Links to Exploration step
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Immune activation by life-shortening <italic>Wolbachia</italic>
and reduced filarial competence in mosquitoes</title>
<author><name sortKey="Kambris, Zakaria" sort="Kambris, Zakaria" uniqKey="Kambris Z" first="Zakaria" last="Kambris">Zakaria Kambris</name>
</author>
<author><name sortKey="Cook, Peter E" sort="Cook, Peter E" uniqKey="Cook P" first="Peter E." last="Cook">Peter E. Cook</name>
</author>
<author><name sortKey="Phuc, Hoang K" sort="Phuc, Hoang K" uniqKey="Phuc H" first="Hoang K." last="Phuc">Hoang K. Phuc</name>
</author>
<author><name sortKey="Sinkins, Steven P" sort="Sinkins, Steven P" uniqKey="Sinkins S" first="Steven P." last="Sinkins">Steven P. Sinkins</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">19797660</idno>
<idno type="pmc">2867033</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2867033</idno>
<idno type="RBID">PMC:2867033</idno>
<idno type="doi">10.1126/science.1177531</idno>
<date when="2009">2009</date>
<idno type="wicri:Area/Pmc/Corpus">003394</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">003394</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Immune activation by life-shortening <italic>Wolbachia</italic>
and reduced filarial competence in mosquitoes</title>
<author><name sortKey="Kambris, Zakaria" sort="Kambris, Zakaria" uniqKey="Kambris Z" first="Zakaria" last="Kambris">Zakaria Kambris</name>
</author>
<author><name sortKey="Cook, Peter E" sort="Cook, Peter E" uniqKey="Cook P" first="Peter E." last="Cook">Peter E. Cook</name>
</author>
<author><name sortKey="Phuc, Hoang K" sort="Phuc, Hoang K" uniqKey="Phuc H" first="Hoang K." last="Phuc">Hoang K. Phuc</name>
</author>
<author><name sortKey="Sinkins, Steven P" sort="Sinkins, Steven P" uniqKey="Sinkins S" first="Steven P." last="Sinkins">Steven P. Sinkins</name>
</author>
</analytic>
<series><title level="j">Science (New York, N.Y.)</title>
<idno type="ISSN">0036-8075</idno>
<idno type="eISSN">1095-9203</idno>
<imprint><date when="2009">2009</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P1"><italic>Wolbachia</italic>
strain <italic>w</italic>
MelPop reduces longevity of its <italic>Drosophila melanogaster</italic>
host and halves lifespan when introduced into the mosquito <italic>Aedes aegypti</italic>
. We show that <italic>w</italic>
MelPop induces upregulation of the mosquito innate immune system and that its presence inhibits the development of filarial nematodes in the mosquito. These data suggest that <italic>w</italic>
MelPop could be used in the global effort to eliminate lymphatic filariasis, and possibly the control of other mosquito-borne parasites where immune preactivation inhibits their development. The cost of constitutive immune upregulation may contribute to the life-shortening phenotype.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0404511</journal-id>
<journal-id journal-id-type="pubmed-jr-id">7473</journal-id>
<journal-id journal-id-type="nlm-ta">Science</journal-id>
<journal-id journal-id-type="iso-abbrev">Science</journal-id>
<journal-title-group><journal-title>Science (New York, N.Y.)</journal-title>
</journal-title-group>
<issn pub-type="ppub">0036-8075</issn>
<issn pub-type="epub">1095-9203</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">19797660</article-id>
<article-id pub-id-type="pmc">2867033</article-id>
<article-id pub-id-type="doi">10.1126/science.1177531</article-id>
<article-id pub-id-type="manuscript">UKMS30392</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Immune activation by life-shortening <italic>Wolbachia</italic>
and reduced filarial competence in mosquitoes</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Kambris</surname>
<given-names>Zakaria</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Cook</surname>
<given-names>Peter E.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Phuc</surname>
<given-names>Hoang K.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Sinkins</surname>
<given-names>Steven P.</given-names>
</name>
<xref ref-type="corresp" rid="CR1">*</xref>
</contrib>
<aff id="A1">Peter Medawar Building for Pathogen Research & Dept. Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK.</aff>
</contrib-group>
<author-notes><corresp id="CR1"><label>*</label>
To whom correspondence should be addressed. <email>steven.sinkins@zoo.ox.ac.uk</email>
</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>4</day>
<month>5</month>
<year>2010</year>
</pub-date>
<pub-date pub-type="ppub"><day>2</day>
<month>10</month>
<year>2009</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>11</day>
<month>5</month>
<year>2010</year>
</pub-date>
<volume>326</volume>
<issue>5949</issue>
<fpage>134</fpage>
<lpage>136</lpage>
<abstract><p id="P1"><italic>Wolbachia</italic>
strain <italic>w</italic>
MelPop reduces longevity of its <italic>Drosophila melanogaster</italic>
host and halves lifespan when introduced into the mosquito <italic>Aedes aegypti</italic>
. We show that <italic>w</italic>
MelPop induces upregulation of the mosquito innate immune system and that its presence inhibits the development of filarial nematodes in the mosquito. These data suggest that <italic>w</italic>
MelPop could be used in the global effort to eliminate lymphatic filariasis, and possibly the control of other mosquito-borne parasites where immune preactivation inhibits their development. The cost of constitutive immune upregulation may contribute to the life-shortening phenotype.</p>
</abstract>
<funding-group><award-group><funding-source country="United Kingdom">Wellcome Trust : </funding-source>
<award-id>079059 || WT</award-id>
</award-group>
</funding-group>
</article-meta>
</front>
</pmc>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Pmc/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 0033940 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd -nk 0033940 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= LymphedemaV1 |flux= Pmc |étape= Corpus |type= RBID |clé= |texte= }}
![]() | This area was generated with Dilib version V0.6.31. | ![]() |