Bancroftian filariasis in Haiti: preliminary characterization of the immunological responsiveness of microfilaremic individuals.
Identifieur interne : 009668 ( Ncbi/Merge ); précédent : 009667; suivant : 009669Bancroftian filariasis in Haiti: preliminary characterization of the immunological responsiveness of microfilaremic individuals.
Auteurs : P J Lammie ; L E Leiva ; A J Ruff ; M L Eberhard ; R C Lowrie ; S P KatzSource :
- The American journal of tropical medicine and hygiene [ 0002-9637 ] ; 1988.
Descripteurs français
- KwdFr :
- Activation des lymphocytes, Agranulocytes (immunologie), Animaux, Anticorps antihelminthe (biosynthèse), Antigènes d'helminthe (immunologie), Brugia (immunologie), Filariose lymphatique (immunologie), Filarioses (immunologie), Haïti, Humains, Immunité cellulaire, Microfilaria (immunologie), Wuchereria bancrofti (immunologie).
- MESH :
- biosynthèse : Anticorps antihelminthe.
- immunologie : Agranulocytes, Antigènes d'helminthe, Brugia, Filariose lymphatique, Filarioses, Microfilaria, Wuchereria bancrofti.
- Activation des lymphocytes, Animaux, Haïti, Humains, Immunité cellulaire.
English descriptors
- KwdEn :
- Animals, Antibodies, Helminth (biosynthesis), Antigens, Helminth (immunology), Brugia (immunology), Elephantiasis, Filarial (immunology), Filariasis (immunology), Haiti, Humans, Immunity, Cellular, Leukocytes, Mononuclear (immunology), Lymphocyte Activation, Microfilariae (immunology), Wuchereria bancrofti (immunology).
- MESH :
- chemical , biosynthesis : Antibodies, Helminth.
- chemical , immunology : Antigens, Helminth.
- immunology : Brugia, Elephantiasis, Filarial, Filariasis, Leukocytes, Mononuclear, Microfilariae, Wuchereria bancrofti.
- Animals, Haiti, Humans, Immunity, Cellular, Lymphocyte Activation.
Abstract
Patent infections with the lymphatic filariae, Wuchereria bancrofti and Brugia malayi, are associated with suppressed in vitro cellular responsiveness to filarial antigens. In studies of bancroftian filariasis in Haiti, a significant number of microfilaremic individuals can be characterized as "responders" to filarial antigens. Cells from 37/74 untreated microfilaremic subjects responded to B. pahangi antigen (stimulation ratio greater than 2) as detected by in vitro blastogenesis. A comparison of responders to nonresponders revealed a significant difference in mean B. pahangi reactivity (15,822 vs. 4,538 cpm, P less than 0.001), but no significant differences with respect to age, microfilaremia, PPD or PHA reactivity, or B. pahangi-specific antibody levels. Subtle differences may exist between these groups with respect to recognition of specific antigens on Western blots.
PubMed: 3277457
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Bancroftian filariasis in Haiti: preliminary characterization of the immunological responsiveness of microfilaremic individuals.</title><author><name sortKey="Lammie, P J" sort="Lammie, P J" uniqKey="Lammie P" first="P J" last="Lammie">P J Lammie</name><affiliation><nlm:affiliation>Department of Microbiology, Immunology and Parasitology, Louisiana State University Medical Center, New Orleans 70112.</nlm:affiliation><wicri:noCountry code="subField">New Orleans 70112</wicri:noCountry></affiliation></author><author><name sortKey="Leiva, L E" sort="Leiva, L E" uniqKey="Leiva L" first="L E" last="Leiva">L E Leiva</name></author><author><name sortKey="Ruff, A J" sort="Ruff, A J" uniqKey="Ruff A" first="A J" last="Ruff">A J Ruff</name></author><author><name sortKey="Eberhard, M L" sort="Eberhard, M L" uniqKey="Eberhard M" first="M L" last="Eberhard">M L Eberhard</name></author><author><name sortKey="Lowrie, R C" sort="Lowrie, R C" uniqKey="Lowrie R" first="R C" last="Lowrie">R C Lowrie</name></author><author><name sortKey="Katz, S P" sort="Katz, S P" uniqKey="Katz S" first="S P" last="Katz">S P Katz</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1988">1988</date><idno type="RBID">pubmed:3277457</idno><idno type="pmid">3277457</idno><idno type="wicri:Area/PubMed/Corpus">006263</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">006263</idno><idno type="wicri:Area/PubMed/Curation">006263</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">006263</idno><idno type="wicri:Area/PubMed/Checkpoint">006263</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">006263</idno><idno type="wicri:Area/Ncbi/Merge">009668</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Bancroftian filariasis in Haiti: preliminary characterization of the immunological responsiveness of microfilaremic individuals.</title><author><name sortKey="Lammie, P J" sort="Lammie, P J" uniqKey="Lammie P" first="P J" last="Lammie">P J Lammie</name><affiliation><nlm:affiliation>Department of Microbiology, Immunology and Parasitology, Louisiana State University Medical Center, New Orleans 70112.</nlm:affiliation><wicri:noCountry code="subField">New Orleans 70112</wicri:noCountry></affiliation></author><author><name sortKey="Leiva, L E" sort="Leiva, L E" uniqKey="Leiva L" first="L E" last="Leiva">L E Leiva</name></author><author><name sortKey="Ruff, A J" sort="Ruff, A J" uniqKey="Ruff A" first="A J" last="Ruff">A J Ruff</name></author><author><name sortKey="Eberhard, M L" sort="Eberhard, M L" uniqKey="Eberhard M" first="M L" last="Eberhard">M L Eberhard</name></author><author><name sortKey="Lowrie, R C" sort="Lowrie, R C" uniqKey="Lowrie R" first="R C" last="Lowrie">R C Lowrie</name></author><author><name sortKey="Katz, S P" sort="Katz, S P" uniqKey="Katz S" first="S P" last="Katz">S P Katz</name></author></analytic><series><title level="j">The American journal of tropical medicine and hygiene</title><idno type="ISSN">0002-9637</idno><imprint><date when="1988" type="published">1988</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antibodies, Helminth (biosynthesis)</term><term>Antigens, Helminth (immunology)</term><term>Brugia (immunology)</term><term>Elephantiasis, Filarial (immunology)</term><term>Filariasis (immunology)</term><term>Haiti</term><term>Humans</term><term>Immunity, Cellular</term><term>Leukocytes, Mononuclear (immunology)</term><term>Lymphocyte Activation</term><term>Microfilariae (immunology)</term><term>Wuchereria bancrofti (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Activation des lymphocytes</term><term>Agranulocytes (immunologie)</term><term>Animaux</term><term>Anticorps antihelminthe (biosynthèse)</term><term>Antigènes d'helminthe (immunologie)</term><term>Brugia (immunologie)</term><term>Filariose lymphatique (immunologie)</term><term>Filarioses (immunologie)</term><term>Haïti</term><term>Humains</term><term>Immunité cellulaire</term><term>Microfilaria (immunologie)</term><term>Wuchereria bancrofti (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Antibodies, Helminth</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antigens, Helminth</term></keywords><keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Anticorps antihelminthe</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Agranulocytes</term><term>Antigènes d'helminthe</term><term>Brugia</term><term>Filariose lymphatique</term><term>Filarioses</term><term>Microfilaria</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Brugia</term><term>Elephantiasis, Filarial</term><term>Filariasis</term><term>Leukocytes, Mononuclear</term><term>Microfilariae</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Haiti</term><term>Humans</term><term>Immunity, Cellular</term><term>Lymphocyte Activation</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Activation des lymphocytes</term><term>Animaux</term><term>Haïti</term><term>Humains</term><term>Immunité cellulaire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Patent infections with the lymphatic filariae, Wuchereria bancrofti and Brugia malayi, are associated with suppressed in vitro cellular responsiveness to filarial antigens. In studies of bancroftian filariasis in Haiti, a significant number of microfilaremic individuals can be characterized as "responders" to filarial antigens. Cells from 37/74 untreated microfilaremic subjects responded to B. pahangi antigen (stimulation ratio greater than 2) as detected by in vitro blastogenesis. A comparison of responders to nonresponders revealed a significant difference in mean B. pahangi reactivity (15,822 vs. 4,538 cpm, P less than 0.001), but no significant differences with respect to age, microfilaremia, PPD or PHA reactivity, or B. pahangi-specific antibody levels. Subtle differences may exist between these groups with respect to recognition of specific antigens on Western blots.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">3277457</PMID><DateCreated><Year>1988</Year><Month>03</Month><Day>02</Day></DateCreated><DateCompleted><Year>1988</Year><Month>03</Month><Day>02</Day></DateCompleted><DateRevised><Year>2016</Year><Month>11</Month><Day>23</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0002-9637</ISSN><JournalIssue CitedMedium="Print"><Volume>38</Volume><Issue>1</Issue><PubDate><Year>1988</Year><Month>Jan</Month></PubDate></JournalIssue><Title>The American journal of tropical medicine and hygiene</Title><ISOAbbreviation>Am. J. Trop. Med. Hyg.</ISOAbbreviation></Journal><ArticleTitle>Bancroftian filariasis in Haiti: preliminary characterization of the immunological responsiveness of microfilaremic individuals.</ArticleTitle><Pagination><MedlinePgn>125-9</MedlinePgn></Pagination><Abstract><AbstractText>Patent infections with the lymphatic filariae, Wuchereria bancrofti and Brugia malayi, are associated with suppressed in vitro cellular responsiveness to filarial antigens. In studies of bancroftian filariasis in Haiti, a significant number of microfilaremic individuals can be characterized as "responders" to filarial antigens. Cells from 37/74 untreated microfilaremic subjects responded to B. pahangi antigen (stimulation ratio greater than 2) as detected by in vitro blastogenesis. A comparison of responders to nonresponders revealed a significant difference in mean B. pahangi reactivity (15,822 vs. 4,538 cpm, P less than 0.001), but no significant differences with respect to age, microfilaremia, PPD or PHA reactivity, or B. pahangi-specific antibody levels. Subtle differences may exist between these groups with respect to recognition of specific antigens on Western blots.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lammie</LastName><ForeName>P J</ForeName><Initials>PJ</Initials><AffiliationInfo><Affiliation>Department of Microbiology, Immunology and Parasitology, Louisiana State University Medical Center, New Orleans 70112.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Leiva</LastName><ForeName>L E</ForeName><Initials>LE</Initials></Author><Author ValidYN="Y"><LastName>Ruff</LastName><ForeName>A J</ForeName><Initials>AJ</Initials></Author><Author ValidYN="Y"><LastName>Eberhard</LastName><ForeName>M L</ForeName><Initials>ML</Initials></Author><Author ValidYN="Y"><LastName>Lowrie</LastName><ForeName>R C</ForeName><Initials>RC</Initials><Suffix>Jr</Suffix></Author><Author ValidYN="Y"><LastName>Katz</LastName><ForeName>S P</ForeName><Initials>SP</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>AI-16315</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013487">Research Support, U.S. Gov't, P.H.S.</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Am J Trop Med Hyg</MedlineTA><NlmUniqueID>0370507</NlmUniqueID><ISSNLinking>0002-9637</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000909">Antibodies, Helminth</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000947">Antigens, Helminth</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000909" MajorTopicYN="N">Antibodies, Helminth</DescriptorName><QualifierName UI="Q000096" MajorTopicYN="N">biosynthesis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000947" MajorTopicYN="N">Antigens, Helminth</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002009" MajorTopicYN="N">Brugia</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004605" MajorTopicYN="N">Elephantiasis, Filarial</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005368" MajorTopicYN="N">Filariasis</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006205" MajorTopicYN="N">Haiti</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007111" MajorTopicYN="N">Immunity, Cellular</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007963" MajorTopicYN="N">Leukocytes, Mononuclear</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008213" MajorTopicYN="N">Lymphocyte Activation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008842" MajorTopicYN="N">Microfilariae</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014958" MajorTopicYN="N">Wuchereria bancrofti</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1988</Year><Month>1</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2001</Year><Month>3</Month><Day>28</Day><Hour>10</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1988</Year><Month>1</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">3277457</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list></list><tree><noCountry><name sortKey="Eberhard, M L" sort="Eberhard, M L" uniqKey="Eberhard M" first="M L" last="Eberhard">M L Eberhard</name><name sortKey="Katz, S P" sort="Katz, S P" uniqKey="Katz S" first="S P" last="Katz">S P Katz</name><name sortKey="Lammie, P J" sort="Lammie, P J" uniqKey="Lammie P" first="P J" last="Lammie">P J Lammie</name><name sortKey="Leiva, L E" sort="Leiva, L E" uniqKey="Leiva L" first="L E" last="Leiva">L E Leiva</name><name sortKey="Lowrie, R C" sort="Lowrie, R C" uniqKey="Lowrie R" first="R C" last="Lowrie">R C Lowrie</name><name sortKey="Ruff, A J" sort="Ruff, A J" uniqKey="Ruff A" first="A J" last="Ruff">A J Ruff</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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