Long-term survival of a patient with scalp angiosarcoma and multiple metastases treated using combination therapy: A case report
Identifieur interne : 007163 ( Ncbi/Merge ); précédent : 007162; suivant : 007164Long-term survival of a patient with scalp angiosarcoma and multiple metastases treated using combination therapy: A case report
Auteurs : Jun Ye [République populaire de Chine] ; Xiao-Fen Li [République populaire de Chine] ; Yong-Dong Wang [République populaire de Chine] ; Ying Yuan [République populaire de Chine]Source :
- Oncology Letters [ 1792-1074 ] ; 2015.
Abstract
Angiosarcoma is a rare and deadly malignancy originating from the vascular endothelial cells. Surgery is the most effective method to cure this disease, but for metastatic angiosarcoma, a chemotherapy-based treatment is the main therapeutic choice. However, there is currently no standard chemotherapy regimen. The current study reports the case of a 66-year-old male with post-operative scalp angiosarcoma recurrence and multiple metastases. The patient obtained a complete response to first-line combination chemotherapy consisting of cyclophosphamide, epirubicin, vincristine and dacarbazine, with a progression-free survival time of eight months. After benefitting from subsequent comprehensive treatment including, cyclophosphamide, epirubicin, vincristine, dacarbazine, docetaxel, cisplatin, gemcitabine and radiotherapy and anti-angiogenic therapy, the patient obtained an overall survival time of 38 months following initial diagnosis.
Url:
DOI: 10.3892/ol.2015.2919
PubMed: 25789030
PubMed Central: 4356293
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PMC:4356293Le document en format XML
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<front><div type="abstract" xml:lang="en"><p>Angiosarcoma is a rare and deadly malignancy originating from the vascular endothelial cells. Surgery is the most effective method to cure this disease, but for metastatic angiosarcoma, a chemotherapy-based treatment is the main therapeutic choice. However, there is currently no standard chemotherapy regimen. The current study reports the case of a 66-year-old male with post-operative scalp angiosarcoma recurrence and multiple metastases. The patient obtained a complete response to first-line combination chemotherapy consisting of cyclophosphamide, epirubicin, vincristine and dacarbazine, with a progression-free survival time of eight months. After benefitting from subsequent comprehensive treatment including, cyclophosphamide, epirubicin, vincristine, dacarbazine, docetaxel, cisplatin, gemcitabine and radiotherapy and anti-angiogenic therapy, the patient obtained an overall survival time of 38 months following initial diagnosis.</p>
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<front><journal-meta><journal-id journal-id-type="nlm-ta">Oncol Lett</journal-id>
<journal-id journal-id-type="iso-abbrev">Oncol Lett</journal-id>
<journal-id journal-id-type="publisher-id">OL</journal-id>
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<issn pub-type="ppub">1792-1074</issn>
<issn pub-type="epub">1792-1082</issn>
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<title-group><article-title>Long-term survival of a patient with scalp angiosarcoma and multiple metastases treated using combination therapy: A case report</article-title>
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<contrib-group><contrib contrib-type="author"><name><surname>YE</surname>
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<xref ref-type="aff" rid="af2-ol-09-04-1725">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>WANG</surname>
<given-names>YONG-DONG</given-names>
</name>
<xref ref-type="aff" rid="af1-ol-09-04-1725">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>YUAN</surname>
<given-names>YING</given-names>
</name>
<xref ref-type="aff" rid="af2-ol-09-04-1725">2</xref>
<xref ref-type="aff" rid="af3-ol-09-04-1725">3</xref>
<xref ref-type="corresp" rid="c1-ol-09-04-1725"></xref>
</contrib>
</contrib-group>
<aff id="af1-ol-09-04-1725"><label>1</label>
Department of Dermatology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, P.R. China</aff>
<aff id="af2-ol-09-04-1725"><label>2</label>
Department of Medical Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, P.R. China</aff>
<aff id="af3-ol-09-04-1725"><label>3</label>
Key Laboratory of Cancer Prevention and Intervention of Ministry of Education, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, P.R. China</aff>
<author-notes><corresp id="c1-ol-09-04-1725">Correspondence to: Dr Ying Yuan, Department of Medical Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, 88 Jie-Fang Road, Hangzhou, Zhejiang 310009, P.R. China, E-mail: <email>yuanying1999@zju.edu.cn</email>
</corresp>
</author-notes>
<pub-date pub-type="ppub"><month>4</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="epub"><day>29</day>
<month>1</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>29</day>
<month>1</month>
<year>2015</year>
</pub-date>
<pmc-comment> PMC Release delay is 0 months and 0 days and was based on the
. </pmc-comment>
<volume>9</volume>
<issue>4</issue>
<fpage>1725</fpage>
<lpage>1728</lpage>
<history><date date-type="received"><day>09</day>
<month>5</month>
<year>2014</year>
</date>
<date date-type="accepted"><day>13</day>
<month>1</month>
<year>2015</year>
</date>
</history>
<permissions><copyright-statement>Copyright © 2015, Spandidos Publications</copyright-statement>
<copyright-year>2015</copyright-year>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/3.0"><license-p>This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.</license-p>
</license>
</permissions>
<abstract><p>Angiosarcoma is a rare and deadly malignancy originating from the vascular endothelial cells. Surgery is the most effective method to cure this disease, but for metastatic angiosarcoma, a chemotherapy-based treatment is the main therapeutic choice. However, there is currently no standard chemotherapy regimen. The current study reports the case of a 66-year-old male with post-operative scalp angiosarcoma recurrence and multiple metastases. The patient obtained a complete response to first-line combination chemotherapy consisting of cyclophosphamide, epirubicin, vincristine and dacarbazine, with a progression-free survival time of eight months. After benefitting from subsequent comprehensive treatment including, cyclophosphamide, epirubicin, vincristine, dacarbazine, docetaxel, cisplatin, gemcitabine and radiotherapy and anti-angiogenic therapy, the patient obtained an overall survival time of 38 months following initial diagnosis.</p>
</abstract>
<kwd-group><kwd>angiosarcoma</kwd>
<kwd>scalp</kwd>
<kwd>comprehensive treatment</kwd>
</kwd-group>
</article-meta>
</front>
<floats-group><fig id="f1-ol-09-04-1725" orientation="portrait" position="float"><label>Figure 1</label>
<caption><p>Sections stained with hematoxylin and eosin showing angiosarcoma of the scalp (original magnification, ×40).</p>
</caption>
<graphic xlink:href="OL-09-04-1725-g00"></graphic>
</fig>
<fig id="f2-ol-09-04-1725" orientation="portrait" position="float"><label>Figure 2</label>
<caption><p>Recurrence of the scalp angiosarcoma.</p>
</caption>
<graphic xlink:href="OL-09-04-1725-g01"></graphic>
</fig>
</floats-group>
</pmc>
<affiliations><list><country><li>République populaire de Chine</li>
</country>
</list>
<tree><country name="République populaire de Chine"><noRegion><name sortKey="Ye, Jun" sort="Ye, Jun" uniqKey="Ye J" first="Jun" last="Ye">Jun Ye</name>
</noRegion>
<name sortKey="Li, Xiao Fen" sort="Li, Xiao Fen" uniqKey="Li X" first="Xiao-Fen" last="Li">Xiao-Fen Li</name>
<name sortKey="Wang, Yong Dong" sort="Wang, Yong Dong" uniqKey="Wang Y" first="Yong-Dong" last="Wang">Yong-Dong Wang</name>
<name sortKey="Yuan, Ying" sort="Yuan, Ying" uniqKey="Yuan Y" first="Ying" last="Yuan">Ying Yuan</name>
<name sortKey="Yuan, Ying" sort="Yuan, Ying" uniqKey="Yuan Y" first="Ying" last="Yuan">Ying Yuan</name>
</country>
</tree>
</affiliations>
</record>
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