Effects of exercise intervention in breast cancer survivors: a meta-analysis of 33 randomized controlled trails
Identifieur interne : 000A13 ( Pmc/Checkpoint ); précédent : 000A12; suivant : 000A14Effects of exercise intervention in breast cancer survivors: a meta-analysis of 33 randomized controlled trails
Auteurs : Guoqing Zhu [République populaire de Chine] ; Xiao Zhang [République populaire de Chine] ; Yulan Wang [République populaire de Chine] ; Huizi Xiong [République populaire de Chine] ; Yinghui Zhao [République populaire de Chine] ; Fenyong Sun [République populaire de Chine]Source :
- OncoTargets and therapy [ 1178-6930 ] ; 2016.
Abstract
Exercise is associated with favorable outcomes in cancer survivors. The purpose of this meta-analysis is to comprehensively summarize the effects of exercise intervention in breast cancer survivors.
A systematic search of PubMed, Elsevier, and Google scholar was conducted up to March 2015. References from relevant meta-analyses and reviews were also checked.
Thirty-three randomized controlled trials were included in this meta-analysis, including 2,659 breast cancer survivors. Compared with the control group, quality of life was significantly improved in exercise intervention group, especially in mental health and general health subscales of short form 36 questionnaire, as well as emotion well-being and social well-being subscales of the Functional Assessment of Cancer Therapy. Besides, exercise alleviated the symptoms of depression and anxiety in the exercise group. Furthermore, exercise was also associated with positive outcomes in body mass index, lean mass, and muscle strength. In addition, the serum concentration of insulin, insulin-like growth factor-II, and insulin-like growth factor binding protein-1 was significantly reduced in exercise intervention group. However, based on the current data of this meta-analysis, there were no significant differences in sleep dysfunction or fatigue between groups.
Our study suggested that exercise intervention was beneficial to breast cancer survivors. Therefore, exercise should be recommended to this patient group.
Url:
DOI: 10.2147/OTT.S97864
PubMed: 27110131
PubMed Central: 4835133
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Effects of exercise intervention in breast cancer survivors: a meta-analysis of 33 randomized controlled trails</title><author><name sortKey="Zhu, Guoqing" sort="Zhu, Guoqing" uniqKey="Zhu G" first="Guoqing" last="Zhu">Guoqing Zhu</name><affiliation wicri:level="1"><nlm:aff id="af1-ott-9-2153">Department of Clinical Laboratory Medicine, Shanghai Tenth People’s Hospital of Tongji University, Shanghai, People’s Republic of China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Clinical Laboratory Medicine, Shanghai Tenth People’s Hospital of Tongji University, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Xiao" sort="Zhang, Xiao" uniqKey="Zhang X" first="Xiao" last="Zhang">Xiao Zhang</name><affiliation wicri:level="1"><nlm:aff id="af1-ott-9-2153">Department of Clinical Laboratory Medicine, Shanghai Tenth People’s Hospital of Tongji University, Shanghai, People’s Republic of China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Clinical Laboratory Medicine, Shanghai Tenth People’s Hospital of Tongji University, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Yulan" sort="Wang, Yulan" uniqKey="Wang Y" first="Yulan" last="Wang">Yulan Wang</name><affiliation wicri:level="1"><nlm:aff id="af1-ott-9-2153">Department of Clinical Laboratory Medicine, Shanghai Tenth People’s Hospital of Tongji University, Shanghai, People’s Republic of China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Clinical Laboratory Medicine, Shanghai Tenth People’s Hospital of Tongji University, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Xiong, Huizi" sort="Xiong, Huizi" uniqKey="Xiong H" first="Huizi" last="Xiong">Huizi Xiong</name><affiliation wicri:level="1"><nlm:aff id="af2-ott-9-2153">Department of Dermatology, Shanghai Tenth People’s Hospital of Tongji University, Shanghai, People’s Republic of China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Dermatology, Shanghai Tenth People’s Hospital of Tongji University, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Zhao, Yinghui" sort="Zhao, Yinghui" uniqKey="Zhao Y" first="Yinghui" last="Zhao">Yinghui Zhao</name><affiliation wicri:level="1"><nlm:aff id="af1-ott-9-2153">Department of Clinical Laboratory Medicine, Shanghai Tenth People’s Hospital of Tongji University, Shanghai, People’s Republic of China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Clinical Laboratory Medicine, Shanghai Tenth People’s Hospital of Tongji University, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Sun, Fenyong" sort="Sun, Fenyong" uniqKey="Sun F" first="Fenyong" last="Sun">Fenyong Sun</name><affiliation wicri:level="1"><nlm:aff id="af1-ott-9-2153">Department of Clinical Laboratory Medicine, Shanghai Tenth People’s Hospital of Tongji University, Shanghai, People’s Republic of China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Clinical Laboratory Medicine, Shanghai Tenth People’s Hospital of Tongji University, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27110131</idno><idno type="pmc">4835133</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835133</idno><idno type="RBID">PMC:4835133</idno><idno type="doi">10.2147/OTT.S97864</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000799</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000799</idno><idno type="wicri:Area/Pmc/Curation">000799</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000799</idno><idno type="wicri:Area/Pmc/Checkpoint">000A13</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000A13</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Effects of exercise intervention in breast cancer survivors: a meta-analysis of 33 randomized controlled trails</title><author><name sortKey="Zhu, Guoqing" sort="Zhu, Guoqing" uniqKey="Zhu G" first="Guoqing" last="Zhu">Guoqing Zhu</name><affiliation wicri:level="1"><nlm:aff id="af1-ott-9-2153">Department of Clinical Laboratory Medicine, Shanghai Tenth People’s Hospital of Tongji University, Shanghai, People’s Republic of China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Clinical Laboratory Medicine, Shanghai Tenth People’s Hospital of Tongji University, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Xiao" sort="Zhang, Xiao" uniqKey="Zhang X" first="Xiao" last="Zhang">Xiao Zhang</name><affiliation wicri:level="1"><nlm:aff id="af1-ott-9-2153">Department of Clinical Laboratory Medicine, Shanghai Tenth People’s Hospital of Tongji University, Shanghai, People’s Republic of China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Clinical Laboratory Medicine, Shanghai Tenth People’s Hospital of Tongji University, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Yulan" sort="Wang, Yulan" uniqKey="Wang Y" first="Yulan" last="Wang">Yulan Wang</name><affiliation wicri:level="1"><nlm:aff id="af1-ott-9-2153">Department of Clinical Laboratory Medicine, Shanghai Tenth People’s Hospital of Tongji University, Shanghai, People’s Republic of China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Clinical Laboratory Medicine, Shanghai Tenth People’s Hospital of Tongji University, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Xiong, Huizi" sort="Xiong, Huizi" uniqKey="Xiong H" first="Huizi" last="Xiong">Huizi Xiong</name><affiliation wicri:level="1"><nlm:aff id="af2-ott-9-2153">Department of Dermatology, Shanghai Tenth People’s Hospital of Tongji University, Shanghai, People’s Republic of China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Dermatology, Shanghai Tenth People’s Hospital of Tongji University, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Zhao, Yinghui" sort="Zhao, Yinghui" uniqKey="Zhao Y" first="Yinghui" last="Zhao">Yinghui Zhao</name><affiliation wicri:level="1"><nlm:aff id="af1-ott-9-2153">Department of Clinical Laboratory Medicine, Shanghai Tenth People’s Hospital of Tongji University, Shanghai, People’s Republic of China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Clinical Laboratory Medicine, Shanghai Tenth People’s Hospital of Tongji University, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Sun, Fenyong" sort="Sun, Fenyong" uniqKey="Sun F" first="Fenyong" last="Sun">Fenyong Sun</name><affiliation wicri:level="1"><nlm:aff id="af1-ott-9-2153">Department of Clinical Laboratory Medicine, Shanghai Tenth People’s Hospital of Tongji University, Shanghai, People’s Republic of China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Clinical Laboratory Medicine, Shanghai Tenth People’s Hospital of Tongji University, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author></analytic><series><title level="j">OncoTargets and therapy</title><idno type="eISSN">1178-6930</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Exercise is associated with favorable outcomes in cancer survivors. The purpose of this meta-analysis is to comprehensively summarize the effects of exercise intervention in breast cancer survivors.</p></sec><sec><title>Methods</title><p>A systematic search of PubMed, Elsevier, and Google scholar was conducted up to March 2015. References from relevant meta-analyses and reviews were also checked.</p></sec><sec><title>Results</title><p>Thirty-three randomized controlled trials were included in this meta-analysis, including 2,659 breast cancer survivors. Compared with the control group, quality of life was significantly improved in exercise intervention group, especially in mental health and general health subscales of short form 36 questionnaire, as well as emotion well-being and social well-being subscales of the Functional Assessment of Cancer Therapy. Besides, exercise alleviated the symptoms of depression and anxiety in the exercise group. Furthermore, exercise was also associated with positive outcomes in body mass index, lean mass, and muscle strength. In addition, the serum concentration of insulin, insulin-like growth factor-II, and insulin-like growth factor binding protein-1 was significantly reduced in exercise intervention group. However, based on the current data of this meta-analysis, there were no significant differences in sleep dysfunction or fatigue between groups.</p></sec><sec><title>Conclusion</title><p>Our study suggested that exercise intervention was beneficial to breast cancer survivors. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Onco Targets Ther</journal-id><journal-id journal-id-type="iso-abbrev">Onco Targets Ther</journal-id><journal-id journal-id-type="publisher-id">OncoTargets and Therapy</journal-id><journal-title-group><journal-title>OncoTargets and therapy</journal-title></journal-title-group><issn pub-type="epub">1178-6930</issn><publisher><publisher-name>Dove Medical Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">27110131</article-id><article-id pub-id-type="pmc">4835133</article-id><article-id pub-id-type="doi">10.2147/OTT.S97864</article-id><article-id pub-id-type="publisher-id">ott-9-2153</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Research</subject></subj-group></article-categories><title-group><article-title>Effects of exercise intervention in breast cancer survivors: a meta-analysis of 33 randomized controlled trails</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Zhu</surname><given-names>Guoqing</given-names></name><xref ref-type="aff" rid="af1-ott-9-2153">1</xref></contrib><contrib contrib-type="author"><name><surname>Zhang</surname><given-names>Xiao</given-names></name><xref ref-type="aff" rid="af1-ott-9-2153">1</xref></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Yulan</given-names></name><xref ref-type="aff" rid="af1-ott-9-2153">1</xref></contrib><contrib contrib-type="author"><name><surname>Xiong</surname><given-names>Huizi</given-names></name><xref ref-type="aff" rid="af2-ott-9-2153">2</xref></contrib><contrib contrib-type="author"><name><surname>Zhao</surname><given-names>Yinghui</given-names></name><xref ref-type="aff" rid="af1-ott-9-2153">1</xref></contrib><contrib contrib-type="author"><name><surname>Sun</surname><given-names>Fenyong</given-names></name><xref ref-type="aff" rid="af1-ott-9-2153">1</xref><xref ref-type="corresp" rid="c1-ott-9-2153"></xref></contrib></contrib-group><aff id="af1-ott-9-2153"><label>1</label>Department of Clinical Laboratory Medicine, Shanghai Tenth People’s Hospital of Tongji University, Shanghai, People’s Republic of China</aff><aff id="af2-ott-9-2153"><label>2</label>Department of Dermatology, Shanghai Tenth People’s Hospital of Tongji University, Shanghai, People’s Republic of China</aff><author-notes><corresp id="c1-ott-9-2153">Correspondence: Fenyong Sun, Department of Clinical Laboratory Medicine, Shanghai Tenth People’s Hospital of Tongji University, No 301 Middle Yanchang Rd, Shanghai, 200072, People’s Republic of China, Tel +86 21 6630 0588, Fax +86 21 6630 0588, Email <email>sunfenyongtongji@126.com</email></corresp></author-notes><pub-date pub-type="collection"><year>2016</year></pub-date><pub-date pub-type="epub"><day>13</day><month>4</month><year>2016</year></pub-date><volume>9</volume><fpage>2153</fpage><lpage>2168</lpage><permissions><copyright-statement>© 2016 Zhu et al. This work is published and licensed by Dove Medical Press Limited</copyright-statement><copyright-year>2016</copyright-year><license><license-p>The full terms of this license are available at <ext-link ext-link-type="uri" xlink:href="https://www.dovepress.com/terms.php">https://www.dovepress.com/terms.php</ext-link> and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc/3.0/">http://creativecommons.org/licenses/by-nc/3.0/</ext-link>). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.</license-p></license></permissions><abstract><sec><title>Background</title><p>Exercise is associated with favorable outcomes in cancer survivors. The purpose of this meta-analysis is to comprehensively summarize the effects of exercise intervention in breast cancer survivors.</p></sec><sec><title>Methods</title><p>A systematic search of PubMed, Elsevier, and Google scholar was conducted up to March 2015. References from relevant meta-analyses and reviews were also checked.</p></sec><sec><title>Results</title><p>Thirty-three randomized controlled trials were included in this meta-analysis, including 2,659 breast cancer survivors. Compared with the control group, quality of life was significantly improved in exercise intervention group, especially in mental health and general health subscales of short form 36 questionnaire, as well as emotion well-being and social well-being subscales of the Functional Assessment of Cancer Therapy. Besides, exercise alleviated the symptoms of depression and anxiety in the exercise group. Furthermore, exercise was also associated with positive outcomes in body mass index, lean mass, and muscle strength. In addition, the serum concentration of insulin, insulin-like growth factor-II, and insulin-like growth factor binding protein-1 was significantly reduced in exercise intervention group. However, based on the current data of this meta-analysis, there were no significant differences in sleep dysfunction or fatigue between groups.</p></sec><sec><title>Conclusion</title><p>Our study suggested that exercise intervention was beneficial to breast cancer survivors. Therefore, exercise should be recommended to this patient group.</p></sec></abstract><kwd-group><title>Keywords</title><kwd>exercise</kwd><kwd>quality of life</kwd><kwd>depression</kwd><kwd>BMI</kwd><kwd>insulin</kwd></kwd-group></article-meta></front><floats-group><fig id="f1-ott-9-2153" position="float"><label>Figure 1</label><caption><p>Flow diagram of study selection.</p><p><bold>Abbreviation:</bold> RCT, randomized controlled trial.</p></caption><graphic xlink:href="ott-9-2153Fig1"></graphic></fig><fig id="f2-ott-9-2153" position="float"><label>Figure 2</label><caption><p>The association between exercise intervention and quality of life in breast cancer survivors.</p><p><bold>Notes:</bold> (<bold>A</bold>) SF-36 mental health, (<bold>B</bold>) SF-36 general health, (<bold>C</bold>) FACT emotion well-being, and (<bold>D</bold>) FACT social well-being.</p><p><bold>Abbreviations:</bold> CI, confidence interval; FACT, Functional Assessment of Cancer Therapy; SD, standard deviation; SF-36, short form 36 questionnaire; <italic>df</italic>, degree of freedom.</p></caption><graphic xlink:href="ott-9-2153Fig2"></graphic></fig><fig id="f3-ott-9-2153" position="float"><label>Figure 3</label><caption><p>The association between exercise intervention and depression and anxiety in breast cancer survivors.</p><p><bold>Notes:</bold> (<bold>A</bold>) Depression and (<bold>B</bold>) anxiety.</p><p><bold>Abbreviations:</bold> CI, confidence interval; SD, standard deviation; <italic>df</italic>, degree of freedom.</p></caption><graphic xlink:href="ott-9-2153Fig3"></graphic></fig><fig id="f4-ott-9-2153" position="float"><label>Figure 4</label><caption><p>The association between exercise intervention and body mass index in breast cancer survivors.</p><p><bold>Abbreviations:</bold> CI, confidence interval; SD, standard deviation; <italic>df</italic>, degree of freedom.</p></caption><graphic xlink:href="ott-9-2153Fig4"></graphic></fig><fig id="f5-ott-9-2153" position="float"><label>Figure 5</label><caption><p>The association between exercise intervention and muscle strength in breast cancer survivors.</p><p><bold>Abbreviations:</bold> CI, confidence interval; SD, standard deviation; <italic>df</italic>, degree of freedom.</p></caption><graphic xlink:href="ott-9-2153Fig5"></graphic></fig><fig id="f6-ott-9-2153" position="float"><label>Figure 6</label><caption><p>The association between exercise intervention and fatigue in breast cancer survivors.</p><p><bold>Notes:</bold> (<bold>A</bold>) Overall effect and (<bold>B</bold>) subgroup analysis based on the type of exercise intervention.</p><p><bold>Abbreviations:</bold> CI, confidence interval; FACIT, Functional Assessment of Chronic Illness Therapy; SD, standard deviation; <italic>df</italic>, degree of freedom.</p></caption><graphic xlink:href="ott-9-2153Fig6"></graphic></fig><fig id="f7-ott-9-2153" position="float"><label>Figure 7</label><caption><p>The association between exercise intervention and insulin and IGFBP-1 in breast cancer survivors.</p><p><bold>Notes:</bold> (<bold>A</bold>) Insulin and (<bold>B</bold>) IGFBP-1.</p><p><bold>Abbreviations:</bold> CI, confidence interval; IFGBP-1, insulin-like growth factor binding protein-1; SD, standard deviation; <italic>df</italic>, degree of freedom.</p></caption><graphic xlink:href="ott-9-2153Fig7"></graphic></fig><table-wrap id="t1-ott-9-2153" position="float"><label>Table 1</label><caption><p>Characteristics of 33 studies included in this meta-analysis</p></caption><table frame="hsides" rules="groups"><thead><tr><th valign="top" align="left" rowspan="1" colspan="1">Year</th><th valign="top" align="left" rowspan="1" colspan="1">Study</th><th valign="top" align="left" rowspan="1" colspan="1">Author</th><th valign="top" align="left" rowspan="1" colspan="1">Mean age (SD)<break></break>Intervention/control</th><th valign="top" align="left" rowspan="1" colspan="1">The exercise type of intervention/control</th><th valign="top" align="left" rowspan="1" colspan="1">Number of subjects in intervention/control groups</th><th valign="top" align="left" rowspan="1" colspan="1">Timing</th><th valign="top" align="left" rowspan="1" colspan="1">Intensity</th><th valign="top" align="left" rowspan="1" colspan="1">Frequency</th><th valign="top" align="left" rowspan="1" colspan="1">Duration</th><th valign="top" align="left" rowspan="1" colspan="1">Outcomes</th></tr></thead><tbody><tr><td valign="top" align="left" rowspan="1" colspan="1">2006</td><td valign="top" align="left" rowspan="1" colspan="1">26</td><td valign="top" align="left" rowspan="1" colspan="1">Basen-Engquist et al</td><td valign="top" align="left" rowspan="1" colspan="1">55.7 (11.1)/54.4 (11.7)</td><td valign="top" align="left" rowspan="1" colspan="1">Lifestyle program/standard care</td><td valign="top" align="left" rowspan="1" colspan="1">35/25</td><td valign="top" align="left" rowspan="1" colspan="1">Posttreatment</td><td valign="top" align="left" rowspan="1" colspan="1">Moderate</td><td valign="top" align="left" rowspan="1" colspan="1">NR</td><td valign="top" align="left" rowspan="1" colspan="1">6 months</td><td valign="top" align="left" rowspan="1" colspan="1">Physical performance, QoL</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">2007</td><td valign="top" align="left" rowspan="1" colspan="1">27</td><td valign="top" align="left" rowspan="1" colspan="1">Battaglini</td><td valign="top" align="left" rowspan="1" colspan="1">56.6 (16)/57.5 (23)</td><td valign="top" align="left" rowspan="1" colspan="1">Cardiovascular, resistance, flexibility/control group</td><td valign="top" align="left" rowspan="1" colspan="1">10/10</td><td valign="top" align="left" rowspan="1" colspan="1">During treatment</td><td valign="top" align="left" rowspan="1" colspan="1">Low-moderate: 40%–60% of predicted maximum exercise capacity</td><td valign="top" align="left" rowspan="1" colspan="1">2 times/week, ≤60 minutes</td><td valign="top" align="left" rowspan="1" colspan="1">21 weeks</td><td valign="top" align="left" rowspan="1" colspan="1">Body composition, muscle strength</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">2014</td><td valign="top" align="left" rowspan="1" colspan="1">28</td><td valign="top" align="left" rowspan="1" colspan="1">Bower et al</td><td valign="top" align="left" rowspan="1" colspan="1">54 (5.4)</td><td valign="top" align="left" rowspan="1" colspan="1">Iyengar yoga/health education</td><td valign="top" align="left" rowspan="1" colspan="1">16/15</td><td valign="top" align="left" rowspan="1" colspan="1">Posttreatment</td><td valign="top" align="left" rowspan="1" colspan="1">NR</td><td valign="top" align="left" rowspan="1" colspan="1">NR</td><td valign="top" align="left" rowspan="1" colspan="1">12 weeks</td><td valign="top" align="left" rowspan="1" colspan="1">Inflammation-related gene expression, circulating markers of proinflammatory cytokine, salivary cortisol</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">2011</td><td valign="top" align="left" rowspan="1" colspan="1">29</td><td valign="top" align="left" rowspan="1" colspan="1">Cantarero-Villanueva et al</td><td valign="top" align="left" rowspan="1" colspan="1">48 (9)/49 (9)</td><td valign="top" align="left" rowspan="1" colspan="1">Aerobic, resistance, neck–shoulder mobility, self-massage/usual care</td><td valign="top" align="left" rowspan="1" colspan="1">38/40</td><td valign="top" align="left" rowspan="1" colspan="1">Posttreatment</td><td valign="top" align="left" rowspan="1" colspan="1">Aerobic: ACSM recommendations; resistance; 75% maximum load and increase</td><td valign="top" align="left" rowspan="1" colspan="1">3 times/week; 90 minutes</td><td valign="top" align="left" rowspan="1" colspan="1">8 weeks</td><td valign="top" align="left" rowspan="1" colspan="1">Fatigue, cortisol, IgA salivary levels, α-amylase activity, cervical–shoulder range of motion</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">2007</td><td valign="top" align="left" rowspan="1" colspan="1">30</td><td valign="top" align="left" rowspan="1" colspan="1">Courneya et al</td><td valign="top" align="left" rowspan="1" colspan="1">49.5/49/49</td><td valign="top" align="left" rowspan="1" colspan="1">Aerobic/resistance/usual care</td><td valign="top" align="left" rowspan="1" colspan="1">82/78/82</td><td valign="top" align="left" rowspan="1" colspan="1">During treatment</td><td valign="top" align="left" rowspan="1" colspan="1">AET: 60%–80% of VO2 max; RET: 60%–70% of their estimated one repetition maximum</td><td valign="top" align="left" rowspan="1" colspan="1">3 times/week</td><td valign="top" align="left" rowspan="1" colspan="1">Mean 17 (9–24) weeks</td><td valign="top" align="left" rowspan="1" colspan="1">QoL, physical fitness, body composition, psychosocial functioning, fatigue</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">2007</td><td valign="top" align="left" rowspan="1" colspan="1">31</td><td valign="top" align="left" rowspan="1" colspan="1">Daley et al</td><td valign="top" align="left" rowspan="1" colspan="1">51.6 (8.8)/50.6 (8.7)/51.1 (8.6)</td><td valign="top" align="left" rowspan="1" colspan="1">Aerobic exercise/exercise–placebo/usual care</td><td valign="top" align="left" rowspan="1" colspan="1">34/46/38</td><td valign="top" align="left" rowspan="1" colspan="1">Posttreatment</td><td valign="top" align="left" rowspan="1" colspan="1">Moderate-intensity (65%–85% of age-adjusted HR maximum and RPE of 12–13)</td><td valign="top" align="left" rowspan="1" colspan="1">3 times/week, 50 minutes</td><td valign="top" align="left" rowspan="1" colspan="1">8 weeks</td><td valign="top" align="left" rowspan="1" colspan="1">QoL, depression, fatigue exercise behavior, aerobic fitness</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">2006</td><td valign="top" align="left" rowspan="1" colspan="1">32</td><td valign="top" align="left" rowspan="1" colspan="1">Drouin et al</td><td valign="top" align="left" rowspan="1" colspan="1">49.4 (7.0)/51.9 (10)</td><td valign="top" align="left" rowspan="1" colspan="1">Walking/placebo stretching</td><td valign="top" align="left" rowspan="1" colspan="1">8/13</td><td valign="top" align="left" rowspan="1" colspan="1">During treatment</td><td valign="top" align="left" rowspan="1" colspan="1">50%–70% of measured maximum HRs</td><td valign="top" align="left" rowspan="1" colspan="1">3–5 times/week, 20–45 minutes</td><td valign="top" align="left" rowspan="1" colspan="1">7 weeks</td><td valign="top" align="left" rowspan="1" colspan="1">Erythrocyte measures: RBC, HCT, HB, peak VO2</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">2009</td><td valign="top" align="left" rowspan="1" colspan="1">33</td><td valign="top" align="left" rowspan="1" colspan="1">Irwin et al</td><td valign="top" align="left" rowspan="1" colspan="1">56.5 (9.5)/55.1 (7.7)</td><td valign="top" align="left" rowspan="1" colspan="1">Walking/usual care</td><td valign="top" align="left" rowspan="1" colspan="1">37/38</td><td valign="top" align="left" rowspan="1" colspan="1">Posttreatment</td><td valign="top" align="left" rowspan="1" colspan="1">Moderate (60%–80% of predicted maximal HR)</td><td valign="top" align="left" rowspan="1" colspan="1">3 times (supervised)<break></break>+2 times (own)/week, 150 minutes</td><td valign="top" align="left" rowspan="1" colspan="1">6 months</td><td valign="top" align="left" rowspan="1" colspan="1">Body composition, physical activity levels</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">2009</td><td valign="top" align="left" rowspan="1" colspan="1">34</td><td valign="top" align="left" rowspan="1" colspan="1">Irwin et al</td><td valign="top" align="left" rowspan="1" colspan="1">56.5 (9.5)/55.1 (7.7)</td><td valign="top" align="left" rowspan="1" colspan="1">Walking/usual care</td><td valign="top" align="left" rowspan="1" colspan="1">37/38</td><td valign="top" align="left" rowspan="1" colspan="1">Posttreatment</td><td valign="top" align="left" rowspan="1" colspan="1">Moderate (60%–80% of predicted maximal HR)</td><td valign="top" align="left" rowspan="1" colspan="1">3 times (supervised)<break></break>+2 times (own)/week, 150 minutes</td><td valign="top" align="left" rowspan="1" colspan="1">6 months</td><td valign="top" align="left" rowspan="1" colspan="1">Insulin, IGF-1, IGFBP-3</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">2011</td><td valign="top" align="left" rowspan="1" colspan="1">35</td><td valign="top" align="left" rowspan="1" colspan="1">Janelsins et al</td><td valign="top" align="left" rowspan="1" colspan="1">54.33 (10.64)/52.7 (6.67)</td><td valign="top" align="left" rowspan="1" colspan="1">Tai Chi Chuan/no exercise control</td><td valign="top" align="left" rowspan="1" colspan="1">9/10</td><td valign="top" align="left" rowspan="1" colspan="1">Posttreatment</td><td valign="top" align="left" rowspan="1" colspan="1">Moderate</td><td valign="top" align="left" rowspan="1" colspan="1">3 times/week, 60 minutes</td><td valign="top" align="left" rowspan="1" colspan="1">12 weeks</td><td valign="top" align="left" rowspan="1" colspan="1">Insulin, insulin-related molecules and cytokines, body composition</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">2008</td><td valign="top" align="left" rowspan="1" colspan="1">36</td><td valign="top" align="left" rowspan="1" colspan="1">Milne et al</td><td valign="top" align="left" rowspan="1" colspan="1">55.2 (8.4)/55.1 (8.0)</td><td valign="top" align="left" rowspan="1" colspan="1">Aerobic, resistance, stretching: immediate/delayed exercise group</td><td valign="top" align="left" rowspan="1" colspan="1">29/29</td><td valign="top" align="left" rowspan="1" colspan="1">Posttreatment</td><td valign="top" align="left" rowspan="1" colspan="1">NR</td><td valign="top" align="left" rowspan="1" colspan="1">3 times/week</td><td valign="top" align="left" rowspan="1" colspan="1">12 weeks</td><td valign="top" align="left" rowspan="1" colspan="1">QoL, fatigue, social physical anxiety, aerobic fitness</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">2007</td><td valign="top" align="left" rowspan="1" colspan="1">37</td><td valign="top" align="left" rowspan="1" colspan="1">Mutrieet et al</td><td valign="top" align="left" rowspan="1" colspan="1">51.3 (10.3)/51.8 (8.7)</td><td valign="top" align="left" rowspan="1" colspan="1">Group exercise program: aerobic, resistance/usual care</td><td valign="top" align="left" rowspan="1" colspan="1">101/102</td><td valign="top" align="left" rowspan="1" colspan="1">During treatment</td><td valign="top" align="left" rowspan="1" colspan="1">Moderate (50%–75% of age adjusted maximum HR)</td><td valign="top" align="left" rowspan="1" colspan="1">3 times/week, 45 minutes</td><td valign="top" align="left" rowspan="1" colspan="1">12 weeks</td><td valign="top" align="left" rowspan="1" colspan="1">QoL, depression, physical activity, shoulder mobility</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">2007</td><td valign="top" align="left" rowspan="1" colspan="1">38</td><td valign="top" align="left" rowspan="1" colspan="1">Nikander et al</td><td valign="top" align="left" rowspan="1" colspan="1">52.5 (6.4)/51.3 (7.3)</td><td valign="top" align="left" rowspan="1" colspan="1">Aerobic exercise/daily activity</td><td valign="top" align="left" rowspan="1" colspan="1">14/14</td><td valign="top" align="left" rowspan="1" colspan="1">Posttreatment</td><td valign="top" align="left" rowspan="1" colspan="1">Vigorous</td><td valign="top" align="left" rowspan="1" colspan="1">3 times/week</td><td valign="top" align="left" rowspan="1" colspan="1">12 weeks</td><td valign="top" align="left" rowspan="1" colspan="1">Feasibility, efficacy, physical performance</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">2009</td><td valign="top" align="left" rowspan="1" colspan="1">39</td><td valign="top" align="left" rowspan="1" colspan="1">Rao et al</td><td valign="top" align="left" rowspan="1" colspan="1">NR</td><td valign="top" align="left" rowspan="1" colspan="1">Yoga/brief supportive therapy</td><td valign="top" align="left" rowspan="1" colspan="1">45/53</td><td valign="top" align="left" rowspan="1" colspan="1">Before treatment</td><td valign="top" align="left" rowspan="1" colspan="1">NR</td><td valign="top" align="left" rowspan="1" colspan="1">Daily/60 minutes</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1">QoL</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">2013</td><td valign="top" align="left" rowspan="1" colspan="1">40</td><td valign="top" align="left" rowspan="1" colspan="1">Rogers et al</td><td valign="top" align="left" rowspan="1" colspan="1">58.0 (6.1)/53.7 (13.9)</td><td valign="top" align="left" rowspan="1" colspan="1">Aerobic, resistance/usual care</td><td valign="top" align="left" rowspan="1" colspan="1">15/13</td><td valign="top" align="left" rowspan="1" colspan="1">Posttreatment</td><td valign="top" align="left" rowspan="1" colspan="1">Moderate</td><td valign="top" align="left" rowspan="1" colspan="1">150 minutes weekly aerobic, 2 sessions/week resistance</td><td valign="top" align="left" rowspan="1" colspan="1">3 months</td><td valign="top" align="left" rowspan="1" colspan="1">Inflammatory-related serum markers, cardiorespiratory fitness, muscle strength, body composition, fatigue, strength, body composition, fatigue, sleep</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">2009</td><td valign="top" align="left" rowspan="1" colspan="1">41</td><td valign="top" align="left" rowspan="1" colspan="1">Rogers et al</td><td valign="top" align="left" rowspan="1" colspan="1">52 (15)/54 (8)</td><td valign="top" align="left" rowspan="1" colspan="1">Walking/usual care</td><td valign="top" align="left" rowspan="1" colspan="1">21/20</td><td valign="top" align="left" rowspan="1" colspan="1">Posttreatment</td><td valign="top" align="left" rowspan="1" colspan="1">Moderate</td><td valign="top" align="left" rowspan="1" colspan="1">150 minutes/week</td><td valign="top" align="left" rowspan="1" colspan="1">12 weeks</td><td valign="top" align="left" rowspan="1" colspan="1">Feasibility, healthy outcome: aerobic fitness, muscle strength, body composition, QoL, sleep</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">2009</td><td valign="top" align="left" rowspan="1" colspan="1">42</td><td valign="top" align="left" rowspan="1" colspan="1">Vadiraja et al</td><td valign="top" align="left" rowspan="1" colspan="1">NR</td><td valign="top" align="left" rowspan="1" colspan="1">Yoga/brief supportive therapy</td><td valign="top" align="left" rowspan="1" colspan="1">45/53</td><td valign="top" align="left" rowspan="1" colspan="1">Before treatment</td><td valign="top" align="left" rowspan="1" colspan="1">NR</td><td valign="top" align="left" rowspan="1" colspan="1">Daily/60 minutes</td><td valign="top" align="left" rowspan="1" colspan="1">NR</td><td valign="top" align="left" rowspan="1" colspan="1">QoL</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">2009</td><td valign="top" align="left" rowspan="1" colspan="1">42</td><td valign="top" align="left" rowspan="1" colspan="1">Vadiraja et al</td><td valign="top" align="left" rowspan="1" colspan="1">NR</td><td valign="top" align="left" rowspan="1" colspan="1">Yoga/brief supportive therapy</td><td valign="top" align="left" rowspan="1" colspan="1">45/53</td><td valign="top" align="left" rowspan="1" colspan="1">Before treatment</td><td valign="top" align="left" rowspan="1" colspan="1">NR</td><td valign="top" align="left" rowspan="1" colspan="1">Daily/60 minutes</td><td valign="top" align="left" rowspan="1" colspan="1">NR</td><td valign="top" align="left" rowspan="1" colspan="1">The total caloric intake, fatigue, body composition, aerobic fitness</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">2008</td><td valign="top" align="left" rowspan="1" colspan="1">43</td><td valign="top" align="left" rowspan="1" colspan="1">Battaglini</td><td valign="top" align="left" rowspan="1" colspan="1">57.5 (23)/56.6 (16)</td><td valign="top" align="left" rowspan="1" colspan="1">Cardiovascular, stretching, resistance/control group</td><td valign="top" align="left" rowspan="1" colspan="1">10/10</td><td valign="top" align="left" rowspan="1" colspan="1">During treatment</td><td valign="top" align="left" rowspan="1" colspan="1">40%–60% of predicted maximum exercise capacity</td><td valign="top" align="left" rowspan="1" colspan="1">2 times/week, ≤60 minutes</td><td valign="top" align="left" rowspan="1" colspan="1">6 months</td><td valign="top" align="left" rowspan="1" colspan="1">Peak oxygen consumption, QoL, fatigue, self-esteem, happiness, body composition</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">2003</td><td valign="top" align="left" rowspan="1" colspan="1">44</td><td valign="top" align="left" rowspan="1" colspan="1">Courneya et al</td><td valign="top" align="left" rowspan="1" colspan="1">59 (5)/58 (6)</td><td valign="top" align="left" rowspan="1" colspan="1">Cycle ergometers/no train</td><td valign="top" align="left" rowspan="1" colspan="1">24/28</td><td valign="top" align="left" rowspan="1" colspan="1">Posttreatment</td><td valign="top" align="left" rowspan="1" colspan="1">70%–75% of maximal oxygen consumption in untrained subjects</td><td valign="top" align="left" rowspan="1" colspan="1">3 times/week, 15–35 minutes</td><td valign="top" align="left" rowspan="1" colspan="1">15 weeks</td><td valign="top" align="left" rowspan="1" colspan="1">QoL, fatigue, ROM of shoulder, pain</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">2008</td><td valign="top" align="left" rowspan="1" colspan="1">45</td><td valign="top" align="left" rowspan="1" colspan="1">Hwang et al</td><td valign="top" align="left" rowspan="1" colspan="1">46.3 (7.5)/46.3 (9.5)</td><td valign="top" align="left" rowspan="1" colspan="1">Stretching, aerobic exercise/self-shoulder stretching</td><td valign="top" align="left" rowspan="1" colspan="1">17/23</td><td valign="top" align="left" rowspan="1" colspan="1">During treatment</td><td valign="top" align="left" rowspan="1" colspan="1">50%–70% of the age-adjusted HR maximum</td><td valign="top" align="left" rowspan="1" colspan="1">3 times/week, 50 minutes</td><td valign="top" align="left" rowspan="1" colspan="1">5 weeks</td><td valign="top" align="left" rowspan="1" colspan="1">QoL, shoulder (ROM), body image</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">2005</td><td valign="top" align="left" rowspan="1" colspan="1">46</td><td valign="top" align="left" rowspan="1" colspan="1">Sandel et al</td><td valign="top" align="left" rowspan="1" colspan="1">59.7 (9.8)/59.5 (13.3)</td><td valign="top" align="left" rowspan="1" colspan="1">Dance and movement program/a waitlist control group</td><td valign="top" align="left" rowspan="1" colspan="1">19/19</td><td valign="top" align="left" rowspan="1" colspan="1">Posttreatment</td><td valign="top" align="left" rowspan="1" colspan="1">NR</td><td valign="top" align="left" rowspan="1" colspan="1">2 times/weeks for 6 weeks, 1 time/week for 6 weeks, 50–60 minutes</td><td valign="top" align="left" rowspan="1" colspan="1">12 weeks</td><td valign="top" align="left" rowspan="1" colspan="1">QoL, fatigue, distressed mood, spiritual well-being</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">2007</td><td valign="top" align="left" rowspan="1" colspan="1">47</td><td valign="top" align="left" rowspan="1" colspan="1">Moadel et al</td><td valign="top" align="left" rowspan="1" colspan="1">55.11 (10.07)/54.23 (9.81)</td><td valign="top" align="left" rowspan="1" colspan="1">Yoga/waitlist control group</td><td valign="top" align="left" rowspan="1" colspan="1">84/44</td><td valign="top" align="left" rowspan="1" colspan="1">Posttreatment</td><td valign="top" align="left" rowspan="1" colspan="1">NR</td><td valign="top" align="left" rowspan="1" colspan="1">1.5-hour weekly classes</td><td valign="top" align="left" rowspan="1" colspan="1">12 weeks</td><td valign="top" align="left" rowspan="1" colspan="1">Fasting insulin, glucose, insulin resistance, IGFs, IGFBPs</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">2003</td><td valign="top" align="left" rowspan="1" colspan="1">48</td><td valign="top" align="left" rowspan="1" colspan="1">Fairey et al</td><td valign="top" align="left" rowspan="1" colspan="1">59 (5)/58 (6)</td><td valign="top" align="left" rowspan="1" colspan="1">Cycle ergometers/control group</td><td valign="top" align="left" rowspan="1" colspan="1">25/28</td><td valign="top" align="left" rowspan="1" colspan="1">Posttreatment</td><td valign="top" align="left" rowspan="1" colspan="1">(70%–75%) of peak oxygen consumption</td><td valign="top" align="left" rowspan="1" colspan="1">3 times/week, 15–35 minutes</td><td valign="top" align="left" rowspan="1" colspan="1">15 weeks</td><td valign="top" align="left" rowspan="1" colspan="1">Body composition, insulin, glucose, IGF axis variables</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">2005</td><td valign="top" align="left" rowspan="1" colspan="1">49</td><td valign="top" align="left" rowspan="1" colspan="1">Schmitz et al</td><td valign="top" align="left" rowspan="1" colspan="1">53.3 (8.7)/52.8 (7.6)</td><td valign="top" align="left" rowspan="1" colspan="1">Weight training: immediate/delayed group trained</td><td valign="top" align="left" rowspan="1" colspan="1">42/43</td><td valign="top" align="left" rowspan="1" colspan="1">Posttreatment</td><td valign="top" align="left" rowspan="1" colspan="1">Upper body: symptoms allowed; lower body: the most weight lift</td><td valign="top" align="left" rowspan="1" colspan="1">2 times/week, 60 minutes</td><td valign="top" align="left" rowspan="1" colspan="1">12/6 months</td><td valign="top" align="left" rowspan="1" colspan="1">Vigor, depression, sleep, stress, physical performance</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">2012</td><td valign="top" align="left" rowspan="1" colspan="1">50</td><td valign="top" align="left" rowspan="1" colspan="1">Bower et al</td><td valign="top" align="left" rowspan="1" colspan="1">54.4 (5.7)/53.3 (4.9)</td><td valign="top" align="left" rowspan="1" colspan="1">Lyengar yoga/health education</td><td valign="top" align="left" rowspan="1" colspan="1">16/15</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">2009</td><td valign="top" align="left" rowspan="1" colspan="1">51</td><td valign="top" align="left" rowspan="1" colspan="1">Cadmus et al</td><td valign="top" align="left" rowspan="1" colspan="1">54.5 (8.2)/54 (10.9)</td><td valign="top" align="left" rowspan="1" colspan="1">Home-based exercise program: phone guide/usual care</td><td valign="top" align="left" rowspan="1" colspan="1">25/25</td><td valign="top" align="left" rowspan="1" colspan="1">During treatment</td><td valign="top" align="left" rowspan="1" colspan="1">Moderate-vigorous: 60%–80% of predicted maximal HR</td><td valign="top" align="left" rowspan="1" colspan="1">5 times/week, 30 minutes</td><td valign="top" align="left" rowspan="1" colspan="1">6 months</td><td valign="top" align="left" rowspan="1" colspan="1">Happiness, depression, anxiety, stress, self-esteem, QoL</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">2009</td><td valign="top" align="left" rowspan="1" colspan="1">51</td><td valign="top" align="left" rowspan="1" colspan="1">Cadmus et al</td><td valign="top" align="left" rowspan="1" colspan="1">56.5 (9.5)/55.1 (7.7)</td><td valign="top" align="left" rowspan="1" colspan="1">Supervised exercise intervention/usual care</td><td valign="top" align="left" rowspan="1" colspan="1">37/37</td><td valign="top" align="left" rowspan="1" colspan="1">Posttreatment</td><td valign="top" align="left" rowspan="1" colspan="1">Moderate-vigorous: 60%–80% of predicted maximal HR</td><td valign="top" align="left" rowspan="1" colspan="1">5 times/week, 30 minutes</td><td valign="top" align="left" rowspan="1" colspan="1">6 months</td><td valign="top" align="left" rowspan="1" colspan="1">Happiness, depression, anxiety, stress, self-esteem, QoL</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">2009</td><td valign="top" align="left" rowspan="1" colspan="1">52</td><td valign="top" align="left" rowspan="1" colspan="1">Danhauer et al</td><td valign="top" align="left" rowspan="1" colspan="1">54.3 (9.6)/57.2 (10.2)</td><td valign="top" align="left" rowspan="1" colspan="1">Yoga class group/waitlist group</td><td valign="top" align="left" rowspan="1" colspan="1">13/14</td><td valign="top" align="left" rowspan="1" colspan="1">Posttreatment</td><td valign="top" align="left" rowspan="1" colspan="1">NR</td><td valign="top" align="left" rowspan="1" colspan="1">1 times/week, 75 minutes</td><td valign="top" align="left" rowspan="1" colspan="1">10 weeks</td><td valign="top" align="left" rowspan="1" colspan="1">Feasibility, aerobic fitness, muscle strength, body composition, QoL, fatigue, sleep</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">2012</td><td valign="top" align="left" rowspan="1" colspan="1">53</td><td valign="top" align="left" rowspan="1" colspan="1">Hayes et al</td><td valign="top" align="left" rowspan="1" colspan="1">51.2 (8.8)/52.2 (8.6)/53.9 (7.7)</td><td valign="top" align="left" rowspan="1" colspan="1">Face-to-face/telephone exercise: aerobic strength intervention/usual care</td><td valign="top" align="left" rowspan="1" colspan="1">67/67/60</td><td valign="top" align="left" rowspan="1" colspan="1">Posttreatment</td><td valign="top" align="left" rowspan="1" colspan="1">Individually tailored</td><td valign="top" align="left" rowspan="1" colspan="1">4 times/week, 45 minutes</td><td valign="top" align="left" rowspan="1" colspan="1">8 months</td><td valign="top" align="left" rowspan="1" colspan="1">QoL, body function, fatigue, lymphedema, BMI, menopausal symptoms, anxiety, depression, pain</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">2012</td><td valign="top" align="left" rowspan="1" colspan="1">54</td><td valign="top" align="left" rowspan="1" colspan="1">Littman et al</td><td valign="top" align="left" rowspan="1" colspan="1">60.6 (7.1)/58.2 (8.8)</td><td valign="top" align="left" rowspan="1" colspan="1">Facility-based and home-based Viniyoga intervention/waitlist control group</td><td valign="top" align="left" rowspan="1" colspan="1">27/27</td><td valign="top" align="left" rowspan="1" colspan="1">Posttreatment</td><td valign="top" align="left" rowspan="1" colspan="1">NR</td><td valign="top" align="left" rowspan="1" colspan="1">5 times/week, ≥75 minutes</td><td valign="top" align="left" rowspan="1" colspan="1">6 months</td><td valign="top" align="left" rowspan="1" colspan="1">QoL, fatigue, body composition</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">2004</td><td valign="top" align="left" rowspan="1" colspan="1">55</td><td valign="top" align="left" rowspan="1" colspan="1">Mustian et al</td><td valign="top" align="left" rowspan="1" colspan="1">52(9)</td><td valign="top" align="left" rowspan="1" colspan="1">Tai Chi Chuan/psychosocial support</td><td valign="top" align="left" rowspan="1" colspan="1">11/10</td><td valign="top" align="left" rowspan="1" colspan="1">Posttreatment</td><td valign="top" align="left" rowspan="1" colspan="1">Moderate</td><td valign="top" align="left" rowspan="1" colspan="1">3 times/week, 60 minutes</td><td valign="top" align="left" rowspan="1" colspan="1">12 weeks</td><td valign="top" align="left" rowspan="1" colspan="1">QoL, self-esteem</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">2006</td><td valign="top" align="left" rowspan="1" colspan="1">56</td><td valign="top" align="left" rowspan="1" colspan="1">Ohira et al</td><td valign="top" align="left" rowspan="1" colspan="1">53.3 (8.7)/52.8 (7.6)</td><td valign="top" align="left" rowspan="1" colspan="1">Weight training/control group</td><td valign="top" align="left" rowspan="1" colspan="1">43/43 (39/40)</td><td valign="top" align="left" rowspan="1" colspan="1">Posttreatment</td><td valign="top" align="left" rowspan="1" colspan="1">NR</td><td valign="top" align="left" rowspan="1" colspan="1">2 times/week</td><td valign="top" align="left" rowspan="1" colspan="1">6 months</td><td valign="top" align="left" rowspan="1" colspan="1">QoL, depression, body composition, upper and lower body strength</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">2012</td><td valign="top" align="left" rowspan="1" colspan="1">57</td><td valign="top" align="left" rowspan="1" colspan="1">Sprod et al</td><td valign="top" align="left" rowspan="1" colspan="1">54.33 (3.55)/52.7 (2.11)</td><td valign="top" align="left" rowspan="1" colspan="1">Tai Chi Chuan exercise/standard support therapy</td><td valign="top" align="left" rowspan="1" colspan="1">9/10</td><td valign="top" align="left" rowspan="1" colspan="1">Posttreatment</td><td valign="top" align="left" rowspan="1" colspan="1">NR</td><td valign="top" align="left" rowspan="1" colspan="1">3 times/week, 60 minutes</td><td valign="top" align="left" rowspan="1" colspan="1">12 weeks</td><td valign="top" align="left" rowspan="1" colspan="1">IL-6, IL-8, IGF-I, glucose, insulin, cortisol, IGFBP-1, IGFBP-3, QoL</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">2012</td><td valign="top" align="left" rowspan="1" colspan="1">58</td><td valign="top" align="left" rowspan="1" colspan="1">Saarto et al</td><td valign="top" align="left" rowspan="1" colspan="1">52.3/52.4</td><td valign="top" align="left" rowspan="1" colspan="1">Step aerobics class and circuit training class (supervised), endurance training (home)/control group</td><td valign="top" align="left" rowspan="1" colspan="1">263/237</td><td valign="top" align="left" rowspan="1" colspan="1">Posttreatment</td><td valign="top" align="left" rowspan="1" colspan="1">86%–92% of maximal HR, 76%–85% of maximal VO2</td><td valign="top" align="left" rowspan="1" colspan="1">3–4 times/week: 1 supervised +2/3 home, 60 minutes</td><td valign="top" align="left" rowspan="1" colspan="1">12 months</td><td valign="top" align="left" rowspan="1" colspan="1">QoL, fatigue, physical fitness, physical activity</td></tr></tbody></table><table-wrap-foot><fn id="tfn1-ott-9-2153"><p><bold>Abbreviations:</bold> ACSM, American college of sports medicine; AET, aerobic exercise training; BMI, body mass index; HB, hemoglobin; HCT, hematocrit; HR, heart rate; IFGBP, insulin-like growth factor binding protein; IGF, insulin-like growth factor; IL, interleukin; NR, not reported; QoL, quality of life; RBC, red blood cell; RET, resistance exercise training; VO2 peak, peak oxygen consumption; IgA, immunoglobulin A; SD, standard deviation; ROM, range of motion; RPE, rating of perceived exertion.</p></fn></table-wrap-foot></table-wrap><table-wrap id="t2-ott-9-2153" position="float"><label>Table 2</label><caption><p>Methodological quality assessment of 33 randomized controlled trials</p></caption><table frame="hsides" rules="groups"><thead><tr><th valign="top" align="left" rowspan="1" colspan="1">Study</th><th valign="top" align="left" rowspan="1" colspan="1">Randomization</th><th valign="top" align="left" rowspan="1" colspan="1">Conceal allocation</th><th valign="top" align="left" rowspan="1" colspan="1">Similarity of baseline</th><th valign="top" align="left" rowspan="1" colspan="1">Specified eligibility criteria</th><th valign="top" align="left" rowspan="1" colspan="1">Blinding of outcome assessor</th><th valign="top" align="left" rowspan="1" colspan="1">Point estimates and measures of reliability of primary outcome</th><th valign="top" align="left" rowspan="1" colspan="1">Intention-to-treat analysis</th></tr></thead><tbody><tr><td valign="top" align="left" rowspan="1" colspan="1">Basen-Engquist et al, 2006<xref rid="b26-ott-9-2153" ref-type="bibr">26</xref></td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">−</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">−</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Battaglini, 2007<xref rid="b27-ott-9-2153" ref-type="bibr">27</xref></td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">−</td><td valign="top" align="left" rowspan="1" colspan="1">−</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">−</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">−</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Bower et al, 2014<xref rid="b28-ott-9-2153" ref-type="bibr">28</xref></td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">−</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">−</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">−</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Cantarero-Villanueva et al, 2011<xref rid="b29-ott-9-2153" ref-type="bibr">29</xref></td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Courneya et al, 2007<xref rid="b30-ott-9-2153" ref-type="bibr">30</xref></td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">−</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">−</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Daley et al, 2007<xref rid="b31-ott-9-2153" ref-type="bibr">31</xref></td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">−</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Drouin et al, 2006<xref rid="b32-ott-9-2153" ref-type="bibr">32</xref></td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">−</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">−</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">−</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Irwin et al, 2009<xref rid="b33-ott-9-2153" ref-type="bibr">33</xref></td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">−</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Irwin et al, 2009<xref rid="b34-ott-9-2153" ref-type="bibr">34</xref></td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">−</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Janelsins et al, 2011<xref rid="b35-ott-9-2153" ref-type="bibr">35</xref></td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">−</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">−</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Milne et al, 2008<xref rid="b36-ott-9-2153" ref-type="bibr">36</xref></td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">−</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Mutrieet et al, 2007<xref rid="b37-ott-9-2153" ref-type="bibr">37</xref></td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">−</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Nikander et al, 2007<xref rid="b38-ott-9-2153" ref-type="bibr">38</xref></td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">−</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">−</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Rao et al, 2009<xref rid="b39-ott-9-2153" ref-type="bibr">39</xref></td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">−</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">−</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Rogers et al, 2013<xref rid="b40-ott-9-2153" ref-type="bibr">40</xref></td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">−</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">−</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Rogers et al, 2009<xref rid="b41-ott-9-2153" ref-type="bibr">41</xref></td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">−</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">−</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Vadiraja et al, 2009<xref rid="b42-ott-9-2153" ref-type="bibr">42</xref></td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Battaglini, 2008<xref rid="b43-ott-9-2153" ref-type="bibr">43</xref></td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">−</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">−</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">−</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Courneya et al, 2003<xref rid="b44-ott-9-2153" ref-type="bibr">44</xref></td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Hwang et al, 2008<xref rid="b45-ott-9-2153" ref-type="bibr">45</xref></td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">−</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">−</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">−</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Sandel et al, 2005<xref rid="b46-ott-9-2153" ref-type="bibr">46</xref></td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">−</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Moadel et al, 2007<xref rid="b47-ott-9-2153" ref-type="bibr">47</xref></td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">−</td><td valign="top" align="left" rowspan="1" colspan="1">−</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">−</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">−</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Fairey et al, 2003<xref rid="b48-ott-9-2153" ref-type="bibr">48</xref></td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Schmitz et al, 2005<xref rid="b49-ott-9-2153" ref-type="bibr">49</xref></td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">−</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Bower et al, 2012<xref rid="b50-ott-9-2153" ref-type="bibr">50</xref></td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Cadmus et al, 2009<xref rid="b51-ott-9-2153" ref-type="bibr">51</xref></td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">−</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">−</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Danhauer et al, 2009<xref rid="b52-ott-9-2153" ref-type="bibr">52</xref></td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">−</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">−</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Hayes et al, 2012<xref rid="b53-ott-9-2153" ref-type="bibr">53</xref></td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">−</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">−</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Littman et al, 2012<xref rid="b54-ott-9-2153" ref-type="bibr">54</xref></td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">−</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">−</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Mustian et al, 2004<xref rid="b55-ott-9-2153" ref-type="bibr">55</xref></td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">−</td><td valign="top" align="left" rowspan="1" colspan="1">−</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">−</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">−</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Ohira et al, 2006<xref rid="b56-ott-9-2153" ref-type="bibr">56</xref></td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">−</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">−</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Sprod et al, 2012<xref rid="b57-ott-9-2153" ref-type="bibr">57</xref></td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">−</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">−</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Saarto et al, 2012<xref rid="b58-ott-9-2153" ref-type="bibr">58</xref></td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">−</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">−</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td></tr></tbody></table></table-wrap><table-wrap id="t3-ott-9-2153" position="float"><label>Table 3</label><caption><p>Meta-analysis of the effect of exercise intervention in breast cancer survivors</p></caption><table frame="hsides" rules="groups"><thead><tr><th valign="top" align="left" rowspan="1" colspan="1">Outcomes</th><th valign="top" align="left" rowspan="1" colspan="1">Study</th><th valign="top" align="left" rowspan="1" colspan="1">Number of subjects in intervention/control groups</th><th valign="top" align="left" rowspan="1" colspan="1"><italic>I</italic><sup>2</sup> (%)</th><th valign="top" align="left" rowspan="1" colspan="1"><italic>P</italic>-value</th><th valign="top" align="left" rowspan="1" colspan="1">95% CI</th><th valign="top" align="left" rowspan="1" colspan="1">Publication bias (<italic>P</italic>-value)</th></tr></thead><tbody><tr><td valign="top" align="left" rowspan="1" colspan="1">The quality of life (SF-36)</td><td valign="top" align="left" rowspan="1" colspan="1">10</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Mental health</td><td valign="top" align="left" rowspan="1" colspan="1">4</td><td valign="top" align="left" rowspan="1" colspan="1">125/116</td><td valign="top" align="left" rowspan="1" colspan="1">18</td><td valign="top" align="left" rowspan="1" colspan="1">0.03</td><td valign="top" align="left" rowspan="1" colspan="1">1.04 (0.09, 2.00)</td><td valign="top" align="left" rowspan="1" colspan="1">0.917</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Role (physical)</td><td valign="top" align="left" rowspan="1" colspan="1">4</td><td valign="top" align="left" rowspan="1" colspan="1">125/116</td><td valign="top" align="left" rowspan="1" colspan="1">95</td><td valign="top" align="left" rowspan="1" colspan="1">0.95</td><td valign="top" align="left" rowspan="1" colspan="1">0.11 (−3.54, 3.76)</td><td valign="top" align="left" rowspan="1" colspan="1">0.829</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Social function</td><td valign="top" align="left" rowspan="1" colspan="1">3</td><td valign="top" align="left" rowspan="1" colspan="1">106/97</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0.18</td><td valign="top" align="left" rowspan="1" colspan="1">−0.36 (−0.88, 0.16)</td><td valign="top" align="left" rowspan="1" colspan="1">0.289</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Vitality</td><td valign="top" align="left" rowspan="1" colspan="1">3</td><td valign="top" align="left" rowspan="1" colspan="1">106/97</td><td valign="top" align="left" rowspan="1" colspan="1">61</td><td valign="top" align="left" rowspan="1" colspan="1">0.16</td><td valign="top" align="left" rowspan="1" colspan="1">1.35 (−0.53, 3.23)</td><td valign="top" align="left" rowspan="1" colspan="1">0.936</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Pain</td><td valign="top" align="left" rowspan="1" colspan="1">3</td><td valign="top" align="left" rowspan="1" colspan="1">106/97</td><td valign="top" align="left" rowspan="1" colspan="1">98</td><td valign="top" align="left" rowspan="1" colspan="1">0.33</td><td valign="top" align="left" rowspan="1" colspan="1">2.58 (−2.65, 7.81)</td><td valign="top" align="left" rowspan="1" colspan="1">0.418</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">General health</td><td valign="top" align="left" rowspan="1" colspan="1">3</td><td valign="top" align="left" rowspan="1" colspan="1">106/97</td><td valign="top" align="left" rowspan="1" colspan="1">95</td><td valign="top" align="left" rowspan="1" colspan="1">0.02</td><td valign="top" align="left" rowspan="1" colspan="1">4.59 (0.70, 8.48)</td><td valign="top" align="left" rowspan="1" colspan="1">0.113</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Role (emotion)</td><td valign="top" align="left" rowspan="1" colspan="1">3</td><td valign="top" align="left" rowspan="1" colspan="1">106/97</td><td valign="top" align="left" rowspan="1" colspan="1">13</td><td valign="top" align="left" rowspan="1" colspan="1">0.6</td><td valign="top" align="left" rowspan="1" colspan="1">−0.10 (−0.46, 0.26)</td><td valign="top" align="left" rowspan="1" colspan="1">0.062</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">FACT-G</td><td valign="top" align="left" rowspan="1" colspan="1">6</td><td valign="top" align="left" rowspan="1" colspan="1">237/200</td><td valign="top" align="left" rowspan="1" colspan="1">87</td><td valign="top" align="left" rowspan="1" colspan="1">0.08</td><td valign="top" align="left" rowspan="1" colspan="1">6.02 (−0.73, 12.76)</td><td valign="top" align="left" rowspan="1" colspan="1">0.482</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">TACT: TOI</td><td valign="top" align="left" rowspan="1" colspan="1">2</td><td valign="top" align="left" rowspan="1" colspan="1">54/57</td><td valign="top" align="left" rowspan="1" colspan="1">96</td><td valign="top" align="left" rowspan="1" colspan="1">0.23</td><td valign="top" align="left" rowspan="1" colspan="1">13.04 (−8.13, 34.20)</td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">FACT-G: social well-being</td><td valign="top" align="left" rowspan="1" colspan="1">8</td><td valign="top" align="left" rowspan="1" colspan="1">343/316</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0.01</td><td valign="top" align="left" rowspan="1" colspan="1">0.94 (0.19, 1.69)</td><td valign="top" align="left" rowspan="1" colspan="1">0.889</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">FACT-G: function well-being</td><td valign="top" align="left" rowspan="1" colspan="1">8</td><td valign="top" align="left" rowspan="1" colspan="1">343/316</td><td valign="top" align="left" rowspan="1" colspan="1">83</td><td valign="top" align="left" rowspan="1" colspan="1">0.07</td><td valign="top" align="left" rowspan="1" colspan="1">0.37 (−0.03, 0.77)</td><td valign="top" align="left" rowspan="1" colspan="1">0.589</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">FACT-G: emotion well-being</td><td valign="top" align="left" rowspan="1" colspan="1">8</td><td valign="top" align="left" rowspan="1" colspan="1">343/316</td><td valign="top" align="left" rowspan="1" colspan="1">2</td><td valign="top" align="left" rowspan="1" colspan="1">0.0006</td><td valign="top" align="left" rowspan="1" colspan="1">0.27 (0.12, 0.43)</td><td valign="top" align="left" rowspan="1" colspan="1">0.889</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">FACT-G: physical well-being</td><td valign="top" align="left" rowspan="1" colspan="1">8</td><td valign="top" align="left" rowspan="1" colspan="1">343/316</td><td valign="top" align="left" rowspan="1" colspan="1">88</td><td valign="top" align="left" rowspan="1" colspan="1">0.15</td><td valign="top" align="left" rowspan="1" colspan="1">1.53 (−0.57, 3.63)</td><td valign="top" align="left" rowspan="1" colspan="1">0.574</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">FACT-B subscale</td><td valign="top" align="left" rowspan="1" colspan="1">5</td><td valign="top" align="left" rowspan="1" colspan="1">225/238</td><td valign="top" align="left" rowspan="1" colspan="1">15</td><td valign="top" align="left" rowspan="1" colspan="1"><0.00001</td><td valign="top" align="left" rowspan="1" colspan="1">2.96 (1.87, 4.04)</td><td valign="top" align="left" rowspan="1" colspan="1">0.906</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">FACT-B</td><td valign="top" align="left" rowspan="1" colspan="1">6</td><td valign="top" align="left" rowspan="1" colspan="1">241/230</td><td valign="top" align="left" rowspan="1" colspan="1">85</td><td valign="top" align="left" rowspan="1" colspan="1">0.08</td><td valign="top" align="left" rowspan="1" colspan="1">0.46 (−0.05, 0.97)</td><td valign="top" align="left" rowspan="1" colspan="1">0.235</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Psychological outcomes</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> The Rosenberg Self-Esteem Scale</td><td valign="top" align="left" rowspan="1" colspan="1">3</td><td valign="top" align="left" rowspan="1" colspan="1">185/192</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0.02</td><td valign="top" align="left" rowspan="1" colspan="1">1.02 (0.18, 2.22)</td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> The 2-item Fordyce Happiness Measure</td><td valign="top" align="left" rowspan="1" colspan="1">2</td><td valign="top" align="left" rowspan="1" colspan="1">87/90</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0.66</td><td valign="top" align="left" rowspan="1" colspan="1">1.34 (−4.64, 7.32)</td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Depression</td><td valign="top" align="left" rowspan="1" colspan="1">6</td><td valign="top" align="left" rowspan="1" colspan="1">378/373</td><td valign="top" align="left" rowspan="1" colspan="1">2</td><td valign="top" align="left" rowspan="1" colspan="1">0.001</td><td valign="top" align="left" rowspan="1" colspan="1">−2.08 (−3.36, −0.80)</td><td valign="top" align="left" rowspan="1" colspan="1">0.236</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Anxiety</td><td valign="top" align="left" rowspan="1" colspan="1">5</td><td valign="top" align="left" rowspan="1" colspan="1">341/361</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1"><0.0001</td><td valign="top" align="left" rowspan="1" colspan="1">−3.17 (−4.76, −1.58)</td><td valign="top" align="left" rowspan="1" colspan="1">0.200</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Positive and negative affect scale</td><td valign="top" align="left" rowspan="1" colspan="1">3</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> PANAS negative</td><td valign="top" align="left" rowspan="1" colspan="1">3</td><td valign="top" align="left" rowspan="1" colspan="1">142/150</td><td valign="top" align="left" rowspan="1" colspan="1">76</td><td valign="top" align="left" rowspan="1" colspan="1">0.02</td><td valign="top" align="left" rowspan="1" colspan="1">−5.31 (−9.92, −0.71)</td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> PANAS positive</td><td valign="top" align="left" rowspan="1" colspan="1">3</td><td valign="top" align="left" rowspan="1" colspan="1">142/150</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1"><0.0001</td><td valign="top" align="left" rowspan="1" colspan="1">4.46 (2.48, 6.44)</td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> FACIT-Spiritual</td><td valign="top" align="left" rowspan="1" colspan="1">2</td><td valign="top" align="left" rowspan="1" colspan="1">97/58</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0.02</td><td valign="top" align="left" rowspan="1" colspan="1">4.04 (0.76, 7.13)</td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> The Perceived Stress Scale</td><td valign="top" align="left" rowspan="1" colspan="1">2</td><td valign="top" align="left" rowspan="1" colspan="1">78/77</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0.08</td><td valign="top" align="left" rowspan="1" colspan="1">−1.94 (−4.11, 0.22)</td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Sleep dysfunction</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> The Pittsburgh Sleep Quality Index</td><td valign="top" align="left" rowspan="1" colspan="1">4</td><td valign="top" align="left" rowspan="1" colspan="1">64/62</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0.58</td><td valign="top" align="left" rowspan="1" colspan="1">0.32 (−0.82, 1.46)</td><td valign="top" align="left" rowspan="1" colspan="1">0.082</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Body composition</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Body mass index</td><td valign="top" align="left" rowspan="1" colspan="1">9</td><td valign="top" align="left" rowspan="1" colspan="1">270/283</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1"><0.0001</td><td valign="top" align="left" rowspan="1" colspan="1">−0.78 (−1.09, −0.47)</td><td valign="top" align="left" rowspan="1" colspan="1">0.599</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Lean body mass/lean mass</td><td valign="top" align="left" rowspan="1" colspan="1">4</td><td valign="top" align="left" rowspan="1" colspan="1">246/252</td><td valign="top" align="left" rowspan="1" colspan="1">57</td><td valign="top" align="left" rowspan="1" colspan="1">0.04</td><td valign="top" align="left" rowspan="1" colspan="1">1.17 (0.08, 2,25)</td><td valign="top" align="left" rowspan="1" colspan="1">0.140</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Body fat %</td><td valign="top" align="left" rowspan="1" colspan="1">5</td><td valign="top" align="left" rowspan="1" colspan="1">267/272</td><td valign="top" align="left" rowspan="1" colspan="1">57</td><td valign="top" align="left" rowspan="1" colspan="1">0.02</td><td valign="top" align="left" rowspan="1" colspan="1">−1.84 (−3.33, −0.35)</td><td valign="top" align="left" rowspan="1" colspan="1">0.376</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Fat mass</td><td valign="top" align="left" rowspan="1" colspan="1">2</td><td valign="top" align="left" rowspan="1" colspan="1">169/174</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0.05</td><td valign="top" align="left" rowspan="1" colspan="1">−2.44 (−4.83, −0.04)</td><td valign="top" align="left" rowspan="1" colspan="1">0.212</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Waist-to-hip ratio</td><td valign="top" align="left" rowspan="1" colspan="1">2</td><td valign="top" align="left" rowspan="1" colspan="1">36/33</td><td valign="top" align="left" rowspan="1" colspan="1">21</td><td valign="top" align="left" rowspan="1" colspan="1">0.19</td><td valign="top" align="left" rowspan="1" colspan="1">−0.02 (−0.04, 0.01)</td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Waist circumference</td><td valign="top" align="left" rowspan="1" colspan="1">3</td><td valign="top" align="left" rowspan="1" colspan="1">103/105</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0.71</td><td valign="top" align="left" rowspan="1" colspan="1">0.17 (−0.70, 1.03)</td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Hip circumference</td><td valign="top" align="left" rowspan="1" colspan="1">2</td><td valign="top" align="left" rowspan="1" colspan="1">64/65</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0.94</td><td valign="top" align="left" rowspan="1" colspan="1">−0.16 (−4.27, 3.94)</td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Physical performance and function</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Fatigue</td><td valign="top" align="left" rowspan="1" colspan="1">10</td><td valign="top" align="left" rowspan="1" colspan="1">841/800</td><td valign="top" align="left" rowspan="1" colspan="1">83</td><td valign="top" align="left" rowspan="1" colspan="1">0.69</td><td valign="top" align="left" rowspan="1" colspan="1">0.30 (−1.16, 1.75)</td><td valign="top" align="left" rowspan="1" colspan="1">0.387</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> FACT-Fatigue subscale</td><td valign="top" align="left" rowspan="1" colspan="1">3</td><td valign="top" align="left" rowspan="1" colspan="1">120/134</td><td valign="top" align="left" rowspan="1" colspan="1">46</td><td valign="top" align="left" rowspan="1" colspan="1">0.17</td><td valign="top" align="left" rowspan="1" colspan="1">2.75 (−1.22, 6.71)</td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Fatigue Symptom Inventory</td><td valign="top" align="left" rowspan="1" colspan="1">2</td><td valign="top" align="left" rowspan="1" colspan="1">31/28</td><td valign="top" align="left" rowspan="1" colspan="1">68</td><td valign="top" align="left" rowspan="1" colspan="1">0.04</td><td valign="top" align="left" rowspan="1" colspan="1">−0.85 (−1.68, −0.02)</td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> FACIT-Fatigue</td><td valign="top" align="left" rowspan="1" colspan="1">4</td><td valign="top" align="left" rowspan="1" colspan="1">469/410</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0.96</td><td valign="top" align="left" rowspan="1" colspan="1">0.04 (−1.2, 1.27)</td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Muscle strength</td><td valign="top" align="left" rowspan="1" colspan="1">5</td><td valign="top" align="left" rowspan="1" colspan="1">235/236</td><td valign="top" align="left" rowspan="1" colspan="1">48</td><td valign="top" align="left" rowspan="1" colspan="1">0.0009</td><td valign="top" align="left" rowspan="1" colspan="1">4.27 (1.76, 6.78)</td><td valign="top" align="left" rowspan="1" colspan="1">0.272</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> VO2 peak, mL/kg/min</td><td valign="top" align="left" rowspan="1" colspan="1">2</td><td valign="top" align="left" rowspan="1" colspan="1">185/192</td><td valign="top" align="left" rowspan="1" colspan="1">52</td><td valign="top" align="left" rowspan="1" colspan="1">0.21</td><td valign="top" align="left" rowspan="1" colspan="1">0.68 (−0.38, 1.75)</td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> VO2 peak, mL/min</td><td valign="top" align="left" rowspan="1" colspan="1">2</td><td valign="top" align="left" rowspan="1" colspan="1">185/192</td><td valign="top" align="left" rowspan="1" colspan="1">46</td><td valign="top" align="left" rowspan="1" colspan="1">0.19</td><td valign="top" align="left" rowspan="1" colspan="1">0.06 (−0.03, 0.14)</td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Physiological markers</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> IL-6</td><td valign="top" align="left" rowspan="1" colspan="1">4</td><td valign="top" align="left" rowspan="1" colspan="1">46/45</td><td valign="top" align="left" rowspan="1" colspan="1">70</td><td valign="top" align="left" rowspan="1" colspan="1">0.36</td><td valign="top" align="left" rowspan="1" colspan="1">1.01 (−1.14, 3.15)</td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> IL-6 change</td><td valign="top" align="left" rowspan="1" colspan="1">4</td><td valign="top" align="left" rowspan="1" colspan="1">46/45</td><td valign="top" align="left" rowspan="1" colspan="1">69</td><td valign="top" align="left" rowspan="1" colspan="1">0.02</td><td valign="top" align="left" rowspan="1" colspan="1">1.46 (0.27, 2.65)</td><td valign="top" align="left" rowspan="1" colspan="1">0.046</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> IL-8</td><td valign="top" align="left" rowspan="1" colspan="1">2</td><td valign="top" align="left" rowspan="1" colspan="1">21/20</td><td valign="top" align="left" rowspan="1" colspan="1">76</td><td valign="top" align="left" rowspan="1" colspan="1">0.07</td><td valign="top" align="left" rowspan="1" colspan="1">1.38 (−0.09, 2.86)</td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Glucose</td><td valign="top" align="left" rowspan="1" colspan="1">3</td><td valign="top" align="left" rowspan="1" colspan="1">71/77</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0.35</td><td valign="top" align="left" rowspan="1" colspan="1">0.27 (−0.29, 0.82)</td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Glucose change</td><td valign="top" align="left" rowspan="1" colspan="1">3</td><td valign="top" align="left" rowspan="1" colspan="1">71/77</td><td valign="top" align="left" rowspan="1" colspan="1">99</td><td valign="top" align="left" rowspan="1" colspan="1"><0.00001</td><td valign="top" align="left" rowspan="1" colspan="1">1.73 (1.36, 2.11)</td><td valign="top" align="left" rowspan="1" colspan="1">0.687</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Insulin</td><td valign="top" align="left" rowspan="1" colspan="1">5</td><td valign="top" align="left" rowspan="1" colspan="1">117/126</td><td valign="top" align="left" rowspan="1" colspan="1">95</td><td valign="top" align="left" rowspan="1" colspan="1">0.05</td><td valign="top" align="left" rowspan="1" colspan="1">−6.79 (−13.64, 0.06)</td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Insulin change</td><td valign="top" align="left" rowspan="1" colspan="1">5</td><td valign="top" align="left" rowspan="1" colspan="1">117/126</td><td valign="top" align="left" rowspan="1" colspan="1">97</td><td valign="top" align="left" rowspan="1" colspan="1">0.04</td><td valign="top" align="left" rowspan="1" colspan="1">−4.98 (−9.26, −0.33)</td><td valign="top" align="left" rowspan="1" colspan="1">0.353</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> IGF-1</td><td valign="top" align="left" rowspan="1" colspan="1">5</td><td valign="top" align="left" rowspan="1" colspan="1">119/126</td><td valign="top" align="left" rowspan="1" colspan="1">99</td><td valign="top" align="left" rowspan="1" colspan="1">0.47</td><td valign="top" align="left" rowspan="1" colspan="1">7.46 (−12.94, 27.87)</td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> IGF-1 change</td><td valign="top" align="left" rowspan="1" colspan="1">5</td><td valign="top" align="left" rowspan="1" colspan="1">119/126</td><td valign="top" align="left" rowspan="1" colspan="1">99</td><td valign="top" align="left" rowspan="1" colspan="1">0.53</td><td valign="top" align="left" rowspan="1" colspan="1">6.5 (−13.88, 26.89)</td><td valign="top" align="left" rowspan="1" colspan="1">0.957</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> IGF-II</td><td valign="top" align="left" rowspan="1" colspan="1">2</td><td valign="top" align="left" rowspan="1" colspan="1">64/68</td><td valign="top" align="left" rowspan="1" colspan="1">88</td><td valign="top" align="left" rowspan="1" colspan="1">0.94</td><td valign="top" align="left" rowspan="1" colspan="1">4.36 (−110.03, 118.75)</td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> IGF-II change</td><td valign="top" align="left" rowspan="1" colspan="1">2</td><td valign="top" align="left" rowspan="1" colspan="1">64/68</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1"><0.0001</td><td valign="top" align="left" rowspan="1" colspan="1">−54.21 (−61.41, −47.00)</td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> IGFBP-1</td><td valign="top" align="left" rowspan="1" colspan="1">4</td><td valign="top" align="left" rowspan="1" colspan="1">82/88</td><td valign="top" align="left" rowspan="1" colspan="1">46</td><td valign="top" align="left" rowspan="1" colspan="1"><0.0001</td><td valign="top" align="left" rowspan="1" colspan="1">−3.16 (−4.40, −1.91)</td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> IGFBP-1 change</td><td valign="top" align="left" rowspan="1" colspan="1">4</td><td valign="top" align="left" rowspan="1" colspan="1">82/88</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1"><0.0001</td><td valign="top" align="left" rowspan="1" colspan="1">−2.93 (−3.93, −1.93)</td><td valign="top" align="left" rowspan="1" colspan="1">0.639</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> IGFBP-3</td><td valign="top" align="left" rowspan="1" colspan="1">5</td><td valign="top" align="left" rowspan="1" colspan="1">119/126</td><td valign="top" align="left" rowspan="1" colspan="1">93</td><td valign="top" align="left" rowspan="1" colspan="1">0.9</td><td valign="top" align="left" rowspan="1" colspan="1">−0.2 (−3.24, 2.48)</td><td valign="top" align="left" rowspan="1" colspan="1">0.830</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> IGFBP-3 change</td><td valign="top" align="left" rowspan="1" colspan="1">5</td><td valign="top" align="left" rowspan="1" colspan="1">119/126</td><td valign="top" align="left" rowspan="1" colspan="1">86</td><td valign="top" align="left" rowspan="1" colspan="1">0.55</td><td valign="top" align="left" rowspan="1" colspan="1">0.49 (−1.11, 2.08)</td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr></tbody></table><table-wrap-foot><fn id="tfn2-ott-9-2153"><p><bold>Abbreviations:</bold> FACT-B, Functional Assessment of Cancer Therapy–Breast Questionnaire; FACT-G, Functional Assessment of Cancer Therapy-General; FACIT–Spiritual, Functional Assessment of Chronic Illness Therapy–Spiritual well-being scale; IGF-I, insulin-like growth factor-I; IGF-II, insulin-like growth factor-II; IGFBP-1, insulin-like growth factor binding protein-1; IGFBP-3, insulin-like growth factor binding protein-3; IL, interleukin; PANAS, Positive and Negative Affect Schedule; SF-36, short form 36 questionnaire; VO2 peak, peak oxygen consumption; CI, confidence interval; TOI, Trial Outcome Index; FACIT-Fatigue, Functional Assessment of Chronic Illness Therapy–Fatigue Scale.</p></fn></table-wrap-foot></table-wrap></floats-group></pmc><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Zhu, Guoqing" sort="Zhu, Guoqing" uniqKey="Zhu G" first="Guoqing" last="Zhu">Guoqing Zhu</name></noRegion><name sortKey="Sun, Fenyong" sort="Sun, Fenyong" uniqKey="Sun F" first="Fenyong" last="Sun">Fenyong Sun</name><name sortKey="Wang, Yulan" sort="Wang, Yulan" uniqKey="Wang Y" first="Yulan" last="Wang">Yulan Wang</name><name sortKey="Xiong, Huizi" sort="Xiong, Huizi" uniqKey="Xiong H" first="Huizi" last="Xiong">Huizi Xiong</name><name sortKey="Zhang, Xiao" sort="Zhang, Xiao" uniqKey="Zhang X" first="Xiao" last="Zhang">Xiao Zhang</name><name sortKey="Zhao, Yinghui" sort="Zhao, Yinghui" uniqKey="Zhao Y" first="Yinghui" last="Zhao">Yinghui Zhao</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Pmc/Checkpoint
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