Role of paclitaxel and platinum-based adjuvant chemotherapy in high-risk penile cancer
Identifieur interne : 002729 ( Pmc/Checkpoint ); précédent : 002728; suivant : 002730Role of paclitaxel and platinum-based adjuvant chemotherapy in high-risk penile cancer
Auteurs : Vanita Noronha [Inde] ; Vijay Patil [Inde] ; Vikas Ostwal [Inde] ; Hemant Tongaonkar [Inde] ; Ganesh Bakshi [Inde] ; Kumar Prabhash [Inde]Source :
- Urology Annals [ 0974-7796 ] ; 2012.
Abstract
To study the efficacy and safety of paclitaxel and platinum doublet chemotherapy in penile cancer patients with high-risk features of local failure.
Retrospective analysis was done of patients with 19 carcinoma of the penis who were offered adjuvant chemotherapy with paclitaxel and platinum combination. The data regarding the surgical details, high-risk features for which chemotherapy was offered, chemotherapy toxicity details (in accordance with CTCAE vs 3), failure pattern, and survival data were noted. SPSS version 16 was used for statistical analysis. Descriptive and Kaplan–Meier survival analysis was performed.
Median age of patients was 48 years. Fifteen patients received paclitaxel in combination with cisplatin and four received paclitaxel with carboplatin in view of their low serum creatinine clearance. The treatment was completed by 12 patients (63.2%). Of 79 planned cycles, 50 were taken. The treatment was well tolerated with grade 3-4 gastrointestinal toxicity was seen in 1 patient, grade 3 neurological toxicity in one and grade 5 neutropenia in one patient. Treatment related death occured in one patient. The median follow-up was 15.33 months and 6 loco-regional relapsed had taken place. The estimated median DFS was 16.2 months and the estimated median OS was not reached. The estimated DFS for treatment completed patients was 23.13 months as against 2.16 months for patients not completing treatment.
The platinum and taxane doublet chemotherapy was found to be safe and effective.
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DOI: 10.4103/0974-7796.102659
PubMed: 23248520
PubMed Central: 3519105
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cancer</title><author><name sortKey="Noronha, Vanita" sort="Noronha, Vanita" uniqKey="Noronha V" first="Vanita" last="Noronha">Vanita Noronha</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Medical Oncology, Tata Memorial Hospital, Mumbai, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Medical Oncology, Tata Memorial Hospital, Mumbai</wicri:regionArea><wicri:noRegion>Mumbai</wicri:noRegion></affiliation></author><author><name sortKey="Patil, Vijay" sort="Patil, Vijay" uniqKey="Patil V" first="Vijay" last="Patil">Vijay Patil</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Medical Oncology, Tata Memorial Hospital, Mumbai, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Medical Oncology, Tata Memorial Hospital, Mumbai</wicri:regionArea><wicri:noRegion>Mumbai</wicri:noRegion></affiliation></author><author><name sortKey="Ostwal, Vikas" sort="Ostwal, Vikas" uniqKey="Ostwal V" first="Vikas" last="Ostwal">Vikas Ostwal</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Medical Oncology, Tata Memorial Hospital, Mumbai, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Medical Oncology, Tata Memorial Hospital, Mumbai</wicri:regionArea><wicri:noRegion>Mumbai</wicri:noRegion></affiliation></author><author><name sortKey="Tongaonkar, Hemant" sort="Tongaonkar, Hemant" uniqKey="Tongaonkar H" first="Hemant" last="Tongaonkar">Hemant Tongaonkar</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Medical Oncology, Tata Memorial Hospital, Mumbai, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Medical Oncology, Tata Memorial Hospital, Mumbai</wicri:regionArea><wicri:noRegion>Mumbai</wicri:noRegion></affiliation></author><author><name sortKey="Bakshi, Ganesh" sort="Bakshi, Ganesh" uniqKey="Bakshi G" first="Ganesh" last="Bakshi">Ganesh Bakshi</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Medical Oncology, Tata Memorial Hospital, Mumbai, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Medical Oncology, Tata Memorial Hospital, Mumbai</wicri:regionArea><wicri:noRegion>Mumbai</wicri:noRegion></affiliation></author><author><name sortKey="Prabhash, Kumar" sort="Prabhash, Kumar" uniqKey="Prabhash K" first="Kumar" last="Prabhash">Kumar Prabhash</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Medical Oncology, Tata Memorial Hospital, Mumbai, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Medical Oncology, Tata Memorial Hospital, Mumbai</wicri:regionArea><wicri:noRegion>Mumbai</wicri:noRegion></affiliation></author></analytic><series><title level="j">Urology Annals</title><idno type="ISSN">0974-7796</idno><idno type="eISSN">0974-7834</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="st1"><title>Aim:</title><p>To study the efficacy and safety of paclitaxel and platinum doublet chemotherapy in penile cancer patients with high-risk features of local failure.</p></sec><sec id="st2"><title>Materials and Methods:</title><p>Retrospective analysis was done of patients with 19 carcinoma of the penis who were offered adjuvant chemotherapy with paclitaxel and platinum combination. The data regarding the surgical details, high-risk features for which chemotherapy was offered, chemotherapy toxicity details (in accordance with CTCAE vs 3), failure pattern, and survival data were noted. SPSS version 16 was used for statistical analysis. Descriptive and Kaplan–Meier survival analysis was performed.</p></sec><sec id="st3"><title>Results:</title><p>Median age of patients was 48 years. Fifteen patients received paclitaxel in combination with cisplatin and four received paclitaxel with carboplatin in view of their low serum creatinine clearance. The treatment was completed by 12 patients (63.2%). Of 79 planned cycles, 50 were taken. The treatment was well tolerated with grade 3-4 gastrointestinal toxicity was seen in 1 patient, grade 3 neurological toxicity in one and grade 5 neutropenia in one patient. Treatment related death occured in one patient. The median follow-up was 15.33 months and 6 loco-regional relapsed had taken place. The estimated median DFS was 16.2 months and the estimated median OS was not reached. The estimated DFS for treatment completed patients was 23.13 months as against 2.16 months for patients not completing treatment.</p></sec><sec id="st4"><title>Conclusion:</title><p>The platinum and taxane doublet chemotherapy was found to be safe and effective.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Barnholtz Sloan, Js" uniqKey="Barnholtz Sloan J">JS Barnholtz-Sloan</name></author><author><name sortKey="Maldonado, Jl" uniqKey="Maldonado J">JL Maldonado</name></author><author><name sortKey="Pow Sang, J" uniqKey="Pow Sang J">J Pow-sang</name></author><author><name sortKey="Giuliano, Ar" uniqKey="Giuliano A">AR Giuliano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Misra, S" uniqKey="Misra S">S Misra</name></author><author><name sortKey="Chaturvedi, A" uniqKey="Chaturvedi A">A Chaturvedi</name></author><author><name sortKey="Misra, Nc" uniqKey="Misra N">NC Misra</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ficarra, V" uniqKey="Ficarra V">V Ficarra</name></author><author><name sortKey="Akduman, B" uniqKey="Akduman B">B Akduman</name></author><author><name sortKey="Bouchot, O" uniqKey="Bouchot O">O Bouchot</name></author><author><name sortKey="Palou, J" uniqKey="Palou J">J Palou</name></author><author><name sortKey="Tobias Machado, M" uniqKey="Tobias Machado M">M Tobias-Machado</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Novara, G" uniqKey="Novara G">G Novara</name></author><author><name sortKey="Galfano, A" uniqKey="Galfano A">A Galfano</name></author><author><name sortKey="De Marco, V" uniqKey="De Marco V">V De Marco</name></author><author><name sortKey="Artibani, W" uniqKey="Artibani W">W Artibani</name></author><author><name sortKey="Ficarra, V" uniqKey="Ficarra V">V Ficarra</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ravi, R" uniqKey="Ravi R">R Ravi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pizzocaro, G" uniqKey="Pizzocaro G">G Pizzocaro</name></author><author><name sortKey="Algaba, F" uniqKey="Algaba F">F Algaba</name></author><author><name sortKey="Horenblas, S" uniqKey="Horenblas S">S Horenblas</name></author><author><name sortKey="Solsona, E" uniqKey="Solsona E">E Solsona</name></author><author><name sortKey="Tana, S" uniqKey="Tana S">S Tana</name></author><author><name sortKey="Van Der Poel, H" uniqKey="Van Der Poel H">H Van Der Poel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hakenberg, Ow" uniqKey="Hakenberg O">OW Hakenberg</name></author><author><name sortKey="Nippgen, Jb" uniqKey="Nippgen J">JB Nippgen</name></author><author><name sortKey="Froehner, M" uniqKey="Froehner M">M Froehner</name></author><author><name sortKey="Zastrow, S" uniqKey="Zastrow S">S Zastrow</name></author><author><name sortKey="Wirth, Mp" uniqKey="Wirth M">MP Wirth</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pizzocaro, G" uniqKey="Pizzocaro G">G Pizzocaro</name></author><author><name sortKey="Piva, L" uniqKey="Piva L">L Piva</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Protzel, C" uniqKey="Protzel C">C Protzel</name></author><author><name sortKey="Ruppin, S" uniqKey="Ruppin S">S Ruppin</name></author><author><name sortKey="Milerski, S" uniqKey="Milerski S">S Milerski</name></author><author><name sortKey="Klebingat, K" uniqKey="Klebingat K">K Klebingat</name></author><author><name sortKey="Hakenberg, Ow" uniqKey="Hakenberg O">OW Hakenberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Di Lorenzo, G" uniqKey="Di Lorenzo G">G Di Lorenzo</name></author><author><name sortKey="Carteni, G" uniqKey="Carteni G">G Cartenì</name></author><author><name sortKey="Autorino, R" uniqKey="Autorino R">R Autorino</name></author><author><name sortKey="Gonnella, A" uniqKey="Gonnella A">A Gonnella</name></author><author><name sortKey="Perdona, S" uniqKey="Perdona S">S Perdonà</name></author><author><name sortKey="Ferro, M" uniqKey="Ferro M">M Ferro</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Posner, M" uniqKey="Posner M">M Posner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lont, Ap" uniqKey="Lont A">AP Lont</name></author><author><name sortKey="Kroon, Bk" uniqKey="Kroon B">BK Kroon</name></author><author><name sortKey="Gallee, Mp" uniqKey="Gallee M">MP Gallee</name></author><author><name sortKey="Van Tinteren, H" uniqKey="Van Tinteren H">H van Tinteren</name></author><author><name sortKey="Moonen, Lm" uniqKey="Moonen L">LM Moonen</name></author><author><name sortKey="Horenblas, S" uniqKey="Horenblas S">S Horenblas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pandey, D" 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Urol Ann</journal-id><journal-id journal-id-type="iso-abbrev">Urol Ann</journal-id><journal-id journal-id-type="publisher-id">UA</journal-id><journal-title-group><journal-title>Urology Annals</journal-title></journal-title-group><issn pub-type="ppub">0974-7796</issn><issn pub-type="epub">0974-7834</issn><publisher><publisher-name>Medknow Publications & Media Pvt Ltd</publisher-name><publisher-loc>India</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">23248520</article-id><article-id pub-id-type="pmc">3519105</article-id><article-id pub-id-type="publisher-id">UA-4-150</article-id><article-id pub-id-type="doi">10.4103/0974-7796.102659</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject></subj-group></article-categories><title-group><article-title>Role of paclitaxel and platinum-based adjuvant chemotherapy in high-risk penile cancer</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Noronha</surname><given-names>Vanita</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Patil</surname><given-names>Vijay</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Ostwal</surname><given-names>Vikas</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Tongaonkar</surname><given-names>Hemant</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Bakshi</surname><given-names>Ganesh</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Prabhash</surname><given-names>Kumar</given-names></name><xref ref-type="aff" rid="aff1"></xref><xref ref-type="corresp" rid="cor1"></xref></contrib></contrib-group><aff id="aff1">Department of Medical Oncology, Tata Memorial Hospital, Mumbai, India</aff><author-notes><corresp id="cor1"><bold>Address for correspondence:</bold> Dr. Kumar Prabhash, Department of Medical Oncology, Tata Memorial Hospital, Parel, Mumbai - 400 012, India. E-mail: <email xlink:href="prabhash1@gmail.com">prabhash1@gmail.com</email></corresp></author-notes><pub-date pub-type="ppub"><season>Sep-Dec</season><year>2012</year></pub-date><volume>4</volume><issue>3</issue><fpage>150</fpage><lpage>153</lpage><history><date date-type="received"><day>13</day><month>6</month><year>2011</year></date><date date-type="accepted"><day>20</day><month>8</month><year>2011</year></date></history><permissions><copyright-statement>Copyright: © Urology Annals</copyright-statement><copyright-year>2012</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc-sa/3.0"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><abstract><sec id="st1"><title>Aim:</title><p>To study the efficacy and safety of paclitaxel and platinum doublet chemotherapy in penile cancer patients with high-risk features of local failure.</p></sec><sec id="st2"><title>Materials and Methods:</title><p>Retrospective analysis was done of patients with 19 carcinoma of the penis who were offered adjuvant chemotherapy with paclitaxel and platinum combination. The data regarding the surgical details, high-risk features for which chemotherapy was offered, chemotherapy toxicity details (in accordance with CTCAE vs 3), failure pattern, and survival data were noted. SPSS version 16 was used for statistical analysis. Descriptive and Kaplan–Meier survival analysis was performed.</p></sec><sec id="st3"><title>Results:</title><p>Median age of patients was 48 years. Fifteen patients received paclitaxel in combination with cisplatin and four received paclitaxel with carboplatin in view of their low serum creatinine clearance. The treatment was completed by 12 patients (63.2%). Of 79 planned cycles, 50 were taken. The treatment was well tolerated with grade 3-4 gastrointestinal toxicity was seen in 1 patient, grade 3 neurological toxicity in one and grade 5 neutropenia in one patient. Treatment related death occured in one patient. The median follow-up was 15.33 months and 6 loco-regional relapsed had taken place. The estimated median DFS was 16.2 months and the estimated median OS was not reached. The estimated DFS for treatment completed patients was 23.13 months as against 2.16 months for patients not completing treatment.</p></sec><sec id="st4"><title>Conclusion:</title><p>The platinum and taxane doublet chemotherapy was found to be safe and effective.</p></sec></abstract><kwd-group><kwd>Adjuvant chemotherapy</kwd><kwd>carcinoma of the penis</kwd><kwd>platinum</kwd></kwd-group></article-meta></front></pmc><affiliations><list><country><li>Inde</li></country></list><tree><country name="Inde"><noRegion><name sortKey="Noronha, Vanita" sort="Noronha, Vanita" uniqKey="Noronha V" first="Vanita" last="Noronha">Vanita Noronha</name></noRegion><name sortKey="Bakshi, Ganesh" sort="Bakshi, Ganesh" uniqKey="Bakshi G" first="Ganesh" last="Bakshi">Ganesh Bakshi</name><name sortKey="Ostwal, Vikas" sort="Ostwal, Vikas" uniqKey="Ostwal V" first="Vikas" last="Ostwal">Vikas Ostwal</name><name sortKey="Patil, Vijay" sort="Patil, Vijay" uniqKey="Patil V" first="Vijay" last="Patil">Vijay Patil</name><name sortKey="Prabhash, Kumar" sort="Prabhash, Kumar" uniqKey="Prabhash K" first="Kumar" last="Prabhash">Kumar Prabhash</name><name sortKey="Tongaonkar, Hemant" sort="Tongaonkar, Hemant" uniqKey="Tongaonkar H" first="Hemant" last="Tongaonkar">Hemant Tongaonkar</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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