Management of Chyle Leak after Head and Neck Surgery: Review of Current Treatment Strategies
Identifieur interne : 004A78 ( Pmc/Corpus ); précédent : 004A77; suivant : 004A79Management of Chyle Leak after Head and Neck Surgery: Review of Current Treatment Strategies
Auteurs : Sean W. Delaney ; Haoran Shi ; Alireza Shokrani ; Uttam K. SinhaSource :
- International Journal of Otolaryngology [ 1687-9201 ] ; 2017.
Abstract
Chyle leak formation is an uncommon but serious sequela of head and neck surgery when the thoracic duct is inadvertently injured, particularly with the resection of malignancy low in the neck. The thoracic duct is the primary structure that returns lymph and chyle from the entire left and right lower half of the body. Chyle extravasation can result in delayed wound healing, dehydration, malnutrition, electrolyte disturbances, and immunosuppression. Prompt identification and treatment of a chyle leak are essential for optimal surgical outcome. In this article we will review the current treatment options for iatrogenic cervical chyle leaks.
Url:
DOI: 10.1155/2017/8362874
PubMed: 28203252
PubMed Central: 5288539
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Management of Chyle Leak after Head and Neck Surgery: Review of Current Treatment Strategies</title><author><name sortKey="Delaney, Sean W" sort="Delaney, Sean W" uniqKey="Delaney S" first="Sean W." last="Delaney">Sean W. Delaney</name><affiliation><nlm:aff id="I1">Department of Otolaryngology Head and Neck Surgery, Keck School of Medicine, University of Southern California, 1540 Alcazar St, Suite 204Q, Los Angeles, CA 90033, USA</nlm:aff></affiliation></author><author><name sortKey="Shi, Haoran" sort="Shi, Haoran" uniqKey="Shi H" first="Haoran" last="Shi">Haoran Shi</name><affiliation><nlm:aff id="I2">Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Shokrani, Alireza" sort="Shokrani, Alireza" uniqKey="Shokrani A" first="Alireza" last="Shokrani">Alireza Shokrani</name><affiliation><nlm:aff id="I1">Department of Otolaryngology Head and Neck Surgery, Keck School of Medicine, University of Southern California, 1540 Alcazar St, Suite 204Q, Los Angeles, CA 90033, USA</nlm:aff></affiliation></author><author><name sortKey="Sinha, Uttam K" sort="Sinha, Uttam K" uniqKey="Sinha U" first="Uttam K." last="Sinha">Uttam K. Sinha</name><affiliation><nlm:aff id="I1">Department of Otolaryngology Head and Neck Surgery, Keck School of Medicine, University of Southern California, 1540 Alcazar St, Suite 204Q, Los Angeles, CA 90033, USA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">28203252</idno><idno type="pmc">5288539</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288539</idno><idno type="RBID">PMC:5288539</idno><idno type="doi">10.1155/2017/8362874</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">004A78</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">004A78</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Management of Chyle Leak after Head and Neck Surgery: Review of Current Treatment Strategies</title><author><name sortKey="Delaney, Sean W" sort="Delaney, Sean W" uniqKey="Delaney S" first="Sean W." last="Delaney">Sean W. Delaney</name><affiliation><nlm:aff id="I1">Department of Otolaryngology Head and Neck Surgery, Keck School of Medicine, University of Southern California, 1540 Alcazar St, Suite 204Q, Los Angeles, CA 90033, USA</nlm:aff></affiliation></author><author><name sortKey="Shi, Haoran" sort="Shi, Haoran" uniqKey="Shi H" first="Haoran" last="Shi">Haoran Shi</name><affiliation><nlm:aff id="I2">Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Shokrani, Alireza" sort="Shokrani, Alireza" uniqKey="Shokrani A" first="Alireza" last="Shokrani">Alireza Shokrani</name><affiliation><nlm:aff id="I1">Department of Otolaryngology Head and Neck Surgery, Keck School of Medicine, University of Southern California, 1540 Alcazar St, Suite 204Q, Los Angeles, CA 90033, USA</nlm:aff></affiliation></author><author><name sortKey="Sinha, Uttam K" sort="Sinha, Uttam K" uniqKey="Sinha U" first="Uttam K." last="Sinha">Uttam K. Sinha</name><affiliation><nlm:aff id="I1">Department of Otolaryngology Head and Neck Surgery, Keck School of Medicine, University of Southern California, 1540 Alcazar St, Suite 204Q, Los Angeles, CA 90033, USA</nlm:aff></affiliation></author></analytic><series><title level="j">International Journal of Otolaryngology</title><idno type="ISSN">1687-9201</idno><idno type="eISSN">1687-921X</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Chyle leak formation is an uncommon but serious sequela of head and neck surgery when the thoracic duct is inadvertently injured, particularly with the resection of malignancy low in the neck. The thoracic duct is the primary structure that returns lymph and chyle from the entire left and right lower half of the body. Chyle extravasation can result in delayed wound healing, dehydration, malnutrition, electrolyte disturbances, and immunosuppression. Prompt identification and treatment of a chyle leak are essential for optimal surgical outcome. In this article we will review the current treatment options for iatrogenic cervical chyle leaks. </p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Lee, Y S" uniqKey="Lee Y">Y. S. Lee</name></author><author><name sortKey="Kim, B W" uniqKey="Kim B">B.-W. Kim</name></author><author><name sortKey="Chang, H S" uniqKey="Chang H">H.-S. Chang</name></author><author><name sortKey="Park, C S" uniqKey="Park C">C. S. Park</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lorenz, K" uniqKey="Lorenz K">K. Lorenz</name></author><author><name sortKey="Abuazab, M" uniqKey="Abuazab M">M. Abuazab</name></author><author><name sortKey="Sekulla, C" uniqKey="Sekulla C">C. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Int J Otolaryngol</journal-id><journal-id journal-id-type="iso-abbrev">Int J Otolaryngol</journal-id><journal-id journal-id-type="publisher-id">IJOTO</journal-id><journal-title-group><journal-title>International Journal of Otolaryngology</journal-title></journal-title-group><issn pub-type="ppub">1687-9201</issn><issn pub-type="epub">1687-921X</issn><publisher><publisher-name>Hindawi Publishing Corporation</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">28203252</article-id><article-id pub-id-type="pmc">5288539</article-id><article-id pub-id-type="doi">10.1155/2017/8362874</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title>Management of Chyle Leak after Head and Neck Surgery: Review of Current Treatment Strategies</article-title></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="false">http://orcid.org/0000-0002-8587-7009</contrib-id><name><surname>Delaney</surname><given-names>Sean W.</given-names></name><xref ref-type="aff" rid="I1"><sup>1</sup></xref><xref ref-type="corresp" rid="cor1"><sup>*</sup></xref></contrib><contrib contrib-type="author"><name><surname>Shi</surname><given-names>Haoran</given-names></name><xref ref-type="aff" rid="I2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="false">http://orcid.org/0000-0003-3924-892X</contrib-id><name><surname>Shokrani</surname><given-names>Alireza</given-names></name><xref ref-type="aff" rid="I1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Sinha</surname><given-names>Uttam K.</given-names></name><xref ref-type="aff" rid="I1"><sup>1</sup></xref></contrib></contrib-group><aff id="I1"><sup>1</sup>Department of Otolaryngology Head and Neck Surgery, Keck School of Medicine, University of Southern California, 1540 Alcazar St, Suite 204Q, Los Angeles, CA 90033, USA</aff><aff id="I2"><sup>2</sup>Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles, CA, USA</aff><author-notes><corresp id="cor1">*Sean W. Delaney: <email>seanwdelaney@gmail.com</email></corresp><fn fn-type="other"><p>Academic Editor: Jan Betka</p></fn></author-notes><pub-date pub-type="ppub"><year>2017</year></pub-date><pub-date pub-type="epub"><day>19</day><month>1</month><year>2017</year></pub-date><volume>2017</volume><elocation-id>8362874</elocation-id><history><date date-type="received"><day>13</day><month>9</month><year>2016</year></date><date date-type="accepted"><day>7</day><month>12</month><year>2016</year></date></history><permissions><copyright-statement>Copyright © 2017 Sean W. Delaney et al.</copyright-statement><copyright-year>2017</copyright-year><license xlink:href="https://creativecommons.org/licenses/by/4.0/"><license-p>This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><abstract><p>Chyle leak formation is an uncommon but serious sequela of head and neck surgery when the thoracic duct is inadvertently injured, particularly with the resection of malignancy low in the neck. The thoracic duct is the primary structure that returns lymph and chyle from the entire left and right lower half of the body. Chyle extravasation can result in delayed wound healing, dehydration, malnutrition, electrolyte disturbances, and immunosuppression. Prompt identification and treatment of a chyle leak are essential for optimal surgical outcome. In this article we will review the current treatment options for iatrogenic cervical chyle leaks. </p></abstract></article-meta></front><body><sec id="sec1"><title>1. Introduction</title><p>Chyle leak (CL) from iatrogenic thoracic duct injury is a rare but serious complication of head and neck surgery that occurs in 0.5–1.4% of thyroidectomies [<xref rid="B1" ref-type="bibr">1</xref>–<xref rid="B4" ref-type="bibr">4</xref>] and 2–8% of neck dissections [<xref rid="B5" ref-type="bibr">5</xref>–<xref rid="B8" ref-type="bibr">8</xref>]. The variable anatomy and fragile composition of the thoracic duct render it prone to inadvertent injury. The majority of CL transpires with surgery of the left neck; however, up to 25% of CL occur with right neck surgery [<xref rid="B7" ref-type="bibr">7</xref>, <xref rid="B8" ref-type="bibr">8</xref>]. Although uncommon, CL would surely be encountered in any head and neck surgery practice. Early identification and appropriate management of a CL are imperative for optimal surgical outcome. In this article we aim to review the current treatment strategies for iatrogenic cervical chyle leaks.</p></sec><sec id="sec2"><title>2. Anatomy and Physiology of the Thoracic Duct</title><sec id="sec2.1"><title>2.1. Embryology</title><p>The thoracic duct forms during the 8th week of gestation as two distinct vessels anterior to the aorta, connecting the superior jugular lymph sacs to the inferior cisterna chyli. These vessels develop into the embryonic right and left thoracic ducts and share a number of anastomoses. As the fetus matures, the embryonic thoracic ducts fuse partially to form two distinct lymphatic divisions within the body. The adult thoracic duct is the product of the fusion of the lower 2/3 of the embryonic right duct, the upper 1/3 of the left duct, and their numerous interconnections [<xref rid="B9" ref-type="bibr">9</xref>]. The thoracic duct is the largest lymphatic vessel that drains up to 75% of the body's lymph [<xref rid="B10" ref-type="bibr">10</xref>] from the entire left body and the right side of the body below the diaphragm [<xref rid="B11" ref-type="bibr">11</xref>]. The adult right lymphatic duct receives lymph from the right thorax, arm, and head and neck region (<xref ref-type="fig" rid="fig1">Figure 1</xref>). Variations in the course of the thoracic duct are common and may occur as either a persistence of embryonic structures or failure of normal developmental progression. Although unusual, thoracic ducts draining to right internal jugular vein (IJV) have been described [<xref rid="B12" ref-type="bibr">12</xref>, <xref rid="B13" ref-type="bibr">13</xref>].</p></sec><sec id="sec2.2"><title>2.2. Course of the Thoracic Duct</title><p>The thoracic duct originates from the cisterna chyli, a dilated sac at the level of the 2nd lumbar vertebra that receives lymph from intestinal and lumbar lymphatics [<xref rid="B14" ref-type="bibr">14</xref>] as well as intercostal lymphatics and periaortic lymph nodes [<xref rid="B15" ref-type="bibr">15</xref>]. When the cisterna chyli is congenitally absent, the thoracic duct originates from a haphazard coalescence of lymphatic channels instead [<xref rid="B11" ref-type="bibr">11</xref>].</p><p>Within the abdomen, the thoracic duct ascends along the anterior surface of the lumbar vertebra, between the aorta and azygous vein, to enter the thorax via the aortic hiatus in the posterior mediastinum. Within the thorax, the thoracic duct veers leftward as it continues to ascend, passing posterior to the aortic arch, and enters the root of the left neck lateral to the esophagus. At the root of the neck, the thoracic duct is bordered anteriorly by the left common carotid artery, Vagus nerve, and IJV, medially by the esophagus, laterally by the omohyoid muscle, and posteriorly by the vertebra. From there, the thoracic duct arches superiorly and laterally, anterior to the anterior scalene muscle and phrenic nerve [<xref rid="B14" ref-type="bibr">14</xref>]. The thoracic duct generally courses 3–5 cm superior to the clavicle [<xref rid="B16" ref-type="bibr">16</xref>]; however it has been reportedly found as high as the level of the superior cornu of the thyroid cartilage [<xref rid="B17" ref-type="bibr">17</xref>]. Finally, the thoracic duct turns inferiorly and anteriorly, passing over the subclavian artery to terminate with 1 cm of the confluence of the internal jugular and subclavian veins (<xref ref-type="fig" rid="fig2">Figure 2</xref>) [<xref rid="B16" ref-type="bibr">16</xref>, <xref rid="B18" ref-type="bibr">18</xref>].</p><p>Within this 1 cm region the thoracic duct may terminate into the venous circulation at a number of sites. The most common site is the IJV (46%), followed by the confluence of the IJV and subclavian vein (32%) and the subclavian vein (18%) [<xref rid="B11" ref-type="bibr">11</xref>]. Less commonly, the thoracic duct may terminate in the brachiocephalic vein, external jugular vein, or vertebral vein [<xref rid="B7" ref-type="bibr">7</xref>, <xref rid="B16" ref-type="bibr">16</xref>].</p><p>The thoracic duct generally empties into the venous system as a single duct (76%) [<xref rid="B11" ref-type="bibr">11</xref>], though, bifid and trifid configurations have been described [<xref rid="B7" ref-type="bibr">7</xref>]. Near its termination, the thoracic duct receives additional lymphatics from subsidiary lymphatic trunks of the left neck (jugular, subclavian, and bronchomediastinal trunks) [<xref rid="B16" ref-type="bibr">16</xref>].</p><p>The typical length of the adult thoracic duct is 36–45 cm with an average diameter of 5 mm [<xref rid="B19" ref-type="bibr">38</xref>]. The diameter of the thoracic duct decreases from the abdomen to the thorax and then increases again in the cervical region, reaching up to 1 cm in diameter as it empties into the venous system [<xref rid="B11" ref-type="bibr">11</xref>]. Additionally, rises in intra-abdominal or intrathoracic pressure may further distend the thoracic duct through propagation of hydrostatic forces.</p></sec><sec id="sec2.3"><title>2.3. Function of the Thoracic Duct</title><p>The thoracic duct is the primary structure that returns lymph from the left body and the right body below the diaphragm to the venous circulation. This includes chyle derived from intestinal lacteals [<xref rid="B7" ref-type="bibr">7</xref>, <xref rid="B14" ref-type="bibr">14</xref>]. The thoracic duct serves a crucial role in the maintenance of fluid balance and return of lymph and chyle to the systemic circulation [<xref rid="B16" ref-type="bibr">16</xref>].</p><p>Chyle is composed of lymphatic fluid and chylomicrons from the gastrointestinal system. Its lymphatic fluid contains protein, white blood cells, electrolytes, fat-soluble vitamins, trace elements, and glucose absorbed from the interstitial fluid, to be returned to the systemic circulation [<xref rid="B20" ref-type="bibr">39</xref>]. Chylomicrons consist of esterified monoglycerides and fatty acids combined with cholesterol and proteins. These are formed from the breakdown products of long-chain fatty acids by bile salts and absorbed into the lymphatic system through special lymphatic vessels in the villous region of the intestines known as lacteals. Conversely, the smaller short and medium-chain fatty acids are more water soluble and are absorbed via the intestinal mucosa directly into the hepatic portal vein, thus bypassing the lymphatic system [<xref rid="B21" ref-type="bibr">40</xref>].</p><p>Chyle is propagated within the thoracic duct primarily by the muscular action of breathing and further facilitated by the duct's smooth muscles and internal valves, which prevent retrograde flow. Factors that modulate chyle flow include diet, intestinal function, physical activity, respiration rate, and changes in intra-abdominal and intrathoracic pressure [<xref rid="B21" ref-type="bibr">40</xref>].</p></sec></sec><sec id="sec3"><title>3. Pathophysiology of Iatrogenic Head and Neck Chyle Leak</title><sec id="sec3.1"><title>3.1. Iatrogenic Chylous Fistula in Head and Neck Surgery</title><p>Due to its proximity to the IJV and thin vessel wall, the thoracic duct is particularly susceptible to inadvertent injury during dissection low in the neck [<xref rid="B8" ref-type="bibr">8</xref>]. Prior irradiation [<xref rid="B22" ref-type="bibr">34</xref>] and the presence of metastatic lesions at the confluence of the IJV and subclavian vein [<xref rid="B23" ref-type="bibr">41</xref>] make for a more challenging surgical dissection and significantly greater risk of iatrogenic CL.</p></sec><sec id="sec3.2"><title>3.2. Chyle Leak Sequelae</title><p>Prompt diagnosis and intervention aimed at addressing a CL are essential for favorable surgical outcome. The impact of acute large volume CL includes the loss of protein, fat, and fat-soluble vitamins, trace elements, and lymphocytes in quantities that result in hypovolemia, electrolyte imbalances (hyponatremia, hypochloremia, and hypoproteinemia), malnutrition, and immunosuppression [<xref rid="B8" ref-type="bibr">8</xref>, <xref rid="B20" ref-type="bibr">39</xref>, <xref rid="B24" ref-type="bibr">42</xref>, <xref rid="B25" ref-type="bibr">43</xref>].</p><p>Wound healing complications can result from the disruption of the normal biochemical milieu, manifesting as delayed wound healing, infection, or wound breakdown with fistula formation. Within the wound bed, extravasated chyle provokes an intense inflammatory reaction, prompting the release of proinflammatory cytokines and tissue proteases that interfere with the healing process. The pressure of accumulated chyle beneath skin flaps may decrease tissue perfusion, resulting in flap necrosis [<xref rid="B25" ref-type="bibr">43</xref>]. Systemic metabolic and immunologic derangements associated with CL may further compromise healing [<xref rid="B20" ref-type="bibr">39</xref>].</p><p>A cervical CL can spread from the root of the neck into the mediastinum. With sufficient hydrostatic pressure, the collection of chyle may penetrate the pleural, forming a chylothorax, which presents clinically with shortness of breath, tachypnea, and chest pain.</p></sec></sec><sec id="sec4"><title>4. Diagnosis</title><p>Chyle leaks may be identified intraoperatively or postoperatively. Due to the potential significant morbidity associated with a CL, leaks identified at the time of surgery should be repaired immediately.</p><p>In general, the supraclavicular region should be examined carefully at the conclusion of a head and neck procedure, particularly if the case involves dissection low in the neck. If creamy or milky fluid is noted, the thoracic duct should be identified and ligated [<xref rid="B8" ref-type="bibr">8</xref>]. Given the variable course and collapsibility of the thoracic duct and patient fasting in preparation for surgery, identification of the thoracic duct may prove to be difficult. Magnification with surgical loupes or an operative microscope can assist with visualization. Maneuvers that increase intrathoracic or intra-abdominal pressure may facilitate the identification of a CL as well. Trendelenburg positioning and Valsalva maneuver while the anesthesiologist applies positive pressure to raise intrathoracic pressure [<xref rid="B16" ref-type="bibr">16</xref>] or manual abdominal compression [<xref rid="B26" ref-type="bibr">44</xref>] can propagate hydrostatic forces through the course of the thoracic duct to increase chyle flow and distend the distal thoracic duct to improve visibility. The presence of multiple terminations of the thoracic duct means that even though the thoracic duct may be identified and ligated at the time of surgery, unidentified terminal branches can still result in a CL.</p><p>Postoperatively, sudden high increases in drain output, especially following resumption of feedings that contain fat, should raise suspicion of a CL. On examination the neck may exhibit erythema, lymphedema, or a palpable fluid collection in the supraclavicular region. The drain output would have a creamy or milky appearance. A CL can be diagnosed clinically; however, biochemical assay may be helpful for equivocal cases. Drain fluid with triglyceride level greater than 100 mg/dL [<xref rid="B27" ref-type="bibr">45</xref>] or serum triglyceride [<xref rid="B28" ref-type="bibr">46</xref>, <xref rid="B29" ref-type="bibr">47</xref>] or with the presence of chylomicrons [<xref rid="B22" ref-type="bibr">34</xref>] confirms the diagnosis of a CL (<xref ref-type="table" rid="tab1">Table 1</xref>).</p></sec><sec id="sec5"><title>5. Treatment Options for Chyle Leaks</title><sec id="sec5.1"><title>5.1. Intraoperative Chyle Leak</title><p>When a CL is identified during surgery, the thoracic duct may be ligated with surgical clips or oversewn with nonabsorbable suture. Additionally, locoregional flaps may be incorporated for additional coverage of the surgical bed. The clavicular head of the sternocleidomastoid can be dissected free and sutured to the wound bed [<xref rid="B20" ref-type="bibr">39</xref>]. Although the anterior scalene flap has been described, it is infrequently used due to its small size and the risk of brachial plexus injury during flap harvest [<xref rid="B30" ref-type="bibr">48</xref>]. Finally, a rotational pectoralis major flap can provide sufficient tissue bulk and coverage to reliably address a CL [<xref rid="B31" ref-type="bibr">49</xref>]. Additional topical agents can be applied to the wound bed at the time of surgery and will be discussed below.</p></sec><sec id="sec5.2"><title>5.2. Postoperative Chyle Leak</title><p>Following surgery, management of a CL depends on drain output, patient comorbidities, available institutional expertise, and surgeon preference. Chyle leaks may be broadly categorized as low output (<500 mL/day) or high output (>500 mL/day) based on drain output to assist with treatment decision making. In general, low output CL can be treated effectively with conservative management [<xref rid="B32" ref-type="bibr">50</xref>], while high output fistulas will often respond unsatisfactorily to conservative management alone and require surgical intervention. With that said, drain output alone should not dictate treatment choices. Treatment effectiveness can often be gauged by how much drain output changes in response to particular interventions.</p></sec><sec id="sec5.3"><title>5.3. Conservative Measures</title><sec id="sec5.3.1"><title>5.3.1. Activity</title><p>Because chyle flow is propelled by physical activity, patients with suspected CL should be restricted to bed rest. The head of bed should be elevated (30–40°) [<xref rid="B8" ref-type="bibr">8</xref>] and stool softeners provided to reduce intrathoracic and intra-abdominal pressure with bowel movement.</p></sec><sec id="sec5.3.2"><title>5.3.2. Diet</title><p>With potential high volume fluid shift with protein and electrolytes loss, patients with CL need to be monitored for dehydration and malnutrition. Fluid balance and electrolytes should be checked daily and albumin weekly [<xref rid="B8" ref-type="bibr">8</xref>]. Intravenous fluids should be administered to achieve euvolemia and electrolytes replenished as needed.</p><p>Dietary management plays a crucial role in the nonsurgical management of a CL. All patients with suspected CL should be transitioned to a nonfat diet, low-fat diet, or medium-chain fatty acid (MCFA) diet [<xref rid="B33" ref-type="bibr">51</xref>]. In general, a MCFA diet with protein, metabolic mineral mixture, and multivitamin supplementation is preferable to a nonfat diet [<xref rid="B34" ref-type="bibr">52</xref>]. Because short- and medium-chain fatty acids are largely water soluble and absorbed via the portal venous circulation rather than the gastrointestinal lymphatics, this special diet bypasses the gastrointestinal lymphatic system, resulting in decreased chyle flow at the CL site, allowing the thoracic duct injury to heal faster. Despite this, a MCFA diet does not stop chyle production entirely.</p><p>Orlistat, a pancreatic lipase inhibitor, interferes with lipid metabolism in the duodenum and prevents lipid absorption and may be given as an adjunct to decrease chyle production [<xref rid="B35" ref-type="bibr">53</xref>].</p><p>Alternatively, patients can be made NPO if the drain output is low and suspected duration of CL is short. NPO is rarely implemented today, as alternative superior dietary options are available that do not contribute to ongoing hypovolemia and malnutrition.</p><p>Patients with persistent or high output CL will likely require total parental nutrition (TPN), which bypasses the lymphatic system completely [<xref rid="B8" ref-type="bibr">8</xref>, <xref rid="B36" ref-type="bibr">54</xref>]. While more effective than a MCFA diet at reducing chyle production, the use of TPN must be carefully weighed against its need for central venous access, potential complication of increase infection risk, and metabolic disturbances and high cost [<xref rid="B37" ref-type="bibr">55</xref>].</p></sec><sec id="sec5.3.3"><title>5.3.3. Wound Care</title><p>The use of pressure dressings remains controversial. Some recommend its use to expedite closure of a CL [<xref rid="B6" ref-type="bibr">6</xref>, <xref rid="B8" ref-type="bibr">8</xref>, <xref rid="B32" ref-type="bibr">50</xref>], while others are concerned with its potential compromise of skin flap perfusion [<xref rid="B31" ref-type="bibr">49</xref>, <xref rid="B38" ref-type="bibr">56</xref>].</p><p>Suction drainage, placed at the time of surgery, is invaluable in the evacuation of extravasated chyle and monitoring of drain output to assess both severity of the CL and treatment effectiveness. While helpful in evacuating high output CL, however, some advocate for the timely removal of suction drainage once its output has diminished sufficiently, to avoid the possibility that the drain suction may prohibit the complete resolution of a CL [<xref rid="B5" ref-type="bibr">5</xref>].</p><p>Negative wound pressure therapy, or vacuum-assisted closure, with placement of an air-tight seal over the wound and application of negative pressure to the entire wound bed to remove fluid and shrink wound size has had promising results in preliminary reports, but additional studies are needed to test its true effectiveness [<xref rid="B33" ref-type="bibr">51</xref>]. Furthermore, negative wound pressure therapy requires exposure of the wound bed.</p></sec><sec id="sec5.3.4"><title>5.3.4. Somatostatin and Octreotide</title><p>Somatostatin is a neuroendocrine hormone discovered in 1973, with numerous effects on the digestive and lymphatic systems [<xref rid="B39" ref-type="bibr">57</xref>], and has broad applications for use in therapy for acromegaly, intractable diarrhea, hyperinsulinism, severe gastrointestinal bleeding, pancreatitis, metastatic carcinoids, and tumors secreting vasoactive intestinal peptides [<xref rid="B40" ref-type="bibr">58</xref>]. Animal studies in dogs during the early 1980s revealed that intravenous somatostatin significantly reduced thoracic duct lymph flow [<xref rid="B41" ref-type="bibr">59</xref>]. Then, building upon this discovery Ulíbarb and colleagues [<xref rid="B42" ref-type="bibr">20</xref>] were the first to describe the use of somatostatin for the treatment of CL from thoracic duct injury during a supraglottic laryngectomy in 1990.</p><p>Somatostatin decreases chyle production via reduction of gastric, pancreatic, and intestinal secretions [<xref rid="B44" ref-type="bibr">36</xref>, <xref rid="B33" ref-type="bibr">51</xref>, <xref rid="B43" ref-type="bibr">60</xref>]. It constricts smooth muscles in splanchnic and lymphatic vessels to decrease lymph production [<xref rid="B33" ref-type="bibr">51</xref>] and lymph flow [<xref rid="B24" ref-type="bibr">42</xref>], respectively.</p><p>Somatostatin's major drawback is its short half-life, which requires continuous intravenous infusion. This problem was solved with the development of octreotide, somatostatin's long-acting analog, which permitted administration with long-lasting subcutaneous injections [<xref rid="B22" ref-type="bibr">34</xref>]. Octreotide has gained considerable popularity in the management of CL, first in thoracic surgery and more recently with head and neck surgery. Octreotide is a cost-effective therapy for iatrogenic CL that significantly decreases morbidity, length of stay, and need for surgical intervention [<xref rid="B22" ref-type="bibr">34</xref>].</p><p>From 2001 to 2015 seventeen studies investigating the effectiveness of octreotide in the management of cervical CL were published (<xref ref-type="table" rid="tab2">Table 2</xref>). With the exception of two large case series, most publications were case reports. Jain et al. [<xref rid="B45" ref-type="bibr">24</xref>] recounted their experience treating CL in 19 left modified radical neck dissection patients and Swanson et al. [<xref rid="B22" ref-type="bibr">34</xref>] shared their results treating CL in 12 patients undergoing a number of different head and neck procedures. In these studies, total of 49 patients were treated with subcutaneous octreotide for their CL. Surgeries cited included thyroidectomy with or without neck dissection, modified radical and radical neck dissection, and parathyroidectomy. Chyle leaks occurred with both left and right neck dissections. Nearly all of the studies cited use of suction drainage and dietary modifications. Less than one-third of the authors applied pressure dressings.</p><p>To date, there are no consensus guidelines on the optimal octreotide treatment dose and duration in CL management. In our literature review, the decision of what dosage to use was often anecdotal and occasionally increased by some of the authors when perceived ineffective. Octreotide dosage ranged from 100 <italic>μ</italic>g subcutaneous every 8 to 12 hours to 200 <italic>μ</italic>g subcutaneous every 8 hours [<xref rid="B46" ref-type="bibr">35</xref>]. Time from initiation of octreotide therapy to CL cessation ranged from 1 to 15 days, and total octreotide treatment duration varied widely from 3 to 24 days. In general, octreotide was administered an additional 1-2 days after CL cessation to ensure complete resolution. In Jain et al.'s [<xref rid="B45" ref-type="bibr">24</xref>] study, low output leaks (<500 mL/day) stopped after 2–4 days of octreotide and these patients were given a total of 5 days of octreotide; high output leaks (>500 mL/day) resolved after 5 days of octreotide and this cohort was treated for a total of 7 days. Although Swanson et al. [<xref rid="B22" ref-type="bibr">34</xref>] did not stratify their treatment groups by drain output, CL in their series resolved on average 5.5 days after initiation of octreotide therapy, and their patients were treated for approximately 9 days total.</p><p>The most commonly associated side effects of octreotide are nausea, abdominal discomfort, and diarrhea. Rare but serious complications include hypoglycemia and cholecystitis secondary to cholestasis [<xref rid="B47" ref-type="bibr">61</xref>]. In less than 1% of patients, anaphylactic shock, gastrointestinal bleeding, and pulmonary embolism have been described. Octreotide should be prescribed with caution in patients with preexisting cardiovascular and hepatic disease [<xref rid="B22" ref-type="bibr">34</xref>]. Most adverse effects are dose and duration dependent [<xref rid="B48" ref-type="bibr">27</xref>].</p><p>Octreotide has emerged as a powerful adjunct in the conservative management of CL and should be a part of the armamentarium of every head and neck surgeon. However, not every CL will respond completely to octreotide therapy alone. In our literature review, two patients required surgical reexploration for control of their CL, despite a trial of octreotide [<xref rid="B49" ref-type="bibr">23</xref>, <xref rid="B50" ref-type="bibr">25</xref>]. Most authors agreed that if there is no reduction in drain output after 5 days of octreotide therapy then surgical exploration is indicated [<xref rid="B20" ref-type="bibr">39</xref>].</p></sec></sec><sec id="sec5.4"><title>5.4. Topical Agents</title><p>Sclerosing agents such as OK-432 or tetracycline administered at the time of surgery or postoperatively through drainage tubing or percutaneous injection can generate fibrosis to seal a CL [<xref rid="B3" ref-type="bibr">3</xref>, <xref rid="B20" ref-type="bibr">39</xref>]. Should the CL persist, however, the surgical field obliteration by the sclerosing agent makes reoperation considerably more challenging. Furthermore, sclerosing agents should be used with care, as it could potentially injure surrounding structures in the wound bed. Phrenic nerve paralysis after doxycycline sclerotherapy for CL has been reported [<xref rid="B51" ref-type="bibr">62</xref>].</p><p>Cyanoacrylate adhesives, fibrin glue [<xref rid="B52" ref-type="bibr">63</xref>–<xref rid="B54" ref-type="bibr">65</xref>], and polyglactin (Vicryl) mesh [<xref rid="B53" ref-type="bibr">64</xref>] have been placed at the time of surgery, with success, for controlling visible CL.</p></sec><sec id="sec5.5"><title>5.5. Surgical Exploration</title><p>Surgical reexploration should be considered only after conservative measures have either been exhausted or deemed ineffective. Suggested criteria for reexploration range from outputs of >500 mL/day to >1000 mL/day output for 5 days [<xref rid="B1" ref-type="bibr">1</xref>, <xref rid="B8" ref-type="bibr">8</xref>, <xref rid="B56" ref-type="bibr">22</xref>, <xref rid="B55" ref-type="bibr">66</xref>]. Although the recommended criteria for reexploration vary considerably, the general sense is that surgical reexploration should take place when a CL does not respond appropriately to conservative management. Generally speaking, surgical intervention should be decided upon within first 4-5 days of a CL, when prompt response to medical management is absent [<xref rid="B6" ref-type="bibr">6</xref>].</p><p>At the time of reexploration, local inflammation from extravasated chyle can make thoracic duct identification difficult. Trendelenberg positioning and maneuvers that raise intrathoracic and intra-abdominal pressure can facilitate identification of the site of the CL. Having the patient ingest a fatty diet before surgery can stimulate chyle production and aid in CL localization as well.</p><p>As described above, when identified, the leaking thoracic duct can be ligated, covered with a muscle flap, or treated with any number of sclerosing agents, adhesive agents, or mesh. It is imperative that a suction drain is placed at the conclusion of the case.</p></sec><sec id="sec5.6"><title>5.6. Distant Management</title><p>In certain instances, when there is a persistent CL after surgical reexploration or when reexploration may not be ideal because of distorted anatomy or tenuous in the case of a microvascular free flap, the head and neck surgeon may seek the assistance of his interventional radiology or thoracic-foregut colleagues for distant management of a thoracic duct leak.</p><p>Percutaneous transabdominal cannulation of the thoracic duct at the cisterna chyli with lymphography and selective distal embolization with coils or tissue adhesive is a safe and minimally invasive technique for the treatment of CL that do not respond to conservative management, with a reported success rate of 45–70% [<xref rid="B27" ref-type="bibr">45</xref>, <xref rid="B33" ref-type="bibr">51</xref>]. Given the relative low morbidity and reasonable success rate, this may be a viable alternative to surgical exploration, if one's facility has the appropriate equipment and personnel. The major drawback to this method is that it can be time-consuming and often require multiple attempts [<xref rid="B57" ref-type="bibr">67</xref>].</p><p>For patients with failed surgical ligation, thoracoscopic ligation can be an effective salvage procedure that addresses the thoracic duct proximally [<xref rid="B20" ref-type="bibr">39</xref>]. Exposure and ligation of the thoracic duct are performed through a right sided thoracoscopic approach, through which the thoracic duct is ligated at the supradiaphragmatic hiatus between the aorta and azygous vein [<xref rid="B55" ref-type="bibr">66</xref>, <xref rid="B58" ref-type="bibr">68</xref>].</p></sec></sec><sec id="sec6"><title>6. Discussion</title><p>The variable course and fragile composition of the thoracic duct make it vulnerable to iatrogenic injury during head and neck procedures that involve dissection low in the neck. In certain instances, inadvertent injury to the thoracic duct is unavoidable, particularly with the extirpation of malignancy. Fear of iatrogenic CL should not preclude sound oncologic resection. Rather, identification and ligation of a CL during surgery or its timely recognition and treatment in the postoperative period are essential for best surgical outcomes.</p><p>An appreciation of the anatomy, variable course, and possible termination patterns of the thoracic duct will lead to a more comprehensive management of any potential intraoperative CL. Additionally, increases in intrathoracic and intra-abdominal pressure and preoperative feeding of a fatty meal can help with localization of a CL.</p><p>The surgical care team should be vigilant for a CL if the surgery involved dissection in the vicinity of the confluence of the IJV and subclavian vein, on either side of the neck. High drain output, sudden increase of drain output after resumption of enteral feeds, or a creamy appearance of the drain output should all raise suspicion of a CL. A CL can be diagnosed clinically; however, in ambiguous cases, biochemical assay of drain contents may be helpful.</p><p>Chyle leaks can significantly impact wound healing and cause hypovolemia, malnutrition, electrolyte disturbances, and immunosuppression. Therefore, conservative management should be initiated immediately when a CL is diagnosed following surgery. This includes bed rest and head of bed elevation with a MCFA/nonfat diet or TPN. Fluid balance, electrolytes, and protein status should also be monitored closely.</p><p>If a CL does not respond satisfactorily to conservative management alone, surgical control locally or distantly should be considered. There is much debate about the exact criteria for and timing of surgical reexploration. Muscle flaps, sclerosing agents, and adhesives can be applied at the time of surgery as an adjunct to thoracic duct ligation. Suction drainage is essential for evacuation of chyle from the wound bed and to monitor output. For recalcitrant CL or circumstances that preclude reexploration, CL can be addressed distantly with thoracic duct catheterization and embolization or thoracoscopic thoracic duct ligation. The services available at each medical institution may differ and should be taken into account when deciding on the best management plan (<xref ref-type="fig" rid="fig3">Figure 3</xref>).</p></sec><sec id="sec7"><title>7. Conclusion</title><p>Chyle leak formation is an uncommon but serious sequela of head and neck surgery, particularly with the resection of malignancy low in the neck. Chyle extravasation can result in delayed wound healing, dehydration, malnutrition, electrolyte disturbances, and immunosuppression. Prompt identification and treatment of a chyle leak are essential for optimal surgical outcomes.</p></sec></body><back><glossary><title>Abbreviations</title><def-list><def-item><term>CL:</term><def><p>Chyle leak</p></def></def-item><def-item><term>TPN:</term><def><p>Total parental nutrition</p></def></def-item><def-item><term>IJV:</term><def><p>Internal jugular vein</p></def></def-item><def-item><term>MCFA:</term><def><p>Middle chain fatty acid.</p></def></def-item></def-list></glossary><sec sec-type="COI-statement"><title>Competing Interests</title><p>The authors declare that they have no competing interests.</p></sec><ref-list><ref id="B1"><label>1</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lee</surname><given-names>Y. S.</given-names></name><name><surname>Kim</surname><given-names>B.-W.</given-names></name><name><surname>Chang</surname><given-names>H.-S.</given-names></name><name><surname>Park</surname><given-names>C. 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C.</given-names></name><name><surname>Brown</surname><given-names>D. H.</given-names></name><name><surname>Gullane</surname><given-names>P. J.</given-names></name><name><surname>McKneally</surname><given-names>M.</given-names></name></person-group><article-title>Thoracoscopic management of chylous fistulae</article-title><source><italic>American Journal of Otolaryngology—Head and Neck Medicine and Surgery</italic></source><year>1998</year><volume>19</volume><issue>4</issue><fpage>257</fpage><lpage>262</lpage><pub-id pub-id-type="doi">10.1016/s0196-0709(98)90128-4</pub-id><pub-id pub-id-type="other">2-s2.0-0031846151</pub-id></element-citation></ref></ref-list></back><floats-group><fig id="fig1" orientation="portrait" position="float"><label>Figure 1</label><caption><p>Lymphatic division. The right lymphatic duct collects lymph from the right side of the body, above the diaphragm. The thoracic duct receives lymph from the entire left side of the body and the right side of the body below the diaphragm.</p></caption><graphic xlink:href="IJOTO2017-8362874.001"></graphic></fig><fig id="fig2" orientation="portrait" position="float"><label>Figure 2</label><caption><p>Cervical course of the thoracic duct. The thoracic duct enters the neck lateral to the esophagus, ascending superiorly and laterally behind to the carotid and internal jugular vein before turning inferiorly and anteriorly to join the venous circulation at the confluence of the internal jugular vein and subclavian vein.</p></caption><graphic xlink:href="IJOTO2017-8362874.002"></graphic></fig><fig id="fig3" orientation="portrait" position="float"><label>Figure 3</label><caption><p>Proposed treatment algorithm for the postoperative chyle leak.</p></caption><graphic xlink:href="IJOTO2017-8362874.003"></graphic></fig><table-wrap id="tab1" orientation="portrait" position="float"><label>Table 1</label><caption><p>Diagnosing a chyle leak.</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="left" rowspan="1" colspan="1">Clinical</th><th align="left" rowspan="1" colspan="1">Drain output biochemical assay</th></tr></thead><tbody><tr><td align="left" rowspan="1" colspan="1">(i) Sudden increase in drain output, especially immediately following enteral feeding<break></break>(ii) Supraclavicular erythema, lymphedema, or palpable fluid collection<break></break>(iii) Creamy or milky drain output<break></break></td><td align="left" rowspan="1" colspan="1">(i) Triglyceride > 100 mg/dL<break></break>(ii) Triglyceride > serum triglyceride level<break></break>(iii) Presence of chylomicrons</td></tr></tbody></table></table-wrap><table-wrap id="tab2" orientation="portrait" position="float"><label>Table 2</label><caption><p>Literature review of somatostatin and octreotide for treatment of chyle leak.</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="left" rowspan="1" colspan="1">Author</th><th align="center" rowspan="1" colspan="1">Year</th><th align="center" rowspan="1" colspan="1">Patients</th><th align="center" rowspan="1" colspan="1">Surgery</th><th align="center" rowspan="1" colspan="1">Treatment dosage</th><th align="center" rowspan="1" colspan="1">Treatment duration</th><th align="center" rowspan="1" colspan="1">Treatment start to leak cessation</th><th align="center" rowspan="1" colspan="1">Additional measures</th><th align="center" rowspan="1" colspan="1">Comments</th></tr></thead><tbody><tr><td colspan="9" align="center" rowspan="1">Somatostatin</td></tr><tr><td align="center" colspan="9" rowspan="1"><hr></hr></td></tr><tr><td align="left" rowspan="1" colspan="1">Coşkun and Yildirim [<xref rid="B59" ref-type="bibr">19</xref>]</td><td align="center" rowspan="1" colspan="1">2010</td><td align="center" rowspan="1" colspan="1">1</td><td align="center" rowspan="1" colspan="1">Thyroidectomy + L MRND</td><td align="center" rowspan="1" colspan="1">3 mg iv Qday</td><td align="center" rowspan="1" colspan="1">5 days</td><td align="center" rowspan="1" colspan="1">1 day</td><td align="center" rowspan="1" colspan="1">Suction drainage<break></break>Dietary modifications<break></break></td><td align="center" rowspan="1" colspan="1"> </td></tr><tr><td align="center" colspan="9" rowspan="1"><hr></hr></td></tr><tr><td align="left" rowspan="1" colspan="1">Ulíbarb et al. [<xref rid="B42" ref-type="bibr">20</xref>]</td><td align="center" rowspan="1" colspan="1">1990</td><td align="center" rowspan="1" colspan="1">1</td><td align="center" rowspan="1" colspan="1">Supraglottic laryngectomy + L MRND</td><td align="center" rowspan="1" colspan="1">6 mg iv Qday</td><td align="center" rowspan="1" colspan="1">12 days</td><td align="center" rowspan="1" colspan="1">5 days</td><td align="center" rowspan="1" colspan="1">Suction drainage<break></break>Dietary modifications<break></break>Pressure dressing<break></break></td><td align="center" rowspan="1" colspan="1"> </td></tr><tr><td align="center" colspan="9" rowspan="1"><hr></hr></td></tr><tr><td colspan="9" align="center" rowspan="1">Octreotide</td></tr><tr><td align="center" colspan="9" rowspan="1"><hr></hr></td></tr><tr><td align="left" rowspan="1" colspan="1">Ahn et al. [<xref rid="B60" ref-type="bibr">21</xref>]</td><td align="center" rowspan="1" colspan="1">2012</td><td align="center" rowspan="1" colspan="1">2</td><td align="center" rowspan="1" colspan="1">L MRND (1) <break></break>Thyroidectomy + R MRND (1)</td><td align="center" rowspan="1" colspan="1">100 <italic>µ</italic>g sc Q8–12</td><td align="center" rowspan="1" colspan="1">11 days</td><td align="center" rowspan="1" colspan="1">11 days</td><td align="center" rowspan="1" colspan="1">Suction drainage<break></break>Pressure dressing</td><td align="center" rowspan="1" colspan="1"> </td></tr><tr><td align="center" colspan="9" rowspan="1"><hr></hr></td></tr><tr><td align="left" rowspan="1" colspan="1">Al-Sebeih et al. [<xref rid="B56" ref-type="bibr">22</xref>]</td><td align="center" rowspan="1" colspan="1">2001</td><td align="center" rowspan="1" colspan="1">1</td><td align="center" rowspan="1" colspan="1">Total laryngectomy + B MRND</td><td align="center" rowspan="1" colspan="1">100 <italic>µ</italic>g sc Q8</td><td align="center" rowspan="1" colspan="1">Not specified</td><td align="center" rowspan="1" colspan="1">3 days</td><td align="center" rowspan="1" colspan="1">Suction drainage<break></break>Dietary modifications<break></break></td><td align="center" rowspan="1" colspan="1">B chylothoraces requiring chest tubes</td></tr><tr><td align="center" colspan="9" rowspan="1"><hr></hr></td></tr><tr><td align="left" rowspan="1" colspan="1">Harlak et al. [<xref rid="B49" ref-type="bibr">23</xref>]</td><td align="center" rowspan="1" colspan="1">2008</td><td align="center" rowspan="1" colspan="1">1</td><td align="center" rowspan="1" colspan="1">R MRND</td><td align="center" rowspan="1" colspan="1">100 <italic>µ</italic>g sc Q8</td><td align="center" rowspan="1" colspan="1">15 days</td><td align="center" rowspan="1" colspan="1">15 days</td><td align="center" rowspan="1" colspan="1">Suction drainage<break></break>Dietary modifications<break></break>Pressure dressing<break></break>Surgical exploration w/fibrin glue</td><td align="center" rowspan="1" colspan="1">Metastatic breast cancer<break></break>Reexploration for persistent leak</td></tr><tr><td align="center" colspan="9" rowspan="1"><hr></hr></td></tr><tr><td align="left" rowspan="1" colspan="1">Jain et al. [<xref rid="B45" ref-type="bibr">24</xref>]</td><td align="center" rowspan="1" colspan="1">2015</td><td align="center" rowspan="1" colspan="1">19</td><td align="center" rowspan="1" colspan="1">Left neck dissection (19)</td><td align="center" rowspan="1" colspan="1">100 <italic>µ</italic>g sc Q8</td><td align="center" rowspan="1" colspan="1">Low output 5 days<break></break>High output 7 days</td><td align="center" rowspan="1" colspan="1">Low output 2–4 days<break></break>High output 5 days</td><td align="center" rowspan="1" colspan="1">Suction drainage<break></break>Dietary modifications <break></break>Pressure dressing</td><td align="center" rowspan="1" colspan="1">Low output <500 mL/24 hours,<break></break>high output >500 mL/24 hours<break></break></td></tr><tr><td align="center" colspan="9" rowspan="1"><hr></hr></td></tr><tr><td align="left" rowspan="1" colspan="1">Jiménez et al. [<xref rid="B50" ref-type="bibr">25</xref>]</td><td align="center" rowspan="1" colspan="1">2008</td><td align="center" rowspan="1" colspan="1">1</td><td align="center" rowspan="1" colspan="1">Thyroidectomy + B MRND</td><td align="center" rowspan="1" colspan="1">100 <italic>µ</italic>g sc Q8 > somatostatin 6 mg iv Qday</td><td align="center" rowspan="1" colspan="1">11 days</td><td align="center" rowspan="1" colspan="1">N/A</td><td align="center" rowspan="1" colspan="1">Suction drainage<break></break>Dietary modifications<break></break>Surgical Exploration<break></break></td><td align="center" rowspan="1" colspan="1">Right sided chyle leak<break></break>Leak resolved with definitive surgical intervention<break></break>Switched from octreotide to somatostatin</td></tr><tr><td align="center" colspan="9" rowspan="1"><hr></hr></td></tr><tr><td align="left" rowspan="1" colspan="1">El Dabe Mikhail et al. [<xref rid="B61" ref-type="bibr">26</xref>]</td><td align="center" rowspan="1" colspan="1">2009</td><td align="center" rowspan="1" colspan="1">1</td><td align="center" rowspan="1" colspan="1">Thyroidectomy</td><td align="center" rowspan="1" colspan="1">Not specified</td><td align="center" rowspan="1" colspan="1">5 days</td><td align="center" rowspan="1" colspan="1">5 days</td><td align="center" rowspan="1" colspan="1">Dietary modifications<break></break>Pressure dressing<break></break></td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="center" colspan="9" rowspan="1"><hr></hr></td></tr><tr><td align="left" rowspan="1" colspan="1">Nyquist et al. [<xref rid="B48" ref-type="bibr">27</xref>]</td><td align="center" rowspan="1" colspan="1">2003</td><td align="center" rowspan="1" colspan="1">1</td><td align="center" rowspan="1" colspan="1">Thyroidectomy + L MRND</td><td align="center" rowspan="1" colspan="1">100 <italic>µ</italic>g sc Q8</td><td align="center" rowspan="1" colspan="1">8 days</td><td align="center" rowspan="1" colspan="1">1 day</td><td align="center" rowspan="1" colspan="1">Suction drainage<break></break>Dietary modifications<break></break>Pressure dressing<break></break></td><td align="center" rowspan="1" colspan="1"> </td></tr><tr><td align="center" colspan="9" rowspan="1"><hr></hr></td></tr><tr><td align="left" rowspan="1" colspan="1">Ogi et al. [<xref rid="B62" ref-type="bibr">28</xref>]</td><td align="center" rowspan="1" colspan="1">2013</td><td align="center" rowspan="1" colspan="1">1</td><td align="center" rowspan="1" colspan="1">Thyroidectomy + B MRND</td><td align="center" rowspan="1" colspan="1">100 <italic>µ</italic>g sc Q12</td><td align="center" rowspan="1" colspan="1">3 days</td><td align="center" rowspan="1" colspan="1">3 days</td><td align="center" rowspan="1" colspan="1">Suction drainage <break></break>Dietary modifications<break></break></td><td align="center" rowspan="1" colspan="1"> </td></tr><tr><td align="center" colspan="9" rowspan="1"><hr></hr></td></tr><tr><td align="left" rowspan="1" colspan="1">Prabhu and Thomas [<xref rid="B63" ref-type="bibr">29</xref>]</td><td align="center" rowspan="1" colspan="1">2015</td><td align="center" rowspan="1" colspan="1">1</td><td align="center" rowspan="1" colspan="1">L radical neck dissection</td><td align="center" rowspan="1" colspan="1">100 <italic>µ</italic>g sc Q8</td><td align="center" rowspan="1" colspan="1">14 days</td><td align="center" rowspan="1" colspan="1">14 days</td><td align="center" rowspan="1" colspan="1">Suction drainage <break></break>Dietary modifications<break></break>Surgical exploration w/tetracycline</td><td align="center" rowspan="1" colspan="1">L chylothorax<break></break>Side effect: vomiting</td></tr><tr><td align="center" colspan="9" rowspan="1"><hr></hr></td></tr><tr><td align="left" rowspan="1" colspan="1">Rodier et al. [<xref rid="B64" ref-type="bibr">30</xref>]</td><td align="center" rowspan="1" colspan="1">2011</td><td align="center" rowspan="1" colspan="1">1</td><td align="center" rowspan="1" colspan="1">Thyroidectomy + central & L MRND (1)</td><td align="center" rowspan="1" colspan="1">100 <italic>µ</italic>g sc Q8</td><td align="center" rowspan="1" colspan="1">6 days</td><td align="center" rowspan="1" colspan="1">6 days</td><td align="center" rowspan="1" colspan="1">Suction drainage <break></break>Dietary modifications</td><td align="center" rowspan="1" colspan="1"> </td></tr><tr><td align="center" colspan="9" rowspan="1"><hr></hr></td></tr><tr><td align="left" rowspan="1" colspan="1">Srikumar et al. [<xref rid="B65" ref-type="bibr">31</xref>]</td><td align="center" rowspan="1" colspan="1">2006</td><td align="center" rowspan="1" colspan="1">1</td><td align="center" rowspan="1" colspan="1">L radical neck dissection</td><td align="center" rowspan="1" colspan="1">200 <italic>µ</italic>g sc Qday</td><td align="center" rowspan="1" colspan="1">14 days</td><td align="center" rowspan="1" colspan="1">14 days</td><td align="center" rowspan="1" colspan="1">Suction drainage<break></break>Dietary modifications</td><td align="center" rowspan="1" colspan="1">B chylothoraces requiring chest tubes<break></break></td></tr><tr><td align="center" colspan="9" rowspan="1"><hr></hr></td></tr><tr><td align="left" rowspan="1" colspan="1">Suver et al. [<xref rid="B66" ref-type="bibr">32</xref>]</td><td align="center" rowspan="1" colspan="1">2004</td><td align="center" rowspan="1" colspan="1">1</td><td align="center" rowspan="1" colspan="1">B MRND + mediastinal dissection</td><td align="center" rowspan="1" colspan="1">4 <italic>µ</italic>g/kg/hr</td><td align="center" rowspan="1" colspan="1">7</td><td align="center" rowspan="1" colspan="1">7</td><td align="center" rowspan="1" colspan="1">Suction drainage<break></break>Dietary modifications</td><td align="center" rowspan="1" colspan="1">Lymphatic malformation in 10-month-old child</td></tr><tr><td align="center" colspan="9" rowspan="1"><hr></hr></td></tr><tr><td align="left" rowspan="1" colspan="1">Suslu et al. [<xref rid="B67" ref-type="bibr">33</xref>]</td><td align="center" rowspan="1" colspan="1">2014</td><td align="center" rowspan="1" colspan="1">3</td><td align="center" rowspan="1" colspan="1">Thyroidectomy + L MRND (1) Thyroidectomy + B MRND (1)<break></break>Radical neck dissection (1)</td><td align="center" rowspan="1" colspan="1">100 <italic>µ</italic>g sc Q8</td><td align="center" rowspan="1" colspan="1">7.5</td><td align="center" rowspan="1" colspan="1">6.5</td><td align="center" rowspan="1" colspan="1">Suction drainage <break></break>Dietary modifications<break></break>Surgical exploration</td><td align="center" rowspan="1" colspan="1">L chylothorax (1)<break></break>Failed surgical exploration (2)<break></break>Laterality not specified</td></tr><tr><td align="center" colspan="9" rowspan="1"><hr></hr></td></tr><tr><td align="left" rowspan="1" colspan="1">Swanson et al. [<xref rid="B22" ref-type="bibr">34</xref>]</td><td align="center" rowspan="1" colspan="1">2015</td><td align="center" rowspan="1" colspan="1">12</td><td align="center" rowspan="1" colspan="1">L MRND (3) <break></break>R MRND (1) <break></break>Thyroidectomy + B MRND (3) Thyroidectomy (4) <break></break>Parathyroidectomy (1)</td><td align="center" rowspan="1" colspan="1">100 <italic>µ</italic>g sc Q8</td><td align="center" rowspan="1" colspan="1">9.4</td><td align="center" rowspan="1" colspan="1">5.5</td><td align="center" rowspan="1" colspan="1">Suction drainage <break></break>Dietary modifications</td><td align="center" rowspan="1" colspan="1"> </td></tr><tr><td align="center" colspan="9" rowspan="1"><hr></hr></td></tr><tr><td align="left" rowspan="1" colspan="1">Touska et al. [<xref rid="B46" ref-type="bibr">35</xref>]</td><td align="center" rowspan="1" colspan="1">2002</td><td align="center" rowspan="1" colspan="1">1</td><td align="center" rowspan="1" colspan="1">R completion thyroid lobectomy</td><td align="center" rowspan="1" colspan="1">200 <italic>µ</italic>g sc Q8</td><td align="center" rowspan="1" colspan="1">17</td><td align="center" rowspan="1" colspan="1">10</td><td align="center" rowspan="1" colspan="1">Suction drainage <break></break>Dietary modifications</td><td align="center" rowspan="1" colspan="1">No suction drain initially<break></break>Reoperation for suspected abscess<break></break>Discharged with 7-day course of octreotide</td></tr><tr><td align="center" colspan="9" rowspan="1"><hr></hr></td></tr><tr><td align="left" rowspan="1" colspan="1">Valentine et al. [<xref rid="B44" ref-type="bibr">36</xref>]</td><td align="center" rowspan="1" colspan="1">2002</td><td align="center" rowspan="1" colspan="1">1</td><td align="center" rowspan="1" colspan="1">Thyroidectomy + L MRND</td><td align="center" rowspan="1" colspan="1">50–100 <italic>µ</italic>g sc Q8</td><td align="center" rowspan="1" colspan="1">24</td><td align="center" rowspan="1" colspan="1">24</td><td align="center" rowspan="1" colspan="1">Suction drainage <break></break>Dietary modifications<break></break></td><td align="center" rowspan="1" colspan="1">Octreotide dose increased from 50 ug to 100 <italic>µ</italic>g sc Q8 not effective</td></tr><tr><td align="center" colspan="9" rowspan="1"><hr></hr></td></tr><tr><td align="left" rowspan="1" colspan="1">Khurana et al. [<xref rid="B68" ref-type="bibr">37</xref>]</td><td align="center" rowspan="1" colspan="1">2009</td><td align="center" rowspan="1" colspan="1">1</td><td align="center" rowspan="1" colspan="1">Thyroidectomy + B MRND</td><td align="center" rowspan="1" colspan="1">100 <italic>µ</italic>g sc Q8</td><td align="center" rowspan="1" colspan="1">Not specified</td><td align="center" rowspan="1" colspan="1">Not specified</td><td align="center" rowspan="1" colspan="1">Suction drainage<break></break>Dietary modifications<break></break>Surgical exploration<break></break></td><td align="center" rowspan="1" colspan="1">B chylothoraces requiring chest tubes<break></break>Leak site not identified</td></tr></tbody></table><table-wrap-foot><fn><p>L = left; R = right; B = bilateral; MRND = modified radical neck dissection.</p></fn></table-wrap-foot></table-wrap></floats-group></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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