LymphedemaV1, Pmc, Checkpoint, bibRecord, 000E96

Revisiting the concept of CNS immune privilege

Identifieur interne : 000E96 ( Pmc/Checkpoint ); précédent : 000E95; suivant : 000E97

Revisiting the concept of CNS immune privilege

Auteurs : Antoine Louveau ; Tajie H. Harris ; Jonathan Kipnis

Source :

Trends in immunology [ 1471-4906 ] ; 2015.

RBID : PMC:4593064

Abstract

Whereas the study of the interactions between the immune system and the central nervous system (CNS) has often focused on pathological conditions, the importance of neuroimmune communication in CNS homeostasis and function has become clear over that last two decades. Here we discuss the progression of our understanding of the interaction between the peripheral immune system and the CNS. We examine the notion of immune privilege of the CNS in light of both earlier findings and recent studies revealing a functional meningeal lymphatic system that drains cerebrospinal fluid (CSF) to the deep cervical lymph nodes, and consider the implications of a revised perspective on the immune privilege of the CNS on the etiology and pathology of different neurological disorders.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4593064

DOI: 10.1016/j.it.2015.08.006
PubMed: 26431936
PubMed Central: 4593064

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Pmc, to step Corpus: 003451
to stream Pmc, to step Curation: 003450

Links to Exploration step

PMC:4593064

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Revisiting the concept of CNS immune privilege</title>
<author><name sortKey="Louveau, Antoine" sort="Louveau, Antoine" uniqKey="Louveau A" first="Antoine" last="Louveau">Antoine Louveau</name>
</author>
<author><name sortKey="Harris, Tajie H" sort="Harris, Tajie H" uniqKey="Harris T" first="Tajie H." last="Harris">Tajie H. Harris</name>
</author>
<author><name sortKey="Kipnis, Jonathan" sort="Kipnis, Jonathan" uniqKey="Kipnis J" first="Jonathan" last="Kipnis">Jonathan Kipnis</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">26431936</idno>
<idno type="pmc">4593064</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4593064</idno>
<idno type="RBID">PMC:4593064</idno>
<idno type="doi">10.1016/j.it.2015.08.006</idno>
<date when="2015">2015</date>
<idno type="wicri:Area/Pmc/Corpus">003451</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">003451</idno>
<idno type="wicri:Area/Pmc/Curation">003450</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">003450</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000E96</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000E96</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Revisiting the concept of CNS immune privilege</title>
<author><name sortKey="Louveau, Antoine" sort="Louveau, Antoine" uniqKey="Louveau A" first="Antoine" last="Louveau">Antoine Louveau</name>
</author>
<author><name sortKey="Harris, Tajie H" sort="Harris, Tajie H" uniqKey="Harris T" first="Tajie H." last="Harris">Tajie H. Harris</name>
</author>
<author><name sortKey="Kipnis, Jonathan" sort="Kipnis, Jonathan" uniqKey="Kipnis J" first="Jonathan" last="Kipnis">Jonathan Kipnis</name>
</author>
</analytic>
<series><title level="j">Trends in immunology</title>
<idno type="ISSN">1471-4906</idno>
<idno type="eISSN">1471-4981</idno>
<imprint><date when="2015">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P1">Whereas the study of the interactions between the immune system and the central nervous system (CNS) has often focused on pathological conditions, the importance of neuroimmune communication in CNS homeostasis and function has become clear over that last two decades. Here we discuss the progression of our understanding of the interaction between the peripheral immune system and the CNS. We examine the notion of immune privilege of the CNS in light of both earlier findings and recent studies revealing a functional meningeal lymphatic system that drains cerebrospinal fluid (CSF) to the deep cervical lymph nodes, and consider the implications of a revised perspective on the immune privilege of the CNS on the etiology and pathology of different neurological disorders.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
  <pmc-dir>properties manuscript</pmc-dir>
  <front><journal-meta><journal-id journal-id-type="nlm-journal-id">100966032</journal-id>
<journal-id journal-id-type="pubmed-jr-id">22039</journal-id>
<journal-id journal-id-type="nlm-ta">Trends Immunol</journal-id>
<journal-id journal-id-type="iso-abbrev">Trends Immunol.</journal-id>
<journal-title-group><journal-title>Trends in immunology</journal-title>
</journal-title-group>
<issn pub-type="ppub">1471-4906</issn>
<issn pub-type="epub">1471-4981</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">26431936</article-id>
<article-id pub-id-type="pmc">4593064</article-id>
<article-id pub-id-type="doi">10.1016/j.it.2015.08.006</article-id>
<article-id pub-id-type="manuscript">NIHMS717534</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Revisiting the concept of CNS immune privilege</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Louveau</surname>
<given-names>Antoine</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Harris</surname>
<given-names>Tajie H.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Kipnis</surname>
<given-names>Jonathan</given-names>
</name>
</contrib>
<aff id="A1">Center for Brain Immunology and Glia, Department of Neuroscience, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA</aff>
</contrib-group>
<author-notes><corresp id="FN1"><label>*</label>
Correspondence to: J.K. (<email>kipnis@virginia.edu</email>
) Tel: 001 434-982-3858, Fax: 001 434-982-4380</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>25</day>
<month>8</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="ppub"><month>10</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>01</day>
<month>10</month>
<year>2016</year>
</pub-date>
<volume>36</volume>
<issue>10</issue>
<fpage>569</fpage>
<lpage>577</lpage>
<pmc-comment>elocation-id from pubmed: 10.1016/j.it.2015.08.006</pmc-comment>
      <abstract><p id="P1">Whereas the study of the interactions between the immune system and the central nervous system (CNS) has often focused on pathological conditions, the importance of neuroimmune communication in CNS homeostasis and function has become clear over that last two decades. Here we discuss the progression of our understanding of the interaction between the peripheral immune system and the CNS. We examine the notion of immune privilege of the CNS in light of both earlier findings and recent studies revealing a functional meningeal lymphatic system that drains cerebrospinal fluid (CSF) to the deep cervical lymph nodes, and consider the implications of a revised perspective on the immune privilege of the CNS on the etiology and pathology of different neurological disorders.</p>
</abstract>
</article-meta>
</front>
</pmc>
<affiliations><list></list>
<tree><noCountry><name sortKey="Harris, Tajie H" sort="Harris, Tajie H" uniqKey="Harris T" first="Tajie H." last="Harris">Tajie H. Harris</name>
<name sortKey="Kipnis, Jonathan" sort="Kipnis, Jonathan" uniqKey="Kipnis J" first="Jonathan" last="Kipnis">Jonathan Kipnis</name>
<name sortKey="Louveau, Antoine" sort="Louveau, Antoine" uniqKey="Louveau A" first="Antoine" last="Louveau">Antoine Louveau</name>
</noCountry>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Pmc/Checkpoint

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000E96 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Pmc/Checkpoint/biblio.hfd -nk 000E96 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Sante
   |area=    LymphedemaV1
   |flux=    Pmc
   |étape=   Checkpoint
   |type=    RBID
   |clé=     PMC:4593064
   |texte=   Revisiting the concept of CNS immune privilege
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Checkpoint/RBID.i   -Sk "pubmed:26431936" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Checkpoint/biblio.hfd   \
       | NlmPubMed2Wicri -a LymphedemaV1

This area was generated with Dilib version V0.6.31.
Data generation: Sat Nov 4 17:40:35 2017. Site generation: Tue Feb 13 16:42:16 2024

	Serveur d'exploration sur le lymphœdème
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur le lymphœdème

Revisiting the concept of CNS immune privilege

Revisiting the concept of CNS immune privilege

Source :

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki