Wolbachia heat shock protein 60 induces pro-inflammatory cytokines and apoptosis in monocytes in vitro
Identifieur interne : 003412 ( Pmc/Corpus ); précédent : 003411; suivant : 003413Wolbachia heat shock protein 60 induces pro-inflammatory cytokines and apoptosis in monocytes in vitro
Auteurs : Vijayan Kamalakannan ; Sreenivas Kirthika ; Kalyanaraman Haripriya ; Subash Babu ; Rangarajan Badri NarayananSource :
- Microbes and infection / Institut Pasteur [ 1286-4579 ] ; 2012.
Abstract
Recombinant
Url:
DOI: 10.1016/j.micinf.2012.01.008
PubMed: 22326972
PubMed Central: 3512103
Links to Exploration step
PMC:3512103Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en"><italic>Wolbachia</italic>
heat shock protein 60 induces pro-inflammatory cytokines and apoptosis in monocytes in vitro</title>
<author><name sortKey="Kamalakannan, Vijayan" sort="Kamalakannan, Vijayan" uniqKey="Kamalakannan V" first="Vijayan" last="Kamalakannan">Vijayan Kamalakannan</name>
<affiliation><nlm:aff id="A1"> Centre for Biotechnology, Anna University, Chennai 600025, India</nlm:aff>
</affiliation>
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<author><name sortKey="Kirthika, Sreenivas" sort="Kirthika, Sreenivas" uniqKey="Kirthika S" first="Sreenivas" last="Kirthika">Sreenivas Kirthika</name>
<affiliation><nlm:aff id="A1"> Centre for Biotechnology, Anna University, Chennai 600025, India</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Haripriya, Kalyanaraman" sort="Haripriya, Kalyanaraman" uniqKey="Haripriya K" first="Kalyanaraman" last="Haripriya">Kalyanaraman Haripriya</name>
<affiliation><nlm:aff id="A1"> Centre for Biotechnology, Anna University, Chennai 600025, India</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Babu, Subash" sort="Babu, Subash" uniqKey="Babu S" first="Subash" last="Babu">Subash Babu</name>
<affiliation><nlm:aff id="A2"> NIH-TRC-ICER SAIC-Frederick Inc., National Cancer Institute at Frederic, Chetpet, Chennai, India</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Narayanan, Rangarajan Badri" sort="Narayanan, Rangarajan Badri" uniqKey="Narayanan R" first="Rangarajan Badri" last="Narayanan">Rangarajan Badri Narayanan</name>
<affiliation><nlm:aff id="A1"> Centre for Biotechnology, Anna University, Chennai 600025, India</nlm:aff>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main"><italic>Wolbachia</italic>
heat shock protein 60 induces pro-inflammatory cytokines and apoptosis in monocytes in vitro</title>
<author><name sortKey="Kamalakannan, Vijayan" sort="Kamalakannan, Vijayan" uniqKey="Kamalakannan V" first="Vijayan" last="Kamalakannan">Vijayan Kamalakannan</name>
<affiliation><nlm:aff id="A1"> Centre for Biotechnology, Anna University, Chennai 600025, India</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kirthika, Sreenivas" sort="Kirthika, Sreenivas" uniqKey="Kirthika S" first="Sreenivas" last="Kirthika">Sreenivas Kirthika</name>
<affiliation><nlm:aff id="A1"> Centre for Biotechnology, Anna University, Chennai 600025, India</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Haripriya, Kalyanaraman" sort="Haripriya, Kalyanaraman" uniqKey="Haripriya K" first="Kalyanaraman" last="Haripriya">Kalyanaraman Haripriya</name>
<affiliation><nlm:aff id="A1"> Centre for Biotechnology, Anna University, Chennai 600025, India</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Babu, Subash" sort="Babu, Subash" uniqKey="Babu S" first="Subash" last="Babu">Subash Babu</name>
<affiliation><nlm:aff id="A2"> NIH-TRC-ICER SAIC-Frederick Inc., National Cancer Institute at Frederic, Chetpet, Chennai, India</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Narayanan, Rangarajan Badri" sort="Narayanan, Rangarajan Badri" uniqKey="Narayanan R" first="Rangarajan Badri" last="Narayanan">Rangarajan Badri Narayanan</name>
<affiliation><nlm:aff id="A1"> Centre for Biotechnology, Anna University, Chennai 600025, India</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Microbes and infection / Institut Pasteur</title>
<idno type="ISSN">1286-4579</idno>
<idno type="eISSN">1769-714X</idno>
<imprint><date when="2012">2012</date>
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<front><div type="abstract" xml:lang="en"><p id="P1">Recombinant <italic>Wolbachia</italic>
heat shock protein 60 (rWmhsp60) induces gene expression of pro-inflammatory cytokines IL-1β, IL-6 and TNF-α in human monocytic cell line THP-1. In addition, it inhibits the phagocytic activity and does not alter the nitric oxide production by differentiated THP-1 macrophages, which corroborates with no significant change in inducible nitric oxide synthase gene expression in rWmhsp60 treated THP-1 monocytes. Further, 24 h stimulation of peripheral blood mononuclear cells from normal individuals by rWmhsp60 reveals that monocytes enter the late apoptotic stage, while lymphocytes do not show apoptosis. Thus these findings suggest that rWmhsp60 may contribute to inflammation mediated monocyte dysfunction in filarial pathogenesis.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">100883508</journal-id>
<journal-id journal-id-type="pubmed-jr-id">21592</journal-id>
<journal-id journal-id-type="nlm-ta">Microbes Infect</journal-id>
<journal-id journal-id-type="iso-abbrev">Microbes Infect.</journal-id>
<journal-title-group><journal-title>Microbes and infection / Institut Pasteur</journal-title>
</journal-title-group>
<issn pub-type="ppub">1286-4579</issn>
<issn pub-type="epub">1769-714X</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">22326972</article-id>
<article-id pub-id-type="pmc">3512103</article-id>
<article-id pub-id-type="doi">10.1016/j.micinf.2012.01.008</article-id>
<article-id pub-id-type="manuscript">NIHMS423927</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title><italic>Wolbachia</italic>
heat shock protein 60 induces pro-inflammatory cytokines and apoptosis in monocytes in vitro</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Kamalakannan</surname>
<given-names>Vijayan</given-names>
</name>
<xref ref-type="aff" rid="A1">a</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kirthika</surname>
<given-names>Sreenivas</given-names>
</name>
<xref ref-type="aff" rid="A1">a</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Haripriya</surname>
<given-names>Kalyanaraman</given-names>
</name>
<xref ref-type="aff" rid="A1">a</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Babu</surname>
<given-names>Subash</given-names>
</name>
<xref ref-type="aff" rid="A2">b</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Narayanan</surname>
<given-names>Rangarajan Badri</given-names>
</name>
<xref ref-type="aff" rid="A1">a</xref>
<xref ref-type="corresp" rid="CR1">*</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>a</label>
Centre for Biotechnology, Anna University, Chennai 600025, India</aff>
<aff id="A2"><label>b</label>
NIH-TRC-ICER SAIC-Frederick Inc., National Cancer Institute at Frederic, Chetpet, Chennai, India</aff>
<author-notes><corresp id="CR1"><label>*</label>
Corresponding author. Tel.: +91 44 22350772; fax: +91 44 22350299. <email>rbn@annauniv.edu</email>
, <email>arbeen09@gmail.com</email>
(R.B. Narayanan).</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>27</day>
<month>11</month>
<year>2012</year>
</pub-date>
<pub-date pub-type="epub"><day>28</day>
<month>1</month>
<year>2012</year>
</pub-date>
<pub-date pub-type="ppub"><month>7</month>
<year>2012</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>03</day>
<month>12</month>
<year>2012</year>
</pub-date>
<volume>14</volume>
<issue>7-8</issue>
<fpage>610</fpage>
<lpage>618</lpage>
<permissions><copyright-statement>© 2012 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.</copyright-statement>
<copyright-year>2012</copyright-year>
</permissions>
<abstract><p id="P1">Recombinant <italic>Wolbachia</italic>
heat shock protein 60 (rWmhsp60) induces gene expression of pro-inflammatory cytokines IL-1β, IL-6 and TNF-α in human monocytic cell line THP-1. In addition, it inhibits the phagocytic activity and does not alter the nitric oxide production by differentiated THP-1 macrophages, which corroborates with no significant change in inducible nitric oxide synthase gene expression in rWmhsp60 treated THP-1 monocytes. Further, 24 h stimulation of peripheral blood mononuclear cells from normal individuals by rWmhsp60 reveals that monocytes enter the late apoptotic stage, while lymphocytes do not show apoptosis. Thus these findings suggest that rWmhsp60 may contribute to inflammation mediated monocyte dysfunction in filarial pathogenesis.</p>
</abstract>
<kwd-group><kwd><italic>Wolbachia</italic>
</kwd>
<kwd>Filariasis</kwd>
<kwd>Cytokines</kwd>
<kwd>Monocytes</kwd>
<kwd>Heat shock proteins</kwd>
<kwd>Apoptosis</kwd>
</kwd-group>
<funding-group><award-group><funding-source country="United States">National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID</funding-source>
<award-id>Z99 AI999999 || AI</award-id>
</award-group>
</funding-group>
</article-meta>
</front>
</pmc>
</record>
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