Hyperkeratosis in human lower limb lymphedema: the effect of stagnant tissue fluid/lymph.
Identifieur interne : 007E75 ( Ncbi/Merge ); précédent : 007E74; suivant : 007E76Hyperkeratosis in human lower limb lymphedema: the effect of stagnant tissue fluid/lymph.
Auteurs : A. Domaszewska-Szostek [Pologne] ; M. Zaleska [Pologne] ; W L Olszewski [Pologne]Source :
- Journal of the European Academy of Dermatology and Venereology : JEADV [ 1468-3083 ] ; 2016.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- complications : Keratosis, Lymphedema.
- Body Fluids, Humans, Leg.
Abstract
Hyperkeratosis of skin in lower limb lymphedema is one of the sequelae of tissue fluid/lymph (TF/L) stasis, but its mechanisms remain unknown. It is noteworthy, nonetheless, that human TF/L contains high levels of growth factors and cytokines, and may serve as the physiological environment for keratinocyte (KC) proliferation.
DOI: 10.1111/jdv.13565
PubMed: 26869365
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pubmed:26869365Le document en format XML
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<author><name sortKey="Domaszewska Szostek, A" sort="Domaszewska Szostek, A" uniqKey="Domaszewska Szostek A" first="A" last="Domaszewska-Szostek">A. Domaszewska-Szostek</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Transplantation Surgery and Department of Human Epigenetics, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland.</nlm:affiliation>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Transplantation Surgery and Department of Human Epigenetics, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw</wicri:regionArea>
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<author><name sortKey="Zaleska, M" sort="Zaleska, M" uniqKey="Zaleska M" first="M" last="Zaleska">M. Zaleska</name>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Body Fluids</term>
<term>Humans</term>
<term>Keratosis (complications)</term>
<term>Leg</term>
<term>Lymphedema (complications)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Humains</term>
<term>Jambe</term>
<term>Kératose ()</term>
<term>Liquides biologiques</term>
<term>Lymphoedème ()</term>
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<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Keratosis</term>
<term>Lymphedema</term>
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<front><div type="abstract" xml:lang="en">Hyperkeratosis of skin in lower limb lymphedema is one of the sequelae of tissue fluid/lymph (TF/L) stasis, but its mechanisms remain unknown. It is noteworthy, nonetheless, that human TF/L contains high levels of growth factors and cytokines, and may serve as the physiological environment for keratinocyte (KC) proliferation.</div>
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<DateCreated><Year>2016</Year>
<Month>05</Month>
<Day>21</Day>
</DateCreated>
<DateCompleted><Year>2017</Year>
<Month>04</Month>
<Day>26</Day>
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<Month>Jun</Month>
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<Title>Journal of the European Academy of Dermatology and Venereology : JEADV</Title>
<ISOAbbreviation>J Eur Acad Dermatol Venereol</ISOAbbreviation>
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<ArticleTitle>Hyperkeratosis in human lower limb lymphedema: the effect of stagnant tissue fluid/lymph.</ArticleTitle>
<Pagination><MedlinePgn>1002-8</MedlinePgn>
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<ELocationID EIdType="doi" ValidYN="Y">10.1111/jdv.13565</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Hyperkeratosis of skin in lower limb lymphedema is one of the sequelae of tissue fluid/lymph (TF/L) stasis, but its mechanisms remain unknown. It is noteworthy, nonetheless, that human TF/L contains high levels of growth factors and cytokines, and may serve as the physiological environment for keratinocyte (KC) proliferation.</AbstractText>
<AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">The aim of the study was to investigate the effect of human TF/L on human KC proliferation, differentiation and on the expression of epidermal stem cell markers on them.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">KC were isolated from lymphedema and normal skin, and cultured for 1-14 days in TF/L with neutralized Interleukin 1β, Interleukin 6, tumour necrosis factor α (TNF-α), keratinocyte growth factor (KGF) or tumour growth factor β (TGF-β). Alternatively, KC receptors for these factors were blocked.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">The number of KC cultured in TF/L was increased, as was the percentage of mitotic figures. There was a higher percentage of p63, CD29, Ki67, PCNA, CK6, CK17, CK16 and a lower of CK10, CK14, filaggrin and involucrin-positive KC. Neutralization of TF/L IL-1β, IL-6, TNF-α and KGF as well as blockage of their receptors resulted in decreased percentage of mitotic KC. TGF-β had a limited effect on KC proliferation.</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Hyperkeratosis in lymphedema may be the effect of a high concentration of cytokines in the stagnant TF/L tissue, but not because of presumed changes in the KC.</AbstractText>
<CopyrightInformation>© 2016 European Academy of Dermatology and Venereology.</CopyrightInformation>
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<AffiliationInfo><Affiliation>Department of Transplantation and Vascular Surgery, Central Clinical Hospital, Ministry of Internal Affairs, Warsaw, Poland.</Affiliation>
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