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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The distribution of cutaneous metastases correlates with local immunologic milieu</title><author><name sortKey="Schulman, Joshua M" sort="Schulman, Joshua M" uniqKey="Schulman J" first="Joshua M." last="Schulman">Joshua M. Schulman</name><affiliation><nlm:aff id="A1">Department of Dermatology, University of California, San Francisco</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Pathology, University of California, San Francisco</nlm:aff></affiliation></author><author><name sortKey="Pauli, Mariela L" sort="Pauli, Mariela L" uniqKey="Pauli M" first="Mariela L." last="Pauli">Mariela L. Pauli</name><affiliation><nlm:aff id="A1">Department of Dermatology, University of California, San Francisco</nlm:aff></affiliation></author><author><name sortKey="Neuhaus, Isaac M" sort="Neuhaus, Isaac M" uniqKey="Neuhaus I" first="Isaac M." last="Neuhaus">Isaac M. Neuhaus</name><affiliation><nlm:aff id="A1">Department of Dermatology, University of California, San Francisco</nlm:aff></affiliation></author><author><name sortKey="Rodriguez, Roberto Sanchez" sort="Rodriguez, Roberto Sanchez" uniqKey="Rodriguez R" first="Roberto Sanchez" last="Rodriguez">Roberto Sanchez Rodriguez</name><affiliation><nlm:aff id="A1">Department of Dermatology, University of California, San Francisco</nlm:aff></affiliation></author><author><name sortKey="Taravati, Keyon" sort="Taravati, Keyon" uniqKey="Taravati K" first="Keyon" last="Taravati">Keyon Taravati</name><affiliation><nlm:aff id="A1">Department of Dermatology, University of California, San Francisco</nlm:aff></affiliation></author><author><name sortKey="Shin, Uk Sok" sort="Shin, Uk Sok" uniqKey="Shin U" first="Uk Sok" last="Shin">Uk Sok Shin</name><affiliation><nlm:aff id="A1">Department of Dermatology, University of California, San Francisco</nlm:aff></affiliation></author><author><name sortKey="Mccalmont, Timothy H" sort="Mccalmont, Timothy H" uniqKey="Mccalmont T" first="Timothy H." last="Mccalmont">Timothy H. Mccalmont</name><affiliation><nlm:aff id="A1">Department of Dermatology, University of California, San Francisco</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Pathology, University of California, San Francisco</nlm:aff></affiliation></author><author><name sortKey="Rosenblum, Michael D" sort="Rosenblum, Michael D" uniqKey="Rosenblum M" first="Michael D." last="Rosenblum">Michael D. Rosenblum</name><affiliation><nlm:aff id="A1">Department of Dermatology, University of California, San Francisco</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26778012</idno><idno type="pmc">4761273</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4761273</idno><idno type="RBID">PMC:4761273</idno><idno type="doi">10.1016/j.jaad.2015.10.012</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">003728</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">003728</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The distribution of cutaneous metastases correlates with local immunologic milieu</title><author><name sortKey="Schulman, Joshua M" sort="Schulman, Joshua M" uniqKey="Schulman J" first="Joshua M." last="Schulman">Joshua M. Schulman</name><affiliation><nlm:aff id="A1">Department of Dermatology, University of California, San Francisco</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Pathology, University of California, San Francisco</nlm:aff></affiliation></author><author><name sortKey="Pauli, Mariela L" sort="Pauli, Mariela L" uniqKey="Pauli M" first="Mariela L." last="Pauli">Mariela L. Pauli</name><affiliation><nlm:aff id="A1">Department of Dermatology, University of California, San Francisco</nlm:aff></affiliation></author><author><name sortKey="Neuhaus, Isaac M" sort="Neuhaus, Isaac M" uniqKey="Neuhaus I" first="Isaac M." last="Neuhaus">Isaac M. Neuhaus</name><affiliation><nlm:aff id="A1">Department of Dermatology, University of California, San Francisco</nlm:aff></affiliation></author><author><name sortKey="Rodriguez, Roberto Sanchez" sort="Rodriguez, Roberto Sanchez" uniqKey="Rodriguez R" first="Roberto Sanchez" last="Rodriguez">Roberto Sanchez Rodriguez</name><affiliation><nlm:aff id="A1">Department of Dermatology, University of California, San Francisco</nlm:aff></affiliation></author><author><name sortKey="Taravati, Keyon" sort="Taravati, Keyon" uniqKey="Taravati K" first="Keyon" last="Taravati">Keyon Taravati</name><affiliation><nlm:aff id="A1">Department of Dermatology, University of California, San Francisco</nlm:aff></affiliation></author><author><name sortKey="Shin, Uk Sok" sort="Shin, Uk Sok" uniqKey="Shin U" first="Uk Sok" last="Shin">Uk Sok Shin</name><affiliation><nlm:aff id="A1">Department of Dermatology, University of California, San Francisco</nlm:aff></affiliation></author><author><name sortKey="Mccalmont, Timothy H" sort="Mccalmont, Timothy H" uniqKey="Mccalmont T" first="Timothy H." last="Mccalmont">Timothy H. Mccalmont</name><affiliation><nlm:aff id="A1">Department of Dermatology, University of California, San Francisco</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Pathology, University of California, San Francisco</nlm:aff></affiliation></author><author><name sortKey="Rosenblum, Michael D" sort="Rosenblum, Michael D" uniqKey="Rosenblum M" first="Michael D." last="Rosenblum">Michael D. Rosenblum</name><affiliation><nlm:aff id="A1">Department of Dermatology, University of California, San Francisco</nlm:aff></affiliation></author></analytic><series><title level="j">Journal of the American Academy of Dermatology</title><idno type="ISSN">0190-9622</idno><idno type="eISSN">1097-6787</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title><p id="P1">Metastases to the skin are found with increased frequency at certain sites, such as the scalp, but the biological factors that influence this distribution are not understood.</p></sec><sec id="S2"><title>Objective</title><p id="P2">We aimed to compare the proportional frequency of metastases at various cutaneous locations with the immunologic microenvironments at those sites.</p></sec><sec id="S3"><title>Methods</title><p id="P3">We retrospectively identified all biopsies of cutaneous metastases diagnosed at our institution from 1991 to 2014 (n = 1984) and mapped their anatomic distribution while controlling for regional surface area. Using a separate, mapped cohort of normal skin samples (n = 140), we measured the density of regulatory T cells (Tregs), CD4+ effector T cells, and CD8+ T cells by flow cytometry.</p></sec><sec id="S4"><title>Results</title><p id="P4">Per unit surface area, cutaneous metastases arise most commonly on the head and neck, followed by the trunk, upper extremities, and lower extremities, respectively. Sites with more frequent metastases tend to contain a greater density of Tregs and a lower proportion of CD8+ T cells (p < 0.05).</p></sec><sec id="S5"><title>Limitations</title><p id="P5">Immunologic factors were only assessed in control tissue and were not measured from patients with metastatic disease in this correlative single-center study.</p></sec><sec id="S6"><title>Conclusion</title><p id="P6">The distribution of cutaneous metastases follows the distribution of regulatory and effector T cells in skin. Further studies are required to prove a mechanistic association between local immunologic factors and the development of cutaneous metastases.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">7907132</journal-id><journal-id journal-id-type="pubmed-jr-id">4671</journal-id><journal-id journal-id-type="nlm-ta">J Am Acad Dermatol</journal-id><journal-id journal-id-type="iso-abbrev">J. Am. Acad. Dermatol.</journal-id><journal-title-group><journal-title>Journal of the American Academy of Dermatology</journal-title></journal-title-group><issn pub-type="ppub">0190-9622</issn><issn pub-type="epub">1097-6787</issn></journal-meta><article-meta><article-id pub-id-type="pmid">26778012</article-id><article-id pub-id-type="pmc">4761273</article-id><article-id pub-id-type="doi">10.1016/j.jaad.2015.10.012</article-id><article-id pub-id-type="manuscript">NIHMS733319</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>The distribution of cutaneous metastases correlates with local immunologic milieu</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Schulman</surname><given-names>Joshua M.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Pauli</surname><given-names>Mariela L.</given-names></name><degrees>MS</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Neuhaus</surname><given-names>Isaac M.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Rodriguez</surname><given-names>Roberto Sanchez</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Taravati</surname><given-names>Keyon</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Shin</surname><given-names>Uk Sok</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>McCalmont</surname><given-names>Timothy H.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Rosenblum</surname><given-names>Michael D.</given-names></name><degrees>MD PhD</degrees><xref ref-type="aff" rid="A1">1</xref></contrib></contrib-group><aff id="A1"><label>1</label>Department of Dermatology, University of California, San Francisco</aff><aff id="A2"><label>2</label>Department of Pathology, University of California, San Francisco</aff><author-notes><corresp id="cor1">Corresponding author: Michael D. Rosenblum, 1701 Divisadero Street, San Francisco, CA 94115, Telephone (415) 353-7891, Fax (415) 353-7870, <email>Michael.Rosenblum@ucsf.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>28</day><month>10</month><year>2015</year></pub-date><pub-date pub-type="epub"><day>09</day><month>1</month><year>2016</year></pub-date><pub-date pub-type="ppub"><month>3</month><year>2016</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>3</month><year>2017</year></pub-date><volume>74</volume><issue>3</issue><fpage>470</fpage><lpage>476</lpage><pmc-comment>elocation-id from pubmed: 10.1016/j.jaad.2015.10.012</pmc-comment>
<abstract><sec id="S1"><title>Background</title><p id="P1">Metastases to the skin are found with increased frequency at certain sites, such as the scalp, but the biological factors that influence this distribution are not understood.</p></sec><sec id="S2"><title>Objective</title><p id="P2">We aimed to compare the proportional frequency of metastases at various cutaneous locations with the immunologic microenvironments at those sites.</p></sec><sec id="S3"><title>Methods</title><p id="P3">We retrospectively identified all biopsies of cutaneous metastases diagnosed at our institution from 1991 to 2014 (n = 1984) and mapped their anatomic distribution while controlling for regional surface area. Using a separate, mapped cohort of normal skin samples (n = 140), we measured the density of regulatory T cells (Tregs), CD4+ effector T cells, and CD8+ T cells by flow cytometry.</p></sec><sec id="S4"><title>Results</title><p id="P4">Per unit surface area, cutaneous metastases arise most commonly on the head and neck, followed by the trunk, upper extremities, and lower extremities, respectively. Sites with more frequent metastases tend to contain a greater density of Tregs and a lower proportion of CD8+ T cells (p < 0.05).</p></sec><sec id="S5"><title>Limitations</title><p id="P5">Immunologic factors were only assessed in control tissue and were not measured from patients with metastatic disease in this correlative single-center study.</p></sec><sec id="S6"><title>Conclusion</title><p id="P6">The distribution of cutaneous metastases follows the distribution of regulatory and effector T cells in skin. Further studies are required to prove a mechanistic association between local immunologic factors and the development of cutaneous metastases.</p></sec></abstract><kwd-group><kwd>metastatic cancer</kwd><kwd>cutaneous metastasis</kwd><kwd>anatomic distribution</kwd><kwd>immunology</kwd><kwd>regulatory T cells</kwd><kwd>effector T cells</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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