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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Perturbations in Eosinophil Homeostasis following Treatment of Lymphatic Filariasis</title>
<author><name sortKey="Gopinath, Ramya" sort="Gopinath, Ramya" uniqKey="Gopinath R" first="Ramya" last="Gopinath">Ramya Gopinath</name>
<affiliation><nlm:aff id="N0x97c4870.0x9c870f8"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hanna, L E" sort="Hanna, L E" uniqKey="Hanna L" first="L. E." last="Hanna">L. E. Hanna</name>
<affiliation><nlm:aff id="N0x97c4870.0x9c870f8"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kumaraswami, V" sort="Kumaraswami, V" uniqKey="Kumaraswami V" first="V." last="Kumaraswami">V. Kumaraswami</name>
<affiliation><nlm:aff id="N0x97c4870.0x9c870f8"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Perumal, V" sort="Perumal, V" uniqKey="Perumal V" first="V." last="Perumal">V. Perumal</name>
<affiliation><nlm:aff id="N0x97c4870.0x9c870f8"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kavitha, V" sort="Kavitha, V" uniqKey="Kavitha V" first="V." last="Kavitha">V. Kavitha</name>
<affiliation><nlm:aff id="N0x97c4870.0x9c870f8"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Vijayasekaran, V" sort="Vijayasekaran, V" uniqKey="Vijayasekaran V" first="V." last="Vijayasekaran">V. Vijayasekaran</name>
<affiliation><nlm:aff id="N0x97c4870.0x9c870f8"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Nutman, Thomas B" sort="Nutman, Thomas B" uniqKey="Nutman T" first="Thomas B." last="Nutman">Thomas B. Nutman</name>
<affiliation><nlm:aff id="N0x97c4870.0x9c870f8"></nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">10603373</idno>
<idno type="pmc">97106</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC97106</idno>
<idno type="RBID">PMC:97106</idno>
<date when="2000">2000</date>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Perturbations in Eosinophil Homeostasis following Treatment of Lymphatic Filariasis</title>
<author><name sortKey="Gopinath, Ramya" sort="Gopinath, Ramya" uniqKey="Gopinath R" first="Ramya" last="Gopinath">Ramya Gopinath</name>
<affiliation><nlm:aff id="N0x97c4870.0x9c870f8"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hanna, L E" sort="Hanna, L E" uniqKey="Hanna L" first="L. E." last="Hanna">L. E. Hanna</name>
<affiliation><nlm:aff id="N0x97c4870.0x9c870f8"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kumaraswami, V" sort="Kumaraswami, V" uniqKey="Kumaraswami V" first="V." last="Kumaraswami">V. Kumaraswami</name>
<affiliation><nlm:aff id="N0x97c4870.0x9c870f8"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Perumal, V" sort="Perumal, V" uniqKey="Perumal V" first="V." last="Perumal">V. Perumal</name>
<affiliation><nlm:aff id="N0x97c4870.0x9c870f8"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kavitha, V" sort="Kavitha, V" uniqKey="Kavitha V" first="V." last="Kavitha">V. Kavitha</name>
<affiliation><nlm:aff id="N0x97c4870.0x9c870f8"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Vijayasekaran, V" sort="Vijayasekaran, V" uniqKey="Vijayasekaran V" first="V." last="Vijayasekaran">V. Vijayasekaran</name>
<affiliation><nlm:aff id="N0x97c4870.0x9c870f8"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Nutman, Thomas B" sort="Nutman, Thomas B" uniqKey="Nutman T" first="Thomas B." last="Nutman">Thomas B. Nutman</name>
<affiliation><nlm:aff id="N0x97c4870.0x9c870f8"></nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Infection and Immunity</title>
<idno type="ISSN">0019-9567</idno>
<idno type="eISSN">1098-5522</idno>
<imprint><date when="2000">2000</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Treatment of patients with patent <italic>Wuchereria bancrofti</italic>
infection results in an acute clinical reaction and peripheral eosinophilia. To investigate the dynamics of the eosinophil response, changes in eosinophil activation and degranulation and plasma levels of eosinophil-active chemokines and cytokines were studied in 15 microfilaremic individuals in south India by sequential blood sampling before and after administration of 300 mg of diethylcarbamazine (DEC). Clinical symptoms occurred within 24 h. Plasma interleukin-5 (IL-5) and RANTES levels peaked 1 to 2 days posttreatment, preceding a peak peripheral eosinophil count at day 4. Major basic protein secretion from eosinophils paralleled IL-5 secretion, while levels of eosinophil-derived neurotoxin peaked at day 13 after treatment. Expression of the activation markers HLA-DR and CD25 on eosinophils rose markedly immediately after treatment, while expression of VLA-4 and α4β7 showed an early peak within 24 h and a second peak at day 13. Thus, the posttreatment reactions seen in filarial infections can be divided into an early phase with killing of microfilariae, clinical symptomatology, increases in plasma IL-5 and RANTES levels, and eosinophil activation and degranulation and a later phase with expression of surface integrins on eosinophils, recruitment of eosinophils from the bone marrow to tissues, and clearance of parasite antigen.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Infect Immun</journal-id>
<journal-id journal-id-type="publisher-id">INFECT IMMUN</journal-id>
<journal-title>Infection and Immunity</journal-title>
<issn pub-type="ppub">0019-9567</issn>
<issn pub-type="epub">1098-5522</issn>
<publisher><publisher-name>American Society for Microbiology</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">10603373</article-id>
<article-id pub-id-type="pmc">97106</article-id>
<article-id pub-id-type="publisher-id">0830</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Host Response and Inflammation</subject>
</subj-group>
</article-categories>
<title-group><article-title>Perturbations in Eosinophil Homeostasis following Treatment of Lymphatic Filariasis</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Gopinath</surname>
<given-names>Ramya</given-names>
</name>
<xref ref-type="aff" rid="N0x97c4870.0x9c870f8">1</xref>
<xref ref-type="author-notes" rid="FN150">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hanna</surname>
<given-names>L. E.</given-names>
</name>
<xref ref-type="aff" rid="N0x97c4870.0x9c870f8">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kumaraswami</surname>
<given-names>V.</given-names>
</name>
<xref ref-type="aff" rid="N0x97c4870.0x9c870f8">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Perumal</surname>
<given-names>V.</given-names>
</name>
<xref ref-type="aff" rid="N0x97c4870.0x9c870f8">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kavitha</surname>
<given-names>V.</given-names>
</name>
<xref ref-type="aff" rid="N0x97c4870.0x9c870f8">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Vijayasekaran</surname>
<given-names>V.</given-names>
</name>
<xref ref-type="aff" rid="N0x97c4870.0x9c870f8">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Nutman</surname>
<given-names>Thomas B.</given-names>
</name>
<xref ref-type="aff" rid="N0x97c4870.0x9c870f8">1</xref>
</contrib>
</contrib-group>
<aff id="N0x97c4870.0x9c870f8"> Helminth Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892,<sup>1</sup>
and Tuberculosis Research Centre<sup>2</sup>
and Government General Hospital,<sup>3</sup>
Madras, India</aff>
<contrib-group><contrib contrib-type="editor"><name><surname>Mansfield</surname>
<given-names>J. M.</given-names>
</name>
</contrib>
</contrib-group>
<author-notes><fn id="FN150"><label>*</label>
<p>Corresponding author. Mailing address: LPD, NIAID, Building 4, Room 126, NIH, Bethesda, MD 20892. Phone: (301) 496-3449. Fax: (301) 480-3757. E-mail: <email>rgopinath@niaid.nih.gov</email>
.</p>
</fn>
</author-notes>
<pub-date pub-type="ppub"><month>1</month>
<year>2000</year>
</pub-date>
<volume>68</volume>
<issue>1</issue>
<fpage>93</fpage>
<lpage>99</lpage>
<history><date date-type="received"><day>11</day>
<month>6</month>
<year>1999</year>
</date>
<date date-type="rev-request"><day>6</day>
<month>8</month>
<year>1999</year>
</date>
<date date-type="accepted"><day>6</day>
<month>10</month>
<year>1999</year>
</date>
</history>
<copyright-statement>Copyright © 2000, American Society for Microbiology</copyright-statement>
<copyright-year>2000</copyright-year>
<abstract><p>Treatment of patients with patent <italic>Wuchereria bancrofti</italic>
infection results in an acute clinical reaction and peripheral eosinophilia. To investigate the dynamics of the eosinophil response, changes in eosinophil activation and degranulation and plasma levels of eosinophil-active chemokines and cytokines were studied in 15 microfilaremic individuals in south India by sequential blood sampling before and after administration of 300 mg of diethylcarbamazine (DEC). Clinical symptoms occurred within 24 h. Plasma interleukin-5 (IL-5) and RANTES levels peaked 1 to 2 days posttreatment, preceding a peak peripheral eosinophil count at day 4. Major basic protein secretion from eosinophils paralleled IL-5 secretion, while levels of eosinophil-derived neurotoxin peaked at day 13 after treatment. Expression of the activation markers HLA-DR and CD25 on eosinophils rose markedly immediately after treatment, while expression of VLA-4 and α4β7 showed an early peak within 24 h and a second peak at day 13. Thus, the posttreatment reactions seen in filarial infections can be divided into an early phase with killing of microfilariae, clinical symptomatology, increases in plasma IL-5 and RANTES levels, and eosinophil activation and degranulation and a later phase with expression of surface integrins on eosinophils, recruitment of eosinophils from the bone marrow to tissues, and clearance of parasite antigen.</p>
</abstract>
</article-meta>
</front>
</pmc>
</record>
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