LymphedemaV1, Pmc, Corpus, bibRecord, 003411

Recombinant Wolbachia heat shock protein 60 (HSP60) mediated immune responses in patients with lymphatic filariasis

Identifieur interne : 003411 ( Pmc/Corpus ); précédent : 003410; suivant : 003412

Recombinant Wolbachia heat shock protein 60 (HSP60) mediated immune responses in patients with lymphatic filariasis

Auteurs : Chandanapurath Shiny ; Nagampalli S. A. Krushna ; Subash Babu ; S. Elango ; Guruswamy Manokaran ; Rangarajan Badri Narayanan

Source :

Microbes and infection / Institut Pasteur [ 1286-4579 ] ; 2011.

RBID : PMC:3515687

Abstract

Wolbachia, an endosymbiont present in filarial nematodes, have been implicated in a variety of roles, including the worm development and survival. Elucidation of the role of Wolbachia in filarial nematode biology and pathogenesis has become the focus of many studies and its contribution to parasite survival or immune response is still unclear. Recombinant Wolbachia HSP60 decreases T cell activation and lymphoproliferation in filarial infected people compared to endemic controls as observed by the assessment of T cell activation markers and cytokine responses in the peripheral blood mononuclear cells. Reduced T cell activation may be linked to T regulatory cell activity since it is associated with increased expression of CTLA4 and CD25 on CD4⁺ T cells in filarial infected group upon stimulation with recombinant Wolbachia HSP60. In addition, elevated interleukin-10 and TGF-β cytokines corroborate the reduced CD4⁺ T cell activation and interferon-γ observed upon recombinant Wolbachia HSP60 stimulation in filarial patients. Hence, these findings indicate that Wolbachia HSP60 may also contribute to the immune modulation seen in filarial patients.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3515687

DOI: 10.1016/j.micinf.2011.07.004
PubMed: 21827871
PubMed Central: 3515687

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PMC:3515687

Le document en format XML

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 heat shock protein 60 (HSP60) mediated immune responses in patients with lymphatic filariasis</title>
<author><name sortKey="Shiny, Chandanapurath" sort="Shiny, Chandanapurath" uniqKey="Shiny C" first="Chandanapurath" last="Shiny">Chandanapurath Shiny</name>
<affiliation><nlm:aff id="A1">Centre for Biotechnology, Anna University, Chennai 600025, India</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Krushna, Nagampalli S A" sort="Krushna, Nagampalli S A" uniqKey="Krushna N" first="Nagampalli S. A." last="Krushna">Nagampalli S. A. Krushna</name>
<affiliation><nlm:aff id="A1">Centre for Biotechnology, Anna University, Chennai 600025, India</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Babu, Subash" sort="Babu, Subash" uniqKey="Babu S" first="Subash" last="Babu">Subash Babu</name>
<affiliation><nlm:aff id="A2">NIH-TRC-ICER SAIC-Frederick Inc., National Cancer Institute at Frederick, Chetpet, Chennai, India</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Elango, S" sort="Elango, S" uniqKey="Elango S" first="S." last="Elango">S. Elango</name>
<affiliation><nlm:aff id="A3">Department of Public Health and Preventive Medicine, Government of Tamil Nadu, Chennai, India</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Manokaran, Guruswamy" sort="Manokaran, Guruswamy" uniqKey="Manokaran G" first="Guruswamy" last="Manokaran">Guruswamy Manokaran</name>
<affiliation><nlm:aff id="A4">Apollo Hospital, Greams Road, Chennai, India</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Narayanan, Rangarajan Badri" sort="Narayanan, Rangarajan Badri" uniqKey="Narayanan R" first="Rangarajan Badri" last="Narayanan">Rangarajan Badri Narayanan</name>
<affiliation><nlm:aff id="A1">Centre for Biotechnology, Anna University, Chennai 600025, India</nlm:aff>
</affiliation>
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<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3515687</idno>
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<date when="2011">2011</date>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Recombinant <italic>Wolbachia</italic>
 heat shock protein 60 (HSP60) mediated immune responses in patients with lymphatic filariasis</title>
<author><name sortKey="Shiny, Chandanapurath" sort="Shiny, Chandanapurath" uniqKey="Shiny C" first="Chandanapurath" last="Shiny">Chandanapurath Shiny</name>
<affiliation><nlm:aff id="A1">Centre for Biotechnology, Anna University, Chennai 600025, India</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Krushna, Nagampalli S A" sort="Krushna, Nagampalli S A" uniqKey="Krushna N" first="Nagampalli S. A." last="Krushna">Nagampalli S. A. Krushna</name>
<affiliation><nlm:aff id="A1">Centre for Biotechnology, Anna University, Chennai 600025, India</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Babu, Subash" sort="Babu, Subash" uniqKey="Babu S" first="Subash" last="Babu">Subash Babu</name>
<affiliation><nlm:aff id="A2">NIH-TRC-ICER SAIC-Frederick Inc., National Cancer Institute at Frederick, Chetpet, Chennai, India</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Elango, S" sort="Elango, S" uniqKey="Elango S" first="S." last="Elango">S. Elango</name>
<affiliation><nlm:aff id="A3">Department of Public Health and Preventive Medicine, Government of Tamil Nadu, Chennai, India</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Manokaran, Guruswamy" sort="Manokaran, Guruswamy" uniqKey="Manokaran G" first="Guruswamy" last="Manokaran">Guruswamy Manokaran</name>
<affiliation><nlm:aff id="A4">Apollo Hospital, Greams Road, Chennai, India</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Narayanan, Rangarajan Badri" sort="Narayanan, Rangarajan Badri" uniqKey="Narayanan R" first="Rangarajan Badri" last="Narayanan">Rangarajan Badri Narayanan</name>
<affiliation><nlm:aff id="A1">Centre for Biotechnology, Anna University, Chennai 600025, India</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Microbes and infection / Institut Pasteur</title>
<idno type="ISSN">1286-4579</idno>
<idno type="eISSN">1769-714X</idno>
<imprint><date when="2011">2011</date>
</imprint>
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<front><div type="abstract" xml:lang="en"><p id="P1"><italic>Wolbachia</italic>
, an endosymbiont present in filarial nematodes, have been implicated in a variety of roles, including the worm development and survival. Elucidation of the role of <italic>Wolbachia</italic>
 in filarial nematode biology and pathogenesis has become the focus of many studies and its contribution to parasite survival or immune response is still unclear. Recombinant <italic>Wolbachia</italic>
 HSP60 decreases T cell activation and lymphoproliferation in filarial infected people compared to endemic controls as observed by the assessment of T cell activation markers and cytokine responses in the peripheral blood mononuclear cells. Reduced T cell activation may be linked to T regulatory cell activity since it is associated with increased expression of CTLA4 and CD25 on CD4<sup>+</sup>
 T cells in filarial infected group upon stimulation with recombinant <italic>Wolbachia</italic>
 HSP60. In addition, elevated interleukin-10 and TGF-β cytokines corroborate the reduced CD4<sup>+</sup>
 T cell activation and interferon-γ observed upon recombinant <italic>Wolbachia</italic>
 HSP60 stimulation in filarial patients. Hence, these findings indicate that <italic>Wolbachia</italic>
 HSP60 may also contribute to the immune modulation seen in filarial patients.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
  <pmc-dir>properties manuscript</pmc-dir>
  <front><journal-meta><journal-id journal-id-type="nlm-journal-id">100883508</journal-id>
<journal-id journal-id-type="pubmed-jr-id">21592</journal-id>
<journal-id journal-id-type="nlm-ta">Microbes Infect</journal-id>
<journal-id journal-id-type="iso-abbrev">Microbes Infect.</journal-id>
<journal-title-group><journal-title>Microbes and infection / Institut Pasteur</journal-title>
</journal-title-group>
<issn pub-type="ppub">1286-4579</issn>
<issn pub-type="epub">1769-714X</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">21827871</article-id>
<article-id pub-id-type="pmc">3515687</article-id>
<article-id pub-id-type="doi">10.1016/j.micinf.2011.07.004</article-id>
<article-id pub-id-type="manuscript">NIHMS423940</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Recombinant <italic>Wolbachia</italic>
 heat shock protein 60 (HSP60) mediated immune responses in patients with lymphatic filariasis</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Shiny</surname>
<given-names>Chandanapurath</given-names>
</name>
<xref ref-type="aff" rid="A1">a</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Krushna</surname>
<given-names>Nagampalli S.A.</given-names>
</name>
<xref ref-type="aff" rid="A1">a</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Babu</surname>
<given-names>Subash</given-names>
</name>
<xref ref-type="aff" rid="A2">b</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Elango</surname>
<given-names>S.</given-names>
</name>
<xref ref-type="aff" rid="A3">c</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Manokaran</surname>
<given-names>Guruswamy</given-names>
</name>
<xref ref-type="aff" rid="A4">d</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Narayanan</surname>
<given-names>Rangarajan Badri</given-names>
</name>
<xref ref-type="aff" rid="A1">a</xref>
<xref rid="FN1" ref-type="author-notes">*</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>a</label>
Centre for Biotechnology, Anna University, Chennai 600025, India</aff>
<aff id="A2"><label>b</label>
NIH-TRC-ICER SAIC-Frederick Inc., National Cancer Institute at Frederick, Chetpet, Chennai, India</aff>
<aff id="A3"><label>c</label>
Department of Public Health and Preventive Medicine, Government of Tamil Nadu, Chennai, India</aff>
<aff id="A4"><label>d</label>
Apollo Hospital, Greams Road, Chennai, India</aff>
<author-notes><corresp id="FN1"><label>*</label>
Corresponding author. Tel.: +91 44 22350772; fax: +91 44 22350299. <email>rbn@annauniv.edu</email>
 (R.B. Narayanan)</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>27</day>
<month>11</month>
<year>2012</year>
</pub-date>
<pub-date pub-type="epub"><day>23</day>
<month>7</month>
<year>2011</year>
</pub-date>
<pub-date pub-type="ppub"><month>12</month>
<year>2011</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>06</day>
<month>12</month>
<year>2012</year>
</pub-date>
<volume>13</volume>
<issue>14-15</issue>
<fpage>1221</fpage>
<lpage>1231</lpage>
<permissions><copyright-statement>© 2011 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.</copyright-statement>
<copyright-year>2011</copyright-year>
</permissions>
<abstract><p id="P1"><italic>Wolbachia</italic>
, an endosymbiont present in filarial nematodes, have been implicated in a variety of roles, including the worm development and survival. Elucidation of the role of <italic>Wolbachia</italic>
 in filarial nematode biology and pathogenesis has become the focus of many studies and its contribution to parasite survival or immune response is still unclear. Recombinant <italic>Wolbachia</italic>
 HSP60 decreases T cell activation and lymphoproliferation in filarial infected people compared to endemic controls as observed by the assessment of T cell activation markers and cytokine responses in the peripheral blood mononuclear cells. Reduced T cell activation may be linked to T regulatory cell activity since it is associated with increased expression of CTLA4 and CD25 on CD4<sup>+</sup>
 T cells in filarial infected group upon stimulation with recombinant <italic>Wolbachia</italic>
 HSP60. In addition, elevated interleukin-10 and TGF-β cytokines corroborate the reduced CD4<sup>+</sup>
 T cell activation and interferon-γ observed upon recombinant <italic>Wolbachia</italic>
 HSP60 stimulation in filarial patients. Hence, these findings indicate that <italic>Wolbachia</italic>
 HSP60 may also contribute to the immune modulation seen in filarial patients.</p>
</abstract>
<kwd-group><kwd><italic>Wolbachia</italic>
</kwd>
<kwd>Immune modulation</kwd>
<kwd>Filaria</kwd>
<kwd><italic>Brugia malayi</italic>
</kwd>
<kwd>Cytokines</kwd>
<kwd>T cells</kwd>
</kwd-group>
<funding-group><award-group><funding-source country="United States">National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID</funding-source>
<award-id>Z99 AI999999 || AI</award-id>
</award-group>
</funding-group>
</article-meta>
</front>
</pmc>
</record>

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Recombinant Wolbachia heat shock protein 60 (HSP60) mediated immune responses in patients with lymphatic filariasis

Recombinant Wolbachia heat shock protein 60 (HSP60) mediated immune responses in patients with lymphatic filariasis

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Abstract

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