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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Quality of Life Over Time in Women Diagnosed with Ductal Carcinoma <italic>In situ</italic>, Early-Stage Invasive Breast Cancer, and Age-Matched Controls</title><author><name sortKey="Jeffe, Db" sort="Jeffe, Db" uniqKey="Jeffe D" first="Db" last="Jeffe">Db Jeffe</name><affiliation><nlm:aff id="A1">Division of Health Behavior Research, Department of Medicine, Washington University School of Medicine, St. Louis, MO</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Alvin J. Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine, St. Louis, MO</nlm:aff></affiliation></author><author><name sortKey="Perez, M" sort="Perez, M" uniqKey="Perez M" first="M" last="Pérez">M. Pérez</name><affiliation><nlm:aff id="A1">Division of Health Behavior Research, Department of Medicine, Washington University School of Medicine, St. Louis, MO</nlm:aff></affiliation></author><author><name sortKey="Liu, Y" sort="Liu, Y" uniqKey="Liu Y" first="Y" last="Liu">Y. Liu</name><affiliation><nlm:aff id="A3">Department of Surgery, Washington University School of Medicine, St. Louis, MO</nlm:aff></affiliation></author><author><name sortKey="Collins, Kk" sort="Collins, Kk" uniqKey="Collins K" first="Kk" last="Collins">Kk Collins</name><affiliation><nlm:aff id="A1">Division of Health Behavior Research, Department of Medicine, Washington University School of Medicine, St. Louis, MO</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Alvin J. Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine, St. Louis, MO</nlm:aff></affiliation></author><author><name sortKey="Aft, Rl" sort="Aft, Rl" uniqKey="Aft R" first="Rl" last="Aft">Rl Aft</name><affiliation><nlm:aff id="A2">Alvin J. Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine, St. Louis, MO</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Surgery, Washington University School of Medicine, St. Louis, MO</nlm:aff></affiliation><affiliation><nlm:aff id="A4">John Cochran Veterans Administration Hospital, St. Louis, MO</nlm:aff></affiliation></author><author><name sortKey="Schootman, M" sort="Schootman, M" uniqKey="Schootman M" first="M" last="Schootman">M. Schootman</name><affiliation><nlm:aff id="A1">Division of Health Behavior Research, Department of Medicine, Washington University School of Medicine, St. Louis, MO</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Alvin J. Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine, St. Louis, MO</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22484800</idno><idno type="pmc">3448489</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3448489</idno><idno type="RBID">PMC:3448489</idno><idno type="doi">10.1007/s10549-012-2048-y</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">003747</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">003747</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Quality of Life Over Time in Women Diagnosed with Ductal Carcinoma <italic>In situ</italic>, Early-Stage Invasive Breast Cancer, and Age-Matched Controls</title><author><name sortKey="Jeffe, Db" sort="Jeffe, Db" uniqKey="Jeffe D" first="Db" last="Jeffe">Db Jeffe</name><affiliation><nlm:aff id="A1">Division of Health Behavior Research, Department of Medicine, Washington University School of Medicine, St. Louis, MO</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Alvin J. Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine, St. Louis, MO</nlm:aff></affiliation></author><author><name sortKey="Perez, M" sort="Perez, M" uniqKey="Perez M" first="M" last="Pérez">M. Pérez</name><affiliation><nlm:aff id="A1">Division of Health Behavior Research, Department of Medicine, Washington University School of Medicine, St. Louis, MO</nlm:aff></affiliation></author><author><name sortKey="Liu, Y" sort="Liu, Y" uniqKey="Liu Y" first="Y" last="Liu">Y. Liu</name><affiliation><nlm:aff id="A3">Department of Surgery, Washington University School of Medicine, St. Louis, MO</nlm:aff></affiliation></author><author><name sortKey="Collins, Kk" sort="Collins, Kk" uniqKey="Collins K" first="Kk" last="Collins">Kk Collins</name><affiliation><nlm:aff id="A1">Division of Health Behavior Research, Department of Medicine, Washington University School of Medicine, St. Louis, MO</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Alvin J. Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine, St. Louis, MO</nlm:aff></affiliation></author><author><name sortKey="Aft, Rl" sort="Aft, Rl" uniqKey="Aft R" first="Rl" last="Aft">Rl Aft</name><affiliation><nlm:aff id="A2">Alvin J. Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine, St. Louis, MO</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Surgery, Washington University School of Medicine, St. Louis, MO</nlm:aff></affiliation><affiliation><nlm:aff id="A4">John Cochran Veterans Administration Hospital, St. Louis, MO</nlm:aff></affiliation></author><author><name sortKey="Schootman, M" sort="Schootman, M" uniqKey="Schootman M" first="M" last="Schootman">M. Schootman</name><affiliation><nlm:aff id="A1">Division of Health Behavior Research, Department of Medicine, Washington University School of Medicine, St. Louis, MO</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Alvin J. Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine, St. Louis, MO</nlm:aff></affiliation></author></analytic><series><title level="j">Breast cancer research and treatment</title><idno type="ISSN">0167-6806</idno><idno type="eISSN">1573-7217</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Little is known about quality-of-life (QOL) differences over time between incident ductal carcinoma <italic>in situ</italic> (DCIS) and early-stage invasive breast cancer (EIBC) cases as compared with same-aged women without breast cancer (controls). We prospectively recruited and interviewed 1096 women (16.8% DCIS, 33.3% EIBC [25.7% Stage I, 7.6% Stage IIA], 49.9% controls; mean age 58; 23.7% non-white) a mean 6.7 weeks (T1), and 6.2 (T2), 12.3 (T3), and 24.4 months (T4) after surgery (patients) or screening mammogram (controls). We tested two hypotheses: (1) DCIS patients would report lower levels of QOL compared with controls but would report similar QOL compared with EIBC patients at baseline; and (2) DCIS patients’ QOL would improve during 2-year follow-up and approach levels similar to that of controls faster than EIBC patients. We tested Hypothesis 1 using separate general linear regression models for each of the eight subscales on the RAND 36-item Health Survey, controlling for variables associated with at least one subscale at T1. Both DCIS and EIBC patients reported lower QOL at T1 than controls on all subscales (each p < .05). We tested Hypothesis 2 using generalized estimating equations to examine change in each QOL subscale over time across the three diagnostic groups adjusting for covariates. By T3, physical functioning, role limitations due to physical problems, energy/fatigue, and general health each differed significantly by diagnostic group at <italic>P</italic> < 0.05, due to larger differences between EIBC patients and controls; but DCIS patients no longer differed significantly from controls on any of the QOL subscales. At T4, EIBC patients still reported worse physical functioning (P = 0.0001) and general health (P = 0.0017) than controls, possibly due to lingering treatment effects. DCIS patients’ QOL was similar to that of controls two years after diagnosis, but some aspects of EIBC patients’ QOL remained lower.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8111104</journal-id><journal-id journal-id-type="pubmed-jr-id">1254</journal-id><journal-id journal-id-type="nlm-ta">Breast Cancer Res Treat</journal-id><journal-id journal-id-type="iso-abbrev">Breast Cancer Res. Treat.</journal-id><journal-title-group><journal-title>Breast cancer research and treatment</journal-title></journal-title-group><issn pub-type="ppub">0167-6806</issn><issn pub-type="epub">1573-7217</issn></journal-meta><article-meta><article-id pub-id-type="pmid">22484800</article-id><article-id pub-id-type="pmc">3448489</article-id><article-id pub-id-type="doi">10.1007/s10549-012-2048-y</article-id><article-id pub-id-type="manuscript">NIHMS405138</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Quality of Life Over Time in Women Diagnosed with Ductal Carcinoma <italic>In situ</italic>, Early-Stage Invasive Breast Cancer, and Age-Matched Controls</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Jeffe</surname><given-names>DB</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Pérez</surname><given-names>M</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Liu</surname><given-names>Y</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Collins</surname><given-names>KK</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Aft</surname><given-names>RL</given-names></name><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A3">3</xref><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Schootman</surname><given-names>M</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib></contrib-group><aff id="A1"><label>1</label>Division of Health Behavior Research, Department of Medicine, Washington University School of Medicine, St. Louis, MO</aff><aff id="A2"><label>2</label>Alvin J. Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine, St. Louis, MO</aff><aff id="A3"><label>3</label>Department of Surgery, Washington University School of Medicine, St. Louis, MO</aff><aff id="A4"><label>4</label>John Cochran Veterans Administration Hospital, St. Louis, MO</aff><author-notes><corresp id="cor1">Corresponding Author: Donna B. Jeffe, PhD, Washington University School of Medicine, 4444 Forest Park, Suite 6700, St. Louis, MO 63108, Phone: 314-286-1914; Fax: 314-286-1919; <email>djeffe@dom.wustl.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>5</day><month>9</month><year>2012</year></pub-date><pub-date pub-type="epub"><day>08</day><month>4</month><year>2012</year></pub-date><pub-date pub-type="ppub"><month>7</month><year>2012</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>7</month><year>2013</year></pub-date><volume>134</volume><issue>1</issue><fpage>379</fpage><lpage>391</lpage><abstract><p id="P1">Little is known about quality-of-life (QOL) differences over time between incident ductal carcinoma <italic>in situ</italic> (DCIS) and early-stage invasive breast cancer (EIBC) cases as compared with same-aged women without breast cancer (controls). We prospectively recruited and interviewed 1096 women (16.8% DCIS, 33.3% EIBC [25.7% Stage I, 7.6% Stage IIA], 49.9% controls; mean age 58; 23.7% non-white) a mean 6.7 weeks (T1), and 6.2 (T2), 12.3 (T3), and 24.4 months (T4) after surgery (patients) or screening mammogram (controls). We tested two hypotheses: (1) DCIS patients would report lower levels of QOL compared with controls but would report similar QOL compared with EIBC patients at baseline; and (2) DCIS patients’ QOL would improve during 2-year follow-up and approach levels similar to that of controls faster than EIBC patients. We tested Hypothesis 1 using separate general linear regression models for each of the eight subscales on the RAND 36-item Health Survey, controlling for variables associated with at least one subscale at T1. Both DCIS and EIBC patients reported lower QOL at T1 than controls on all subscales (each p < .05). We tested Hypothesis 2 using generalized estimating equations to examine change in each QOL subscale over time across the three diagnostic groups adjusting for covariates. By T3, physical functioning, role limitations due to physical problems, energy/fatigue, and general health each differed significantly by diagnostic group at <italic>P</italic> < 0.05, due to larger differences between EIBC patients and controls; but DCIS patients no longer differed significantly from controls on any of the QOL subscales. At T4, EIBC patients still reported worse physical functioning (P = 0.0001) and general health (P = 0.0017) than controls, possibly due to lingering treatment effects. DCIS patients’ QOL was similar to that of controls two years after diagnosis, but some aspects of EIBC patients’ QOL remained lower.</p></abstract><kwd-group><kwd>Breast cancer</kwd><kwd>ductal carcinoma <italic>in situ</italic> (DCIS)</kwd><kwd>early-stage invasive breast cancer</kwd><kwd>quality of life</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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