Human Lymphatic Architecture and Dynamic Transport Imaged Using Near-infrared Fluorescence12
Identifieur interne : 003393 ( Pmc/Checkpoint ); précédent : 003392; suivant : 003394Human Lymphatic Architecture and Dynamic Transport Imaged Using Near-infrared Fluorescence12
Auteurs : John C. Rasmussen [États-Unis] ; I-Chih Tan [États-Unis] ; Milton V. Marshall [États-Unis] ; Kristen E. Adams [États-Unis] ; Sunkuk Kwon [États-Unis] ; Caroline E. Fife [États-Unis] ; Erik A. Maus [États-Unis] ; Latisha A. Smith [États-Unis] ; Kyle R. Covington [États-Unis] ; Eva M. Sevick-Muraca [États-Unis]Source :
- Translational Oncology [ 1936-5233 ] ; 2010.
Abstract
Url:
PubMed: 21151475
PubMed Central: 3000461
Affiliations:
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PMC:3000461Le document en format XML
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<author><name sortKey="Maus, Erik A" sort="Maus, Erik A" uniqKey="Maus E" first="Erik A" last="Maus">Erik A. Maus</name>
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<wicri:noRegion>TX</wicri:noRegion>
</affiliation>
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<author><name sortKey="Smith, Latisha A" sort="Smith, Latisha A" uniqKey="Smith L" first="Latisha A" last="Smith">Latisha A. Smith</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Internal Medicine, Division of Cardiology and Hyperbaric Medicine at The University of Texas Health Science Center at Houston, Houston, TX</wicri:regionArea>
<wicri:noRegion>TX</wicri:noRegion>
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<affiliation wicri:level="1"><nlm:aff id="A3">Memorial Hermann Hospital, Center for Lymphedema Management, Houston, TX, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
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<wicri:noRegion>TX</wicri:noRegion>
</affiliation>
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<author><name sortKey="Covington, Kyle R" sort="Covington, Kyle R" uniqKey="Covington K" first="Kyle R" last="Covington">Kyle R. Covington</name>
<affiliation wicri:level="1"><nlm:aff id="A2">Department of Internal Medicine, Division of Cardiology and Hyperbaric Medicine at The University of Texas Health Science Center at Houston, Houston, TX, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Internal Medicine, Division of Cardiology and Hyperbaric Medicine at The University of Texas Health Science Center at Houston, Houston, TX</wicri:regionArea>
<wicri:noRegion>TX</wicri:noRegion>
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<affiliation wicri:level="1"><nlm:aff id="A3">Memorial Hermann Hospital, Center for Lymphedema Management, Houston, TX, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Memorial Hermann Hospital, Center for Lymphedema Management, Houston, TX</wicri:regionArea>
<wicri:noRegion>TX</wicri:noRegion>
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<author><name sortKey="Sevick Muraca, Eva M" sort="Sevick Muraca, Eva M" uniqKey="Sevick Muraca E" first="Eva M" last="Sevick-Muraca">Eva M. Sevick-Muraca</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, TX</wicri:regionArea>
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<imprint><date when="2010">2010</date>
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<front><div type="abstract" xml:lang="en"><p><italic>BACKGROUND:</italic>
Although the importance of lymphatic function is well recognized, the lack of real-time imaging modalities limits our understanding of its role in many diseases. In a phase 0 exploratory study, we used dynamic, near-infrared (NIR) fluorescence imaging to assess the extremes of lymphatic architecture and transport in healthy human subjects and in subjects clinically diagnosed with unilateral lymphedema (LE), a disease that can be prevalent in cancer survivors. <italic>METHODS AND RESULTS:</italic>
Active lymphatic propulsion was imaged after intradermal injections of 25 <italic>µ</italic>
g of indocyanine green (total maximum dose ≤400 <italic>µ</italic>
g) bilaterally in the arms or legs of control and subjects. Images show well-defined lymphatic structures with propulsive dye transport in limbs of healthy subjects. In LE subjects, we observed extravascular dye accumulation, networks of fluorescent lymphatic capillaries, and/or tortuous lymphatic vessels in all symptomatic and some asymptomatic limbs. Statistical models indicate that disease status and/or limb significantly affect parameters of apparent lymph propagation velocity and contractile frequency. <italic>CONCLUSIONS:</italic>
These clinical research studies demonstrate the potential of NIR fluorescence imaging as a diagnostic measure of functional lymphatics and as a new tool in translational research studies to decipher the role of the lymphatic system in cancer and other diseases.</p>
</div>
</front>
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<front><journal-meta><journal-id journal-id-type="nlm-ta">Transl Oncol</journal-id>
<journal-id journal-id-type="publisher-id">TLO</journal-id>
<journal-title-group><journal-title>Translational Oncology</journal-title>
</journal-title-group>
<issn pub-type="epub">1936-5233</issn>
<publisher><publisher-name>Neoplasia Press Inc.</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">21151475</article-id>
<article-id pub-id-type="pmc">3000461</article-id>
<article-id pub-id-type="publisher-id">10190</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Human Lymphatic Architecture and Dynamic Transport Imaged Using Near-infrared Fluorescence<xref ref-type="fn" rid="FN1">1</xref>
<xref ref-type="fn" rid="FN2">2</xref>
</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Rasmussen</surname>
<given-names>John C</given-names>
</name>
<xref ref-type="aff" rid="A1">*</xref>
<xref ref-type="author-notes" rid="FN3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Tan</surname>
<given-names>I-Chih</given-names>
</name>
<xref ref-type="aff" rid="A1">*</xref>
<xref ref-type="author-notes" rid="FN3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Marshall</surname>
<given-names>Milton V</given-names>
</name>
<xref ref-type="aff" rid="A1">*</xref>
<xref ref-type="author-notes" rid="FN3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Adams</surname>
<given-names>Kristen E</given-names>
</name>
<xref ref-type="aff" rid="A1">*</xref>
<xref ref-type="author-notes" rid="FN3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kwon</surname>
<given-names>Sunkuk</given-names>
</name>
<xref ref-type="aff" rid="A1">*</xref>
<xref ref-type="author-notes" rid="FN3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Fife</surname>
<given-names>Caroline E</given-names>
</name>
<xref ref-type="aff" rid="A2">†</xref>
<xref ref-type="aff" rid="A3">‡</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Maus</surname>
<given-names>Erik A</given-names>
</name>
<xref ref-type="aff" rid="A2">†</xref>
<xref ref-type="aff" rid="A3">‡</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Smith</surname>
<given-names>Latisha A</given-names>
</name>
<xref ref-type="aff" rid="A2">†</xref>
<xref ref-type="aff" rid="A3">‡</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Covington</surname>
<given-names>Kyle R</given-names>
</name>
<xref ref-type="aff" rid="A2">†</xref>
<xref ref-type="aff" rid="A3">‡</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sevick-Muraca</surname>
<given-names>Eva M</given-names>
</name>
<xref ref-type="aff" rid="A4">§</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>*</label>
Center for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine at the University of Texas Health Science Center at Houston, Houston, TX, USA</aff>
<aff id="A2"><label>†</label>
Department of Internal Medicine, Division of Cardiology and Hyperbaric Medicine at The University of Texas Health Science Center at Houston, Houston, TX, USA</aff>
<aff id="A3"><label>‡</label>
Memorial Hermann Hospital, Center for Lymphedema Management, Houston, TX, USA</aff>
<aff id="A4"><label>§</label>
Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, TX, USA</aff>
<author-notes><corresp>Address all correspondence to: Eva M. Sevick-Muraca, Center for Molecular Imaging, The Brown Foundation of Molecular Medicine, The University of Texas Health Science Center, SRB 330A, Houston, TX 77030. E-mail: <email>eva.sevick@uth.tmc.edu</email>
</corresp>
<fn fn-type="current-aff" id="FN3"><label>3</label>
<p>Formerly of the Department of Radiology, Baylor College of Medicine, Houston, TX. Portions of this work were conducted at Baylor College of Medicine.</p>
</fn>
</author-notes>
<pub-date pub-type="epub"><day>1</day>
<month>12</month>
<year>2010</year>
</pub-date>
<pub-date pub-type="collection"><month>12</month>
<year>2010</year>
</pub-date>
<volume>3</volume>
<issue>6</issue>
<fpage>362</fpage>
<lpage>372</lpage>
<history><date date-type="received"><day>8</day>
<month>7</month>
<year>2010</year>
</date>
<date date-type="rev-recd"><day>26</day>
<month>8</month>
<year>2010</year>
</date>
<date date-type="accepted"><day>30</day>
<month>8</month>
<year>2010</year>
</date>
</history>
<permissions><copyright-statement>Copyright © 2010 Neoplasia Press, Inc. All rights reserved</copyright-statement>
</permissions>
<abstract><p><italic>BACKGROUND:</italic>
Although the importance of lymphatic function is well recognized, the lack of real-time imaging modalities limits our understanding of its role in many diseases. In a phase 0 exploratory study, we used dynamic, near-infrared (NIR) fluorescence imaging to assess the extremes of lymphatic architecture and transport in healthy human subjects and in subjects clinically diagnosed with unilateral lymphedema (LE), a disease that can be prevalent in cancer survivors. <italic>METHODS AND RESULTS:</italic>
Active lymphatic propulsion was imaged after intradermal injections of 25 <italic>µ</italic>
g of indocyanine green (total maximum dose ≤400 <italic>µ</italic>
g) bilaterally in the arms or legs of control and subjects. Images show well-defined lymphatic structures with propulsive dye transport in limbs of healthy subjects. In LE subjects, we observed extravascular dye accumulation, networks of fluorescent lymphatic capillaries, and/or tortuous lymphatic vessels in all symptomatic and some asymptomatic limbs. Statistical models indicate that disease status and/or limb significantly affect parameters of apparent lymph propagation velocity and contractile frequency. <italic>CONCLUSIONS:</italic>
These clinical research studies demonstrate the potential of NIR fluorescence imaging as a diagnostic measure of functional lymphatics and as a new tool in translational research studies to decipher the role of the lymphatic system in cancer and other diseases.</p>
</abstract>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>États-Unis</li>
</country>
</list>
<tree><country name="États-Unis"><noRegion><name sortKey="Rasmussen, John C" sort="Rasmussen, John C" uniqKey="Rasmussen J" first="John C" last="Rasmussen">John C. Rasmussen</name>
</noRegion>
<name sortKey="Adams, Kristen E" sort="Adams, Kristen E" uniqKey="Adams K" first="Kristen E" last="Adams">Kristen E. Adams</name>
<name sortKey="Covington, Kyle R" sort="Covington, Kyle R" uniqKey="Covington K" first="Kyle R" last="Covington">Kyle R. Covington</name>
<name sortKey="Covington, Kyle R" sort="Covington, Kyle R" uniqKey="Covington K" first="Kyle R" last="Covington">Kyle R. Covington</name>
<name sortKey="Fife, Caroline E" sort="Fife, Caroline E" uniqKey="Fife C" first="Caroline E" last="Fife">Caroline E. Fife</name>
<name sortKey="Fife, Caroline E" sort="Fife, Caroline E" uniqKey="Fife C" first="Caroline E" last="Fife">Caroline E. Fife</name>
<name sortKey="Kwon, Sunkuk" sort="Kwon, Sunkuk" uniqKey="Kwon S" first="Sunkuk" last="Kwon">Sunkuk Kwon</name>
<name sortKey="Marshall, Milton V" sort="Marshall, Milton V" uniqKey="Marshall M" first="Milton V" last="Marshall">Milton V. Marshall</name>
<name sortKey="Maus, Erik A" sort="Maus, Erik A" uniqKey="Maus E" first="Erik A" last="Maus">Erik A. Maus</name>
<name sortKey="Maus, Erik A" sort="Maus, Erik A" uniqKey="Maus E" first="Erik A" last="Maus">Erik A. Maus</name>
<name sortKey="Sevick Muraca, Eva M" sort="Sevick Muraca, Eva M" uniqKey="Sevick Muraca E" first="Eva M" last="Sevick-Muraca">Eva M. Sevick-Muraca</name>
<name sortKey="Smith, Latisha A" sort="Smith, Latisha A" uniqKey="Smith L" first="Latisha A" last="Smith">Latisha A. Smith</name>
<name sortKey="Smith, Latisha A" sort="Smith, Latisha A" uniqKey="Smith L" first="Latisha A" last="Smith">Latisha A. Smith</name>
<name sortKey="Tan, I Chih" sort="Tan, I Chih" uniqKey="Tan I" first="I-Chih" last="Tan">I-Chih Tan</name>
</country>
</tree>
</affiliations>
</record>
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