The significance of sentinel lymph node micrometastasis in breast cancer: Comparing outcomes with and without axillary clearance.
Identifieur interne : 008840 ( Ncbi/Merge ); précédent : 008839; suivant : 008841The significance of sentinel lymph node micrometastasis in breast cancer: Comparing outcomes with and without axillary clearance.
Auteurs : Mina M G. Youssef [Royaume-Uni] ; Diane Cameron [Royaume-Uni] ; Philip H. Pucher [Royaume-Uni] ; Sisse Olsen [Royaume-Uni] ; Douglas Ferguson [Royaume-Uni]Source :
- Breast (Edinburgh, Scotland) [ 1532-3080 ] ; 2016.
Descripteurs français
- KwdFr :
- Aisselle, Carcinome canalaire du sein (), Carcinome canalaire du sein (anatomopathologie), Carcinome lobulaire (), Carcinome lobulaire (anatomopathologie), Complications postopératoires (épidémiologie), Estimation de Kaplan-Meier, Femelle, Humains, Lymphadénectomie (), Lymphoedème (épidémiologie), Mastectomie, Micrométastase tumorale (anatomopathologie), Métastase lymphatique, Noeud lymphatique sentinelle (anatomopathologie), Noeuds lymphatiques (anatomopathologie), Pronostic, Radiothérapie adjuvante, Récidive tumorale locale (épidémiologie), Survie sans rechute, Traitement médicamenteux adjuvant, Tumeurs du sein (), Tumeurs du sein (anatomopathologie), Études cas-témoins, Études rétrospectives.
- MESH :
- anatomopathologie : Carcinome canalaire du sein, Carcinome lobulaire, Micrométastase tumorale, Noeud lymphatique sentinelle, Noeuds lymphatiques, Tumeurs du sein.
- épidémiologie : Complications postopératoires, Lymphoedème, Récidive tumorale locale.
- Aisselle, Carcinome canalaire du sein, Carcinome lobulaire, Estimation de Kaplan-Meier, Femelle, Humains, Lymphadénectomie, Mastectomie, Métastase lymphatique, Pronostic, Radiothérapie adjuvante, Survie sans rechute, Traitement médicamenteux adjuvant, Tumeurs du sein, Études cas-témoins, Études rétrospectives.
English descriptors
- KwdEn :
- Axilla, Breast Neoplasms (pathology), Breast Neoplasms (therapy), Carcinoma, Ductal, Breast (pathology), Carcinoma, Ductal, Breast (therapy), Carcinoma, Lobular (pathology), Carcinoma, Lobular (therapy), Case-Control Studies, Chemotherapy, Adjuvant, Disease-Free Survival, Female, Humans, Kaplan-Meier Estimate, Lymph Node Excision (methods), Lymph Nodes (pathology), Lymphatic Metastasis, Lymphedema (epidemiology), Mastectomy, Neoplasm Micrometastasis (pathology), Neoplasm Recurrence, Local (epidemiology), Postoperative Complications (epidemiology), Prognosis, Radiotherapy, Adjuvant, Retrospective Studies, Sentinel Lymph Node (pathology).
- MESH :
- epidemiology : Lymphedema, Neoplasm Recurrence, Local, Postoperative Complications.
- methods : Lymph Node Excision.
- pathology : Breast Neoplasms, Carcinoma, Ductal, Breast, Carcinoma, Lobular, Lymph Nodes, Neoplasm Micrometastasis, Sentinel Lymph Node.
- therapy : Breast Neoplasms, Carcinoma, Ductal, Breast, Carcinoma, Lobular.
- Axilla, Case-Control Studies, Chemotherapy, Adjuvant, Disease-Free Survival, Female, Humans, Kaplan-Meier Estimate, Lymphatic Metastasis, Mastectomy, Prognosis, Radiotherapy, Adjuvant, Retrospective Studies.
Abstract
Management of micrometastasis in the sentinel node is a controversial topic. Most of the guidelines don't recommend further axillary treatment if micrometastasis are the only finding in the sentinel node. However, some evidence suggests that micrometastasis have significant effect on long term outcomes and therefore indicate systemic treatment.
DOI: 10.1016/j.breast.2016.09.005
PubMed: 27668857
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Youssef</name><affiliation wicri:level="1"><nlm:affiliation>Department of Breast Surgery, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK. Electronic address: Mina.youssef@nhs.net.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Breast Surgery, Royal Devon and Exeter NHS Foundation Trust, Exeter</wicri:regionArea><wicri:noRegion>Exeter</wicri:noRegion></affiliation></author><author><name sortKey="Cameron, Diane" sort="Cameron, Diane" uniqKey="Cameron D" first="Diane" last="Cameron">Diane Cameron</name><affiliation wicri:level="1"><nlm:affiliation>Department of Breast Surgery, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Breast Surgery, Royal Devon and Exeter NHS Foundation Trust, Exeter</wicri:regionArea><wicri:noRegion>Exeter</wicri:noRegion></affiliation></author><author><name sortKey="Pucher, Philip H" sort="Pucher, Philip H" uniqKey="Pucher P" first="Philip H" last="Pucher">Philip H. 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uniqKey="Ferguson D" first="Douglas" last="Ferguson">Douglas Ferguson</name><affiliation wicri:level="1"><nlm:affiliation>Department of Breast Surgery, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Breast Surgery, Royal Devon and Exeter NHS Foundation Trust, Exeter</wicri:regionArea><wicri:noRegion>Exeter</wicri:noRegion></affiliation></author></analytic><series><title level="j">Breast (Edinburgh, Scotland)</title><idno type="eISSN">1532-3080</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Axilla</term><term>Breast Neoplasms (pathology)</term><term>Breast Neoplasms (therapy)</term><term>Carcinoma, Ductal, Breast (pathology)</term><term>Carcinoma, Ductal, Breast (therapy)</term><term>Carcinoma, Lobular (pathology)</term><term>Carcinoma, Lobular (therapy)</term><term>Case-Control Studies</term><term>Chemotherapy, Adjuvant</term><term>Disease-Free Survival</term><term>Female</term><term>Humans</term><term>Kaplan-Meier Estimate</term><term>Lymph Node Excision (methods)</term><term>Lymph Nodes (pathology)</term><term>Lymphatic Metastasis</term><term>Lymphedema (epidemiology)</term><term>Mastectomy</term><term>Neoplasm Micrometastasis (pathology)</term><term>Neoplasm Recurrence, Local (epidemiology)</term><term>Postoperative Complications (epidemiology)</term><term>Prognosis</term><term>Radiotherapy, Adjuvant</term><term>Retrospective Studies</term><term>Sentinel Lymph Node (pathology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Aisselle</term><term>Carcinome canalaire du sein ()</term><term>Carcinome canalaire du sein (anatomopathologie)</term><term>Carcinome lobulaire ()</term><term>Carcinome lobulaire (anatomopathologie)</term><term>Complications postopératoires (épidémiologie)</term><term>Estimation de Kaplan-Meier</term><term>Femelle</term><term>Humains</term><term>Lymphadénectomie ()</term><term>Lymphoedème (épidémiologie)</term><term>Mastectomie</term><term>Micrométastase tumorale (anatomopathologie)</term><term>Métastase lymphatique</term><term>Noeud lymphatique sentinelle (anatomopathologie)</term><term>Noeuds lymphatiques (anatomopathologie)</term><term>Pronostic</term><term>Radiothérapie adjuvante</term><term>Récidive tumorale locale (épidémiologie)</term><term>Survie sans rechute</term><term>Traitement médicamenteux adjuvant</term><term>Tumeurs du sein ()</term><term>Tumeurs du sein (anatomopathologie)</term><term>Études cas-témoins</term><term>Études rétrospectives</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Carcinome canalaire du sein</term><term>Carcinome lobulaire</term><term>Micrométastase tumorale</term><term>Noeud lymphatique sentinelle</term><term>Noeuds lymphatiques</term><term>Tumeurs du sein</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Lymphedema</term><term>Neoplasm Recurrence, Local</term><term>Postoperative Complications</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Lymph Node Excision</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Breast Neoplasms</term><term>Carcinoma, Ductal, Breast</term><term>Carcinoma, Lobular</term><term>Lymph Nodes</term><term>Neoplasm Micrometastasis</term><term>Sentinel Lymph Node</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Breast Neoplasms</term><term>Carcinoma, Ductal, Breast</term><term>Carcinoma, Lobular</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Complications postopératoires</term><term>Lymphoedème</term><term>Récidive tumorale locale</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Axilla</term><term>Case-Control Studies</term><term>Chemotherapy, Adjuvant</term><term>Disease-Free Survival</term><term>Female</term><term>Humans</term><term>Kaplan-Meier Estimate</term><term>Lymphatic Metastasis</term><term>Mastectomy</term><term>Prognosis</term><term>Radiotherapy, Adjuvant</term><term>Retrospective Studies</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Aisselle</term><term>Carcinome canalaire du sein</term><term>Carcinome lobulaire</term><term>Estimation de Kaplan-Meier</term><term>Femelle</term><term>Humains</term><term>Lymphadénectomie</term><term>Mastectomie</term><term>Métastase lymphatique</term><term>Pronostic</term><term>Radiothérapie adjuvante</term><term>Survie sans rechute</term><term>Traitement médicamenteux adjuvant</term><term>Tumeurs du sein</term><term>Études cas-témoins</term><term>Études rétrospectives</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Management of micrometastasis in the sentinel node is a controversial topic. Most of the guidelines don't recommend further axillary treatment if micrometastasis are the only finding in the sentinel node. However, some evidence suggests that micrometastasis have significant effect on long term outcomes and therefore indicate systemic treatment.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27668857</PMID><DateCreated><Year>2016</Year><Month>09</Month><Day>26</Day></DateCreated><DateCompleted><Year>2017</Year><Month>03</Month><Day>13</Day></DateCompleted><DateRevised><Year>2017</Year><Month>03</Month><Day>13</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1532-3080</ISSN><JournalIssue CitedMedium="Internet"><Volume>30</Volume><PubDate><Year>2016</Year><Month>Dec</Month></PubDate></JournalIssue><Title>Breast (Edinburgh, Scotland)</Title><ISOAbbreviation>Breast</ISOAbbreviation></Journal><ArticleTitle>The significance of sentinel lymph node micrometastasis in breast cancer: Comparing outcomes with and without axillary clearance.</ArticleTitle><Pagination><MedlinePgn>101-104</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0960-9776(16)30166-7</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.breast.2016.09.005</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Management of micrometastasis in the sentinel node is a controversial topic. Most of the guidelines don't recommend further axillary treatment if micrometastasis are the only finding in the sentinel node. However, some evidence suggests that micrometastasis have significant effect on long term outcomes and therefore indicate systemic treatment.</AbstractText><AbstractText Label="METHOD" NlmCategory="METHODS">Retrospective cohort study reviewing the management of patients with micrometastasis in the sentinel nodes. Two groups were compared, those who had further axillary clearance and those who had not. The primary endpoints were loco-regional recurrence and lymphedema rate. The secondary endpoints were distant metastasis rate, OS and DFS.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">95 patients were found to have micrometastasis or ITC in the axillary SNB over a period of 10 years. Of those, 38 patients had axillary clearance after SNB, while 57 did not. Lymphedema rate was 18.4% in the axillary clearance group versus 0% in the no axillary clearance group (p < 0.001). The LRR event was rare therefore not compared. Distant metastasis rate was 7.01% in the SNB group versus 2.6% in the axillary clearance group. There were no mortalities in the axillary clearance group. This compares to 7.01% among the patients who didn't have axillary clearance. All the patients who died had developed distant metastasis as a cause of death. There was a difference in OS between the two groups in favor of the axillary clearance group (p = 0.004).</AbstractText><AbstractText Label="DISCUSSION" NlmCategory="CONCLUSIONS">Although not an indication for axillary clearance recent guidelines, micrometastasis and ITC found in the SNB are a sign of a biologically different disease. This important information should be taken in consideration when planning the adjuvant treatment in those patients among other factors considered.</AbstractText><CopyrightInformation>Copyright © 2016 Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Youssef</LastName><ForeName>Mina M G</ForeName><Initials>MM</Initials><AffiliationInfo><Affiliation>Department of Breast Surgery, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK. Electronic address: Mina.youssef@nhs.net.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cameron</LastName><ForeName>Diane</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Breast Surgery, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pucher</LastName><ForeName>Philip H</ForeName><Initials>PH</Initials><AffiliationInfo><Affiliation>Division of Surgery, Imperial College, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Olsen</LastName><ForeName>Sisse</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Breast Surgery, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ferguson</LastName><ForeName>Douglas</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Breast Surgery, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>09</Month><Day>24</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Breast</MedlineTA><NlmUniqueID>9213011</NlmUniqueID><ISSNLinking>0960-9776</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D001365" MajorTopicYN="N">Axilla</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001943" MajorTopicYN="N">Breast Neoplasms</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName><QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018270" MajorTopicYN="N">Carcinoma, Ductal, Breast</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName><QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018275" MajorTopicYN="N">Carcinoma, Lobular</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName><QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016022" MajorTopicYN="N">Case-Control Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017024" MajorTopicYN="N">Chemotherapy, Adjuvant</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018572" MajorTopicYN="N">Disease-Free Survival</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053208" MajorTopicYN="N">Kaplan-Meier Estimate</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008197" MajorTopicYN="N">Lymph Node Excision</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008198" MajorTopicYN="N">Lymph Nodes</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008207" MajorTopicYN="N">Lymphatic Metastasis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008209" MajorTopicYN="N">Lymphedema</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008408" MajorTopicYN="N">Mastectomy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D061206" MajorTopicYN="N">Neoplasm Micrometastasis</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009364" MajorTopicYN="N">Neoplasm Recurrence, Local</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011183" MajorTopicYN="N">Postoperative Complications</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011379" MajorTopicYN="N">Prognosis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018714" MajorTopicYN="N">Radiotherapy, Adjuvant</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000071036" MajorTopicYN="N">Sentinel Lymph Node</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Axillary clearance</Keyword><Keyword MajorTopicYN="Y">Micrometastasis</Keyword><Keyword MajorTopicYN="Y">Sentinel Node Biopsy</Keyword><Keyword MajorTopicYN="Y">Survival</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>07</Month><Day>04</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2016</Year><Month>08</Month><Day>04</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>09</Month><Day>08</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>9</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>3</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>9</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27668857</ArticleId><ArticleId IdType="pii">S0960-9776(16)30166-7</ArticleId><ArticleId IdType="doi">10.1016/j.breast.2016.09.005</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li></region><settlement><li>Londres</li></settlement></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Youssef, Mina M G" sort="Youssef, Mina M G" uniqKey="Youssef M" first="Mina M G" last="Youssef">Mina M G. Youssef</name></noRegion><name sortKey="Cameron, Diane" sort="Cameron, Diane" uniqKey="Cameron D" first="Diane" last="Cameron">Diane Cameron</name><name sortKey="Ferguson, Douglas" sort="Ferguson, Douglas" uniqKey="Ferguson D" first="Douglas" last="Ferguson">Douglas Ferguson</name><name sortKey="Olsen, Sisse" sort="Olsen, Sisse" uniqKey="Olsen S" first="Sisse" last="Olsen">Sisse Olsen</name><name sortKey="Pucher, Philip H" sort="Pucher, Philip H" uniqKey="Pucher P" first="Philip H" last="Pucher">Philip H. Pucher</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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