Recombinant Wolbachia heat shock protein 60 (HSP60) mediated immune responses in patients with lymphatic filariasis
Identifieur interne : 003411 ( Pmc/Corpus ); précédent : 003410; suivant : 003412Recombinant Wolbachia heat shock protein 60 (HSP60) mediated immune responses in patients with lymphatic filariasis
Auteurs : Chandanapurath Shiny ; Nagampalli S. A. Krushna ; Subash Babu ; S. Elango ; Guruswamy Manokaran ; Rangarajan Badri NarayananSource :
- Microbes and infection / Institut Pasteur [ 1286-4579 ] ; 2011.
Abstract
Url:
DOI: 10.1016/j.micinf.2011.07.004
PubMed: 21827871
PubMed Central: 3515687
Links to Exploration step
PMC:3515687Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Recombinant <italic>Wolbachia</italic>
heat shock protein 60 (HSP60) mediated immune responses in patients with lymphatic filariasis</title>
<author><name sortKey="Shiny, Chandanapurath" sort="Shiny, Chandanapurath" uniqKey="Shiny C" first="Chandanapurath" last="Shiny">Chandanapurath Shiny</name>
<affiliation><nlm:aff id="A1">Centre for Biotechnology, Anna University, Chennai 600025, India</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Krushna, Nagampalli S A" sort="Krushna, Nagampalli S A" uniqKey="Krushna N" first="Nagampalli S. A." last="Krushna">Nagampalli S. A. Krushna</name>
<affiliation><nlm:aff id="A1">Centre for Biotechnology, Anna University, Chennai 600025, India</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Babu, Subash" sort="Babu, Subash" uniqKey="Babu S" first="Subash" last="Babu">Subash Babu</name>
<affiliation><nlm:aff id="A2">NIH-TRC-ICER SAIC-Frederick Inc., National Cancer Institute at Frederick, Chetpet, Chennai, India</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Elango, S" sort="Elango, S" uniqKey="Elango S" first="S." last="Elango">S. Elango</name>
<affiliation><nlm:aff id="A3">Department of Public Health and Preventive Medicine, Government of Tamil Nadu, Chennai, India</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Manokaran, Guruswamy" sort="Manokaran, Guruswamy" uniqKey="Manokaran G" first="Guruswamy" last="Manokaran">Guruswamy Manokaran</name>
<affiliation><nlm:aff id="A4">Apollo Hospital, Greams Road, Chennai, India</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Narayanan, Rangarajan Badri" sort="Narayanan, Rangarajan Badri" uniqKey="Narayanan R" first="Rangarajan Badri" last="Narayanan">Rangarajan Badri Narayanan</name>
<affiliation><nlm:aff id="A1">Centre for Biotechnology, Anna University, Chennai 600025, India</nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">21827871</idno>
<idno type="pmc">3515687</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3515687</idno>
<idno type="RBID">PMC:3515687</idno>
<idno type="doi">10.1016/j.micinf.2011.07.004</idno>
<date when="2011">2011</date>
<idno type="wicri:Area/Pmc/Corpus">003411</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">003411</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Recombinant <italic>Wolbachia</italic>
heat shock protein 60 (HSP60) mediated immune responses in patients with lymphatic filariasis</title>
<author><name sortKey="Shiny, Chandanapurath" sort="Shiny, Chandanapurath" uniqKey="Shiny C" first="Chandanapurath" last="Shiny">Chandanapurath Shiny</name>
<affiliation><nlm:aff id="A1">Centre for Biotechnology, Anna University, Chennai 600025, India</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Krushna, Nagampalli S A" sort="Krushna, Nagampalli S A" uniqKey="Krushna N" first="Nagampalli S. A." last="Krushna">Nagampalli S. A. Krushna</name>
<affiliation><nlm:aff id="A1">Centre for Biotechnology, Anna University, Chennai 600025, India</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Babu, Subash" sort="Babu, Subash" uniqKey="Babu S" first="Subash" last="Babu">Subash Babu</name>
<affiliation><nlm:aff id="A2">NIH-TRC-ICER SAIC-Frederick Inc., National Cancer Institute at Frederick, Chetpet, Chennai, India</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Elango, S" sort="Elango, S" uniqKey="Elango S" first="S." last="Elango">S. Elango</name>
<affiliation><nlm:aff id="A3">Department of Public Health and Preventive Medicine, Government of Tamil Nadu, Chennai, India</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Manokaran, Guruswamy" sort="Manokaran, Guruswamy" uniqKey="Manokaran G" first="Guruswamy" last="Manokaran">Guruswamy Manokaran</name>
<affiliation><nlm:aff id="A4">Apollo Hospital, Greams Road, Chennai, India</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Narayanan, Rangarajan Badri" sort="Narayanan, Rangarajan Badri" uniqKey="Narayanan R" first="Rangarajan Badri" last="Narayanan">Rangarajan Badri Narayanan</name>
<affiliation><nlm:aff id="A1">Centre for Biotechnology, Anna University, Chennai 600025, India</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Microbes and infection / Institut Pasteur</title>
<idno type="ISSN">1286-4579</idno>
<idno type="eISSN">1769-714X</idno>
<imprint><date when="2011">2011</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P1"><italic>Wolbachia</italic>
, an endosymbiont present in filarial nematodes, have been implicated in a variety of roles, including the worm development and survival. Elucidation of the role of <italic>Wolbachia</italic>
in filarial nematode biology and pathogenesis has become the focus of many studies and its contribution to parasite survival or immune response is still unclear. Recombinant <italic>Wolbachia</italic>
HSP60 decreases T cell activation and lymphoproliferation in filarial infected people compared to endemic controls as observed by the assessment of T cell activation markers and cytokine responses in the peripheral blood mononuclear cells. Reduced T cell activation may be linked to T regulatory cell activity since it is associated with increased expression of CTLA4 and CD25 on CD4<sup>+</sup>
T cells in filarial infected group upon stimulation with recombinant <italic>Wolbachia</italic>
HSP60. In addition, elevated interleukin-10 and TGF-β cytokines corroborate the reduced CD4<sup>+</sup>
T cell activation and interferon-γ observed upon recombinant <italic>Wolbachia</italic>
HSP60 stimulation in filarial patients. Hence, these findings indicate that <italic>Wolbachia</italic>
HSP60 may also contribute to the immune modulation seen in filarial patients.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">100883508</journal-id>
<journal-id journal-id-type="pubmed-jr-id">21592</journal-id>
<journal-id journal-id-type="nlm-ta">Microbes Infect</journal-id>
<journal-id journal-id-type="iso-abbrev">Microbes Infect.</journal-id>
<journal-title-group><journal-title>Microbes and infection / Institut Pasteur</journal-title>
</journal-title-group>
<issn pub-type="ppub">1286-4579</issn>
<issn pub-type="epub">1769-714X</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">21827871</article-id>
<article-id pub-id-type="pmc">3515687</article-id>
<article-id pub-id-type="doi">10.1016/j.micinf.2011.07.004</article-id>
<article-id pub-id-type="manuscript">NIHMS423940</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Recombinant <italic>Wolbachia</italic>
heat shock protein 60 (HSP60) mediated immune responses in patients with lymphatic filariasis</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Shiny</surname>
<given-names>Chandanapurath</given-names>
</name>
<xref ref-type="aff" rid="A1">a</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Krushna</surname>
<given-names>Nagampalli S.A.</given-names>
</name>
<xref ref-type="aff" rid="A1">a</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Babu</surname>
<given-names>Subash</given-names>
</name>
<xref ref-type="aff" rid="A2">b</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Elango</surname>
<given-names>S.</given-names>
</name>
<xref ref-type="aff" rid="A3">c</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Manokaran</surname>
<given-names>Guruswamy</given-names>
</name>
<xref ref-type="aff" rid="A4">d</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Narayanan</surname>
<given-names>Rangarajan Badri</given-names>
</name>
<xref ref-type="aff" rid="A1">a</xref>
<xref rid="FN1" ref-type="author-notes">*</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>a</label>
Centre for Biotechnology, Anna University, Chennai 600025, India</aff>
<aff id="A2"><label>b</label>
NIH-TRC-ICER SAIC-Frederick Inc., National Cancer Institute at Frederick, Chetpet, Chennai, India</aff>
<aff id="A3"><label>c</label>
Department of Public Health and Preventive Medicine, Government of Tamil Nadu, Chennai, India</aff>
<aff id="A4"><label>d</label>
Apollo Hospital, Greams Road, Chennai, India</aff>
<author-notes><corresp id="FN1"><label>*</label>
Corresponding author. Tel.: +91 44 22350772; fax: +91 44 22350299. <email>rbn@annauniv.edu</email>
(R.B. Narayanan)</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>27</day>
<month>11</month>
<year>2012</year>
</pub-date>
<pub-date pub-type="epub"><day>23</day>
<month>7</month>
<year>2011</year>
</pub-date>
<pub-date pub-type="ppub"><month>12</month>
<year>2011</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>06</day>
<month>12</month>
<year>2012</year>
</pub-date>
<volume>13</volume>
<issue>14-15</issue>
<fpage>1221</fpage>
<lpage>1231</lpage>
<permissions><copyright-statement>© 2011 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.</copyright-statement>
<copyright-year>2011</copyright-year>
</permissions>
<abstract><p id="P1"><italic>Wolbachia</italic>
, an endosymbiont present in filarial nematodes, have been implicated in a variety of roles, including the worm development and survival. Elucidation of the role of <italic>Wolbachia</italic>
in filarial nematode biology and pathogenesis has become the focus of many studies and its contribution to parasite survival or immune response is still unclear. Recombinant <italic>Wolbachia</italic>
HSP60 decreases T cell activation and lymphoproliferation in filarial infected people compared to endemic controls as observed by the assessment of T cell activation markers and cytokine responses in the peripheral blood mononuclear cells. Reduced T cell activation may be linked to T regulatory cell activity since it is associated with increased expression of CTLA4 and CD25 on CD4<sup>+</sup>
T cells in filarial infected group upon stimulation with recombinant <italic>Wolbachia</italic>
HSP60. In addition, elevated interleukin-10 and TGF-β cytokines corroborate the reduced CD4<sup>+</sup>
T cell activation and interferon-γ observed upon recombinant <italic>Wolbachia</italic>
HSP60 stimulation in filarial patients. Hence, these findings indicate that <italic>Wolbachia</italic>
HSP60 may also contribute to the immune modulation seen in filarial patients.</p>
</abstract>
<kwd-group><kwd><italic>Wolbachia</italic>
</kwd>
<kwd>Immune modulation</kwd>
<kwd>Filaria</kwd>
<kwd><italic>Brugia malayi</italic>
</kwd>
<kwd>Cytokines</kwd>
<kwd>T cells</kwd>
</kwd-group>
<funding-group><award-group><funding-source country="United States">National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID</funding-source>
<award-id>Z99 AI999999 || AI</award-id>
</award-group>
</funding-group>
</article-meta>
</front>
</pmc>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Pmc/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003411 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd -nk 003411 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= LymphedemaV1 |flux= Pmc |étape= Corpus |type= RBID |clé= PMC:3515687 |texte= Recombinant Wolbachia heat shock protein 60 (HSP60) mediated immune responses in patients with lymphatic filariasis }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/RBID.i -Sk "pubmed:21827871" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd \ | NlmPubMed2Wicri -a LymphedemaV1
![]() | This area was generated with Dilib version V0.6.31. | ![]() |