Abstract 104: Quantifying Real-Time Lymphatic Clearance of the Extremity Using Molecular Imaging: A Porcine Pilot Study
Identifieur interne : 001E12 ( Pmc/Corpus ); précédent : 001E11; suivant : 001E13Abstract 104: Quantifying Real-Time Lymphatic Clearance of the Extremity Using Molecular Imaging: A Porcine Pilot Study
Auteurs : Bao Ngoc Tran ; Qing Ruan ; Joe Angelo ; Rita Laurence ; Bernard Lee ; Dhruv SinghalSource :
- Plastic and Reconstructive Surgery Global Open [ 2169-7574 ] ; 2017.
Url:
DOI: 10.1097/01.GOX.0000516623.42159.40
PubMed: NONE
PubMed Central: 5417956
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Abstract 104: Quantifying Real-Time Lymphatic Clearance of the Extremity Using Molecular Imaging: A Porcine Pilot Study</title><author><name sortKey="Tran, Bao Ngoc" sort="Tran, Bao Ngoc" uniqKey="Tran B" first="Bao Ngoc" last="Tran">Bao Ngoc Tran</name><affiliation><nlm:aff id="aff1">Beth Israel Deaconess Medical Center, Boston, MA,</nlm:aff></affiliation></author><author><name sortKey="Ruan, Qing" sort="Ruan, Qing" uniqKey="Ruan Q" first="Qing" last="Ruan">Qing Ruan</name><affiliation><nlm:aff id="aff1">Beth Israel Deaconess Medical Center, Boston, MA,</nlm:aff></affiliation></author><author><name sortKey="Angelo, Joe" sort="Angelo, Joe" uniqKey="Angelo J" first="Joe" last="Angelo">Joe Angelo</name><affiliation><nlm:aff id="aff1">Beth Israel Deaconess Medical Center, Boston, MA,</nlm:aff></affiliation></author><author><name sortKey="Laurence, Rita" sort="Laurence, Rita" uniqKey="Laurence R" first="Rita" last="Laurence">Rita Laurence</name><affiliation><nlm:aff id="aff1">Brigham and Women’s Hospital, Boston, MA</nlm:aff></affiliation></author><author><name sortKey="Lee, Bernard" sort="Lee, Bernard" uniqKey="Lee B" first="Bernard" last="Lee">Bernard Lee</name><affiliation><nlm:aff id="aff1">Beth Israel Deaconess Medical Center, Boston, MA,</nlm:aff></affiliation></author><author><name sortKey="Singhal, Dhruv" sort="Singhal, Dhruv" uniqKey="Singhal D" first="Dhruv" last="Singhal">Dhruv Singhal</name><affiliation><nlm:aff id="aff1">Beth Israel Deaconess Medical Center, Boston, MA,</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmc">5417956</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5417956</idno><idno type="RBID">PMC:5417956</idno><idno type="doi">10.1097/01.GOX.0000516623.42159.40</idno><idno type="pmid">NONE</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">001E12</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001E12</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Abstract 104: Quantifying Real-Time Lymphatic Clearance of the Extremity Using Molecular Imaging: A Porcine Pilot Study</title><author><name sortKey="Tran, Bao Ngoc" sort="Tran, Bao Ngoc" uniqKey="Tran B" first="Bao Ngoc" last="Tran">Bao Ngoc Tran</name><affiliation><nlm:aff id="aff1">Beth Israel Deaconess Medical Center, Boston, MA,</nlm:aff></affiliation></author><author><name sortKey="Ruan, Qing" sort="Ruan, Qing" uniqKey="Ruan Q" first="Qing" last="Ruan">Qing Ruan</name><affiliation><nlm:aff id="aff1">Beth Israel Deaconess Medical Center, Boston, MA,</nlm:aff></affiliation></author><author><name sortKey="Angelo, Joe" sort="Angelo, Joe" uniqKey="Angelo J" first="Joe" last="Angelo">Joe Angelo</name><affiliation><nlm:aff id="aff1">Beth Israel Deaconess Medical Center, Boston, MA,</nlm:aff></affiliation></author><author><name sortKey="Laurence, Rita" sort="Laurence, Rita" uniqKey="Laurence R" first="Rita" last="Laurence">Rita Laurence</name><affiliation><nlm:aff id="aff1">Brigham and Women’s Hospital, Boston, MA</nlm:aff></affiliation></author><author><name sortKey="Lee, Bernard" sort="Lee, Bernard" uniqKey="Lee B" first="Bernard" last="Lee">Bernard Lee</name><affiliation><nlm:aff id="aff1">Beth Israel Deaconess Medical Center, Boston, MA,</nlm:aff></affiliation></author><author><name sortKey="Singhal, Dhruv" sort="Singhal, Dhruv" uniqKey="Singhal D" first="Dhruv" last="Singhal">Dhruv Singhal</name><affiliation><nlm:aff id="aff1">Beth Israel Deaconess Medical Center, Boston, MA,</nlm:aff></affiliation></author></analytic><series><title level="j">Plastic and Reconstructive Surgery Global Open</title><idno type="eISSN">2169-7574</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader></TEI><pmc article-type="abstract"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Plast Reconstr Surg Glob Open</journal-id><journal-id journal-id-type="iso-abbrev">Plast Reconstr Surg Glob Open</journal-id><journal-id journal-id-type="publisher-id">GOX</journal-id><journal-title-group><journal-title>Plastic and Reconstructive Surgery Global Open</journal-title></journal-title-group><issn pub-type="epub">2169-7574</issn><publisher><publisher-name>Wolters Kluwer Health</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmc">5417956</article-id><article-id pub-id-type="art-access-id">00103</article-id><article-id pub-id-type="doi">10.1097/01.GOX.0000516623.42159.40</article-id><article-categories><subj-group subj-group-type="heading"><subject>PSRC 2017 Abstract Supplement</subject></subj-group></article-categories><title-group><article-title>Abstract 104: Quantifying Real-Time Lymphatic Clearance of the Extremity Using Molecular Imaging: A Porcine Pilot Study</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Tran</surname><given-names>Bao Ngoc</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Ruan</surname><given-names>Qing</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Angelo</surname><given-names>Joe</given-names></name><degrees>MS</degrees><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Laurence</surname><given-names>Rita</given-names></name><degrees>BS</degrees><xref ref-type="aff" rid="aff1">2</xref></contrib><contrib contrib-type="author"><name><surname>Lee</surname><given-names>Bernard</given-names></name><degrees>MD, MPH, MBA, FACS</degrees><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Singhal</surname><given-names>Dhruv</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff1">1</xref></contrib><aff id="aff1"><label>1</label>Beth Israel Deaconess Medical Center, Boston, MA,<label>2</label>Brigham and Women’s Hospital, Boston, MA</aff></contrib-group><pub-date pub-type="collection"><month>4</month><year>2017</year></pub-date><pub-date pub-type="epub"><day>01</day><month>5</month><year>2017</year></pub-date><volume>5</volume><issue>4 Suppl</issue><supplement>PSRC 2017 Abstract Supplement</supplement><elocation-id>76-77</elocation-id><permissions><copyright-statement>Copyright © 2017 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of The American Society of Plastic Surgeons. All rights reserved.</copyright-statement><copyright-year>2017</copyright-year><license license-type="open-access"><license-p>This is an open-access article distributed under the terms of the <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc-nd/4.0/">Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND)</ext-link>, where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially.</license-p></license></permissions><self-uri xlink:type="simple" xlink:href="gox-5-076b.pdf"></self-uri><custom-meta-group><custom-meta><meta-name>OPEN-ACCESS</meta-name><meta-value>TRUE</meta-value></custom-meta></custom-meta-group></article-meta></front><body><p><bold>PURPOSE:</bold> Breast cancer related lymphedema affects more than 400,000 survivors in the United States. In 2009, Lymphatic Microsurgical Preventing Healing Approach (LYMPHA) was first described as a surgical technique to prevent lymphedema by performing a prophylactic bypass at the time of an axillary node dissection (ALND). We describe the first animal model evaluating the efficacy of LYMPHA.</p><p><bold>METHODS:</bold> In Yorkshire pigs, each distal hind limb lymphatic system was cannulated and injected with a different fluorophore (human serum albumin conjugated indocyanine green (ICG-HSA) or Evans Blue (EB-HSA)). Fluorescence-Assisted Resection and Exploration (FLARE) imaging was used to map the respective lymphatic systems. Lymphatic clearance of each hind limb was measured via fluorescence of each dye from centrally obtained blood samples. A lymphadenectomy (control side) versus lymphadenectomy with LYMPHA (study side) was then performed. The injections were then repeated.</p><p><bold>RESULTS:</bold> ICG-HSA and EB-HSA allowed for lymphatic mapping of each respective hind limb utilizing FLARE imaging. Lymphatic clearance of ICG-HSA from the distal hind limb dropped 64% when comparing no intervention versus a groin lymphadenectomy. In comparison, lymphatic clearance of EB-HSA dropped only 22% from the distal hind limb when comparing no intervention versus a lymphadenectomy with LYMPHA.</p><p><bold>CONCLUSION:</bold> We describe the first animal model for LYMPHA. Moreover, we demonstrate the power of molecular imaging to provide real time rates of lymphatic clearance for each respective hind limb.</p></body></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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