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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Role of Gamma Interferon and Interleukin-4 in Host Defense against the Human Filarial Parasite <italic>Brugia malayi</italic>
</title>
<author><name sortKey="Babu, Subash" sort="Babu, Subash" uniqKey="Babu S" first="Subash" last="Babu">Subash Babu</name>
<affiliation><nlm:aff id="N0x993a4d0.0xa4c60f8"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ganley, Lisa M" sort="Ganley, Lisa M" uniqKey="Ganley L" first="Lisa M." last="Ganley">Lisa M. Ganley</name>
<affiliation><nlm:aff id="N0x993a4d0.0xa4c60f8"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Klei, Thomas R" sort="Klei, Thomas R" uniqKey="Klei T" first="Thomas R." last="Klei">Thomas R. Klei</name>
<affiliation><nlm:aff id="N0x993a4d0.0xa4c60f8"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Shultz, Leonard D" sort="Shultz, Leonard D" uniqKey="Shultz L" first="Leonard D." last="Shultz">Leonard D. Shultz</name>
<affiliation><nlm:aff id="N0x993a4d0.0xa4c60f8"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Rajan, T V" sort="Rajan, T V" uniqKey="Rajan T" first="T. V." last="Rajan">T. V. Rajan</name>
<affiliation><nlm:aff id="N0x993a4d0.0xa4c60f8"></nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">10769010</idno>
<idno type="pmc">97525</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC97525</idno>
<idno type="RBID">PMC:97525</idno>
<date when="2000">2000</date>
<idno type="wicri:Area/Pmc/Corpus">000B46</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000B46</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Role of Gamma Interferon and Interleukin-4 in Host Defense against the Human Filarial Parasite <italic>Brugia malayi</italic>
</title>
<author><name sortKey="Babu, Subash" sort="Babu, Subash" uniqKey="Babu S" first="Subash" last="Babu">Subash Babu</name>
<affiliation><nlm:aff id="N0x993a4d0.0xa4c60f8"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ganley, Lisa M" sort="Ganley, Lisa M" uniqKey="Ganley L" first="Lisa M." last="Ganley">Lisa M. Ganley</name>
<affiliation><nlm:aff id="N0x993a4d0.0xa4c60f8"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Klei, Thomas R" sort="Klei, Thomas R" uniqKey="Klei T" first="Thomas R." last="Klei">Thomas R. Klei</name>
<affiliation><nlm:aff id="N0x993a4d0.0xa4c60f8"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Shultz, Leonard D" sort="Shultz, Leonard D" uniqKey="Shultz L" first="Leonard D." last="Shultz">Leonard D. Shultz</name>
<affiliation><nlm:aff id="N0x993a4d0.0xa4c60f8"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Rajan, T V" sort="Rajan, T V" uniqKey="Rajan T" first="T. V." last="Rajan">T. V. Rajan</name>
<affiliation><nlm:aff id="N0x993a4d0.0xa4c60f8"></nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Infection and Immunity</title>
<idno type="ISSN">0019-9567</idno>
<idno type="eISSN">1098-5522</idno>
<imprint><date when="2000">2000</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>We have investigated the roles of gamma interferon (IFN-γ) and interleukin-4 (IL-4) in host defense against <italic>Brugia malayi</italic>
. Our data suggest that the lack of either IFN-γ or IL-4 prolongs the time required to achieve sterile immunity, suggesting that both canonical type 1 and type 2 responses are involved in the clearance of infection.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Infect Immun</journal-id>
<journal-id journal-id-type="publisher-id">INFECT IMMUN</journal-id>
<journal-title>Infection and Immunity</journal-title>
<issn pub-type="ppub">0019-9567</issn>
<issn pub-type="epub">1098-5522</issn>
<publisher><publisher-name>American Society for Microbiology</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">10769010</article-id>
<article-id pub-id-type="pmc">97525</article-id>
<article-id pub-id-type="publisher-id">1699</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Fungal and Parasitic Infections</subject>
</subj-group>
<series-title>Note</series-title>
</article-categories>
<title-group><article-title>Role of Gamma Interferon and Interleukin-4 in Host Defense against the Human Filarial Parasite <italic>Brugia malayi</italic>
</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Babu</surname>
<given-names>Subash</given-names>
</name>
<xref ref-type="aff" rid="N0x993a4d0.0xa4c60f8">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ganley</surname>
<given-names>Lisa M.</given-names>
</name>
<xref ref-type="aff" rid="N0x993a4d0.0xa4c60f8">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Klei</surname>
<given-names>Thomas R.</given-names>
</name>
<xref ref-type="aff" rid="N0x993a4d0.0xa4c60f8">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Shultz</surname>
<given-names>Leonard D.</given-names>
</name>
<xref ref-type="aff" rid="N0x993a4d0.0xa4c60f8">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Rajan</surname>
<given-names>T. V.</given-names>
</name>
<xref ref-type="aff" rid="N0x993a4d0.0xa4c60f8">1</xref>
<xref ref-type="author-notes" rid="FN150">*</xref>
</contrib>
</contrib-group>
<aff id="N0x993a4d0.0xa4c60f8"> Department of Pathology, University of Connecticut Health Center, Farmington, Connecticut 06030-3105<sup>1</sup>
; Department of Veterinary Microbiology and Parasitology, Louisiana State University, Baton Rouge, Louisiana 70803-8416<sup>2</sup>
; and The Jackson Laboratory, Bar Harbor, Maine 04609<sup>3</sup>
</aff>
<contrib-group><contrib contrib-type="editor"><name><surname>Mansfield</surname>
<given-names>J. M.</given-names>
</name>
</contrib>
</contrib-group>
<author-notes><fn id="FN150"><label>*</label>
<p>Corresponding author. Mailing address: Department of Pathology, University of Connecticut Health Center, Farmington, CT 06030-3105. Phone: (860) 679-3221. Fax: (860) 679-2936. E-mail: <email>rajan@neuron.uchc.edu</email>
.</p>
</fn>
</author-notes>
<pub-date pub-type="ppub"><month>5</month>
<year>2000</year>
</pub-date>
<volume>68</volume>
<issue>5</issue>
<fpage>3034</fpage>
<lpage>3035</lpage>
<history><date date-type="received"><day>18</day>
<month>11</month>
<year>1999</year>
</date>
<date date-type="rev-request"><day>4</day>
<month>1</month>
<year>2000</year>
</date>
<date date-type="accepted"><day>11</day>
<month>2</month>
<year>2000</year>
</date>
</history>
<copyright-statement>Copyright © 2000, American Society for Microbiology</copyright-statement>
<copyright-year>2000</copyright-year>
<abstract><p>We have investigated the roles of gamma interferon (IFN-γ) and interleukin-4 (IL-4) in host defense against <italic>Brugia malayi</italic>
. Our data suggest that the lack of either IFN-γ or IL-4 prolongs the time required to achieve sterile immunity, suggesting that both canonical type 1 and type 2 responses are involved in the clearance of infection.</p>
</abstract>
</article-meta>
</front>
</pmc>
</record>
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