Activation and regulation of Toll-Like Receptors (TLRs) by helminth parasites
Identifieur interne : 003828 ( Pmc/Corpus ); précédent : 003827; suivant : 003829Activation and regulation of Toll-Like Receptors (TLRs) by helminth parasites
Auteurs : Priyanka Goel Venugopal ; Thomas B. Nutman ; Roshanak Tolouei SemnaniSource :
- Immunologic Research [ 0257-277X ] ; 2009.
Abstract
Helminth (worm) infections are major public health problems that have important socioeconomic consequences for the more than 2 billion infected individuals. Chronicity (their hallmark) can lead to anemia (in hookworm infection), river blindness (onchcerciasis), cirrhosis (schistosomiasis), and elephantiasis (lymphatic filariasis). Although there have been many studies examining innate immune responses (including TLR expression and function) in response to intracellular pathogens, fewer have examined the interaction of the multicellular helminth parasites and the innate immune system. This review will focus on two “systemic” helminth parasitic infections (lymphatic filariasis and schistosomiasis) and the regulation of TLRs that may contribute to infection outcome.
Url:
DOI: 10.1007/s12026-008-8079-0
PubMed: 18982454
PubMed Central: 3398210
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<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8611087</journal-id><journal-id journal-id-type="pubmed-jr-id">4862</journal-id><journal-id journal-id-type="nlm-ta">Immunol Res</journal-id><journal-id journal-id-type="iso-abbrev">Immunol. Res.</journal-id><journal-title-group><journal-title>Immunologic Research</journal-title></journal-title-group><issn pub-type="ppub">0257-277X</issn><issn pub-type="epub">1559-0755</issn></journal-meta><article-meta><article-id pub-id-type="pmid">18982454</article-id><article-id pub-id-type="pmc">3398210</article-id><article-id pub-id-type="doi">10.1007/s12026-008-8079-0</article-id><article-id pub-id-type="manuscript">NIHMS391077</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Activation and regulation of Toll-Like Receptors (TLRs) by helminth parasites</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Venugopal</surname><given-names>Priyanka Goel</given-names></name></contrib><contrib contrib-type="author"><name><surname>Nutman</surname><given-names>Thomas B.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Semnani</surname><given-names>Roshanak Tolouei</given-names></name></contrib><aff id="A1">Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 4 Center Drive, Room 126, Bethesda, MD 20892-0425, USA</aff></contrib-group><author-notes><corresp id="CR1">R. T. Semnani (✉) Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 4, 4 Center Drive, Room 105, Bethesda, MD 20892-0425, USA, <email>rsemnani@niaid.nih.gov</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>6</day><month>7</month><year>2012</year></pub-date><pub-date pub-type="ppub"><year>2009</year></pub-date><pub-date pub-type="pmc-release"><day>17</day><month>7</month><year>2012</year></pub-date><volume>43</volume><issue>1-3</issue><fpage>252</fpage><lpage>263</lpage><permissions><copyright-statement>© Springer Science+Business Media, LLC 2008</copyright-statement><copyright-year>2008</copyright-year></permissions><abstract><p id="P1">Helminth (worm) infections are major public health problems that have important socioeconomic consequences for the more than 2 billion infected individuals. Chronicity (their hallmark) can lead to anemia (in hookworm infection), river blindness (onchcerciasis), cirrhosis (schistosomiasis), and elephantiasis (lymphatic filariasis). Although there have been many studies examining innate immune responses (including TLR expression and function) in response to intracellular pathogens, fewer have examined the interaction of the multicellular helminth parasites and the innate immune system. This review will focus on two “systemic” helminth parasitic infections (lymphatic filariasis and schistosomiasis) and the regulation of TLRs that may contribute to infection outcome.</p></abstract><kwd-group><kwd>APC</kwd><kwd>Lymphatic filariasis</kwd><kwd>Schistosomiasis</kwd><kwd>Dendritic cells</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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