Revisiting the concept of CNS immune privilege
Identifieur interne : 007983 ( Ncbi/Merge ); précédent : 007982; suivant : 007984Revisiting the concept of CNS immune privilege
Auteurs : Antoine Louveau ; Tajie H. Harris ; Jonathan KipnisSource :
- Trends in immunology [ 1471-4906 ] ; 2015.
Abstract
Whereas the study of the interactions between the immune system and the central nervous system (CNS) has often focused on pathological conditions, the importance of neuroimmune communication in CNS homeostasis and function has become clear over that last two decades. Here we discuss the progression of our understanding of the interaction between the peripheral immune system and the CNS. We examine the notion of immune privilege of the CNS in light of both earlier findings and recent studies revealing a functional meningeal lymphatic system that drains cerebrospinal fluid (CSF) to the deep cervical lymph nodes, and consider the implications of a revised perspective on the immune privilege of the CNS on the etiology and pathology of different neurological disorders.
Url:
DOI: 10.1016/j.it.2015.08.006
PubMed: 26431936
PubMed Central: 4593064
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PMC:4593064Le document en format XML
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<front><div type="abstract" xml:lang="en"><p id="P1">Whereas the study of the interactions between the immune system and the central nervous system (CNS) has often focused on pathological conditions, the importance of neuroimmune communication in CNS homeostasis and function has become clear over that last two decades. Here we discuss the progression of our understanding of the interaction between the peripheral immune system and the CNS. We examine the notion of immune privilege of the CNS in light of both earlier findings and recent studies revealing a functional meningeal lymphatic system that drains cerebrospinal fluid (CSF) to the deep cervical lymph nodes, and consider the implications of a revised perspective on the immune privilege of the CNS on the etiology and pathology of different neurological disorders.</p>
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<contrib-group><contrib contrib-type="author"><name><surname>Louveau</surname>
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<contrib contrib-type="author"><name><surname>Harris</surname>
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<contrib contrib-type="author"><name><surname>Kipnis</surname>
<given-names>Jonathan</given-names>
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<aff id="A1">Center for Brain Immunology and Glia, Department of Neuroscience, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA</aff>
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<author-notes><corresp id="FN1"><label>*</label>
Correspondence to: J.K. (<email>kipnis@virginia.edu</email>
) Tel: 001 434-982-3858, Fax: 001 434-982-4380</corresp>
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<pub-date pub-type="nihms-submitted"><day>25</day>
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<volume>36</volume>
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<pmc-comment>elocation-id from pubmed: 10.1016/j.it.2015.08.006</pmc-comment>
<abstract><p id="P1">Whereas the study of the interactions between the immune system and the central nervous system (CNS) has often focused on pathological conditions, the importance of neuroimmune communication in CNS homeostasis and function has become clear over that last two decades. Here we discuss the progression of our understanding of the interaction between the peripheral immune system and the CNS. We examine the notion of immune privilege of the CNS in light of both earlier findings and recent studies revealing a functional meningeal lymphatic system that drains cerebrospinal fluid (CSF) to the deep cervical lymph nodes, and consider the implications of a revised perspective on the immune privilege of the CNS on the etiology and pathology of different neurological disorders.</p>
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<name sortKey="Louveau, Antoine" sort="Louveau, Antoine" uniqKey="Louveau A" first="Antoine" last="Louveau">Antoine Louveau</name>
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