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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">CRSBP-1/LYVE-1-null Mice Exhibit Identifiable Morphological and Functional Alterations of Lymphatic Capillary Vessels</title><author><name sortKey="Huang, Shuan S" sort="Huang, Shuan S" uniqKey="Huang S" first="Shuan S." last="Huang">Shuan S. Huang</name><affiliation><nlm:aff id="A1">Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St. Louis, MO</nlm:aff></affiliation></author><author><name sortKey="Liu, I Hua" sort="Liu, I Hua" uniqKey="Liu I" first="I-Hua" last="Liu">I-Hua Liu</name><affiliation><nlm:aff id="A1">Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St. Louis, MO</nlm:aff></affiliation></author><author><name sortKey="Smith, Tracy" sort="Smith, Tracy" uniqKey="Smith T" first="Tracy" last="Smith">Tracy Smith</name><affiliation><nlm:aff id="A2">Department of Comparative medicine, Saint Louis University School of Medicine, St. Louis, MO</nlm:aff></affiliation></author><author><name sortKey="Shah, Maulik R" sort="Shah, Maulik R" uniqKey="Shah M" first="Maulik R." last="Shah">Maulik R. Shah</name><affiliation><nlm:aff id="A3">Department of Pediatrics, Saint Louis University School of Medicine, St. Louis, MO</nlm:aff></affiliation></author><author><name sortKey="Johnson, Frank E" sort="Johnson, Frank E" uniqKey="Johnson F" first="Frank E." last="Johnson">Frank E. Johnson</name><affiliation><nlm:aff id="A4">Department of Surgery, Saint Louis University School of Medicine, St. Louis, MO</nlm:aff></affiliation></author><author><name sortKey="Huang, Jung S" sort="Huang, Jung S" uniqKey="Huang J" first="Jung S." last="Huang">Jung S. Huang</name><affiliation><nlm:aff id="A1">Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St. Louis, MO</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">17070806</idno><idno type="pmc">3125019</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3125019</idno><idno type="RBID">PMC:3125019</idno><idno type="doi">10.1016/j.febslet.2006.10.028</idno><date when="2006">2006</date><idno type="wicri:Area/Pmc/Corpus">002743</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002743</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">CRSBP-1/LYVE-1-null Mice Exhibit Identifiable Morphological and Functional Alterations of Lymphatic Capillary Vessels</title><author><name sortKey="Huang, Shuan S" sort="Huang, Shuan S" uniqKey="Huang S" first="Shuan S." last="Huang">Shuan S. Huang</name><affiliation><nlm:aff id="A1">Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St. Louis, MO</nlm:aff></affiliation></author><author><name sortKey="Liu, I Hua" sort="Liu, I Hua" uniqKey="Liu I" first="I-Hua" last="Liu">I-Hua Liu</name><affiliation><nlm:aff id="A1">Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St. Louis, MO</nlm:aff></affiliation></author><author><name sortKey="Smith, Tracy" sort="Smith, Tracy" uniqKey="Smith T" first="Tracy" last="Smith">Tracy Smith</name><affiliation><nlm:aff id="A2">Department of Comparative medicine, Saint Louis University School of Medicine, St. Louis, MO</nlm:aff></affiliation></author><author><name sortKey="Shah, Maulik R" sort="Shah, Maulik R" uniqKey="Shah M" first="Maulik R." last="Shah">Maulik R. Shah</name><affiliation><nlm:aff id="A3">Department of Pediatrics, Saint Louis University School of Medicine, St. Louis, MO</nlm:aff></affiliation></author><author><name sortKey="Johnson, Frank E" sort="Johnson, Frank E" uniqKey="Johnson F" first="Frank E." last="Johnson">Frank E. Johnson</name><affiliation><nlm:aff id="A4">Department of Surgery, Saint Louis University School of Medicine, St. Louis, MO</nlm:aff></affiliation></author><author><name sortKey="Huang, Jung S" sort="Huang, Jung S" uniqKey="Huang J" first="Jung S." last="Huang">Jung S. Huang</name><affiliation><nlm:aff id="A1">Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St. Louis, MO</nlm:aff></affiliation></author></analytic><series><title level="j">FEBS letters</title><idno type="ISSN">0014-5793</idno><idno type="eISSN">1873-3468</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">CRSBP-1, a membrane glycoprotein, can mediate cell-surface retention of secreted growth factors containing CRS motifs such as PDGF-BB. CRSBP-1 has recently been found to be identical to LYVE-1, a specific marker for lymphatic capillary endothelial cells. The <italic>in vivo</italic> role of CRSBP-1/LYVE-1 is unknown. CRSBP-1-null mice are overtly normal and fertile but exhibit identifiable morphological and functional alterations of lymphatic capillary vessels in certain tissues, marked by the constitutively increased interstitial-lymphatic flow and lack of typical irregularly-shaped lumens. The CRSBP-1 ligands PDGF-BB and HA enhance interstitial-lymphatic flow in wild-type mice but not in CRSBP-1-null animals.</p></div></front></TEI><pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0155157</journal-id><journal-id journal-id-type="pubmed-jr-id">3696</journal-id><journal-id journal-id-type="nlm-ta">FEBS Lett</journal-id><journal-title>FEBS letters</journal-title><issn pub-type="ppub">0014-5793</issn><issn pub-type="epub">1873-3468</issn></journal-meta><article-meta><article-id pub-id-type="pmid">17070806</article-id><article-id pub-id-type="pmc">3125019</article-id><article-id pub-id-type="doi">10.1016/j.febslet.2006.10.028</article-id><article-id pub-id-type="manuscript">NIHMS13790</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>CRSBP-1/LYVE-1-null Mice Exhibit Identifiable Morphological and Functional Alterations of Lymphatic Capillary Vessels</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Huang</surname><given-names>Shuan S.</given-names></name><xref ref-type="corresp" rid="cor1">*</xref><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Liu</surname><given-names>I-Hua</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Smith</surname><given-names>Tracy</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Shah</surname><given-names>Maulik R.</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Johnson</surname><given-names>Frank E.</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Huang</surname><given-names>Jung S.</given-names></name><xref ref-type="corresp" rid="cor1">*</xref><xref ref-type="aff" rid="A1">1</xref></contrib></contrib-group><aff id="A1"><label>1</label>Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St. Louis, MO</aff><aff id="A2"><label>2</label>Department of Comparative medicine, Saint Louis University School of Medicine, St. Louis, MO</aff><aff id="A3"><label>3</label>Department of Pediatrics, Saint Louis University School of Medicine, St. Louis, MO</aff><aff id="A4"><label>4</label>Department of Surgery, Saint Louis University School of Medicine, St. Louis, MO</aff><author-notes><corresp id="cor1"><label>*</label>To whom correspondence should be addressed: Jung San Huang, Ph.D., Professor, Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, 1402 South Grand Boulevard, St. Louis, MO 63104, Phone: (314) 977-9250, Fax: (314) 977-9205, <email>huangjs@slu.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>19</day><month>8</month><year>2010</year></pub-date><pub-date pub-type="epub"><day>20</day><month>10</month><year>2006</year></pub-date><pub-date pub-type="ppub"><day>13</day><month>11</month><year>2006</year></pub-date><pub-date pub-type="pmc-release"><day>28</day><month>6</month><year>2011</year></pub-date><volume>580</volume><issue>26</issue><fpage>6259</fpage><lpage>6268</lpage><permissions><copyright-statement>© 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.</copyright-statement><copyright-year>2006</copyright-year></permissions><abstract><p id="P1">CRSBP-1, a membrane glycoprotein, can mediate cell-surface retention of secreted growth factors containing CRS motifs such as PDGF-BB. CRSBP-1 has recently been found to be identical to LYVE-1, a specific marker for lymphatic capillary endothelial cells. The <italic>in vivo</italic> role of CRSBP-1/LYVE-1 is unknown. CRSBP-1-null mice are overtly normal and fertile but exhibit identifiable morphological and functional alterations of lymphatic capillary vessels in certain tissues, marked by the constitutively increased interstitial-lymphatic flow and lack of typical irregularly-shaped lumens. The CRSBP-1 ligands PDGF-BB and HA enhance interstitial-lymphatic flow in wild-type mice but not in CRSBP-1-null animals.</p></abstract><kwd-group><kwd>CRSBP-1</kwd><kwd>LYVE-1</kwd><kwd>CRSBP-1/LYVE-1 null mice</kwd><kwd>PDGF</kwd><kwd>PDGF-BB</kwd><kwd>HA</kwd><kwd>distended lumens</kwd><kwd>interstitial-lymphatic flow</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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