Role of vascular endothelial growth factor as a tumour marker in osteosarcoma: a prospective study
Identifieur interne : 002728 ( Pmc/Checkpoint ); précédent : 002727; suivant : 002729Role of vascular endothelial growth factor as a tumour marker in osteosarcoma: a prospective study
Auteurs : Shishir Rastogi [Inde] ; Ramakant Kumar [Inde] ; Sukesh Rao Sankineani [Inde] ; Kanniraj Marimuthu [Inde] ; Laxman Rijal [Inde] ; Shyam Prakash [Inde] ; Divesh Jalan [Inde] ; Shah Alam Khan [Inde] ; Mehar C. Sharma [Inde]Source :
- International Orthopaedics [ 0341-2695 ] ; 2012.
Abstract
A prospective study was undertaken to evaluate the diagnostic and prognostic significance of serum levels of vascular endothelial growth factor (VEGF) in patients with primary localised osteosarcoma.
Serum VEGF levels were measured by an enzyme-linked immunosorbent assay (ELISA) in blood samples collected prechemotherapy, postchemotherapy, and postsurgery in 40 patients with histologically proven primary osteosarcoma. Comparison was made between serum VEGF level of healthy controls (
No significant relationship was observed between serum VEGF levels and age, gender, tumour size, local recurrence or histopathological subtypes of osteosarcoma. We observed significantly raised mean serum VEGF in patient sera compared with healthy controls (
Serum VEGF levels might prove to be of diagnostic, predictive and prognostic value in patients with primary osteosarcoma, although further studies with larger sample size and longer follow-up is needed to support the hypothesis.
Url:
DOI: 10.1007/s00264-012-1663-x
PubMed: 23015149
PubMed Central: 3479274
Affiliations:
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Sharma</name><affiliation wicri:level="1"><nlm:aff id="Aff3">Department of Pathology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 29 India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Pathology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi</wicri:regionArea><wicri:noRegion>New Delhi</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23015149</idno><idno type="pmc">3479274</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479274</idno><idno type="RBID">PMC:3479274</idno><idno type="doi">10.1007/s00264-012-1663-x</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">000B53</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000B53</idno><idno type="wicri:Area/Pmc/Curation">000B52</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000B52</idno><idno type="wicri:Area/Pmc/Checkpoint">002728</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002728</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Role of vascular endothelial growth factor as a tumour marker in osteosarcoma: a prospective study</title><author><name sortKey="Rastogi, Shishir" sort="Rastogi, Shishir" uniqKey="Rastogi S" first="Shishir" last="Rastogi">Shishir Rastogi</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Department of Orthopaedics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 29 India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Orthopaedics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi</wicri:regionArea><wicri:noRegion>New Delhi</wicri:noRegion></affiliation></author><author><name sortKey="Kumar, Ramakant" sort="Kumar, Ramakant" uniqKey="Kumar R" first="Ramakant" last="Kumar">Ramakant Kumar</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Department of Orthopaedics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 29 India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Orthopaedics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi</wicri:regionArea><wicri:noRegion>New Delhi</wicri:noRegion></affiliation></author><author><name sortKey="Sankineani, Sukesh Rao" sort="Sankineani, Sukesh Rao" uniqKey="Sankineani S" first="Sukesh Rao" last="Sankineani">Sukesh Rao Sankineani</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Department of Orthopaedics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 29 India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Orthopaedics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi</wicri:regionArea><wicri:noRegion>New Delhi</wicri:noRegion></affiliation></author><author><name sortKey="Marimuthu, Kanniraj" sort="Marimuthu, Kanniraj" uniqKey="Marimuthu K" first="Kanniraj" last="Marimuthu">Kanniraj Marimuthu</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Department of Orthopaedics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 29 India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Orthopaedics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi</wicri:regionArea><wicri:noRegion>New Delhi</wicri:noRegion></affiliation></author><author><name sortKey="Rijal, Laxman" sort="Rijal, Laxman" uniqKey="Rijal L" first="Laxman" last="Rijal">Laxman Rijal</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Department of Orthopaedics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 29 India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Orthopaedics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi</wicri:regionArea><wicri:noRegion>New Delhi</wicri:noRegion></affiliation></author><author><name sortKey="Prakash, Shyam" sort="Prakash, Shyam" uniqKey="Prakash S" first="Shyam" last="Prakash">Shyam Prakash</name><affiliation wicri:level="1"><nlm:aff id="Aff2">Human Nutrition Unit, Department of Gastroenterology, AIIMS, Ansari Nagar, New Delhi, 29 India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Human Nutrition Unit, Department of Gastroenterology, AIIMS, Ansari Nagar, New Delhi</wicri:regionArea><wicri:noRegion>New Delhi</wicri:noRegion></affiliation></author><author><name sortKey="Jalan, Divesh" sort="Jalan, Divesh" uniqKey="Jalan D" first="Divesh" last="Jalan">Divesh Jalan</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Department of Orthopaedics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 29 India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Orthopaedics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi</wicri:regionArea><wicri:noRegion>New Delhi</wicri:noRegion></affiliation></author><author><name sortKey="Khan, Shah Alam" sort="Khan, Shah Alam" uniqKey="Khan S" first="Shah Alam" last="Khan">Shah Alam Khan</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Department of Orthopaedics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 29 India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Orthopaedics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi</wicri:regionArea><wicri:noRegion>New Delhi</wicri:noRegion></affiliation></author><author><name sortKey="Sharma, Mehar C" sort="Sharma, Mehar C" uniqKey="Sharma M" first="Mehar C." last="Sharma">Mehar C. Sharma</name><affiliation wicri:level="1"><nlm:aff id="Aff3">Department of Pathology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 29 India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Pathology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi</wicri:regionArea><wicri:noRegion>New Delhi</wicri:noRegion></affiliation></author></analytic><series><title level="j">International Orthopaedics</title><idno type="ISSN">0341-2695</idno><idno type="eISSN">1432-5195</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Purpose</title><p>A prospective study was undertaken to evaluate the diagnostic and prognostic significance of serum levels of vascular endothelial growth factor (VEGF) in patients with primary localised osteosarcoma.</p></sec><sec><title>Methods</title><p>Serum VEGF levels were measured by an enzyme-linked immunosorbent assay (ELISA) in blood samples collected prechemotherapy, postchemotherapy, and postsurgery in 40 patients with histologically proven primary osteosarcoma. Comparison was made between serum VEGF level of healthy controls (<italic>n</italic> = 10) and prechemotherapy patient sera to evaluate its diagnostic potential. Serum VEGF levels of patients with and without metastasis were compared. Immunohistochemical staining was done to establish the correlation between serum and tissue VEGF expression. The Kaplan–Meier curve was used for survival analysis</p></sec><sec><title>Results</title><p>No significant relationship was observed between serum VEGF levels and age, gender, tumour size, local recurrence or histopathological subtypes of osteosarcoma. We observed significantly raised mean serum VEGF in patient sera compared with healthy controls (<italic>p</italic> = 0.001). Significant fall in mean serum VEGF level was observed following chemotherapy (<italic>p</italic> = 0.001). Patients who developed metastases had significantly higher serum VEGF levels compared with the nonmetastatic group (<italic>P</italic> = 0.001). Serum VEGF levels correlated well with VEGF expression in tissues.</p></sec><sec><title>Conclusion</title><p>Serum VEGF levels might prove to be of diagnostic, predictive and prognostic value in patients with primary osteosarcoma, although further studies with larger sample size and longer follow-up is needed to support the hypothesis.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Int Orthop</journal-id><journal-id journal-id-type="iso-abbrev">Int Orthop</journal-id><journal-title-group><journal-title>International Orthopaedics</journal-title></journal-title-group><issn pub-type="ppub">0341-2695</issn><issn pub-type="epub">1432-5195</issn><publisher><publisher-name>Springer-Verlag</publisher-name><publisher-loc>Berlin/Heidelberg</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">23015149</article-id><article-id pub-id-type="pmc">3479274</article-id><article-id pub-id-type="publisher-id">1663</article-id><article-id pub-id-type="doi">10.1007/s00264-012-1663-x</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Paper</subject></subj-group></article-categories><title-group><article-title>Role of vascular endothelial growth factor as a tumour marker in osteosarcoma: a prospective study</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Rastogi</surname><given-names>Shishir</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Kumar</surname><given-names>Ramakant</given-names></name><address><phone>+91-9013956902</phone><email>ramakantaiims2007@gmail.com</email></address><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Sankineani</surname><given-names>Sukesh Rao</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Marimuthu</surname><given-names>Kanniraj</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Rijal</surname><given-names>Laxman</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Prakash</surname><given-names>Shyam</given-names></name><xref ref-type="aff" rid="Aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Jalan</surname><given-names>Divesh</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Khan</surname><given-names>Shah Alam</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Sharma</surname><given-names>Mehar C.</given-names></name><xref ref-type="aff" rid="Aff3">3</xref></contrib><aff id="Aff1"><label>1</label>Department of Orthopaedics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 29 India</aff><aff id="Aff2"><label>2</label>Human Nutrition Unit, Department of Gastroenterology, AIIMS, Ansari Nagar, New Delhi, 29 India</aff><aff id="Aff3"><label>3</label>Department of Pathology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 29 India</aff></contrib-group><pub-date pub-type="epub"><day>27</day><month>9</month><year>2012</year></pub-date><pub-date pub-type="ppub"><month>11</month><year>2012</year></pub-date><volume>36</volume><issue>11</issue><fpage>2315</fpage><lpage>2321</lpage><history><date date-type="received"><day>30</day><month>6</month><year>2012</year></date><date date-type="accepted"><day>6</day><month>9</month><year>2012</year></date></history><permissions><copyright-statement>© Springer-Verlag 2012</copyright-statement></permissions><abstract id="Abs1"><sec><title>Purpose</title><p>A prospective study was undertaken to evaluate the diagnostic and prognostic significance of serum levels of vascular endothelial growth factor (VEGF) in patients with primary localised osteosarcoma.</p></sec><sec><title>Methods</title><p>Serum VEGF levels were measured by an enzyme-linked immunosorbent assay (ELISA) in blood samples collected prechemotherapy, postchemotherapy, and postsurgery in 40 patients with histologically proven primary osteosarcoma. Comparison was made between serum VEGF level of healthy controls (<italic>n</italic> = 10) and prechemotherapy patient sera to evaluate its diagnostic potential. Serum VEGF levels of patients with and without metastasis were compared. Immunohistochemical staining was done to establish the correlation between serum and tissue VEGF expression. The Kaplan–Meier curve was used for survival analysis</p></sec><sec><title>Results</title><p>No significant relationship was observed between serum VEGF levels and age, gender, tumour size, local recurrence or histopathological subtypes of osteosarcoma. We observed significantly raised mean serum VEGF in patient sera compared with healthy controls (<italic>p</italic> = 0.001). Significant fall in mean serum VEGF level was observed following chemotherapy (<italic>p</italic> = 0.001). Patients who developed metastases had significantly higher serum VEGF levels compared with the nonmetastatic group (<italic>P</italic> = 0.001). Serum VEGF levels correlated well with VEGF expression in tissues.</p></sec><sec><title>Conclusion</title><p>Serum VEGF levels might prove to be of diagnostic, predictive and prognostic value in patients with primary osteosarcoma, although further studies with larger sample size and longer follow-up is needed to support the hypothesis.</p></sec></abstract><custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name><meta-value>© Springer-Verlag Berlin Heidelberg 2012</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc><affiliations><list><country><li>Inde</li></country></list><tree><country name="Inde"><noRegion><name sortKey="Rastogi, Shishir" sort="Rastogi, Shishir" uniqKey="Rastogi S" first="Shishir" last="Rastogi">Shishir Rastogi</name></noRegion><name sortKey="Jalan, Divesh" sort="Jalan, Divesh" uniqKey="Jalan D" first="Divesh" last="Jalan">Divesh Jalan</name><name sortKey="Khan, Shah Alam" sort="Khan, Shah Alam" uniqKey="Khan S" first="Shah Alam" last="Khan">Shah Alam Khan</name><name sortKey="Kumar, Ramakant" sort="Kumar, Ramakant" uniqKey="Kumar R" first="Ramakant" last="Kumar">Ramakant Kumar</name><name sortKey="Marimuthu, Kanniraj" sort="Marimuthu, Kanniraj" uniqKey="Marimuthu K" first="Kanniraj" last="Marimuthu">Kanniraj Marimuthu</name><name sortKey="Prakash, Shyam" sort="Prakash, Shyam" uniqKey="Prakash S" first="Shyam" last="Prakash">Shyam Prakash</name><name sortKey="Rijal, Laxman" sort="Rijal, Laxman" uniqKey="Rijal L" first="Laxman" last="Rijal">Laxman Rijal</name><name sortKey="Sankineani, Sukesh Rao" sort="Sankineani, Sukesh Rao" uniqKey="Sankineani S" first="Sukesh Rao" last="Sankineani">Sukesh Rao Sankineani</name><name sortKey="Sharma, Mehar C" sort="Sharma, Mehar C" uniqKey="Sharma M" first="Mehar C." last="Sharma">Mehar C. 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