The Noninvasive Treatment for Sentinel Lymph Node Metastasis by Photodynamic Therapy Using Phospholipid Polymer as a Nanotransporter of Verteporfin
Identifieur interne : 003C30 ( Pmc/Curation ); précédent : 003C29; suivant : 003C31The Noninvasive Treatment for Sentinel Lymph Node Metastasis by Photodynamic Therapy Using Phospholipid Polymer as a Nanotransporter of Verteporfin
Auteurs : Kyosuke Shimada [Japon] ; Sachiko Matsuda [Japon] ; Hiromitsu Jinno [Japon] ; Noriaki Kameyama [Japon] ; Tomohiro Konno [Japon] ; Tsunenori Arai [Japon] ; Kazuhiko Ishihara [Japon] ; Yuko Kitagawa [Japon]Source :
- BioMed Research International [ 2314-6133 ] ; 2017.
Abstract
Url:
DOI: 10.1155/2017/7412865
PubMed: 28473989
PubMed Central: 5394349
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The Noninvasive Treatment for Sentinel Lymph Node Metastasis by Photodynamic Therapy Using Phospholipid Polymer as a Nanotransporter of Verteporfin</title><author><name sortKey="Shimada, Kyosuke" sort="Shimada, Kyosuke" uniqKey="Shimada K" first="Kyosuke" last="Shimada">Kyosuke Shimada</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Breast Surgery, Kawasaki Municipal Ida Hospital, 2-27-1 Ida, Nakahara, Kawasaki, Kanagawa 211-0035, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Breast Surgery, Kawasaki Municipal Ida Hospital, 2-27-1 Ida, Nakahara, Kawasaki, Kanagawa 211-0035</wicri:regionArea></affiliation></author><author><name sortKey="Matsuda, Sachiko" sort="Matsuda, Sachiko" uniqKey="Matsuda S" first="Sachiko" last="Matsuda">Sachiko Matsuda</name><affiliation wicri:level="1"><nlm:aff id="I2">Department of Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo 160-8582, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo 160-8582</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="I3">Endowed Chair in Cancer Research, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo 160-8582, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Endowed Chair in Cancer Research, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo 160-8582</wicri:regionArea></affiliation></author><author><name sortKey="Jinno, Hiromitsu" sort="Jinno, Hiromitsu" uniqKey="Jinno H" first="Hiromitsu" last="Jinno">Hiromitsu Jinno</name><affiliation wicri:level="1"><nlm:aff id="I4">Department of Surgery, Teikyo University School of Medicine, 2-11-1, Kaga, Itabashi, Tokyo 173-8606, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Surgery, Teikyo University School of Medicine, 2-11-1, Kaga, Itabashi, Tokyo 173-8606</wicri:regionArea></affiliation></author><author><name sortKey="Kameyama, Noriaki" sort="Kameyama, Noriaki" uniqKey="Kameyama N" first="Noriaki" last="Kameyama">Noriaki Kameyama</name><affiliation wicri:level="1"><nlm:aff id="I5">Department of Surgery, Tachikawa Hospital, 4-2-22, Niishikicho, Tachikawa, Tokyo 190-8531, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Surgery, Tachikawa Hospital, 4-2-22, Niishikicho, Tachikawa, Tokyo 190-8531</wicri:regionArea></affiliation></author><author><name sortKey="Konno, Tomohiro" sort="Konno, Tomohiro" uniqKey="Konno T" first="Tomohiro" last="Konno">Tomohiro Konno</name><affiliation wicri:level="1"><nlm:aff id="I6">Department of Bioengineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8656, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Bioengineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8656</wicri:regionArea></affiliation></author><author><name sortKey="Arai, Tsunenori" sort="Arai, Tsunenori" uniqKey="Arai T" first="Tsunenori" last="Arai">Tsunenori Arai</name><affiliation wicri:level="1"><nlm:aff id="I7">Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku, Yokohama, Kanagawa 223-8522, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku, Yokohama, Kanagawa 223-8522</wicri:regionArea></affiliation></author><author><name sortKey="Ishihara, Kazuhiko" sort="Ishihara, Kazuhiko" uniqKey="Ishihara K" first="Kazuhiko" last="Ishihara">Kazuhiko Ishihara</name><affiliation wicri:level="1"><nlm:aff id="I6">Department of Bioengineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8656, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Bioengineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8656</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="I8">Department of Materials Engineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8656, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Materials Engineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8656</wicri:regionArea></affiliation></author><author><name sortKey="Kitagawa, Yuko" sort="Kitagawa, Yuko" uniqKey="Kitagawa Y" first="Yuko" last="Kitagawa">Yuko Kitagawa</name><affiliation wicri:level="1"><nlm:aff id="I2">Department of Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo 160-8582, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo 160-8582</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">28473989</idno><idno type="pmc">5394349</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5394349</idno><idno type="RBID">PMC:5394349</idno><idno type="doi">10.1155/2017/7412865</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">003C31</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">003C31</idno><idno type="wicri:Area/Pmc/Curation">003C30</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">003C30</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The Noninvasive Treatment for Sentinel Lymph Node Metastasis by Photodynamic Therapy Using Phospholipid Polymer as a Nanotransporter of Verteporfin</title><author><name sortKey="Shimada, Kyosuke" sort="Shimada, Kyosuke" uniqKey="Shimada K" first="Kyosuke" last="Shimada">Kyosuke Shimada</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Breast Surgery, Kawasaki Municipal Ida Hospital, 2-27-1 Ida, Nakahara, Kawasaki, Kanagawa 211-0035, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Breast Surgery, Kawasaki Municipal Ida Hospital, 2-27-1 Ida, Nakahara, Kawasaki, Kanagawa 211-0035</wicri:regionArea></affiliation></author><author><name sortKey="Matsuda, Sachiko" sort="Matsuda, Sachiko" uniqKey="Matsuda S" first="Sachiko" last="Matsuda">Sachiko Matsuda</name><affiliation wicri:level="1"><nlm:aff id="I2">Department of Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo 160-8582, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo 160-8582</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="I3">Endowed Chair in Cancer Research, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo 160-8582, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Endowed Chair in Cancer Research, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo 160-8582</wicri:regionArea></affiliation></author><author><name sortKey="Jinno, Hiromitsu" sort="Jinno, Hiromitsu" uniqKey="Jinno H" first="Hiromitsu" last="Jinno">Hiromitsu Jinno</name><affiliation wicri:level="1"><nlm:aff id="I4">Department of Surgery, Teikyo University School of Medicine, 2-11-1, Kaga, Itabashi, Tokyo 173-8606, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Surgery, Teikyo University School of Medicine, 2-11-1, Kaga, Itabashi, Tokyo 173-8606</wicri:regionArea></affiliation></author><author><name sortKey="Kameyama, Noriaki" sort="Kameyama, Noriaki" uniqKey="Kameyama N" first="Noriaki" last="Kameyama">Noriaki Kameyama</name><affiliation wicri:level="1"><nlm:aff id="I5">Department of Surgery, Tachikawa Hospital, 4-2-22, Niishikicho, Tachikawa, Tokyo 190-8531, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Surgery, Tachikawa Hospital, 4-2-22, Niishikicho, Tachikawa, Tokyo 190-8531</wicri:regionArea></affiliation></author><author><name sortKey="Konno, Tomohiro" sort="Konno, Tomohiro" uniqKey="Konno T" first="Tomohiro" last="Konno">Tomohiro Konno</name><affiliation wicri:level="1"><nlm:aff id="I6">Department of Bioengineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8656, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Bioengineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8656</wicri:regionArea></affiliation></author><author><name sortKey="Arai, Tsunenori" sort="Arai, Tsunenori" uniqKey="Arai T" first="Tsunenori" last="Arai">Tsunenori Arai</name><affiliation wicri:level="1"><nlm:aff id="I7">Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku, Yokohama, Kanagawa 223-8522, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku, Yokohama, Kanagawa 223-8522</wicri:regionArea></affiliation></author><author><name sortKey="Ishihara, Kazuhiko" sort="Ishihara, Kazuhiko" uniqKey="Ishihara K" first="Kazuhiko" last="Ishihara">Kazuhiko Ishihara</name><affiliation wicri:level="1"><nlm:aff id="I6">Department of Bioengineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8656, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Bioengineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8656</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="I8">Department of Materials Engineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8656, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Materials Engineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8656</wicri:regionArea></affiliation></author><author><name sortKey="Kitagawa, Yuko" sort="Kitagawa, Yuko" uniqKey="Kitagawa Y" first="Yuko" last="Kitagawa">Yuko Kitagawa</name><affiliation wicri:level="1"><nlm:aff id="I2">Department of Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo 160-8582, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo 160-8582</wicri:regionArea></affiliation></author></analytic><series><title level="j">BioMed Research International</title><idno type="ISSN">2314-6133</idno><idno type="eISSN">2314-6141</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><italic>Aim</italic>. The usefulness of photodynamic therapy (PDT) for treating sentinel lymph node (SLN) metastasis was evaluated.<italic> Materials and Methods</italic>. Verteporfin, a hydrophobic photosensitizer, forms a soluble aggregate with poly(2-methacryloyloxyethyl phosphorylcholine-<italic>co</italic>-<italic>n</italic>-butyl methacrylate) (PMB). The concentrations of verteporfin were determined by measuring the fluorescence emitted at 700 nm. Seven days after the inoculation of A431 cells at the forearm of BALB/c nude mice, PMB-verteporfin was injected at dorsum manus and 75 J of light energy was delivered for 1 minute. Fifty-three mice were randomly assigned to the combination of PMB-verteporfin injection and light exposure, light exposure alone, PMB-verteporfin injection alone, and no treatment groups. Ten days after PDT, brachial lymph nodes, which were considered as SLNs, were harvested and evaluated.<italic> Results</italic>. The concentration of verteporfin in SLN was significantly higher than other organs. The combination of PMB-verteporfin injection and light exposure group significantly reduced the SLN metastasis (13%) comparing with no treatment group (52%), light exposure alone group (57%), and PMB-verteporfin injection alone group (46%).<italic> Conclusions</italic>. These data suggested that PDT using PMB as a nanotransporter of verteporfin could be a minimally invasive treatment of SLN metastasis in breast cancer and represent a potential alternative procedure to SLNB.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Halsted, W S" uniqKey="Halsted W">W. S. Halsted</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Giuliano, A E" uniqKey="Giuliano A">A. E. Giuliano</name></author><author><name sortKey="Kirgan, D M" uniqKey="Kirgan D">D. M. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Biomed Res Int</journal-id><journal-id journal-id-type="iso-abbrev">Biomed Res Int</journal-id><journal-id journal-id-type="publisher-id">BMRI</journal-id><journal-title-group><journal-title>BioMed Research International</journal-title></journal-title-group><issn pub-type="ppub">2314-6133</issn><issn pub-type="epub">2314-6141</issn><publisher><publisher-name>Hindawi</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">28473989</article-id><article-id pub-id-type="pmc">5394349</article-id><article-id pub-id-type="doi">10.1155/2017/7412865</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title>The Noninvasive Treatment for Sentinel Lymph Node Metastasis by Photodynamic Therapy Using Phospholipid Polymer as a Nanotransporter of Verteporfin</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Shimada</surname><given-names>Kyosuke</given-names></name><xref ref-type="aff" rid="I1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Matsuda</surname><given-names>Sachiko</given-names></name><xref ref-type="aff" rid="I2"><sup>2</sup></xref><xref ref-type="aff" rid="I3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="false">http://orcid.org/0000-0002-1331-7053</contrib-id><name><surname>Jinno</surname><given-names>Hiromitsu</given-names></name><xref ref-type="aff" rid="I4"><sup>4</sup></xref><xref ref-type="corresp" rid="cor1"><sup>*</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kameyama</surname><given-names>Noriaki</given-names></name><xref ref-type="aff" rid="I5"><sup>5</sup></xref></contrib><contrib contrib-type="author"><name><surname>Konno</surname><given-names>Tomohiro</given-names></name><xref ref-type="aff" rid="I6"><sup>6</sup></xref></contrib><contrib contrib-type="author"><name><surname>Arai</surname><given-names>Tsunenori</given-names></name><xref ref-type="aff" rid="I7"><sup>7</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ishihara</surname><given-names>Kazuhiko</given-names></name><xref ref-type="aff" rid="I6"><sup>6</sup></xref><xref ref-type="aff" rid="I8"><sup>8</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kitagawa</surname><given-names>Yuko</given-names></name><xref ref-type="aff" rid="I2"><sup>2</sup></xref></contrib></contrib-group><aff id="I1"><sup>1</sup>Department of Breast Surgery, Kawasaki Municipal Ida Hospital, 2-27-1 Ida, Nakahara, Kawasaki, Kanagawa 211-0035, Japan</aff><aff id="I2"><sup>2</sup>Department of Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo 160-8582, Japan</aff><aff id="I3"><sup>3</sup>Endowed Chair in Cancer Research, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo 160-8582, Japan</aff><aff id="I4"><sup>4</sup>Department of Surgery, Teikyo University School of Medicine, 2-11-1, Kaga, Itabashi, Tokyo 173-8606, Japan</aff><aff id="I5"><sup>5</sup>Department of Surgery, Tachikawa Hospital, 4-2-22, Niishikicho, Tachikawa, Tokyo 190-8531, Japan</aff><aff id="I6"><sup>6</sup>Department of Bioengineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8656, Japan</aff><aff id="I7"><sup>7</sup>Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku, Yokohama, Kanagawa 223-8522, Japan</aff><aff id="I8"><sup>8</sup>Department of Materials Engineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8656, Japan</aff><author-notes><corresp id="cor1">*Hiromitsu Jinno: <email>jinnoh@dd.iij4u.or.jp</email></corresp><fn fn-type="other"><p>Academic Editor: Maurizio Battaglia Parodi</p></fn></author-notes><pub-date pub-type="ppub"><year>2017</year></pub-date><pub-date pub-type="epub"><day>3</day><month>4</month><year>2017</year></pub-date><volume>2017</volume><elocation-id>7412865</elocation-id><history><date date-type="received"><day>22</day><month>11</month><year>2016</year></date><date date-type="rev-recd"><day>10</day><month>2</month><year>2017</year></date><date date-type="accepted"><day>1</day><month>3</month><year>2017</year></date></history><permissions><copyright-statement>Copyright © 2017 Kyosuke Shimada et al.</copyright-statement><copyright-year>2017</copyright-year><license xlink:href="https://creativecommons.org/licenses/by/4.0/"><license-p>This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><abstract><p><italic>Aim</italic>. The usefulness of photodynamic therapy (PDT) for treating sentinel lymph node (SLN) metastasis was evaluated.<italic> Materials and Methods</italic>. Verteporfin, a hydrophobic photosensitizer, forms a soluble aggregate with poly(2-methacryloyloxyethyl phosphorylcholine-<italic>co</italic>-<italic>n</italic>-butyl methacrylate) (PMB). The concentrations of verteporfin were determined by measuring the fluorescence emitted at 700 nm. Seven days after the inoculation of A431 cells at the forearm of BALB/c nude mice, PMB-verteporfin was injected at dorsum manus and 75 J of light energy was delivered for 1 minute. Fifty-three mice were randomly assigned to the combination of PMB-verteporfin injection and light exposure, light exposure alone, PMB-verteporfin injection alone, and no treatment groups. Ten days after PDT, brachial lymph nodes, which were considered as SLNs, were harvested and evaluated.<italic> Results</italic>. The concentration of verteporfin in SLN was significantly higher than other organs. The combination of PMB-verteporfin injection and light exposure group significantly reduced the SLN metastasis (13%) comparing with no treatment group (52%), light exposure alone group (57%), and PMB-verteporfin injection alone group (46%).<italic> Conclusions</italic>. These data suggested that PDT using PMB as a nanotransporter of verteporfin could be a minimally invasive treatment of SLN metastasis in breast cancer and represent a potential alternative procedure to SLNB.</p></abstract><funding-group><award-group><funding-source xlink:href="http://dx.doi.org/10.13039/501100001700">Ministry of Education, Culture, Sports, Science and Technology</funding-source><award-id>2306</award-id></award-group></funding-group></article-meta></front><floats-group><fig id="fig1" orientation="portrait" position="float"><label>Figure 1</label><graphic xlink:href="BMRI2017-7412865.001"></graphic></fig><fig id="fig2" orientation="portrait" position="float"><label>Figure 2</label><caption><p>Stereoscopic fluorescence microscope images of metastatic sentinel lymph nodes.</p></caption><graphic xlink:href="BMRI2017-7412865.002"></graphic></fig><fig id="fig3" orientation="portrait" position="float"><label>Figure 3</label><caption><p>Nuclear disruption in SLN after PDT.</p></caption><graphic xlink:href="BMRI2017-7412865.003"></graphic></fig><fig id="fig4" orientation="portrait" position="float"><label>Figure 4</label><caption><p>Amount of verteporfin distributed in various tissues.</p></caption><graphic xlink:href="BMRI2017-7412865.004"></graphic></fig><fig id="fig5" orientation="portrait" position="float"><label>Figure 5</label><caption><p>Effect of PDT on SLN metastasis.</p></caption><graphic xlink:href="BMRI2017-7412865.005"></graphic></fig></floats-group></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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