In vivo carbon nanotube-enhanced non-invasive photoacoustic mapping of the sentinel lymph node
Identifieur interne : 002783 ( Pmc/Corpus ); précédent : 002782; suivant : 002784In vivo carbon nanotube-enhanced non-invasive photoacoustic mapping of the sentinel lymph node
Auteurs : Manojit Pramanik ; Kwang Hyun Song ; Magdalena Swierczewska ; Danielle Green ; Balaji Sitharaman ; Lihong V. WangSource :
- Physics in medicine and biology [ 0031-9155 ] ; 2009.
Abstract
Sentinel lymph node biopsy (SLNB), a less invasive alternative to axillary lymph node dissection (ALND), has become the standard of care for patients with clinically node-negative breast cancer. In SLNB, lymphatic mapping with radio-labeled sulfur colloid and/or blue dye helps identify the sentinel lymph node (SLN), which is most likely to contain metastatic breast cancer. Even though SLNB, using both methylene blue and radioactive tracers, has a high identification rate, it still relies on an invasive surgical procedure, with associated morbidity. In this study, we have demonstrated a non-invasive single-walled carbon nanotube (SWNT)-enhanced photoacoustic (PA) identification of SLN in a rat model. We have successfully imaged the SLN
Url:
DOI: 10.1088/0031-9155/54/11/001
PubMed: 19430111
PubMed Central: 2732197
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PMC:2732197Le document en format XML
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carbon nanotube-enhanced non-invasive photoacoustic mapping of the sentinel lymph node</title>
<author><name sortKey="Pramanik, Manojit" sort="Pramanik, Manojit" uniqKey="Pramanik M" first="Manojit" last="Pramanik">Manojit Pramanik</name>
<affiliation><nlm:aff id="A1"> Optical Imaging Laboratory, Department of Biomedical Engineering, Washington University in St. Louis, Missouri 63130, USA</nlm:aff>
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<author><name sortKey="Song, Kwang Hyun" sort="Song, Kwang Hyun" uniqKey="Song K" first="Kwang Hyun" last="Song">Kwang Hyun Song</name>
<affiliation><nlm:aff id="A1"> Optical Imaging Laboratory, Department of Biomedical Engineering, Washington University in St. Louis, Missouri 63130, USA</nlm:aff>
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<author><name sortKey="Swierczewska, Magdalena" sort="Swierczewska, Magdalena" uniqKey="Swierczewska M" first="Magdalena" last="Swierczewska">Magdalena Swierczewska</name>
<affiliation><nlm:aff id="A2"> Department of Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, New York 11794, USA</nlm:aff>
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<author><name sortKey="Green, Danielle" sort="Green, Danielle" uniqKey="Green D" first="Danielle" last="Green">Danielle Green</name>
<affiliation><nlm:aff id="A2"> Department of Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, New York 11794, USA</nlm:aff>
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<author><name sortKey="Sitharaman, Balaji" sort="Sitharaman, Balaji" uniqKey="Sitharaman B" first="Balaji" last="Sitharaman">Balaji Sitharaman</name>
<affiliation><nlm:aff id="A2"> Department of Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, New York 11794, USA</nlm:aff>
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<author><name sortKey="Wang, Lihong V" sort="Wang, Lihong V" uniqKey="Wang L" first="Lihong V." last="Wang">Lihong V. Wang</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main"><italic>In vivo</italic>
carbon nanotube-enhanced non-invasive photoacoustic mapping of the sentinel lymph node</title>
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<author><name sortKey="Swierczewska, Magdalena" sort="Swierczewska, Magdalena" uniqKey="Swierczewska M" first="Magdalena" last="Swierczewska">Magdalena Swierczewska</name>
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<author><name sortKey="Wang, Lihong V" sort="Wang, Lihong V" uniqKey="Wang L" first="Lihong V." last="Wang">Lihong V. Wang</name>
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<series><title level="j">Physics in medicine and biology</title>
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<front><div type="abstract" xml:lang="en"><p id="P1">Sentinel lymph node biopsy (SLNB), a less invasive alternative to axillary lymph node dissection (ALND), has become the standard of care for patients with clinically node-negative breast cancer. In SLNB, lymphatic mapping with radio-labeled sulfur colloid and/or blue dye helps identify the sentinel lymph node (SLN), which is most likely to contain metastatic breast cancer. Even though SLNB, using both methylene blue and radioactive tracers, has a high identification rate, it still relies on an invasive surgical procedure, with associated morbidity. In this study, we have demonstrated a non-invasive single-walled carbon nanotube (SWNT)-enhanced photoacoustic (PA) identification of SLN in a rat model. We have successfully imaged the SLN <italic>in vivo</italic>
by PA imaging (793 nm laser source, 5 MHz ultrasonic detector) with high contrast-to-noise ratio (= 89) and good resolution (~500 μm). The SWNTs also show a wideband optical absorption, generating PA signals over an excitation wavelength range of 740–820 nm. Thus, by varying the incident light wavelength to the near infrared region, where biological tissues (hemoglobin, tissue pigments, lipids, and water) show low light absorption, the imaging depth is maximized. In the future, functionalization of the SWNTs with targeting groups should allow the molecular imaging of breast cancer.</p>
</div>
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<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0401220</journal-id>
<journal-id journal-id-type="pubmed-jr-id">6459</journal-id>
<journal-id journal-id-type="nlm-ta">Phys Med Biol</journal-id>
<journal-title>Physics in medicine and biology</journal-title>
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<article-id pub-id-type="manuscript">NIHMS119544</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
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<title-group><article-title><italic>In vivo</italic>
carbon nanotube-enhanced non-invasive photoacoustic mapping of the sentinel lymph node</article-title>
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<contrib-group><contrib contrib-type="author"><name><surname>Pramanik</surname>
<given-names>Manojit</given-names>
</name>
<xref rid="A1" ref-type="aff">1</xref>
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<contrib contrib-type="author"><name><surname>Song</surname>
<given-names>Kwang Hyun</given-names>
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<xref rid="A1" ref-type="aff">1</xref>
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<contrib contrib-type="author"><name><surname>Swierczewska</surname>
<given-names>Magdalena</given-names>
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<contrib contrib-type="author"><name><surname>Green</surname>
<given-names>Danielle</given-names>
</name>
<xref rid="A2" ref-type="aff">2</xref>
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<contrib contrib-type="author"><name><surname>Sitharaman</surname>
<given-names>Balaji</given-names>
</name>
<xref rid="A2" ref-type="aff">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wang</surname>
<given-names>Lihong V.</given-names>
</name>
<xref rid="A1" ref-type="aff">1</xref>
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<aff id="A1"><label>1</label>
Optical Imaging Laboratory, Department of Biomedical Engineering, Washington University in St. Louis, Missouri 63130, USA</aff>
<aff id="A2"><label>2</label>
Department of Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, New York 11794, USA</aff>
<author-notes><corresp id="FN1">E-mail: <email>balaji.sitharaman@stonybrook.edu</email>
(CNT), <email>lhwang@biomed.wustl.edu</email>
(PA)</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>14</day>
<month>7</month>
<year>2009</year>
</pub-date>
<pub-date pub-type="epub"><day>8</day>
<month>5</month>
<year>2009</year>
</pub-date>
<pub-date pub-type="ppub"><day>7</day>
<month>6</month>
<year>2009</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>26</day>
<month>8</month>
<year>2009</year>
</pub-date>
<volume>54</volume>
<issue>11</issue>
<fpage>3291</fpage>
<lpage>3301</lpage>
<abstract><p id="P1">Sentinel lymph node biopsy (SLNB), a less invasive alternative to axillary lymph node dissection (ALND), has become the standard of care for patients with clinically node-negative breast cancer. In SLNB, lymphatic mapping with radio-labeled sulfur colloid and/or blue dye helps identify the sentinel lymph node (SLN), which is most likely to contain metastatic breast cancer. Even though SLNB, using both methylene blue and radioactive tracers, has a high identification rate, it still relies on an invasive surgical procedure, with associated morbidity. In this study, we have demonstrated a non-invasive single-walled carbon nanotube (SWNT)-enhanced photoacoustic (PA) identification of SLN in a rat model. We have successfully imaged the SLN <italic>in vivo</italic>
by PA imaging (793 nm laser source, 5 MHz ultrasonic detector) with high contrast-to-noise ratio (= 89) and good resolution (~500 μm). The SWNTs also show a wideband optical absorption, generating PA signals over an excitation wavelength range of 740–820 nm. Thus, by varying the incident light wavelength to the near infrared region, where biological tissues (hemoglobin, tissue pigments, lipids, and water) show low light absorption, the imaging depth is maximized. In the future, functionalization of the SWNTs with targeting groups should allow the molecular imaging of breast cancer.</p>
</abstract>
<contract-num rid="CA1">U54 CA136398-01</contract-num>
<contract-num rid="NS1">R01 NS046214-06</contract-num>
<contract-num rid="EB1">R01 EB008085-01A1</contract-num>
<contract-num rid="EB1">R01 EB000712-05</contract-num>
<contract-sponsor id="CA1">National Cancer Institute : NCI</contract-sponsor>
<contract-sponsor id="NS1">National Institute of Neurological Disorders and Stroke : NINDS</contract-sponsor>
<contract-sponsor id="EB1">National Institute of Biomedical Imaging and Bioengineering : NIBIB</contract-sponsor>
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