Lymphatic filariasis: Perspectives on lymphatic remodeling and contractile dysfunction in filarial disease pathogenesis
Identifieur interne : 002191 ( Pmc/Checkpoint ); précédent : 002190; suivant : 002192Lymphatic filariasis: Perspectives on lymphatic remodeling and contractile dysfunction in filarial disease pathogenesis
Auteurs : Sanjukta Chakraborty [États-Unis] ; Manokaran Gurusamy [Inde] ; David C. Zawieja [États-Unis] ; Mariappan Muthuchamy [États-Unis]Source :
- Microcirculation (New York, N.Y. : 1994) [ 1073-9688 ] ; 2013.
Abstract
Lymphatic filariasis, one of the most debilitating diseases associated with the lymphatic system, affects over a hundred million people worldwide and manifests itself in a variety of severe clinical pathologies. The filarial parasites specifically target the lymphatics and impair lymph flow, which is critical for the normal functions of the lymphatic system in maintenance of body fluid balance and physiological interstitial fluid transport. The resultant contractile dysfunction of the lymphatics causes fluid accumulation and lymphedema, one of the major pathologies associated with filarial infection. In this review, we take a closer look at the contractile mechanisms of the lymphatics, its altered functions and remodeling during an inflammatory state and how it relates to the severe pathogenesis underlying a filarial infection. We further elaborate on the complex host parasite interactions, and molecular mechanisms contributing to the disease pathogenesis. The overall emphasis is on elucidating some of the emerging concepts and new directions that aim to harness the process of lymphangiogenesis or enhance contractility in a dysfunctional lymphatics, thereby restoring the fluid imbalance and mitigating the pathological conditions of lymphatic filariasis.
Url:
DOI: 10.1111/micc.12031
PubMed: 23237232
PubMed Central: 3613430
Affiliations:
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Zawieja</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Systems Biology and Translational Medicine, Texas A&M Health Science Center College of Medicine, College Station/Temple, Texas</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Department of Systems Biology and Translational Medicine, Texas A&M Health Science Center College of Medicine, College Station/Temple</wicri:cityArea></affiliation></author><author><name sortKey="Muthuchamy, Mariappan" sort="Muthuchamy, Mariappan" uniqKey="Muthuchamy M" first="Mariappan" last="Muthuchamy">Mariappan Muthuchamy</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Systems Biology and Translational Medicine, Texas A&M Health Science Center College of Medicine, College Station/Temple, Texas</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Department of Systems Biology and Translational Medicine, Texas A&M Health Science Center College of Medicine, College Station/Temple</wicri:cityArea></affiliation></author></analytic><series><title level="j">Microcirculation (New York, N.Y. : 1994)</title><idno type="ISSN">1073-9688</idno><idno type="eISSN">1549-8719</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Lymphatic filariasis, one of the most debilitating diseases associated with the lymphatic system, affects over a hundred million people worldwide and manifests itself in a variety of severe clinical pathologies. The filarial parasites specifically target the lymphatics and impair lymph flow, which is critical for the normal functions of the lymphatic system in maintenance of body fluid balance and physiological interstitial fluid transport. The resultant contractile dysfunction of the lymphatics causes fluid accumulation and lymphedema, one of the major pathologies associated with filarial infection. In this review, we take a closer look at the contractile mechanisms of the lymphatics, its altered functions and remodeling during an inflammatory state and how it relates to the severe pathogenesis underlying a filarial infection. We further elaborate on the complex host parasite interactions, and molecular mechanisms contributing to the disease pathogenesis. The overall emphasis is on elucidating some of the emerging concepts and new directions that aim to harness the process of lymphangiogenesis or enhance contractility in a dysfunctional lymphatics, thereby restoring the fluid imbalance and mitigating the pathological conditions of lymphatic filariasis.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
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<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9434935</journal-id><journal-id journal-id-type="pubmed-jr-id">8801</journal-id><journal-id journal-id-type="nlm-ta">Microcirculation</journal-id><journal-id journal-id-type="iso-abbrev">Microcirculation</journal-id><journal-title-group><journal-title>Microcirculation (New York, N.Y. : 1994)</journal-title></journal-title-group><issn pub-type="ppub">1073-9688</issn><issn pub-type="epub">1549-8719</issn></journal-meta><article-meta><article-id pub-id-type="pmid">23237232</article-id><article-id pub-id-type="pmc">3613430</article-id><article-id pub-id-type="doi">10.1111/micc.12031</article-id><article-id pub-id-type="manuscript">NIHMS428015</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Lymphatic filariasis: Perspectives on lymphatic remodeling and contractile dysfunction in filarial disease pathogenesis</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Chakraborty</surname><given-names>Sanjukta</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Gurusamy</surname><given-names>Manokaran</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Zawieja</surname><given-names>David C.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Muthuchamy</surname><given-names>Mariappan</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref rid="FN1" ref-type="author-notes">*</xref></contrib></contrib-group><aff id="A1"><label>1</label>Department of Systems Biology and Translational Medicine, Texas A&M Health Science Center College of Medicine, College Station/Temple, Texas</aff><aff id="A2"><label>2</label>Apollo Hospitals, Chennai, Tamil Nadu, India</aff><author-notes><corresp id="FN1"><label>*</label>Correspondence: Mariappan Muthuchamy, Department of Systems Biology and Translational Medicine, Texas A&M Health Science Center College of Medicine, 336 Reynolds Medical Building, College Station, TX 77843, Phone: 979-845-7816, Fax: 979-862-4638, <email>marim@tamu.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>14</day><month>12</month><year>2012</year></pub-date><pub-date pub-type="ppub"><month>7</month><year>2013</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>7</month><year>2014</year></pub-date><volume>20</volume><issue>5</issue><fpage>349</fpage><lpage>364</lpage><abstract><p id="P1">Lymphatic filariasis, one of the most debilitating diseases associated with the lymphatic system, affects over a hundred million people worldwide and manifests itself in a variety of severe clinical pathologies. The filarial parasites specifically target the lymphatics and impair lymph flow, which is critical for the normal functions of the lymphatic system in maintenance of body fluid balance and physiological interstitial fluid transport. The resultant contractile dysfunction of the lymphatics causes fluid accumulation and lymphedema, one of the major pathologies associated with filarial infection. In this review, we take a closer look at the contractile mechanisms of the lymphatics, its altered functions and remodeling during an inflammatory state and how it relates to the severe pathogenesis underlying a filarial infection. We further elaborate on the complex host parasite interactions, and molecular mechanisms contributing to the disease pathogenesis. The overall emphasis is on elucidating some of the emerging concepts and new directions that aim to harness the process of lymphangiogenesis or enhance contractility in a dysfunctional lymphatics, thereby restoring the fluid imbalance and mitigating the pathological conditions of lymphatic filariasis.</p></abstract><funding-group><award-group><funding-source country="United States">National Heart, Lung, and Blood Institute : NHLBI</funding-source><award-id>K02 HL086650 || HL</award-id></award-group></funding-group></article-meta></front></pmc><affiliations><list><country><li>Inde</li><li>États-Unis</li></country><region><li>Texas</li></region></list><tree><country name="États-Unis"><region name="Texas"><name sortKey="Chakraborty, Sanjukta" sort="Chakraborty, Sanjukta" uniqKey="Chakraborty S" first="Sanjukta" last="Chakraborty">Sanjukta Chakraborty</name></region><name sortKey="Muthuchamy, Mariappan" sort="Muthuchamy, Mariappan" uniqKey="Muthuchamy M" first="Mariappan" last="Muthuchamy">Mariappan Muthuchamy</name><name sortKey="Zawieja, David C" sort="Zawieja, David C" uniqKey="Zawieja D" first="David C." last="Zawieja">David C. Zawieja</name></country><country name="Inde"><noRegion><name sortKey="Gurusamy, Manokaran" sort="Gurusamy, Manokaran" uniqKey="Gurusamy M" first="Manokaran" last="Gurusamy">Manokaran Gurusamy</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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