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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Recombinant interferon in advanced breast cancer.</title>
<author><name sortKey="Nethersell, A" sort="Nethersell, A" uniqKey="Nethersell A" first="A." last="Nethersell">A. Nethersell</name>
</author>
<author><name sortKey="Smedley, H" sort="Smedley, H" uniqKey="Smedley H" first="H." last="Smedley">H. Smedley</name>
</author>
<author><name sortKey="Katrak, M" sort="Katrak, M" uniqKey="Katrak M" first="M." last="Katrak">M. Katrak</name>
</author>
<author><name sortKey="Wheeler, T" sort="Wheeler, T" uniqKey="Wheeler T" first="T." last="Wheeler">T. Wheeler</name>
</author>
<author><name sortKey="Sikora, K" sort="Sikora, K" uniqKey="Sikora K" first="K." last="Sikora">K. Sikora</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">6722009</idno>
<idno type="pmc">1976731</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1976731</idno>
<idno type="RBID">PMC:1976731</idno>
<date when="1984">1984</date>
<idno type="wicri:Area/Pmc/Corpus">001B54</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001B54</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Recombinant interferon in advanced breast cancer.</title>
<author><name sortKey="Nethersell, A" sort="Nethersell, A" uniqKey="Nethersell A" first="A." last="Nethersell">A. Nethersell</name>
</author>
<author><name sortKey="Smedley, H" sort="Smedley, H" uniqKey="Smedley H" first="H." last="Smedley">H. Smedley</name>
</author>
<author><name sortKey="Katrak, M" sort="Katrak, M" uniqKey="Katrak M" first="M." last="Katrak">M. Katrak</name>
</author>
<author><name sortKey="Wheeler, T" sort="Wheeler, T" uniqKey="Wheeler T" first="T." last="Wheeler">T. Wheeler</name>
</author>
<author><name sortKey="Sikora, K" sort="Sikora, K" uniqKey="Sikora K" first="K." last="Sikora">K. Sikora</name>
</author>
</analytic>
<series><title level="j">British Journal of Cancer</title>
<idno type="ISSN">0007-0920</idno>
<idno type="eISSN">1532-1827</idno>
<imprint><date when="1984">1984</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Fifteen patients with locally advanced refractory breast cancer have been treated with recombinant leucocyte interferon ( rIFN -alpha A) for up to 12 weeks. Toxicity was considerable with the initial dosage schedule employed but became acceptable after reducing the starting dose by 50%. Minor side effects occurred in all patients and major CNS toxicity in six. Nine patients showed some evidence of tumour regression at 4 weeks. Only two of these were still responding at 12 weeks. Response was unrelated to the length of previous history, oestrogen receptor status or previous responsiveness to cytotoxic or hormone therapy.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Br J Cancer</journal-id>
<journal-title>British Journal of Cancer</journal-title>
<issn pub-type="ppub">0007-0920</issn>
<issn pub-type="epub">1532-1827</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">6722009</article-id>
<article-id pub-id-type="pmc">1976731</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Recombinant interferon in advanced breast cancer.</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Nethersell</surname>
<given-names>A.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Smedley</surname>
<given-names>H.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Katrak</surname>
<given-names>M.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Wheeler</surname>
<given-names>T.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Sikora</surname>
<given-names>K.</given-names>
</name>
</contrib>
</contrib-group>
<pub-date pub-type="ppub"><month>5</month>
<year>1984</year>
</pub-date>
<volume>49</volume>
<issue>5</issue>
<fpage>615</fpage>
<lpage>620</lpage>
<abstract><p>Fifteen patients with locally advanced refractory breast cancer have been treated with recombinant leucocyte interferon ( rIFN -alpha A) for up to 12 weeks. Toxicity was considerable with the initial dosage schedule employed but became acceptable after reducing the starting dose by 50%. Minor side effects occurred in all patients and major CNS toxicity in six. Nine patients showed some evidence of tumour regression at 4 weeks. Only two of these were still responding at 12 weeks. Response was unrelated to the length of previous history, oestrogen receptor status or previous responsiveness to cytotoxic or hormone therapy.</p>
</abstract>
</article-meta>
</front>
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</supplementary-material>
</body>
</pmc>
</record>
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