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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Immune activation by life-shortening <italic>Wolbachia</italic> and reduced filarial competence in mosquitoes</title><author><name sortKey="Kambris, Zakaria" sort="Kambris, Zakaria" uniqKey="Kambris Z" first="Zakaria" last="Kambris">Zakaria Kambris</name></author><author><name sortKey="Cook, Peter E" sort="Cook, Peter E" uniqKey="Cook P" first="Peter E." last="Cook">Peter E. Cook</name></author><author><name sortKey="Phuc, Hoang K" sort="Phuc, Hoang K" uniqKey="Phuc H" first="Hoang K." last="Phuc">Hoang K. Phuc</name></author><author><name sortKey="Sinkins, Steven P" sort="Sinkins, Steven P" uniqKey="Sinkins S" first="Steven P." last="Sinkins">Steven P. Sinkins</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">19797660</idno><idno type="pmc">2867033</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2867033</idno><idno type="RBID">PMC:2867033</idno><idno type="doi">10.1126/science.1177531</idno><date when="2009">2009</date><idno type="wicri:Area/Pmc/Corpus">003394</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">003394</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Immune activation by life-shortening <italic>Wolbachia</italic> and reduced filarial competence in mosquitoes</title><author><name sortKey="Kambris, Zakaria" sort="Kambris, Zakaria" uniqKey="Kambris Z" first="Zakaria" last="Kambris">Zakaria Kambris</name></author><author><name sortKey="Cook, Peter E" sort="Cook, Peter E" uniqKey="Cook P" first="Peter E." last="Cook">Peter E. Cook</name></author><author><name sortKey="Phuc, Hoang K" sort="Phuc, Hoang K" uniqKey="Phuc H" first="Hoang K." last="Phuc">Hoang K. Phuc</name></author><author><name sortKey="Sinkins, Steven P" sort="Sinkins, Steven P" uniqKey="Sinkins S" first="Steven P." last="Sinkins">Steven P. Sinkins</name></author></analytic><series><title level="j">Science (New York, N.Y.)</title><idno type="ISSN">0036-8075</idno><idno type="eISSN">1095-9203</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1"><italic>Wolbachia</italic> strain <italic>w</italic>MelPop reduces longevity of its <italic>Drosophila melanogaster</italic> host and halves lifespan when introduced into the mosquito <italic>Aedes aegypti</italic>. We show that <italic>w</italic>MelPop induces upregulation of the mosquito innate immune system and that its presence inhibits the development of filarial nematodes in the mosquito. These data suggest that <italic>w</italic>MelPop could be used in the global effort to eliminate lymphatic filariasis, and possibly the control of other mosquito-borne parasites where immune preactivation inhibits their development. The cost of constitutive immune upregulation may contribute to the life-shortening phenotype.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
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<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0404511</journal-id><journal-id journal-id-type="pubmed-jr-id">7473</journal-id><journal-id journal-id-type="nlm-ta">Science</journal-id><journal-id journal-id-type="iso-abbrev">Science</journal-id><journal-title-group><journal-title>Science (New York, N.Y.)</journal-title></journal-title-group><issn pub-type="ppub">0036-8075</issn><issn pub-type="epub">1095-9203</issn></journal-meta><article-meta><article-id pub-id-type="pmid">19797660</article-id><article-id pub-id-type="pmc">2867033</article-id><article-id pub-id-type="doi">10.1126/science.1177531</article-id><article-id pub-id-type="manuscript">UKMS30392</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Immune activation by life-shortening <italic>Wolbachia</italic> and reduced filarial competence in mosquitoes</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Kambris</surname><given-names>Zakaria</given-names></name></contrib><contrib contrib-type="author"><name><surname>Cook</surname><given-names>Peter E.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Phuc</surname><given-names>Hoang K.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Sinkins</surname><given-names>Steven P.</given-names></name><xref ref-type="corresp" rid="CR1">*</xref></contrib><aff id="A1">Peter Medawar Building for Pathogen Research & Dept. Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK.</aff></contrib-group><author-notes><corresp id="CR1"><label>*</label>To whom correspondence should be addressed. <email>steven.sinkins@zoo.ox.ac.uk</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>4</day><month>5</month><year>2010</year></pub-date><pub-date pub-type="ppub"><day>2</day><month>10</month><year>2009</year></pub-date><pub-date pub-type="pmc-release"><day>11</day><month>5</month><year>2010</year></pub-date><volume>326</volume><issue>5949</issue><fpage>134</fpage><lpage>136</lpage><abstract><p id="P1"><italic>Wolbachia</italic> strain <italic>w</italic>MelPop reduces longevity of its <italic>Drosophila melanogaster</italic> host and halves lifespan when introduced into the mosquito <italic>Aedes aegypti</italic>. We show that <italic>w</italic>MelPop induces upregulation of the mosquito innate immune system and that its presence inhibits the development of filarial nematodes in the mosquito. These data suggest that <italic>w</italic>MelPop could be used in the global effort to eliminate lymphatic filariasis, and possibly the control of other mosquito-borne parasites where immune preactivation inhibits their development. The cost of constitutive immune upregulation may contribute to the life-shortening phenotype.</p></abstract><funding-group><award-group><funding-source country="United Kingdom">Wellcome Trust : </funding-source><award-id>079059 || WT</award-id></award-group></funding-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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