was briefly reviewed by <xref rid="b0580" ref-type="bibr">Keiser et al. (2010a)</xref>. This review highlighted that mefloquine is not active against <italic>F. hepatica</italic> nor <italic>C. sinensis</italic>, but interestingly, mefloquine was active against juvenile and adult <italic>O. viverini</italic> in a hamster infection model, achieving a WBR of 89% and 96% respectively, following a single oral dose of 300 mg/kg (<xref rid="b0570" ref-type="bibr">Keiser et al., 2009a</xref>). However, mefloquine failed to produce an effect against <italic>O. viverini</italic> in clinical trials (<xref rid="b0950" ref-type="bibr">Soukhathammavong et al., 2011</xref>). In a later study, mefloquine yielded significant results against <italic>C. sinensis</italic> infection in a rat model (when given at multiple dosages) and <italic>Paragonimus westermani</italic> infection in a dog model, but the results were not better than a treatment with praziquantel (<xref rid="b1165" ref-type="bibr">Xiao et al., 2010</xref>).</p></sec></sec><sec id="s0045"><label>2.2.2</label><title>Tribendimidine</title><p>Also originating from China, tribendimidine is a Chinese anthelmintic drug which has a similar activity profile against the soil-transmitted helminths as albendazole (high activity against <italic>Ascaris lumbricoides</italic> and hookworms but only moderate activity against <italic>Trichuris trichiura</italic>) (<xref rid="b1180" ref-type="bibr">Xiao et al., 2013</xref>). Besides its broad range of antinematodal activity, tribendimidine has demonstrated trematocidal activity <italic>in vivo</italic> against <italic>C. sinensis</italic> and <italic>O. viverrini</italic> (<xref rid="b0580 b1180" ref-type="bibr">Keiser et al., 2010a; Xiao et al., 2013</xref>). A recent randomized open-label trial in Guangxi, PR China presented moderate CRs (44% following a single dose of 400 mg/kg and 58% following 400 mg/kg administered once daily for 3 days) and high ERR (98–99%), similar to praziquantel. Tribendimidine compared favorably to praziquantel with regards to appearance of adverse events (<xref rid="b0830" ref-type="bibr">Qian et al., 2013</xref>). Similarly, tribendimidine cured 19 of 24 patients infected with <italic>O. viverrini</italic> and achieved an ERR of 99% (<xref rid="b0950" ref-type="bibr">Soukhathammavong et al., 2011</xref>). Further studies with tribendimidine are currently ongoing (e.g. dose-finding, pharmacokinetic studies) in <italic>O. viverrini-</italic>infected patients in Laos with the ultimate goal of developing an alternative opisthorchicidal drug.</p><p>To offset eventual resistance to praziquantel, using tribendimidine in combination with praziquantel is an attractive option. However, a recent study showed that praziquantel-tribendimidine administered to <italic>O. viverrini-</italic>infected hamsters, though achieving synergistic effects <italic>in vitro</italic>, had antagonistic effects in the hamster murine model (<xref rid="b0620" ref-type="bibr">Keiser et al., 2013a</xref>). Further studies are required to shed light on this phenomenon. In contrast, in the <italic>C. sinensis</italic> rat model, tribendimidine (12.5–50 mg/kg) showed synergistic interactions with 150 mg/kg praziquantel (<xref rid="b0575" ref-type="bibr">Keiser et al., 2009b</xref>).</p></sec><sec id="s0050"><label>2.2.3</label><title>Other compounds</title><p>The most recent <italic>in vivo</italic> antitrematodal candidates come from a range of sources and fields, including cancer research, though expanding veterinary drug applications continues to be popular. The discoveries are described below and summarized in <xref rid="t0005" ref-type="table">Table 1</xref>.</p><sec id="s0055"><label>2.2.3.1</label><title>S. mansoni</title><p>A (well-funded) cancer drug pipeline provides a cornucopia of compounds. <xref rid="b0270" ref-type="bibr">Dissous and Grevelding (2011)</xref> recently explored the potential of repurposing cancer drugs, specifically protein kinase inhibitors, towards schistosomiasis. The principal rationale was the identification of select protein kinases as being essential to schistosome development and the subsequent identification of certain cancer drugs as inhibitors of these kinases. However, most of the drugs discussed were only inhibitors of egg development and had little effect on the adult worms themselves. The one exception was imatinib (Gleevec), a successful anti-leukemia agent, which was shown to be lethal to adult worms <italic>in vitro</italic> at high concentrations (<xref rid="b0120" ref-type="bibr">Beckman and Grevelding, 2010</xref>). However, imatinib was ineffective in an <italic>S. mansoni</italic> infection model (<xref rid="t0005" ref-type="table">Table 1</xref>) (<xref rid="b0485" ref-type="bibr">Katz et al., 2013</xref>) which is not surprising, as the drug is highly bound to alpha-1-acid glycoprotein (<xref rid="b0935" ref-type="bibr">Soo et al. 2010</xref>).</p><p>Nonetheless, two anticancer agents have shown promising <italic>in vivo</italic> activity. Miltefosine, an alkylphospholipid, was initially developed to combat cutaneous metastasis of mammary carcinomas (<xref rid="b1090" ref-type="bibr">van Blitterswijk and Verheij, 2013</xref>). As discussed in a complementary review by <xref rid="b0055" ref-type="bibr">Andrews et al. (2014)</xref>, it has also recently been licensed to treat leishmaniasis- a protozoan that also has cutaneous manifestations, though this drug treats both the visceral and cutaneous forms (<xref rid="b0280" ref-type="bibr">Dorlo et al., 2012</xref>). Recently, it has shown <italic>in vivo</italic> activity in the <italic>S. mansoni</italic> mouse model at various stages of infection. Administered at 20 mg/kg for five consecutive days, commencing either on the day of infection (schistosomula stage), 21 days p.i. or 42 days p.i., miltefosine showed WBRs of 91%, 76% and 95%, respectively (<xref rid="b0290" ref-type="bibr">Eissa et al., 2011a</xref>). A recent study by Eissa and colleagues also demonstrated its ovicidal, larvicidal and molluscicidal activity and its <italic>in vitro</italic> activity against <italic>S. haematobium</italic> adult worms (<xref rid="b0295" ref-type="bibr">Eissa et al., 2011b</xref>). Interestingly, our own studies have shown that miltefosine was only moderately active against newly transformed schistosomula (NTS) of <italic>S. mansoni</italic> (unpublished findings).</p><p>The antiandrogen, nilutamide, blocks the binding of testosterone to the androgen receptor and was initially marketed for the treatment of metastatic prostate cancer (<xref rid="b0035" ref-type="bibr">Akaza, 2011</xref>). Recently, we have tested it in the <italic>S. mansoni</italic> mouse model since related hydantoin derivatives studied at Hoffmann-La Roche had intriguing antischistosomal properties (<xref rid="b0705" ref-type="bibr">Link and Stohler, 1984</xref>) – a single 400 mg/kg oral dose achieved a WBR of 85% and an even higher WBR was observed when given in combination with praziquantel (<xref rid="b0595" ref-type="bibr">Keiser et al., 2010d</xref>). However, nilutamide did display a stage specific effect – it was only moderately active against the juvenile stage (<xref rid="b0595" ref-type="bibr">Keiser et al., 2010d</xref>).</p><p>The advantages and disadvantages of using cancer drugs in the treatment of helmintic diseases should be carefully weighed. On the one hand, there is a great deal of effort to minimize toxic effects of cancer drugs due to their long treatment course. If a cancer drug is deemed safe when administered over a long period, there is a good chance it is also safe as an anthelmintic, where treatment is annual or twice annual (if part of regular preventive chemotherapy programs) but short (i.e. single dose). However, due to the severity and life threatening state of many cancers, the benefit of taking the drugs may outweigh potential severe adverse events. Thus, just because a drug is approved for cancer treatment, does not mean it is without significant adverse events. Yet a drug used in preventive chemotherapy programs must have an excellent tolerability profile.</p><p>Extending the application of veterinary anthelmintics continues to be a source of human anthelmintic candidates<italic>.</italic><xref rid="b0015" ref-type="bibr">Abdulla et al. (2009)</xref> showed that rafoxanide, a salicylanilide derivative and a veterinary anthelmintic, caused a 50–56% WBR in mice at a single oral dose of 50 mg/kg. This compound was identified from a screen of a commercially available FDA-approved library. This same screen also identified anisomycin, lasalocid sodium, diffractic acid, gamboic acid and niclosamide as hits for <italic>in vivo</italic> testing in the <italic>S. mansoni</italic> mouse model. Unfortunately, these drugs failed to reduce worm burden <italic>in vivo,</italic> the exception being lasalocid sodium which caused a WBR of 41–44% when administered at 100 mg/kg orally. Rafoxanide was not originally in the library, but due to niclosamide’s excellent <italic>in vitro</italic> profile (but poor <italic>in vivo</italic> results), rafoxanide was tested as well, as it is structurally related to niclosamide. Clorsulon (a veterinary flukicidal drug) caused a WBR in <italic>S. mansoni-</italic>infected mice of 88%, 96% and 98% when treated with either a single, double or triple dose of 5 mg/kg one week apart starting from the 4th week postinfection (<xref rid="b0760" ref-type="bibr">Mossallam et al., 2007</xref>). Yet in our own studies only moderate activity against NTS were observed <italic>in vitro</italic> when the NTS were incubated with 10 μM clorsulon for 72 h (unpublished observations).</p><p>Another re-purposing strategy is to increase the anthelmintic spectrum of activity through slight modification of the molecule. For example, BTP-Iso, a novel benzimidazole (in the same family as triclabendazole) was recently investigated as an antischistosomal. At a dose of 300 mg/kg given to <italic>S. mansoni-</italic>infected mice, BTP-Iso showed statistically significant higher reductions (<italic>p</italic> < 0.01) in female (77%), male (35%), and total worms (55%) in comparison with the control group (<xref rid="b0300" ref-type="bibr">El Bialy et al., 2013</xref>).</p></sec><sec id="s0060"><label>2.2.3.2</label><title>F. hepatica</title><p>Two fasciocidal drugs were moved directly into clinical testing, without previous publications of <italic>in vivo</italic> studies. In Iran, 46 patients who were positive for <italic>Fasciola</italic> 3 months after triclabendazole treatment were given 1.5 g/day metronidazole orally for three weeks. Two months after end of therapy, stool exams became negative in 35 patients (81%), of which 31 patients (72%) presented both negative serology and stool exams. At 12 months, 28 patients were examined and all were negative (<xref rid="b1250" ref-type="bibr">Mansour-Ghanaei et al., 2003</xref>).</p><p>Nitazoxanide, a thiazolide derivative and a pyruvate ferredoxin oxireductase inhibitor, has a broad spectrum of activity. The US Food and Drug Administration (FDA) approved nitazoxanide in 2002 for the treatment of diarrhea caused by <italic>Cryptosporidium</italic> species and <italic>Giardia intestinalis</italic> in pediatric patients 1–11 years of age, and in 2004 for its use in adults (<xref rid="b0385" ref-type="bibr">Hemphill et al., 2006</xref>). Two clinical trials elucidated nitazoxanide’s fasciocidal effects. In northern Peru, a double-blind placebo-controlled trial showed moderate effects in children and adults: a 7-day course of nitazoxanide resulted in CRs of 60% in adults and 40% in children (<xref rid="b0315" ref-type="bibr">Favennec et al., 2003</xref>). In the Atlixco municipality in Mexico, a study carried out in 50 Mexican schoolchildren showed nitazoxanide to be effective against light <italic>F. hepatica</italic> infections. Children diagnosed with fascioliasis were administered nitazoxanide at 7.5 mg/kg body weight, every 12 hours over seven days. The efficacy against fascioliasis was 94% and 100% after first and second treatment courses, respectively. Its efficacy was also very high against protozoan and intestinal helminths (<xref rid="b1290" ref-type="bibr">Zumaquero-Rios et al., 2013</xref>). However, this second study did not have a control group, and therefore could not be compared to a placebo or treatment with triclabendazole. Given these somewhat contradictory findings, larger randomized control trials should be conducted to elucidate the role of nitazoxanide in the treatment of fascioliasis.</p><p>Myrrh has been marketed as an antischistosomal, though its actual effect is controversial (<xref rid="b0010 b1190" ref-type="bibr">Abdul-Ghani et al., 2009; Yakoot, 2010</xref>). Despite a 2004 field trial in Egypt, showing a CR of 88% and 94% CR, 2 and 3 months after treatment (<xref rid="b0020" ref-type="bibr">Abo-Madyan et al., 2004</xref>), the overall consensus based on bench and field publications is that it is ineffective as a fasciocidal agent (<xref rid="b0140 b0580" ref-type="bibr">Botros et al., 2009; Keiser et al., 2010a</xref>).</p><p>In the veterinary field, the benzimidazoles are often used as broad-spectrum anthelmintics, as discussed further in the soil-transmitted helminths section below. In livestock, the use of oxfendazole has previously been restricted to the treatment of roundworm, strongyloides and pinworm infection. However, very recently, it was demonstrated that it has potent anti-flukicidal activity: 100% WBR was achieved after a single oral dose of 30 mg/kg was given to <italic>F. hepatica</italic> infected pigs (<xref rid="b0795" ref-type="bibr">Ortiz et al. 2014</xref>).</p></sec></sec></sec></sec><sec id="s0065"><label>3</label><title>Soil-transmitted helminthiasis and strongyloides</title><sec id="s0070"><label>3.1</label><title>Current treatment</title><p>The two benzimidazoles, albendazole and mebendazole, as well as pyrantel pamoate and levamisole are the four available treatments against soil-transmitted helminths, marketed between 1966 (pyrantel pamoate) and 1980 (albendazole) (<xref rid="b0515 b1140" ref-type="bibr">Keiser and Utzinger, 2010; WHO, 2013</xref>). These drugs are widely used (in 2010, 328 million children were treated with albendazole or mebendazole (<xref rid="b0075" ref-type="bibr">Anonymous, 2012</xref>)) since, as mentioned, the current strategy to control morbidity due to the most common soil-transmitted helminths (<italic>A. lumbricoides</italic>, <italic>T. trichiura</italic> and the hookworm species <italic>Ancylostoma duodenale</italic> and <italic>Necator americanus</italic>) is by regular treatment of at risk populations (<xref rid="b1130 b1135" ref-type="bibr">WHO, 2006, 2011</xref>). The limitations of these drugs are widely known. Briefly, using a single dose regimen they all are very efficacious against <italic>A</italic>. <italic>lumbricoides</italic>, yet for the treatment of hookworm infections only albendazole produces satisfying CRs, while all drugs achieve poor CRs against infections with <italic>T. trichiura</italic> (<xref rid="b0510" ref-type="bibr">Keiser and Utzinger, 2008</xref>). As no new anthelmintic drugs are on the horizon, repurposing of existing drugs is an essential strategy to improve treatment of soil-transmitted helminths, particularly <italic>T. trichiura</italic> infections (<xref rid="b0510 b0790" ref-type="bibr">Keiser and Utzinger, 2008; Olliaro et al., 2011</xref>).</p><p>The current drug of choice against <italic>S. stercoralis</italic> infections is ivermectin, which is widely used in mass drug administration programs to combat lymphatic filariasis (<xref rid="b0635" ref-type="bibr">Knopp et al., 2012a</xref>). A single dose of 200 μg/kg results in a CR of 88% against <italic>S. stercoralis</italic> (<xref rid="b0515" ref-type="bibr">Keiser and Utzinger, 2010</xref>). The drug has the disadvantages that it is not licensed for treating <italic>S. stercoralis</italic> infections in several countries (e.g. Switzerland, Germany, Great Britain), that the ideal dosage schedule of ivermectin has yet to be evaluated, and that it can cause harmful and dangerous treatment effects in individuals co-infected with <italic>Loa loa</italic> which is an insect-borne filarial infection (<xref rid="b0130 b0365" ref-type="bibr">Bisoffi et al., 2013; Greaves et al., 2013</xref>). People not tolerating ivermectin can alternatively use albendazole, which is inferior compared to ivermectin regarding ERRs and CRs; however, it still achieves satisfactory efficacy (<xref rid="b0515 b0635" ref-type="bibr">Keiser and Utzinger, 2010; Knopp et al., 2012a</xref>). In addition, mebendazole achieves CRs and ERRs of 67–98% against <italic>S. stercoralis</italic> when given in multiple doses (<xref rid="b0770 b0925 b0930 b1210" ref-type="bibr">Musgrave et al., 1979; Shikiya et al., 1990, 1991; Zaha et al., 2000</xref>). Of note, even though ivermectin is not listed as an essential drug against soil-transmitted helminths (<xref rid="b1140" ref-type="bibr">WHO, 2013</xref>), several studies have shown that by combining ivermectin with the standard drug albendazole or mebendazole, the efficacy against soil-transmitted helminths (especially against <italic>T. trichiura</italic>) can be improved significantly (a summary of trials is presented in <xref rid="b0615" ref-type="bibr">Keiser et al. (2012b)</xref>).</p></sec><sec id="s0075"><label>3.2</label><title>Repurposed drugs</title><sec id="s0080"><label>3.2.1</label><title>Drugs evaluated in clinical testing</title><sec id="s0085"><label>3.2.1.1</label><title>Nitazoxanide</title><p>Nitazoxanide, mentioned above for its protozoan and fasciocidal properties, showed (in manufacturer-financed trials) very high CRs against <italic>A. lumbricoides</italic>, <italic>T. trichiura</italic>, <italic>S. stercoralis</italic> and even against <italic>A. duodenale</italic> when the drug was given in multiple doses (<xref rid="b0885 b0005 b0460 b0265" ref-type="bibr">Romero Cabello et al., 1997; Abaza et al., 1998; Juan et al., 2002; Diaz et al., 2003</xref>). The drug also demonstrated superior activity than the standard drugs in <italic>in vitro</italic> screening against <italic>Trichuris muris</italic> (<xref rid="b1045" ref-type="bibr">Tritten et al., 2012</xref>). However, a recent clinical trial using a single dose of 1000 mg nitazoxanide could not confirm the initial results obtained in earlier trials and in the laboratory. Nitazoxanide achieved low CRs and ERRs (7% and 13%, respectively) against <italic>T. trichiura</italic> in school-aged children on Pemba, Tanzania<italic>.</italic> Additionally the drug was slightly less well tolerated compared to standard treatment and hence nitazoxanide was not recommended as an alternative treatment against soil-transmitted helminthiasis (<xref rid="b0960" ref-type="bibr">Speich et al., 2012</xref>). Of note, within the same trial, the efficacy of a single dose nitazoxanide (1000 mg) against intestinal protozoa was also only moderate (<xref rid="b0965" ref-type="bibr">Speich et al., 2013</xref>).</p></sec><sec id="s0090"><label>3.2.1.2</label><title>Oxantel pamoate</title><p>Oxantel pamoate, a veterinary drug which was introduced on the market in 1974, revealed high efficacy against <italic>T. trichiura</italic> in a number of exploratory trials (<xref rid="b0335 b0680 b0685" ref-type="bibr">Garcia, 1976; Lee et al., 1976; Lee and Lim, 1978</xref>). The drug was only revisited recently, more than three decades later. Laboratory studies demonstrated a significantly higher activity of oxantel pamoate compared to the benzimidazoles, levamisole or pyrantel pamoate against <italic>T. muris in vitro</italic> and <italic>in vivo</italic> (<xref rid="b0625" ref-type="bibr">Keiser et al., 2013b</xref>). A randomized controlled double blind trial recently confirmed the high efficacy of oxantel pamoate (20 mg/kg) against <italic>T. trichiura</italic> (26% CR and 93% ERR)<italic>.</italic> Hence oxantel pamoate-albendazole, due to its broad spectrum of activity could be useful in the control of soil-transmitted helminthiasis (<xref rid="b0970" ref-type="bibr">Speich et al., 2014</xref>). Further studies have been planned with the ultimate goal of elucidating the potential of adding oxantel pamoate to the current drug armamentarium.</p></sec><sec id="s0095"><label>3.2.1.3</label><title>Tribendimidine</title><p>A large phase 2 trial in Côte d’Ivoire confirmed the excellent activity of tribendimidine against hookworm and <italic>A. lumbricoides</italic> (N’Goran et al. under review). Following promising results with tribendimidine against <italic>Strongyloides ratti</italic> in the rat model (<xref rid="b1240" ref-type="bibr">Keiser et al., 2008b</xref>) an exploratory trial in China documented a CR of 55% in patients infected with <italic>S. stercoralis</italic> (<xref rid="b1270" ref-type="bibr">Steinmann et al., 2008</xref>).</p></sec><sec id="s0100"><label>3.2.1.4</label><title>The benzimidazoles</title><p>The benzimidazoles are a large family, widely used in veterinary medicine, and not only include albendazole and mebendazole (and the fasciocidal drug triclabendazole mentioned earlier) but also flubendazole, fenbendazole, oxfendazole, thiabendazole and oxibendazole (<xref rid="b0790" ref-type="bibr">Olliaro et al., 2011</xref>). In addition, oxfendazole and cambendazole are promising broad spectrum benzimidazoles used in veterinary medicine, which have not yet been tested in humans. The benzimidazoles have a broad spectrum of activity including whipworms, roundworms and hookworms. For example, multiple doses of thiabendazole have similarly high efficacy against <italic>S. stercoralis</italic> as compared to ivermectin, however the drug was less tolerated (<xref rid="b0330 b1210 b0125" ref-type="bibr">Gann et al., 1994; Zaha et al., 2000; Bisoffi et al., 2011</xref>). Clinical trials conducted with flubendazole, fenbendazole, oxibendazole and thiabendazole against soil-transmitted helminths and <italic>S. stercoralis</italic> are summarized in <xref rid="t0010" ref-type="table">Table 2</xref>.</p></sec></sec><sec id="s0185"><label>3.2.2</label><title>Compounds in early clinical testing and potential veterinary drugs</title><p>An excellent summary of potential drug development candidates for human soil-transmitted helminthiasis has recently been provided by Olliaro and colleagues (<xref rid="b0790" ref-type="bibr">Olliaro et al., 2011</xref>).</p><p>Four promising compound classes are worth highlighting. First, emodepside is a cyclic depsipeptide and a broad-spectrum veterinary anthelmintic used for companion animal gastrointestinal nematode infections (<xref rid="b0380 b0360" ref-type="bibr">Harder et al., 2003; Geary and Mackenzie, 2011</xref>). It showed high activity against <italic>Trichuris</italic> spp., <italic>Ancylostoma</italic> spp. and other nematodes in <italic>in vitro</italic> and <italic>in vivo</italic> studies (<xref rid="b0375 b0050" ref-type="bibr">Harder and von Samson-Himmelstjerna, 2002; Altreuther et al., 2009</xref>). Moreover, the closely related PF1022A was potent in clearing <italic>T. muris</italic> infections in mice at various stages of infection (<xref rid="b0660" ref-type="bibr">Kulke et al. 2014</xref>). <italic>In vivo</italic> studies on <italic>Haemonchus contortus</italic> have shown that it has a different mode of action than the benzimidazoles and ivermectin (<xref rid="b1110" ref-type="bibr">von Samson-Himmelstjerna et al., 2005</xref>) hence the drug will likely be active against parasites resistant to the benzimidazoles and ivermectin.</p><p>Second, doramectin which belongs to the avermectins, showed high efficacy against <italic>S. ransomi</italic>, <italic>S. papillosus</italic>, <italic>T. suis</italic> and <italic>A. suum</italic> in pigs (<xref rid="b0995 b1200" ref-type="bibr">Stewart et al., 1996; Yawzinski et al., 1997</xref>) as well as against <italic>Trichuris</italic> spp. in cattle (<xref rid="b0455 b0900" ref-type="bibr">Jones et al., 1993; Saeki et al., 1995</xref>). Doramectin showed even more favorable results against nematodes compared to ivermectin, which could be explained by its lower clearance and higher bioavailability (<xref rid="b0715" ref-type="bibr">Lumaret et al., 2012</xref>). The closely related milbemycin family is also a potent drug class. Milbemycin oxime has proven to be efficacious against <italic>Ascaris</italic> spp., hookworm and <italic>Trichuris</italic> spp. in cats and dogs (<xref rid="b0135 b0190" ref-type="bibr">Blagburn et al., 1992; Catton and Van Schalkwyk, 2003</xref>). On the other hand only low ERRs were found against <italic>T. trichiura</italic> in baboons (<xref rid="b1265" ref-type="bibr">Reichard et al., 2007</xref>).</p><p>Third, moxidectin is another commercially available broad-spectrum antiparasitic from the veterinary field (<xref rid="b0850" ref-type="bibr">Reinemeyer and Cleale, 2002</xref>). It is a semisynthetic methoxime derivative of naturally occurring nemadectin with a novel mode of action (<xref rid="b0100" ref-type="bibr">Awasthi et al., 2013</xref>). Moxidectin showed high efficacy in several <italic>in vivo</italic> studies (i.e. in cattle, swine, sheep) against <italic>Ascaris</italic> spp., <italic>Trichuris</italic> spp. and <italic>Strongyloides</italic> spp. (<xref rid="b0115 b0220 b1000 b0850 b0835 b0720" ref-type="bibr">Bauer and Conraths, 1994; Coles et al., 1994; Stewart et al., 1999; Reinemeyer and Cleale, 2002; Ranjan and DeLay, 2004; Lyons et al., 2006</xref>).</p><p>Finally, from a completely different medical arena, cyclosporine A is an immunosuppressive agent which is commonly used for organ transplantation (<xref rid="b0215" ref-type="bibr">Cohen et al., 1984</xref>). Its antischistosomal properties were first described in 1981 (<xref rid="b0165" ref-type="bibr">Bueding et al., 1981</xref>) followed by studies against <italic>S. stercoralis</italic> in dogs and <italic>S. ratti</italic> in rats (<xref rid="b0085" ref-type="bibr">Armson et al., 1995</xref>). Treatment with cyclosporine A seems to be of benefit in cases of opportunistic, possibly life threatening infections of <italic>S. stercoralis</italic> activated by immunosuppression (<xref rid="b0915" ref-type="bibr">Schad, 1986</xref>).</p></sec></sec></sec><sec id="s0110"><label>4</label><title>Filariasis</title><sec id="s0115"><label>4.1</label><title>Current treatment</title><p>Though filariasis is a collection of diseases, the three major control programs target lymphatic filariasis (Global Program to Eliminate Lymphatic Filariasis) or onchocerciasis (African Program for Onchocerciasis Control and the Onchocerciasis Elimination Program for the Americas), and a major cornerstone of all three programs is mass drug administration. Regardless of the disease, the recommended treatments are limited: ivermectin, albendazole and diethylcarbamazine (DEC), ivermectin being the most widely recommended drug. The use and status of these drugs, including their limitations, have recently been reviewed by <xref rid="b0480" ref-type="bibr">Katiyar and Singh (2011)</xref>. Briefly, resistance to ivermectin has already been documented and its administration to onchocerciasis patients co-infected with loaiasis results in severe adverse events (<xref rid="b0465" ref-type="bibr">Kamgno et al., 2007</xref>). Albendazole’s efficacy is heavily debated and DEC is contraindicated in patients with onchocerciasis (<xref rid="b0480" ref-type="bibr">Katiyar and Singh, 2011</xref>). Additionally, the treatment regimens required for these drugs in order to fully stop transmission are long: according to current control guidelines, ivermectin or DEC-albendazole need to be administered once a year for 5 years to interrupt LF transmission (<xref rid="b0070 b0080" ref-type="bibr">Anonymous, 2009, 2014</xref>). The long treatment schedule is partly because all three drugs predominantly act on microfilaria only (the larvae shed by the adult worms), with DEC showing some adult stage activity (<xref rid="b0285" ref-type="bibr">Dreyer et al., 2006</xref>). This latter point is problematic, as the adult stage still survives in the host, ready to shed more microfilaria once the drugs are absent from the host, continuing to cause pathology in onchocerciasis patients and also continuing the transmission cycle. Thus, new drug candidates should necessarily target adult worms as well. Additionally, as all filariasis-causing nematodes (except <italic>L. loa</italic>) carry with them the endosymbiotic <italic>Wolbachia</italic> bacteria necessary for the parasite’s development, efforts have been made to target these bacteria.</p></sec><sec id="s0120"><label>4.2</label><title>Drugs targeting <italic>Wolbachia</italic></title><p>Amongst the new antifilarial drugs<italic>,</italic> doxycycline is the most studied. It is a broad-spectrum antibacterial and antiprotozoal whose effects against <italic>Wolbachia</italic> are considered a breakthrough in antifilarial treatment (<xref rid="b0480" ref-type="bibr">Katiyar and Singh, 2011</xref>). In onchocerciasis patients, a treatment regimen of 100 mg of doxycycline per day for 6 weeks slowly eliminated <italic>Wolbachia</italic> and resulted in long-term embryogenesis block of the adult worms (<xref rid="b0400" ref-type="bibr">Hoerauf et al., 2003</xref>). The death of <italic>Wolbachia</italic> also leads to macrofilaricidal effects, as adults worms extracted from LF patients treated with 200 mg of doxycycline per day for 4 weeks were found to be either sterile or dead (<xref rid="b0245" ref-type="bibr">Debrah et al., 2007</xref>). Findings by Taylor and colleagues also showed macrofilaricidal effects in LF patients, though the same level of potency could not be observed in onchocerciasis patients (<xref rid="b1020 b0410" ref-type="bibr">Taylor et al., 2005; Hoerauf et al., 2008b</xref>). In addition, doxycycline is potentially microfilaricidal as well, as shown in LF patients treated with 100–200 mg per day for 6 weeks (<xref rid="b1010" ref-type="bibr">Supali et al., 2008</xref>). Doxycycline, given prior to antifilarial treatment, appears to be more effective in suppressing microfilaremia in bancroftian filariasis over the long term than the standard treatments alone, while also resulting in fewer severe adverse events (<xref rid="b1060" ref-type="bibr">Turner et al., 2006</xref>). LF symptoms could also be reduced by doxycycline, regardless of active filarial infection as demonstrated in a trial in Ghana (<xref rid="b0735" ref-type="bibr">Mand et al., 2012</xref>). This symptomatic alleviation also extends to LF patients who presented with hydrocele (<xref rid="b0250" ref-type="bibr">Debrah et al., 2009</xref>).</p><p>The effects of doxycycline administered in combination with the standard drugs have also been characterized. For example, a combination of doxycycline and albendazole was far more effective at suppressing circulating microfilaria than doxycycline or albendazole alone (nearly 100% suppression vs. 69% and 89%, respectively when checked at day 365 post-treatment) and even succeeded in completely clearing 42% of patients of microfilaremia (<xref rid="b0355" ref-type="bibr">Gayen et al., 2013</xref>). Different trials also assessed doxycycline/ivermectin and found that the combination was more effective than ivermectin or doxycycline alone (<xref rid="b1300 b1065" ref-type="bibr">Masud et al., 2009; Turner et al., 2010</xref>). Similarly, a 21-day course of doxycycline at 200 mg administered orally to LF patients in Orissa, India, followed by a single 6 mg/kg dose of DEC was effective at completely clearing microfiladermia. Interestingly, the co-administration of doxycycline followed by DEC was also effective at clearing adult worm nests, and less effective when the doxycycline treatment was shortened to 10 days (<xref rid="b0730" ref-type="bibr">Mand et al., 2009</xref>).</p><p>Doxycycline was even found to be effective against <italic>Mansonella perstans</italic>, one of two agents that cause serous cavity filariasis. In a randomized open-label trial in Mali, 97% and 75% of <italic>M. perstans</italic> patients treated with 200 mg doxycycline for 6 weeks were found to be amicrofilaremic at 12 and 36 months post-treatment, respectively. This finding is very significant as the current standard treatments are not effective against <italic>M. perstans</italic> (<xref rid="b0230" ref-type="bibr">Coulibaly et al., 2009</xref>).</p><p>Last but not least, given that <italic>L. loa</italic> is the only filarial nematode that does not possess <italic>Wolbachia</italic> endosymbionts, the use of <italic>Wolbachia</italic>-targeting antibiotics is a possible safe alternative for the treatment of this disease. Doxycycline was already shown to be safe in onchocerciasis patients co-infected with loaisis (<xref rid="b1280 b1065" ref-type="bibr">Wanji et al., 2009; Turner et al., 2010</xref>), but its long treatment course leaves room for short-course therapy innovations.</p><p>Considering the importance of a potent anti-<italic>Wolbachia</italic> treatment, there is ongoing research to also elucidate the effects of other potent broad-spectrum antibiotics on <italic>Wolbachia</italic>. Rifampicin was found to be effective in reducing <italic>Wolbachia</italic> bacteria, as well as embryogenesis and microfilaria production in a small number of onchocerciasis patients, though not as efficiently as doxycycline (<xref rid="b0955" ref-type="bibr">Specht et al., 2008</xref>). However a short-course therapy of 5 days rifampicin was documented to be completely ineffective (<xref rid="b0870" ref-type="bibr">Richards et al., 2007</xref>). Meanwhile azithromycin was observed to be only marginally effective against <italic>Wolbachia</italic> and showed no effect on the worms in onchocerciasis patients in Ghana (<xref rid="b0405" ref-type="bibr">Hoerauf et al., 2008a</xref>). In another study, oxytetracycline (the parent compound of doxycycline) had macrofilaricidal properties in cattle infected with <italic>Onchocerca ochengi</italic>, however this success has yet to be translated to human treatment (<xref rid="b0775" ref-type="bibr">Nfon et al., 2007</xref>).</p></sec><sec id="s0125"><label>4.3</label><title>Drugs targeting the worms</title><p>As mentioned above, drugs effective against the filarial adult stage should be investigated with high priority. The potential of the benzimidazole flubendazole, a veterinary drug used to treat gastrointestinal nematode infection, as a pre-clinical macrofilaricide candidate for preventive treatment of onchocerciasis and lymphatic filariasis is currently being studied in a project lead by the Drugs for Neglected Diseases <italic>initiative</italic> (DND<italic>i</italic>). These investigations have been reviewed by <xref rid="b0725" ref-type="bibr">Mackenzie and Geary (2011)</xref>. In the late 1980s and early 1990s, flubendazole was shown to be macrofilaricidal against a variety of filariases-causing agents <italic>in vivo</italic> and even in a clinical trial for onchocerciasis (<xref rid="b0275 b1095 b0320" ref-type="bibr">Dominguez-Vazquez et al., 1983; Van Kerckhoven and Kumar, 1988; Franz et al., 1990</xref>). Interestingly, it has no microfilaricidal effects (<xref rid="b1095" ref-type="bibr">Van Kerckhoven and Kumar, 1988</xref>), which indicates that it could be safe for <italic>L. loa</italic> co-infected patients as well. The drug is, however, very poorly orally absorbed and hence the current focus of the project lead by DND<italic>i</italic> is to improve the drug’s bioavailability. A new cyclodextrin formulation is currently being investigated with mixed results: while it achieved higher plasma concentrations when administered orally to <italic>Echinococcus granulosus-</italic>infected mice, no significant pharmacokinetic effects were observed when it was administered to sheep via the intraruminal nor the intraabomasal route (<xref rid="b0195 b0205" ref-type="bibr">Ceballos et al., 2009, 2012</xref>).</p><p>Nonetheless, other drugs on the horizon continue to target microfilaria while also having some effects on the adult stage. Unsurprisingly, moxidectin has shown potent microfilaricidal effects and long term sterilization of females. Furthermore, early-stage clinical trials have shown that it is safe and well tolerated in humans in doses of 3–36 mg and has a longer half-life than ivermectin (<xref rid="b0225 b0095" ref-type="bibr">Cotreau et al., 2003; Awadzi et al. 2014</xref>). It is being evaluated in ongoing Phase 2 and 3 clinical trials via a partnership between APOC, TDR and Wyeth (<xref rid="b1025 b0105" ref-type="bibr">Taylor et al., 2009; Babalola, 2011</xref>). Nonetheless, tolerability studies are needed to confirm that moxidectin is safe in patients co-infected with <italic>L. loa</italic> and whether the drug is efficacious against ivermectin-resistant filaria.</p><p>Other anthelmintics tested include the above mentioned cyclic depsipeptides, emodepside and PF1022A, and levamisole. Emodepside showed potent microfilaricidal effects and even some macrofilaricidal effects (but not against <italic>Brugia malayi</italic>) <italic>in vivo</italic> (<xref rid="b1215" ref-type="bibr">Zahner et al., 2001</xref>), hence there is great interest in the potential of emodepside as a novel antifilarial (<ext-link ext-link-type="uri" xlink:href="http://r4d.dfid.gov.uk/PDF/Outputs/DNDI/evolutions_of_dndi_portfolio.pdf" id="ir0010">http://r4d.dfid.gov.uk/PDF/Outputs/DNDI/evolutions_of_dndi_portfolio.pdf</ext-link>). With regards to levamisole, though previous studies from the 1980s showed it had no significant treatment effect for LF or onchocerciasis patients (<xref rid="b0090 b1305" ref-type="bibr">Awadzi et al., 1982; McMahon, 1981</xref>), the drug was revisited in a clinical trial in 2004 where levamisole was given alone (2.5 mg/kg) or co-administered with ivermectin or albendazole. Here as well, it proved to be ineffective, alone or in combination (<xref rid="b1310" ref-type="bibr">Awadzi et al., 2004</xref>).</p><p>Nitazoxanide, mentioned earlier in this review, and its metabolite tizoxanide were tested against <italic>B. malayi</italic> worms <italic>in vitro</italic> and <italic>in vivo.</italic> The drugs were lethal to adult worms at 20 μg/ml and significantly decreased microfilaria release at 5 μg/ml. However, they were ineffective against <italic>Wolbachia</italic> and eventually were shown to be ineffective in clearing the worms <italic>in vivo</italic> (<xref rid="b1260" ref-type="bibr">Rao et al., 2009</xref>).</p><p>Considering the success of antimalarials against trematodes, as well as the co-endemicity of malaria and many helmintic diseases, it is always tempting to test antimalarials on other worms as well. Recently, an open randomized control trial investigated the effects of the antimalarials quinine, chloroquine, amodiaquine and artesunate, based on previous <italic>in vivo</italic> successes or case studies, on patients infected with <italic>L. loa.</italic> However<italic>,</italic> none of the treatments were found to be effective (<xref rid="b0470" ref-type="bibr">Kamgno et al., 2010</xref>).</p></sec></sec><sec id="s0130"><label>5</label><title>Cestode infections</title><sec id="s0135"><label>5.1</label><title>Current treatment</title><p>Niclosamide, originally developed as a molluscicide, was introduced in 1959 as the first synthetic drug against taeniasis, characterized by an excellent therapeutic index and high efficacy (<xref rid="b1145" ref-type="bibr">WHO/FAO/OIE, 2005</xref>). It is a poorly water soluble halogenated salicylanilide with a low bioavailability, which is an advantage since a systemic action is not desired (<xref rid="b0810 b1145" ref-type="bibr">Pearson and Hewlett, 1985; WHO/FAO/OIE, 2005</xref>). Approximately one decade later, in 1972, the taenicidal activity of praziquantel, an acylated isoquinoline-pyranzine, was discovered jointly by Bayer AG and E. Merck (<xref rid="b0060" ref-type="bibr">Andrews et al., 1983</xref>). Both drugs are still the recommended first line treatments against intestinal cestodes including <italic>Taenia solium</italic>, <italic>Taenia saginata</italic>, <italic>Diphyllobothrium</italic> spp. and <italic>Hymenolepis nana</italic> (<xref rid="b1145" ref-type="bibr">WHO/FAO/OIE, 2005</xref>). Praziquantel, which is well absorbed from the intestine, presents additional activity against <italic>T. solium</italic> cysticerci located in the host’s tissues (i.e. central nervous system, subcutaneous tissue, and the eye). A single oral dose of praziquantel is highly effective against taeniasis; nevertheless multiple treatment courses over 2 weeks are recommended for uncomplicated cysticercosis. Albendazole, is also recommended for the treatment of (neuro)-cysticercosis and is generally more active than praziquantel (<xref rid="b0940 b0945 b1015 b1145" ref-type="bibr">Sotelo et al., 1988, 1990; Takayanagui and Jardim, 1992; WHO/FAO/OIE, 2005</xref>). Regardless, therapy for neurocysticercosis needs to be individualized depending on the patient’s state of disease. Anthelmintics, surgery, and symptomatic treatment with analgesics, corticosteroid drugs, and antiepileptic drugs, to relieve headache, perilesional inflammation and seizures, are the main pillars of the therapeutic approach (<xref rid="b0185 b1235" ref-type="bibr">Carpio, 2002; Garcia et al., 2011</xref>).</p><p>Surgical resection of the entire parasitic lesion is indicated in all operable cases of cystic and alveolar echinococcosis. Puncture-aspiration-injection-re-aspiration (PAIR) treatment is applied in inoperable cases of cystic echinococcosis: cysts are punctured and exposed to protoscolicidal substances (i.e. ethanol 95%) for at least a quarter of an hour (<xref rid="b0065" ref-type="bibr">WHO, 1996</xref>). Chemotherapy is key to preventing secondary echinococcosis and to reducing the risk of re-occurrence following surgery (<xref rid="b0155" ref-type="bibr">Brunetti et al., 2010</xref>). Mebendazole and albendazole are both recommended for the treatment of echinococcosis. The albendazole dose regimen is more convenient because its phase-1 metabolite, albendazole sulfoxide, also exhibits metacestodicidal properties and thus the drug disposition is greater than for mebendazole (<xref rid="b0435" ref-type="bibr">Ingold et al., 1999</xref>). Praziquantel itself possesses less pronounced activity against echinococcosis than albendazole. Combination treatment of praziquantel and albendazole seems sensible, because both drugs display a different mechanism of action and praziquantel increases the bioavailability of albendazole sulfoxide when the two are given together (<xref rid="b0210 b0630 b1235" ref-type="bibr">Cobo et al., 1998; Kern, 2006; Garcia et al., 2011</xref>). Nonetheless, insufficient clinical data are available to provide treatment recommendations for this combination (<xref rid="b0805 b0175" ref-type="bibr">Pawłowski, 2001; Bygott and Chiodini, 2009</xref>).</p></sec><sec id="s0140"><label>5.2</label><title>Repurposed drugs</title><sec id="s0145"><label>5.2.1</label><title>Taeniasis and neurocysticercosis</title><p>The food and drug administration (FDA) approved nitazoxanide, mentioned several times earlier in this review, as an antiprotozoal agent against <italic>Cryptosporidium</italic> species and <italic>Giardia intestinalis</italic> in 2002 (<xref rid="b0890" ref-type="bibr">Rossignol, 2009</xref>). Its chemical structure stems from the taenicide niclosamide and therefore, unsurprisingly, activity was reported against <italic>T. saginata</italic> and <italic>H. nana</italic> infections in the 1980s (<xref rid="t0015" ref-type="table">Table 3</xref>) (<xref rid="b0895" ref-type="bibr">Rossignol and Maisonneuve, 1984</xref>). Hence, nitazoxanide is not a genuine example of a repurposed drug for taeniasis; still its strong taenicidal activity makes it attractive for off-label use in cases where patients do not respond to praziquantel or niclosamide (<xref rid="b1105 b0675" ref-type="bibr">Vermund et al., 1986; Lateef et al., 2008</xref>). Similarly, quinacrine (mepacrine), which is an ancient antimalarial agent and antigiardial drug, can be used to treat niclosamide-tolerant <italic>T. saginata</italic> infections (<xref rid="b0345 b0650" ref-type="bibr">Gardner et al., 1996; Koul et al., 2000</xref>).</p><p>The recent promising results achieved with tribendimidine against <italic>O. viverrini</italic> and <italic>C. sinensis</italic> liver fluke infections (see above) inspired further exploration of its anthelmintic activity profile against cestodes. In an open-label randomized clinical trial, including 15 patients infected with <italic>Taenia</italic> spp., a single oral dose of 200 mg (5–14 year old children) or 400 mg (⩾15 years) tribendimidine resulted in a CR of 67%. Due to diagnostic challenges and the relatively small numbers of patient enrolled in the study, the authors pointed out that the observed cestocidal effect of tribendimidine should rather be recognized as an indication of possible activity rather than as a proof-of-concept (<xref rid="b1270" ref-type="bibr">Steinmann et al., 2008</xref>). A distinct anticestodal potential of tribendimidine was demonstrated in mice infected with <italic>Hymenolepis microstoma</italic>, where a triple dose of 50 mg/kg tribendimidine, given over three consecutive days, achieved a WBR of more than 95% (<xref rid="b0655" ref-type="bibr">Kulke et al., 2012</xref>). No cestocidal effect was observed however, when mice were treated with deacetylated amidantel. This result is somehow unexpected as deacetylated amidantel is supposed to be the major active metabolite of tribendimidine, hence further studies are required (<xref rid="b1160 b1205" ref-type="bibr">Xiao et al., 2009; Yuan et al., 2010</xref>).</p><p>Paromomycin (Humatin®) is an aminoglycoside antibiotic with activity against gram-negative and various gram-positive bacteria. It is marketed to decrease bacterial load in the gut in hepatic coma, and for the treatment of amoebiasis and giardiasis. Recently, it has been licensed in India for leishmaniasis therapy (<xref rid="b0235" ref-type="bibr">Davidson et al., 2009</xref>). In the 1960s the taenicidal activity of paromomycin was discovered by chance in the course of amoebiasis treatments, where co-infected patients shed segments of <italic>T. saginata</italic> (<xref rid="b0905" ref-type="bibr">Salem and el-Allaf, 1969</xref>)<italic>.</italic> In a follow-up clinical study it was demonstrated that daily treatments for 1–3 days with 30–50 mg/kg paromomycin resulted in a success rate of 89–100% against <italic>T. saginata</italic>. In addition, an efficacy of approximately 90% was observed against <italic>H. nana</italic> following a 30 mg/kg single or double dose of paromomycin (<xref rid="b0905" ref-type="bibr">Salem and el-Allaf, 1969</xref>).</p><p>Tamoxifen is a first generation selective estrogen receptor modulator (SERM), which acts as an antagonist on estrogen receptors in breast tissue, while possessing an agonistic effect in other tissues. It is used as an adjuvant for breast cancer and the palliative treatment of metastatic or locally advanced mamma carcinoma (<xref rid="b0260" ref-type="bibr">den Hollander et al., 2013</xref>). It has been demonstrated that estradiol plays an essential role in regulating the asexual reproduction of <italic>Taenia crassiceps</italic> cysticerci in mice, possibly by interfering with the host’s cellular immune response (<xref rid="b1030" ref-type="bibr">Terrazas et al., 1994</xref>), and as a result, tamoxifen was tested against <italic>T. crassiceps</italic> cysticerci. Tamoxifen reduced the parasite load by 80% and 50% in female and male mice, respectively. In addition, loss of motility and reduced reproduction could be demonstrated <italic>in vitro</italic> (<xref rid="b1100" ref-type="bibr">Vargas-Villavicencio et al., 2007</xref>). A follow-up study showed that tamoxifen decreased the intestinal establishment of <italic>T. solium</italic> in hamsters by approximately 70%. Moreover, tamoxifen induced morphological changes: the recovered tapeworms appeared like scolices without strobilar development and consequently showed an 80% reduction in length (<xref rid="b0310" ref-type="bibr">Escobedo et al., 2013</xref>). Yet the taenicidal and cysticidal potential of tamoxifen has not been evaluated in humans and livestock.</p><p>Metrifonate is an organophosphorous compound applied as an insecticide and veterinary anthelmintic. In humans it has been, for example, for the treatment of schistosomiasis (<xref rid="b0415" ref-type="bibr">Holmstedt et al., 1978</xref>). A case report published in 1981 about a man with a heavy cutaneous cysticercosis infection, described that two treatment courses of metrifonate at 10 mg/kg/day for six days were able to clear about 75% of the nodules and reduced the size of the remaining ones. Nevertheless, the observed adverse drug events caused by metrifonate’s unspecific cholinesterase inhibition were so strong that atropine had to be given to relieve the symptoms (<xref rid="b1050" ref-type="bibr">Tschen et al., 1981</xref>).</p></sec><sec id="s0150"><label>5.2.2</label><title>Echinococcosis</title><p><italic>In vitro</italic> and <italic>in vivo</italic> studies indicate that <italic>Echinococcus multilocularis</italic> and <italic>E. granulosus</italic> can be included in the broad activity spectrum of nitazoxanide. <italic>In vitro</italic> treatment of <italic>E. multilocularis</italic> metacestodes with nitazoxanide lead to morphological and ultrastructure alterations and inhibited larval growth, while <italic>E. granulosus</italic> protoscoleces and metacestodes suffered deleterious effects as well (<xref rid="b0985 b1115 b0865" ref-type="bibr">Stettler et al., 2003; Walker et al., 2004; Reuter et al., 2006</xref>). Subsequent <italic>in vivo</italic> experiments showed that a combination of nitazoxanide and albendazole reduced parasite weight by about 4 times in the murine model (<xref rid="b0990" ref-type="bibr">Stettler et al., 2004</xref>). A good effect was observed in patients with disseminated cystic echinococcosis on affected soft tissue, muscles, or viscera, who received nitazoxanide additionally to the standard albendazole chemotherapy (with or without praziquantel). Nevertheless, nitazoxanide shows no effect on chronic and extensive body lesions (<xref rid="b0820" ref-type="bibr">Perez-Molina et al., 2011</xref>).</p><p>A 3-month treatment course with the anticancer drugs daunorubicin, idarubicin, cytarabine, and fludarabine did not affect the size and contents of the echinococcus cysts in a patient suffering from acute leukemia and cystic echinococcosis of the liver. The antifungal agent amphotericin B was additionally applied within the chemotherapy schedule, but did not show parasitocidal activity against <italic>E. granulosus</italic> cysts either (<xref rid="b0040" ref-type="bibr">Ali et al., 2005</xref>). However, <italic>in vitro</italic> data suggest that amphotericin B effectively inhibits the growth of <italic>E. multilocularis</italic> metacestodes (<xref rid="b0860" ref-type="bibr">Reuter et al., 2003b</xref>). Amphotericin B is also able to halt parasite growth in <italic>E. multilocularis-</italic>infected patients and might therefore play a role as salvage treatment, when resistance or intolerance to benzimidazoles occurs (<xref rid="b0855" ref-type="bibr">Reuter et al., 2003a</xref>).</p><p>The anthelmintic agent ivermectin was tested against <italic>E. multilocularis</italic> in hamsters with intraperitoneal inoculation of protoscolices, and in rats with transportal inoculation of protoscolices. The drug showed no effect in either case (<xref rid="b0430" ref-type="bibr">Inaoka et al., 1987</xref>). In addition, <italic>in vitro</italic> results confirmed that ivermectin is also ineffective against <italic>E. multilocularis</italic> larvae (<xref rid="b0865" ref-type="bibr">Reuter et al., 2006</xref>).</p><p>The spectrum of activity of antimalarials, such as mefloquine or the artemisinins, was also assessed against echinococcosis. Mefloquine presented a dose dependent activity against metacestodes <italic>in vitro</italic>, although a reduction of the parasite weight in <italic>E. multilocularis</italic>-infected mice was only achieved by intraperitoneal mefloquine administration and not with oral treatments (<xref rid="b0665" ref-type="bibr">Kuster et al., 2011</xref>). Artesunate and dihydroartemisinin, however, had no effect against <italic>E. multilocularis in vivo</italic> (<xref rid="b0975" ref-type="bibr">Spicher et al., 2008</xref>), despite excellent <italic>in vitro</italic> activity. Furthermore, <italic>in vitro</italic> incubation of <italic>E. multilocularis</italic> larvae with artemether did not induce destruction of parasite vesicles (<xref rid="b0865" ref-type="bibr">Reuter et al., 2006</xref>).</p><p>Ethanol (70–95%), hypertonic saline (15–30%) and cetrimide solution (0.5%) are considered to be scolicidal agents for PAIR treatment with relatively low risk according to the <xref rid="b0065" ref-type="bibr">WHO (1996)</xref>. Efforts were made to discover more potent scolicidal agents to reduce the recurrence rate following PAIR and surgical interventions. For instance, chlorhexidine gluconate, which is a commonly available, inexpensive, and non-toxic antiseptic agent, proved to be highly active at a concentration of 0.04% following intracystic injection (<xref rid="b1040" ref-type="bibr">Topcu et al., 2009</xref>). Moreover, <italic>in vitro</italic> data confirm that intracystic albendazole sulfoxide injections at concentrations of 50–100 μg/ml are highly scolicidal and additional studies in rabbits indicate that this treatment lacks biliary and systemic toxicity (<xref rid="b0305 b0025" ref-type="bibr">Erzurumlu et al., 1998; Adas et al., 2009</xref>). Recently, a water-soluble albendazole sulfoxide salt was developed (Bayverm®-PI, Bayer HealthCare), which enabled the preparation of a liquid dosing form and henceforth systemic and even intracystic injections. Importantly, systemic application circumvents the low oral absorption rate of albendazole and significantly elevates drug disposition (<xref rid="b0670" ref-type="bibr">Lanusse et al., 1998</xref>). A proof of concept trial in sheep infected with <italic>E. granulosus</italic> (<italic>n</italic> = 7) was performed, which demonstrated that intracystic instillation without reaspiration of albendazole sulfoxide significantly decreased cyst size and lead to death of all protoscoleces and daughter cysts 6 months post-injection (<xref rid="b0255" ref-type="bibr">Deger et al., 2000</xref>). Further studies in animals and human subjects are warranted to evaluate if this therapeutic approach could substitute the current lengthy oral albendazole therapy.</p><p>Albendazole and mebendazole are currently the recommended drugs for chemotherapy of echinococcosis; hence it is reasonable that other benzimidazole derivatives are investigated. For instance flubendazole induced 90% reduction in cyst weight compared to untreated mice infected with <italic>E. granulosus</italic>. This is particularly remarkable, as lower quantities of flubendazole were detected in plasma and within the cysts compared to albendazole treatments, suggesting a higher potency of flubendazole (<xref rid="b0200" ref-type="bibr">Ceballos et al., 2011</xref>). Finally, it could be demonstrated that oxfendazole (60 mg/kg) alone and in combination with praziquantel was able to decrease protoscolex viability and reduce the diameter of liver and lung cysts in sheep naturally infected with <italic>E. granulosus</italic> following short-term treatment regimens (⩽6 weeks) (<xref rid="b0350" ref-type="bibr">Gavidia et al., 2010</xref>). Notably, triclabendazole has shown potency <italic>in vitro</italic> and it would be interesting to see if it is as successful as the other benzimidazoles <italic>in vivo</italic> (<xref rid="b0875" ref-type="bibr">Richter et al., 2013</xref>).</p></sec></sec></sec><sec sec-type="conclusions" id="s0155"><label>6</label><title>Conclusion</title><p>We have summarized drug repurposing efforts against a wide array of helminth infections. Drug repurposing is an important strategy, in particular for these neglected tropical diseases since drug discovery and development has languished in this field. Moreover, the time, effort and resources saved renders drug repurposing a smart and ethical choice, as it can result in faster and more affordable access to new medicines.</p><p>Several dozen compounds were identified by systematically searching the literature and presented in our review. This rather low number mirrors the challenges helminth drug discovery efforts still face. <italic>In vitro</italic> screens are often low throughput and cumbersome, as described for the <italic>T. muris</italic> assay (<xref rid="b1150" ref-type="bibr">Wimmersberger et al., 2013</xref>). Furthermore, we lack adequate animal models; prominent examples are the two most important human filarials <italic>O. volvulus</italic> and <italic>Wuchereria bancrofti</italic>, and the problematic <italic>L. loa.</italic> As such, it is currently not possible to test drugs on these species directly <italic>in vivo</italic> and most testing is conducted with infection models from analogous animal filariasis infections, such as <italic>O. ochengi</italic> in cattle (<xref rid="b0360" ref-type="bibr">Geary and Mackenzie, 2011</xref>).</p><p>Interestingly, only a few compound classes have been investigated and several compounds have been studied against different helminth species. Antimalarial and anticancer compounds were most widely studied, though most of the successful anthelmintic compounds still come from the antimalarial and veterinary fields. Though most repurposed drugs still come from veterinary anthelmintic R & D, gradually compounds from fields such as antiprotozoal and anticancer research are being increasingly investigated (<xref rid="f0005" ref-type="fig">Fig. 1</xref>). As mentioned in this review these drug classes were not randomly selected but rather based on biological features (flukes have the same blood-feeding characteristic as <italic>Plasmodium</italic> spp.) and possible drug targets (identification of select protein kinases as being essential to schistosome development) of these parasites. With the availability of genomes, e.g. <italic>B. malayi</italic> or the <italic>L. loa</italic> genome, it is the hope of many that compound libraries containing drugs’ known modes of action can be matched <italic>in silico</italic> against helminth-specific gene targets, therefore providing potential drug candidates. In addition, unsurprisingly the benzimidazole class of compounds has been studied extensively. However, given that there is known cross-resistance between the various benzimidazoles in animal health, it is worth highlighting that a good clinical candidate arising from this group would rather replace albendazole and mebendazole than serve as backup.</p><p>Overall, disappointingly few compounds have been pursued into clinical testing, which does little to alleviate the dry anthelmintic pipelines. A notable exception however is the trichuricidal drug oxantel pamoate.</p><p>As public–private partnerships continue to expand, new compounds and compound libraries have been made openly accessible. For example, recently the Medicines for Malaria Venture made available an open-source library consisting of 200 drug-like and 200 probe-like compounds, which was screened against <italic>S. mansoni in vitro</italic> and <italic>in vivo.</italic> Though the <italic>in vivo</italic> results were moderate at best, it did provide two potential new scaffolds to of interest: the N,N′-diarylurea and 2,3-dianilinoquinoxaline derivatives (<xref rid="b0450" ref-type="bibr">Ingram-Sieber et al., 2014</xref>). This is an example illustrating that closer collaborations between different research fields would be of great benefit in the field of drug discovery and development for helminth diseases. More of such collaborations are needed to take bench findings to the field and to turn field successes into affordable and useable medicines.</p></sec><sec id="s0180"><title>Conflict of interest</title><p>The authors state that they present no conflict of interest in writing this review.</p></sec></body><back><ref-list><title>References</title><ref id="b0005"><element-citation publication-type="journal" id="h0005"><person-group person-group-type="author"><name><surname>Abaza</surname><given-names>H.</given-names></name><name><surname>El-Zayadi</surname><given-names>A.R.</given-names></name><name><surname>Kabil</surname><given-names>S.M.</given-names></name><name><surname>Rizk</surname><given-names>H.</given-names></name></person-group><article-title>Nitazoxanide in the treatment of patients with intestinal protozoan and helminthic infections: a report on 546 patients in Egypt</article-title><source>Curr. Ther. Res.</source><volume>59</volume><year>1998</year><fpage>116</fpage><lpage>121</lpage></element-citation></ref><ref id="b0010"><element-citation publication-type="journal" id="h0010"><person-group person-group-type="author"><name><surname>Abdul-Ghani</surname><given-names>R.A.</given-names></name><name><surname>Loutfy</surname><given-names>N.</given-names></name><name><surname>Hassan</surname><given-names>A.</given-names></name></person-group><article-title>Myrrh and trematodoses in Egypt: an overview of safety, efficacy and effectiveness profiles</article-title><source>Parasitol. Int.</source><volume>58</volume><year>2009</year><fpage>210</fpage><lpage>214</lpage><pub-id pub-id-type="pmid">19446652</pub-id></element-citation></ref><ref id="b0015"><element-citation publication-type="journal" id="h0015"><person-group person-group-type="author"><name><surname>Abdulla</surname><given-names>M.H.</given-names></name><name><surname>Ruelas</surname><given-names>D.S.</given-names></name><name><surname>Wolff</surname><given-names>B.</given-names></name><name><surname>Snedecor</surname><given-names>J.</given-names></name><name><surname>Lim</surname><given-names>K.C.</given-names></name><name><surname>Xu</surname><given-names>F.</given-names></name><name><surname>Renslo</surname><given-names>A.R.</given-names></name><name><surname>Williams</surname><given-names>J.</given-names></name><name><surname>McKerrow</surname><given-names>J.H.</given-names></name><name><surname>Caffrey</surname><given-names>C.R.</given-names></name></person-group><article-title>Drug discovery for schistosomiasis: hit and lead compounds identified in a library of known drugs by medium-throughput phenotypic screening</article-title><source>PLoS Negl. Trop. Dis.</source><volume>3</volume><year>2009</year><fpage>e478</fpage><pub-id pub-id-type="pmid">19597541</pub-id></element-citation></ref><ref id="b0020"><element-citation publication-type="journal" id="h0020"><person-group person-group-type="author"><name><surname>Abo-Madyan</surname><given-names>A.A.</given-names></name><name><surname>Morsy</surname><given-names>T.A.</given-names></name><name><surname>Motawea</surname><given-names>S.M.</given-names></name><name><surname>Morsy</surname><given-names>A.T.</given-names></name></person-group><article-title>Clinical trial of Mirazid in treatment of human fascioliasis, Ezbet El-Bakly (Tamyia Center) Al-Fayoum Governorate</article-title><source>J. Egypt. Soc. Parasitol.</source><volume>34</volume><year>2004</year><fpage>807</fpage><lpage>818</lpage><pub-id pub-id-type="pmid">15587309</pub-id></element-citation></ref><ref id="b0025"><element-citation publication-type="journal" id="h0025"><person-group person-group-type="author"><name><surname>Adas</surname><given-names>G.</given-names></name><name><surname>Arikan</surname><given-names>S.</given-names></name><name><surname>Kemik</surname><given-names>O.</given-names></name><name><surname>Oner</surname><given-names>A.</given-names></name><name><surname>Sahip</surname><given-names>N.</given-names></name><name><surname>Karatepe</surname><given-names>O.</given-names></name></person-group><article-title>Use of albendazole sulfoxide, albendazole sulfone, and combined solutions as scolicidal agents on hydatid cysts (<italic>in vitro</italic> study)</article-title><source>World J. Gastroenterol.</source><volume>15</volume><year>2009</year><fpage>112</fpage><lpage>116</lpage><pub-id pub-id-type="pmid">19115476</pub-id></element-citation></ref><ref id="b0030"><element-citation publication-type="journal" id="h0030"><person-group person-group-type="author"><name><surname>Adenusi</surname><given-names>A.A.</given-names></name><name><surname>Oke</surname><given-names>A.O.</given-names></name><name><surname>Adenusi</surname><given-names>A.O.</given-names></name></person-group><article-title>Comparison of ivermectin and thiabendazole in the treatment of uncomplicated human <italic>Strongyloides stercoralis</italic> infection</article-title><source>Afr. J. Biotechnol.</source><volume>2</volume><year>2003</year><fpage>465</fpage><lpage>469</lpage></element-citation></ref><ref id="b0035"><element-citation publication-type="journal" id="h0035"><person-group person-group-type="author"><name><surname>Akaza</surname><given-names>H.</given-names></name></person-group><article-title>Combined androgen blockade for prostate cancer: review of efficacy, safety and cost-effectiveness</article-title><source>Cancer Sci.</source><volume>102</volume><year>2011</year><fpage>51</fpage><lpage>56</lpage><pub-id pub-id-type="pmid">21091846</pub-id></element-citation></ref><ref id="b0040"><element-citation publication-type="journal" id="h0040"><person-group person-group-type="author"><name><surname>Ali</surname><given-names>R.</given-names></name><name><surname>Ozkalemkas</surname><given-names>F.</given-names></name><name><surname>Ozkocaman</surname><given-names>V.</given-names></name><name><surname>Ozcelik</surname><given-names>T.</given-names></name><name><surname>Akalin</surname><given-names>H.</given-names></name><name><surname>Ozkan</surname><given-names>A.</given-names></name><name><surname>Altundal</surname><given-names>Y.</given-names></name><name><surname>Tunali</surname><given-names>A.</given-names></name></person-group><article-title>Hydatid disease in acute leukemia: effect of anticancer treatment on echinococcosis</article-title><source>Microbes Infect.</source><volume>7</volume><year>2005</year><fpage>1073</fpage><lpage>1076</lpage><pub-id pub-id-type="pmid">15996888</pub-id></element-citation></ref><ref id="b0045"><element-citation publication-type="journal" id="h0045"><person-group person-group-type="author"><name><surname>Allarakhia</surname><given-names>M.</given-names></name></person-group><article-title>Open-source approaches for the repurposing of existing or failed candidate drugs: learning from and applying the lessons across diseases</article-title><source>Drug Des. Dev. Ther.</source><volume>7</volume><year>2013</year><fpage>753</fpage><lpage>766</lpage></element-citation></ref><ref id="b0050"><element-citation publication-type="journal" id="h0050"><person-group person-group-type="author"><name><surname>Altreuther</surname><given-names>G.</given-names></name><name><surname>Radeloff</surname><given-names>I.</given-names></name><name><surname>LeSueur</surname><given-names>C.</given-names></name><name><surname>Schimmel</surname><given-names>A.</given-names></name><name><surname>Krieger</surname><given-names>K.J.</given-names></name></person-group><article-title>Field evaluation of the efficacy and safety of emodepside plus praziquantel tablets (Profender tablets for dogs) against naturally acquired nematode and cestode infections in dogs</article-title><source>Parasitol. Res.</source><volume>105</volume><issue>Suppl 1</issue><year>2009</year><fpage>S23</fpage><lpage>29</lpage><pub-id pub-id-type="pmid">19575222</pub-id></element-citation></ref><ref id="b0055"><element-citation publication-type="journal" id="h0055"><person-group person-group-type="author"><name><surname>Andrews</surname><given-names>K.T.</given-names></name><name><surname>Fisher</surname><given-names>G.</given-names></name><name><surname>Skinner-Adams</surname><given-names>T.S.</given-names></name></person-group><article-title>Drug repurposing and human parasitic protozoan diseases</article-title><source>Int. J. Parasitol. Drugs Drug. Resist.</source><volume>4</volume><year>2014</year><fpage>95</fpage><lpage>111</lpage><pub-id pub-id-type="pmid">25057459</pub-id></element-citation></ref><ref id="b0060"><element-citation publication-type="journal" id="h0060"><person-group person-group-type="author"><name><surname>Andrews</surname><given-names>P.</given-names></name><name><surname>Thomas</surname><given-names>H.</given-names></name><name><surname>Pohlke</surname><given-names>R.</given-names></name><name><surname>Seubert</surname><given-names>J.</given-names></name></person-group><article-title>Praziquantel</article-title><source>Med. Res. Rev.</source><volume>3</volume><year>1983</year><fpage>147</fpage><lpage>200</lpage><pub-id pub-id-type="pmid">6408323</pub-id></element-citation></ref><ref id="b0070"><element-citation publication-type="journal" id="h0070"><person-group person-group-type="author"><name><surname>Anonymous</surname></name></person-group><article-title>Global programme to eliminate lymphatic filariasis</article-title><source>Wkly Epidemiol. Rec.</source><volume>84</volume><year>2009</year><fpage>437</fpage><lpage>444</lpage><pub-id pub-id-type="pmid">19860021</pub-id></element-citation></ref><ref id="b0075"><element-citation publication-type="journal" id="h0075"><person-group person-group-type="author"><name><surname>Anonymous</surname></name></person-group><article-title>Soil-transmitted helminthiases: number of children treated in 2010</article-title><source>Wkly Epidemiol. Rec.</source><volume>87</volume><year>2012</year><fpage>225</fpage><lpage>232</lpage><pub-id pub-id-type="pmid">24340403</pub-id></element-citation></ref><ref id="b0080"><element-citation publication-type="journal" id="h0080"><person-group person-group-type="author"><name><surname>Anonymous</surname></name></person-group><article-title>Preventive chemotherapy: planning, requesting medicines, and reporting</article-title><source>Wkly Epidemiol. Rec.</source><volume>89</volume><year>2014</year><fpage>61</fpage><lpage>71</lpage><pub-id pub-id-type="pmid">24707511</pub-id></element-citation></ref><ref id="b0085"><element-citation publication-type="journal" id="h0085"><person-group person-group-type="author"><name><surname>Armson</surname><given-names>A.</given-names></name><name><surname>Cunningham</surname><given-names>G.A.</given-names></name><name><surname>Grubb</surname><given-names>W.B.</given-names></name><name><surname>Mendis</surname><given-names>A.H.</given-names></name></person-group><article-title>Murine strongyloidiasis: the effects of cyclosporin A and thiabendazole administered singly and in combination</article-title><source>Int. J. Parasitol.</source><volume>25</volume><year>1995</year><fpage>533</fpage><lpage>535</lpage><pub-id pub-id-type="pmid">7635630</pub-id></element-citation></ref><ref id="b0090"><element-citation publication-type="journal" id="h0090"><person-group person-group-type="author"><name><surname>Awadzi</surname><given-names>K.</given-names></name><name><surname>Schulz-Key</surname><given-names>H.</given-names></name><name><surname>Howells</surname><given-names>R.E.</given-names></name><name><surname>Haddock</surname><given-names>D.R.</given-names></name><name><surname>Gilles</surname><given-names>H.M.</given-names></name></person-group><article-title>The chemotherapy of onchocerciasis VIII Levamisole and its combination with the benzimidazoles</article-title><source>Ann. Trop. Med. Parasitol.</source><volume>76</volume><year>1982</year><fpage>459</fpage><lpage>473</lpage><pub-id pub-id-type="pmid">7149837</pub-id></element-citation></ref><ref id="b1310"><element-citation publication-type="journal" id="h1300"><person-group person-group-type="author"><name><surname>Awadzi</surname><given-names>K.</given-names></name><name><surname>Edwards</surname><given-names>G.</given-names></name><name><surname>Opoku</surname><given-names>N.O.</given-names></name><name><surname>Ardrey</surname><given-names>A.E.</given-names></name><name><surname>Favager</surname><given-names>S.</given-names></name><name><surname>Addy</surname><given-names>E.T.</given-names></name><name><surname>Attah</surname><given-names>S.K.</given-names></name><name><surname>Yamuah</surname><given-names>L.K.</given-names></name><name><surname>Quartey</surname><given-names>B.T.</given-names></name></person-group><article-title>The safety, tolerability and pharmacokinetics of levamisole alone, levamisole plus ivermectin, and levamisole plus albendazole, and their efficacy against <italic>Onchocerca volvulus</italic></article-title><source>Ann. Trop. Med. Parasitol.</source><volume>98</volume><year>2004</year><fpage>595</fpage><lpage>614</lpage><pub-id pub-id-type="pmid">15324466</pub-id></element-citation></ref><ref id="b0095"><element-citation publication-type="journal" id="h0095"><person-group person-group-type="author"><name><surname>Awadzi</surname><given-names>K.</given-names></name><name><surname>Opoku</surname><given-names>N.O.</given-names></name><name><surname>Attah</surname><given-names>S.K.</given-names></name><name><surname>Lazdins-Helds</surname><given-names>J.</given-names></name><name><surname>Kuesel</surname><given-names>A.C.</given-names></name></person-group><article-title>A randomized, single-ascending-dose, ivermectin-controlled, double-blind study of moxidectin on <italic>Onchocerca volvulus</italic> infection</article-title><source>PLoS Negl. Trop. Dis.</source><volume>8</volume><issue>6</issue><year>2014</year><fpage>e2953</fpage><pub-id pub-id-type="pmid">24968000</pub-id></element-citation></ref><ref id="b0100"><element-citation publication-type="journal" id="h0100"><person-group person-group-type="author"><name><surname>Awasthi</surname><given-names>A.</given-names></name><name><surname>Razzak</surname><given-names>M.</given-names></name><name><surname>Al-Kassas</surname><given-names>R.</given-names></name><name><surname>Harvey</surname><given-names>J.</given-names></name><name><surname>Garg</surname><given-names>S.</given-names></name></person-group><article-title>Analytical profile of moxidectin</article-title><source>Profiles of drug substances, excipients, and related methodology</source><volume>38</volume><year>2013</year><fpage>315</fpage><lpage>366</lpage></element-citation></ref><ref id="b0105"><element-citation publication-type="journal" id="h0105"><person-group person-group-type="author"><name><surname>Babalola</surname><given-names>O.E.</given-names></name></person-group><article-title>Ocular onchocerciasis: current management and future prospects</article-title><source>Clin. Ophthalmol.</source><volume>5</volume><year>2011</year><fpage>1479</fpage><lpage>1491</lpage><pub-id pub-id-type="pmid">22069350</pub-id></element-citation></ref><ref id="b0110"><element-citation publication-type="journal" id="h0110"><person-group person-group-type="author"><name><surname>Basra</surname><given-names>A.</given-names></name><name><surname>Mombo-Ngoma</surname><given-names>G.</given-names></name><name><surname>Melser</surname><given-names>M.C.</given-names></name><name><surname>Diop</surname><given-names>D.A.</given-names></name><name><surname>Wurbel</surname><given-names>H.</given-names></name><name><surname>Mackanga</surname><given-names>J.R.</given-names></name><name><surname>Furstenau</surname><given-names>M.</given-names></name><name><surname>Zoleko</surname><given-names>R.M.</given-names></name><name><surname>Adegnika</surname><given-names>A.A.</given-names></name><name><surname>Gonzalez</surname><given-names>R.</given-names></name><name><surname>Menendez</surname><given-names>C.</given-names></name><name><surname>Kremsner</surname><given-names>P.G.</given-names></name><name><surname>Ramharter</surname><given-names>M.</given-names></name></person-group><article-title>Efficacy of mefloquine intermittent preventive treatment in pregnancy against <italic>Schistosoma haematobium</italic> infection in Gabon: a nested randomized controlled assessor-blinded clinical trial</article-title><source>Clin. Infect. Dis.</source><volume>56</volume><year>2013</year><fpage>e68</fpage><lpage>75</lpage><pub-id pub-id-type="pmid">23175561</pub-id></element-citation></ref><ref id="b0115"><element-citation publication-type="journal" id="h0115"><person-group person-group-type="author"><name><surname>Bauer</surname><given-names>C.</given-names></name><name><surname>Conraths</surname><given-names>F.J.</given-names></name></person-group><article-title>Comparative efficacy of moxidectin and mebendazole against gastrointestinal nematodes in experimentally infected lambs</article-title><source>Vet. Rec.</source><volume>135</volume><year>1994</year><fpage>136</fpage><lpage>138</lpage><pub-id pub-id-type="pmid">7975106</pub-id></element-citation></ref><ref id="b0120"><element-citation publication-type="journal" id="h0120"><person-group person-group-type="author"><name><surname>Beckman</surname><given-names>S.</given-names></name><name><surname>Grevelding</surname><given-names>C.G.</given-names></name></person-group><article-title>Imatinib has a fatal impact on morphology, pairing stability and survival of adult <italic>Schistosoma mansoni in vitro</italic></article-title><source>Int. J. Parasitol.</source><volume>40</volume><year>2010</year><fpage>521</fpage><lpage>526</lpage><pub-id pub-id-type="pmid">20149792</pub-id></element-citation></ref><ref id="b0125"><element-citation publication-type="journal" id="h0125"><person-group person-group-type="author"><name><surname>Bisoffi</surname><given-names>Z.</given-names></name><name><surname>Buonfrate</surname><given-names>D.</given-names></name><name><surname>Angheben</surname><given-names>A.</given-names></name><name><surname>Boscolo</surname><given-names>M.</given-names></name><name><surname>Anselmi</surname><given-names>M.</given-names></name><name><surname>Marocco</surname><given-names>S.</given-names></name><name><surname>Monteiro</surname><given-names>G.</given-names></name><name><surname>Gobbo</surname><given-names>M.</given-names></name><name><surname>Bisoffi</surname><given-names>G.</given-names></name><name><surname>Gobbi</surname><given-names>F.</given-names></name></person-group><article-title>Randomized clinical trial on ivermectin versus thiabendazole for the treatment of strongyloidiasis</article-title><source>PLoS Negl. Trop. Dis.</source><volume>5</volume><year>2011</year><fpage>e1254</fpage><pub-id pub-id-type="pmid">21814588</pub-id></element-citation></ref><ref id="b0130"><element-citation publication-type="journal" id="h0130"><person-group person-group-type="author"><name><surname>Bisoffi</surname><given-names>Z.</given-names></name><name><surname>Buonfrate</surname><given-names>D.</given-names></name><name><surname>Montresor</surname><given-names>A.</given-names></name><name><surname>Requena-Mendez</surname><given-names>A.</given-names></name><name><surname>Munoz</surname><given-names>J.</given-names></name><name><surname>Krolewiecki</surname><given-names>A.J.</given-names></name><name><surname>Gotuzzo</surname><given-names>E.</given-names></name><name><surname>Mena</surname><given-names>M.A.</given-names></name><name><surname>Chiodini</surname><given-names>P.L.</given-names></name><name><surname>Anselmi</surname><given-names>M.</given-names></name><name><surname>Moreira</surname><given-names>J.</given-names></name><name><surname>Albonico</surname><given-names>M.</given-names></name></person-group><article-title><italic>Strongyloides stercoralis</italic>: a plea for action</article-title><source>PLoS Negl. Trop. Dis.</source><volume>7</volume><year>2013</year><fpage>e2214</fpage><pub-id pub-id-type="pmid">23675546</pub-id></element-citation></ref><ref id="b0135"><element-citation publication-type="journal" id="h0135"><person-group person-group-type="author"><name><surname>Blagburn</surname><given-names>B.L.</given-names></name><name><surname>Hendrix</surname><given-names>C.M.</given-names></name><name><surname>Lindsay</surname><given-names>D.S.</given-names></name><name><surname>Vaughan</surname><given-names>J.L.</given-names></name><name><surname>Hepler</surname><given-names>D.I.</given-names></name><name><surname>Wright</surname><given-names>J.C.</given-names></name></person-group><article-title>Efficacy of milbemycin oxime against naturally acquired or experimentally induced <italic>Ancylostoma</italic> spp. and <italic>Trichuris vulpis</italic> infections in dogs</article-title><source>Am. J. Vet. Res.</source><volume>53</volume><year>1992</year><fpage>513</fpage><lpage>516</lpage><pub-id pub-id-type="pmid">1586020</pub-id></element-citation></ref><ref id="b0140"><element-citation publication-type="journal" id="h0140"><person-group person-group-type="author"><name><surname>Botros</surname><given-names>S.S.</given-names></name><name><surname>El-Lakkany</surname><given-names>N.M.</given-names></name><name><surname>Badawy</surname><given-names>A.A.</given-names></name><name><surname>Mahmoud</surname><given-names>S.S.</given-names></name><name><surname>Ebeid</surname><given-names>F.A.</given-names></name><name><surname>Fenwick</surname><given-names>A.</given-names></name></person-group><article-title>Mirazid shows insignificant activity against ovine fascioliasis</article-title><source>Ann. Trop. Med. Parasitol.</source><volume>103</volume><year>2009</year><fpage>605</fpage><lpage>616</lpage><pub-id pub-id-type="pmid">19825282</pub-id></element-citation></ref><ref id="b1230"><element-citation publication-type="journal" id="h1230"><person-group person-group-type="author"><name><surname>Brennan</surname><given-names>G.P.</given-names></name><name><surname>Fairweather</surname><given-names>I.</given-names></name><name><surname>Trudgett</surname><given-names>A.</given-names></name><name><surname>Hoey</surname><given-names>E.</given-names></name><name><surname>McCoy</surname></name><name><surname>McConville</surname><given-names>M.</given-names></name><name><surname>Meaney</surname><given-names>M.</given-names></name><name><surname>Robinson</surname><given-names>M.</given-names></name><name><surname>McFerran</surname><given-names>N.</given-names></name><name><surname>Ryan</surname><given-names>L.</given-names></name><name><surname>Lanusse</surname><given-names>C.</given-names></name><name><surname>Mottier</surname><given-names>L.</given-names></name><name><surname>Alvarez</surname><given-names>L.</given-names></name><name><surname>Solana</surname><given-names>H.</given-names></name><name><surname>Virkel</surname><given-names>G.</given-names></name><name><surname>Brophy</surname><given-names>P.M.</given-names></name></person-group><article-title>Understanding triclabendazole resistance</article-title><source>Exp. Mol. Pathol.</source><volume>82</volume><year>2007</year><fpage>104</fpage><lpage>109</lpage><pub-id pub-id-type="pmid">17398281</pub-id></element-citation></ref><ref id="b0150"><element-citation publication-type="journal" id="h0150"><person-group person-group-type="author"><name><surname>Bruch</surname><given-names>K.</given-names></name><name><surname>Haas</surname><given-names>J.</given-names></name></person-group><article-title>Effectiveness of single doses of Fenbendazole Hoe 88I against <italic>Ascaris</italic>, hookworm and <italic>Trichuris</italic> in man</article-title><source>Ann. Trop. Med. Parasitol.</source><volume>70</volume><year>1976</year><fpage>205</fpage><lpage>211</lpage><pub-id pub-id-type="pmid">779682</pub-id></element-citation></ref><ref id="b0155"><element-citation publication-type="journal" id="h0155"><person-group person-group-type="author"><name><surname>Brunetti</surname><given-names>E.</given-names></name><name><surname>Kern</surname><given-names>P.</given-names></name><name><surname>Vuitton</surname><given-names>D.A.</given-names></name></person-group><article-title>Writing Panel for the WHO-IWGE. Expert consensus for the diagnosis and treatment of cystic and alveolar echinococcosis in humans</article-title><source>Acta Trop.</source><volume>114</volume><year>2010</year><fpage>1</fpage><lpage>16</lpage><pub-id pub-id-type="pmid">19931502</pub-id></element-citation></ref><ref id="b0160"><element-citation publication-type="journal" id="h0160"><person-group person-group-type="author"><name><surname>Brunetti</surname><given-names>E.</given-names></name><name><surname>White</surname><given-names>A.C.</given-names><suffix>Jr.</suffix></name></person-group><article-title>Cestode infestations: hydatid disease and cysticercosis</article-title><source>Infect. Dis. Clin. North Am.</source><volume>26</volume><year>2012</year><fpage>421</fpage><lpage>435</lpage><pub-id pub-id-type="pmid">22632647</pub-id></element-citation></ref><ref id="b0165"><element-citation publication-type="journal" id="h0165"><person-group person-group-type="author"><name><surname>Bueding</surname><given-names>E.</given-names></name><name><surname>Hawkins</surname><given-names>J.</given-names></name><name><surname>Cha</surname><given-names>Y.N.</given-names></name></person-group><article-title>Antischistosomal effects of cyclosporin A</article-title><source>Agents Actions</source><volume>11</volume><year>1981</year><fpage>380</fpage><lpage>383</lpage><pub-id pub-id-type="pmid">7282489</pub-id></element-citation></ref><ref id="b0170"><element-citation publication-type="journal" id="h0170"><person-group person-group-type="author"><name><surname>Bunnag</surname><given-names>D.</given-names></name><name><surname>Harinasuta</surname><given-names>T.</given-names></name><name><surname>Viravan</surname><given-names>C.</given-names></name><name><surname>Jarupakorn</surname><given-names>V.</given-names></name><name><surname>Chindanond</surname><given-names>D.</given-names></name><name><surname>Desakorn</surname><given-names>V.</given-names></name></person-group><article-title>Clinical trial of flubendazole on hookworm, <italic>Trichuris trichiura</italic> and <italic>Ascaris lumbricoides</italic> infections. Southeast Asian</article-title><source>J. Trop. Med. Public Health</source><volume>11</volume><year>1980</year><fpage>363</fpage><lpage>366</lpage></element-citation></ref><ref id="b0175"><element-citation publication-type="journal" id="h0175"><person-group person-group-type="author"><name><surname>Bygott</surname><given-names>J.M.</given-names></name><name><surname>Chiodini</surname><given-names>P.L.</given-names></name></person-group><article-title>Praziquantel: neglected drug? Ineffective treatment? Or therapeutic choice in cystic hydatid disease?</article-title><source>Acta Trop.</source><volume>111</volume><year>2009</year><fpage>95</fpage><lpage>101</lpage><pub-id pub-id-type="pmid">19375409</pub-id></element-citation></ref><ref id="b0180"><element-citation publication-type="journal" id="h0180"><person-group person-group-type="author"><name><surname>Caffrey</surname><given-names>C.R.</given-names></name></person-group><article-title>Chemotherapy of schistosomiasis: present and future</article-title><source>Curr. Opin. Chem. Biol.</source><volume>11</volume><year>2007</year><fpage>433</fpage><lpage>439</lpage><pub-id pub-id-type="pmid">17652008</pub-id></element-citation></ref><ref id="b0185"><element-citation publication-type="journal" id="h0185"><person-group person-group-type="author"><name><surname>Carpio</surname><given-names>A.</given-names></name></person-group><article-title>Neurocysticercosis: an update</article-title><source>Lancet Infect. Dis.</source><volume>2</volume><year>2002</year><fpage>751</fpage><lpage>762</lpage><pub-id pub-id-type="pmid">12467692</pub-id></element-citation></ref><ref id="b0190"><element-citation publication-type="journal" id="h0190"><person-group person-group-type="author"><name><surname>Catton</surname><given-names>D.G.</given-names></name><name><surname>Van Schalkwyk</surname><given-names>P.C.</given-names></name></person-group><article-title>The efficacy of two anthelmintics against ascarids and hookworms in naturally infected cats</article-title><source>Parasitol. Res.</source><volume>90</volume><issue>Suppl 3</issue><year>2003</year><fpage>S144</fpage><lpage>145</lpage><pub-id pub-id-type="pmid">12928884</pub-id></element-citation></ref><ref id="b0195"><element-citation publication-type="journal" id="h0195"><person-group person-group-type="author"><name><surname>Ceballos</surname><given-names>L.</given-names></name><name><surname>Elissondo</surname><given-names>M.</given-names></name><name><surname>Bruni</surname><given-names>S.S.</given-names></name><name><surname>Denegri</surname><given-names>G.</given-names></name><name><surname>Alvarez</surname><given-names>L.</given-names></name><name><surname>Lanusse</surname><given-names>C.</given-names></name></person-group><article-title>Flubendazole in cystic echinococcosis therapy: pharmaco-parasitological evaluation in mice</article-title><source>Parasitol. Int.</source><volume>58</volume><year>2009</year><fpage>354</fpage><lpage>358</lpage><pub-id pub-id-type="pmid">19628054</pub-id></element-citation></ref><ref id="b0200"><element-citation publication-type="journal" id="h0200"><person-group person-group-type="author"><name><surname>Ceballos</surname><given-names>L.</given-names></name><name><surname>Elissondo</surname><given-names>C.</given-names></name><name><surname>Sanchez Bruni</surname><given-names>S.</given-names></name><name><surname>Denegri</surname><given-names>G.</given-names></name><name><surname>Lanusse</surname><given-names>C.</given-names></name><name><surname>Alvarez</surname><given-names>L.</given-names></name></person-group><article-title>Comparative performances of flubendazole and albendazole in cystic echinococcosis: <italic>ex vivo</italic> activity, plasma/cyst disposition, and efficacy in infected mice</article-title><source>Antimicrob. Agents Chemother.</source><volume>55</volume><year>2011</year><fpage>5861</fpage><lpage>5867</lpage><pub-id pub-id-type="pmid">21930885</pub-id></element-citation></ref><ref id="b0205"><element-citation publication-type="journal" id="h0205"><person-group person-group-type="author"><name><surname>Ceballos</surname><given-names>L.</given-names></name><name><surname>Moreno</surname><given-names>L.</given-names></name><name><surname>Torrado</surname><given-names>J.J.</given-names></name><name><surname>Lanusse</surname><given-names>C.</given-names></name><name><surname>Alvarez</surname><given-names>L.</given-names></name></person-group><article-title>Exploring flubendazole formulations for use in sheep. Pharmacokinetic evaluation of a cyclodextrin-based solution</article-title><source>BMC Vet. Res.</source><volume>8</volume><year>2012</year><fpage>71</fpage><pub-id pub-id-type="pmid">22640491</pub-id></element-citation></ref><ref id="b0210"><element-citation publication-type="journal" id="h0210"><person-group person-group-type="author"><name><surname>Cobo</surname><given-names>F.</given-names></name><name><surname>Yarnoz</surname><given-names>C.</given-names></name><name><surname>Sesma</surname><given-names>B.</given-names></name><name><surname>Fraile</surname><given-names>P.</given-names></name><name><surname>Aizcorbe</surname><given-names>M.</given-names></name><name><surname>Trujillo</surname><given-names>R.</given-names></name><name><surname>Diaz-de-Liano</surname><given-names>A.</given-names></name><name><surname>Ciga</surname><given-names>M.A.</given-names></name></person-group><article-title>Albendazole plus praziquantel versus albendazole alone as a pre-operative treatment in intra-abdominal hydatisosis caused by <italic>Echinococcus granulosus</italic></article-title><source>Trop. Med. Int. Health</source><volume>3</volume><year>1998</year><fpage>462</fpage><lpage>466</lpage><pub-id pub-id-type="pmid">9657508</pub-id></element-citation></ref><ref id="b0215"><element-citation publication-type="journal" id="h0215"><person-group person-group-type="author"><name><surname>Cohen</surname><given-names>D.J.</given-names></name><name><surname>Loertscher</surname><given-names>R.</given-names></name><name><surname>Rubin</surname><given-names>M.F.</given-names></name><name><surname>Tilney</surname><given-names>N.L.</given-names></name><name><surname>Carpenter</surname><given-names>C.B.</given-names></name><name><surname>Strom</surname><given-names>T.B.</given-names></name></person-group><article-title>Cyclosporine: a new immunosuppressive agent for organ transplantation</article-title><source>Annals Intern. Med.</source><volume>101</volume><year>1984</year><fpage>667</fpage><lpage>682</lpage></element-citation></ref><ref id="b0220"><element-citation publication-type="journal" id="h0220"><person-group person-group-type="author"><name><surname>Coles</surname><given-names>G.C.</given-names></name><name><surname>Giordano-Fenton</surname><given-names>D.J.</given-names></name><name><surname>Tritschler</surname><given-names>J.P.</given-names><suffix>2nd</suffix></name></person-group><article-title>Efficacy of moxidectin against nematodes in naturally infected sheep</article-title><source>Vet. Rec.</source><volume>135</volume><year>1994</year><fpage>38</fpage><lpage>39</lpage><pub-id pub-id-type="pmid">7975073</pub-id></element-citation></ref><ref id="b0225"><element-citation publication-type="journal" id="h0225"><person-group person-group-type="author"><name><surname>Cotreau</surname><given-names>M.M.</given-names></name><name><surname>Warren</surname><given-names>S.</given-names></name><name><surname>Ryan</surname><given-names>J.L.</given-names></name><name><surname>Fleckenstein</surname><given-names>L.</given-names></name><name><surname>Vanapalli</surname><given-names>S.R.</given-names></name><name><surname>Brown</surname><given-names>K.R.</given-names></name><name><surname>Rock</surname><given-names>D.</given-names></name><name><surname>Chen</surname><given-names>C.Y.</given-names></name><name><surname>Schwertschlag</surname><given-names>U.S.</given-names></name></person-group><article-title>The antiparasitic moxidectin: safety, tolerability, and pharmacokinetics in humans</article-title><source>J. Clin. Pharmacol.</source><volume>43</volume><year>2003</year><fpage>1108</fpage><lpage>1115</lpage><pub-id pub-id-type="pmid">14517193</pub-id></element-citation></ref><ref id="b0230"><element-citation publication-type="journal" id="h0230"><person-group person-group-type="author"><name><surname>Coulibaly</surname><given-names>Y.I.</given-names></name><name><surname>Dembele</surname><given-names>B.</given-names></name><name><surname>Diallo</surname><given-names>A.A.</given-names></name><name><surname>Lipner</surname><given-names>E.M.</given-names></name><name><surname>Doumbia</surname><given-names>S.S.</given-names></name><name><surname>Coulibaly</surname><given-names>S.Y.</given-names></name><name><surname>Konate</surname><given-names>S.</given-names></name><name><surname>Diallo</surname><given-names>D.A.</given-names></name><name><surname>Yalcouye</surname><given-names>D.</given-names></name><name><surname>Kubofcik</surname><given-names>J.</given-names></name><name><surname>Doumbo</surname><given-names>O.K.</given-names></name><name><surname>Traore</surname><given-names>A.K.</given-names></name><name><surname>Keita</surname><given-names>A.D.</given-names></name><name><surname>Fay</surname><given-names>M.P.</given-names></name><name><surname>Traore</surname><given-names>S.F.</given-names></name><name><surname>Nutman</surname><given-names>T.B.</given-names></name><name><surname>Klion</surname><given-names>A.D.</given-names></name></person-group><article-title>A randomized trial of doxycycline for <italic>Mansonella perstans</italic> infection</article-title><source>New Eng. J. Med.</source><volume>361</volume><year>2009</year><fpage>1448</fpage><lpage>1458</lpage><pub-id pub-id-type="pmid">19812401</pub-id></element-citation></ref><ref id="b0235"><element-citation publication-type="journal" id="h0235"><person-group person-group-type="author"><name><surname>Davidson</surname><given-names>R.N.</given-names></name><name><surname>den Boer</surname><given-names>M.</given-names></name><name><surname>Ritmeijer</surname><given-names>K.</given-names></name></person-group><article-title>Paromomycin</article-title><source>Trans. R. Soc. Trop. Med. Hyg.</source><volume>103</volume><year>2009</year><fpage>653</fpage><lpage>660</lpage><pub-id pub-id-type="pmid">18947845</pub-id></element-citation></ref><ref id="b0240"><element-citation publication-type="journal" id="h0240"><person-group person-group-type="author"><name><surname>de Silva</surname><given-names>D.G.</given-names></name><name><surname>Lionel</surname><given-names>N.D.</given-names></name><name><surname>Jayatilleka</surname><given-names>S.M.</given-names></name></person-group><article-title>Flubendazole in the treatment of <italic>Ascaris lumbricoides</italic> and <italic>Trichuris trichiura</italic>: a comparison of two different regimens with single-dose</article-title><source>Ceylon Med. J.</source><volume>29</volume><year>1984</year><fpage>199</fpage><lpage>203</lpage><pub-id pub-id-type="pmid">6543679</pub-id></element-citation></ref><ref id="b0245"><element-citation publication-type="journal" id="h0245"><person-group person-group-type="author"><name><surname>Debrah</surname><given-names>A.Y.</given-names></name><name><surname>Mand</surname><given-names>S.</given-names></name><name><surname>Marfo-Debrekyei</surname><given-names>Y.</given-names></name><name><surname>Batsa</surname><given-names>L.</given-names></name><name><surname>Pfarr</surname><given-names>K.</given-names></name><name><surname>Buttner</surname><given-names>M.</given-names></name><name><surname>Adjei</surname><given-names>O.</given-names></name><name><surname>Buttner</surname><given-names>D.</given-names></name><name><surname>Hoerauf</surname><given-names>A.</given-names></name></person-group><article-title>Macrofilaricidal effect of 4 weeks of treatment with doxycycline on <italic>Wuchereria bancrofti</italic></article-title><source>Trop. Med. Int. Health</source><volume>12</volume><year>2007</year><fpage>1433</fpage><lpage>1441</lpage><pub-id pub-id-type="pmid">18076549</pub-id></element-citation></ref><ref id="b0250"><element-citation publication-type="journal" id="h0250"><person-group person-group-type="author"><name><surname>Debrah</surname><given-names>A.Y.</given-names></name><name><surname>Mand</surname><given-names>S.</given-names></name><name><surname>Marfo-Debrekyei</surname><given-names>Y.</given-names></name><name><surname>Batsa</surname><given-names>L.</given-names></name><name><surname>Pfarr</surname><given-names>K.</given-names></name><name><surname>Lawson</surname><given-names>B.</given-names></name><name><surname>Taylor</surname><given-names>M.</given-names></name><name><surname>Adjei</surname><given-names>O.</given-names></name><name><surname>Hoerauf</surname><given-names>A.</given-names></name></person-group><article-title>Reduction in levels of plasma vascular endothelial growth factor-A and improvement in hydrocele patients by targeting endosymbiotic <italic>Wolbachia</italic> sp. in <italic>Wuchereria bancroft</italic>i with doxycycline</article-title><source>Am. J. Trop. Med. Hyg.</source><volume>80</volume><year>2009</year><fpage>956</fpage><lpage>963</lpage><pub-id pub-id-type="pmid">19478258</pub-id></element-citation></ref><ref id="b0255"><element-citation publication-type="journal" id="h0255"><person-group person-group-type="author"><name><surname>Deger</surname><given-names>E.</given-names></name><name><surname>Hokelek</surname><given-names>M.</given-names></name><name><surname>Deger</surname><given-names>B.A.</given-names></name><name><surname>Tutar</surname><given-names>E.</given-names></name><name><surname>Asil</surname><given-names>M.</given-names></name><name><surname>Pakdemirli</surname><given-names>E.</given-names></name></person-group><article-title>A new therapeutic approach for the treatment of cystic echinococcosis: percutaneous albendazole sulphoxide injection without reaspiration</article-title><source>Am. J. Gastroenterol.</source><volume>95</volume><year>2000</year><fpage>248</fpage><lpage>254</lpage><pub-id pub-id-type="pmid">10638592</pub-id></element-citation></ref><ref id="b0260"><element-citation publication-type="journal" id="h0260"><person-group person-group-type="author"><name><surname>den Hollander</surname><given-names>P.</given-names></name><name><surname>Savage</surname><given-names>M.I.</given-names></name><name><surname>Brown</surname><given-names>P.H.</given-names></name></person-group><article-title>Targeted therapy for breast cancer prevention</article-title><source>Front. Oncol.</source><volume>3</volume><year>2013</year><fpage>250</fpage><pub-id pub-id-type="pmid">24069582</pub-id></element-citation></ref><ref id="b0265"><element-citation publication-type="journal" id="h0265"><person-group person-group-type="author"><name><surname>Diaz</surname><given-names>E.</given-names></name><name><surname>Mondragon</surname><given-names>J.</given-names></name><name><surname>Ramirez</surname><given-names>E.</given-names></name><name><surname>Bernal</surname><given-names>R.</given-names></name></person-group><article-title>Epidemiology and control of intestinal parasites with nitazoxanide in children in Mexico</article-title><source>Am. J. Trop. Med. Hyg.</source><volume>68</volume><year>2003</year><fpage>384</fpage><lpage>385</lpage><pub-id pub-id-type="pmid">12875284</pub-id></element-citation></ref><ref id="b0270"><element-citation publication-type="journal" id="h0270"><person-group person-group-type="author"><name><surname>Dissous</surname><given-names>C.</given-names></name><name><surname>Grevelding</surname><given-names>C.G.</given-names></name></person-group><article-title>Piggy-backing the concept of cancer drugs for schistosomiasis treatment: a tangible perspective?</article-title><source>Trends Parasitol.</source><volume>27</volume><year>2011</year><fpage>59</fpage><lpage>66</lpage><pub-id pub-id-type="pmid">20920890</pub-id></element-citation></ref><ref id="b0275"><element-citation publication-type="journal" id="h0275"><person-group person-group-type="author"><name><surname>Dominguez-Vazquez</surname><given-names>A.</given-names></name><name><surname>Taylor</surname><given-names>H.R.</given-names></name><name><surname>Greene</surname><given-names>B.M.</given-names></name><name><surname>Ruvalcaba-Macias</surname><given-names>A.M.</given-names></name><name><surname>Rivas-Alcala</surname><given-names>A.R.</given-names></name><name><surname>Murphy</surname><given-names>R.P.</given-names></name><name><surname>Beltran-Hernandez</surname><given-names>F.</given-names></name></person-group><article-title>Comparison of flubendazole and diethylcarbamazine in treatment of onchocerciasis</article-title><source>Lancet</source><volume>1</volume><year>1983</year><fpage>139</fpage><lpage>143</lpage><pub-id pub-id-type="pmid">6130195</pub-id></element-citation></ref><ref id="b0280"><element-citation publication-type="journal" id="h0280"><person-group person-group-type="author"><name><surname>Dorlo</surname><given-names>T.P.</given-names></name><name><surname>Balasegaram</surname><given-names>M.</given-names></name><name><surname>Beijnen</surname><given-names>J.H.</given-names></name><name><surname>de Vries</surname><given-names>P.J.</given-names></name></person-group><article-title>Miltefosine: a review of its pharmacology and therapeutic efficacy in the treatment of leishmaniasis</article-title><source>J. Antimicrob. Chemother.</source><volume>67</volume><year>2012</year><fpage>2576</fpage><lpage>2597</lpage><pub-id pub-id-type="pmid">22833634</pub-id></element-citation></ref><ref id="b0285"><element-citation publication-type="journal" id="h0285"><person-group person-group-type="author"><name><surname>Dreyer</surname><given-names>G.</given-names></name><name><surname>Addiss</surname><given-names>D.</given-names></name><name><surname>Williamson</surname><given-names>J.</given-names></name><name><surname>Noroes</surname><given-names>J.</given-names></name></person-group><article-title>Efficacy of co-administered diethylcarbamazine and albendazole against adult <italic>Wuchereria bancrofti</italic></article-title><source>Trans. R. Soc. Trop. Med. Hyg.</source><volume>100</volume><year>2006</year><fpage>1118</fpage><lpage>1125</lpage><pub-id pub-id-type="pmid">16860830</pub-id></element-citation></ref><ref id="b0290"><element-citation publication-type="journal" id="h0290"><person-group person-group-type="author"><name><surname>Eissa</surname><given-names>M.M.</given-names></name><name><surname>El-Azzouni</surname><given-names>M.Z.</given-names></name><name><surname>Amer</surname><given-names>E.I.</given-names></name><name><surname>Baddour</surname><given-names>N.M.</given-names></name></person-group><article-title>Miltefosine, a promising novel agent for schistosomiasis mansoni</article-title><source>Int. J. Parasitol.</source><volume>41</volume><year>2011</year><fpage>235</fpage><lpage>242</lpage><pub-id pub-id-type="pmid">21055404</pub-id></element-citation></ref><ref id="b0295"><element-citation publication-type="journal" id="h0295"><person-group person-group-type="author"><name><surname>Eissa</surname><given-names>M.M.</given-names></name><name><surname>El Bardicy</surname><given-names>S.</given-names></name><name><surname>Tadros</surname><given-names>M.</given-names></name></person-group><article-title>Bioactivity of miltefosine against aquatic stages of <italic>Schistosoma mansoni, Schistosoma haematobium</italic> and their snail hosts, supported by scanning electron microscopy</article-title><source>Parasite Vector</source><volume>4</volume><year>2011</year><fpage>73</fpage></element-citation></ref><ref id="b0300"><element-citation publication-type="journal" id="h0300"><person-group person-group-type="author"><name><surname>El Bialy</surname><given-names>S.A.</given-names></name><name><surname>Taman</surname><given-names>A.</given-names></name><name><surname>El-Beshbishi</surname><given-names>S.N.</given-names></name><name><surname>Mansour</surname><given-names>B.</given-names></name><name><surname>El-Malky</surname><given-names>M.</given-names></name><name><surname>Bayoumi</surname><given-names>W.A.</given-names></name><name><surname>Essa</surname><given-names>H.M.</given-names></name></person-group><article-title>Effect of a novel benzimidazole derivative in experimental <italic>Schistosoma mansoni</italic> infection</article-title><source>Parasitol. Res.</source><volume>112</volume><year>2013</year><fpage>4221</fpage><lpage>4229</lpage><pub-id pub-id-type="pmid">24096606</pub-id></element-citation></ref><ref id="b0305"><element-citation publication-type="journal" id="h0305"><person-group person-group-type="author"><name><surname>Erzurumlu</surname><given-names>K.</given-names></name><name><surname>Hokelek</surname><given-names>M.</given-names></name><name><surname>Baris</surname><given-names>S.</given-names></name><name><surname>Sahin</surname><given-names>M.</given-names></name><name><surname>Birinci</surname><given-names>A.</given-names></name><name><surname>Amanvermez</surname><given-names>R.</given-names></name><name><surname>Tac</surname><given-names>K.</given-names></name></person-group><article-title>Effect of albendazole sulfoxide solution on the scolices and the hepatobiliary system</article-title><source>Eur. Surg. Res.</source><volume>30</volume><year>1998</year><fpage>433</fpage><lpage>438</lpage><pub-id pub-id-type="pmid">9838237</pub-id></element-citation></ref><ref id="b0310"><element-citation publication-type="journal" id="h0310"><person-group person-group-type="author"><name><surname>Escobedo</surname><given-names>G.</given-names></name><name><surname>Palacios-Arreola</surname><given-names>M.I.</given-names></name><name><surname>Olivos</surname><given-names>A.</given-names></name><name><surname>Lopez-Griego</surname><given-names>L.</given-names></name><name><surname>Morales-Montor</surname><given-names>J.</given-names></name></person-group><article-title>Tamoxifen treatment in hamsters induces protection during taeniosis by <italic>Taenia solium</italic></article-title><source>BioMed Res. Int.</source><volume>2013</volume><year>2013</year><fpage>280496</fpage><pub-id pub-id-type="pmid">23509701</pub-id></element-citation></ref><ref id="b0315"><element-citation publication-type="journal" id="h0315"><person-group person-group-type="author"><name><surname>Favennec</surname><given-names>L.</given-names></name><name><surname>Jave Ortiz</surname><given-names>J.</given-names></name><name><surname>Gargala</surname><given-names>G.</given-names></name><name><surname>Lopez Chegne</surname><given-names>N.</given-names></name><name><surname>Ayoub</surname><given-names>A.</given-names></name><name><surname>Rossignol</surname><given-names>J.F.</given-names></name></person-group><article-title>Double-blind, randomized, placebo-controlled study of nitazoxanide in the treatment of fascioliasis in adults and children from northern Peru</article-title><source>Aliment. Pharmacol. Ther.</source><volume>17</volume><year>2003</year><fpage>265</fpage><lpage>270</lpage><pub-id pub-id-type="pmid">12534412</pub-id></element-citation></ref><ref id="b0320"><element-citation publication-type="journal" id="h0320"><person-group person-group-type="author"><name><surname>Franz</surname><given-names>M.</given-names></name><name><surname>Zahner</surname><given-names>H.</given-names></name><name><surname>Benten</surname><given-names>P.</given-names></name></person-group><article-title>Fine-structure alterations in female <italic>Brugia malayi</italic> and <italic>Litomosoides carinii</italic> after <italic>in vivo</italic> treatment with flubendazole</article-title><source>Parasitol. Res.</source><volume>76</volume><year>1990</year><fpage>401</fpage><lpage>405</lpage><pub-id pub-id-type="pmid">2352917</pub-id></element-citation></ref><ref id="b0325"><element-citation publication-type="journal" id="h0325"><person-group person-group-type="author"><name><surname>Fürst</surname><given-names>T.</given-names></name><name><surname>Duthaler</surname><given-names>U.</given-names></name><name><surname>Sripa</surname><given-names>B.</given-names></name><name><surname>Utzinger</surname><given-names>J.</given-names></name><name><surname>Keiser</surname><given-names>J.</given-names></name></person-group><article-title>Trematode infections: liver and lung flukes</article-title><source>Infect. Dis. Clin. North Am.</source><volume>26</volume><year>2012</year><fpage>399</fpage><lpage>419</lpage><pub-id pub-id-type="pmid">22632646</pub-id></element-citation></ref><ref id="b0330"><element-citation publication-type="journal" id="h0330"><person-group person-group-type="author"><name><surname>Gann</surname><given-names>P.H.</given-names></name><name><surname>Neva</surname><given-names>F.A.</given-names></name><name><surname>Gam</surname><given-names>A.A.</given-names></name></person-group><article-title>A randomized trial of single- and two-dose ivermectin versus thiabendazole for treatment of strongyloidiasis</article-title><source>J. Infect. Dis.</source><volume>169</volume><year>1994</year><fpage>1076</fpage><lpage>1079</lpage><pub-id pub-id-type="pmid">8169394</pub-id></element-citation></ref><ref id="b0335"><element-citation publication-type="journal" id="h0335"><person-group person-group-type="author"><name><surname>Garcia</surname><given-names>E.G.</given-names></name></person-group><article-title>Treatment for trichuriasis with oxantel</article-title><source>Am. J. Trop. Med. Hyg.</source><volume>25</volume><year>1976</year><fpage>914</fpage><lpage>915</lpage><pub-id pub-id-type="pmid">1008134</pub-id></element-citation></ref><ref id="b1235"><element-citation publication-type="journal" id="h1235"><person-group person-group-type="author"><name><surname>Garcia</surname><given-names>H.H.</given-names></name><name><surname>Lescano</surname><given-names>A.G.</given-names></name><name><surname>Lanchote</surname><given-names>V.L.</given-names></name><name><surname>Pretell</surname><given-names>E.J.</given-names></name><name><surname>Gonzales</surname><given-names>I.</given-names></name><name><surname>Bustos</surname><given-names>J.A.</given-names></name><name><surname>Takayanagui</surname><given-names>O.M.</given-names></name><name><surname>Bonato</surname><given-names>P.S.</given-names></name><name><surname>Horton</surname><given-names>J.</given-names></name><name><surname>Saavedra</surname><given-names>H.</given-names></name><name><surname>Gonzalez</surname><given-names>A.E.</given-names></name><name><surname>Gilman</surname><given-names>R.H.</given-names></name></person-group><article-title>Cysticercosis working group in Peru. Pharmacokinetics of combined treatment with praziquantel and albendazole in neurocysticercosis</article-title><source>Br. J. Clin. Pharmacol.</source><volume>72</volume><year>2011</year><fpage>77</fpage><lpage>84</lpage><pub-id pub-id-type="pmid">21332573</pub-id></element-citation></ref><ref id="b0345"><element-citation publication-type="journal" id="h0345"><person-group person-group-type="author"><name><surname>Gardner</surname><given-names>J.M.</given-names></name><name><surname>Grantham-McGregor</surname><given-names>S.</given-names></name><name><surname>Baddeley</surname><given-names>A.</given-names></name></person-group><article-title><italic>Trichuris trichiura</italic> infection and cognitive function in Jamaican school children</article-title><source>Ann. Trop. Med. Parasitol.</source><volume>90</volume><year>1996</year><fpage>55</fpage><lpage>63</lpage><pub-id pub-id-type="pmid">8729628</pub-id></element-citation></ref><ref id="b0350"><element-citation publication-type="journal" id="h0350"><person-group person-group-type="author"><name><surname>Gavidia</surname><given-names>C.M.</given-names></name><name><surname>Gonzalez</surname><given-names>A.E.</given-names></name><name><surname>Barron</surname><given-names>E.A.</given-names></name><name><surname>Ninaquispe</surname><given-names>B.</given-names></name><name><surname>Llamosas</surname><given-names>M.</given-names></name><name><surname>Verastegui</surname><given-names>M.R.</given-names></name><name><surname>Robinson</surname><given-names>C.</given-names></name><name><surname>Gilman</surname><given-names>R.H.</given-names></name></person-group><article-title>Evaluation of oxfendazole, praziquantel and albendazole against cystic echinococcosis: a randomized clinical trial in naturally infected sheep</article-title><source>PLoS Negl. Trop. Dis.</source><volume>4</volume><year>2010</year><fpage>e616</fpage><pub-id pub-id-type="pmid">20186332</pub-id></element-citation></ref><ref id="b0355"><element-citation publication-type="journal" id="h0355"><person-group person-group-type="author"><name><surname>Gayen</surname><given-names>P.</given-names></name><name><surname>Nayak</surname><given-names>A.</given-names></name><name><surname>Saini</surname><given-names>P.</given-names></name><name><surname>Mukherjee</surname><given-names>N.</given-names></name><name><surname>Maitra</surname><given-names>S.</given-names></name><name><surname>Sarkar</surname><given-names>P.</given-names></name><name><surname>Sinha Babu</surname><given-names>S.P.</given-names></name></person-group><article-title>A double-blind controlled field trial of doxycycline and albendazole in combination for the treatment of bancroftian filariasis in India</article-title><source>Acta Trop.</source><volume>125</volume><year>2013</year><fpage>150</fpage><lpage>156</lpage><pub-id pub-id-type="pmid">23123345</pub-id></element-citation></ref><ref id="b0360"><element-citation publication-type="journal" id="h0360"><person-group person-group-type="author"><name><surname>Geary</surname><given-names>T.G.</given-names></name><name><surname>Mackenzie</surname><given-names>C.D.</given-names></name></person-group><article-title>Progress and challenges in the discovery of macrofilaricidal drugs</article-title><source>Expert Rev. Anti Infect. Ther.</source><volume>9</volume><year>2011</year><fpage>681</fpage><lpage>695</lpage><pub-id pub-id-type="pmid">21819332</pub-id></element-citation></ref><ref id="b0365"><element-citation publication-type="journal" id="h0365"><person-group person-group-type="author"><name><surname>Greaves</surname><given-names>D.</given-names></name><name><surname>Coggle</surname><given-names>S.</given-names></name><name><surname>Pollard</surname><given-names>C.</given-names></name><name><surname>Aliyu</surname><given-names>S.H.</given-names></name><name><surname>Moore</surname><given-names>E.M.</given-names></name></person-group><article-title><italic>Strongyloides stercoralis</italic> infection</article-title><source>BMJ</source><volume>347</volume><year>2013</year><fpage>f4610</fpage><pub-id pub-id-type="pmid">23900531</pub-id></element-citation></ref><ref id="b0370"><element-citation publication-type="journal" id="h0370"><person-group person-group-type="author"><name><surname>Gryseels</surname><given-names>B.</given-names></name></person-group><article-title>Schistosomiasis</article-title><source>Infect. Dis. Clin. North Am.</source><volume>26</volume><year>2012</year><fpage>383</fpage><lpage>397</lpage><pub-id pub-id-type="pmid">22632645</pub-id></element-citation></ref><ref id="b0375"><element-citation publication-type="journal" id="h0375"><person-group person-group-type="author"><name><surname>Harder</surname><given-names>A.</given-names></name><name><surname>von Samson-Himmelstjerna</surname><given-names>G.</given-names></name></person-group><article-title>Cyclooctadepsipeptides – a new class of anthelmintically active compounds</article-title><source>Parasitol. Res.</source><volume>88</volume><year>2002</year><fpage>481</fpage><lpage>488</lpage><pub-id pub-id-type="pmid">12107468</pub-id></element-citation></ref><ref id="b0380"><element-citation publication-type="journal" id="h0380"><person-group person-group-type="author"><name><surname>Harder</surname><given-names>A.</given-names></name><name><surname>Schmitt-Wrede</surname><given-names>H.P.</given-names></name><name><surname>Krucken</surname><given-names>J.</given-names></name><name><surname>Marinovski</surname><given-names>P.</given-names></name><name><surname>Wunderlich</surname><given-names>F.</given-names></name><name><surname>Willson</surname><given-names>J.</given-names></name><name><surname>Amliwala</surname><given-names>K.</given-names></name><name><surname>Holden-Dye</surname><given-names>L.</given-names></name><name><surname>Walker</surname><given-names>R.</given-names></name></person-group><article-title>Cyclooctadepsipeptides–an anthelmintically active class of compounds exhibiting a novel mode of action</article-title><source>Int. J. Antimicrob. Agents</source><volume>22</volume><year>2003</year><fpage>318</fpage><lpage>331</lpage><pub-id pub-id-type="pmid">13678839</pub-id></element-citation></ref><ref id="b0385"><element-citation publication-type="journal" id="h0385"><person-group person-group-type="author"><name><surname>Hemphill</surname><given-names>A.</given-names></name><name><surname>Mueller</surname><given-names>J.</given-names></name><name><surname>Esposito</surname><given-names>M.</given-names></name></person-group><article-title>Nitazoxanide, a broad-spectrum thiazolide anti-infective agent for the treatment of gastrointestinal infections</article-title><source>Expert Opin. Pharmacother.</source><volume>7</volume><year>2006</year><fpage>953</fpage><lpage>964</lpage><pub-id pub-id-type="pmid">16634717</pub-id></element-citation></ref><ref id="b0390"><element-citation publication-type="journal" id="h0390"><person-group person-group-type="author"><name><surname>Hien</surname><given-names>T.T.</given-names></name><name><surname>Truong</surname><given-names>N.T.</given-names></name><name><surname>Minh</surname><given-names>N.H.</given-names></name><name><surname>Dat</surname><given-names>H.D.</given-names></name><name><surname>Dung</surname><given-names>N.T.</given-names></name><name><surname>Hue</surname><given-names>N.T.</given-names></name><name><surname>Dung</surname><given-names>T.K.</given-names></name><name><surname>Tuan</surname><given-names>P.Q.</given-names></name><name><surname>Campbell</surname><given-names>J.I.</given-names></name><name><surname>Farrar</surname><given-names>J.J.</given-names></name><name><surname>Day</surname><given-names>J.N.</given-names></name></person-group><article-title>A randomized controlled pilot study of artesunate versus triclabendazole for human fascioliasis in central Vietnam</article-title><source>Am. J. Trop. Med. Hyg.</source><volume>78</volume><year>2008</year><fpage>388</fpage><lpage>392</lpage><pub-id pub-id-type="pmid">18337331</pub-id></element-citation></ref><ref id="b0395"><element-citation publication-type="journal" id="h0395"><person-group person-group-type="author"><name><surname>Ho</surname><given-names>W.E.</given-names></name><name><surname>Peh</surname><given-names>H.Y.</given-names></name><name><surname>Chan</surname><given-names>T.K.</given-names></name><name><surname>Wong</surname><given-names>W.S.</given-names></name></person-group><article-title>Artemisinins: pharmacological actions beyond anti-malarial</article-title><source>Pharmacol. Ther.</source><volume>142</volume><year>2014</year><fpage>126</fpage><lpage>139</lpage><pub-id pub-id-type="pmid">24316259</pub-id></element-citation></ref><ref id="b0400"><element-citation publication-type="journal" id="h0400"><person-group person-group-type="author"><name><surname>Hoerauf</surname><given-names>A.</given-names></name><name><surname>Mand</surname><given-names>S.</given-names></name><name><surname>Volkmann</surname><given-names>L.</given-names></name><name><surname>Buttner</surname><given-names>M.</given-names></name><name><surname>Marfo-Debrekyei</surname><given-names>Y.</given-names></name><name><surname>Taylor</surname><given-names>M.</given-names></name><name><surname>Adjei</surname><given-names>O.</given-names></name><name><surname>Buttner</surname><given-names>D.W.</given-names></name></person-group><article-title>Doxycycline in the treatment of human onchocerciasis: kinetics of <italic>Wolbachia</italic> endobacteria reduction and of inhibition of embryogenesis in female <italic>Onchocerca</italic> worms</article-title><source>Microb. Infect.</source><volume>5</volume><year>2003</year><fpage>261</fpage><lpage>273</lpage></element-citation></ref><ref id="b0405"><element-citation publication-type="journal" id="h0405"><person-group person-group-type="author"><name><surname>Hoerauf</surname><given-names>A.</given-names></name><name><surname>Marfo-Debrekyei</surname><given-names>Y.</given-names></name><name><surname>Buttner</surname><given-names>M.</given-names></name><name><surname>Debrah</surname><given-names>A.Y.</given-names></name><name><surname>Konadu</surname><given-names>P.</given-names></name><name><surname>Mand</surname><given-names>S.</given-names></name><name><surname>Adjei</surname><given-names>O.</given-names></name><name><surname>Buttner</surname><given-names>D.W.</given-names></name></person-group><article-title>Effects of 6-week azithromycin treatment on the <italic>Wolbachia endobacteria</italic> of <italic>Onchocerca volvulus</italic></article-title><source>Parasitol. Res.</source><volume>103</volume><year>2008</year><fpage>279</fpage><lpage>286</lpage><pub-id pub-id-type="pmid">18421478</pub-id></element-citation></ref><ref id="b0410"><element-citation publication-type="journal" id="h0410"><person-group person-group-type="author"><name><surname>Hoerauf</surname><given-names>A.</given-names></name><name><surname>Specht</surname><given-names>S.</given-names></name><name><surname>Buttner</surname><given-names>M.</given-names></name><name><surname>Pfarr</surname><given-names>K.</given-names></name><name><surname>Mand</surname><given-names>S.</given-names></name><name><surname>Fimmers</surname><given-names>R.</given-names></name><name><surname>Marfo-Debrekyei</surname><given-names>Y.</given-names></name><name><surname>Konadu</surname><given-names>P.</given-names></name><name><surname>Debrah</surname><given-names>A.Y.</given-names></name><name><surname>Bandi</surname><given-names>C.</given-names></name><name><surname>Brattig</surname><given-names>N.</given-names></name><name><surname>Albers</surname><given-names>A.</given-names></name><name><surname>Larbi</surname><given-names>J.</given-names></name><name><surname>Batsa</surname><given-names>L.</given-names></name><name><surname>Taylor</surname><given-names>M.J.</given-names></name><name><surname>Adjei</surname><given-names>O.</given-names></name><name><surname>Buttner</surname><given-names>D.W.</given-names></name></person-group><article-title><italic>Wolbachia</italic> endobacteria depletion by doxycycline as antifilarial therapy has macrofilaricidal activity in onchocerciasis: a randomized placebo-controlled study</article-title><source>Med. Microbiol. Immunol.</source><volume>197</volume><year>2008</year><fpage>295</fpage><lpage>311</lpage><pub-id pub-id-type="pmid">17999080</pub-id></element-citation></ref><ref id="b0415"><element-citation publication-type="journal" id="h0415"><person-group person-group-type="author"><name><surname>Holmstedt</surname><given-names>B.</given-names></name><name><surname>Nordgren</surname><given-names>I.</given-names></name><name><surname>Sandoz</surname><given-names>M.</given-names></name><name><surname>Sundwall</surname><given-names>A.</given-names></name></person-group><article-title>Metrifonate. Summary of toxicological and pharmacological information available</article-title><source>Arch. Toxicol.</source><volume>41</volume><year>1978</year><fpage>3</fpage><lpage>29</lpage><pub-id pub-id-type="pmid">363095</pub-id></element-citation></ref><ref id="b0420"><element-citation publication-type="journal" id="h0420"><person-group person-group-type="author"><name><surname>Hotez</surname><given-names>P.J.</given-names></name><name><surname>Molyneux</surname><given-names>D.H.</given-names></name><name><surname>Fenwick</surname><given-names>A.</given-names></name><name><surname>Ottesen</surname><given-names>E.</given-names></name><name><surname>Ehrlich Sachs</surname><given-names>S.</given-names></name><name><surname>Sachs</surname><given-names>J.D.</given-names></name></person-group><article-title>Incorporating a rapid-impact package for neglected tropical diseases with programs for HIV/AIDS, tuberculosis, and malaria</article-title><source>PLoS Med.</source><volume>3</volume><year>2006</year><fpage>e102</fpage><pub-id pub-id-type="pmid">16435908</pub-id></element-citation></ref><ref id="b0425"><element-citation publication-type="journal" id="h0425"><person-group person-group-type="author"><name><surname>Huang</surname><given-names>Y.X.</given-names></name><name><surname>Zhou</surname><given-names>J.X.</given-names></name><name><surname>Xue</surname><given-names>Z.Q.</given-names></name><name><surname>Wu</surname><given-names>Y.X.</given-names></name><name><surname>Chen</surname><given-names>J.Y.</given-names></name><name><surname>Wu</surname><given-names>H.Z.</given-names></name><name><surname>Ji</surname><given-names>M.H.</given-names></name><name><surname>Shen</surname><given-names>Y.P.</given-names></name><name><surname>Cao</surname><given-names>G.Q.</given-names></name><name><surname>Wu</surname><given-names>Z.X.</given-names></name></person-group><article-title>Clinical observations on the treatment of hookworm, Ascaris and Trichuris infection with oxibendazole</article-title><source>Chin. J. Parasitol. Parasit. Dis.</source><volume>8</volume><year>1990</year><fpage>100</fpage><lpage>103</lpage></element-citation></ref><ref id="b0430"><element-citation publication-type="journal" id="h0430"><person-group person-group-type="author"><name><surname>Inaoka</surname><given-names>T.</given-names></name><name><surname>Nakao</surname><given-names>M.</given-names></name><name><surname>Ohnishi</surname><given-names>K.</given-names></name><name><surname>Kutsumi</surname><given-names>H.</given-names></name></person-group><article-title>Experimental therapy in Chinese hamsters and rats infected with larval <italic>Echinococcus multilocularis</italic> by using mebendazole, albendazole and ivermectin with brief review of chemotherapy of human multilocular echinococcosis</article-title><source>Hokkaido J Med Sci</source><volume>62</volume><year>1987</year><fpage>54</fpage><lpage>67</lpage><pub-id pub-id-type="pmid">3546045</pub-id></element-citation></ref><ref id="b0435"><element-citation publication-type="journal" id="h0435"><person-group person-group-type="author"><name><surname>Ingold</surname><given-names>K.</given-names></name><name><surname>Bigler</surname><given-names>P.</given-names></name><name><surname>Thormann</surname><given-names>W.</given-names></name><name><surname>Cavaliero</surname><given-names>T.</given-names></name><name><surname>Gottstein</surname><given-names>B.</given-names></name><name><surname>Hemphill</surname><given-names>A.</given-names></name></person-group><article-title>Efficacies of albendazole sulfoxide and albendazole sulfone against <italic>in vitro-</italic> cultivated <italic>Echinococcus multilocularis</italic> metacestodes</article-title><source>Antimicrob. Agents Chemother.</source><volume>43</volume><year>1999</year><fpage>1052</fpage><lpage>1061</lpage><pub-id pub-id-type="pmid">10223913</pub-id></element-citation></ref><ref id="b0440"><element-citation publication-type="journal" id="h0440"><person-group person-group-type="author"><name><surname>Ingram</surname><given-names>K.</given-names></name><name><surname>Ellis</surname><given-names>W.</given-names></name><name><surname>Keiser</surname><given-names>J.</given-names></name></person-group><article-title>Antischistosomal activities of mefloquine-related arylmethanols</article-title><source>Antimicrob. Agents Chemother.</source><volume>56</volume><year>2012</year><fpage>3207</fpage><lpage>3215</lpage><pub-id pub-id-type="pmid">22470113</pub-id></element-citation></ref><ref id="b0445"><element-citation publication-type="journal" id="h0445"><person-group person-group-type="author"><name><surname>Ingram</surname><given-names>K.</given-names></name><name><surname>Schiaffo</surname><given-names>C.E.</given-names></name><name><surname>Sittiwong</surname><given-names>W.</given-names></name><name><surname>Benner</surname><given-names>E.</given-names></name><name><surname>Dussault</surname><given-names>P.H.</given-names></name><name><surname>Keiser</surname><given-names>J.</given-names></name></person-group><article-title><italic>In vitro</italic> and <italic>in vivo</italic> activity of 3-alkoxy-1,2-dioxolanes against <italic>Schistosoma mansoni</italic></article-title><source>J. Antimicrob. Ther.</source><volume>67</volume><year>2012</year><fpage>1979</fpage><lpage>1986</lpage></element-citation></ref><ref id="b0450"><element-citation publication-type="journal" id="h0450"><person-group person-group-type="author"><name><surname>Ingram-Sieber</surname><given-names>K.</given-names></name><name><surname>Cowan</surname><given-names>N.</given-names></name><name><surname>Panic</surname><given-names>G.</given-names></name><name><surname>Vargas</surname><given-names>M.</given-names></name><name><surname>Mansour</surname><given-names>N.R.</given-names></name><name><surname>Bickle</surname><given-names>Q.D.</given-names></name><name><surname>Wells</surname><given-names>T.N.</given-names></name><name><surname>Spangenberg</surname><given-names>T.</given-names></name><name><surname>Keiser</surname><given-names>J.</given-names></name></person-group><article-title>Orally active antischistosomal early leads identified from the open access malaria box</article-title><source>PLoS Negl. Trop. Dis.</source><volume>8</volume><year>2014</year><fpage>e2610</fpage><pub-id pub-id-type="pmid">24416463</pub-id></element-citation></ref><ref id="b0455"><element-citation publication-type="journal" id="h0455"><person-group person-group-type="author"><name><surname>Jones</surname><given-names>R.M.</given-names></name><name><surname>Logan</surname><given-names>N.B.</given-names></name><name><surname>Weatherley</surname><given-names>A.J.</given-names></name><name><surname>Little</surname><given-names>A.S.</given-names></name><name><surname>Smothers</surname><given-names>C.D.</given-names></name></person-group><article-title>Activity of doramectin against nematode endoparasites of cattle</article-title><source>Vet. Parasitol.</source><volume>49</volume><year>1993</year><fpage>27</fpage><lpage>37</lpage><pub-id pub-id-type="pmid">8236735</pub-id></element-citation></ref><ref id="b0460"><element-citation publication-type="journal" id="h0460"><person-group person-group-type="author"><name><surname>Juan</surname><given-names>J.O.</given-names></name><name><surname>Lopez Chegne</surname><given-names>N.</given-names></name><name><surname>Gargala</surname><given-names>G.</given-names></name><name><surname>Favennec</surname><given-names>L.</given-names></name></person-group><article-title>Comparative clinical studies of nitazoxanide, albendazole and praziquantel in the treatment of ascariasis, trichuriasis and hymenolepiasis in children from Peru</article-title><source>Trans. R. Soc. Trop. Med. Hyg.</source><volume>96</volume><year>2002</year><fpage>193</fpage><lpage>196</lpage><pub-id pub-id-type="pmid">12055813</pub-id></element-citation></ref><ref id="b0465"><element-citation publication-type="journal" id="h0465"><person-group person-group-type="author"><name><surname>Kamgno</surname><given-names>J.</given-names></name><name><surname>Pion</surname><given-names>S.D.</given-names></name><name><surname>Tejiokem</surname><given-names>M.C.</given-names></name><name><surname>Twum-Danso</surname><given-names>N.A.</given-names></name><name><surname>Thylefors</surname><given-names>B.</given-names></name><name><surname>Boussinesq</surname><given-names>M.</given-names></name></person-group><article-title>Randomized, controlled, double-blind trial with ivermectin on <italic>Loa loa</italic> microfilaraemia: efficacy of a low dose (approximately 25 microg/kg) versus current standard dose (150 microg/kg)</article-title><source>Trans. R. Soc. Trop. Med. Hyg.</source><volume>101</volume><year>2007</year><fpage>777</fpage><lpage>785</lpage><pub-id pub-id-type="pmid">17531279</pub-id></element-citation></ref><ref id="b0470"><element-citation publication-type="journal" id="h0470"><person-group person-group-type="author"><name><surname>Kamgno</surname><given-names>J.</given-names></name><name><surname>Djomo</surname><given-names>P.N.</given-names></name><name><surname>Pion</surname><given-names>S.D.</given-names></name><name><surname>Thylefors</surname><given-names>B.</given-names></name><name><surname>Boussinesq</surname><given-names>M.</given-names></name></person-group><article-title>A controlled trial to assess the effect of quinine, chloroquine, amodiaquine, and artesunate on <italic>Loa loa</italic> microfilaremia</article-title><source>Am. J. Trop. Med. Hyg.</source><volume>82</volume><year>2010</year><fpage>379</fpage><lpage>385</lpage><pub-id pub-id-type="pmid">20207860</pub-id></element-citation></ref><ref id="b0475"><element-citation publication-type="journal" id="h0475"><person-group person-group-type="author"><name><surname>Kan</surname><given-names>S.P.</given-names></name></person-group><article-title>The anthelmintic effects of flubendazole on <italic>Trichuris trichiura</italic> and <italic>Ascaris lumbricoides</italic></article-title><source>Trans. R. Soc. Trop. Med. Hyg.</source><volume>77</volume><year>1983</year><fpage>668</fpage><lpage>670</lpage><pub-id pub-id-type="pmid">6659046</pub-id></element-citation></ref><ref id="b0480"><element-citation publication-type="journal" id="h0480"><person-group person-group-type="author"><name><surname>Katiyar</surname><given-names>D.</given-names></name><name><surname>Singh</surname><given-names>L.K.</given-names></name></person-group><article-title>Filariasis: current status, treatment and recent advances in drug development</article-title><source>Curr. Med. Chem.</source><volume>18</volume><year>2011</year><fpage>2174</fpage><lpage>2185</lpage><pub-id pub-id-type="pmid">21521163</pub-id></element-citation></ref><ref id="b0485"><element-citation publication-type="journal" id="h0485"><person-group person-group-type="author"><name><surname>Katz</surname><given-names>N.</given-names></name><name><surname>Couto</surname><given-names>F.F.</given-names></name><name><surname>Araujo</surname><given-names>N.</given-names></name></person-group><article-title>Imatinib activity on <italic>Schistosoma mansoni</italic></article-title><source>Mem. Inst. Oswaldo Cruz</source><volume>108</volume><year>2013</year><fpage>850</fpage><lpage>853</lpage><pub-id pub-id-type="pmid">24037106</pub-id></element-citation></ref><ref id="b0490"><element-citation publication-type="journal" id="h0490"><person-group person-group-type="author"><name><surname>Keiser</surname><given-names>J.</given-names></name><name><surname>Utzinger</surname><given-names>J.</given-names></name></person-group><article-title>Chemotherapy for major food-borne trematodes: a review</article-title><source>Expert Opin. Pharmacother.</source><volume>5</volume><year>2004</year><fpage>1711</fpage><lpage>1726</lpage><pub-id pub-id-type="pmid">15264986</pub-id></element-citation></ref><ref id="b0495"><element-citation publication-type="journal" id="h0495"><person-group person-group-type="author"><name><surname>Keiser</surname><given-names>J.</given-names></name><name><surname>Utzinger</surname><given-names>J.</given-names></name></person-group><article-title>Advances in the discovery and development of novel trematocidal drugs</article-title><source>Expert Opin. Drug Discov.</source><volume>2</volume><year>2007</year><fpage>9</fpage><lpage>23</lpage></element-citation></ref><ref id="b0500"><element-citation publication-type="journal" id="h0500"><person-group person-group-type="author"><name><surname>Keiser</surname><given-names>J.</given-names></name><name><surname>Utzinger</surname><given-names>J.</given-names></name></person-group><article-title>Artemisinins and synthetic trioxolanes in the treatment of helminth infections</article-title><source>Curr. Opin. Infect. Dis.</source><volume>20</volume><year>2007</year><fpage>605</fpage><lpage>612</lpage><pub-id pub-id-type="pmid">17975411</pub-id></element-citation></ref><ref id="b0505"><element-citation publication-type="journal" id="h0505"><person-group person-group-type="author"><name><surname>Keiser</surname><given-names>J.</given-names></name><name><surname>Utzinger</surname><given-names>J.</given-names></name></person-group><article-title>Food-borne trematodiasis: current chemotherapy and advances with artemisinins and synthetic trioxolanes</article-title><source>Trends Parasitol.</source><volume>23</volume><year>2007</year><fpage>555</fpage><lpage>562</lpage><pub-id pub-id-type="pmid">17950667</pub-id></element-citation></ref><ref id="b0510"><element-citation publication-type="journal" id="h0510"><person-group person-group-type="author"><name><surname>Keiser</surname><given-names>J.</given-names></name><name><surname>Utzinger</surname><given-names>J.</given-names></name></person-group><article-title>Efficacy of current drugs against soil-transmitted helminth infections: systematic review and meta-analysis</article-title><source>JAMA</source><volume>299</volume><year>2008</year><fpage>1937</fpage><lpage>1948</lpage><pub-id pub-id-type="pmid">18430913</pub-id></element-citation></ref><ref id="b0515"><element-citation publication-type="journal" id="h0515"><person-group person-group-type="author"><name><surname>Keiser</surname><given-names>J.</given-names></name><name><surname>Utzinger</surname><given-names>J.</given-names></name></person-group><article-title>The drugs we have and the drugs we need against major helminth infections</article-title><source>Adv. Parasitol.</source><volume>73</volume><year>2010</year><fpage>197</fpage><lpage>230</lpage><pub-id pub-id-type="pmid">20627144</pub-id></element-citation></ref><ref id="b0520"><element-citation publication-type="journal" id="h0520"><person-group person-group-type="author"><name><surname>Keiser</surname><given-names>J.</given-names></name><name><surname>Utzinger</surname><given-names>J.</given-names></name></person-group><article-title>Antimalarials in the treatment of schistosomiasis</article-title><source>Curr. Pharm. Des.</source><volume>18</volume><year>2012</year><fpage>3531</fpage><lpage>3538</lpage><pub-id pub-id-type="pmid">22607145</pub-id></element-citation></ref><ref id="b0525"><element-citation publication-type="journal" id="h0525"><person-group person-group-type="author"><name><surname>Keiser</surname><given-names>J.</given-names></name><name><surname>Engels</surname><given-names>D.</given-names></name><name><surname>Büscher</surname><given-names>G.</given-names></name><name><surname>Utzinger</surname><given-names>J.</given-names></name></person-group><article-title>Triclabendazole for the treatment of fascioliasis and paragonimiasis</article-title><source>Expert Opin. Investig. Drugs</source><volume>14</volume><year>2005</year><fpage>1513</fpage><lpage>1526</lpage></element-citation></ref><ref id="b0530"><element-citation publication-type="journal" id="h0530"><person-group person-group-type="author"><name><surname>Keiser</surname><given-names>J.</given-names></name><name><surname>Brun</surname><given-names>R.</given-names></name><name><surname>Fried</surname><given-names>B.</given-names></name><name><surname>Utzinger</surname><given-names>J.</given-names></name></person-group><article-title>Trematocidal activity of praziquantel and artemisinin derivatives: <italic>in vitro</italic> and <italic>in vivo</italic> investigations with adult <italic>Echinostoma caproni</italic></article-title><source>Antimicrob. Agents Chemother.</source><volume>50</volume><year>2006</year><fpage>803</fpage><lpage>805</lpage><pub-id pub-id-type="pmid">16436751</pub-id></element-citation></ref><ref id="b0535"><element-citation publication-type="journal" id="h0535"><person-group person-group-type="author"><name><surname>Keiser</surname><given-names>J.</given-names></name><name><surname>Utzinger</surname><given-names>J.</given-names></name><name><surname>Tanner</surname><given-names>M.</given-names></name><name><surname>Dong</surname><given-names>Y.</given-names></name><name><surname>Vennerstrom</surname><given-names>J.L.</given-names></name></person-group><article-title>The synthetic peroxide OZ78 is effective against <italic>Echinostoma caproni</italic> and <italic>Fasciola hepatica</italic></article-title><source>J. Antimicrob. Chemother.</source><volume>58</volume><year>2006</year><fpage>1193</fpage><lpage>1197</lpage><pub-id pub-id-type="pmid">17028093</pub-id></element-citation></ref><ref id="b0540"><element-citation publication-type="journal" id="h0540"><person-group person-group-type="author"><name><surname>Keiser</surname><given-names>J.</given-names></name><name><surname>Xiao</surname><given-names>S.H.</given-names></name><name><surname>Tanner</surname><given-names>M.</given-names></name><name><surname>Utzinger</surname><given-names>J.</given-names></name></person-group><article-title>Artesunate and artemether are effective fasciolicides in the rat model and <italic>in vitro</italic></article-title><source>J. Antimicrob. Chemother.</source><volume>57</volume><year>2006</year><fpage>1139</fpage><lpage>1145</lpage><pub-id pub-id-type="pmid">16581915</pub-id></element-citation></ref><ref id="b0545"><element-citation publication-type="journal" id="h0545"><person-group person-group-type="author"><name><surname>Keiser</surname><given-names>J.</given-names></name><name><surname>Xiao</surname><given-names>S.H.</given-names></name><name><surname>Xue</surname><given-names>J.</given-names></name><name><surname>Chan</surname><given-names>Z.S.</given-names></name><name><surname>Odermatt</surname><given-names>P.</given-names></name><name><surname>Tesana</surname><given-names>S.</given-names></name><name><surname>Tanner</surname><given-names>M.</given-names></name><name><surname>Utzinger</surname><given-names>J.</given-names></name></person-group><article-title>Effect of artesunate and artemether against <italic>Clonorchis sinensis</italic> and <italic>Opisthorchis viverrini</italic> in rodent models</article-title><source>Int. J. Antimicrob. Agents</source><volume>28</volume><year>2006</year><fpage>370</fpage><lpage>373</lpage><pub-id pub-id-type="pmid">16973335</pub-id></element-citation></ref><ref id="b0550"><element-citation publication-type="journal" id="h0550"><person-group person-group-type="author"><name><surname>Keiser</surname><given-names>J.</given-names></name><name><surname>Utzinger</surname><given-names>J.</given-names></name><name><surname>Vennerstrom</surname><given-names>J.L.</given-names></name><name><surname>Dong</surname><given-names>Y.</given-names></name><name><surname>Brennan</surname><given-names>G.</given-names></name><name><surname>Fairweather</surname><given-names>I.</given-names></name></person-group><article-title>Activity of artemether and OZ78 against triclabendazole-resistant <italic>Fasciola hepatica</italic></article-title><source>Trans. R. Soc. Trop. Med. Hyg.</source><volume>101</volume><year>2007</year><fpage>1219</fpage><lpage>1222</lpage><pub-id pub-id-type="pmid">17905370</pub-id></element-citation></ref><ref id="b0555"><element-citation publication-type="journal" id="h0555"><person-group person-group-type="author"><name><surname>Keiser</surname><given-names>J.</given-names></name><name><surname>Xiao</surname><given-names>S.H.</given-names></name><name><surname>Chollet</surname><given-names>J.</given-names></name><name><surname>Tanner</surname><given-names>M.</given-names></name><name><surname>Utzinger</surname><given-names>J.</given-names></name></person-group><article-title>Evaluation of the <italic>in vivo</italic> activity of tribendimidine against <italic>Schistosoma mansoni</italic>, <italic>Fasciola hepatica</italic>, <italic>Clonorchis sinensis</italic>, and <italic>Opisthorchis viverrini</italic></article-title><source>Antimicrob. Agents Chemother.</source><volume>51</volume><year>2007</year><fpage>1096</fpage><lpage>1098</lpage><pub-id pub-id-type="pmid">17194822</pub-id></element-citation></ref><ref id="b0560"><element-citation publication-type="journal" id="h0560"><person-group person-group-type="author"><name><surname>Keiser</surname><given-names>J.</given-names></name><name><surname>Rinaldi</surname><given-names>L.</given-names></name><name><surname>Veneziano</surname><given-names>V.</given-names></name><name><surname>Mezzino</surname><given-names>L.</given-names></name><name><surname>Tanner</surname><given-names>M.</given-names></name><name><surname>Utzinger</surname><given-names>J.</given-names></name><name><surname>Cringoli</surname><given-names>G.</given-names></name></person-group><article-title>Efficacy and safety of artemether against a natural <italic>Fasciola hepatica</italic> infection in sheep</article-title><source>Parasitol. Res.</source><volume>103</volume><year>2008</year><fpage>517</fpage><lpage>522</lpage><pub-id pub-id-type="pmid">18481085</pub-id></element-citation></ref><ref id="b1240"><element-citation publication-type="journal" id="h1240"><person-group person-group-type="author"><name><surname>Keiser</surname><given-names>J.</given-names></name><name><surname>Thiemann</surname><given-names>K.</given-names></name><name><surname>Endriss</surname><given-names>Y.</given-names></name><name><surname>Utzinger</surname><given-names>J.</given-names></name></person-group><article-title><italic>Strongyloides ratti</italic>: <italic>in vitro</italic> and <italic>in vivo</italic> activity of tribendimidine</article-title><source>PLoS Negl. Trop. Dis.</source><year>2008</year><fpage>e201</fpage><pub-id pub-id-type="pmid">18301728</pub-id></element-citation></ref><ref id="b0570"><element-citation publication-type="journal" id="h0570"><person-group person-group-type="author"><name><surname>Keiser</surname><given-names>J.</given-names></name><name><surname>Odermatt</surname><given-names>P.</given-names></name><name><surname>Tesana</surname><given-names>S.</given-names></name></person-group><article-title>Dose-response relationships and tegumental surface alterations in <italic>Opisthorchis viverrini</italic> following treatment with mefloquine <italic>in vivo</italic> and <italic>in vitro</italic></article-title><source>Parasitol. Res.</source><volume>105</volume><year>2009</year><fpage>261</fpage><lpage>266</lpage><pub-id pub-id-type="pmid">19308455</pub-id></element-citation></ref><ref id="b0575"><element-citation publication-type="journal" id="h0575"><person-group person-group-type="author"><name><surname>Keiser</surname><given-names>J.</given-names></name><name><surname>Xiao</surname><given-names>S.H.</given-names></name><name><surname>Smith</surname><given-names>T.A.</given-names></name><name><surname>Utzinger</surname><given-names>J.</given-names></name></person-group><article-title>Combination chemotherapy against <italic>Clonorchis sinensis</italic>: experiments with artemether, artesunate, OZ78, praziquantel, and tribendimidine in a rat model</article-title><source>Antimicrob. Agents Chemother.</source><volume>53</volume><year>2009</year><fpage>3770</fpage><lpage>3776</lpage><pub-id pub-id-type="pmid">19581454</pub-id></element-citation></ref><ref id="b0580"><element-citation publication-type="journal" id="h0580"><person-group person-group-type="author"><name><surname>Keiser</surname><given-names>J.</given-names></name><name><surname>Duthaler</surname><given-names>U.</given-names></name><name><surname>Utzinger</surname><given-names>J.</given-names></name></person-group><article-title>Update on the diagnosis and treatment of food-borne trematode infections</article-title><source>Curr. Opin. Infect. Dis.</source><volume>23</volume><year>2010</year><fpage>513</fpage><lpage>520</lpage><pub-id pub-id-type="pmid">20683264</pub-id></element-citation></ref><ref id="b0585"><element-citation publication-type="journal" id="h0585"><person-group person-group-type="author"><name><surname>Keiser</surname><given-names>J.</given-names></name><name><surname>Kirchhofer</surname><given-names>C.</given-names></name><name><surname>Haschke</surname><given-names>M.</given-names></name><name><surname>Huwyler</surname><given-names>J.</given-names></name><name><surname>Dong</surname><given-names>Y.</given-names></name><name><surname>Vennerstrom</surname><given-names>J.L.</given-names></name><name><surname>Vanhoff</surname><given-names>K.</given-names></name><name><surname>Kaminsky</surname><given-names>R.</given-names></name><name><surname>Malikides</surname><given-names>N.</given-names></name></person-group><article-title>Efficacy, safety and pharmacokinetics of 1,2,4-trioxolane OZ78 against an experimental infection with <italic>Fasciola hepatica</italic> in sheep</article-title><source>Vet. Parasitol.</source><volume>173</volume><year>2010</year><fpage>228</fpage><lpage>235</lpage><pub-id pub-id-type="pmid">20674178</pub-id></element-citation></ref><ref id="b0590"><element-citation publication-type="journal" id="h0590"><person-group person-group-type="author"><name><surname>Keiser</surname><given-names>J.</given-names></name><name><surname>N’Guessan</surname><given-names>N.A.</given-names></name><name><surname>Adoubryn</surname><given-names>K.D.</given-names></name><name><surname>Silue</surname><given-names>K.D.</given-names></name><name><surname>Vounatsou</surname><given-names>P.</given-names></name><name><surname>Hatz</surname><given-names>C.</given-names></name><name><surname>Utzinger</surname><given-names>J.</given-names></name><name><surname>N’Goran</surname><given-names>E.K.</given-names></name></person-group><article-title>Efficacy and safety of mefloquine, artesunate, mefloquine-artesunate, and praziquantel against <italic>Schistosoma haematobium</italic>: randomized, exploratory open-label trial</article-title><source>Clin. Infect. Dis.</source><volume>50</volume><year>2010</year><fpage>1205</fpage><lpage>1213</lpage><pub-id pub-id-type="pmid">20350194</pub-id></element-citation></ref><ref id="b0595"><element-citation publication-type="journal" id="h0595"><person-group person-group-type="author"><name><surname>Keiser</surname><given-names>J.</given-names></name><name><surname>Vargas</surname><given-names>M.</given-names></name><name><surname>Vennerstrom</surname><given-names>J.L.</given-names></name></person-group><article-title>Activity of antiandrogens against juvenile and adult <italic>Schistosoma mansoni</italic> in mice</article-title><source>J. Antimicrob. Chemother.</source><volume>65</volume><year>2010</year><fpage>1991</fpage><lpage>1995</lpage><pub-id pub-id-type="pmid">20576641</pub-id></element-citation></ref><ref id="b0600"><element-citation publication-type="journal" id="h0600"><person-group person-group-type="author"><name><surname>Keiser</surname><given-names>J.</given-names></name><name><surname>Veneziano</surname><given-names>V.</given-names></name><name><surname>Rinaldi</surname><given-names>L.</given-names></name><name><surname>Mezzino</surname><given-names>L.</given-names></name><name><surname>Duthaler</surname><given-names>U.</given-names></name><name><surname>Cringoli</surname><given-names>G.</given-names></name></person-group><article-title>Anthelmintic activity of artesunate against <italic>Fasciola hepatica</italic> in naturally infected sheep</article-title><source>Res. Vet. Sci.</source><volume>88</volume><year>2010</year><fpage>107</fpage><lpage>110</lpage><pub-id pub-id-type="pmid">19501379</pub-id></element-citation></ref><ref id="b1245"><element-citation publication-type="journal" id="h1245"><person-group person-group-type="author"><name><surname>Keiser</surname><given-names>J.</given-names></name><name><surname>Sayed</surname><given-names>H.</given-names></name><name><surname>El-Ghanam</surname><given-names>M.</given-names></name><name><surname>Sabry</surname><given-names>H.</given-names></name><name><surname>Anani</surname><given-names>S.</given-names></name><name><surname>El-Wakeel</surname><given-names>A.</given-names></name><name><surname>Hatz</surname><given-names>C.</given-names></name><name><surname>Utzinger</surname><given-names>J.</given-names></name><name><surname>El-Din</surname><given-names>S.S.</given-names></name><name><surname>El-Maadawy</surname><given-names>W.</given-names></name><name><surname>Botros</surname><given-names>S.</given-names></name></person-group><article-title>Efficacy and safety of artemether in the treatment of chronic fascioliasis in Egypt: exploratory phase-2 trials</article-title><source>PLoS Negl. Trop. Dis.</source><volume>5</volume><year>2011</year><fpage>e1285</fpage><pub-id pub-id-type="pmid">21909440</pub-id></element-citation></ref><ref id="b0610"><element-citation publication-type="journal" id="h0610"><person-group person-group-type="author"><name><surname>Keiser</surname><given-names>J.</given-names></name><name><surname>Ingram</surname><given-names>K.</given-names></name><name><surname>Vargas</surname><given-names>M.</given-names></name><name><surname>Chollet</surname><given-names>J.</given-names></name><name><surname>Wang</surname><given-names>X.</given-names></name><name><surname>Dong</surname><given-names>Y.</given-names></name><name><surname>Vennerstrom</surname><given-names>J.L.</given-names></name></person-group><article-title><italic>In vivo</italic> activity of aryl ozonides against <italic>Schistosoma</italic> species</article-title><source>Antimicrob. Agents Chemother.</source><volume>56</volume><year>2012</year><fpage>1090</fpage><lpage>1092</lpage><pub-id pub-id-type="pmid">22106214</pub-id></element-citation></ref><ref id="b0615"><element-citation publication-type="journal" id="h0615"><person-group person-group-type="author"><name><surname>Keiser</surname><given-names>J.</given-names></name><name><surname>Tritten</surname><given-names>L.</given-names></name><name><surname>Adelfio</surname><given-names>R.</given-names></name><name><surname>Vargas</surname><given-names>M.</given-names></name></person-group><article-title>Effect of combinations of marketed human anthelmintic drugs against <italic>Trichuris muris in vitro</italic> and <italic>in vivo</italic></article-title><source>Parasite Vectors</source><volume>5</volume><year>2012</year><fpage>292</fpage></element-citation></ref><ref id="b0620"><element-citation publication-type="journal" id="h0620"><person-group person-group-type="author"><name><surname>Keiser</surname><given-names>J.</given-names></name><name><surname>Adelfio</surname><given-names>R.</given-names></name><name><surname>Vargas</surname><given-names>M.</given-names></name><name><surname>Odermatt</surname><given-names>P.</given-names></name><name><surname>Tesana</surname><given-names>S.</given-names></name></person-group><article-title>Activity of tribendimidine and praziquantel combination therapy against the liver fluke <italic>Opisthorchis viverrini in vitro</italic> and <italic>in vivo</italic></article-title><source>J. Helminthol.</source><volume>87</volume><year>2013</year><fpage>252</fpage><lpage>256</lpage><pub-id pub-id-type="pmid">22892101</pub-id></element-citation></ref><ref id="b0625"><element-citation publication-type="journal" id="h0625"><person-group person-group-type="author"><name><surname>Keiser</surname><given-names>J.</given-names></name><name><surname>Tritten</surname><given-names>L.</given-names></name><name><surname>Silbereisen</surname><given-names>A.</given-names></name><name><surname>Speich</surname><given-names>B.</given-names></name><name><surname>Adelfio</surname><given-names>R.</given-names></name><name><surname>Vargas</surname><given-names>M.</given-names></name></person-group><article-title>Activity of oxantel pamoate monotherapy and combination chemotherapy against <italic>Trichuris muris</italic> and hookworms: revival of an old drug</article-title><source>PLoS Negl. Trop. Dis.</source><volume>7</volume><year>2013</year><fpage>e2119</fpage><pub-id pub-id-type="pmid">23556013</pub-id></element-citation></ref><ref id="b0630"><element-citation publication-type="journal" id="h0630"><person-group person-group-type="author"><name><surname>Kern</surname><given-names>P.</given-names></name></person-group><article-title>Medical treatment of echinococcosis under the guidance of Good Clinical Practice (GCP/ICH)</article-title><source>Parasitol. Int.</source><volume>55</volume><issue>Suppl.</issue><year>2006</year><fpage>S273</fpage><lpage>S282</lpage><pub-id pub-id-type="pmid">16338164</pub-id></element-citation></ref><ref id="b0635"><element-citation publication-type="journal" id="h0635"><person-group person-group-type="author"><name><surname>Knopp</surname><given-names>S.</given-names></name><name><surname>Steinmann</surname><given-names>P.</given-names></name><name><surname>Hatz</surname><given-names>C.</given-names></name><name><surname>Keiser</surname><given-names>J.</given-names></name><name><surname>Utzinger</surname><given-names>J.</given-names></name></person-group><article-title>Nematode infections: filariases</article-title><source>Infect. Dis. Clin. North Am.</source><volume>26</volume><year>2012</year><fpage>359</fpage><lpage>381</lpage><pub-id pub-id-type="pmid">22632644</pub-id></element-citation></ref><ref id="b0640"><element-citation publication-type="journal" id="h0640"><person-group person-group-type="author"><name><surname>Knopp</surname><given-names>S.</given-names></name><name><surname>Steinmann</surname><given-names>P.</given-names></name><name><surname>Keiser</surname><given-names>J.</given-names></name><name><surname>Utzinger</surname><given-names>J.</given-names></name></person-group><article-title>Nematode infections: soil-transmitted helminths and trichinella</article-title><source>Infect. Dis. Clin. North Am.</source><volume>26</volume><year>2012</year><fpage>341</fpage><lpage>358</lpage><pub-id pub-id-type="pmid">22632643</pub-id></element-citation></ref><ref id="b0645"><element-citation publication-type="journal" id="h0645"><person-group person-group-type="author"><name><surname>Knopp</surname><given-names>S.</given-names></name><name><surname>Becker</surname><given-names>S.L.</given-names></name><name><surname>Ingram</surname><given-names>K.J.</given-names></name><name><surname>Keiser</surname><given-names>J.</given-names></name><name><surname>Utzinger</surname><given-names>J.</given-names></name></person-group><article-title>Diagnosis and treatment of schistosomiasis in children in the era of intensified control</article-title><source>Expert Rev. Anti. Infect. Ther.</source><volume>11</volume><year>2013</year><fpage>1237</fpage><lpage>1258</lpage><pub-id pub-id-type="pmid">24127662</pub-id></element-citation></ref><ref id="b0650"><element-citation publication-type="journal" id="h0650"><person-group person-group-type="author"><name><surname>Koul</surname><given-names>P.A.</given-names></name><name><surname>Wahid</surname><given-names>A.</given-names></name><name><surname>Bhat</surname><given-names>M.H.</given-names></name><name><surname>Wani</surname><given-names>J.I.</given-names></name><name><surname>Sofi</surname><given-names>B.A.</given-names></name></person-group><article-title>Mepacrine therapy in niclosamide resistant taeniasis</article-title><source>J. Assoc. Physicians India</source><volume>48</volume><year>2000</year><fpage>402</fpage><lpage>403</lpage><pub-id pub-id-type="pmid">11273175</pub-id></element-citation></ref><ref id="b0655"><element-citation publication-type="journal" id="h0655"><person-group person-group-type="author"><name><surname>Kulke</surname><given-names>D.</given-names></name><name><surname>Krucken</surname><given-names>J.</given-names></name><name><surname>Welz</surname><given-names>C.</given-names></name><name><surname>von Samson-Himmelstjerna</surname><given-names>G.</given-names></name><name><surname>Harder</surname><given-names>A.</given-names></name></person-group><article-title><italic>In vivo</italic> efficacy of the anthelmintic tribendimidine against the cestode <italic>Hymenolepis microstoma</italic> in a controlled laboratory trial</article-title><source>Acta Trop.</source><volume>123</volume><year>2012</year><fpage>78</fpage><lpage>84</lpage><pub-id pub-id-type="pmid">22487754</pub-id></element-citation></ref><ref id="b0660"><element-citation publication-type="journal" id="h0660"><person-group person-group-type="author"><name><surname>Kulke</surname><given-names>D.</given-names></name><name><surname>Krücken</surname><given-names>J.</given-names></name><name><surname>Harder</surname><given-names>A.</given-names></name><name><surname>Samson-Himmelstjerna</surname><given-names>G.</given-names></name></person-group><article-title>Efficacy of cyclooctadepsipeptides and aminophenylamides against larval, immature and mature adult stages of a parasitologically characterized trichurosis model in mice</article-title><source>PLoS Negl. Trop. Dis.</source><volume>8</volume><issue>2</issue><year>2014</year><fpage>e2698</fpage><pub-id pub-id-type="pmid">24587460</pub-id></element-citation></ref><ref id="b0665"><element-citation publication-type="journal" id="h0665"><person-group person-group-type="author"><name><surname>Kuster</surname><given-names>T.</given-names></name><name><surname>Stadelmann</surname><given-names>B.</given-names></name><name><surname>Hermann</surname><given-names>C.</given-names></name><name><surname>Scholl</surname><given-names>S.</given-names></name><name><surname>Keiser</surname><given-names>J.</given-names></name><name><surname>Hemphill</surname><given-names>A.</given-names></name></person-group><article-title><italic>In vitro</italic> and <italic>in vivo</italic> efficacies of mefloquine-based treatment against alveolar echinococcosis</article-title><source>Antimicrob. Agents Chemother.</source><volume>55</volume><year>2011</year><fpage>713</fpage><lpage>721</lpage><pub-id pub-id-type="pmid">21135182</pub-id></element-citation></ref><ref id="b0670"><element-citation publication-type="journal" id="h0670"><person-group person-group-type="author"><name><surname>Lanusse</surname><given-names>C.E.</given-names></name><name><surname>Virkel</surname><given-names>G.L.</given-names></name><name><surname>Sanchez</surname><given-names>S.F.</given-names></name><name><surname>Alvarez</surname><given-names>L.I.</given-names></name><name><surname>Lifschitz</surname><given-names>A.L.</given-names></name><name><surname>Imperiale</surname><given-names>F.</given-names></name><name><surname>Monfrinotti</surname><given-names>A.</given-names></name></person-group><article-title>Ricobendazole kinetics and availability following subcutaneous administration of a novel injectable formulation to calves</article-title><source>Res. Vet. Sci.</source><volume>65</volume><year>1998</year><fpage>5</fpage><lpage>10</lpage><pub-id pub-id-type="pmid">9769065</pub-id></element-citation></ref><ref id="b0675"><element-citation publication-type="journal" id="h0675"><person-group person-group-type="author"><name><surname>Lateef</surname><given-names>M.</given-names></name><name><surname>Zargar</surname><given-names>S.A.</given-names></name><name><surname>Khan</surname><given-names>A.R.</given-names></name><name><surname>Nazir</surname><given-names>M.</given-names></name><name><surname>Shoukat</surname><given-names>A.</given-names></name></person-group><article-title>Successful treatment of niclosamide and praziquantel-resistant beef tapeworm infection with nitazoxanide</article-title><source>Int. J. Infect. Dis. IJID</source><volume>12</volume><year>2008</year><fpage>80</fpage><lpage>82</lpage></element-citation></ref><ref id="b0680"><element-citation publication-type="journal" id="h0680"><person-group person-group-type="author"><name><surname>Lee</surname><given-names>E.L.</given-names></name><name><surname>Iyngkaran</surname><given-names>N.</given-names></name><name><surname>Grieve</surname><given-names>A.W.</given-names></name><name><surname>Robinson</surname><given-names>M.J.</given-names></name><name><surname>Dissanaike</surname><given-names>A.S.</given-names></name></person-group><article-title>Therapeutic evaluation of oxantel pamoate (1,4,5,6-tetrahydro-1-methyl-2-[trans-3-hydroxystyryl] pyrimidine pamoate) in severe <italic>Trichuris trichiura</italic> infection</article-title><source>Am. J. Trop. Med. Hyg.</source><volume>25</volume><year>1976</year><fpage>563</fpage><lpage>567</lpage><pub-id pub-id-type="pmid">961973</pub-id></element-citation></ref><ref id="b0685"><element-citation publication-type="journal" id="h0685"><person-group person-group-type="author"><name><surname>Lee</surname><given-names>S.H.</given-names></name><name><surname>Lim</surname><given-names>J.K.</given-names></name></person-group><article-title>Comparative study of effect of oxantel-pyrantel suspension and mebendazole in mixed infections with <italic>Ascaris</italic> and <italic>Trichuris</italic></article-title><source>Drugs</source><volume>15</volume><year>1978</year><fpage>94</fpage><lpage>98</lpage><pub-id pub-id-type="pmid">657997</pub-id></element-citation></ref><ref id="b0690"><element-citation publication-type="journal" id="h0690"><person-group person-group-type="author"><name><surname>Li</surname><given-names>H.J.</given-names></name><name><surname>Wang</surname><given-names>W.</given-names></name><name><surname>Qu</surname><given-names>G.L.</given-names></name><name><surname>Tao</surname><given-names>Y.H.</given-names></name><name><surname>Xing</surname><given-names>Y.T.</given-names></name><name><surname>Li</surname><given-names>Y.Z.</given-names></name><name><surname>Wei</surname><given-names>J.Y.</given-names></name><name><surname>Dai</surname><given-names>J.R.</given-names></name><name><surname>Liang</surname><given-names>Y.S.</given-names></name></person-group><article-title><italic>In vivo</italic> activity of dihydroartemisinin against <italic>Schistosoma japonicum</italic></article-title><source>Ann. Trop. Med. Parasitol.</source><volume>105</volume><year>2011</year><fpage>181</fpage><lpage>185</lpage><pub-id pub-id-type="pmid">21396254</pub-id></element-citation></ref><ref id="b0695"><element-citation publication-type="journal" id="h0695"><person-group person-group-type="author"><name><surname>Li</surname><given-names>H.J.</given-names></name><name><surname>Wang</surname><given-names>W.</given-names></name><name><surname>Qu</surname><given-names>G.L.</given-names></name><name><surname>Li</surname><given-names>Y.Z.</given-names></name><name><surname>Tao</surname><given-names>Y.H.</given-names></name><name><surname>Xing</surname><given-names>Y.T.</given-names></name><name><surname>Wang</surname><given-names>X.T.</given-names></name><name><surname>Dai</surname><given-names>Y.</given-names></name><name><surname>Wei</surname><given-names>J.Y.</given-names></name><name><surname>Dai</surname><given-names>J.R.</given-names></name><name><surname>Coles</surname><given-names>G.C.</given-names></name><name><surname>Liang</surname><given-names>Y.S.</given-names></name></person-group><article-title>Effect of the <italic>in vivo</italic> activity of dihydroartemisinin against <italic>Schistosoma mansoni</italic> infection in mice</article-title><source>Parasitol. Res.</source><volume>110</volume><year>2012</year><fpage>1727</fpage><lpage>1732</lpage><pub-id pub-id-type="pmid">22006193</pub-id></element-citation></ref><ref id="b0700"><element-citation publication-type="journal" id="h0700"><person-group person-group-type="author"><name><surname>Li</surname><given-names>H.J.</given-names></name><name><surname>Xu</surname><given-names>F.L.</given-names></name><name><surname>Wang</surname><given-names>Y.H.</given-names></name><name><surname>Yi</surname><given-names>Z.J.</given-names></name><name><surname>Wang</surname><given-names>W.</given-names></name></person-group><article-title>Dihydroartemisinin: a new story of an old drug against <italic>Schistosoma mansoni</italic> infection</article-title><source>Parasitol. Res.</source><volume>113</volume><year>2014</year><fpage>239</fpage><lpage>241</lpage><pub-id pub-id-type="pmid">24146209</pub-id></element-citation></ref><ref id="b0705"><element-citation publication-type="journal" id="h0705"><person-group person-group-type="author"><name><surname>Link</surname><given-names>H.</given-names></name><name><surname>Stohler</surname><given-names>H.R.</given-names></name></person-group><article-title>3-Arylhydantoine, eine Substanzklasse mit schistosomizider Wirkung</article-title><source>Eur. J. Med. Chem.</source><volume>19</volume><year>1984</year><fpage>261</fpage><lpage>265</lpage></element-citation></ref><ref id="b0710"><element-citation publication-type="journal" id="h0710"><person-group person-group-type="author"><name><surname>Liu</surname><given-names>R.</given-names></name><name><surname>Dong</surname><given-names>H.F.</given-names></name><name><surname>Guo</surname><given-names>Y.</given-names></name><name><surname>Zhao</surname><given-names>Q.P.</given-names></name><name><surname>Jiang</surname><given-names>M.S.</given-names></name></person-group><article-title>Efficacy of praziquantel and artemisinin derivatives for the treatment and prevention of human schistosomiasis: a systematic review and meta-analysis</article-title><source>Parasite Vectors</source><volume>4</volume><year>2011</year><fpage>201</fpage></element-citation></ref><ref id="b0715"><element-citation publication-type="journal" id="h0715"><person-group person-group-type="author"><name><surname>Lumaret</surname><given-names>J.P.</given-names></name><name><surname>Errouissi</surname><given-names>F.</given-names></name><name><surname>Floate</surname><given-names>K.</given-names></name><name><surname>Rombke</surname><given-names>J.</given-names></name><name><surname>Wardhaugh</surname><given-names>K.</given-names></name></person-group><article-title>A review on the toxicity and non-target effects of macrocyclic lactones in terrestrial and aquatic environments</article-title><source>Curr. Pharm. Biotechnol.</source><volume>13</volume><year>2012</year><fpage>1004</fpage><lpage>1060</lpage><pub-id pub-id-type="pmid">22039795</pub-id></element-citation></ref><ref id="b0720"><element-citation publication-type="journal" id="h0720"><person-group person-group-type="author"><name><surname>Lyons</surname><given-names>E.T.</given-names></name><name><surname>Tolliver</surname><given-names>S.C.</given-names></name><name><surname>Collins</surname><given-names>S.S.</given-names></name></person-group><article-title>Field studies on endoparasites of thoroughbred foals on seven farms in central Kentucky in 2004</article-title><source>Parasitol. Res.</source><volume>98</volume><year>2006</year><fpage>496</fpage><lpage>500</lpage><pub-id pub-id-type="pmid">16385405</pub-id></element-citation></ref><ref id="b0725"><element-citation publication-type="journal" id="h0725"><person-group person-group-type="author"><name><surname>Mackenzie</surname><given-names>C.D.</given-names></name><name><surname>Geary</surname><given-names>T.G.</given-names></name></person-group><article-title>Flubendazole: a candidate macrofilaricide for lymphatic filariasis and onchocerciasis field programs</article-title><source>Expert Rev. Anti Infect. Ther.</source><volume>9</volume><year>2011</year><fpage>497</fpage><lpage>501</lpage><pub-id pub-id-type="pmid">21609260</pub-id></element-citation></ref><ref id="b0730"><element-citation publication-type="journal" id="h0730"><person-group person-group-type="author"><name><surname>Mand</surname><given-names>S.</given-names></name><name><surname>Pfarr</surname><given-names>K.</given-names></name><name><surname>Sahoo</surname><given-names>P.K.</given-names></name><name><surname>Satapathy</surname><given-names>A.K.</given-names></name><name><surname>Specht</surname><given-names>S.</given-names></name><name><surname>Klarmann</surname><given-names>U.</given-names></name><name><surname>Debrah</surname><given-names>A.Y.</given-names></name><name><surname>Ravindran</surname><given-names>B.</given-names></name><name><surname>Hoerauf</surname><given-names>A.</given-names></name></person-group><article-title>Macrofilaricidal activity and amelioration of lymphatic pathology in bancroftian filariasis after 3 weeks of doxycycline followed by single-dose diethylcarbamazine</article-title><source>Am. J. Trop. Med. Hyg.</source><volume>81</volume><year>2009</year><fpage>702</fpage><lpage>711</lpage><pub-id pub-id-type="pmid">19815891</pub-id></element-citation></ref><ref id="b0735"><element-citation publication-type="journal" id="h0735"><person-group person-group-type="author"><name><surname>Mand</surname><given-names>S.</given-names></name><name><surname>Debrah</surname><given-names>A.Y.</given-names></name><name><surname>Klarmann</surname><given-names>U.</given-names></name><name><surname>Batsa</surname><given-names>L.</given-names></name><name><surname>Marfo-Debrekyei</surname><given-names>Y.</given-names></name><name><surname>Kwarteng</surname><given-names>A.</given-names></name><name><surname>Specht</surname><given-names>S.</given-names></name><name><surname>Belda-Domene</surname><given-names>A.</given-names></name><name><surname>Fimmers</surname><given-names>R.</given-names></name><name><surname>Taylor</surname><given-names>M.</given-names></name><name><surname>Adjei</surname><given-names>O.</given-names></name><name><surname>Hoerauf</surname><given-names>A.</given-names></name></person-group><article-title>Doxycycline improves filarial lymphedema independent of active filarial infection: a randomized controlled trial</article-title><source>Clin. Infect. Dis.</source><volume>55</volume><year>2012</year><fpage>621</fpage><lpage>630</lpage><pub-id pub-id-type="pmid">22610930</pub-id></element-citation></ref><ref id="b1250"><element-citation publication-type="journal" id="h0750"><person-group person-group-type="author"><name><surname>Mansour-Ghanaei</surname><given-names>F.</given-names></name><name><surname>Shafaghi</surname><given-names>A.</given-names></name><name><surname>Fallah</surname><given-names>M.</given-names></name></person-group><article-title>The effect of metronidazole in treating human fascioliasis</article-title><source>Med. Sci. Monit.</source><volume>9</volume><year>2003</year><fpage>Pi127</fpage><lpage>Pi130</lpage><pub-id pub-id-type="pmid">14523339</pub-id></element-citation></ref><ref id="b1300"><element-citation publication-type="journal" id="h1290"><person-group person-group-type="author"><name><surname>Masud</surname><given-names>H.</given-names></name><name><surname>Qureshi</surname><given-names>T.Q.</given-names></name><name><surname>Dukley</surname><given-names>M.</given-names></name></person-group><article-title>Effects of Ivermectin with and without doxycycline on clinical symptoms of onchocerciasis</article-title><source>J. Coll. Physicians Surg. Pak.</source><volume>19</volume><year>2009</year><fpage>34</fpage><lpage>38</lpage><pub-id pub-id-type="pmid">19149978</pub-id></element-citation></ref><ref id="b1305"><element-citation publication-type="journal" id="h1295"><person-group person-group-type="author"><name><surname>McMahon</surname><given-names>J.E.</given-names></name></person-group><article-title>Chemotherapy with diethylcarbamazine and levamisole in Bancroftian filariasis</article-title><source>Tropenmedizin Parasitol.</source><volume>32</volume><year>1981</year><fpage>250</fpage><lpage>252</lpage></element-citation></ref><ref id="b0755"><element-citation publication-type="journal" id="h0755"><person-group person-group-type="author"><name><surname>Meister</surname><given-names>I.</given-names></name><name><surname>Duthaler</surname><given-names>U.</given-names></name><name><surname>Huwyler</surname><given-names>J.</given-names></name><name><surname>Rinaldi</surname><given-names>L.</given-names></name><name><surname>Bosco</surname><given-names>A.</given-names></name><name><surname>Cringoli</surname><given-names>G.</given-names></name><name><surname>Keiser</surname><given-names>J.</given-names></name></person-group><article-title>Efficacy and pharmacokinetics of OZ78 and MT04 against a natural infection with <italic>Fasciola hepatica</italic> in sheep</article-title><source>Vet. Parasitol.</source><volume>198</volume><year>2013</year><fpage>102</fpage><lpage>110</lpage><pub-id pub-id-type="pmid">24011678</pub-id></element-citation></ref><ref id="b0760"><element-citation publication-type="journal" id="h0760"><person-group person-group-type="author"><name><surname>Mossallam</surname><given-names>S.F.</given-names></name><name><surname>Ali</surname><given-names>S.M.</given-names></name><name><surname>El Zawawy</surname><given-names>L.A.</given-names></name><name><surname>Said</surname><given-names>D.E.</given-names></name></person-group><article-title>The efficacy of antihelminthic compound; Clorsulon against experimental <italic>Schistosoma mansoni</italic> infection</article-title><source>J. Egypt. Soc. Parasitol.</source><volume>37</volume><year>2007</year><fpage>171</fpage><lpage>188</lpage><pub-id pub-id-type="pmid">17580576</pub-id></element-citation></ref><ref id="b0765"><element-citation publication-type="journal" id="h0765"><person-group person-group-type="author"><name><surname>Murray</surname><given-names>C.J.</given-names></name><name><surname>Vos</surname><given-names>T.</given-names></name><name><surname>Lozano</surname><given-names>R.</given-names></name><name><surname>Naghavi</surname><given-names>M.</given-names></name><name><surname>Flaxman</surname><given-names>A.D.</given-names></name><name><surname>Michaud</surname><given-names>C.</given-names></name><name><surname>Ezzati</surname><given-names>M.</given-names></name><name><surname>Shibuya</surname><given-names>K.</given-names></name><name><surname>Salomon</surname><given-names>J.A.</given-names></name><name><surname>Abdalla</surname><given-names>S.</given-names></name><name><surname>Aboyans</surname><given-names>V.</given-names></name><name><surname>Abraham</surname><given-names>J.</given-names></name><name><surname>Ackerman</surname><given-names>I.</given-names></name><name><surname>Aggarwal</surname><given-names>R.</given-names></name><name><surname>Ahn</surname><given-names>S.Y.</given-names></name><name><surname>Ali</surname><given-names>M.K.</given-names></name><name><surname>Alvarado</surname><given-names>M.</given-names></name><name><surname>Anderson</surname><given-names>H.R.</given-names></name><name><surname>Anderson</surname><given-names>L.M.</given-names></name><name><surname>Andrews</surname><given-names>K.G.</given-names></name><name><surname>Atkinson</surname><given-names>C.</given-names></name><name><surname>Baddour</surname><given-names>L.M.</given-names></name><name><surname>Bahalim</surname><given-names>A.N.</given-names></name><name><surname>Barker-Collo</surname><given-names>S.</given-names></name><name><surname>Barrero</surname><given-names>L.H.</given-names></name><name><surname>Bartels</surname><given-names>D.H.</given-names></name><name><surname>Basanez</surname><given-names>M.G.</given-names></name><name><surname>Baxter</surname><given-names>A.</given-names></name><name><surname>Bell</surname><given-names>M.L.</given-names></name><name><surname>Benjamin</surname><given-names>E.J.</given-names></name><name><surname>Bennett</surname><given-names>D.</given-names></name><name><surname>Bernabe</surname><given-names>E.</given-names></name><name><surname>Bhalla</surname><given-names>K.</given-names></name><name><surname>Bhandari</surname><given-names>B.</given-names></name><name><surname>Bikbov</surname><given-names>B.</given-names></name><name><surname>Bin Abdulhak</surname><given-names>A.</given-names></name><name><surname>Birbeck</surname><given-names>G.</given-names></name><name><surname>Black</surname><given-names>J.A.</given-names></name><name><surname>Blencowe</surname><given-names>H.</given-names></name><name><surname>Blore</surname><given-names>J.D.</given-names></name><name><surname>Blyth</surname><given-names>F.</given-names></name><name><surname>Bolliger</surname><given-names>I.</given-names></name><name><surname>Bonaventure</surname><given-names>A.</given-names></name><name><surname>Boufous</surname><given-names>S.</given-names></name><name><surname>Bourne</surname><given-names>R.</given-names></name><name><surname>Boussinesq</surname><given-names>M.</given-names></name><name><surname>Braithwaite</surname><given-names>T.</given-names></name><name><surname>Brayne</surname><given-names>C.</given-names></name><name><surname>Bridgett</surname><given-names>L.</given-names></name><name><surname>Brooker</surname><given-names>S.</given-names></name><name><surname>Brooks</surname><given-names>P.</given-names></name><name><surname>Brugha</surname><given-names>T.S.</given-names></name><name><surname>Bryan-Hancock</surname><given-names>C.</given-names></name><name><surname>Bucello</surname><given-names>C.</given-names></name><name><surname>Buchbinder</surname><given-names>R.</given-names></name><name><surname>Buckle</surname><given-names>G.</given-names></name><name><surname>Budke</surname><given-names>C.M.</given-names></name><name><surname>Burch</surname><given-names>M.</given-names></name><name><surname>Burney</surname><given-names>P.</given-names></name><name><surname>Burstein</surname><given-names>R.</given-names></name><name><surname>Calabria</surname><given-names>B.</given-names></name><name><surname>Campbell</surname><given-names>B.</given-names></name><name><surname>Canter</surname><given-names>C.E.</given-names></name><name><surname>Carabin</surname><given-names>H.</given-names></name><name><surname>Carapetis</surname><given-names>J.</given-names></name><name><surname>Carmona</surname><given-names>L.</given-names></name><name><surname>Cella</surname><given-names>C.</given-names></name><name><surname>Charlson</surname><given-names>F.</given-names></name><name><surname>Chen</surname><given-names>H.</given-names></name><name><surname>Cheng</surname><given-names>A.T.</given-names></name><name><surname>Chou</surname><given-names>D.</given-names></name><name><surname>Chugh</surname><given-names>S.S.</given-names></name><name><surname>Coffeng</surname><given-names>L.E.</given-names></name><name><surname>Colan</surname><given-names>S.D.</given-names></name><name><surname>Colquhoun</surname><given-names>S.</given-names></name><name><surname>Colson</surname><given-names>K.E.</given-names></name><name><surname>Condon</surname><given-names>J.</given-names></name><name><surname>Connor</surname><given-names>M.D.</given-names></name><name><surname>Cooper</surname><given-names>L.T.</given-names></name><name><surname>Corriere</surname><given-names>M.</given-names></name><name><surname>Cortinovis</surname><given-names>M.</given-names></name><name><surname>de Vaccaro</surname><given-names>K.C.</given-names></name><name><surname>Couser</surname><given-names>W.</given-names></name><name><surname>Cowie</surname><given-names>B.C.</given-names></name><name><surname>Criqui</surname><given-names>M.H.</given-names></name><name><surname>Cross</surname><given-names>M.</given-names></name><name><surname>Dabhadkar</surname><given-names>K.C.</given-names></name><name><surname>Dahiya</surname><given-names>M.</given-names></name><name><surname>Dahodwala</surname><given-names>N.</given-names></name><name><surname>Damsere-Derry</surname><given-names>J.</given-names></name><name><surname>Danaei</surname><given-names>G.</given-names></name><name><surname>Davis</surname><given-names>A.</given-names></name><name><surname>De Leo</surname><given-names>D.</given-names></name><name><surname>Degenhardt</surname><given-names>L.</given-names></name><name><surname>Dellavalle</surname><given-names>R.</given-names></name><name><surname>Delossantos</surname><given-names>A.</given-names></name><name><surname>Denenberg</surname><given-names>J.</given-names></name><name><surname>Derrett</surname><given-names>S.</given-names></name><name><surname>Des Jarlais</surname><given-names>D.C.</given-names></name><name><surname>Dharmaratne</surname><given-names>S.D.</given-names></name><name><surname>Dherani</surname><given-names>M.</given-names></name><name><surname>Diaz-Torne</surname><given-names>C.</given-names></name><name><surname>Dolk</surname><given-names>H.</given-names></name><name><surname>Dorsey</surname><given-names>E.R.</given-names></name><name><surname>Driscoll</surname><given-names>T.</given-names></name><name><surname>Duber</surname><given-names>H.</given-names></name><name><surname>Ebel</surname><given-names>B.</given-names></name><name><surname>Edmond</surname><given-names>K.</given-names></name><name><surname>Elbaz</surname><given-names>A.</given-names></name><name><surname>Ali</surname><given-names>S.E.</given-names></name><name><surname>Erskine</surname><given-names>H.</given-names></name><name><surname>Erwin</surname><given-names>P.J.</given-names></name><name><surname>Espindola</surname><given-names>P.</given-names></name><name><surname>Ewoigbokhan</surname><given-names>S.E.</given-names></name><name><surname>Farzadfar</surname><given-names>F.</given-names></name><name><surname>Feigin</surname><given-names>V.</given-names></name><name><surname>Felson</surname><given-names>D.T.</given-names></name><name><surname>Ferrari</surname><given-names>A.</given-names></name><name><surname>Ferri</surname><given-names>C.P.</given-names></name><name><surname>Fevre</surname><given-names>E.M.</given-names></name><name><surname>Finucane</surname><given-names>M.M.</given-names></name><name><surname>Flaxman</surname><given-names>S.</given-names></name><name><surname>Flood</surname><given-names>L.</given-names></name><name><surname>Foreman</surname><given-names>K.</given-names></name><name><surname>Forouzanfar</surname><given-names>M.H.</given-names></name><name><surname>Fowkes</surname><given-names>F.G.</given-names></name><name><surname>Fransen</surname><given-names>M.</given-names></name><name><surname>Freeman</surname><given-names>M.K.</given-names></name><name><surname>Gabbe</surname><given-names>B.J.</given-names></name><name><surname>Gabriel</surname><given-names>S.E.</given-names></name><name><surname>Gakidou</surname><given-names>E.</given-names></name><name><surname>Ganatra</surname><given-names>H.A.</given-names></name><name><surname>Garcia</surname><given-names>B.</given-names></name><name><surname>Gaspari</surname><given-names>F.</given-names></name><name><surname>Gillum</surname><given-names>R.F.</given-names></name><name><surname>Gmel</surname><given-names>G.</given-names></name><name><surname>Gonzalez-Medina</surname><given-names>D.</given-names></name><name><surname>Gosselin</surname><given-names>R.</given-names></name><name><surname>Grainger</surname><given-names>R.</given-names></name><name><surname>Grant</surname><given-names>B.</given-names></name><name><surname>Groeger</surname><given-names>J.</given-names></name><name><surname>Guillemin</surname><given-names>F.</given-names></name><name><surname>Gunnell</surname><given-names>D.</given-names></name><name><surname>Gupta</surname><given-names>R.</given-names></name><name><surname>Haagsma</surname><given-names>J.</given-names></name><name><surname>Hagan</surname><given-names>H.</given-names></name><name><surname>Halasa</surname><given-names>Y.A.</given-names></name><name><surname>Hall</surname><given-names>W.</given-names></name><name><surname>Haring</surname><given-names>D.</given-names></name><name><surname>Haro</surname><given-names>J.M.</given-names></name><name><surname>Harrison</surname><given-names>J.E.</given-names></name><name><surname>Havmoeller</surname><given-names>R.</given-names></name><name><surname>Hay</surname><given-names>R.J.</given-names></name><name><surname>Higashi</surname><given-names>H.</given-names></name><name><surname>Hill</surname><given-names>C.</given-names></name><name><surname>Hoen</surname><given-names>B.</given-names></name><name><surname>Hoffman</surname><given-names>H.</given-names></name><name><surname>Hotez</surname><given-names>P.J.</given-names></name><name><surname>Hoy</surname><given-names>D.</given-names></name><name><surname>Huang</surname><given-names>J.J.</given-names></name><name><surname>Ibeanusi</surname><given-names>S.E.</given-names></name><name><surname>Jacobsen</surname><given-names>K.H.</given-names></name><name><surname>James</surname><given-names>S.L.</given-names></name><name><surname>Jarvis</surname><given-names>D.</given-names></name><name><surname>Jasrasaria</surname><given-names>R.</given-names></name><name><surname>Jayaraman</surname><given-names>S.</given-names></name><name><surname>Johns</surname><given-names>N.</given-names></name><name><surname>Jonas</surname><given-names>J.B.</given-names></name><name><surname>Karthikeyan</surname><given-names>G.</given-names></name><name><surname>Kassebaum</surname><given-names>N.</given-names></name><name><surname>Kawakami</surname><given-names>N.</given-names></name><name><surname>Keren</surname><given-names>A.</given-names></name><name><surname>Khoo</surname><given-names>J.P.</given-names></name><name><surname>King</surname><given-names>C.H.</given-names></name><name><surname>Knowlton</surname><given-names>L.M.</given-names></name><name><surname>Kobusingye</surname><given-names>O.</given-names></name><name><surname>Koranteng</surname><given-names>A.</given-names></name><name><surname>Krishnamurthi</surname><given-names>R.</given-names></name><name><surname>Laden</surname><given-names>F.</given-names></name><name><surname>Lalloo</surname><given-names>R.</given-names></name><name><surname>Laslett</surname><given-names>L.L.</given-names></name><name><surname>Lathlean</surname><given-names>T.</given-names></name><name><surname>Leasher</surname><given-names>J.L.</given-names></name><name><surname>Lee</surname><given-names>Y.Y.</given-names></name><name><surname>Leigh</surname><given-names>J.</given-names></name><name><surname>Levinson</surname><given-names>D.</given-names></name><name><surname>Lim</surname><given-names>S.S.</given-names></name><name><surname>Limb</surname><given-names>E.</given-names></name><name><surname>Lin</surname><given-names>J.K.</given-names></name><name><surname>Lipnick</surname><given-names>M.</given-names></name><name><surname>Lipshultz</surname><given-names>S.E.</given-names></name><name><surname>Liu</surname><given-names>W.</given-names></name><name><surname>Loane</surname><given-names>M.</given-names></name><name><surname>Ohno</surname><given-names>S.L.</given-names></name><name><surname>Lyons</surname><given-names>R.</given-names></name><name><surname>Mabweijano</surname><given-names>J.</given-names></name><name><surname>MacIntyre</surname><given-names>M.F.</given-names></name><name><surname>Malekzadeh</surname><given-names>R.</given-names></name><name><surname>Mallinger</surname><given-names>L.</given-names></name><name><surname>Manivannan</surname><given-names>S.</given-names></name><name><surname>Marcenes</surname><given-names>W.</given-names></name><name><surname>March</surname><given-names>L.</given-names></name><name><surname>Margolis</surname><given-names>D.J.</given-names></name><name><surname>Marks</surname><given-names>G.B.</given-names></name><name><surname>Marks</surname><given-names>R.</given-names></name><name><surname>Matsumori</surname><given-names>A.</given-names></name><name><surname>Matzopoulos</surname><given-names>R.</given-names></name><name><surname>Mayosi</surname><given-names>B.M.</given-names></name><name><surname>McAnulty</surname><given-names>J.H.</given-names></name><name><surname>McDermott</surname><given-names>M.M.</given-names></name><name><surname>McGill</surname><given-names>N.</given-names></name><name><surname>McGrath</surname><given-names>J.</given-names></name><name><surname>Medina-Mora</surname><given-names>M.E.</given-names></name><name><surname>Meltzer</surname><given-names>M.</given-names></name><name><surname>Mensah</surname><given-names>G.A.</given-names></name><name><surname>Merriman</surname><given-names>T.R.</given-names></name><name><surname>Meyer</surname><given-names>A.C.</given-names></name><name><surname>Miglioli</surname><given-names>V.</given-names></name><name><surname>Miller</surname><given-names>M.</given-names></name><name><surname>Miller</surname><given-names>T.R.</given-names></name><name><surname>Mitchell</surname><given-names>P.B.</given-names></name><name><surname>Mock</surname><given-names>C.</given-names></name><name><surname>Mocumbi</surname><given-names>A.O.</given-names></name><name><surname>Moffitt</surname><given-names>T.E.</given-names></name><name><surname>Mokdad</surname><given-names>A.A.</given-names></name><name><surname>Monasta</surname><given-names>L.</given-names></name><name><surname>Montico</surname><given-names>M.</given-names></name><name><surname>Moradi-Lakeh</surname><given-names>M.</given-names></name><name><surname>Moran</surname><given-names>A.</given-names></name><name><surname>Morawska</surname><given-names>L.</given-names></name><name><surname>Mori</surname><given-names>R.</given-names></name><name><surname>Murdoch</surname><given-names>M.E.</given-names></name><name><surname>Mwaniki</surname><given-names>M.K.</given-names></name><name><surname>Naidoo</surname><given-names>K.</given-names></name><name><surname>Nair</surname><given-names>M.N.</given-names></name><name><surname>Naldi</surname><given-names>L.</given-names></name><name><surname>Narayan</surname><given-names>K.M.</given-names></name><name><surname>Nelson</surname><given-names>P.K.</given-names></name><name><surname>Nelson</surname><given-names>R.G.</given-names></name><name><surname>Nevitt</surname><given-names>M.C.</given-names></name><name><surname>Newton</surname><given-names>C.R.</given-names></name><name><surname>Nolte</surname><given-names>S.</given-names></name><name><surname>Norman</surname><given-names>P.</given-names></name><name><surname>Norman</surname><given-names>R.</given-names></name><name><surname>O’Donnell</surname><given-names>M.</given-names></name><name><surname>O’Hanlon</surname><given-names>S.</given-names></name><name><surname>Olives</surname><given-names>C.</given-names></name><name><surname>Omer</surname><given-names>S.B.</given-names></name><name><surname>Ortblad</surname><given-names>K.</given-names></name><name><surname>Osborne</surname><given-names>R.</given-names></name><name><surname>Ozgediz</surname><given-names>D.</given-names></name><name><surname>Page</surname><given-names>A.</given-names></name><name><surname>Pahari</surname><given-names>B.</given-names></name><name><surname>Pandian</surname><given-names>J.D.</given-names></name><name><surname>Rivero</surname><given-names>A.P.</given-names></name><name><surname>Patten</surname><given-names>S.B.</given-names></name><name><surname>Pearce</surname><given-names>N.</given-names></name><name><surname>Padilla</surname><given-names>R.P.</given-names></name><name><surname>Perez-Ruiz</surname><given-names>F.</given-names></name><name><surname>Perico</surname><given-names>N.</given-names></name><name><surname>Pesudovs</surname><given-names>K.</given-names></name><name><surname>Phillips</surname><given-names>D.</given-names></name><name><surname>Phillips</surname><given-names>M.R.</given-names></name><name><surname>Pierce</surname><given-names>K.</given-names></name><name><surname>Pion</surname><given-names>S.</given-names></name><name><surname>Polanczyk</surname><given-names>G.V.</given-names></name><name><surname>Polinder</surname><given-names>S.</given-names></name><name><surname>Pope</surname><given-names>C.A.</given-names><suffix>3rd</suffix></name><name><surname>Popova</surname><given-names>S.</given-names></name><name><surname>Porrini</surname><given-names>E.</given-names></name><name><surname>Pourmalek</surname><given-names>F.</given-names></name><name><surname>Prince</surname><given-names>M.</given-names></name><name><surname>Pullan</surname><given-names>R.L.</given-names></name><name><surname>Ramaiah</surname><given-names>K.D.</given-names></name><name><surname>Ranganathan</surname><given-names>D.</given-names></name><name><surname>Razavi</surname><given-names>H.</given-names></name><name><surname>Regan</surname><given-names>M.</given-names></name><name><surname>Rehm</surname><given-names>J.T.</given-names></name><name><surname>Rein</surname><given-names>D.B.</given-names></name><name><surname>Remuzzi</surname><given-names>G.</given-names></name><name><surname>Richardson</surname><given-names>K.</given-names></name><name><surname>Rivara</surname><given-names>F.P.</given-names></name><name><surname>Roberts</surname><given-names>T.</given-names></name><name><surname>Robinson</surname><given-names>C.</given-names></name><name><surname>De Leon</surname><given-names>F.R.</given-names></name><name><surname>Ronfani</surname><given-names>L.</given-names></name><name><surname>Room</surname><given-names>R.</given-names></name><name><surname>Rosenfeld</surname><given-names>L.C.</given-names></name><name><surname>Rushton</surname><given-names>L.</given-names></name><name><surname>Sacco</surname><given-names>R.L.</given-names></name><name><surname>Saha</surname><given-names>S.</given-names></name><name><surname>Sampson</surname><given-names>U.</given-names></name><name><surname>Sanchez-Riera</surname><given-names>L.</given-names></name><name><surname>Sanman</surname><given-names>E.</given-names></name><name><surname>Schwebel</surname><given-names>D.C.</given-names></name><name><surname>Scott</surname><given-names>J.G.</given-names></name><name><surname>Segui-Gomez</surname><given-names>M.</given-names></name><name><surname>Shahraz</surname><given-names>S.</given-names></name><name><surname>Shepard</surname><given-names>D.S.</given-names></name><name><surname>Shin</surname><given-names>H.</given-names></name><name><surname>Shivakoti</surname><given-names>R.</given-names></name><name><surname>Singh</surname><given-names>D.</given-names></name><name><surname>Singh</surname><given-names>G.M.</given-names></name><name><surname>Singh</surname><given-names>J.A.</given-names></name><name><surname>Singleton</surname><given-names>J.</given-names></name><name><surname>Sleet</surname><given-names>D.A.</given-names></name><name><surname>Sliwa</surname><given-names>K.</given-names></name><name><surname>Smith</surname><given-names>E.</given-names></name><name><surname>Smith</surname><given-names>J.L.</given-names></name><name><surname>Stapelberg</surname><given-names>N.J.</given-names></name><name><surname>Steer</surname><given-names>A.</given-names></name><name><surname>Steiner</surname><given-names>T.</given-names></name><name><surname>Stolk</surname><given-names>W.A.</given-names></name><name><surname>Stovner</surname><given-names>L.J.</given-names></name><name><surname>Sudfeld</surname><given-names>C.</given-names></name><name><surname>Syed</surname><given-names>S.</given-names></name><name><surname>Tamburlini</surname><given-names>G.</given-names></name><name><surname>Tavakkoli</surname><given-names>M.</given-names></name><name><surname>Taylor</surname><given-names>H.R.</given-names></name><name><surname>Taylor</surname><given-names>J.A.</given-names></name><name><surname>Taylor</surname><given-names>W.J.</given-names></name><name><surname>Thomas</surname><given-names>B.</given-names></name><name><surname>Thomson</surname><given-names>W.M.</given-names></name><name><surname>Thurston</surname><given-names>G.D.</given-names></name><name><surname>Tleyjeh</surname><given-names>I.M.</given-names></name><name><surname>Tonelli</surname><given-names>M.</given-names></name><name><surname>Towbin</surname><given-names>J.A.</given-names></name><name><surname>Truelsen</surname><given-names>T.</given-names></name><name><surname>Tsilimbaris</surname><given-names>M.K.</given-names></name><name><surname>Ubeda</surname><given-names>C.</given-names></name><name><surname>Undurraga</surname><given-names>E.A.</given-names></name><name><surname>van der Werf</surname><given-names>M.J.</given-names></name><name><surname>van Os</surname><given-names>J.</given-names></name><name><surname>Vavilala</surname><given-names>M.S.</given-names></name><name><surname>Venketasubramanian</surname><given-names>N.</given-names></name><name><surname>Wang</surname><given-names>M.</given-names></name><name><surname>Wang</surname><given-names>W.</given-names></name><name><surname>Watt</surname><given-names>K.</given-names></name><name><surname>Weatherall</surname><given-names>D.J.</given-names></name><name><surname>Weinstock</surname><given-names>M.A.</given-names></name><name><surname>Weintraub</surname><given-names>R.</given-names></name><name><surname>Weisskopf</surname><given-names>M.G.</given-names></name><name><surname>Weissman</surname><given-names>M.M.</given-names></name><name><surname>White</surname><given-names>R.A.</given-names></name><name><surname>Whiteford</surname><given-names>H.</given-names></name><name><surname>Wiebe</surname><given-names>N.</given-names></name><name><surname>Wiersma</surname><given-names>S.T.</given-names></name><name><surname>Wilkinson</surname><given-names>J.D.</given-names></name><name><surname>Williams</surname><given-names>H.C.</given-names></name><name><surname>Williams</surname><given-names>S.R.</given-names></name><name><surname>Witt</surname><given-names>E.</given-names></name><name><surname>Wolfe</surname><given-names>F.</given-names></name><name><surname>Woolf</surname><given-names>A.D.</given-names></name><name><surname>Wulf</surname><given-names>S.</given-names></name><name><surname>Yeh</surname><given-names>P.H.</given-names></name><name><surname>Zaidi</surname><given-names>A.K.</given-names></name><name><surname>Zheng</surname><given-names>Z.J.</given-names></name><name><surname>Zonies</surname><given-names>D.</given-names></name><name><surname>Lopez</surname><given-names>A.D.</given-names></name></person-group><article-title>Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010</article-title><source>Lancet</source><volume>380</volume><year>2012</year><fpage>2197</fpage><lpage>2223</lpage><pub-id pub-id-type="pmid">23245608</pub-id></element-citation></ref><ref id="b0770"><element-citation publication-type="journal" id="h0770"><person-group person-group-type="author"><name><surname>Musgrave</surname><given-names>I.A.</given-names></name><name><surname>Hawes</surname><given-names>R.B.</given-names></name><name><surname>Jameson</surname><given-names>J.L.</given-names></name><name><surname>Sloane</surname><given-names>R.A.</given-names></name><name><surname>Quayle</surname><given-names>P.A.</given-names></name></person-group><article-title>Mebendazole – evaluation of a new antihelminthic for trichuriasis, hookworm, and strongyloidiasis</article-title><source>Med. J. Aust.</source><volume>1</volume><year>1979</year><fpage>403</fpage><lpage>405</lpage><pub-id pub-id-type="pmid">381876</pub-id></element-citation></ref><ref id="b0775"><element-citation publication-type="journal" id="h0775"><person-group person-group-type="author"><name><surname>Nfon</surname><given-names>C.K.</given-names></name><name><surname>Makepeace</surname><given-names>B.L.</given-names></name><name><surname>Njongmeta</surname><given-names>L.M.</given-names></name><name><surname>Tanya</surname><given-names>V.N.</given-names></name><name><surname>Trees</surname><given-names>A.J.</given-names></name></person-group><article-title>Lack of resistance after re-exposure of cattle cured of <italic>Onchocerca ocheng</italic>i infection with oxytetracycline</article-title><source>Am. J. Trop. Med. Hyg.</source><volume>76</volume><year>2007</year><fpage>67</fpage><lpage>72</lpage><pub-id pub-id-type="pmid">17255232</pub-id></element-citation></ref><ref id="b0780"><element-citation publication-type="journal" id="h0780"><person-group person-group-type="author"><name><surname>N’Goran</surname><given-names>E.K.</given-names></name><name><surname>Utzinger</surname><given-names>J.</given-names></name><name><surname>Gnaka</surname><given-names>H.N.</given-names></name><name><surname>Yapi</surname><given-names>A.</given-names></name><name><surname>N’Guessan</surname><given-names>N.A.</given-names></name><name><surname>Kigbafori</surname><given-names>S.D.</given-names></name><name><surname>Lengeler</surname><given-names>C.</given-names></name><name><surname>Chollet</surname><given-names>J.</given-names></name><name><surname>Shuhua</surname><given-names>X.</given-names></name><name><surname>Tanner</surname><given-names>M.</given-names></name></person-group><article-title>Randomized double-blind, placebo-controlled trial of oral artemether for the prevention of patent <italic>Schistosoma haematobium</italic> infections</article-title><source>Am. J. Trop. Med. Hyg.</source><volume>68</volume><year>2003</year><fpage>24</fpage><lpage>32</lpage><pub-id pub-id-type="pmid">12556143</pub-id></element-citation></ref><ref id="b0785"><element-citation publication-type="journal" id="h0785"><person-group person-group-type="author"><name><surname>O’Connor</surname><given-names>K.A.</given-names></name><name><surname>Roth</surname><given-names>B.L.</given-names></name></person-group><article-title>Finding new tricks for old drugs: an efficient route for public-sector drug discovery</article-title><source>Nat. Rev. Drug Dis.</source><volume>4</volume><year>2005</year><fpage>1005</fpage><lpage>1014</lpage></element-citation></ref><ref id="b0790"><element-citation publication-type="journal" id="h0790"><person-group person-group-type="author"><name><surname>Olliaro</surname><given-names>P.</given-names></name><name><surname>Seiler</surname><given-names>J.</given-names></name><name><surname>Kuesel</surname><given-names>A.</given-names></name><name><surname>Horton</surname><given-names>J.</given-names></name><name><surname>Clark</surname><given-names>J.N.</given-names></name><name><surname>Don</surname><given-names>R.</given-names></name><name><surname>Keiser</surname><given-names>J.</given-names></name></person-group><article-title>Potential drug development candidates for human soil-transmitted helminthiases</article-title><source>PLoS Negl. Trop. Dis.</source><volume>5</volume><year>2011</year><fpage>e1138</fpage><pub-id pub-id-type="pmid">21695247</pub-id></element-citation></ref><ref id="b0795"><element-citation publication-type="journal" id="h0795"><person-group person-group-type="author"><name><surname>Ortiz</surname><given-names>P.</given-names></name><name><surname>Terrones</surname><given-names>S.</given-names></name><name><surname>Cabrera</surname><given-names>M.</given-names></name><name><surname>Hoban</surname><given-names>C.</given-names></name><name><surname>Ceballos</surname><given-names>L.</given-names></name><name><surname>Moreno</surname><given-names>L.</given-names></name><name><surname>Canton</surname><given-names>C.</given-names></name><name><surname>Donadeu</surname><given-names>M.</given-names></name><name><surname>Lanusse</surname><given-names>C.</given-names></name><name><surname>Alvarez</surname><given-names>L.</given-names></name></person-group><article-title>Oxfendazole flukicidal activity in pigs</article-title><source>Acta Trop.</source><volume>136</volume><year>2014</year><fpage>10</fpage><lpage>13</lpage><pub-id pub-id-type="pmid">24713198</pub-id></element-citation></ref><ref id="b0800"><element-citation publication-type="journal" id="h0800"><person-group person-group-type="author"><name><surname>Padhy</surname><given-names>B.M.</given-names></name><name><surname>Gupta</surname><given-names>Y.K.</given-names></name></person-group><article-title>Drug repositioning: re-investigating existing drugs for new therapeutic indications</article-title><source>J. Postgrad. Med.</source><volume>57</volume><year>2011</year><fpage>153</fpage><lpage>160</lpage><pub-id pub-id-type="pmid">21654146</pub-id></element-citation></ref><ref id="b0805"><mixed-citation publication-type="other" id="h0805">Pawłowski, Z.S., Vuitton, D.A., Ammann, R.W., Kern, P., Craig, P.S., Dar, K.F., De Rosa, F., Filice, C., Gottstein, B., Grimm, F., Macpherson, C.N.L., Sato, N., Todorov, T., Uchino, J., von Sinner, W., Wen, H., 2001. Echinococcosis in humans: clinical aspects, diagnosis and treatment. In: Eckert, J., Gemmell, M., Meslin, F.-X., Pawlowski, Z., (Eds.), WHO/OIE Manual on Echinococcosis in Humans and Animals: a Public Health Problem of Global Concern World Organisation for Animal Health and World Health Organization, Paris, pp. 20–71.</mixed-citation></ref><ref id="b0810"><element-citation publication-type="journal" id="h0810"><person-group person-group-type="author"><name><surname>Pearson</surname><given-names>R.D.</given-names></name><name><surname>Hewlett</surname><given-names>E.L.</given-names></name></person-group><article-title>Niclosamide therapy for tapeworm infections</article-title><source>Ann. Intern. Med.</source><volume>102</volume><year>1985</year><fpage>550</fpage><lpage>551</lpage><pub-id pub-id-type="pmid">3977200</pub-id></element-citation></ref><ref id="b1315"><element-citation publication-type="journal" id="h1305"><person-group person-group-type="author"><name><surname>Pedrique</surname><given-names>B.</given-names></name><name><surname>Strub-Wourgaft</surname><given-names>N.</given-names></name><name><surname>Some</surname><given-names>C.</given-names></name><name><surname>Olliaro</surname><given-names>P.</given-names></name><name><surname>Trouiller</surname><given-names>P.</given-names></name><name><surname>Ford</surname><given-names>N.</given-names></name><name><surname>Pécoul</surname><given-names>B.</given-names></name><name><surname>Bradol</surname><given-names>J.-H.</given-names></name></person-group><article-title>The drug and vaccine landscape for neglected diseases (2000–11): a systematic assessment</article-title><source>The Lancet Global Health</source><volume>1</volume><year>2013</year><fpage>e371</fpage><lpage>e379</lpage><pub-id pub-id-type="pmid">25104602</pub-id></element-citation></ref><ref id="b0820"><element-citation publication-type="journal" id="h0820"><person-group person-group-type="author"><name><surname>Perez-Molina</surname><given-names>J.A.</given-names></name><name><surname>Diaz-Menendez</surname><given-names>M.</given-names></name><name><surname>Gallego</surname><given-names>J.I.</given-names></name><name><surname>Norman</surname><given-names>F.</given-names></name><name><surname>Monge-Maillo</surname><given-names>B.</given-names></name><name><surname>Ayala</surname><given-names>A.P.</given-names></name><name><surname>Lopez-Velez</surname><given-names>R.</given-names></name></person-group><article-title>Evaluation of nitazoxanide for the treatment of disseminated cystic echinococcosis: report of five cases and literature review</article-title><source>Am. J. Trop. Med. Hyg.</source><volume>84</volume><year>2011</year><fpage>351</fpage><lpage>356</lpage><pub-id pub-id-type="pmid">21292913</pub-id></element-citation></ref><ref id="b0825"><element-citation publication-type="journal" id="h0825"><person-group person-group-type="author"><name><surname>Perez del Villar</surname><given-names>L.</given-names></name><name><surname>Burguillo</surname><given-names>F.J.</given-names></name><name><surname>Lopez-Aban</surname><given-names>J.</given-names></name><name><surname>Muro</surname><given-names>A.</given-names></name></person-group><article-title>Systematic review and meta-analysis of artemisinin based therapies for the treatment and prevention of schistosomiasis</article-title><source>PLoS One</source><volume>7</volume><year>2012</year><fpage>e45867</fpage><pub-id pub-id-type="pmid">23029285</pub-id></element-citation></ref><ref id="b0830"><element-citation publication-type="journal" id="h0830"><person-group person-group-type="author"><name><surname>Qian</surname><given-names>M.B.</given-names></name><name><surname>Yap</surname><given-names>P.</given-names></name><name><surname>Yang</surname><given-names>Y.C.</given-names></name><name><surname>Liang</surname><given-names>H.</given-names></name><name><surname>Jiang</surname><given-names>Z.H.</given-names></name><name><surname>Li</surname><given-names>W.</given-names></name><name><surname>Tan</surname><given-names>Y.G.</given-names></name><name><surname>Zhou</surname><given-names>H.</given-names></name><name><surname>Utzinger</surname><given-names>J.</given-names></name><name><surname>Zhou</surname><given-names>X.N.</given-names></name><name><surname>Keiser</surname><given-names>J.</given-names></name></person-group><article-title>Efficacy and safety of tribendimidine against <italic>Clonorchis sinensis</italic></article-title><source>Clin. Infect. Dis.</source><volume>56</volume><year>2013</year><fpage>e76</fpage><lpage>82</lpage><pub-id pub-id-type="pmid">23223597</pub-id></element-citation></ref><ref id="b0835"><element-citation publication-type="journal" id="h0835"><person-group person-group-type="author"><name><surname>Ranjan</surname><given-names>S.</given-names></name><name><surname>DeLay</surname><given-names>R.</given-names></name></person-group><article-title>Therapeutic and persistent efficacy of moxidectin 1% nonaqueous injectable formulation against natural and experimentally induced lung and gastrointestinal nematodes in cattle</article-title><source>Vet. Parasitol.</source><volume>120</volume><year>2004</year><fpage>305</fpage><lpage>317</lpage><pub-id pub-id-type="pmid">15063941</pub-id></element-citation></ref><ref id="b1260"><element-citation publication-type="journal" id="h1250"><person-group person-group-type="author"><name><surname>Rao</surname><given-names>R.U.</given-names></name><name><surname>Huang</surname><given-names>Y.</given-names></name><name><surname>Fischer</surname><given-names>K.</given-names></name><name><surname>Fischer</surname><given-names>P.U.</given-names></name><name><surname>Weil</surname><given-names>G.J.</given-names></name></person-group><article-title><italic>Brugia malayi</italic>: effects of nitazoxanide and tizoxanide on adult worms and microfilariae of filarial nematodes</article-title><source>Exp. Parasitol.</source><volume>121</volume><year>2009</year><fpage>38</fpage><lpage>45</lpage><pub-id pub-id-type="pmid">18977224</pub-id></element-citation></ref><ref id="b1265"><element-citation publication-type="journal" id="h1255"><person-group person-group-type="author"><name><surname>Reichard</surname><given-names>M.V.</given-names></name><name><surname>Wolf</surname><given-names>R.F.</given-names></name><name><surname>Carey</surname><given-names>D.W.</given-names></name><name><surname>Garrett</surname><given-names>J.J.</given-names></name><name><surname>Briscoe</surname><given-names>H.A.</given-names></name></person-group><article-title>Efficacy of fenbendazole and milbemycin oxime for treating baboons (<italic>Papio cynocephalus anubis</italic>) infected with <italic>Trichuris trichiura</italic></article-title><source>J. Am. Assoc. Lab. Anim. Sci.</source><volume>46</volume><year>2007</year><fpage>42</fpage><lpage>45</lpage><pub-id pub-id-type="pmid">17343352</pub-id></element-citation></ref><ref id="b0850"><element-citation publication-type="journal" id="h0850"><person-group person-group-type="author"><name><surname>Reinemeyer</surname><given-names>C.R.</given-names></name><name><surname>Cleale</surname><given-names>R.M.</given-names></name></person-group><article-title>Dose confirmation studies of moxidectin 1% non-aqueous injectable and moxidectin 0.5% pour-on formulations against experimentally induced infections of larval and adult stage <italic>Oesophagostomum radiatum</italic> and <italic>Trichuris discolor</italic> in cattle</article-title><source>Vet. Parasitol.</source><volume>108</volume><year>2002</year><fpage>75</fpage><lpage>83</lpage><pub-id pub-id-type="pmid">12191901</pub-id></element-citation></ref><ref id="b0855"><element-citation publication-type="journal" id="h0855"><person-group person-group-type="author"><name><surname>Reuter</surname><given-names>S.</given-names></name><name><surname>Buck</surname><given-names>A.</given-names></name><name><surname>Grebe</surname><given-names>O.</given-names></name><name><surname>Nussle-Kugele</surname><given-names>K.</given-names></name><name><surname>Kern</surname><given-names>P.</given-names></name><name><surname>Manfras</surname><given-names>B.J.</given-names></name></person-group><article-title>Salvage treatment with amphotericin B in progressive human alveolar echinococcosis</article-title><source>Antimicrob. Agents Chemother.</source><volume>47</volume><year>2003</year><fpage>3586</fpage><lpage>3591</lpage><pub-id pub-id-type="pmid">14576122</pub-id></element-citation></ref><ref id="b0860"><element-citation publication-type="journal" id="h0860"><person-group person-group-type="author"><name><surname>Reuter</surname><given-names>S.</given-names></name><name><surname>Merkle</surname><given-names>M.</given-names></name><name><surname>Brehm</surname><given-names>K.</given-names></name><name><surname>Kern</surname><given-names>P.</given-names></name><name><surname>Manfras</surname><given-names>B.</given-names></name></person-group><article-title>Effect of amphotericin B on larval growth of <italic>Echinococcus multilocularis</italic></article-title><source>Antimicrob. Agents Chemother.</source><volume>47</volume><year>2003</year><fpage>620</fpage><lpage>625</lpage><pub-id pub-id-type="pmid">12543669</pub-id></element-citation></ref><ref id="b0865"><element-citation publication-type="journal" id="h0865"><person-group person-group-type="author"><name><surname>Reuter</surname><given-names>S.</given-names></name><name><surname>Manfras</surname><given-names>B.</given-names></name><name><surname>Merkle</surname><given-names>M.</given-names></name><name><surname>Harter</surname><given-names>G.</given-names></name><name><surname>Kern</surname><given-names>P.</given-names></name></person-group><article-title><italic>In vitro</italic> activities of itraconazole, methiazole, and nitazoxanide versus <italic>Echinococcus multilocularis</italic> larvae</article-title><source>Antimicrob. Agents Chemother.</source><volume>50</volume><year>2006</year><fpage>2966</fpage><lpage>2970</lpage><pub-id pub-id-type="pmid">16940089</pub-id></element-citation></ref><ref id="b0870"><element-citation publication-type="journal" id="h0870"><person-group person-group-type="author"><name><surname>Richards</surname><given-names>F.O.</given-names><suffix>Jr.</suffix></name><name><surname>Amann</surname><given-names>J.</given-names></name><name><surname>Arana</surname><given-names>B.</given-names></name><name><surname>Punkosdy</surname><given-names>G.</given-names></name><name><surname>Klein</surname><given-names>R.</given-names></name><name><surname>Blanco</surname><given-names>C.</given-names></name><name><surname>Lopez</surname><given-names>B.</given-names></name><name><surname>Mendoza</surname><given-names>C.</given-names></name><name><surname>Dominguez</surname><given-names>A.</given-names></name><name><surname>Guarner</surname><given-names>J.</given-names></name><name><surname>Maguire</surname><given-names>J.H.</given-names></name><name><surname>Eberhard</surname><given-names>M.</given-names></name></person-group><article-title>No depletion of Wolbachia from <italic>Onchocerca volvulus</italic> after a short course of rifampin and/or azithromycin</article-title><source>Am. J. Trop. Med. Hyg.</source><volume>77</volume><year>2007</year><fpage>878</fpage><lpage>882</lpage><pub-id pub-id-type="pmid">17984346</pub-id></element-citation></ref><ref id="b0875"><element-citation publication-type="journal" id="h0875"><person-group person-group-type="author"><name><surname>Richter</surname><given-names>D.</given-names></name><name><surname>Richter</surname><given-names>J.</given-names></name><name><surname>Gruner</surname><given-names>B.</given-names></name><name><surname>Kranz</surname><given-names>K.</given-names></name><name><surname>Franz</surname><given-names>J.</given-names></name><name><surname>Kern</surname><given-names>P.</given-names></name></person-group><article-title><italic>In vitro</italic> efficacy of triclabendazole and clorsulon against the larval stage of <italic>Echinococcus multilocularis</italic></article-title><source>Parasitol. Res.</source><volume>112</volume><year>2013</year><fpage>1655</fpage><lpage>1660</lpage><pub-id pub-id-type="pmid">23455934</pub-id></element-citation></ref><ref id="b0880"><element-citation publication-type="journal" id="h0880"><person-group person-group-type="author"><name><surname>Rim</surname><given-names>H.J.</given-names></name><name><surname>Lee</surname><given-names>J.S.</given-names></name><name><surname>Joo</surname><given-names>K.H.</given-names></name><name><surname>Kim</surname><given-names>Y.S.</given-names></name></person-group><article-title>Anthelmintic effects of single doses of fenbendazole and oxantel-pyrantel pamoate to the intestinal nematodes</article-title><source>Korean J. Parasitol.</source><volume>19</volume><year>1981</year><fpage>95</fpage><lpage>100</lpage></element-citation></ref><ref id="b0885"><element-citation publication-type="journal" id="h0885"><person-group person-group-type="author"><name><surname>Romero Cabello</surname><given-names>R.</given-names></name><name><surname>Guerrero</surname><given-names>L.R.</given-names></name><name><surname>Munoz Garcia</surname><given-names>M.R.</given-names></name><name><surname>Geyne Cruz</surname><given-names>A.</given-names></name></person-group><article-title>Nitazoxanide for the treatment of intestinal protozoan and helminthic infections in Mexico</article-title><source>Trans. R. Soc. Trop. Med. Hyg.</source><volume>91</volume><year>1997</year><fpage>701</fpage><lpage>703</lpage><pub-id pub-id-type="pmid">9580117</pub-id></element-citation></ref><ref id="b0890"><element-citation publication-type="journal" id="h0890"><person-group person-group-type="author"><name><surname>Rossignol</surname><given-names>J.F.</given-names></name></person-group><article-title>Thiazolides: a new class of antiviral drugs</article-title><source>Expert Opin. Drug Metab. Toxicol.</source><volume>5</volume><year>2009</year><fpage>667</fpage><lpage>674</lpage><pub-id pub-id-type="pmid">19442032</pub-id></element-citation></ref><ref id="b0895"><element-citation publication-type="journal" id="h0895"><person-group person-group-type="author"><name><surname>Rossignol</surname><given-names>J.F.</given-names></name><name><surname>Maisonneuve</surname><given-names>H.</given-names></name></person-group><article-title>Nitazoxanide in the treatment of <italic>Taenia saginata</italic> and <italic>Hymenolepis nana</italic> infections</article-title><source>Am. J. Trop. Med. Hyg.</source><volume>33</volume><year>1984</year><fpage>511</fpage><lpage>512</lpage><pub-id pub-id-type="pmid">6731683</pub-id></element-citation></ref><ref id="b0900"><element-citation publication-type="journal" id="h0900"><person-group person-group-type="author"><name><surname>Saeki</surname><given-names>H.</given-names></name><name><surname>Ishii</surname><given-names>T.</given-names></name><name><surname>Ohta</surname><given-names>M.</given-names></name><name><surname>Tsuchiya</surname><given-names>S.</given-names></name><name><surname>Furuya</surname><given-names>T.</given-names></name><name><surname>Fujii</surname><given-names>T.</given-names></name></person-group><article-title>Evaluation of anthelmintic efficacy of doramectin against gastrointestinal nematodes by fecal examination in cattle in Japan</article-title><source>J. Vet. Med. Sci.</source><volume>57</volume><year>1995</year><fpage>1057</fpage><lpage>1061</lpage><pub-id pub-id-type="pmid">8720047</pub-id></element-citation></ref><ref id="b0905"><element-citation publication-type="journal" id="h0905"><person-group person-group-type="author"><name><surname>Salem</surname><given-names>H.H.</given-names></name><name><surname>el-Allaf</surname><given-names>G.</given-names></name></person-group><article-title>Treatment of <italic>Taenia saginata</italic> and <italic>Hymenolepis nana</italic> infections with paromomycin</article-title><source>Trans. R. Soc. Trop. Med. Hyg.</source><volume>63</volume><year>1969</year><fpage>833</fpage><lpage>836</lpage><pub-id pub-id-type="pmid">5368012</pub-id></element-citation></ref><ref id="b0910"><element-citation publication-type="journal" id="h0910"><person-group person-group-type="author"><name><surname>Sanchez-Carrillo</surname><given-names>M.C.</given-names></name><name><surname>Beltran-Hernandez</surname><given-names>F.</given-names></name></person-group><article-title>Therapeutic effectiveness of fenbendazole (HOE-881) in helminthiasis transmitted by the soil in the state of Chiapas, Mexico</article-title><source>Salud Publica Mex.</source><volume>19</volume><year>1977</year><fpage>691</fpage><lpage>700</lpage><pub-id pub-id-type="pmid">615631</pub-id></element-citation></ref><ref id="b0915"><element-citation publication-type="journal" id="h0915"><person-group person-group-type="author"><name><surname>Schad</surname><given-names>G.A.</given-names></name></person-group><article-title>Cyclosporine may eliminate the threat of overwhelming strongyloidiasis in immunosuppressed patients</article-title><source>J. Infect. Dis.</source><volume>153</volume><year>1986</year><fpage>178</fpage><pub-id pub-id-type="pmid">3941286</pub-id></element-citation></ref><ref id="b0920"><element-citation publication-type="journal" id="h0920"><person-group person-group-type="author"><name><surname>Sekhon</surname><given-names>B.S.</given-names></name></person-group><article-title>Repositioning drugs and biologics: Retargeting old/existing drugs for potential new therapeutic applications</article-title><source>J. Pharm. Educ. Res.</source><volume>4</volume><year>2013</year><fpage>1</fpage><lpage>15</lpage></element-citation></ref><ref id="b0925"><element-citation publication-type="journal" id="h0925"><person-group person-group-type="author"><name><surname>Shikiya</surname><given-names>K.</given-names></name><name><surname>Kuniyoshi</surname><given-names>T.</given-names></name><name><surname>Higashionna</surname><given-names>A.</given-names></name><name><surname>Arakkaki</surname><given-names>T.</given-names></name><name><surname>Oyakawa</surname><given-names>T.</given-names></name><name><surname>Kadena</surname><given-names>K.</given-names></name><name><surname>Kinjo</surname><given-names>F.</given-names></name><name><surname>Saito</surname><given-names>A.</given-names></name><name><surname>Asato</surname><given-names>R.</given-names></name></person-group><article-title>Treatment of strongyloidiasis with mebendazole and its combination with thiabendazole. Kansenshogaku zasshi</article-title><source>J. Jpn. Assoc. Infect. Dis.</source><volume>64</volume><year>1990</year><fpage>1408</fpage><lpage>1415</lpage></element-citation></ref><ref id="b0930"><element-citation publication-type="journal" id="h0930"><person-group person-group-type="author"><name><surname>Shikiya</surname><given-names>K.</given-names></name><name><surname>Kinjo</surname><given-names>N.</given-names></name><name><surname>Ikema</surname><given-names>M.</given-names></name><name><surname>Yamashiro</surname><given-names>A.</given-names></name><name><surname>Uechi</surname><given-names>H.</given-names></name><name><surname>Oyakawa</surname><given-names>T.</given-names></name><name><surname>Kinjo</surname><given-names>F.</given-names></name><name><surname>Saito</surname><given-names>A.</given-names></name><name><surname>Nakamura</surname><given-names>H.</given-names></name><name><surname>Ohwan</surname><given-names>T.</given-names></name></person-group><article-title>Comparison of efficacy of powder and tablet of mebendazole in the treatment of strongyloidiasis. Kansenshogaku zasshi</article-title><source>J. Jpn. Assoc. Infect. Dis.</source><volume>65</volume><year>1991</year><fpage>681</fpage><lpage>686</lpage></element-citation></ref><ref id="b0935"><element-citation publication-type="journal" id="h0935"><person-group person-group-type="author"><name><surname>Soo</surname><given-names>G.W.</given-names></name><name><surname>Law</surname><given-names>J.H.</given-names></name><name><surname>Kan</surname><given-names>E.</given-names></name><name><surname>Tan</surname><given-names>S.Y.</given-names></name><name><surname>Lim</surname><given-names>W.Y.</given-names></name><name><surname>Chay</surname><given-names>G.</given-names></name><name><surname>Bukhari</surname><given-names>N.I.</given-names></name><name><surname>Segarra</surname><given-names>I.</given-names></name></person-group><article-title>Differential effects of ketoconazole and primaquine on the pharmacokinetics and tissue distribution of imatinib in mice</article-title><source>Anticancer Drugs</source><volume>7</volume><year>2010</year><fpage>695</fpage><lpage>703</lpage><pub-id pub-id-type="pmid">20629201</pub-id></element-citation></ref><ref id="b0940"><element-citation publication-type="journal" id="h0940"><person-group person-group-type="author"><name><surname>Sotelo</surname><given-names>J.</given-names></name><name><surname>Escobedo</surname><given-names>F.</given-names></name><name><surname>Penagos</surname><given-names>P.</given-names></name></person-group><article-title>Albendazole vs praziquantel for therapy for neurocysticercosis. A controlled trial</article-title><source>Arch. Neurol.</source><volume>45</volume><year>1988</year><fpage>532</fpage><lpage>534</lpage><pub-id pub-id-type="pmid">3358706</pub-id></element-citation></ref><ref id="b0945"><element-citation publication-type="journal" id="h0945"><person-group person-group-type="author"><name><surname>Sotelo</surname><given-names>J.</given-names></name><name><surname>del Brutto</surname><given-names>O.H.</given-names></name><name><surname>Penagos</surname><given-names>P.</given-names></name><name><surname>Escobedo</surname><given-names>F.</given-names></name><name><surname>Torres</surname><given-names>B.</given-names></name><name><surname>Rodriguez-Carbajal</surname><given-names>J.</given-names></name><name><surname>Rubio-Donnadieu</surname><given-names>F.</given-names></name></person-group><article-title>Comparison of therapeutic regimen of anticysticercal drugs for parenchymal brain cysticercosis</article-title><source>J. Neurol.</source><volume>237</volume><year>1990</year><fpage>69</fpage><lpage>72</lpage><pub-id pub-id-type="pmid">2192018</pub-id></element-citation></ref><ref id="b0950"><element-citation publication-type="journal" id="h0950"><person-group person-group-type="author"><name><surname>Soukhathammavong</surname><given-names>P.</given-names></name><name><surname>Odermatt</surname><given-names>P.</given-names></name><name><surname>Sayasone</surname><given-names>S.</given-names></name><name><surname>Vonghachack</surname><given-names>Y.</given-names></name><name><surname>Vounatsou</surname><given-names>P.</given-names></name><name><surname>Hatz</surname><given-names>C.</given-names></name><name><surname>Akkhavong</surname><given-names>K.</given-names></name><name><surname>Keiser</surname><given-names>J.</given-names></name></person-group><article-title>Efficacy and safety of mefloquine, artesunate, mefloquine-artesunate, tribendimidine, and praziquantel in patients with <italic>Opisthorchis viverrini</italic>: a randomised, exploratory, open-label, phase 2 trial</article-title><source>Lancet Infect. Dis.</source><volume>11</volume><year>2011</year><fpage>110</fpage><lpage>118</lpage><pub-id pub-id-type="pmid">21111681</pub-id></element-citation></ref><ref id="b0955"><element-citation publication-type="journal" id="h0955"><person-group person-group-type="author"><name><surname>Specht</surname><given-names>S.</given-names></name><name><surname>Mand</surname><given-names>S.</given-names></name><name><surname>Marfo-Debrekyei</surname><given-names>Y.</given-names></name><name><surname>Debrah</surname><given-names>A.Y.</given-names></name><name><surname>Konadu</surname><given-names>P.</given-names></name><name><surname>Adjei</surname><given-names>O.</given-names></name><name><surname>Buttner</surname><given-names>D.W.</given-names></name><name><surname>Hoerauf</surname><given-names>A.</given-names></name></person-group><article-title>Efficacy of 2- and 4-week rifampicin treatment on the Wolbachia of <italic>Onchocerca volvulus</italic></article-title><source>Parasitol. Res.</source><volume>103</volume><year>2008</year><fpage>1303</fpage><lpage>1309</lpage><pub-id pub-id-type="pmid">18679718</pub-id></element-citation></ref><ref id="b0960"><element-citation publication-type="journal" id="h0960"><person-group person-group-type="author"><name><surname>Speich</surname><given-names>B.</given-names></name><name><surname>Ame</surname><given-names>S.M.</given-names></name><name><surname>Ali</surname><given-names>S.M.</given-names></name><name><surname>Alles</surname><given-names>R.</given-names></name><name><surname>Hattendorf</surname><given-names>J.</given-names></name><name><surname>Utzinger</surname><given-names>J.R.</given-names></name><name><surname>Albonico</surname><given-names>M.</given-names></name><name><surname>Keiser</surname><given-names>J.</given-names></name></person-group><article-title>Efficacy and safety of nitazoxanide, albendazole, and nitazoxanide-albendazole against <italic>Trichuris trichiura</italic> infection: a randomized controlled trial</article-title><source>PLoS Negl. Trop. Dis.</source><volume>6</volume><year>2012</year><fpage>e1685</fpage><pub-id pub-id-type="pmid">22679525</pub-id></element-citation></ref><ref id="b0965"><element-citation publication-type="journal" id="h0965"><person-group person-group-type="author"><name><surname>Speich</surname><given-names>B.</given-names></name><name><surname>Marti</surname><given-names>H.</given-names></name><name><surname>Ame</surname><given-names>S.M.</given-names></name><name><surname>Ali</surname><given-names>S.M.</given-names></name><name><surname>Bogoch</surname><given-names>I.I.</given-names></name><name><surname>Utzinger</surname><given-names>J.</given-names></name><name><surname>Albonico</surname><given-names>M.</given-names></name><name><surname>Keiser</surname><given-names>J.</given-names></name></person-group><article-title>Prevalence of intestinal protozoa infection among school-aged children on Pemba Island, Tanzania, and effect of single-dose albendazole, nitazoxanide and albendazole-nitazoxanide</article-title><source>Parasite Vectors</source><volume>6</volume><year>2013</year><fpage>3</fpage></element-citation></ref><ref id="b0970"><element-citation publication-type="journal" id="h0970"><person-group person-group-type="author"><name><surname>Speich</surname><given-names>B.</given-names></name><name><surname>Ame</surname><given-names>S.M.</given-names></name><name><surname>Ali</surname><given-names>S.M.</given-names></name><name><surname>Alles</surname><given-names>R.</given-names></name><name><surname>Huwyler</surname><given-names>J.</given-names></name><name><surname>Hattendorf</surname><given-names>J.</given-names></name><name><surname>Utzinger</surname><given-names>J.</given-names></name><name><surname>Albonico</surname><given-names>M.</given-names></name><name><surname>Keiser</surname><given-names>J.</given-names></name></person-group><article-title>Oxantel pamoate-albendazole for <italic>Trichuris trichiura</italic> infection</article-title><source>New Engl. J. Med.</source><volume>370</volume><year>2014</year><fpage>610</fpage><lpage>620</lpage><pub-id pub-id-type="pmid">24521107</pub-id></element-citation></ref><ref id="b0975"><element-citation publication-type="journal" id="h0975"><person-group person-group-type="author"><name><surname>Spicher</surname><given-names>M.</given-names></name><name><surname>Roethlisberger</surname><given-names>C.</given-names></name><name><surname>Lany</surname><given-names>C.</given-names></name><name><surname>Stadelmann</surname><given-names>B.</given-names></name><name><surname>Keiser</surname><given-names>J.</given-names></name><name><surname>Ortega-Mora</surname><given-names>L.M.</given-names></name><name><surname>Gottstein</surname><given-names>B.</given-names></name><name><surname>Hemphill</surname><given-names>A.</given-names></name></person-group><article-title><italic>In vitro</italic> and <italic>in vivo</italic> treatments of echinococcus protoscoleces and metacestodes with artemisinin and artemisinin derivatives</article-title><source>Antimicrob. Agents Chemother.</source><volume>52</volume><year>2008</year><fpage>3447</fpage><lpage>3450</lpage><pub-id pub-id-type="pmid">18625777</pub-id></element-citation></ref><ref id="b1270"><element-citation publication-type="journal" id="h1260"><person-group person-group-type="author"><name><surname>Steinmann</surname><given-names>P.</given-names></name><name><surname>Zhou</surname><given-names>X.N.</given-names></name><name><surname>Du</surname><given-names>Z.W.</given-names></name><name><surname>Jiang</surname><given-names>J.Y.</given-names></name><name><surname>Xiao</surname><given-names>S.H.</given-names></name><name><surname>Wu</surname><given-names>Z.X.</given-names></name><name><surname>Zhou</surname><given-names>H.</given-names></name><name><surname>Utzinger</surname><given-names>J.</given-names></name></person-group><article-title>Tribendimidine and albendazole for treating soil-transmitted helminths, Strongyloides stercoralis and <italic>Taenia</italic> spp.: open-label randomized trial</article-title><source>PLoS Negl. Trop. Dis.</source><volume>2</volume><year>2008</year><fpage>e322</fpage><pub-id pub-id-type="pmid">18923706</pub-id></element-citation></ref><ref id="b0985"><element-citation publication-type="journal" id="h0985"><person-group person-group-type="author"><name><surname>Stettler</surname><given-names>M.</given-names></name><name><surname>Fink</surname><given-names>R.</given-names></name><name><surname>Walker</surname><given-names>M.</given-names></name><name><surname>Gottstein</surname><given-names>B.</given-names></name><name><surname>Geary</surname><given-names>T.G.</given-names></name><name><surname>Rossignol</surname><given-names>J.F.</given-names></name><name><surname>Hemphill</surname><given-names>A.</given-names></name></person-group><article-title><italic>In vitro</italic> parasiticidal effect of nitazoxanide against <italic>Echinococcus multilocularis</italic> metacestodes</article-title><source>Antimicrob. Agents Chemother.</source><volume>47</volume><year>2003</year><fpage>467</fpage><lpage>474</lpage><pub-id pub-id-type="pmid">12543645</pub-id></element-citation></ref><ref id="b0990"><element-citation publication-type="journal" id="h0990"><person-group person-group-type="author"><name><surname>Stettler</surname><given-names>M.</given-names></name><name><surname>Rossignol</surname><given-names>J.F.</given-names></name><name><surname>Fink</surname><given-names>R.</given-names></name><name><surname>Walker</surname><given-names>M.</given-names></name><name><surname>Gottstein</surname><given-names>B.</given-names></name><name><surname>Merli</surname><given-names>M.</given-names></name><name><surname>Theurillat</surname><given-names>R.</given-names></name><name><surname>Thormann</surname><given-names>W.</given-names></name><name><surname>Dricot</surname><given-names>E.</given-names></name><name><surname>Segers</surname><given-names>R.</given-names></name><name><surname>Hemphill</surname><given-names>A.</given-names></name></person-group><article-title>Secondary and primary murine alveolar echinococcosis: combined albendazole/nitazoxanide chemotherapy exhibits profound anti-parasitic activity</article-title><source>Int. J. Parasitol.</source><volume>34</volume><year>2004</year><fpage>615</fpage><lpage>624</lpage><pub-id pub-id-type="pmid">15064126</pub-id></element-citation></ref><ref id="b0995"><element-citation publication-type="journal" id="h0995"><person-group person-group-type="author"><name><surname>Stewart</surname><given-names>T.B.</given-names></name><name><surname>Fox</surname><given-names>M.C.</given-names></name><name><surname>Wiles</surname><given-names>S.E.</given-names></name></person-group><article-title>Doramectin efficacy against gastrointestinal nematodes in pigs</article-title><source>Vet. Parasitol.</source><volume>66</volume><year>1996</year><fpage>101</fpage><lpage>108</lpage><pub-id pub-id-type="pmid">8988561</pub-id></element-citation></ref><ref id="b1000"><element-citation publication-type="journal" id="h1000"><person-group person-group-type="author"><name><surname>Stewart</surname><given-names>T.B.</given-names></name><name><surname>Wiles</surname><given-names>S.E.</given-names></name><name><surname>Miller</surname><given-names>J.E.</given-names></name><name><surname>Rulli</surname><given-names>R.D.</given-names></name></person-group><article-title>Efficacy of moxidectin 0.5% pour-on against swine nematodes</article-title><source>Vet. Parasitol.</source><volume>87</volume><year>1999</year><fpage>39</fpage><lpage>44</lpage><pub-id pub-id-type="pmid">10628698</pub-id></element-citation></ref><ref id="b1005"><element-citation publication-type="journal" id="h1005"><person-group person-group-type="author"><name><surname>Stothard</surname><given-names>J.R.</given-names></name><name><surname>Sousa-Figueiredo</surname><given-names>J.C.</given-names></name><name><surname>Betson</surname><given-names>M.</given-names></name><name><surname>Bustinduy</surname><given-names>A.</given-names></name><name><surname>Reinhard-Rupp</surname><given-names>J.</given-names></name></person-group><article-title>Schistosomiasis in African infants and preschool children: let them now be treated!</article-title><source>Trends Parasitol.</source><volume>29</volume><year>2013</year><fpage>197</fpage><lpage>205</lpage><pub-id pub-id-type="pmid">23465781</pub-id></element-citation></ref><ref id="b1010"><element-citation publication-type="journal" id="h1010"><person-group person-group-type="author"><name><surname>Supali</surname><given-names>T.</given-names></name><name><surname>Djuardi</surname><given-names>Y.</given-names></name><name><surname>Pfarr</surname><given-names>K.M.</given-names></name><name><surname>Wibowo</surname><given-names>H.</given-names></name><name><surname>Taylor</surname><given-names>M.J.</given-names></name><name><surname>Hoerauf</surname><given-names>A.</given-names></name><name><surname>Houwing-Duistermaat</surname><given-names>J.J.</given-names></name><name><surname>Yazdanbakhsh</surname><given-names>M.</given-names></name><name><surname>Sartono</surname><given-names>E.</given-names></name></person-group><article-title>Doxycycline treatment of <italic>Brugia malayi</italic>-infected persons reduces microfilaremia and adverse reactions after diethylcarbamazine and albendazole treatment</article-title><source>Clin. Infect. Dis.</source><volume>46</volume><year>2008</year><fpage>1385</fpage><lpage>1393</lpage><pub-id pub-id-type="pmid">18419441</pub-id></element-citation></ref><ref id="b1015"><element-citation publication-type="journal" id="h1015"><person-group person-group-type="author"><name><surname>Takayanagui</surname><given-names>O.M.</given-names></name><name><surname>Jardim</surname><given-names>E.</given-names></name></person-group><article-title>Therapy for neurocysticercosis. Comparison between albendazole and praziquantel</article-title><source>Arch. Neurol.</source><volume>49</volume><year>1992</year><fpage>290</fpage><lpage>294</lpage><pub-id pub-id-type="pmid">1536632</pub-id></element-citation></ref><ref id="b1020"><element-citation publication-type="journal" id="h1020"><person-group person-group-type="author"><name><surname>Taylor</surname><given-names>M.J.</given-names></name><name><surname>Makunde</surname><given-names>W.H.</given-names></name><name><surname>McGarry</surname><given-names>H.F.</given-names></name><name><surname>Turner</surname><given-names>J.D.</given-names></name><name><surname>Mand</surname><given-names>S.</given-names></name><name><surname>Hoerauf</surname><given-names>A.</given-names></name></person-group><article-title>Macrofilaricidal activity after doxycycline treatment of <italic>Wuchereria bancrofti</italic>: a double-blind, randomised placebo-controlled trial</article-title><source>Lancet</source><volume>365</volume><year>2005</year><fpage>2116</fpage><lpage>2121</lpage><pub-id pub-id-type="pmid">15964448</pub-id></element-citation></ref><ref id="b1025"><element-citation publication-type="journal" id="h1025"><person-group person-group-type="author"><name><surname>Taylor</surname><given-names>M.J.</given-names></name><name><surname>Awadzi</surname><given-names>K.</given-names></name><name><surname>Basanez</surname><given-names>M.G.</given-names></name><name><surname>Biritwum</surname><given-names>N.</given-names></name><name><surname>Boakye</surname><given-names>D.</given-names></name><name><surname>Boatin</surname><given-names>B.</given-names></name><name><surname>Bockarie</surname><given-names>M.</given-names></name><name><surname>Churcher</surname><given-names>T.S.</given-names></name><name><surname>Debrah</surname><given-names>A.</given-names></name><name><surname>Edwards</surname><given-names>G.</given-names></name><name><surname>Hoerauf</surname><given-names>A.</given-names></name><name><surname>Mand</surname><given-names>S.</given-names></name><name><surname>Matthews</surname><given-names>G.</given-names></name><name><surname>Osei-Atweneboana</surname><given-names>M.</given-names></name><name><surname>Prichard</surname><given-names>R.K.</given-names></name><name><surname>Wanji</surname><given-names>S.</given-names></name><name><surname>Adjei</surname><given-names>O.</given-names></name></person-group><article-title>Onchocerciasis control: vision for the future from a Ghanian perspective</article-title><source>Parasit. Vectors</source><volume>2</volume><year>2009</year><fpage>7</fpage><pub-id pub-id-type="pmid">19154624</pub-id></element-citation></ref><ref id="b1030"><element-citation publication-type="journal" id="h1030"><person-group person-group-type="author"><name><surname>Terrazas</surname><given-names>L.I.</given-names></name><name><surname>Bojalil</surname><given-names>R.</given-names></name><name><surname>Govezensky</surname><given-names>T.</given-names></name><name><surname>Larralde</surname><given-names>C.</given-names></name></person-group><article-title>A role for 17-beta-estradiol in immunoendocrine regulation of murine cysticercosis (Taenia crassiceps)</article-title><source>J. Parasitol.</source><volume>80</volume><year>1994</year><fpage>563</fpage><lpage>568</lpage><pub-id pub-id-type="pmid">8064524</pub-id></element-citation></ref><ref id="b1035"><element-citation publication-type="journal" id="h1035"><person-group person-group-type="author"><name><surname>Toh</surname><given-names>S.Q.</given-names></name><name><surname>Glanfield</surname><given-names>A.</given-names></name><name><surname>Gobert</surname><given-names>G.N.</given-names></name><name><surname>Jones</surname><given-names>M.K.</given-names></name></person-group><article-title>Heme and blood-feeding parasites: friends or foes?</article-title><source>Parasit. Vectors</source><volume>3</volume><year>2010</year><fpage>108</fpage><pub-id pub-id-type="pmid">21087517</pub-id></element-citation></ref><ref id="b1040"><element-citation publication-type="journal" id="h1040"><person-group person-group-type="author"><name><surname>Topcu</surname><given-names>O.</given-names></name><name><surname>Sumer</surname><given-names>Z.</given-names></name><name><surname>Tuncer</surname><given-names>E.</given-names></name><name><surname>Aydin</surname><given-names>C.</given-names></name><name><surname>Koyuncu</surname><given-names>A.</given-names></name></person-group><article-title>Efficacy of chlorhexidine gluconate during surgery for hydatid cyst</article-title><source>World J. Surg.</source><volume>33</volume><year>2009</year><fpage>1274</fpage><lpage>1280</lpage><pub-id pub-id-type="pmid">19288039</pub-id></element-citation></ref><ref id="b1045"><element-citation publication-type="journal" id="h1045"><person-group person-group-type="author"><name><surname>Tritten</surname><given-names>L.</given-names></name><name><surname>Silbereisen</surname><given-names>A.</given-names></name><name><surname>Keiser</surname><given-names>J.</given-names></name></person-group><article-title>Nitazoxanide: <italic>In vitro</italic> and <italic>in vivo</italic> drug effects against <italic>Trichuris muris</italic> and <italic>Ancylostoma ceylanicum</italic>, alone or in combination</article-title><source>Int. J. Parasitol. Drugs Drug Resist.</source><volume>2</volume><year>2012</year><fpage>98</fpage><lpage>105</lpage><pub-id pub-id-type="pmid">24533270</pub-id></element-citation></ref><ref id="b1050"><element-citation publication-type="journal" id="h1050"><person-group person-group-type="author"><name><surname>Tschen</surname><given-names>E.H.</given-names></name><name><surname>Tschen</surname><given-names>E.A.</given-names></name><name><surname>Smith</surname><given-names>E.B.</given-names></name></person-group><article-title>Cutaneous cysticercosis treated with metrifonate</article-title><source>Arch. Dermatol.</source><volume>117</volume><year>1981</year><fpage>507</fpage><lpage>509</lpage><pub-id pub-id-type="pmid">7259247</pub-id></element-citation></ref><ref id="b1055"><element-citation publication-type="journal" id="h1055"><person-group person-group-type="author"><name><surname>Tu</surname><given-names>Y.</given-names></name></person-group><article-title>The discovery of artemisinin (qinghaosu) and gifts from Chinese medicine</article-title><source>Nat. Med.</source><volume>17</volume><year>2011</year><fpage>1217</fpage><lpage>1220</lpage><pub-id pub-id-type="pmid">21989013</pub-id></element-citation></ref><ref id="b1060"><element-citation publication-type="journal" id="h1060"><person-group person-group-type="author"><name><surname>Turner</surname><given-names>J.D.</given-names></name><name><surname>Mand</surname><given-names>S.</given-names></name><name><surname>Debrah</surname><given-names>A.Y.</given-names></name><name><surname>Muehlfeld</surname><given-names>J.</given-names></name><name><surname>Pfarr</surname><given-names>K.</given-names></name><name><surname>McGarry</surname><given-names>H.F.</given-names></name><name><surname>Adjei</surname><given-names>O.</given-names></name><name><surname>Taylor</surname><given-names>M.J.</given-names></name><name><surname>Hoerauf</surname><given-names>A.</given-names></name></person-group><article-title>A randomized, double-blind clinical trial of a 3-week course of doxycycline plus albendazole and ivermectin for the treatment of <italic>Wuchereria bancrofti</italic> infection</article-title><source>Clin. Infect. Dis.</source><volume>42</volume><year>2006</year><fpage>1081</fpage><lpage>1089</lpage><pub-id pub-id-type="pmid">16575724</pub-id></element-citation></ref><ref id="b1065"><element-citation publication-type="journal" id="h1065"><person-group person-group-type="author"><name><surname>Turner</surname><given-names>J.D.</given-names></name><name><surname>Tendongfor</surname><given-names>N.</given-names></name><name><surname>Esum</surname><given-names>M.</given-names></name><name><surname>Johnston</surname><given-names>K.L.</given-names></name><name><surname>Langley</surname><given-names>R.S.</given-names></name><name><surname>Ford</surname><given-names>L.</given-names></name><name><surname>Faragher</surname><given-names>B.</given-names></name><name><surname>Specht</surname><given-names>S.</given-names></name><name><surname>Mand</surname><given-names>S.</given-names></name><name><surname>Hoerauf</surname><given-names>A.</given-names></name><name><surname>Enyong</surname><given-names>P.</given-names></name><name><surname>Wanji</surname><given-names>S.</given-names></name><name><surname>Taylor</surname><given-names>M.J.</given-names></name></person-group><article-title>Macrofilaricidal activity after doxycycline only treatment of <italic>Onchocerca volvulus</italic> in an area of <italic>Loa loa</italic> co-endemicity: a randomized controlled trial</article-title><source>World J. Surg.</source><volume>4</volume><year>2010</year><fpage>e660</fpage></element-citation></ref><ref id="b1070"><element-citation publication-type="journal" id="h1070"><person-group person-group-type="author"><name><surname>Utzinger</surname><given-names>J.</given-names></name><name><surname>N’Goran</surname><given-names>E.K.</given-names></name><name><surname>N’Dri</surname><given-names>A.</given-names></name><name><surname>Lengeler</surname><given-names>C.</given-names></name><name><surname>Xiao</surname><given-names>S.</given-names></name><name><surname>Tanner</surname><given-names>M.</given-names></name></person-group><article-title>Oral artemether for prevention of <italic>Schistosoma mansoni</italic> infection: randomised controlled trial</article-title><source>Lancet</source><volume>355</volume><year>2000</year><fpage>1320</fpage><lpage>1325</lpage><pub-id pub-id-type="pmid">10776745</pub-id></element-citation></ref><ref id="b1075"><element-citation publication-type="journal" id="h1075"><person-group person-group-type="author"><name><surname>Utzinger</surname><given-names>J.</given-names></name><name><surname>Keiser</surname><given-names>J.</given-names></name></person-group><article-title>Schistosomiasis and soil-transmitted helminthiasis: common drugs for treatment and control</article-title><source>Expert Opin. Pharmacother.</source><volume>5</volume><year>2004</year><fpage>263</fpage><lpage>285</lpage><pub-id pub-id-type="pmid">14996624</pub-id></element-citation></ref><ref id="b1080"><element-citation publication-type="journal" id="h1080"><person-group person-group-type="author"><name><surname>Utzinger</surname><given-names>J.</given-names></name><name><surname>Xiao</surname><given-names>S.H.</given-names></name><name><surname>Tanner</surname><given-names>M.</given-names></name><name><surname>Keiser</surname><given-names>J.</given-names></name></person-group><article-title>Artemisinins for schistosomiasis and beyond</article-title><source>Curr. Opin. Investig. Drugs</source><volume>8</volume><year>2007</year><fpage>105</fpage><lpage>116</lpage></element-citation></ref><ref id="b1085"><element-citation publication-type="journal" id="h1085"><person-group person-group-type="author"><name><surname>Utzinger</surname><given-names>J.</given-names></name><name><surname>Tanner</surname><given-names>M.</given-names></name><name><surname>Keiser</surname><given-names>J.</given-names></name></person-group><article-title>ACTs for schistosomiasis: do they act?</article-title><source>Lancet Infect. Dis.</source><volume>10</volume><year>2010</year><fpage>579</fpage><lpage>581</lpage><pub-id pub-id-type="pmid">20705514</pub-id></element-citation></ref><ref id="b1090"><element-citation publication-type="journal" id="h1090"><person-group person-group-type="author"><name><surname>van Blitterswijk</surname><given-names>W.J.</given-names></name><name><surname>Verheij</surname><given-names>M.</given-names></name></person-group><article-title>Anticancer mechanisms and clinical application of alkylphospholipids</article-title><source>Biochim. Biophys. Acta</source><volume>1831</volume><year>2013</year><fpage>663</fpage><lpage>674</lpage><pub-id pub-id-type="pmid">23137567</pub-id></element-citation></ref><ref id="b1095"><element-citation publication-type="journal" id="h1095"><person-group person-group-type="author"><name><surname>Van Kerckhoven</surname><given-names>I.</given-names></name><name><surname>Kumar</surname><given-names>V.</given-names></name></person-group><article-title>Macrofilaricidal activity of oral flubendazole on <italic>Brugia pahangi</italic></article-title><source>Trans. R. Soc. Trop. Med. Hyg.</source><volume>82</volume><year>1988</year><fpage>890</fpage><lpage>891</lpage><pub-id pub-id-type="pmid">3256991</pub-id></element-citation></ref><ref id="b1100"><element-citation publication-type="journal" id="h1100"><person-group person-group-type="author"><name><surname>Vargas-Villavicencio</surname><given-names>J.A.</given-names></name><name><surname>Larralde</surname><given-names>C.</given-names></name><name><surname>De Leon-Nava</surname><given-names>M.A.</given-names></name><name><surname>Escobedo</surname><given-names>G.</given-names></name><name><surname>Morales-Montor</surname><given-names>J.</given-names></name></person-group><article-title>Tamoxifen treatment induces protection in murine cysticercosis</article-title><source>J. Parasitol.</source><volume>93</volume><year>2007</year><fpage>1512</fpage><lpage>1517</lpage><pub-id pub-id-type="pmid">18314701</pub-id></element-citation></ref><ref id="b1105"><element-citation publication-type="journal" id="h1105"><person-group person-group-type="author"><name><surname>Vermund</surname><given-names>S.H.</given-names></name><name><surname>MacLeod</surname><given-names>S.</given-names></name><name><surname>Goldstein</surname><given-names>R.G.</given-names></name></person-group><article-title>Taeniasis unresponsive to a single dose of niclosamide: case report of persistent infection with <italic>Taenia saginata</italic> and a review of therapy</article-title><source>Rev. Infect. Dis.</source><volume>8</volume><year>1986</year><fpage>423</fpage><lpage>426</lpage><pub-id pub-id-type="pmid">3726395</pub-id></element-citation></ref><ref id="b1110"><element-citation publication-type="journal" id="h1110"><person-group person-group-type="author"><name><surname>von Samson-Himmelstjerna</surname><given-names>G.</given-names></name><name><surname>Harder</surname><given-names>A.</given-names></name><name><surname>Sangster</surname><given-names>N.C.</given-names></name><name><surname>Coles</surname><given-names>G.C.</given-names></name></person-group><article-title>Efficacy of two cyclooctadepsipeptides, PF1022A and emodepside, against anthelmintic-resistant nematodes in sheep and cattle</article-title><source>Parasitology</source><volume>130</volume><year>2005</year><fpage>343</fpage><lpage>347</lpage><pub-id pub-id-type="pmid">15796017</pub-id></element-citation></ref><ref id="b1115"><element-citation publication-type="journal" id="h1115"><person-group person-group-type="author"><name><surname>Walker</surname><given-names>M.</given-names></name><name><surname>Rossignol</surname><given-names>J.F.</given-names></name><name><surname>Torgerson</surname><given-names>P.</given-names></name><name><surname>Hemphill</surname><given-names>A.</given-names></name></person-group><article-title><italic>In vitro</italic> effects of nitazoxanide on <italic>Echinococcus granulosus</italic> protoscoleces and metacestodes</article-title><source>J. Antimicrob. Chemother.</source><volume>54</volume><year>2004</year><fpage>609</fpage><lpage>616</lpage><pub-id pub-id-type="pmid">15282238</pub-id></element-citation></ref><ref id="b1275"><element-citation publication-type="journal" id="h1265"><person-group person-group-type="author"><name><surname>Wang</surname><given-names>X.</given-names></name><name><surname>Zhao</surname><given-names>Q.</given-names></name><name><surname>Vargas</surname><given-names>M.</given-names></name><name><surname>Dong</surname><given-names>Y.</given-names></name><name><surname>Sriraghavan</surname><given-names>K.</given-names></name><name><surname>Keiser</surname><given-names>J.</given-names></name><name><surname>Vennerstrom</surname><given-names>J.L.</given-names></name></person-group><article-title>The activity of dispiro peroxides against <italic>Fasciola hepatica</italic></article-title><source>Bioorg. Med. Chem. Lett.</source><volume>21</volume><year>2011</year><fpage>5320</fpage><lpage>5323</lpage><pub-id pub-id-type="pmid">21802291</pub-id></element-citation></ref><ref id="b1280"><element-citation publication-type="journal" id="h1270"><person-group person-group-type="author"><name><surname>Wanji</surname><given-names>S.</given-names></name><name><surname>Tendongfor</surname><given-names>N.</given-names></name><name><surname>Nji</surname><given-names>T.</given-names></name><name><surname>Esum</surname><given-names>M.</given-names></name><name><surname>Che</surname><given-names>J.N.</given-names></name><name><surname>Nkwescheu</surname><given-names>A.</given-names></name><name><surname>Alassa</surname><given-names>F.</given-names></name><name><surname>Kamnang</surname><given-names>G.</given-names></name><name><surname>Enyong</surname><given-names>P.A.</given-names></name><name><surname>Taylor</surname><given-names>M.J.</given-names></name><name><surname>Hoerauf</surname><given-names>A.</given-names></name><name><surname>Taylor</surname><given-names>D.W.</given-names></name></person-group><article-title>Community-directed delivery of doxycycline for the treatment of onchocerciasis in areas of co-endemicity with loiasis in Cameroon</article-title><source>Parasit. Vectors</source><volume>2</volume><year>2009</year><fpage>39</fpage><pub-id pub-id-type="pmid">19712455</pub-id></element-citation></ref><ref id="b1125"><element-citation publication-type="journal" id="h1125"><person-group person-group-type="author"><name><surname>Wells</surname><given-names>T.N.</given-names></name></person-group><article-title>Discovering and developing new medicines for malaria control and elimination</article-title><source>Infect. Disord. Drug Targets</source><volume>13</volume><year>2013</year><fpage>292</fpage><lpage>302</lpage><pub-id pub-id-type="pmid">24304355</pub-id></element-citation></ref><ref id="b0065"><element-citation publication-type="journal" id="h0065"><person-group person-group-type="author"><name><surname>WHO</surname></name></person-group><article-title>Guidelines for treatment of cystic and alveolar echinococcosis in humans. WHO Informal Working Group on Echinococcosis</article-title><source>Bull. World Health Organ.</source><volume>74</volume><year>1996</year><fpage>231</fpage><lpage>242</lpage><pub-id pub-id-type="pmid">8789923</pub-id></element-citation></ref><ref id="b1130"><element-citation publication-type="book" id="h1130"><person-group person-group-type="author"><name><surname>WHO</surname></name></person-group><chapter-title>Preventive chemotherapy in human helminthiasis: coordinated use of anthelminthic drugs in control interventions: a manual for health professionals and programme managers</chapter-title><year>2006</year><publisher-name>World Health Organization</publisher-name><publisher-loc>Geneva</publisher-loc></element-citation></ref><ref id="b1135"><mixed-citation publication-type="other" id="h1135">WHO, 2011. Accelerating work to overcome the global impact of neglected tropical diseases: a roadmap for implementation WHO, Geneva, pp. 1–42.</mixed-citation></ref><ref id="b1140"><element-citation publication-type="book" id="h1140"><person-group person-group-type="author"><name><surname>WHO</surname></name></person-group><chapter-title>WHO model list on essential medicines</chapter-title><year>2013</year><publisher-name>World Health Organization</publisher-name><publisher-loc>Geneva</publisher-loc></element-citation></ref><ref id="b1145"><mixed-citation publication-type="other" id="h1145">WHO/FAO/OIE, 2005. WHO/FAO/OIE Guidelines for the surveillance, prevention and control of taeniosis/cysticercosis, Paris World Organisation for Animal Health.</mixed-citation></ref><ref id="b1150"><element-citation publication-type="journal" id="h1150"><person-group person-group-type="author"><name><surname>Wimmersberger</surname><given-names>D.</given-names></name><name><surname>Tritten</surname><given-names>L.</given-names></name><name><surname>Keiser</surname><given-names>J.</given-names></name></person-group><article-title>Development of an <italic>in vitro</italic> drug sensitivity assay for <italic>Trichuris muris</italic> first-stage larvae</article-title><source>Parasit. Vectors</source><volume>6</volume><year>2013</year><fpage>42</fpage><pub-id pub-id-type="pmid">23433224</pub-id></element-citation></ref><ref id="b1155"><element-citation publication-type="journal" id="h1155"><person-group person-group-type="author"><name><surname>Xiao</surname><given-names>S.H.</given-names></name><name><surname>Keiser</surname><given-names>J.</given-names></name><name><surname>Chollet</surname><given-names>J.</given-names></name><name><surname>Utzinger</surname><given-names>J.</given-names></name><name><surname>Dong</surname><given-names>Y.</given-names></name><name><surname>Vennerstrom</surname><given-names>J.L.</given-names></name><name><surname>Tanner</surname><given-names>M.</given-names></name></person-group><article-title>The <italic>in vitro</italic> and <italic>in vivo</italic> activities of synthetic trioxolanes on major human schistosome species</article-title><source>Antimicrob. Agents Chemother.</source><volume>51</volume><year>2007</year><fpage>1440</fpage><lpage>1445</lpage><pub-id pub-id-type="pmid">17283188</pub-id></element-citation></ref><ref id="b1160"><element-citation publication-type="journal" id="h1160"><person-group person-group-type="author"><name><surname>Xiao</surname><given-names>S.H.</given-names></name><name><surname>Xue</surname><given-names>J.</given-names></name><name><surname>Xu</surname><given-names>L.L.</given-names></name><name><surname>Zheng</surname><given-names>Q.</given-names></name><name><surname>Qiang</surname><given-names>H.Q.</given-names></name><name><surname>Zhang</surname><given-names>Y.N.</given-names></name></person-group><article-title>The <italic>in vitro</italic> and <italic>in vivo</italic> effect of tribendimidine and its metabolites against <italic>Clonorchis sinensis</italic></article-title><source>Parasitol. Res.</source><volume>105</volume><year>2009</year><fpage>1497</fpage><lpage>1507</lpage><pub-id pub-id-type="pmid">19655171</pub-id></element-citation></ref><ref id="b1165"><element-citation publication-type="journal" id="h1165"><person-group person-group-type="author"><name><surname>Xiao</surname><given-names>S.H.</given-names></name><name><surname>Xue</surname><given-names>J.</given-names></name><name><surname>Li-li</surname><given-names>X.</given-names></name><name><surname>Zhang</surname><given-names>Y.N.</given-names></name><name><surname>Qiang</surname><given-names>H.Q.</given-names></name></person-group><article-title>Effectiveness of mefloquine against <italic>Clonorchis sinensis</italic> in rats and <italic>Paragonimus westerman</italic>i in dogs</article-title><source>Parasitol. Res.</source><volume>107</volume><year>2010</year><fpage>1391</fpage><lpage>1397</lpage><pub-id pub-id-type="pmid">20680332</pub-id></element-citation></ref><ref id="b1170"><element-citation publication-type="journal" id="h1170"><person-group person-group-type="author"><name><surname>Xiao</surname><given-names>S.H.</given-names></name><name><surname>Mei</surname><given-names>J.Y.</given-names></name><name><surname>Jiao</surname><given-names>P.Y.</given-names></name></person-group><article-title><italic>Schistosoma japonicum</italic>-infected hamsters (<italic>Mesocricetus auratus</italic>) used as a model in experimental chemotherapy with praziquantel, artemether, and OZ compounds</article-title><source>Parasitol. Res.</source><volume>108</volume><year>2011</year><fpage>431</fpage><lpage>437</lpage><pub-id pub-id-type="pmid">20922422</pub-id></element-citation></ref><ref id="b1175"><element-citation publication-type="journal" id="h1175"><person-group person-group-type="author"><name><surname>Xiao</surname><given-names>S.H.</given-names></name><name><surname>Xue</surname><given-names>J.</given-names></name><name><surname>Mei</surname><given-names>J.Y.</given-names></name><name><surname>Jiao</surname><given-names>P.Y.</given-names></name></person-group><article-title>Effectiveness of synthetic trioxolane OZ78 against <italic>Schistosoma japonicum</italic> in mice and rabbits</article-title><source>Parasitol. Res.</source><volume>110</volume><year>2012</year><fpage>2307</fpage><lpage>2314</lpage><pub-id pub-id-type="pmid">22200956</pub-id></element-citation></ref><ref id="b1180"><element-citation publication-type="journal" id="h1180"><person-group person-group-type="author"><name><surname>Xiao</surname><given-names>S.H.</given-names></name><name><surname>Utzinger</surname><given-names>J.</given-names></name><name><surname>Tanner</surname><given-names>M.</given-names></name><name><surname>Keiser</surname><given-names>J.</given-names></name><name><surname>Xue</surname><given-names>J.</given-names></name></person-group><article-title>Advances with the Chinese anthelminthic drug tribendimidine in clinical trials and laboratory investigations</article-title><source>Acta Trop.</source><volume>126</volume><year>2013</year><fpage>115</fpage><lpage>126</lpage><pub-id pub-id-type="pmid">23352956</pub-id></element-citation></ref><ref id="b1185"><mixed-citation publication-type="other" id="h1185">Xue, J., Wang, X., Dong, Y., Vennerstrom, J.L., Xiao, S.H., 2014. Effect of ozonide OZ418 against <italic>Schistosoma japonicum</italic> harbored in mice. Parasitol. Res. Epub ahead of print.</mixed-citation></ref><ref id="b1190"><element-citation publication-type="journal" id="h1190"><person-group person-group-type="author"><name><surname>Yakoot</surname><given-names>M.</given-names></name></person-group><article-title>A short review of the anthelmintic role of Mirazid</article-title><source>Arq. Gastroenterol.</source><volume>47</volume><year>2010</year><fpage>393</fpage><lpage>394</lpage><pub-id pub-id-type="pmid">21225152</pub-id></element-citation></ref><ref id="b1195"><element-citation publication-type="journal" id="h1195"><person-group person-group-type="author"><name><surname>Yangco</surname><given-names>B.G.</given-names></name><name><surname>Klein</surname><given-names>T.W.</given-names></name><name><surname>Deresinski</surname><given-names>S.C.</given-names></name><name><surname>Vickery</surname><given-names>A.C.</given-names></name><name><surname>Craig</surname><given-names>C.P.</given-names></name></person-group><article-title>Flubendazole and mebendazole in the treatment of trichuriasis and other helminthiases</article-title><source>Clin. Ther.</source><volume>4</volume><year>1981</year><fpage>285</fpage><lpage>290</lpage><pub-id pub-id-type="pmid">7332916</pub-id></element-citation></ref><ref id="b1200"><element-citation publication-type="journal" id="h1200"><person-group person-group-type="author"><name><surname>Yawzinski</surname><given-names>T.A.</given-names></name><name><surname>Tucker</surname><given-names>C.</given-names></name><name><surname>Featherson</surname><given-names>H.</given-names></name><name><surname>Johnson</surname><given-names>Z.</given-names></name><name><surname>Wood-Huels</surname><given-names>N.</given-names></name></person-group><article-title>Endectocidal efficacies of doramectin in naturally parasitized pigs</article-title><source>Vet. Parasitol.</source><volume>70</volume><year>1997</year><fpage>123</fpage><lpage>128</lpage><pub-id pub-id-type="pmid">9195716</pub-id></element-citation></ref><ref id="b1205"><element-citation publication-type="journal" id="h1205"><person-group person-group-type="author"><name><surname>Yuan</surname><given-names>G.</given-names></name><name><surname>Xu</surname><given-names>J.</given-names></name><name><surname>Qu</surname><given-names>T.</given-names></name><name><surname>Wang</surname><given-names>B.</given-names></name><name><surname>Zhang</surname><given-names>R.</given-names></name><name><surname>Wei</surname><given-names>C.</given-names></name><name><surname>Guo</surname><given-names>R.</given-names></name></person-group><article-title>Metabolism and disposition of tribendimidine and its metabolites in healthy Chinese volunteers</article-title><source>Drugs R D</source><volume>10</volume><year>2010</year><fpage>83</fpage><lpage>90</lpage><pub-id pub-id-type="pmid">20698716</pub-id></element-citation></ref><ref id="b1210"><mixed-citation publication-type="other" id="h1210">Zaha, O., Hirata, T., Kinjo, F., Saito, A., 2000. Strongyloidiasis–progress in diagnosis and treatment. Internal medicine (Tokyo, Japan) 39, 695–700.</mixed-citation></ref><ref id="b1215"><element-citation publication-type="journal" id="h1215"><person-group person-group-type="author"><name><surname>Zahner</surname><given-names>H.</given-names></name><name><surname>Taubert</surname><given-names>A.</given-names></name><name><surname>Harder</surname><given-names>A.</given-names></name><name><surname>von Samson-Himmelstjerna</surname><given-names>G.</given-names></name></person-group><article-title>Filaricidal efficacy of anthelmintically active cyclodepsipeptides</article-title><source>Int. J. Parasitol.</source><volume>31</volume><year>2001</year><fpage>1515</fpage><lpage>1522</lpage><pub-id pub-id-type="pmid">11595239</pub-id></element-citation></ref><ref id="b1285"><element-citation publication-type="journal" id="h1275"><person-group person-group-type="author"><name><surname>Zhao</surname><given-names>Q.</given-names></name><name><surname>Vargas</surname><given-names>M.</given-names></name><name><surname>Dong</surname><given-names>Y.</given-names></name><name><surname>Zhou</surname><given-names>L.</given-names></name><name><surname>Wang</surname><given-names>X.</given-names></name><name><surname>Sriraghavan</surname><given-names>K.</given-names></name><name><surname>Keiser</surname><given-names>J.</given-names></name><name><surname>Vennerstrom</surname><given-names>J.L.</given-names></name></person-group><article-title>Structure-activity relationship of an ozonide carboxylic acid (OZ78) against <italic>Fasciola hepatica</italic></article-title><source>J. Med. Chem.</source><volume>53</volume><year>2010</year><fpage>4223</fpage><lpage>4233</lpage><pub-id pub-id-type="pmid">20423101</pub-id></element-citation></ref><ref id="b1290"><element-citation publication-type="journal" id="h1280"><person-group person-group-type="author"><name><surname>Zumaquero-Rios</surname><given-names>J.L.</given-names></name><name><surname>Sarracent-Perez</surname><given-names>J.</given-names></name><name><surname>Rojas-Garcia</surname><given-names>R.</given-names></name><name><surname>Rojas-Rivero</surname><given-names>L.</given-names></name><name><surname>Martinez-Tovilla</surname><given-names>Y.</given-names></name><name><surname>Valero</surname><given-names>M.A.</given-names></name><name><surname>Mas-Coma</surname><given-names>S.</given-names></name></person-group><article-title>Fascioliasis and intestinal parasitoses affecting schoolchildren in Atlixco, Puebla State, Mexico: epidemiology and treatment with nitazoxanide</article-title><source>PLoS Negl. Trop. Dis.</source><volume>7</volume><year>2013</year><fpage>e2553</fpage><pub-id pub-id-type="pmid">24278492</pub-id></element-citation></ref><ref id="b1295"><element-citation publication-type="journal" id="h1285"><person-group person-group-type="author"><name><surname>Zumla</surname><given-names>A.</given-names></name><name><surname>Keiser</surname><given-names>J.</given-names></name></person-group><article-title>Preface: tropical diseases</article-title><source>Infect. Dis. Clin. North Am.</source><volume>26</volume><year>2012</year><fpage>xv</fpage><lpage>xvii</lpage><pub-id pub-id-type="pmid">22632653</pub-id></element-citation></ref></ref-list><ack id="ak010"><title>Acknowledgments</title><p>This work was supported by the <funding-source id="gp005">European Research Council</funding-source> (ERC-2013-CoG614739-A_HERO to G.P and J.K.), the Medicor Foundation (B.S) and the University of Basel Forschungsfonds (U.D.). The authors state that they present no conflict of interest in writing this review.</p></ack></back><floats-group><fig id="f0005"><label>Figure 1</label><caption><p>Sources of compounds for anthelmintic repurposing. A summary of the flelds from which the repurposed drugs discussed in this review are sourced. Only successful drugs and drug candidates were included. “Extended applications” refers to drugs that were already anthelmintics but whose activity was discovered to extend to a broader range of helminth species.</p></caption><graphic xlink:href="gr1"></graphic></fig><table-wrap id="t0005" position="float"><label>Table 1</label><caption><p>Trematocidal <italic>in vivo</italic> drug candidates.</p></caption><table frame="hsides" rules="groups"><thead><tr><th></th><th></th><th></th><th colspan="2">Adult infection<hr></hr></th><th colspan="2">Juvenile infection<hr></hr></th><th></th></tr><tr><th>Parasite</th><th>Drug</th><th>Host animal</th><th>Dose (mg/kg)</th><th>WBR (%)</th><th>Dose (mg/kg)</th><th>WBR (%)</th><th>References</th></tr></thead><tbody><tr><td rowspan="18"><italic>Schistosoma mansoni</italic></td><td>Dihydroartemisinin</td><td>Mouse</td><td>3 × 200–400</td><td>60–70</td><td>3 × 200–400</td><td>89–90</td><td><xref rid="b0695" ref-type="bibr">Li et al. (2012)</xref></td></tr><tr><td rowspan="2">OZ78</td><td>Mouse</td><td>400</td><td>52</td><td>200</td><td>95</td><td><xref rid="b1155" ref-type="bibr">Xiao et al. (2007)</xref></td></tr><tr><td>Hamster</td><td>200</td><td>85</td><td>100</td><td>83</td><td><xref rid="b1155" ref-type="bibr">Xiao et al. (2007)</xref></td></tr><tr><td rowspan="2">OZ288</td><td>Mouse</td><td>400</td><td>0</td><td>200</td><td>82</td><td><xref rid="b1155" ref-type="bibr">Xiao et al. (2007)</xref></td></tr><tr><td>Hamster</td><td>200</td><td>72</td><td>100</td><td>84</td><td><xref rid="b1155" ref-type="bibr">Xiao et al. (2007)</xref></td></tr><tr><td>OZ418</td><td>Mouse</td><td>400</td><td>96</td><td>200</td><td>100</td><td><xref rid="b0610" ref-type="bibr">Keiser et al. (2012a)</xref></td></tr><tr><td>Tribendimidine</td><td>Mouse</td><td>400</td><td>0</td><td>n.d.</td><td>n.d.</td><td><xref rid="b0555" ref-type="bibr">Keiser et al. (2007b)</xref></td></tr><tr><td>Imatinib</td><td>Mouse</td><td>3 × 1000</td><td>0</td><td>n.d.</td><td>n.d.</td><td><xref rid="b0485" ref-type="bibr">Katz et al. (2013)</xref></td></tr><tr><td>Miltefosine</td><td>Mouse</td><td>5 × 20</td><td>95</td><td>5 × 20</td><td>76</td><td><xref rid="b0290" ref-type="bibr">Eissa et al. (2011a)</xref></td></tr><tr><td>Nilutamide</td><td>Mouse</td><td>400</td><td>85</td><td>50–400</td><td>5–36</td><td><xref rid="b0595" ref-type="bibr">Keiser et al. (2010d)</xref></td></tr><tr><td>BTP-iso</td><td>Mouse</td><td>300</td><td>55</td><td>n.d.</td><td>n.d.</td><td><xref rid="b0300" ref-type="bibr">El Bialy et al. (2013)</xref></td></tr><tr><td>Clorsulon</td><td>Mouse</td><td>1–3 × 5</td><td>88–98</td><td>n.d.</td><td>n.d.</td><td><xref rid="b0760" ref-type="bibr">Mossallam et al. (2007)</xref></td></tr><tr><td>Anisomycin</td><td>Mouse</td><td>100</td><td>0</td><td>n.d.</td><td>n.d.</td><td><xref rid="b0015" ref-type="bibr">Abdulla et al. (2009)</xref></td></tr><tr><td>Lasalocid sodium</td><td>Mouse</td><td>100</td><td>41–44</td><td>n.d.</td><td>n.d.</td><td><xref rid="b0015" ref-type="bibr">Abdulla et al. (2009)</xref></td></tr><tr><td>Diffractic acid</td><td>Mouse</td><td>10–40</td><td>0</td><td>n.d.</td><td>n.d.</td><td><xref rid="b0015" ref-type="bibr">Abdulla et al. (2009)</xref></td></tr><tr><td>Gamboic acid</td><td>Mouse</td><td>100</td><td>0</td><td>n.d.</td><td>n.d.</td><td><xref rid="b0015" ref-type="bibr">Abdulla et al. (2009)</xref></td></tr><tr><td>Niclosamide</td><td>Mouse</td><td>100</td><td>0</td><td>n.d.</td><td>n.d.</td><td><xref rid="b0015" ref-type="bibr">Abdulla et al. (2009)</xref></td></tr><tr><td>Rafoxanide</td><td>Mouse</td><td>50</td><td>50–56</td><td>n.d.</td><td>n.d.</td><td><xref rid="b0015" ref-type="bibr">Abdulla et al. (2009)</xref></td></tr><tr><td><italic>Schistosoma haematobium</italic></td><td>OZ418</td><td>Hamster</td><td>400</td><td>86</td><td>n.d.</td><td>n.d.</td><td><xref rid="b0610" ref-type="bibr">Keiser et al. (2012a)</xref></td></tr><tr><td rowspan="4"><italic>Schistosoma japonicum</italic></td><td>Dihydroartemisinin</td><td>Mouse</td><td>300</td><td>61</td><td>300</td><td>65</td><td><xref rid="b0690" ref-type="bibr">Li et al. (2011)</xref></td></tr><tr><td rowspan="3">OZ78</td><td>Hamster</td><td>200</td><td>70–94</td><td>200</td><td>73–81</td><td><xref rid="b1170" ref-type="bibr">Xiao et al. (2011)</xref></td></tr><tr><td>Rabbit</td><td>15</td><td>423</td><td>n.d.</td><td>n.d.</td><td><xref rid="b1175" ref-type="bibr">Xiao et al. (2012)</xref></td></tr><tr><td>Mouse</td><td>200–600</td><td>67–80</td><td>400</td><td>75</td><td><xref rid="b1175" ref-type="bibr">Xiao et al. (2012)</xref></td></tr><tr><td rowspan="4"><italic>Fasciola hepatica</italic></td><td rowspan="2">OZ78</td><td>Rat</td><td>100</td><td>100</td><td>100</td><td>100</td><td><xref rid="b0535" ref-type="bibr">Keiser et al. (2006b)</xref></td></tr><tr><td>Sheep</td><td>50–100</td><td>0</td><td>n.d.</td><td>n.d.</td><td><xref rid="b0585 b0755" ref-type="bibr">Keiser et al. (2010b), Meister et al. (2013)</xref></td></tr><tr><td>MT04</td><td>Sheep</td><td>100</td><td>92</td><td>n.d.</td><td>n.d.</td><td><xref rid="b0755" ref-type="bibr">Meister et al. (2013)</xref></td></tr><tr><td>Tribendimidine</td><td>Rats</td><td>800</td><td>0</td><td>n.d.</td><td>n.d.</td><td><xref rid="b0555" ref-type="bibr">Keiser et al. (2007b)</xref></td></tr><tr><td rowspan="2"><italic>Clonorchis sinensis</italic></td><td>OZ78</td><td>Rat</td><td>300</td><td>99</td><td>300</td><td>79</td><td><xref rid="b0495" ref-type="bibr">Keiser and Utzinger (2007a)</xref></td></tr><tr><td>Tribendimidine</td><td>Rat</td><td>150</td><td>98</td><td>n.d.</td><td>n.d.</td><td><xref rid="b0555" ref-type="bibr">Keiser et al. (2007b)</xref></td></tr><tr><td rowspan="2"><italic>Opisthorchis viverrini</italic></td><td>OZ78</td><td>Hamster</td><td>600</td><td>77</td><td>n.d.</td><td>n.d.</td><td><xref rid="b0495" ref-type="bibr">Keiser and Utzinger (2007a)</xref></td></tr><tr><td>Tribendimidine</td><td>Hamster</td><td>400</td><td>63</td><td>n.d.</td><td>n.d.</td><td><xref rid="b0555" ref-type="bibr">Keiser et al. (2007b)</xref></td></tr></tbody></table><table-wrap-foot><fn><p>WBR indicates worm burden reduction in relation to untreated control animals. n.d. denotes a lack of data.</p></fn></table-wrap-foot></table-wrap><table-wrap id="t0010" position="float"><label>Table 2</label><caption><p>Drugs tested in clinical trials against soil-transmitted helminths (<xref rid="b0680 b0335 b0970 b0885 b0005 b0460 b0960 b0425 b0150 b0910 b0880 b0170 b1195 b0475 b0240 b0030 b0125 b0330" ref-type="bibr">See below-mentioned references for further information</xref>).</p></caption><table frame="hsides" rules="groups"><tbody><tr><td><inline-graphic xlink:href="fx2.gif"></inline-graphic></td></tr></tbody></table></table-wrap><table-wrap id="t0015" position="float"><label>Table 3</label><caption><p>Drugs tested in clinical trials against the major cestodes (<italic>Taenia</italic> and <italic>Echinococcus</italic>).</p></caption><table frame="hsides" rules="groups"><thead><tr><th>Drug</th><th>Parasite</th><th>Number of patients</th><th>Dose</th><th>Outcome</th><th>References</th></tr></thead><tbody><tr><td rowspan="3">Nitazoxanide</td><td><italic>T. saginata</italic><break></break><italic>H. nana</italic></td><td>22<break></break>18</td><td>25 mg/kg<break></break>50 mg/kg</td><td>100% CR<break></break>100% CR</td><td><xref rid="b0895" ref-type="bibr">Rossignol and Maisonneuve (1984)</xref></td></tr><tr><td><italic>T. saginata</italic></td><td>18 children<break></break>34 adults<break></break>(niclosamide and praziquantel-resistant infections)</td><td>20 mg/kg p.o. (children 5–14 years); 500 mg twice daily for 3 days p.o. (> 14 years)</td><td>98% CR</td><td><xref rid="b0675" ref-type="bibr">Lateef et al. (2008)</xref></td></tr><tr><td><italic>Echinococcus</italic> spp. (in combination with albendazole)</td><td>5</td><td>500 mg/12 hours for 3–24 months</td><td>40% improvement (2 patients improved)</td><td><xref rid="b0820" ref-type="bibr">Perez-Molina et al. (2011)</xref></td></tr><tr><td>Mepacrine (quinacrine)</td><td><italic>T. saginata</italic></td><td>86</td><td>1 g p.o. or i.g.</td><td>94%</td><td><xref rid="b0650" ref-type="bibr">Koul et al. (2000)</xref></td></tr><tr><td>Tribendimidine</td><td><italic>Taenia</italic> spp.</td><td>15</td><td>200 mg p.o. single dose (children 5–14 years) 400 mg p.o. single dose (⩾15 years)</td><td>67% CR</td><td><xref rid="b1270" ref-type="bibr">Steinmann et al. (2008)</xref></td></tr><tr><td>Paramomycin</td><td><italic>T. saginata</italic><break></break><italic>H. nana</italic></td><td>145<break></break>49</td><td>1–5 days with 30–50 mg/kg<break></break>30 mg/kg single or double dose</td><td>89–100% CR<break></break>90% CR</td><td><xref rid="b0905" ref-type="bibr">Salem and el-Allaf (1969)</xref></td></tr><tr><td>Chlorhexidine gluconate</td><td><italic>E. granulosis</italic></td><td>30</td><td>0.04% in intracystic injection</td><td>100% death of cystic protoscolices</td><td><xref rid="b1040" ref-type="bibr">Topcu et al. (2009)</xref></td></tr></tbody></table><table-wrap-foot><fn><p>p.o denotes oral treatment, i.g. denotes treatment via a nasogastric tube, CR stands for “cure rate”.</p></fn></table-wrap-foot></table-wrap></floats-group></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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