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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Association between Mannose-Binding Lectin Polymorphisms and <italic>Wuchereria bancrofti</italic> Infection in Two Communities in North-Eastern Tanzania</title><author><name sortKey="Meyrowitsch, Dan W" sort="Meyrowitsch, Dan W" uniqKey="Meyrowitsch D" first="Dan W." last="Meyrowitsch">Dan W. Meyrowitsch</name></author><author><name sortKey="Simonsen, Paul E" sort="Simonsen, Paul E" uniqKey="Simonsen P" first="Paul E." last="Simonsen">Paul E. Simonsen</name></author><author><name sortKey="Garred, Peter" sort="Garred, Peter" uniqKey="Garred P" first="Peter" last="Garred">Peter Garred</name></author><author><name sortKey="Dalgaard, Michael" sort="Dalgaard, Michael" uniqKey="Dalgaard M" first="Michael" last="Dalgaard">Michael Dalgaard</name></author><author><name sortKey="Magesa, Stephen M" sort="Magesa, Stephen M" uniqKey="Magesa S" first="Stephen M." last="Magesa">Stephen M. Magesa</name></author><author><name sortKey="Alifrangis, Michael" sort="Alifrangis, Michael" uniqKey="Alifrangis M" first="Michael" last="Alifrangis">Michael Alifrangis</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">20065005</idno><idno type="pmc">2803519</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2803519</idno><idno type="RBID">PMC:2803519</idno><idno type="doi">10.4269/ajtmh.2010.09-0342</idno><date when="2010">2010</date><idno type="wicri:Area/Pmc/Corpus">002C08</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002C08</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Association between Mannose-Binding Lectin Polymorphisms and <italic>Wuchereria bancrofti</italic> Infection in Two Communities in North-Eastern Tanzania</title><author><name sortKey="Meyrowitsch, Dan W" sort="Meyrowitsch, Dan W" uniqKey="Meyrowitsch D" first="Dan W." last="Meyrowitsch">Dan W. Meyrowitsch</name></author><author><name sortKey="Simonsen, Paul E" sort="Simonsen, Paul E" uniqKey="Simonsen P" first="Paul E." last="Simonsen">Paul E. Simonsen</name></author><author><name sortKey="Garred, Peter" sort="Garred, Peter" uniqKey="Garred P" first="Peter" last="Garred">Peter Garred</name></author><author><name sortKey="Dalgaard, Michael" sort="Dalgaard, Michael" uniqKey="Dalgaard M" first="Michael" last="Dalgaard">Michael Dalgaard</name></author><author><name sortKey="Magesa, Stephen M" sort="Magesa, Stephen M" uniqKey="Magesa S" first="Stephen M." last="Magesa">Stephen M. Magesa</name></author><author><name sortKey="Alifrangis, Michael" sort="Alifrangis, Michael" uniqKey="Alifrangis M" first="Michael" last="Alifrangis">Michael Alifrangis</name></author></analytic><series><title level="j">The American Journal of Tropical Medicine and Hygiene</title><idno type="ISSN">0002-9637</idno><idno type="eISSN">1476-1645</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The association between selected mannose-binding lectin (MBL) genotype polymorphisms and <italic>Wuchereria bancrofti</italic> infection status was assessed among individuals whose infection status had been monitored for three decades. Blood samples were collected in 2006 and examined for polymorphisms in the <italic>mbl-2</italic> gene and for <italic>W. bancrofti</italic>-specific circulating filarial antigen (CFA) status. Logistic regression analysis showed a significant association between MBL genotype and CFA status, with low-expression MBL genotype individuals being almost three times more likely to be CFA positive than high-expression MBL genotype individuals (odds ratio [OR] = 2.90). When individuals' filarial infection (microfilaria) status in 1975 was included in the analyses, the gain of new infections between the two examination points was almost 10 times higher among individuals with low than among those with high MBL expression genotype (OR = 9.51). The susceptibility to <italic>W. bancrofti</italic> infection thus appears to be significantly affected by the MBL expression genotype of the host.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Am J Trop Med Hyg</journal-id><journal-id journal-id-type="publisher-id">tpmd</journal-id><journal-title-group><journal-title>The American Journal of Tropical Medicine and Hygiene</journal-title></journal-title-group><issn pub-type="ppub">0002-9637</issn><issn pub-type="epub">1476-1645</issn><publisher><publisher-name>The American Society of Tropical Medicine and Hygiene</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">20065005</article-id><article-id pub-id-type="pmc">2803519</article-id><article-id pub-id-type="doi">10.4269/ajtmh.2010.09-0342</article-id><article-categories><subj-group subj-group-type="heading"><subject>Articles</subject></subj-group></article-categories><title-group><article-title>Association between Mannose-Binding Lectin Polymorphisms and <italic>Wuchereria bancrofti</italic> Infection in Two Communities in North-Eastern Tanzania</article-title><alt-title alt-title-type="left-running-head">MEYROWITSCH AND OTHERS</alt-title><alt-title alt-title-type="right-running-head">MBL POLYMORPHISMS AND <italic>W. BANCROFTI</italic> INFECTION</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Meyrowitsch</surname><given-names>Dan W.</given-names></name><xref ref-type="corresp" rid="COR1">*</xref></contrib><contrib contrib-type="author"><name><surname>Simonsen</surname><given-names>Paul E.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Garred</surname><given-names>Peter</given-names></name></contrib><contrib contrib-type="author"><name><surname>Dalgaard</surname><given-names>Michael</given-names></name></contrib><contrib contrib-type="author"><name><surname>Magesa</surname><given-names>Stephen M.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Alifrangis</surname><given-names>Michael</given-names></name></contrib></contrib-group><aff id="AFF1"><italic>Section of Health Services Research, Department of Public Health, University of Copenhagen, Denmark; DBL-Centre for Health Research and Development, Faculty of Life Sciences, University of Copenhagen, Denmark; Laboratory of Molecular Medicine, Department of Clinical Immunology-7631, Copenhagen University Hospital, Denmark; Centre for Medical Parasitology, Department of International Health, Immunology and Microbiology, University of Copenhagen, and the Department of Infectious Diseases, Copenhagen University Hospital, Denmark; National Institute for Medical Research, Amani Medical Research Centre, Muheza, Tanzania; Centre for Medical Parasitology, Department of International Health, Immunology and Microbiology, University of Copenhagen, and the Department of Infectious Diseases, Copenhagen University Hospital (Rigshospitalet), Denmark</italic></aff><author-notes><corresp id="COR1">*Address correspondence to Dan W. Meyrowitsch, Øster Farimagsgade 5, DK-1014 Copenhagen, Denmark. E-mail: <email>d.meyrowitsch@pubhealth.ku.dk</email></corresp></author-notes><pub-date pub-type="ppub"><month>1</month><year>2010</year></pub-date><volume>82</volume><issue>1</issue><fpage>115</fpage><lpage>120</lpage><history><date date-type="received"><day>19</day><month>6</month><year>2009</year></date><date date-type="accepted"><day>12</day><month>10</month><year>2009</year></date></history><permissions><copyright-statement>© The American Society of Tropical Medicine and Hygiene</copyright-statement><copyright-year>2010</copyright-year></permissions><abstract><p>The association between selected mannose-binding lectin (MBL) genotype polymorphisms and <italic>Wuchereria bancrofti</italic> infection status was assessed among individuals whose infection status had been monitored for three decades. Blood samples were collected in 2006 and examined for polymorphisms in the <italic>mbl-2</italic> gene and for <italic>W. bancrofti</italic>-specific circulating filarial antigen (CFA) status. Logistic regression analysis showed a significant association between MBL genotype and CFA status, with low-expression MBL genotype individuals being almost three times more likely to be CFA positive than high-expression MBL genotype individuals (odds ratio [OR] = 2.90). When individuals' filarial infection (microfilaria) status in 1975 was included in the analyses, the gain of new infections between the two examination points was almost 10 times higher among individuals with low than among those with high MBL expression genotype (OR = 9.51). The susceptibility to <italic>W. bancrofti</italic> infection thus appears to be significantly affected by the MBL expression genotype of the host.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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