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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Recombinant interferon in advanced breast cancer.</title><author><name sortKey="Nethersell, A" sort="Nethersell, A" uniqKey="Nethersell A" first="A." last="Nethersell">A. Nethersell</name></author><author><name sortKey="Smedley, H" sort="Smedley, H" uniqKey="Smedley H" first="H." last="Smedley">H. Smedley</name></author><author><name sortKey="Katrak, M" sort="Katrak, M" uniqKey="Katrak M" first="M." last="Katrak">M. Katrak</name></author><author><name sortKey="Wheeler, T" sort="Wheeler, T" uniqKey="Wheeler T" first="T." last="Wheeler">T. Wheeler</name></author><author><name sortKey="Sikora, K" sort="Sikora, K" uniqKey="Sikora K" first="K." last="Sikora">K. Sikora</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">6722009</idno><idno type="pmc">1976731</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1976731</idno><idno type="RBID">PMC:1976731</idno><date when="1984">1984</date><idno type="wicri:Area/Pmc/Corpus">001B54</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001B54</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Recombinant interferon in advanced breast cancer.</title><author><name sortKey="Nethersell, A" sort="Nethersell, A" uniqKey="Nethersell A" first="A." last="Nethersell">A. Nethersell</name></author><author><name sortKey="Smedley, H" sort="Smedley, H" uniqKey="Smedley H" first="H." last="Smedley">H. Smedley</name></author><author><name sortKey="Katrak, M" sort="Katrak, M" uniqKey="Katrak M" first="M." last="Katrak">M. Katrak</name></author><author><name sortKey="Wheeler, T" sort="Wheeler, T" uniqKey="Wheeler T" first="T." last="Wheeler">T. Wheeler</name></author><author><name sortKey="Sikora, K" sort="Sikora, K" uniqKey="Sikora K" first="K." last="Sikora">K. Sikora</name></author></analytic><series><title level="j">British Journal of Cancer</title><idno type="ISSN">0007-0920</idno><idno type="eISSN">1532-1827</idno><imprint><date when="1984">1984</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Fifteen patients with locally advanced refractory breast cancer have been treated with recombinant leucocyte interferon ( rIFN -alpha A) for up to 12 weeks. Toxicity was considerable with the initial dosage schedule employed but became acceptable after reducing the starting dose by 50%. Minor side effects occurred in all patients and major CNS toxicity in six. Nine patients showed some evidence of tumour regression at 4 weeks. Only two of these were still responding at 12 weeks. Response was unrelated to the length of previous history, oestrogen receptor status or previous responsiveness to cytotoxic or hormone therapy.</p></div></front></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Br J Cancer</journal-id><journal-title>British Journal of Cancer</journal-title><issn pub-type="ppub">0007-0920</issn><issn pub-type="epub">1532-1827</issn></journal-meta><article-meta><article-id pub-id-type="pmid">6722009</article-id><article-id pub-id-type="pmc">1976731</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title>Recombinant interferon in advanced breast cancer.</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Nethersell</surname><given-names>A.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Smedley</surname><given-names>H.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Katrak</surname><given-names>M.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Wheeler</surname><given-names>T.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Sikora</surname><given-names>K.</given-names></name></contrib></contrib-group><pub-date pub-type="ppub"><month>5</month><year>1984</year></pub-date><volume>49</volume><issue>5</issue><fpage>615</fpage><lpage>620</lpage><abstract><p>Fifteen patients with locally advanced refractory breast cancer have been treated with recombinant leucocyte interferon ( rIFN -alpha A) for up to 12 weeks. Toxicity was considerable with the initial dosage schedule employed but became acceptable after reducing the starting dose by 50%. Minor side effects occurred in all patients and major CNS toxicity in six. Nine patients showed some evidence of tumour regression at 4 weeks. Only two of these were still responding at 12 weeks. Response was unrelated to the length of previous history, oestrogen receptor status or previous responsiveness to cytotoxic or hormone therapy.</p></abstract></article-meta></front><body><supplementary-material content-type="scanned-pages"><graphic xlink:href="brjcancer00115-0064.tif" xlink:title="scanned-page" xlink:role="615" mimetype="image" mime-subtype="tiff"></graphic><graphic xlink:href="brjcancer00115-0065.tif" xlink:title="scanned-page" xlink:role="616" mimetype="image" mime-subtype="tiff"></graphic><graphic xlink:href="brjcancer00115-0066.tif" xlink:title="scanned-page" xlink:role="617" mimetype="image" mime-subtype="tiff"></graphic><graphic xlink:href="brjcancer00115-0067.tif" xlink:title="scanned-page" xlink:role="618" mimetype="image" mime-subtype="tiff"></graphic><graphic xlink:href="brjcancer00115-0068.tif" xlink:title="scanned-page" xlink:role="619" mimetype="image" mime-subtype="tiff"></graphic><graphic xlink:href="brjcancer00115-0069.tif" xlink:title="scanned-page" xlink:role="620" mimetype="image" mime-subtype="tiff"></graphic></supplementary-material></body></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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