Assessment of edema volume in skin upon injury in a mouse ear model with optical coherence tomography
Identifieur interne : 003829 ( Pmc/Corpus ); précédent : 003828; suivant : 003830Assessment of edema volume in skin upon injury in a mouse ear model with optical coherence tomography
Auteurs : Wan Qin ; Ruikang K. WangSource :
- Lasers in medical science [ 0268-8921 ] ; 2016.
Abstract
Accurate measurement of edema volume is essential for the investigation of tissue response and recovery following a traumatic injury. The measurements must be noninvasive and repetitive over time so as to monitor tissue response throughout the healing process. Such techniques are particularly necessary for the evaluation of therapeutics that are currently in development to suppress or prevent edema formation. In this study, we propose to use optical coherence tomography (OCT) technique to image and quantify edema in a mouse ear model where the injury is induced by a superficial-thickness burn. Extraction of edema volume is achieved by an attenuation compensation algorithm performed on the three-dimensional OCT images, followed by two segmentation procedures. In addition to edema volume, the segmentation method also enables accurate thickness mapping of edematous tissue, which is an important characteristic of the external symptoms of edema. To the best of our knowledge, this is the first method for noninvasively measuring absolute edema volume.
Url:
DOI: 10.1007/s10103-016-1984-x
PubMed: 27282161
PubMed Central: 5287999
Links to Exploration step
PMC:5287999Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Assessment of edema volume in skin upon injury in a mouse ear model with optical coherence tomography</title><author><name sortKey="Qin, Wan" sort="Qin, Wan" uniqKey="Qin W" first="Wan" last="Qin">Wan Qin</name><affiliation><nlm:aff id="A1">Department of Bioengineering, University of Washington, Seattle, WA 98195, USA</nlm:aff></affiliation></author><author><name sortKey="Wang, Ruikang K" sort="Wang, Ruikang K" uniqKey="Wang R" first="Ruikang K." last="Wang">Ruikang K. Wang</name><affiliation><nlm:aff id="A1">Department of Bioengineering, University of Washington, Seattle, WA 98195, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Ophthalmology, University of Washington, Seattle, WA 98109, USA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27282161</idno><idno type="pmc">5287999</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5287999</idno><idno type="RBID">PMC:5287999</idno><idno type="doi">10.1007/s10103-016-1984-x</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">003829</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">003829</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Assessment of edema volume in skin upon injury in a mouse ear model with optical coherence tomography</title><author><name sortKey="Qin, Wan" sort="Qin, Wan" uniqKey="Qin W" first="Wan" last="Qin">Wan Qin</name><affiliation><nlm:aff id="A1">Department of Bioengineering, University of Washington, Seattle, WA 98195, USA</nlm:aff></affiliation></author><author><name sortKey="Wang, Ruikang K" sort="Wang, Ruikang K" uniqKey="Wang R" first="Ruikang K." last="Wang">Ruikang K. Wang</name><affiliation><nlm:aff id="A1">Department of Bioengineering, University of Washington, Seattle, WA 98195, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Ophthalmology, University of Washington, Seattle, WA 98109, USA</nlm:aff></affiliation></author></analytic><series><title level="j">Lasers in medical science</title><idno type="ISSN">0268-8921</idno><idno type="eISSN">1435-604X</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Accurate measurement of edema volume is essential for the investigation of tissue response and recovery following a traumatic injury. The measurements must be noninvasive and repetitive over time so as to monitor tissue response throughout the healing process. Such techniques are particularly necessary for the evaluation of therapeutics that are currently in development to suppress or prevent edema formation. In this study, we propose to use optical coherence tomography (OCT) technique to image and quantify edema in a mouse ear model where the injury is induced by a superficial-thickness burn. Extraction of edema volume is achieved by an attenuation compensation algorithm performed on the three-dimensional OCT images, followed by two segmentation procedures. In addition to edema volume, the segmentation method also enables accurate thickness mapping of edematous tissue, which is an important characteristic of the external symptoms of edema. To the best of our knowledge, this is the first method for noninvasively measuring absolute edema volume.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8611515</journal-id><journal-id journal-id-type="pubmed-jr-id">22447</journal-id><journal-id journal-id-type="nlm-ta">Lasers Med Sci</journal-id><journal-id journal-id-type="iso-abbrev">Lasers Med Sci</journal-id><journal-title-group><journal-title>Lasers in medical science</journal-title></journal-title-group><issn pub-type="ppub">0268-8921</issn><issn pub-type="epub">1435-604X</issn></journal-meta><article-meta><article-id pub-id-type="pmid">27282161</article-id><article-id pub-id-type="pmc">5287999</article-id><article-id pub-id-type="doi">10.1007/s10103-016-1984-x</article-id><article-id pub-id-type="manuscript">NIHMS844147</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Assessment of edema volume in skin upon injury in a mouse ear model with optical coherence tomography</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Qin</surname><given-names>Wan</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Wang</surname><given-names>Ruikang K.</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><pmc-comment>wangrk@uw.edu </pmc-comment>
</contrib></contrib-group><aff id="A1"><label>1</label>Department of Bioengineering, University of Washington, Seattle, WA 98195, USA</aff><aff id="A2"><label>2</label>Department of Ophthalmology, University of Washington, Seattle, WA 98109, USA</aff><pub-date pub-type="nihms-submitted"><day>20</day><month>1</month><year>2017</year></pub-date><pub-date pub-type="epub"><day>09</day><month>6</month><year>2016</year></pub-date><pub-date pub-type="ppub"><month>9</month><year>2016</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>9</month><year>2017</year></pub-date><volume>31</volume><issue>7</issue><fpage>1351</fpage><lpage>1361</lpage><pmc-comment>elocation-id from pubmed: 10.1007/s10103-016-1984-x</pmc-comment>
<abstract><p id="P1">Accurate measurement of edema volume is essential for the investigation of tissue response and recovery following a traumatic injury. The measurements must be noninvasive and repetitive over time so as to monitor tissue response throughout the healing process. Such techniques are particularly necessary for the evaluation of therapeutics that are currently in development to suppress or prevent edema formation. In this study, we propose to use optical coherence tomography (OCT) technique to image and quantify edema in a mouse ear model where the injury is induced by a superficial-thickness burn. Extraction of edema volume is achieved by an attenuation compensation algorithm performed on the three-dimensional OCT images, followed by two segmentation procedures. In addition to edema volume, the segmentation method also enables accurate thickness mapping of edematous tissue, which is an important characteristic of the external symptoms of edema. To the best of our knowledge, this is the first method for noninvasively measuring absolute edema volume.</p></abstract><kwd-group><kwd>Optical coherence tomography</kwd><kwd>Optical microangiography</kwd><kwd>Edema assessment</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Pmc/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003829 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd -nk 003829 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Pmc
|étape= Corpus
|type= RBID
|clé= PMC:5287999
|texte= Assessment of edema volume in skin upon injury in a mouse ear model with optical coherence tomography
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/RBID.i -Sk "pubmed:27282161" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |