Risk factors for lymphedema in breast cancer survivors, the Iowa Women's Health Study
Identifieur interne : 000129 ( PascalFrancis/Corpus ); précédent : 000128; suivant : 000130Risk factors for lymphedema in breast cancer survivors, the Iowa Women's Health Study
Auteurs : Rehana L. Ahmed ; Kathryn H. Schmitz ; Anna E. Prizment ; Aaron R. FolsomSource :
- Breast cancer research and treatment [ 0167-6806 ] ; 2011.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Risk factors for lymphedema and related arm symptoms in breast cancer (BC) survivors have not been examined using a large prospective population-based cohort. The Iowa Women's Health Study (IWHS) collected self-reported data for diagnosed lymphedema in 2004, and data for cancer diagnosis, treatment, behavioral and health characteristics between 1986 and 2003. We studied 1,287 women, aged 55-69 at baseline, who developed unilateral BC: n = 104 (8%) with diagnosed lymphedema, n = 475 (37%) with arm symptoms but without diagnosed lymphedema, and n = 708 without lymphedema. Age- and multivariate-adjusted logistic regression models examined risk factors for lymphedema and related arm symptoms (OR [95% confidence interval]). The mean time between BC and the 2004 survey was 8.1 ± 5.0 (mean ± SD) years. After multivariate adjustment, the following cancer characteristics were positively associated with lymphedema: tumor stage (regional vs. in situ: 3.92 [1.61-9.54]), number of excised nodes (highest vs. lowest quintile: 3.52 [1.32-9.34], Ptrend = 0.003), tumor-positive nodes (yes vs. no 2.12 [1.19, 3.79]), and adjuvant chemotherapy (yes vs. no: 3.05 [1.75-5.30]). Several health characteristics were positively associated with lymphedema: baseline body mass index (highest vs. lowest tertile: 3.24 [1.70-6.21]), waist and hip circumference, and general health (fair/poor vs. excellent: 3.44 [1.30-9.06]). Positive associations with arm symptoms were number of excised nodes (highest vs. lowest quintile: 2.38 [1.41-.03], Ptrend = 0.007), axillary radiation (yes vs. no: 1.72 [1.15-2.57]), and baseline general health (fair/poor vs. excellent: 4.27 [2.60-7.00]). In the IWHS, obesity, poorer general health, and markers of more advanced cancer were risk factors for lymphedema and related arm symptoms in BC survivors.
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Format Inist (serveur)
| NO : | PASCAL 12-0019486 INIST |
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| ET : | Risk factors for lymphedema in breast cancer survivors, the Iowa Women's Health Study |
| AU : | AHMED (Rehana L.); SCHMITZ (Kathryn H.); PRIZMENT (Anna E.); FOLSOM (Aaron R.) |
| AF : | Department of Dermatology, University of Minnesota, Mayo Mail Code 98, 420 Delaware Street SE/Minneapolis, MN 55455-0392/Etats-Unis (1 aut.); Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania, 921 Blockley Hall, 423 Guardian Drive/Philadelphia, PA 19104/Etats-Unis (2 aut.); Division of Epidemiology and Community Health, The University of Minnesota, 1300 S Second Street, Suite 300/Minneapolis, MN 55454/Etats-Unis (3 aut., 4 aut.) |
| DT : | Publication en série; Niveau analytique |
| SO : | Breast cancer research and treatment; ISSN 0167-6806; Coden BCTRD6; Pays-Bas; Da. 2011; Vol. 130; No. 3; Pp. 981-991; Bibl. 40 ref. |
| LA : | Anglais |
| EA : | Risk factors for lymphedema and related arm symptoms in breast cancer (BC) survivors have not been examined using a large prospective population-based cohort. The Iowa Women's Health Study (IWHS) collected self-reported data for diagnosed lymphedema in 2004, and data for cancer diagnosis, treatment, behavioral and health characteristics between 1986 and 2003. We studied 1,287 women, aged 55-69 at baseline, who developed unilateral BC: n = 104 (8%) with diagnosed lymphedema, n = 475 (37%) with arm symptoms but without diagnosed lymphedema, and n = 708 without lymphedema. Age- and multivariate-adjusted logistic regression models examined risk factors for lymphedema and related arm symptoms (OR [95% confidence interval]). The mean time between BC and the 2004 survey was 8.1 ± 5.0 (mean ± SD) years. After multivariate adjustment, the following cancer characteristics were positively associated with lymphedema: tumor stage (regional vs. in situ: 3.92 [1.61-9.54]), number of excised nodes (highest vs. lowest quintile: 3.52 [1.32-9.34], Ptrend = 0.003), tumor-positive nodes (yes vs. no 2.12 [1.19, 3.79]), and adjuvant chemotherapy (yes vs. no: 3.05 [1.75-5.30]). Several health characteristics were positively associated with lymphedema: baseline body mass index (highest vs. lowest tertile: 3.24 [1.70-6.21]), waist and hip circumference, and general health (fair/poor vs. excellent: 3.44 [1.30-9.06]). Positive associations with arm symptoms were number of excised nodes (highest vs. lowest quintile: 2.38 [1.41-.03], Ptrend = 0.007), axillary radiation (yes vs. no: 1.72 [1.15-2.57]), and baseline general health (fair/poor vs. excellent: 4.27 [2.60-7.00]). In the IWHS, obesity, poorer general health, and markers of more advanced cancer were risk factors for lymphedema and related arm symptoms in BC survivors. |
| CC : | 002B20E02; 002B12B04 |
| FD : | Facteur risque; Epidémiologie; Lymphoedème; Cancer du sein; Homme; Survivant; Iowa; Femelle; Adulte; Femme; Santé |
| FG : | Etats-Unis; Amérique du Nord; Amérique; Pathologie de l'appareil circulatoire; Pathologie des vaisseaux lymphatiques; Tumeur maligne; Cancer; Pathologie de la glande mammaire; Pathologie du sein |
| ED : | Risk factor; Epidemiology; Lymphedema; Breast cancer; Human; Survivor; Iowa; Female; Adult; Woman; Health |
| EG : | United States; North America; America; Cardiovascular disease; Lymphatic vessel disease; Malignant tumor; Cancer; Mammary gland diseases; Breast disease |
| SD : | Factor riesgo; Epidemiología; Linfedema; Cáncer del pecho; Hombre; Sobreviviente; Iowa; Hembra; Adulto; Mujer; Salud |
| LO : | INIST-20699.354000507339490280 |
| ID : | 12-0019486 |
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Schmitz</name><affiliation><inist:fA14 i1="02"><s1>Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania, 921 Blockley Hall, 423 Guardian Drive</s1><s2>Philadelphia, PA 19104</s2><s3>USA</s3><sZ>2 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Prizment, Anna E" sort="Prizment, Anna E" uniqKey="Prizment A" first="Anna E." last="Prizment">Anna E. Prizment</name><affiliation><inist:fA14 i1="03"><s1>Division of Epidemiology and Community Health, The University of Minnesota, 1300 S Second Street, Suite 300</s1><s2>Minneapolis, MN 55454</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Folsom, Aaron R" sort="Folsom, Aaron R" uniqKey="Folsom A" first="Aaron R." last="Folsom">Aaron R. Folsom</name><affiliation><inist:fA14 i1="03"><s1>Division of Epidemiology and Community Health, The University of Minnesota, 1300 S Second Street, Suite 300</s1><s2>Minneapolis, MN 55454</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">12-0019486</idno><date when="2011">2011</date><idno type="stanalyst">PASCAL 12-0019486 INIST</idno><idno type="RBID">Pascal:12-0019486</idno><idno type="wicri:Area/PascalFrancis/Corpus">000129</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Risk factors for lymphedema in breast cancer survivors, the Iowa Women's Health Study</title><author><name sortKey="Ahmed, Rehana L" sort="Ahmed, Rehana L" uniqKey="Ahmed R" first="Rehana L." last="Ahmed">Rehana L. Ahmed</name><affiliation><inist:fA14 i1="01"><s1>Department of Dermatology, University of Minnesota, Mayo Mail Code 98, 420 Delaware Street SE</s1><s2>Minneapolis, MN 55455-0392</s2><s3>USA</s3><sZ>1 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Schmitz, Kathryn H" sort="Schmitz, Kathryn H" uniqKey="Schmitz K" first="Kathryn H." last="Schmitz">Kathryn H. Schmitz</name><affiliation><inist:fA14 i1="02"><s1>Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania, 921 Blockley Hall, 423 Guardian Drive</s1><s2>Philadelphia, PA 19104</s2><s3>USA</s3><sZ>2 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Prizment, Anna E" sort="Prizment, Anna E" uniqKey="Prizment A" first="Anna E." last="Prizment">Anna E. Prizment</name><affiliation><inist:fA14 i1="03"><s1>Division of Epidemiology and Community Health, The University of Minnesota, 1300 S Second Street, Suite 300</s1><s2>Minneapolis, MN 55454</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Folsom, Aaron R" sort="Folsom, Aaron R" uniqKey="Folsom A" first="Aaron R." last="Folsom">Aaron R. Folsom</name><affiliation><inist:fA14 i1="03"><s1>Division of Epidemiology and Community Health, The University of Minnesota, 1300 S Second Street, Suite 300</s1><s2>Minneapolis, MN 55454</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14></affiliation></author></analytic><series><title level="j" type="main">Breast cancer research and treatment</title><title level="j" type="abbreviated">Breast cancer res. treat.</title><idno type="ISSN">0167-6806</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Breast cancer research and treatment</title><title level="j" type="abbreviated">Breast cancer res. treat.</title><idno type="ISSN">0167-6806</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Breast cancer</term><term>Epidemiology</term><term>Female</term><term>Health</term><term>Human</term><term>Iowa</term><term>Lymphedema</term><term>Risk factor</term><term>Survivor</term><term>Woman</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Facteur risque</term><term>Epidémiologie</term><term>Lymphoedème</term><term>Cancer du sein</term><term>Homme</term><term>Survivant</term><term>Iowa</term><term>Femelle</term><term>Adulte</term><term>Femme</term><term>Santé</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Risk factors for lymphedema and related arm symptoms in breast cancer (BC) survivors have not been examined using a large prospective population-based cohort. The Iowa Women's Health Study (IWHS) collected self-reported data for diagnosed lymphedema in 2004, and data for cancer diagnosis, treatment, behavioral and health characteristics between 1986 and 2003. We studied 1,287 women, aged 55-69 at baseline, who developed unilateral BC: n = 104 (8%) with diagnosed lymphedema, n = 475 (37%) with arm symptoms but without diagnosed lymphedema, and n = 708 without lymphedema. Age- and multivariate-adjusted logistic regression models examined risk factors for lymphedema and related arm symptoms (OR [95% confidence interval]). The mean time between BC and the 2004 survey was 8.1 ± 5.0 (mean ± SD) years. After multivariate adjustment, the following cancer characteristics were positively associated with lymphedema: tumor stage (regional vs. in situ: 3.92 [1.61-9.54]), number of excised nodes (highest vs. lowest quintile: 3.52 [1.32-9.34], P<sub>trend</sub> = 0.003), tumor-positive nodes (yes vs. no 2.12 [1.19, 3.79]), and adjuvant chemotherapy (yes vs. no: 3.05 [1.75-5.30]). Several health characteristics were positively associated with lymphedema: baseline body mass index (highest vs. lowest tertile: 3.24 [1.70-6.21]), waist and hip circumference, and general health (fair/poor vs. excellent: 3.44 [1.30-9.06]). Positive associations with arm symptoms were number of excised nodes (highest vs. lowest quintile: 2.38 [1.41-.03], P<sub>trend</sub> = 0.007), axillary radiation (yes vs. no: 1.72 [1.15-2.57]), and baseline general health (fair/poor vs. excellent: 4.27 [2.60-7.00]). In the IWHS, obesity, poorer general health, and markers of more advanced cancer were risk factors for lymphedema and related arm symptoms in BC survivors.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0167-6806</s0></fA01><fA02 i1="01"><s0>BCTRD6</s0></fA02><fA03 i2="1"><s0>Breast cancer res. treat.</s0></fA03><fA05><s2>130</s2></fA05><fA06><s2>3</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Risk factors for lymphedema in breast cancer survivors, the Iowa Women's Health Study</s1></fA08><fA11 i1="01" i2="1"><s1>AHMED (Rehana L.)</s1></fA11><fA11 i1="02" i2="1"><s1>SCHMITZ (Kathryn H.)</s1></fA11><fA11 i1="03" i2="1"><s1>PRIZMENT (Anna E.)</s1></fA11><fA11 i1="04" i2="1"><s1>FOLSOM (Aaron R.)</s1></fA11><fA14 i1="01"><s1>Department of Dermatology, University of Minnesota, Mayo Mail Code 98, 420 Delaware Street SE</s1><s2>Minneapolis, MN 55455-0392</s2><s3>USA</s3><sZ>1 aut.</sZ></fA14><fA14 i1="02"><s1>Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania, 921 Blockley Hall, 423 Guardian Drive</s1><s2>Philadelphia, PA 19104</s2><s3>USA</s3><sZ>2 aut.</sZ></fA14><fA14 i1="03"><s1>Division of Epidemiology and Community Health, The University of Minnesota, 1300 S Second Street, Suite 300</s1><s2>Minneapolis, MN 55454</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ></fA14><fA20><s1>981-991</s1></fA20><fA21><s1>2011</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>20699</s2><s5>354000507339490280</s5></fA43><fA44><s0>0000</s0><s1>© 2012 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>40 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>12-0019486</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Breast cancer research and treatment</s0></fA64><fA66 i1="01"><s0>NLD</s0></fA66><fC01 i1="01" l="ENG"><s0>Risk factors for lymphedema and related arm symptoms in breast cancer (BC) survivors have not been examined using a large prospective population-based cohort. The Iowa Women's Health Study (IWHS) collected self-reported data for diagnosed lymphedema in 2004, and data for cancer diagnosis, treatment, behavioral and health characteristics between 1986 and 2003. We studied 1,287 women, aged 55-69 at baseline, who developed unilateral BC: n = 104 (8%) with diagnosed lymphedema, n = 475 (37%) with arm symptoms but without diagnosed lymphedema, and n = 708 without lymphedema. Age- and multivariate-adjusted logistic regression models examined risk factors for lymphedema and related arm symptoms (OR [95% confidence interval]). The mean time between BC and the 2004 survey was 8.1 ± 5.0 (mean ± SD) years. After multivariate adjustment, the following cancer characteristics were positively associated with lymphedema: tumor stage (regional vs. in situ: 3.92 [1.61-9.54]), number of excised nodes (highest vs. lowest quintile: 3.52 [1.32-9.34], P<sub>trend</sub> = 0.003), tumor-positive nodes (yes vs. no 2.12 [1.19, 3.79]), and adjuvant chemotherapy (yes vs. no: 3.05 [1.75-5.30]). Several health characteristics were positively associated with lymphedema: baseline body mass index (highest vs. lowest tertile: 3.24 [1.70-6.21]), waist and hip circumference, and general health (fair/poor vs. excellent: 3.44 [1.30-9.06]). Positive associations with arm symptoms were number of excised nodes (highest vs. lowest quintile: 2.38 [1.41-.03], P<sub>trend</sub> = 0.007), axillary radiation (yes vs. no: 1.72 [1.15-2.57]), and baseline general health (fair/poor vs. excellent: 4.27 [2.60-7.00]). In the IWHS, obesity, poorer general health, and markers of more advanced cancer were risk factors for lymphedema and related arm symptoms in BC survivors.</s0></fC01><fC02 i1="01" i2="X"><s0>002B20E02</s0></fC02><fC02 i1="02" i2="X"><s0>002B12B04</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Facteur risque</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Risk factor</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Factor riesgo</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Epidémiologie</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Epidemiology</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Epidemiología</s0><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Lymphoedème</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Lymphedema</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Linfedema</s0><s5>03</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Cancer du sein</s0><s2>NM</s2><s5>04</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Breast cancer</s0><s2>NM</s2><s5>04</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Cáncer del pecho</s0><s2>NM</s2><s5>04</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Homme</s0><s5>05</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Human</s0><s5>05</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Hombre</s0><s5>05</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Survivant</s0><s5>06</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Survivor</s0><s5>06</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Sobreviviente</s0><s5>06</s5></fC03><fC03 i1="07" i2="X" l="FRE"><s0>Iowa</s0><s2>NG</s2><s5>07</s5></fC03><fC03 i1="07" i2="X" l="ENG"><s0>Iowa</s0><s2>NG</s2><s5>07</s5></fC03><fC03 i1="07" i2="X" l="SPA"><s0>Iowa</s0><s2>NG</s2><s5>07</s5></fC03><fC03 i1="08" i2="X" l="FRE"><s0>Femelle</s0><s5>08</s5></fC03><fC03 i1="08" i2="X" l="ENG"><s0>Female</s0><s5>08</s5></fC03><fC03 i1="08" i2="X" l="SPA"><s0>Hembra</s0><s5>08</s5></fC03><fC03 i1="09" i2="X" l="FRE"><s0>Adulte</s0><s5>09</s5></fC03><fC03 i1="09" i2="X" l="ENG"><s0>Adult</s0><s5>09</s5></fC03><fC03 i1="09" i2="X" l="SPA"><s0>Adulto</s0><s5>09</s5></fC03><fC03 i1="10" i2="X" l="FRE"><s0>Femme</s0><s5>10</s5></fC03><fC03 i1="10" i2="X" l="ENG"><s0>Woman</s0><s5>10</s5></fC03><fC03 i1="10" i2="X" l="SPA"><s0>Mujer</s0><s5>10</s5></fC03><fC03 i1="11" i2="X" l="FRE"><s0>Santé</s0><s5>11</s5></fC03><fC03 i1="11" i2="X" l="ENG"><s0>Health</s0><s5>11</s5></fC03><fC03 i1="11" i2="X" l="SPA"><s0>Salud</s0><s5>11</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Etats-Unis</s0><s2>NG</s2></fC07><fC07 i1="01" i2="X" l="ENG"><s0>United States</s0><s2>NG</s2></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Estados Unidos</s0><s2>NG</s2></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Amérique du Nord</s0><s2>NG</s2></fC07><fC07 i1="02" i2="X" l="ENG"><s0>North America</s0><s2>NG</s2></fC07><fC07 i1="02" i2="X" l="SPA"><s0>America del norte</s0><s2>NG</s2></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Amérique</s0><s2>NG</s2></fC07><fC07 i1="03" i2="X" l="ENG"><s0>America</s0><s2>NG</s2></fC07><fC07 i1="03" i2="X" l="SPA"><s0>America</s0><s2>NG</s2></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Pathologie de l'appareil circulatoire</s0><s5>37</s5></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Cardiovascular disease</s0><s5>37</s5></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Aparato circulatorio patología</s0><s5>37</s5></fC07><fC07 i1="05" i2="X" l="FRE"><s0>Pathologie des vaisseaux lymphatiques</s0><s5>38</s5></fC07><fC07 i1="05" i2="X" l="ENG"><s0>Lymphatic vessel disease</s0><s5>38</s5></fC07><fC07 i1="05" i2="X" l="SPA"><s0>Linfático patología</s0><s5>38</s5></fC07><fC07 i1="06" i2="X" l="FRE"><s0>Tumeur maligne</s0><s2>NM</s2><s5>39</s5></fC07><fC07 i1="06" i2="X" l="ENG"><s0>Malignant tumor</s0><s2>NM</s2><s5>39</s5></fC07><fC07 i1="06" i2="X" l="SPA"><s0>Tumor maligno</s0><s2>NM</s2><s5>39</s5></fC07><fC07 i1="07" i2="X" l="FRE"><s0>Cancer</s0><s2>NM</s2></fC07><fC07 i1="07" i2="X" l="ENG"><s0>Cancer</s0><s2>NM</s2></fC07><fC07 i1="07" i2="X" l="SPA"><s0>Cáncer</s0><s2>NM</s2></fC07><fC07 i1="08" i2="X" l="FRE"><s0>Pathologie de la glande mammaire</s0><s2>NM</s2><s5>40</s5></fC07><fC07 i1="08" i2="X" l="ENG"><s0>Mammary gland diseases</s0><s2>NM</s2><s5>40</s5></fC07><fC07 i1="08" i2="X" l="SPA"><s0>Glándula mamaria patología</s0><s2>NM</s2><s5>40</s5></fC07><fC07 i1="09" i2="X" l="FRE"><s0>Pathologie du sein</s0><s2>NM</s2><s5>41</s5></fC07><fC07 i1="09" i2="X" l="ENG"><s0>Breast disease</s0><s2>NM</s2><s5>41</s5></fC07><fC07 i1="09" i2="X" l="SPA"><s0>Seno patología</s0><s2>NM</s2><s5>41</s5></fC07><fN21><s1>002</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard><server><NO>PASCAL 12-0019486 INIST</NO><ET>Risk factors for lymphedema in breast cancer survivors, the Iowa Women's Health Study</ET><AU>AHMED (Rehana L.); SCHMITZ (Kathryn H.); PRIZMENT (Anna E.); FOLSOM (Aaron R.)</AU><AF>Department of Dermatology, University of Minnesota, Mayo Mail Code 98, 420 Delaware Street SE/Minneapolis, MN 55455-0392/Etats-Unis (1 aut.); Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania, 921 Blockley Hall, 423 Guardian Drive/Philadelphia, PA 19104/Etats-Unis (2 aut.); Division of Epidemiology and Community Health, The University of Minnesota, 1300 S Second Street, Suite 300/Minneapolis, MN 55454/Etats-Unis (3 aut., 4 aut.)</AF><DT>Publication en série; Niveau analytique</DT><SO>Breast cancer research and treatment; ISSN 0167-6806; Coden BCTRD6; Pays-Bas; Da. 2011; Vol. 130; No. 3; Pp. 981-991; Bibl. 40 ref.</SO><LA>Anglais</LA><EA>Risk factors for lymphedema and related arm symptoms in breast cancer (BC) survivors have not been examined using a large prospective population-based cohort. The Iowa Women's Health Study (IWHS) collected self-reported data for diagnosed lymphedema in 2004, and data for cancer diagnosis, treatment, behavioral and health characteristics between 1986 and 2003. We studied 1,287 women, aged 55-69 at baseline, who developed unilateral BC: n = 104 (8%) with diagnosed lymphedema, n = 475 (37%) with arm symptoms but without diagnosed lymphedema, and n = 708 without lymphedema. Age- and multivariate-adjusted logistic regression models examined risk factors for lymphedema and related arm symptoms (OR [95% confidence interval]). The mean time between BC and the 2004 survey was 8.1 ± 5.0 (mean ± SD) years. After multivariate adjustment, the following cancer characteristics were positively associated with lymphedema: tumor stage (regional vs. in situ: 3.92 [1.61-9.54]), number of excised nodes (highest vs. lowest quintile: 3.52 [1.32-9.34], P<sub>trend</sub> = 0.003), tumor-positive nodes (yes vs. no 2.12 [1.19, 3.79]), and adjuvant chemotherapy (yes vs. no: 3.05 [1.75-5.30]). Several health characteristics were positively associated with lymphedema: baseline body mass index (highest vs. lowest tertile: 3.24 [1.70-6.21]), waist and hip circumference, and general health (fair/poor vs. excellent: 3.44 [1.30-9.06]). Positive associations with arm symptoms were number of excised nodes (highest vs. lowest quintile: 2.38 [1.41-.03], P<sub>trend</sub> = 0.007), axillary radiation (yes vs. no: 1.72 [1.15-2.57]), and baseline general health (fair/poor vs. excellent: 4.27 [2.60-7.00]). In the IWHS, obesity, poorer general health, and markers of more advanced cancer were risk factors for lymphedema and related arm symptoms in BC survivors.</EA><CC>002B20E02; 002B12B04</CC><FD>Facteur risque; Epidémiologie; Lymphoedème; Cancer du sein; Homme; Survivant; Iowa; Femelle; Adulte; Femme; Santé</FD><FG>Etats-Unis; Amérique du Nord; Amérique; Pathologie de l'appareil circulatoire; Pathologie des vaisseaux lymphatiques; Tumeur maligne; Cancer; Pathologie de la glande mammaire; Pathologie du sein</FG><ED>Risk factor; Epidemiology; Lymphedema; Breast cancer; Human; Survivor; Iowa; Female; Adult; Woman; Health</ED><EG>United States; North America; America; Cardiovascular disease; Lymphatic vessel disease; Malignant tumor; Cancer; Mammary gland diseases; Breast disease</EG><SD>Factor riesgo; Epidemiología; Linfedema; Cáncer del pecho; Hombre; Sobreviviente; Iowa; Hembra; Adulto; Mujer; Salud</SD><LO>INIST-20699.354000507339490280</LO><ID>12-0019486</ID></server></inist></record>Pour manipuler ce document sous Unix (Dilib)
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