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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Elevated Levels of Plasma Angiogenic Factors Are Associated with Human Lymphatic Filarial Infections</title><author><name sortKey="Bennuru, Sasisekhar" sort="Bennuru, Sasisekhar" uniqKey="Bennuru S" first="Sasisekhar" last="Bennuru">Sasisekhar Bennuru</name></author><author><name sortKey="Maldarelli, Grace" sort="Maldarelli, Grace" uniqKey="Maldarelli G" first="Grace" last="Maldarelli">Grace Maldarelli</name></author><author><name sortKey="Kumaraswami, V" sort="Kumaraswami, V" uniqKey="Kumaraswami V" first="V." last="Kumaraswami">V. Kumaraswami</name></author><author><name sortKey="Klion, Amy D" sort="Klion, Amy D" uniqKey="Klion A" first="Amy D." last="Klion">Amy D. Klion</name></author><author><name sortKey="Nutman, Thomas B" sort="Nutman, Thomas B" uniqKey="Nutman T" first="Thomas B." last="Nutman">Thomas B. Nutman</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">20889885</idno><idno type="pmc">2946762</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2946762</idno><idno type="RBID">PMC:2946762</idno><idno type="doi">10.4269/ajtmh.2010.10-0039</idno><date when="2010">2010</date><idno type="wicri:Area/Pmc/Corpus">002C09</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002C09</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Elevated Levels of Plasma Angiogenic Factors Are Associated with Human Lymphatic Filarial Infections</title><author><name sortKey="Bennuru, Sasisekhar" sort="Bennuru, Sasisekhar" uniqKey="Bennuru S" first="Sasisekhar" last="Bennuru">Sasisekhar Bennuru</name></author><author><name sortKey="Maldarelli, Grace" sort="Maldarelli, Grace" uniqKey="Maldarelli G" first="Grace" last="Maldarelli">Grace Maldarelli</name></author><author><name sortKey="Kumaraswami, V" sort="Kumaraswami, V" uniqKey="Kumaraswami V" first="V." last="Kumaraswami">V. Kumaraswami</name></author><author><name sortKey="Klion, Amy D" sort="Klion, Amy D" uniqKey="Klion A" first="Amy D." last="Klion">Amy D. Klion</name></author><author><name sortKey="Nutman, Thomas B" sort="Nutman, Thomas B" uniqKey="Nutman T" first="Thomas B." last="Nutman">Thomas B. Nutman</name></author></analytic><series><title level="j">The American Journal of Tropical Medicine and Hygiene</title><idno type="ISSN">0002-9637</idno><idno type="eISSN">1476-1645</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Lymphatic dilatation, dysfunction, and lymphangiogenesis are hallmarks of patent lymphatic filariasis, observed even in those with subclinical microfilaremia, through processes associated, in part, by vascular endothelial growth factors (VEGFs). A panel of pro-angiogenic factors was measured in the plasma of subjects from filaria-endemic regions using multiplexed immunological assays. Compared with endemic normal control subjects, those with both subclinical microfilaremia, and those with longstanding lymphedema had significantly elevated levels of VEGF-A, VEGF-C, VEGF-D, and angiopoeitins (Ang-1/Ang-2), with only levels of basic fibroblast growth factor (bFGF) and placental growth factor (PlGF) being elevated only if lymphedema was evident. Furthermore, levels of these factors 1-year post-treatment with doxycycline were similar to pretreatment levels suggesting a minimal role, if any, for <italic>Wolbachia</italic>. Our data support the concept that filarial infection <italic>per se</italic> is associated with elevated levels of most of the known pro-angiogenic factors, with only a few being associated with the serious pathologic consequences associated with <italic>Wuchereria bancrofti</italic> infection.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Am J Trop Med Hyg</journal-id><journal-id journal-id-type="publisher-id">tpmd</journal-id><journal-title-group><journal-title>The American Journal of Tropical Medicine and Hygiene</journal-title></journal-title-group><issn pub-type="ppub">0002-9637</issn><issn pub-type="epub">1476-1645</issn><publisher><publisher-name>The American Society of Tropical Medicine and Hygiene</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">20889885</article-id><article-id pub-id-type="pmc">2946762</article-id><article-id pub-id-type="doi">10.4269/ajtmh.2010.10-0039</article-id><article-categories><subj-group subj-group-type="heading"><subject>Articles</subject></subj-group></article-categories><title-group><article-title>Elevated Levels of Plasma Angiogenic Factors Are Associated with Human Lymphatic Filarial Infections</article-title><alt-title alt-title-type="left-running-head">BENNURU AND OTHERS</alt-title><alt-title alt-title-type="right-running-head">LYMPHANGIOGENIC FACTORS IN LYMPHATIC FILARIASIS</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Bennuru</surname><given-names>Sasisekhar</given-names></name><xref ref-type="corresp" rid="COR1">*</xref></contrib><contrib contrib-type="author"><name><surname>Maldarelli</surname><given-names>Grace</given-names></name></contrib><contrib contrib-type="author"><name><surname>Kumaraswami</surname><given-names>V.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Klion</surname><given-names>Amy D.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Nutman</surname><given-names>Thomas B.</given-names></name></contrib></contrib-group><aff id="AFF1">Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; Tuberculosis Research Center, ICMR, Chennai, India</aff><author-notes><corresp id="COR1">*Address correspondence to Sasisekhar Bennuru, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 4 Center Drive, Bldg. 4, Rm B1-05, Bethesda, MD 20892. E-mail: <email>bennurus@niaid.nih.gov</email></corresp></author-notes><pub-date pub-type="ppub"><day>05</day><month>10</month><year>2010</year></pub-date><volume>83</volume><issue>4</issue><fpage>884</fpage><lpage>890</lpage><history><date date-type="received"><day>20</day><month>1</month><year>2010</year></date><date date-type="accepted"><day>08</day><month>6</month><year>2010</year></date></history><permissions><copyright-statement>©The American Society of Tropical Medicine and Hygiene</copyright-statement><copyright-year>2010</copyright-year></permissions><abstract><p>Lymphatic dilatation, dysfunction, and lymphangiogenesis are hallmarks of patent lymphatic filariasis, observed even in those with subclinical microfilaremia, through processes associated, in part, by vascular endothelial growth factors (VEGFs). A panel of pro-angiogenic factors was measured in the plasma of subjects from filaria-endemic regions using multiplexed immunological assays. Compared with endemic normal control subjects, those with both subclinical microfilaremia, and those with longstanding lymphedema had significantly elevated levels of VEGF-A, VEGF-C, VEGF-D, and angiopoeitins (Ang-1/Ang-2), with only levels of basic fibroblast growth factor (bFGF) and placental growth factor (PlGF) being elevated only if lymphedema was evident. Furthermore, levels of these factors 1-year post-treatment with doxycycline were similar to pretreatment levels suggesting a minimal role, if any, for <italic>Wolbachia</italic>. Our data support the concept that filarial infection <italic>per se</italic> is associated with elevated levels of most of the known pro-angiogenic factors, with only a few being associated with the serious pathologic consequences associated with <italic>Wuchereria bancrofti</italic> infection.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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