Effects of intraarticular 32P colloid in the treatment of hemophilic synovitis of the knee: A short term clinical study
Identifieur interne : 000A12 ( Pmc/Checkpoint ); précédent : 000A11; suivant : 000A13Effects of intraarticular 32P colloid in the treatment of hemophilic synovitis of the knee: A short term clinical study
Auteurs : Wen-Qiang Zhang [République populaire de Chine] ; Shao-Qin Han [République populaire de Chine] ; Zhen Yuan [République populaire de Chine] ; Ye-Teng He [République populaire de Chine] ; Hu Zhang [République populaire de Chine] ; Ming Zhang [République populaire de Chine]Source :
- Indian Journal of Orthopaedics [ 0019-5413 ] ; 2016.
Abstract
Chronic synovitis is a consequence of recurrent intraarticular hemorrhage in patients with hemophilia. Eventually, synovitis leads to degeneration of the articular cartilage, with serious consequences that impact the quality-of-life in hemophiliacs. The aim of our study was to investigate the short term clinical effects of intraarticular injection of the radionuclide preparation32P colloid (32P-labelled colloidal chromic phosphate suspension) on recurrent intraarticular hemorrhages in patients with hemophilic synovitis of the knee.
Patients who met the inclusion criteria (
In 24 knees evaluated in 22 participating patients, there was a significant reduction in the number of hemorrhages after32P colloid treatment, along with significant pain relief. However, there were no statistically significant changes in the degree of joint swelling, degree of muscle atrophy and knee ROM between the pre and post treatment evaluations.
The frequency of joint hemorrhage in patients with hemophilic knee synovitis can be significantly reduced and local symptoms can be improved in the short term by intraarticular injection of32P colloid.
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DOI: 10.4103/0019-5413.173507
PubMed: 26955177
PubMed Central: 4759875
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China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Orthopaedics, Shandong Qianfoshan Hospital, Affiliated to Shandong University, Jinan, Shandong</wicri:regionArea><wicri:noRegion>Shandong</wicri:noRegion></affiliation></author><author><name sortKey="Han, Shao Qin" sort="Han, Shao Qin" uniqKey="Han S" first="Shao-Qin" last="Han">Shao-Qin Han</name><affiliation wicri:level="1"><nlm:aff id="aff2">Blood Component Department, Blood Center of Shandong Province, Jinan, Shandong, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Blood Component Department, Blood Center of Shandong Province, Jinan, Shandong</wicri:regionArea><wicri:noRegion>Shandong</wicri:noRegion></affiliation></author><author><name sortKey="Yuan, Zhen" sort="Yuan, Zhen" uniqKey="Yuan Z" first="Zhen" last="Yuan">Zhen Yuan</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Orthopaedics, Shandong Qianfoshan Hospital, Affiliated to Shandong University, Jinan, Shandong, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Orthopaedics, Shandong Qianfoshan Hospital, Affiliated to Shandong University, Jinan, Shandong</wicri:regionArea><wicri:noRegion>Shandong</wicri:noRegion></affiliation></author><author><name sortKey="He, Ye Teng" sort="He, Ye Teng" uniqKey="He Y" first="Ye-Teng" last="He">Ye-Teng He</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Orthopaedics, Shandong Qianfoshan Hospital, Affiliated to Shandong University, Jinan, Shandong, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Orthopaedics, Shandong Qianfoshan Hospital, Affiliated to Shandong University, Jinan, Shandong</wicri:regionArea><wicri:noRegion>Shandong</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Hu" sort="Zhang, Hu" uniqKey="Zhang H" first="Hu" last="Zhang">Hu Zhang</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Orthopaedics, Shandong Qianfoshan Hospital, Affiliated to Shandong University, Jinan, Shandong, P.R. 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China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Orthopaedics, Shandong Qianfoshan Hospital, Affiliated to Shandong University, Jinan, Shandong</wicri:regionArea><wicri:noRegion>Shandong</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26955177</idno><idno type="pmc">4759875</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759875</idno><idno type="RBID">PMC:4759875</idno><idno type="doi">10.4103/0019-5413.173507</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000748</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000748</idno><idno type="wicri:Area/Pmc/Curation">000748</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000748</idno><idno type="wicri:Area/Pmc/Checkpoint">000A12</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000A12</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Effects of intraarticular <sup>32</sup>P colloid in the treatment of hemophilic synovitis of the knee: A short term clinical study</title><author><name sortKey="Zhang, Wen Qiang" sort="Zhang, Wen Qiang" uniqKey="Zhang W" first="Wen-Qiang" last="Zhang">Wen-Qiang Zhang</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Orthopaedics, Shandong Qianfoshan Hospital, Affiliated to Shandong University, Jinan, Shandong, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Orthopaedics, Shandong Qianfoshan Hospital, Affiliated to Shandong University, Jinan, Shandong</wicri:regionArea><wicri:noRegion>Shandong</wicri:noRegion></affiliation></author><author><name sortKey="Han, Shao Qin" sort="Han, Shao Qin" uniqKey="Han S" first="Shao-Qin" last="Han">Shao-Qin Han</name><affiliation wicri:level="1"><nlm:aff id="aff2">Blood Component Department, Blood Center of Shandong Province, Jinan, Shandong, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Blood Component Department, Blood Center of Shandong Province, Jinan, Shandong</wicri:regionArea><wicri:noRegion>Shandong</wicri:noRegion></affiliation></author><author><name sortKey="Yuan, Zhen" sort="Yuan, Zhen" uniqKey="Yuan Z" first="Zhen" last="Yuan">Zhen Yuan</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Orthopaedics, Shandong Qianfoshan Hospital, Affiliated to Shandong University, Jinan, Shandong, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Orthopaedics, Shandong Qianfoshan Hospital, Affiliated to Shandong University, Jinan, Shandong</wicri:regionArea><wicri:noRegion>Shandong</wicri:noRegion></affiliation></author><author><name sortKey="He, Ye Teng" sort="He, Ye Teng" uniqKey="He Y" first="Ye-Teng" last="He">Ye-Teng He</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Orthopaedics, Shandong Qianfoshan Hospital, Affiliated to Shandong University, Jinan, Shandong, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Orthopaedics, Shandong Qianfoshan Hospital, Affiliated to Shandong University, Jinan, Shandong</wicri:regionArea><wicri:noRegion>Shandong</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Hu" sort="Zhang, Hu" uniqKey="Zhang H" first="Hu" last="Zhang">Hu Zhang</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Orthopaedics, Shandong Qianfoshan Hospital, Affiliated to Shandong University, Jinan, Shandong, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Orthopaedics, Shandong Qianfoshan Hospital, Affiliated to Shandong University, Jinan, Shandong</wicri:regionArea><wicri:noRegion>Shandong</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Ming" sort="Zhang, Ming" uniqKey="Zhang M" first="Ming" last="Zhang">Ming Zhang</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Orthopaedics, Shandong Qianfoshan Hospital, Affiliated to Shandong University, Jinan, Shandong, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Orthopaedics, Shandong Qianfoshan Hospital, Affiliated to Shandong University, Jinan, Shandong</wicri:regionArea><wicri:noRegion>Shandong</wicri:noRegion></affiliation></author></analytic><series><title level="j">Indian Journal of Orthopaedics</title><idno type="ISSN">0019-5413</idno><idno type="eISSN">1998-3727</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="st1"><title>Background:</title><p>Chronic synovitis is a consequence of recurrent intraarticular hemorrhage in patients with hemophilia. Eventually, synovitis leads to degeneration of the articular cartilage, with serious consequences that impact the quality-of-life in hemophiliacs. The aim of our study was to investigate the short term clinical effects of intraarticular injection of the radionuclide preparation<sup>32</sup>P colloid (<sup>32</sup>P-labelled colloidal chromic phosphate suspension) on recurrent intraarticular hemorrhages in patients with hemophilic synovitis of the knee.</p></sec><sec id="st2"><title>Materials and Methods:</title><p>Patients who met the inclusion criteria (<italic>n</italic> = 22) were enrolled in an open-label study between October 2011 and September 2012.<sup>32</sup>P colloid was injected into the knee joint and patients were followed up over 6 months after treatment. Hemorrhage frequency, visual analog scale pain score, hospital for special surgery knee score, knee circumference, upper knee circumference, knee diameter, and knee range of motion (ROM) were compared before and after treatment with intraarticular<sup>32</sup>P colloid injection.</p></sec><sec id="st3"><title>Results:</title><p>In 24 knees evaluated in 22 participating patients, there was a significant reduction in the number of hemorrhages after<sup>32</sup>P colloid treatment, along with significant pain relief. However, there were no statistically significant changes in the degree of joint swelling, degree of muscle atrophy and knee ROM between the pre and post treatment evaluations.</p></sec><sec id="st4"><title>Conclusion:</title><p>The frequency of joint hemorrhage in patients with hemophilic knee synovitis can be significantly reduced and local symptoms can be improved in the short term by intraarticular injection of<sup>32</sup>P colloid.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Howson, Mp" uniqKey="Howson M">MP Howson</name></author><author><name sortKey="Shepard, Nl" uniqKey="Shepard N">NL Shepard</name></author><author><name sortKey="Mitchell, Ns" uniqKey="Mitchell N">NS Mitchell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rivard, Ge" uniqKey="Rivard G">GE Rivard</name></author><author><name sortKey="Girard, M" uniqKey="Girard M">M Girard</name></author><author><name sortKey="Belanger, R" uniqKey="Belanger R">R Bélanger</name></author><author><name sortKey="Jutras, M" uniqKey="Jutras M">M Jutras</name></author><author><name sortKey="Guay, Jp" uniqKey="Guay J">JP Guay</name></author><author><name sortKey="Marton, D" uniqKey="Marton D">D Marton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mortazavi, Sm" uniqKey="Mortazavi S">SM Mortazavi</name></author><author><name sortKey="Asadollahi, S" uniqKey="Asadollahi S">S Asadollahi</name></author><author><name sortKey="Farzan, M" uniqKey="Farzan M">M Farzan</name></author><author><name sortKey="Shahriaran, S" uniqKey="Shahriaran S">S Shahriaran</name></author><author><name sortKey="Aghili, M" uniqKey="Aghili M">M Aghili</name></author><author><name sortKey="Izadyar, S" uniqKey="Izadyar S">S Izadyar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Harold, R" uniqKey="Harold R">R Harold</name></author><author><name sortKey="Robe, S" uniqKey="Robe S">S Robe</name></author><author><name sortKey="Hoffman, M" uniqKey="Hoffman M">M Hoffman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mauser Bunschoten, Ep" uniqKey="Mauser Bunschoten E">EP Mauser-Bunschoten</name></author><author><name sortKey="Zijl, Ja" uniqKey="Zijl J">JA Zijl</name></author><author><name sortKey="Mali, W" uniqKey="Mali W">W Mali</name></author><author><name sortKey="Van Rinsum, Ac" uniqKey="Van Rinsum A">AC van Rinsum</name></author><author><name sortKey="Van Den Berg, Hm" uniqKey="Van Den Berg H">HM van den Berg</name></author><author><name sortKey="Roosendaal, G" uniqKey="Roosendaal G">G Roosendaal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ohdera, T" uniqKey="Ohdera T">T Ohdera</name></author><author><name sortKey="Tokunaga, M" uniqKey="Tokunaga M">M Tokunaga</name></author><author><name sortKey="Hiroshima, S" uniqKey="Hiroshima S">S Hiroshima</name></author><author><name sortKey="Yoshimoto, E" uniqKey="Yoshimoto E">E Yoshimoto</name></author><author><name sortKey="Matsuda, S" uniqKey="Matsuda S">S Matsuda</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ahlberg, A" uniqKey="Ahlberg A">A Ahlberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Silva, M" uniqKey="Silva M">M Silva</name></author><author><name sortKey="Luck, Jv" uniqKey="Luck J">JV Luck</name></author><author><name sortKey="Siegel, Me" uniqKey="Siegel M">ME Siegel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fernandez Palazzi, F" uniqKey="Fernandez Palazzi F">F Fernandez-Palazzi</name></author><author><name sortKey="Rivas, S" uniqKey="Rivas S">S Rivas</name></author><author><name sortKey="Cibeira, Jl" uniqKey="Cibeira J">JL Cibeira</name></author><author><name sortKey="Dib, O" uniqKey="Dib O">O Dib</name></author><author><name sortKey="Viso, R" uniqKey="Viso R">R Viso</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rodriguez Merchan, Ec" uniqKey="Rodriguez Merchan E">EC Rodriguez-Merchan</name></author><author><name sortKey="Wiedel, Jd" uniqKey="Wiedel J">JD Wiedel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Turkmen, C" uniqKey="Turkmen C">C Turkmen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Savaser, An" uniqKey="Savaser A">AN Savaser</name></author><author><name sortKey="Hoffmann, Kt" uniqKey="Hoffmann K">KT Hoffmann</name></author><author><name sortKey="Sorensen, H" uniqKey="Sorensen H">H Sörensen</name></author><author><name sortKey="Banzer, Dh" uniqKey="Banzer D">DH Banzer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peters, W" uniqKey="Peters W">W Peters</name></author><author><name sortKey="Lee, P" uniqKey="Lee P">P 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sortKey="Reiners, C" uniqKey="Reiners C">C Reiners</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Indian J Orthop</journal-id><journal-id journal-id-type="iso-abbrev">Indian J Orthop</journal-id><journal-id journal-id-type="publisher-id">IJOrtho</journal-id><journal-title-group><journal-title>Indian Journal of Orthopaedics</journal-title></journal-title-group><issn pub-type="ppub">0019-5413</issn><issn pub-type="epub">1998-3727</issn><publisher><publisher-name>Medknow Publications & Media Pvt Ltd</publisher-name><publisher-loc>India</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26955177</article-id><article-id pub-id-type="pmc">4759875</article-id><article-id pub-id-type="publisher-id">IJOrtho-50-55</article-id><article-id pub-id-type="doi">10.4103/0019-5413.173507</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject></subj-group></article-categories><title-group><article-title>Effects of intraarticular <sup>32</sup>P colloid in the treatment of hemophilic synovitis of the knee: A short term clinical study</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Zhang</surname><given-names>Wen-Qiang</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Han</surname><given-names>Shao-Qin</given-names></name><xref ref-type="aff" rid="aff2">1</xref></contrib><contrib contrib-type="author"><name><surname>Yuan</surname><given-names>Zhen</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>He</surname><given-names>Ye-Teng</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Zhang</surname><given-names>Hu</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Zhang</surname><given-names>Ming</given-names></name><xref ref-type="aff" rid="aff1"></xref><xref ref-type="corresp" rid="cor1"></xref></contrib></contrib-group><aff id="aff1">Department of Orthopaedics, Shandong Qianfoshan Hospital, Affiliated to Shandong University, Jinan, Shandong, P.R. China</aff><aff id="aff2"><label>1</label>Blood Component Department, Blood Center of Shandong Province, Jinan, Shandong, P.R. China</aff><author-notes><corresp id="cor1"><bold>Address for correspondence:</bold> Dr. Ming Zhang, Department of Orthopaedics, Shandong Qianfoshan Hospital, Affiliated to Shandong University, No. 16766, Jingshi Road, Jinan 250014, Shandong, P.R. China. E-mail: <email xlink:href="mingzhangcn2014@126.com">mingzhangcn2014@126.com</email></corresp></author-notes><pub-date pub-type="ppub"><season>Jan-Feb</season><year>2016</year></pub-date><volume>50</volume><issue>1</issue><fpage>55</fpage><lpage>58</lpage><permissions><copyright-statement>Copyright: © Indian Journal of Orthopaedics</copyright-statement><copyright-year>2016</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc-sa/3.0"><license-p>This is an open access article distributed under the terms of the Creative Commons Attribution NonCommercial ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non commercially, as long as the author is credited and the new creations are licensed under the identical terms.</license-p></license></permissions><abstract><sec id="st1"><title>Background:</title><p>Chronic synovitis is a consequence of recurrent intraarticular hemorrhage in patients with hemophilia. Eventually, synovitis leads to degeneration of the articular cartilage, with serious consequences that impact the quality-of-life in hemophiliacs. The aim of our study was to investigate the short term clinical effects of intraarticular injection of the radionuclide preparation<sup>32</sup>P colloid (<sup>32</sup>P-labelled colloidal chromic phosphate suspension) on recurrent intraarticular hemorrhages in patients with hemophilic synovitis of the knee.</p></sec><sec id="st2"><title>Materials and Methods:</title><p>Patients who met the inclusion criteria (<italic>n</italic> = 22) were enrolled in an open-label study between October 2011 and September 2012.<sup>32</sup>P colloid was injected into the knee joint and patients were followed up over 6 months after treatment. Hemorrhage frequency, visual analog scale pain score, hospital for special surgery knee score, knee circumference, upper knee circumference, knee diameter, and knee range of motion (ROM) were compared before and after treatment with intraarticular<sup>32</sup>P colloid injection.</p></sec><sec id="st3"><title>Results:</title><p>In 24 knees evaluated in 22 participating patients, there was a significant reduction in the number of hemorrhages after<sup>32</sup>P colloid treatment, along with significant pain relief. However, there were no statistically significant changes in the degree of joint swelling, degree of muscle atrophy and knee ROM between the pre and post treatment evaluations.</p></sec><sec id="st4"><title>Conclusion:</title><p>The frequency of joint hemorrhage in patients with hemophilic knee synovitis can be significantly reduced and local symptoms can be improved in the short term by intraarticular injection of<sup>32</sup>P colloid.</p></sec></abstract><kwd-group><kwd><sup>32</sup>P colloid</kwd><kwd>hemophilia</kwd><kwd>intraarticular injection</kwd><kwd>radiosynovectomy</kwd><kwd>synovitis</kwd></kwd-group><kwd-group kwd-group-type="MESH"><title>MeSh terms:</title><kwd>Knee joint</kwd><kwd>hemophilia</kwd><kwd>synovia</kwd><kwd>synovitis</kwd><kwd>radionuclides</kwd></kwd-group></article-meta></front></pmc><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Zhang, Wen Qiang" sort="Zhang, Wen Qiang" uniqKey="Zhang W" first="Wen-Qiang" last="Zhang">Wen-Qiang Zhang</name></noRegion><name sortKey="Han, Shao Qin" sort="Han, Shao Qin" uniqKey="Han S" first="Shao-Qin" last="Han">Shao-Qin Han</name><name sortKey="He, Ye Teng" sort="He, Ye Teng" uniqKey="He Y" first="Ye-Teng" last="He">Ye-Teng He</name><name sortKey="Yuan, Zhen" sort="Yuan, Zhen" uniqKey="Yuan Z" first="Zhen" last="Yuan">Zhen Yuan</name><name sortKey="Zhang, Hu" sort="Zhang, Hu" uniqKey="Zhang H" first="Hu" last="Zhang">Hu Zhang</name><name sortKey="Zhang, Ming" sort="Zhang, Ming" uniqKey="Zhang M" first="Ming" last="Zhang">Ming Zhang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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