Abstract 136: Short Duration 9-cis Retinoid Acid Therapy is Sufficient to Improve Functional Lymphatic Drainage in Post-Surgical Lymphedema
Identifieur interne : 001E13 ( Pmc/Corpus ); précédent : 001E12; suivant : 001E14Abstract 136: Short Duration 9-cis Retinoid Acid Therapy is Sufficient to Improve Functional Lymphatic Drainage in Post-Surgical Lymphedema
Auteurs : Gene K. Lee ; David P. Perrault ; Antoun Bouz ; Austin J. Pourmoussa ; Daniel Gardner ; Maxwell Johnson ; Sun Young Park ; Athanasios Bramos ; Eun Kyung Park ; Young Jin N. Seong ; Sunju Lee ; Lia E. Jung ; Dongwon Choi ; Young-Kwon Hong ; Alex K. WongSource :
- Plastic and Reconstructive Surgery Global Open [ 2169-7574 ] ; 2017.
Url:
DOI: 10.1097/01.GOX.0000516655.76706.86
PubMed: NONE
PubMed Central: 5417988
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Abstract 136: Short Duration 9-cis Retinoid Acid Therapy is Sufficient to Improve Functional Lymphatic Drainage in Post-Surgical Lymphedema</title><author><name sortKey="Lee, Gene K" sort="Lee, Gene K" uniqKey="Lee G" first="Gene K." last="Lee">Gene K. Lee</name></author><author><name sortKey="Perrault, David P" sort="Perrault, David P" uniqKey="Perrault D" first="David P." last="Perrault">David P. Perrault</name></author><author><name sortKey="Bouz, Antoun" sort="Bouz, Antoun" uniqKey="Bouz A" first="Antoun" last="Bouz">Antoun Bouz</name></author><author><name sortKey="Pourmoussa, Austin J" sort="Pourmoussa, Austin J" uniqKey="Pourmoussa A" first="Austin J." last="Pourmoussa">Austin J. Pourmoussa</name></author><author><name sortKey="Gardner, Daniel" sort="Gardner, Daniel" uniqKey="Gardner D" first="Daniel" last="Gardner">Daniel Gardner</name></author><author><name sortKey="Johnson, Maxwell" sort="Johnson, Maxwell" uniqKey="Johnson M" first="Maxwell" last="Johnson">Maxwell Johnson</name></author><author><name sortKey="Young Park, Sun" sort="Young Park, Sun" uniqKey="Young Park S" first="Sun" last="Young Park">Sun Young Park</name></author><author><name sortKey="Bramos, Athanasios" sort="Bramos, Athanasios" uniqKey="Bramos A" first="Athanasios" last="Bramos">Athanasios Bramos</name></author><author><name sortKey="Kyung Park, Eun" sort="Kyung Park, Eun" uniqKey="Kyung Park E" first="Eun" last="Kyung Park">Eun Kyung Park</name></author><author><name sortKey="Seong, Young Jin N" sort="Seong, Young Jin N" uniqKey="Seong Y" first="Young Jin N." last="Seong">Young Jin N. Seong</name></author><author><name sortKey="Lee, Sunju" sort="Lee, Sunju" uniqKey="Lee S" first="Sunju" last="Lee">Sunju Lee</name></author><author><name sortKey="Jung, Lia E" sort="Jung, Lia E" uniqKey="Jung L" first="Lia E." last="Jung">Lia E. Jung</name></author><author><name sortKey="Choi, Dongwon" sort="Choi, Dongwon" uniqKey="Choi D" first="Dongwon" last="Choi">Dongwon Choi</name></author><author><name sortKey="Hong, Young Kwon" sort="Hong, Young Kwon" uniqKey="Hong Y" first="Young-Kwon" last="Hong">Young-Kwon Hong</name></author><author><name sortKey="Wong, Alex K" sort="Wong, Alex K" uniqKey="Wong A" first="Alex K." last="Wong">Alex K. Wong</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmc">5417988</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5417988</idno><idno type="RBID">PMC:5417988</idno><idno type="doi">10.1097/01.GOX.0000516655.76706.86</idno><idno type="pmid">NONE</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">001E13</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001E13</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Abstract 136: Short Duration 9-cis Retinoid Acid Therapy is Sufficient to Improve Functional Lymphatic Drainage in Post-Surgical Lymphedema</title><author><name sortKey="Lee, Gene K" sort="Lee, Gene K" uniqKey="Lee G" first="Gene K." last="Lee">Gene K. Lee</name></author><author><name sortKey="Perrault, David P" sort="Perrault, David P" uniqKey="Perrault D" first="David P." last="Perrault">David P. Perrault</name></author><author><name sortKey="Bouz, Antoun" sort="Bouz, Antoun" uniqKey="Bouz A" first="Antoun" last="Bouz">Antoun Bouz</name></author><author><name sortKey="Pourmoussa, Austin J" sort="Pourmoussa, Austin J" uniqKey="Pourmoussa A" first="Austin J." last="Pourmoussa">Austin J. Pourmoussa</name></author><author><name sortKey="Gardner, Daniel" sort="Gardner, Daniel" uniqKey="Gardner D" first="Daniel" last="Gardner">Daniel Gardner</name></author><author><name sortKey="Johnson, Maxwell" sort="Johnson, Maxwell" uniqKey="Johnson M" first="Maxwell" last="Johnson">Maxwell Johnson</name></author><author><name sortKey="Young Park, Sun" sort="Young Park, Sun" uniqKey="Young Park S" first="Sun" last="Young Park">Sun Young Park</name></author><author><name sortKey="Bramos, Athanasios" sort="Bramos, Athanasios" uniqKey="Bramos A" first="Athanasios" last="Bramos">Athanasios Bramos</name></author><author><name sortKey="Kyung Park, Eun" sort="Kyung Park, Eun" uniqKey="Kyung Park E" first="Eun" last="Kyung Park">Eun Kyung Park</name></author><author><name sortKey="Seong, Young Jin N" sort="Seong, Young Jin N" uniqKey="Seong Y" first="Young Jin N." last="Seong">Young Jin N. Seong</name></author><author><name sortKey="Lee, Sunju" sort="Lee, Sunju" uniqKey="Lee S" first="Sunju" last="Lee">Sunju Lee</name></author><author><name sortKey="Jung, Lia E" sort="Jung, Lia E" uniqKey="Jung L" first="Lia E." last="Jung">Lia E. Jung</name></author><author><name sortKey="Choi, Dongwon" sort="Choi, Dongwon" uniqKey="Choi D" first="Dongwon" last="Choi">Dongwon Choi</name></author><author><name sortKey="Hong, Young Kwon" sort="Hong, Young Kwon" uniqKey="Hong Y" first="Young-Kwon" last="Hong">Young-Kwon Hong</name></author><author><name sortKey="Wong, Alex K" sort="Wong, Alex K" uniqKey="Wong A" first="Alex K." last="Wong">Alex K. Wong</name></author></analytic><series><title level="j">Plastic and Reconstructive Surgery Global Open</title><idno type="eISSN">2169-7574</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader></TEI><pmc article-type="abstract"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Plast Reconstr Surg Glob Open</journal-id><journal-id journal-id-type="iso-abbrev">Plast Reconstr Surg Glob Open</journal-id><journal-id journal-id-type="publisher-id">GOX</journal-id><journal-title-group><journal-title>Plastic and Reconstructive Surgery Global Open</journal-title></journal-title-group><issn pub-type="epub">2169-7574</issn><publisher><publisher-name>Wolters Kluwer Health</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmc">5417988</article-id><article-id pub-id-type="art-access-id">00135</article-id><article-id pub-id-type="doi">10.1097/01.GOX.0000516655.76706.86</article-id><article-categories><subj-group subj-group-type="heading"><subject>PSRC 2017 Abstract Supplement</subject></subj-group></article-categories><title-group><article-title>Abstract 136: Short Duration 9-cis Retinoid Acid Therapy is Sufficient to Improve Functional Lymphatic Drainage in Post-Surgical Lymphedema</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Lee</surname><given-names>Gene K.</given-names></name><degrees>MD, MPH</degrees></contrib><contrib contrib-type="author"><name><surname>Perrault</surname><given-names>David P.</given-names></name><degrees>BS</degrees></contrib><contrib contrib-type="author"><name><surname>Bouz</surname><given-names>Antoun</given-names></name><degrees>BS</degrees></contrib><contrib contrib-type="author"><name><surname>Pourmoussa</surname><given-names>Austin J.</given-names></name><degrees>MS</degrees></contrib><contrib contrib-type="author"><name><surname>Gardner</surname><given-names>Daniel</given-names></name><degrees>BS</degrees></contrib><contrib contrib-type="author"><name><surname>Johnson</surname><given-names>Maxwell</given-names></name><degrees>MS</degrees></contrib><contrib contrib-type="author"><name><surname>Young Park</surname><given-names>Sun</given-names></name><degrees>MS</degrees></contrib><contrib contrib-type="author"><name><surname>Bramos</surname><given-names>Athanasios</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Kyung Park</surname><given-names>Eun</given-names></name><degrees>MS</degrees></contrib><contrib contrib-type="author"><name><surname>Seong</surname><given-names>Young Jin N.</given-names></name><degrees>BS</degrees></contrib><contrib contrib-type="author"><name><surname>Lee</surname><given-names>Sunju</given-names></name><degrees>PhD</degrees></contrib><contrib contrib-type="author"><name><surname>Jung</surname><given-names>Lia E.</given-names></name><degrees>MS</degrees></contrib><contrib contrib-type="author"><name><surname>Choi</surname><given-names>Dongwon</given-names></name><degrees>PhD</degrees></contrib><contrib contrib-type="author"><name><surname>Hong</surname><given-names>Young-Kwon</given-names></name><degrees>PhD</degrees></contrib><contrib contrib-type="author"><name><surname>Wong</surname><given-names>Alex K.</given-names></name><degrees>MD, FACS</degrees></contrib><aff>University of Southern California, Los Angeles, CA</aff></contrib-group><pub-date pub-type="collection"><month>4</month><year>2017</year></pub-date><pub-date pub-type="epub"><day>01</day><month>5</month><year>2017</year></pub-date><volume>5</volume><issue>4 Suppl</issue><supplement>PSRC 2017 Abstract Supplement</supplement><elocation-id>100</elocation-id><permissions><copyright-statement>Copyright © 2017 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of The American Society of Plastic Surgeons. All rights reserved.</copyright-statement><copyright-year>2017</copyright-year><license license-type="open-access"><license-p>This is an open-access article distributed under the terms of the <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc-nd/4.0/">Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND)</ext-link>, where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially.</license-p></license></permissions><self-uri xlink:type="simple" xlink:href="gox-5-100a.pdf"></self-uri><custom-meta-group><custom-meta><meta-name>OPEN-ACCESS</meta-name><meta-value>TRUE</meta-value></custom-meta></custom-meta-group></article-meta></front><body><p><bold>PURPOSE:</bold> 9-<italic>cis</italic> Retinoic Acid (9<italic>-cis</italic> RA), prevents postsurgical lymphedema and is associated with increased lymphangiogenesis and lymphatic clearance. In this study, we sought to determine if shorter durations of 9<italic>-cis</italic> RA therapy were sufficient to maintain the functional effect on post-surgical lymphatic clearance.</p><p><bold>METHODS:</bold> Fifty C57BL/6 mice underwent surgical induction of tail lymphedema. Treatment groups (n=10) included injection of 9-<italic>cis</italic> RA starting on post-operative day (POD) zero for either 7, 7 days at POD 7, 14, and 45 days. The control group was injected with a vehicle control for 45 days. On POD 42, indocyanine green (ICG) lymphangiography was performed. Lymphatic fluid clearance was quantified over time with Image J and student-t tests were calculated between each group at various time points using GraphPad Prism 6.</p><p><bold>RESULTS:</bold><italic>*Significant (p-value < 0.05) difference between the control group and all other treatment groups</italic></p><p><bold>CONCLUSIONS:</bold> The improvement in functional lymphatic flow in post-surgical lymphedema by 9-<italic>cis</italic> RA is present with 7 days, 7 days of delayed, 14 days and 45 days of therapy. The percent change in tail fluorescence on POD 42, upon injection of ICG as measured by SPY lymphangiography was significantly lower in all experimental groups overtime, compared to the vehicle control. 9<italic>-cis</italic> RA is a promising therapy for post-surgical lymphedema, even at shorter durations of therapy. A minimal effect dosing regimen has the potential to limit side effects of 9-<italic>cis</italic> RA systemic therapy.</p></body></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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