Hyperkeratosis in human lower limb lymphedema: the effect of stagnant tissue fluid/lymph.
Identifieur interne : 000A04 ( PubMed/Corpus ); précédent : 000A03; suivant : 000A05Hyperkeratosis in human lower limb lymphedema: the effect of stagnant tissue fluid/lymph.
Auteurs : A. Domaszewska-Szostek ; M. Zaleska ; W L OlszewskiSource :
- Journal of the European Academy of Dermatology and Venereology : JEADV [ 1468-3083 ] ; 2016.
English descriptors
- KwdEn :
- MESH :
- complications : Keratosis, Lymphedema.
- Body Fluids, Humans, Leg.
Abstract
Hyperkeratosis of skin in lower limb lymphedema is one of the sequelae of tissue fluid/lymph (TF/L) stasis, but its mechanisms remain unknown. It is noteworthy, nonetheless, that human TF/L contains high levels of growth factors and cytokines, and may serve as the physiological environment for keratinocyte (KC) proliferation.
DOI: 10.1111/jdv.13565
PubMed: 26869365
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Hyperkeratosis in human lower limb lymphedema: the effect of stagnant tissue fluid/lymph.</title><author><name sortKey="Domaszewska Szostek, A" sort="Domaszewska Szostek, A" uniqKey="Domaszewska Szostek A" first="A" last="Domaszewska-Szostek">A. Domaszewska-Szostek</name><affiliation><nlm:affiliation>Department of Transplantation Surgery and Department of Human Epigenetics, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland.</nlm:affiliation></affiliation></author><author><name sortKey="Zaleska, M" sort="Zaleska, M" uniqKey="Zaleska M" first="M" last="Zaleska">M. Zaleska</name><affiliation><nlm:affiliation>Department of Transplantation Surgery and Department of Human Epigenetics, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland.</nlm:affiliation></affiliation></author><author><name sortKey="Olszewski, W L" sort="Olszewski, W L" uniqKey="Olszewski W" first="W L" last="Olszewski">W L Olszewski</name><affiliation><nlm:affiliation>Department of Transplantation Surgery and Department of Human Epigenetics, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:26869365</idno><idno type="pmid">26869365</idno><idno type="doi">10.1111/jdv.13565</idno><idno type="wicri:Area/PubMed/Corpus">000A04</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000A04</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Hyperkeratosis in human lower limb lymphedema: the effect of stagnant tissue fluid/lymph.</title><author><name sortKey="Domaszewska Szostek, A" sort="Domaszewska Szostek, A" uniqKey="Domaszewska Szostek A" first="A" last="Domaszewska-Szostek">A. Domaszewska-Szostek</name><affiliation><nlm:affiliation>Department of Transplantation Surgery and Department of Human Epigenetics, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland.</nlm:affiliation></affiliation></author><author><name sortKey="Zaleska, M" sort="Zaleska, M" uniqKey="Zaleska M" first="M" last="Zaleska">M. Zaleska</name><affiliation><nlm:affiliation>Department of Transplantation Surgery and Department of Human Epigenetics, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland.</nlm:affiliation></affiliation></author><author><name sortKey="Olszewski, W L" sort="Olszewski, W L" uniqKey="Olszewski W" first="W L" last="Olszewski">W L Olszewski</name><affiliation><nlm:affiliation>Department of Transplantation Surgery and Department of Human Epigenetics, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Journal of the European Academy of Dermatology and Venereology : JEADV</title><idno type="eISSN">1468-3083</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Body Fluids</term><term>Humans</term><term>Keratosis (complications)</term><term>Leg</term><term>Lymphedema (complications)</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Keratosis</term><term>Lymphedema</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Body Fluids</term><term>Humans</term><term>Leg</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Hyperkeratosis of skin in lower limb lymphedema is one of the sequelae of tissue fluid/lymph (TF/L) stasis, but its mechanisms remain unknown. It is noteworthy, nonetheless, that human TF/L contains high levels of growth factors and cytokines, and may serve as the physiological environment for keratinocyte (KC) proliferation.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26869365</PMID><DateCreated><Year>2016</Year><Month>05</Month><Day>21</Day></DateCreated><DateCompleted><Year>2017</Year><Month>04</Month><Day>26</Day></DateCompleted><DateRevised><Year>2017</Year><Month>04</Month><Day>26</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1468-3083</ISSN><JournalIssue CitedMedium="Internet"><Volume>30</Volume><Issue>6</Issue><PubDate><Year>2016</Year><Month>Jun</Month></PubDate></JournalIssue><Title>Journal of the European Academy of Dermatology and Venereology : JEADV</Title><ISOAbbreviation>J Eur Acad Dermatol Venereol</ISOAbbreviation></Journal><ArticleTitle>Hyperkeratosis in human lower limb lymphedema: the effect of stagnant tissue fluid/lymph.</ArticleTitle><Pagination><MedlinePgn>1002-8</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/jdv.13565</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Hyperkeratosis of skin in lower limb lymphedema is one of the sequelae of tissue fluid/lymph (TF/L) stasis, but its mechanisms remain unknown. It is noteworthy, nonetheless, that human TF/L contains high levels of growth factors and cytokines, and may serve as the physiological environment for keratinocyte (KC) proliferation.</AbstractText><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">The aim of the study was to investigate the effect of human TF/L on human KC proliferation, differentiation and on the expression of epidermal stem cell markers on them.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">KC were isolated from lymphedema and normal skin, and cultured for 1-14 days in TF/L with neutralized Interleukin 1β, Interleukin 6, tumour necrosis factor α (TNF-α), keratinocyte growth factor (KGF) or tumour growth factor β (TGF-β). Alternatively, KC receptors for these factors were blocked.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The number of KC cultured in TF/L was increased, as was the percentage of mitotic figures. There was a higher percentage of p63, CD29, Ki67, PCNA, CK6, CK17, CK16 and a lower of CK10, CK14, filaggrin and involucrin-positive KC. Neutralization of TF/L IL-1β, IL-6, TNF-α and KGF as well as blockage of their receptors resulted in decreased percentage of mitotic KC. TGF-β had a limited effect on KC proliferation.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Hyperkeratosis in lymphedema may be the effect of a high concentration of cytokines in the stagnant TF/L tissue, but not because of presumed changes in the KC.</AbstractText><CopyrightInformation>© 2016 European Academy of Dermatology and Venereology.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Domaszewska-Szostek</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Transplantation Surgery and Department of Human Epigenetics, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zaleska</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Transplantation Surgery and Department of Human Epigenetics, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Olszewski</LastName><ForeName>W L</ForeName><Initials>WL</Initials><AffiliationInfo><Affiliation>Department of Transplantation Surgery and Department of Human Epigenetics, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Transplantation and Vascular Surgery, Central Clinical Hospital, Ministry of Internal Affairs, Warsaw, Poland.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>02</Month><Day>11</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>J Eur Acad Dermatol Venereol</MedlineTA><NlmUniqueID>9216037</NlmUniqueID><ISSNLinking>0926-9959</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D001826" MajorTopicYN="Y">Body Fluids</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007642" MajorTopicYN="N">Keratosis</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007866" MajorTopicYN="Y">Leg</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008209" MajorTopicYN="N">Lymphedema</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>08</Month><Day>13</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>11</Month><Day>05</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>2</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>2</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>4</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26869365</ArticleId><ArticleId IdType="doi">10.1111/jdv.13565</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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