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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Neostatin-7 Regulates bFGF-induced Corneal Lymphangiogenesis</title><author><name sortKey="Kojima, Takashi" sort="Kojima, Takashi" uniqKey="Kojima T" first="Takashi" last="Kojima">Takashi Kojima</name></author><author><name sortKey="Azar, Dimitri T" sort="Azar, Dimitri T" uniqKey="Azar D" first="Dimitri T." last="Azar">Dimitri T. Azar</name></author><author><name sortKey="Chang, Jin Hong" sort="Chang, Jin Hong" uniqKey="Chang J" first="Jin-Hong" last="Chang">Jin-Hong Chang</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">18570894</idno><idno type="pmc">2579793</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2579793</idno><idno type="RBID">PMC:2579793</idno><idno type="doi">10.1016/j.febslet.2008.06.014</idno><date when="2008">2008</date><idno type="wicri:Area/Pmc/Corpus">002742</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002742</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Neostatin-7 Regulates bFGF-induced Corneal Lymphangiogenesis</title><author><name sortKey="Kojima, Takashi" sort="Kojima, Takashi" uniqKey="Kojima T" first="Takashi" last="Kojima">Takashi Kojima</name></author><author><name sortKey="Azar, Dimitri T" sort="Azar, Dimitri T" uniqKey="Azar D" first="Dimitri T." last="Azar">Dimitri T. Azar</name></author><author><name sortKey="Chang, Jin Hong" sort="Chang, Jin Hong" uniqKey="Chang J" first="Jin-Hong" last="Chang">Jin-Hong Chang</name></author></analytic><series><title level="j">FEBS letters</title><idno type="ISSN">0014-5793</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Neostatin-7, with an anti-angiogenic potential, is generated from the proteolytic action of matrix metalloproteinase-7 on collagen XVIII. We previously reported that neostatin-7 inhibited angiogenesis <italic>in vitro</italic> and <italic>in vivo</italic>. Here we demonstrate that neostatin-7/collagen XVIII may possess anti-lymphangiogenic activities by: 1) corneal micropellet implantation of neostatin-7 reduced bFGF-induced corneal lymphangiogenesis; 2) neostatin-7 bound to VEGF receptor-3 <italic>in vitro</italic>; and 3) enhanced corneal lymphangiogenesis and VEGF-C expression in collagen XVIII knockout mice in a corneal wounding model. Understanding the mechanism of neostatin-7/collagen XVIII on corneal lymphangiogenesis may provide therapeutic interventions to treat lymphangiogenesis-related disorders, such as lymphedema, transplantation rejection and cancers.</p></div></front></TEI><pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0155157</journal-id><journal-id journal-id-type="pubmed-jr-id">3696</journal-id><journal-id journal-id-type="nlm-ta">FEBS Lett</journal-id><journal-title>FEBS letters</journal-title><issn pub-type="ppub">0014-5793</issn></journal-meta><article-meta><article-id pub-id-type="pmid">18570894</article-id><article-id pub-id-type="pmc">2579793</article-id><article-id pub-id-type="manuscript">NIHMS59801</article-id><article-id pub-id-type="doi">10.1016/j.febslet.2008.06.014</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Neostatin-7 Regulates bFGF-induced Corneal Lymphangiogenesis</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Kojima</surname><given-names>Takashi</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Azar</surname><given-names>Dimitri T.</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Chang</surname><given-names>Jin-Hong</given-names></name><degrees>PhD</degrees><xref ref-type="corresp" rid="cor1">*</xref></contrib><aff id="A1">From the Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, USA</aff></contrib-group><author-notes><corresp id="cor1"><label>*</label>Corresponding author: Jin-Hong Chang, Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, 1855 W. Taylor Street, Chicago, IL 60612. Phone: 312-413-5590; Fax: 312-996-7770; E-mail: <email>changr@uic.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>29</day><month>7</month><year>2008</year></pub-date><pub-date pub-type="epub"><day>18</day><month>6</month><year>2008</year></pub-date><pub-date pub-type="ppub"><day>23</day><month>7</month><year>2008</year></pub-date><pub-date pub-type="pmc-release"><day>23</day><month>7</month><year>2009</year></pub-date><volume>582</volume><issue>17</issue><fpage>2515</fpage><lpage>2520</lpage><abstract><p id="P1">Neostatin-7, with an anti-angiogenic potential, is generated from the proteolytic action of matrix metalloproteinase-7 on collagen XVIII. We previously reported that neostatin-7 inhibited angiogenesis <italic>in vitro</italic> and <italic>in vivo</italic>. Here we demonstrate that neostatin-7/collagen XVIII may possess anti-lymphangiogenic activities by: 1) corneal micropellet implantation of neostatin-7 reduced bFGF-induced corneal lymphangiogenesis; 2) neostatin-7 bound to VEGF receptor-3 <italic>in vitro</italic>; and 3) enhanced corneal lymphangiogenesis and VEGF-C expression in collagen XVIII knockout mice in a corneal wounding model. Understanding the mechanism of neostatin-7/collagen XVIII on corneal lymphangiogenesis may provide therapeutic interventions to treat lymphangiogenesis-related disorders, such as lymphedema, transplantation rejection and cancers.</p></abstract><contract-num rid="EY1">R01 EY014048-05</contract-num><contract-num rid="EY1">R01 EY014048-04</contract-num><contract-num rid="EY1">R01 EY014048-03</contract-num><contract-num rid="EY1">R01 EY014048-02</contract-num><contract-num rid="EY1">R01 EY010101-15</contract-num><contract-num rid="EY1">R01 EY010101-14</contract-num><contract-num rid="EY1">P30 EY001792-30</contract-num><contract-sponsor id="EY1">National Eye Institute : NEI</contract-sponsor></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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