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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Association of Obesity and Circulating Adipose Stromal Cells Among Breast Cancer Survivors</title><author><name sortKey="Ghosh, Sagar" sort="Ghosh, Sagar" uniqKey="Ghosh S" first="Sagar" last="Ghosh">Sagar Ghosh</name><affiliation><nlm:aff id="A1">Department of Molecular Medicine Institute of Biotechnology, University of Texas Health Science Center at San Antonio San Antonio, TX 78229 USA</nlm:aff></affiliation></author><author><name sortKey="Hughes, Daniel" sort="Hughes, Daniel" uniqKey="Hughes D" first="Daniel" last="Hughes">Daniel Hughes</name><affiliation><nlm:aff id="A2">Department of Epidemiology & Biostatistics Institute for Health Promotion Research, University of Texas Health Science Center at San Antonio San Antonio, TX 78229 USA</nlm:aff></affiliation></author><author><name sortKey="Parma, Dorothy Long" sort="Parma, Dorothy Long" uniqKey="Parma D" first="Dorothy Long" last="Parma">Dorothy Long Parma</name><affiliation><nlm:aff id="A2">Department of Epidemiology & Biostatistics Institute for Health Promotion Research, University of Texas Health Science Center at San Antonio San Antonio, TX 78229 USA</nlm:aff></affiliation></author><author><name sortKey="Ramirez, Amelie" sort="Ramirez, Amelie" uniqKey="Ramirez A" first="Amelie" last="Ramirez">Amelie Ramirez</name><affiliation><nlm:aff id="A2">Department of Epidemiology & Biostatistics Institute for Health Promotion Research, University of Texas Health Science Center at San Antonio San Antonio, TX 78229 USA</nlm:aff></affiliation></author><author><name sortKey="Li, Rong" sort="Li, Rong" uniqKey="Li R" first="Rong" last="Li">Rong Li</name><affiliation><nlm:aff id="A1">Department of Molecular Medicine Institute of Biotechnology, University of Texas Health Science Center at San Antonio San Antonio, TX 78229 USA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24458825</idno><idno type="pmc">4016178</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016178</idno><idno type="RBID">PMC:4016178</idno><idno type="doi">10.1007/s11033-014-3146-1</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">003393</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">003393</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Association of Obesity and Circulating Adipose Stromal Cells Among Breast Cancer Survivors</title><author><name sortKey="Ghosh, Sagar" sort="Ghosh, Sagar" uniqKey="Ghosh S" first="Sagar" last="Ghosh">Sagar Ghosh</name><affiliation><nlm:aff id="A1">Department of Molecular Medicine Institute of Biotechnology, University of Texas Health Science Center at San Antonio San Antonio, TX 78229 USA</nlm:aff></affiliation></author><author><name sortKey="Hughes, Daniel" sort="Hughes, Daniel" uniqKey="Hughes D" first="Daniel" last="Hughes">Daniel Hughes</name><affiliation><nlm:aff id="A2">Department of Epidemiology & Biostatistics Institute for Health Promotion Research, University of Texas Health Science Center at San Antonio San Antonio, TX 78229 USA</nlm:aff></affiliation></author><author><name sortKey="Parma, Dorothy Long" sort="Parma, Dorothy Long" uniqKey="Parma D" first="Dorothy Long" last="Parma">Dorothy Long Parma</name><affiliation><nlm:aff id="A2">Department of Epidemiology & Biostatistics Institute for Health Promotion Research, University of Texas Health Science Center at San Antonio San Antonio, TX 78229 USA</nlm:aff></affiliation></author><author><name sortKey="Ramirez, Amelie" sort="Ramirez, Amelie" uniqKey="Ramirez A" first="Amelie" last="Ramirez">Amelie Ramirez</name><affiliation><nlm:aff id="A2">Department of Epidemiology & Biostatistics Institute for Health Promotion Research, University of Texas Health Science Center at San Antonio San Antonio, TX 78229 USA</nlm:aff></affiliation></author><author><name sortKey="Li, Rong" sort="Li, Rong" uniqKey="Li R" first="Rong" last="Li">Rong Li</name><affiliation><nlm:aff id="A1">Department of Molecular Medicine Institute of Biotechnology, University of Texas Health Science Center at San Antonio San Antonio, TX 78229 USA</nlm:aff></affiliation></author></analytic><series><title level="j">Molecular biology reports</title><idno type="ISSN">0301-4851</idno><idno type="eISSN">1573-4978</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">A positive association of obesity with breast cancer incidence and mortality is well established. Recent reports indicate that adipose stromal cells (ASCs) play an important role in breast cancer development and progression by producing estrogens and tumor-promoting cytokines. Furthermore, circulating ASCs have been uniquely detected in obese individuals, which is likely due to increased tissue remodeling and cell mobilization. The number of circulating ASCs is even more prominent in obese patients with colon and prostate cancers, both of which are exacerbated by obesity. To determine whether a similar association exists for breast cancer, we collected blood samples from a cohort of breast cancer survivors and enumerated circulating ASCs by flow cytometry on the basis of the previously established ASC-associated immunophenotype (CD34<sup>+</sup>/CD31<sup>−</sup>/CD45<sup>−</sup>). We found significantly higher levels of circulating ASCs (<italic>p</italic> < 0.001) in breast cancer survivors with body mass index (BMI) ≥ 30 kg/m<sup>2</sup> than their non-obese counterparts (BMI < 30). We also compared circulating ASCs before and after exercise of only the obese subjects enrolled in a 6-month individualized exercise program, but found no statistically significant difference, likely due to limited number of subjects in the study. Our findings suggest that circulating ASCs can serve as a potential biomarker for future studies of the impacts of obesity and physical activity on breast cancer recurrence and survival.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0403234</journal-id><journal-id journal-id-type="pubmed-jr-id">5917</journal-id><journal-id journal-id-type="nlm-ta">Mol Biol Rep</journal-id><journal-id journal-id-type="iso-abbrev">Mol. Biol. Rep.</journal-id><journal-title-group><journal-title>Molecular biology reports</journal-title></journal-title-group><issn pub-type="ppub">0301-4851</issn><issn pub-type="epub">1573-4978</issn></journal-meta><article-meta><article-id pub-id-type="pmid">24458825</article-id><article-id pub-id-type="pmc">4016178</article-id><article-id pub-id-type="doi">10.1007/s11033-014-3146-1</article-id><article-id pub-id-type="manuscript">NIHMS559583</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Association of Obesity and Circulating Adipose Stromal Cells Among Breast Cancer Survivors</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Ghosh</surname><given-names>Sagar</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Hughes</surname><given-names>Daniel</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Parma</surname><given-names>Dorothy Long</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Ramirez</surname><given-names>Amelie</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Li</surname><given-names>Rong</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="corresp" rid="CR1">*</xref></contrib></contrib-group><aff id="A1"><label>1</label>Department of Molecular Medicine Institute of Biotechnology, University of Texas Health Science Center at San Antonio San Antonio, TX 78229 USA</aff><aff id="A2"><label>2</label>Department of Epidemiology & Biostatistics Institute for Health Promotion Research, University of Texas Health Science Center at San Antonio San Antonio, TX 78229 USA</aff><author-notes><corresp id="CR1"><label>*</label>Corresponding author Phone: 210-562-4152 Fax: 210-562-4161 <email>lir3@uthscsa.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>10</day><month>3</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>24</day><month>1</month><year>2014</year></pub-date><pub-date pub-type="ppub"><month>5</month><year>2014</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>5</month><year>2015</year></pub-date><volume>41</volume><issue>5</issue><fpage>2907</fpage><lpage>2916</lpage><pmc-comment>elocation-id from pubmed: 10.1007/s11033-014-3146-1</pmc-comment>
<abstract><p id="P1">A positive association of obesity with breast cancer incidence and mortality is well established. Recent reports indicate that adipose stromal cells (ASCs) play an important role in breast cancer development and progression by producing estrogens and tumor-promoting cytokines. Furthermore, circulating ASCs have been uniquely detected in obese individuals, which is likely due to increased tissue remodeling and cell mobilization. The number of circulating ASCs is even more prominent in obese patients with colon and prostate cancers, both of which are exacerbated by obesity. To determine whether a similar association exists for breast cancer, we collected blood samples from a cohort of breast cancer survivors and enumerated circulating ASCs by flow cytometry on the basis of the previously established ASC-associated immunophenotype (CD34<sup>+</sup>/CD31<sup>−</sup>/CD45<sup>−</sup>). We found significantly higher levels of circulating ASCs (<italic>p</italic> < 0.001) in breast cancer survivors with body mass index (BMI) ≥ 30 kg/m<sup>2</sup> than their non-obese counterparts (BMI < 30). We also compared circulating ASCs before and after exercise of only the obese subjects enrolled in a 6-month individualized exercise program, but found no statistically significant difference, likely due to limited number of subjects in the study. Our findings suggest that circulating ASCs can serve as a potential biomarker for future studies of the impacts of obesity and physical activity on breast cancer recurrence and survival.</p></abstract><kwd-group><kwd>circulating adipose stromal cells (ASC)</kwd><kwd>obesity</kwd><kwd>breast cancer</kwd><kwd>exercise</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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