The Noninvasive Treatment for Sentinel Lymph Node Metastasis by Photodynamic Therapy Using Phospholipid Polymer as a Nanotransporter of Verteporfin
Identifieur interne : 000046 ( Pmc/Checkpoint ); précédent : 000045; suivant : 000047The Noninvasive Treatment for Sentinel Lymph Node Metastasis by Photodynamic Therapy Using Phospholipid Polymer as a Nanotransporter of Verteporfin
Auteurs : Kyosuke Shimada [Japon] ; Sachiko Matsuda [Japon] ; Hiromitsu Jinno [Japon] ; Noriaki Kameyama [Japon] ; Tomohiro Konno [Japon] ; Tsunenori Arai [Japon] ; Kazuhiko Ishihara [Japon] ; Yuko Kitagawa [Japon]Source :
- BioMed Research International [ 2314-6133 ] ; 2017.
Abstract
Url:
DOI: 10.1155/2017/7412865
PubMed: 28473989
PubMed Central: 5394349
Affiliations:
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PMC:5394349Le document en format XML
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<author><name sortKey="Ishihara, Kazuhiko" sort="Ishihara, Kazuhiko" uniqKey="Ishihara K" first="Kazuhiko" last="Ishihara">Kazuhiko Ishihara</name>
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<author><name sortKey="Kitagawa, Yuko" sort="Kitagawa, Yuko" uniqKey="Kitagawa Y" first="Yuko" last="Kitagawa">Yuko Kitagawa</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The Noninvasive Treatment for Sentinel Lymph Node Metastasis by Photodynamic Therapy Using Phospholipid Polymer as a Nanotransporter of Verteporfin</title>
<author><name sortKey="Shimada, Kyosuke" sort="Shimada, Kyosuke" uniqKey="Shimada K" first="Kyosuke" last="Shimada">Kyosuke Shimada</name>
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<author><name sortKey="Matsuda, Sachiko" sort="Matsuda, Sachiko" uniqKey="Matsuda S" first="Sachiko" last="Matsuda">Sachiko Matsuda</name>
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<author><name sortKey="Kameyama, Noriaki" sort="Kameyama, Noriaki" uniqKey="Kameyama N" first="Noriaki" last="Kameyama">Noriaki Kameyama</name>
<affiliation wicri:level="1"><nlm:aff id="I5">Department of Surgery, Tachikawa Hospital, 4-2-22, Niishikicho, Tachikawa, Tokyo 190-8531, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Surgery, Tachikawa Hospital, 4-2-22, Niishikicho, Tachikawa, Tokyo 190-8531</wicri:regionArea>
<placeName><settlement type="city">Tokyo</settlement>
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<author><name sortKey="Konno, Tomohiro" sort="Konno, Tomohiro" uniqKey="Konno T" first="Tomohiro" last="Konno">Tomohiro Konno</name>
<affiliation wicri:level="4"><nlm:aff id="I6">Department of Bioengineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8656, Japan</nlm:aff>
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<wicri:regionArea>Department of Bioengineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8656</wicri:regionArea>
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<settlement type="city">Tokyo</settlement>
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<author><name sortKey="Arai, Tsunenori" sort="Arai, Tsunenori" uniqKey="Arai T" first="Tsunenori" last="Arai">Tsunenori Arai</name>
<affiliation wicri:level="1"><nlm:aff id="I7">Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku, Yokohama, Kanagawa 223-8522, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku, Yokohama, Kanagawa 223-8522</wicri:regionArea>
<wicri:noRegion>Kanagawa 223-8522</wicri:noRegion>
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<author><name sortKey="Ishihara, Kazuhiko" sort="Ishihara, Kazuhiko" uniqKey="Ishihara K" first="Kazuhiko" last="Ishihara">Kazuhiko Ishihara</name>
<affiliation wicri:level="4"><nlm:aff id="I6">Department of Bioengineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8656, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Bioengineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8656</wicri:regionArea>
<placeName><settlement type="city">Tokyo</settlement>
<region type="région">Région de Kantō</region>
<settlement type="city">Tokyo</settlement>
</placeName>
<orgName type="university">Université de Tokyo</orgName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="I8">Department of Materials Engineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8656, Japan</nlm:aff>
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<wicri:regionArea>Department of Materials Engineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8656</wicri:regionArea>
<placeName><settlement type="city">Tokyo</settlement>
<region type="région">Région de Kantō</region>
<settlement type="city">Tokyo</settlement>
</placeName>
<orgName type="university">Université de Tokyo</orgName>
</affiliation>
</author>
<author><name sortKey="Kitagawa, Yuko" sort="Kitagawa, Yuko" uniqKey="Kitagawa Y" first="Yuko" last="Kitagawa">Yuko Kitagawa</name>
<affiliation wicri:level="1"><nlm:aff id="I2">Department of Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo 160-8582, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo 160-8582</wicri:regionArea>
<placeName><settlement type="city">Tokyo</settlement>
<region type="région">Région de Kantō</region>
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<series><title level="j">BioMed Research International</title>
<idno type="ISSN">2314-6133</idno>
<idno type="eISSN">2314-6141</idno>
<imprint><date when="2017">2017</date>
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<front><div type="abstract" xml:lang="en"><p><italic>Aim</italic>
. The usefulness of photodynamic therapy (PDT) for treating sentinel lymph node (SLN) metastasis was evaluated.<italic> Materials and Methods</italic>
. Verteporfin, a hydrophobic photosensitizer, forms a soluble aggregate with poly(2-methacryloyloxyethyl phosphorylcholine-<italic>co</italic>
-<italic>n</italic>
-butyl methacrylate) (PMB). The concentrations of verteporfin were determined by measuring the fluorescence emitted at 700 nm. Seven days after the inoculation of A431 cells at the forearm of BALB/c nude mice, PMB-verteporfin was injected at dorsum manus and 75 J of light energy was delivered for 1 minute. Fifty-three mice were randomly assigned to the combination of PMB-verteporfin injection and light exposure, light exposure alone, PMB-verteporfin injection alone, and no treatment groups. Ten days after PDT, brachial lymph nodes, which were considered as SLNs, were harvested and evaluated.<italic> Results</italic>
. The concentration of verteporfin in SLN was significantly higher than other organs. The combination of PMB-verteporfin injection and light exposure group significantly reduced the SLN metastasis (13%) comparing with no treatment group (52%), light exposure alone group (57%), and PMB-verteporfin injection alone group (46%).<italic> Conclusions</italic>
. These data suggested that PDT using PMB as a nanotransporter of verteporfin could be a minimally invasive treatment of SLN metastasis in breast cancer and represent a potential alternative procedure to SLNB.</p>
</div>
</front>
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<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Biomed Res Int</journal-id>
<journal-id journal-id-type="iso-abbrev">Biomed Res Int</journal-id>
<journal-id journal-id-type="publisher-id">BMRI</journal-id>
<journal-title-group><journal-title>BioMed Research International</journal-title>
</journal-title-group>
<issn pub-type="ppub">2314-6133</issn>
<issn pub-type="epub">2314-6141</issn>
<publisher><publisher-name>Hindawi</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">28473989</article-id>
<article-id pub-id-type="pmc">5394349</article-id>
<article-id pub-id-type="doi">10.1155/2017/7412865</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>The Noninvasive Treatment for Sentinel Lymph Node Metastasis by Photodynamic Therapy Using Phospholipid Polymer as a Nanotransporter of Verteporfin</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Shimada</surname>
<given-names>Kyosuke</given-names>
</name>
<xref ref-type="aff" rid="I1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Matsuda</surname>
<given-names>Sachiko</given-names>
</name>
<xref ref-type="aff" rid="I2"><sup>2</sup>
</xref>
<xref ref-type="aff" rid="I3"><sup>3</sup>
</xref>
</contrib>
<contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="false">http://orcid.org/0000-0002-1331-7053</contrib-id>
<name><surname>Jinno</surname>
<given-names>Hiromitsu</given-names>
</name>
<xref ref-type="aff" rid="I4"><sup>4</sup>
</xref>
<xref ref-type="corresp" rid="cor1"><sup>*</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kameyama</surname>
<given-names>Noriaki</given-names>
</name>
<xref ref-type="aff" rid="I5"><sup>5</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Konno</surname>
<given-names>Tomohiro</given-names>
</name>
<xref ref-type="aff" rid="I6"><sup>6</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Arai</surname>
<given-names>Tsunenori</given-names>
</name>
<xref ref-type="aff" rid="I7"><sup>7</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ishihara</surname>
<given-names>Kazuhiko</given-names>
</name>
<xref ref-type="aff" rid="I6"><sup>6</sup>
</xref>
<xref ref-type="aff" rid="I8"><sup>8</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kitagawa</surname>
<given-names>Yuko</given-names>
</name>
<xref ref-type="aff" rid="I2"><sup>2</sup>
</xref>
</contrib>
</contrib-group>
<aff id="I1"><sup>1</sup>
Department of Breast Surgery, Kawasaki Municipal Ida Hospital, 2-27-1 Ida, Nakahara, Kawasaki, Kanagawa 211-0035, Japan</aff>
<aff id="I2"><sup>2</sup>
Department of Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo 160-8582, Japan</aff>
<aff id="I3"><sup>3</sup>
Endowed Chair in Cancer Research, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo 160-8582, Japan</aff>
<aff id="I4"><sup>4</sup>
Department of Surgery, Teikyo University School of Medicine, 2-11-1, Kaga, Itabashi, Tokyo 173-8606, Japan</aff>
<aff id="I5"><sup>5</sup>
Department of Surgery, Tachikawa Hospital, 4-2-22, Niishikicho, Tachikawa, Tokyo 190-8531, Japan</aff>
<aff id="I6"><sup>6</sup>
Department of Bioengineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8656, Japan</aff>
<aff id="I7"><sup>7</sup>
Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku, Yokohama, Kanagawa 223-8522, Japan</aff>
<aff id="I8"><sup>8</sup>
Department of Materials Engineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8656, Japan</aff>
<author-notes><corresp id="cor1">*Hiromitsu Jinno: <email>jinnoh@dd.iij4u.or.jp</email>
</corresp>
<fn fn-type="other"><p>Academic Editor: Maurizio Battaglia Parodi</p>
</fn>
</author-notes>
<pub-date pub-type="ppub"><year>2017</year>
</pub-date>
<pub-date pub-type="epub"><day>3</day>
<month>4</month>
<year>2017</year>
</pub-date>
<volume>2017</volume>
<elocation-id>7412865</elocation-id>
<history><date date-type="received"><day>22</day>
<month>11</month>
<year>2016</year>
</date>
<date date-type="rev-recd"><day>10</day>
<month>2</month>
<year>2017</year>
</date>
<date date-type="accepted"><day>1</day>
<month>3</month>
<year>2017</year>
</date>
</history>
<permissions><copyright-statement>Copyright © 2017 Kyosuke Shimada et al.</copyright-statement>
<copyright-year>2017</copyright-year>
<license xlink:href="https://creativecommons.org/licenses/by/4.0/"><license-p>This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
</license>
</permissions>
<abstract><p><italic>Aim</italic>
. The usefulness of photodynamic therapy (PDT) for treating sentinel lymph node (SLN) metastasis was evaluated.<italic> Materials and Methods</italic>
. Verteporfin, a hydrophobic photosensitizer, forms a soluble aggregate with poly(2-methacryloyloxyethyl phosphorylcholine-<italic>co</italic>
-<italic>n</italic>
-butyl methacrylate) (PMB). The concentrations of verteporfin were determined by measuring the fluorescence emitted at 700 nm. Seven days after the inoculation of A431 cells at the forearm of BALB/c nude mice, PMB-verteporfin was injected at dorsum manus and 75 J of light energy was delivered for 1 minute. Fifty-three mice were randomly assigned to the combination of PMB-verteporfin injection and light exposure, light exposure alone, PMB-verteporfin injection alone, and no treatment groups. Ten days after PDT, brachial lymph nodes, which were considered as SLNs, were harvested and evaluated.<italic> Results</italic>
. The concentration of verteporfin in SLN was significantly higher than other organs. The combination of PMB-verteporfin injection and light exposure group significantly reduced the SLN metastasis (13%) comparing with no treatment group (52%), light exposure alone group (57%), and PMB-verteporfin injection alone group (46%).<italic> Conclusions</italic>
. These data suggested that PDT using PMB as a nanotransporter of verteporfin could be a minimally invasive treatment of SLN metastasis in breast cancer and represent a potential alternative procedure to SLNB.</p>
</abstract>
<funding-group><award-group><funding-source xlink:href="http://dx.doi.org/10.13039/501100001700">Ministry of Education, Culture, Sports, Science and Technology</funding-source>
<award-id>2306</award-id>
</award-group>
</funding-group>
</article-meta>
</front>
<floats-group><fig id="fig1" orientation="portrait" position="float"><label>Figure 1</label>
<graphic xlink:href="BMRI2017-7412865.001"></graphic>
</fig>
<fig id="fig2" orientation="portrait" position="float"><label>Figure 2</label>
<caption><p>Stereoscopic fluorescence microscope images of metastatic sentinel lymph nodes.</p>
</caption>
<graphic xlink:href="BMRI2017-7412865.002"></graphic>
</fig>
<fig id="fig3" orientation="portrait" position="float"><label>Figure 3</label>
<caption><p>Nuclear disruption in SLN after PDT.</p>
</caption>
<graphic xlink:href="BMRI2017-7412865.003"></graphic>
</fig>
<fig id="fig4" orientation="portrait" position="float"><label>Figure 4</label>
<caption><p>Amount of verteporfin distributed in various tissues.</p>
</caption>
<graphic xlink:href="BMRI2017-7412865.004"></graphic>
</fig>
<fig id="fig5" orientation="portrait" position="float"><label>Figure 5</label>
<caption><p>Effect of PDT on SLN metastasis.</p>
</caption>
<graphic xlink:href="BMRI2017-7412865.005"></graphic>
</fig>
</floats-group>
</pmc>
<affiliations><list><country><li>Japon</li>
</country>
<region><li>Région de Kantō</li>
</region>
<settlement><li>Tokyo</li>
</settlement>
<orgName><li>Université de Tokyo</li>
</orgName>
</list>
<tree><country name="Japon"><noRegion><name sortKey="Shimada, Kyosuke" sort="Shimada, Kyosuke" uniqKey="Shimada K" first="Kyosuke" last="Shimada">Kyosuke Shimada</name>
</noRegion>
<name sortKey="Arai, Tsunenori" sort="Arai, Tsunenori" uniqKey="Arai T" first="Tsunenori" last="Arai">Tsunenori Arai</name>
<name sortKey="Ishihara, Kazuhiko" sort="Ishihara, Kazuhiko" uniqKey="Ishihara K" first="Kazuhiko" last="Ishihara">Kazuhiko Ishihara</name>
<name sortKey="Ishihara, Kazuhiko" sort="Ishihara, Kazuhiko" uniqKey="Ishihara K" first="Kazuhiko" last="Ishihara">Kazuhiko Ishihara</name>
<name sortKey="Jinno, Hiromitsu" sort="Jinno, Hiromitsu" uniqKey="Jinno H" first="Hiromitsu" last="Jinno">Hiromitsu Jinno</name>
<name sortKey="Kameyama, Noriaki" sort="Kameyama, Noriaki" uniqKey="Kameyama N" first="Noriaki" last="Kameyama">Noriaki Kameyama</name>
<name sortKey="Kitagawa, Yuko" sort="Kitagawa, Yuko" uniqKey="Kitagawa Y" first="Yuko" last="Kitagawa">Yuko Kitagawa</name>
<name sortKey="Konno, Tomohiro" sort="Konno, Tomohiro" uniqKey="Konno T" first="Tomohiro" last="Konno">Tomohiro Konno</name>
<name sortKey="Matsuda, Sachiko" sort="Matsuda, Sachiko" uniqKey="Matsuda S" first="Sachiko" last="Matsuda">Sachiko Matsuda</name>
<name sortKey="Matsuda, Sachiko" sort="Matsuda, Sachiko" uniqKey="Matsuda S" first="Sachiko" last="Matsuda">Sachiko Matsuda</name>
</country>
</tree>
</affiliations>
</record>
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