High-Dose Selenium for the Mitigation of Radiation Injury: A Pilot Study in a Rat Model
Identifieur interne : 002784 ( Pmc/Corpus ); précédent : 002783; suivant : 002785High-Dose Selenium for the Mitigation of Radiation Injury: A Pilot Study in a Rat Model
Auteurs : Fritz Sieber ; Sarah A. Muir ; Eric P. Cohen ; Paula E. North ; Brian L. Fish ; Amy A. Irving ; Marylou M Der ; John E. MoulderSource :
- Radiation research [ 0033-7587 ] ; 2009.
Abstract
The purpose of this study was to evaluate in an animal model the safety and efficacy of dietary supplementation with high doses of selenium for the mitigation of the type of radiation injury that might be sustained during a nuclear accident or an act of radiological terrorism. Age-matched male rats were exposed to 10 Gy (single dose) of total-body irradiation (TBI) followed by a syngeneic bone marrow transplant, then randomized to standard drinking water or drinking water supplemented with sodium selenite or seleno-L-methionine. At 21 weeks after TBI, most rats on standard drinking water had severe renal failure with a mean blood urea nitrogen (BUN) level of 124 ± 29 mg/dl (geometric mean ± SE) whereas rats on selenium-supplemented drinking water (100 μg/day) had a mean BUN level of 67 ± 12 mg/dl. The mitigating effect of selenium was confirmed by histopathological analyses. None of the animals on high-dose selenium showed signs of selenium toxicity. Our results suggest that dietary supplementation with high-dose selenium may provide a safe, effective and practical way to mitigate radiation injury to kidneys.
Url:
DOI: 10.1667/0033-7587-171.3.368
PubMed: 19267564
PubMed Central: 2679178
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Cohen</name><affiliation><nlm:aff id="A2"> Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin 53226</nlm:aff></affiliation></author><author><name sortKey="North, Paula E" sort="North, Paula E" uniqKey="North P" first="Paula E." last="North">Paula E. North</name><affiliation><nlm:aff id="A3"> Department of Pathology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226</nlm:aff></affiliation></author><author><name sortKey="Fish, Brian L" sort="Fish, Brian L" uniqKey="Fish B" first="Brian L." last="Fish">Brian L. Fish</name><affiliation><nlm:aff id="A4"> Department of Radiation Oncology and the Center for Medical Countermeasures against Radiological Terrorism, Medical College of Wisconsin, Milwaukee, Wisconsin 53226</nlm:aff></affiliation></author><author><name sortKey="Irving, Amy A" sort="Irving, Amy A" uniqKey="Irving A" first="Amy A." last="Irving">Amy A. Irving</name><affiliation><nlm:aff id="A4"> Department of Radiation Oncology and the Center for Medical Countermeasures against Radiological Terrorism, Medical College of Wisconsin, Milwaukee, Wisconsin 53226</nlm:aff></affiliation></author><author><name sortKey="M Der, Marylou" sort="M Der, Marylou" uniqKey="M Der M" first="Marylou" last="M Der">Marylou M Der</name><affiliation><nlm:aff id="A4"> Department of Radiation Oncology and the Center for Medical Countermeasures against Radiological Terrorism, Medical College of Wisconsin, Milwaukee, Wisconsin 53226</nlm:aff></affiliation></author><author><name sortKey="Moulder, John E" sort="Moulder, John E" uniqKey="Moulder J" first="John E." last="Moulder">John E. Moulder</name><affiliation><nlm:aff id="A4"> Department of Radiation Oncology and the Center for Medical Countermeasures against Radiological Terrorism, Medical College of Wisconsin, Milwaukee, Wisconsin 53226</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">19267564</idno><idno type="pmc">2679178</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2679178</idno><idno type="RBID">PMC:2679178</idno><idno type="doi">10.1667/0033-7587-171.3.368</idno><date when="2009">2009</date><idno type="wicri:Area/Pmc/Corpus">002784</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002784</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">High-Dose Selenium for the Mitigation of Radiation Injury: A Pilot Study in a Rat Model</title><author><name sortKey="Sieber, Fritz" sort="Sieber, Fritz" uniqKey="Sieber F" first="Fritz" last="Sieber">Fritz Sieber</name><affiliation><nlm:aff id="A1"> Department of Pediatrics and Children’s Research Institute, Medical College of Wisconsin, Milwaukee, Wisconsin 53226</nlm:aff></affiliation></author><author><name sortKey="Muir, Sarah A" sort="Muir, Sarah A" uniqKey="Muir S" first="Sarah A." last="Muir">Sarah A. Muir</name><affiliation><nlm:aff id="A1"> Department of Pediatrics and Children’s Research Institute, Medical College of Wisconsin, Milwaukee, Wisconsin 53226</nlm:aff></affiliation></author><author><name sortKey="Cohen, Eric P" sort="Cohen, Eric P" uniqKey="Cohen E" first="Eric P." last="Cohen">Eric P. Cohen</name><affiliation><nlm:aff id="A2"> Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin 53226</nlm:aff></affiliation></author><author><name sortKey="North, Paula E" sort="North, Paula E" uniqKey="North P" first="Paula E." last="North">Paula E. North</name><affiliation><nlm:aff id="A3"> Department of Pathology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226</nlm:aff></affiliation></author><author><name sortKey="Fish, Brian L" sort="Fish, Brian L" uniqKey="Fish B" first="Brian L." last="Fish">Brian L. Fish</name><affiliation><nlm:aff id="A4"> Department of Radiation Oncology and the Center for Medical Countermeasures against Radiological Terrorism, Medical College of Wisconsin, Milwaukee, Wisconsin 53226</nlm:aff></affiliation></author><author><name sortKey="Irving, Amy A" sort="Irving, Amy A" uniqKey="Irving A" first="Amy A." last="Irving">Amy A. Irving</name><affiliation><nlm:aff id="A4"> Department of Radiation Oncology and the Center for Medical Countermeasures against Radiological Terrorism, Medical College of Wisconsin, Milwaukee, Wisconsin 53226</nlm:aff></affiliation></author><author><name sortKey="M Der, Marylou" sort="M Der, Marylou" uniqKey="M Der M" first="Marylou" last="M Der">Marylou M Der</name><affiliation><nlm:aff id="A4"> Department of Radiation Oncology and the Center for Medical Countermeasures against Radiological Terrorism, Medical College of Wisconsin, Milwaukee, Wisconsin 53226</nlm:aff></affiliation></author><author><name sortKey="Moulder, John E" sort="Moulder, John E" uniqKey="Moulder J" first="John E." last="Moulder">John E. Moulder</name><affiliation><nlm:aff id="A4"> Department of Radiation Oncology and the Center for Medical Countermeasures against Radiological Terrorism, Medical College of Wisconsin, Milwaukee, Wisconsin 53226</nlm:aff></affiliation></author></analytic><series><title level="j">Radiation research</title><idno type="ISSN">0033-7587</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">The purpose of this study was to evaluate in an animal model the safety and efficacy of dietary supplementation with high doses of selenium for the mitigation of the type of radiation injury that might be sustained during a nuclear accident or an act of radiological terrorism. Age-matched male rats were exposed to 10 Gy (single dose) of total-body irradiation (TBI) followed by a syngeneic bone marrow transplant, then randomized to standard drinking water or drinking water supplemented with sodium selenite or seleno-L-methionine. At 21 weeks after TBI, most rats on standard drinking water had severe renal failure with a mean blood urea nitrogen (BUN) level of 124 ± 29 mg/dl (geometric mean ± SE) whereas rats on selenium-supplemented drinking water (100 μg/day) had a mean BUN level of 67 ± 12 mg/dl. The mitigating effect of selenium was confirmed by histopathological analyses. None of the animals on high-dose selenium showed signs of selenium toxicity. Our results suggest that dietary supplementation with high-dose selenium may provide a safe, effective and practical way to mitigate radiation injury to kidneys.</p></div></front></TEI><pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0401245</journal-id><journal-id journal-id-type="pubmed-jr-id">6844</journal-id><journal-id journal-id-type="nlm-ta">Radiat Res</journal-id><journal-title>Radiation research</journal-title><issn pub-type="ppub">0033-7587</issn></journal-meta><article-meta><article-id pub-id-type="pmid">19267564</article-id><article-id pub-id-type="pmc">2679178</article-id><article-id pub-id-type="doi">10.1667/0033-7587-171.3.368</article-id><article-id pub-id-type="manuscript">NIHMS98560</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>High-Dose Selenium for the Mitigation of Radiation Injury: A Pilot Study in a Rat Model</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Sieber</surname><given-names>Fritz</given-names></name><xref rid="A1" ref-type="aff">a</xref><xref rid="FN1" ref-type="author-notes">1</xref></contrib><contrib contrib-type="author"><name><surname>Muir</surname><given-names>Sarah A.</given-names></name><xref rid="A1" ref-type="aff">a</xref></contrib><contrib contrib-type="author"><name><surname>Cohen</surname><given-names>Eric P.</given-names></name><xref rid="A2" ref-type="aff">b</xref></contrib><contrib contrib-type="author"><name><surname>North</surname><given-names>Paula E.</given-names></name><xref rid="A3" ref-type="aff">c</xref></contrib><contrib contrib-type="author"><name><surname>Fish</surname><given-names>Brian L.</given-names></name><xref rid="A4" ref-type="aff">d</xref></contrib><contrib contrib-type="author"><name><surname>Irving</surname><given-names>Amy A.</given-names></name><xref rid="A4" ref-type="aff">d</xref></contrib><contrib contrib-type="author"><name><surname>Mäder</surname><given-names>Marylou</given-names></name><xref rid="A4" ref-type="aff">d</xref></contrib><contrib contrib-type="author"><name><surname>Moulder</surname><given-names>John E.</given-names></name><xref rid="A4" ref-type="aff">d</xref></contrib></contrib-group><aff id="A1"><label>a</label> Department of Pediatrics and Children’s Research Institute, Medical College of Wisconsin, Milwaukee, Wisconsin 53226</aff><aff id="A2"><label>b</label> Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin 53226</aff><aff id="A3"><label>c</label> Department of Pathology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226</aff><aff id="A4"><label>d</label> Department of Radiation Oncology and the Center for Medical Countermeasures against Radiological Terrorism, Medical College of Wisconsin, Milwaukee, Wisconsin 53226</aff><author-notes><corresp id="FN1"><label>1</label>Address for correspondence: Department of Pediatrics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226; e-mail: <email>fsieber@mcw.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>16</day><month>3</month><year>2009</year></pub-date><pub-date pub-type="ppub"><month>3</month><year>2009</year></pub-date><pub-date pub-type="pmc-release"><day>1</day><month>3</month><year>2010</year></pub-date><volume>171</volume><issue>3</issue><fpage>368</fpage><lpage>373</lpage><abstract><p id="P1">The purpose of this study was to evaluate in an animal model the safety and efficacy of dietary supplementation with high doses of selenium for the mitigation of the type of radiation injury that might be sustained during a nuclear accident or an act of radiological terrorism. Age-matched male rats were exposed to 10 Gy (single dose) of total-body irradiation (TBI) followed by a syngeneic bone marrow transplant, then randomized to standard drinking water or drinking water supplemented with sodium selenite or seleno-L-methionine. At 21 weeks after TBI, most rats on standard drinking water had severe renal failure with a mean blood urea nitrogen (BUN) level of 124 ± 29 mg/dl (geometric mean ± SE) whereas rats on selenium-supplemented drinking water (100 μg/day) had a mean BUN level of 67 ± 12 mg/dl. The mitigating effect of selenium was confirmed by histopathological analyses. None of the animals on high-dose selenium showed signs of selenium toxicity. Our results suggest that dietary supplementation with high-dose selenium may provide a safe, effective and practical way to mitigate radiation injury to kidneys.</p></abstract><contract-num rid="AI1">U19 AI067734-049002</contract-num><contract-num rid="AI1">U19 AI067734-049001</contract-num><contract-num rid="AI1">U19 AI067734-040002</contract-num><contract-num rid="AI1">U19 AI067734-04</contract-num><contract-num rid="AI1">U19 AI067734-039002</contract-num><contract-num rid="AI1">U19 AI067734-039001</contract-num><contract-num rid="AI1">U19 AI067734-030002</contract-num><contract-num rid="AI1">U19 AI067734-03</contract-num><contract-num rid="AI1">U19 AI067734-029002</contract-num><contract-num rid="AI1">U19 AI067734-029001</contract-num><contract-num rid="AI1">U19 AI067734-020002</contract-num><contract-num rid="AI1">U19 AI067734-02</contract-num><contract-num rid="AI1">U19 AI067734-019002</contract-num><contract-num rid="AI1">U19 AI067734-019001</contract-num><contract-num rid="AI1">U19 AI067734-015718</contract-num><contract-num rid="AI1">U19 AI067734-010002</contract-num><contract-num rid="AI1">U19 AI067734-01</contract-num><contract-sponsor id="AI1">National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID</contract-sponsor></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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