Forearm blood flow measured by venous occlusion plethysmography in healthy subjects and in women with postmastectomy oedema
Identifieur interne : 000A86 ( PascalFrancis/Checkpoint ); précédent : 000A85; suivant : 000A87Forearm blood flow measured by venous occlusion plethysmography in healthy subjects and in women with postmastectomy oedema
Auteurs : A. W. B. Stanton [Royaume-Uni] ; B. Holroyd [Royaume-Uni] ; J. W. Northfield [Royaume-Uni] ; J. R. Levick [Royaume-Uni] ; Peter Mortimer (dermatologue) [Royaume-Uni]Source :
- Vascular medicine : (London) [ 1358-863X ] ; 1998.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
Abstract
A chronic swelling of the arm may develop following damage to axillary lymph vessels during breast cancer treatment. Certain unusual pathophysiological features of postmastectomy oedema indicate that factors additional to lymphatic damage are important. One factor postulated previously is a haemodynamic abnormality. Forearm blood flow was therefore measured by venous occlusion plethysmography using both a conventional mercury strain gauge and a newer optical volumeter (Perometer®). The latter was initially assessed in healthy subjects. When forearm blood flow was measured using the two methods simultaneously, the strain gauge and Perometer® did not differ significantly for healthy or oedematous arms. Dominant and non-dominant arm blood flow in healthy subjects was similar but with greater variation between sides with the Perometer®. Using the strain gauge, blood flow in the oedematous arm (2.51±1.33 ml/100 ml per min) was significantly lower than in the opposite unaffected arm (3.77±2.29 ml/100 ml per min; p = 0.026). The Perometer® results showed a similar but non-significant trend (p = 0.105). Taking into account the greater limb volume on the affected side, total forearm blood flow was essentially the same in each arm (unaffected: 40.72 ± 28.70 ml/min; oedematous: 41.78 ± 22.11 ml/min). The reduced blood flow per unit volume of arm was therefore likely to be due to a simple 'dilution' effect of the increase in volume. The results indicate that it is unlikely that raised blood flow contributes to oedema formation, contrary to the haemodynamic concept.
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Levick</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Department of Physiology, St George's Hospital Medical School</s1><s2>London</s2><s3>GBR</s3><sZ>4 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Mortimer, P S" sort="Mortimer, P S" uniqKey="Mortimer P" first="P. 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W. B." last="Stanton">A. W. B. Stanton</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Medicine, Division of Physiological Medicine (Dermatology), St George's Hospital Medical School</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Holroyd, B" sort="Holroyd, B" uniqKey="Holroyd B" first="B." last="Holroyd">B. Holroyd</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>St George's Hospital Medical School</s1><s2>London</s2><s3>GBR</s3><sZ>2 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Northfield, J W" sort="Northfield, J W" uniqKey="Northfield J" first="J. W." last="Northfield">J. W. Northfield</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Mayday Hospital</s1><s2>Croydon</s2><s3>GBR</s3><sZ>3 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Mayday Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Levick, J R" sort="Levick, J R" uniqKey="Levick J" first="J. R." last="Levick">J. R. Levick</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Department of Physiology, St George's Hospital Medical School</s1><s2>London</s2><s3>GBR</s3><sZ>4 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Mortimer, P S" sort="Mortimer, P S" uniqKey="Mortimer P" first="P. S." last="Mortimer">Peter Mortimer (dermatologue)</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Medicine, Division of Physiological Medicine (Dermatology), St George's Hospital Medical School</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">Université de Londres</orgName></affiliation></author></analytic><series><title level="j" type="main">Vascular medicine : (London)</title><title level="j" type="abbreviated">Vasc. med. : (Lond.)</title><idno type="ISSN">1358-863X</idno><imprint><date when="1998">1998</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Vascular medicine : (London)</title><title level="j" type="abbreviated">Vasc. med. : (Lond.)</title><idno type="ISSN">1358-863X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Blood flow</term><term>Complication</term><term>Exploration</term><term>Female</term><term>Forearm</term><term>Human</term><term>Lymphedema</term><term>Mammary gland</term><term>Plethysmography</term><term>Sex</term><term>Surgical resection</term><term>Technique</term><term>Treatment</term><term>Upper limb</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Lymphoedème</term><term>Membre supérieur</term><term>Pléthysmographie</term><term>Débit sanguin</term><term>Avant bras</term><term>Résection chirurgicale</term><term>Glande mammaire</term><term>Technique</term><term>Traitement</term><term>Complication</term><term>Exploration</term><term>Homme</term><term>Sexe</term><term>Femelle</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A chronic swelling of the arm may develop following damage to axillary lymph vessels during breast cancer treatment. Certain unusual pathophysiological features of postmastectomy oedema indicate that factors additional to lymphatic damage are important. One factor postulated previously is a haemodynamic abnormality. Forearm blood flow was therefore measured by venous occlusion plethysmography using both a conventional mercury strain gauge and a newer optical volumeter (Perometer®). The latter was initially assessed in healthy subjects. When forearm blood flow was measured using the two methods simultaneously, the strain gauge and Perometer® did not differ significantly for healthy or oedematous arms. Dominant and non-dominant arm blood flow in healthy subjects was similar but with greater variation between sides with the Perometer®. Using the strain gauge, blood flow in the oedematous arm (2.51±1.33 ml/100 ml per min) was significantly lower than in the opposite unaffected arm (3.77±2.29 ml/100 ml per min; p = 0.026). The Perometer® results showed a similar but non-significant trend (p = 0.105). Taking into account the greater limb volume on the affected side, total forearm blood flow was essentially the same in each arm (unaffected: 40.72 ± 28.70 ml/min; oedematous: 41.78 ± 22.11 ml/min). The reduced blood flow per unit volume of arm was therefore likely to be due to a simple 'dilution' effect of the increase in volume. The results indicate that it is unlikely that raised blood flow contributes to oedema formation, contrary to the haemodynamic concept.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>1358-863X</s0></fA01><fA03 i2="1"><s0>Vasc. med. : (Lond.)</s0></fA03><fA05><s2>3</s2></fA05><fA06><s2>1</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Forearm blood flow measured by venous occlusion plethysmography in healthy subjects and in women with postmastectomy oedema</s1></fA08><fA11 i1="01" i2="1"><s1>STANTON (A. W. B.)</s1></fA11><fA11 i1="02" i2="1"><s1>HOLROYD (B.)</s1></fA11><fA11 i1="03" i2="1"><s1>NORTHFIELD (J. W.)</s1></fA11><fA11 i1="04" i2="1"><s1>LEVICK (J. R.)</s1></fA11><fA11 i1="05" i2="1"><s1>MORTIMER (P. S.)</s1></fA11><fA14 i1="01"><s1>Department of Medicine, Division of Physiological Medicine (Dermatology), St George's Hospital Medical School</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ></fA14><fA14 i1="02"><s1>St George's Hospital Medical School</s1><s2>London</s2><s3>GBR</s3><sZ>2 aut.</sZ></fA14><fA14 i1="03"><s1>Mayday Hospital</s1><s2>Croydon</s2><s3>GBR</s3><sZ>3 aut.</sZ></fA14><fA14 i1="04"><s1>Department of Physiology, St George's Hospital Medical School</s1><s2>London</s2><s3>GBR</s3><sZ>4 aut.</sZ></fA14><fA20><s1>3-8</s1></fA20><fA21><s1>1998</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>26454</s2><s5>354000076425570010</s5></fA43><fA44><s0>0000</s0><s1>© 1998 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>19 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>98-0308089</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i2="1"><s0>Vascular medicine : (London)</s0></fA64><fA66 i1="01"><s0>GBR</s0></fA66><fC01 i1="01" l="ENG"><s0>A chronic swelling of the arm may develop following damage to axillary lymph vessels during breast cancer treatment. Certain unusual pathophysiological features of postmastectomy oedema indicate that factors additional to lymphatic damage are important. One factor postulated previously is a haemodynamic abnormality. Forearm blood flow was therefore measured by venous occlusion plethysmography using both a conventional mercury strain gauge and a newer optical volumeter (Perometer®). The latter was initially assessed in healthy subjects. When forearm blood flow was measured using the two methods simultaneously, the strain gauge and Perometer® did not differ significantly for healthy or oedematous arms. Dominant and non-dominant arm blood flow in healthy subjects was similar but with greater variation between sides with the Perometer®. Using the strain gauge, blood flow in the oedematous arm (2.51±1.33 ml/100 ml per min) was significantly lower than in the opposite unaffected arm (3.77±2.29 ml/100 ml per min; p = 0.026). The Perometer® results showed a similar but non-significant trend (p = 0.105). Taking into account the greater limb volume on the affected side, total forearm blood flow was essentially the same in each arm (unaffected: 40.72 ± 28.70 ml/min; oedematous: 41.78 ± 22.11 ml/min). The reduced blood flow per unit volume of arm was therefore likely to be due to a simple 'dilution' effect of the increase in volume. 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W. B." last="Stanton">A. W. B. Stanton</name></region><name sortKey="Holroyd, B" sort="Holroyd, B" uniqKey="Holroyd B" first="B." last="Holroyd">B. Holroyd</name><name sortKey="Levick, J R" sort="Levick, J R" uniqKey="Levick J" first="J. R." last="Levick">J. R. Levick</name><name sortKey="Mortimer, P S" sort="Mortimer, P S" uniqKey="Mortimer P" first="P. S." last="Mortimer">Peter Mortimer (dermatologue)</name><name sortKey="Northfield, J W" sort="Northfield, J W" uniqKey="Northfield J" first="J. W." last="Northfield">J. W. Northfield</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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