Long-term survival of a patient with scalp angiosarcoma and multiple metastases treated using combination therapy: A case report
Identifieur interne : 001129 ( Pmc/Checkpoint ); précédent : 001128; suivant : 001130Long-term survival of a patient with scalp angiosarcoma and multiple metastases treated using combination therapy: A case report
Auteurs : Jun Ye [République populaire de Chine] ; Xiao-Fen Li [République populaire de Chine] ; Yong-Dong Wang [République populaire de Chine] ; Ying Yuan [République populaire de Chine]Source :
- Oncology Letters [ 1792-1074 ] ; 2015.
Abstract
Angiosarcoma is a rare and deadly malignancy originating from the vascular endothelial cells. Surgery is the most effective method to cure this disease, but for metastatic angiosarcoma, a chemotherapy-based treatment is the main therapeutic choice. However, there is currently no standard chemotherapy regimen. The current study reports the case of a 66-year-old male with post-operative scalp angiosarcoma recurrence and multiple metastases. The patient obtained a complete response to first-line combination chemotherapy consisting of cyclophosphamide, epirubicin, vincristine and dacarbazine, with a progression-free survival time of eight months. After benefitting from subsequent comprehensive treatment including, cyclophosphamide, epirubicin, vincristine, dacarbazine, docetaxel, cisplatin, gemcitabine and radiotherapy and anti-angiogenic therapy, the patient obtained an overall survival time of 38 months following initial diagnosis.
Url:
DOI: 10.3892/ol.2015.2919
PubMed: 25789030
PubMed Central: 4356293
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China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Dermatology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang</wicri:regionArea><wicri:noRegion>Zhejiang</wicri:noRegion></affiliation></author><author><name sortKey="Li, Xiao Fen" sort="Li, Xiao Fen" uniqKey="Li X" first="Xiao-Fen" last="Li">Xiao-Fen Li</name><affiliation wicri:level="1"><nlm:aff id="af2-ol-09-04-1725">Department of Medical Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Medical Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang</wicri:regionArea><wicri:noRegion>Zhejiang</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Yong Dong" sort="Wang, Yong Dong" uniqKey="Wang Y" first="Yong-Dong" last="Wang">Yong-Dong Wang</name><affiliation wicri:level="1"><nlm:aff id="af1-ol-09-04-1725">Department of Dermatology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Dermatology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang</wicri:regionArea><wicri:noRegion>Zhejiang</wicri:noRegion></affiliation></author><author><name sortKey="Yuan, Ying" sort="Yuan, Ying" uniqKey="Yuan Y" first="Ying" last="Yuan">Ying Yuan</name><affiliation wicri:level="1"><nlm:aff id="af2-ol-09-04-1725">Department of Medical Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Medical Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang</wicri:regionArea><wicri:noRegion>Zhejiang</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af3-ol-09-04-1725">Key Laboratory of Cancer Prevention and Intervention of Ministry of Education, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, P.R. 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China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Dermatology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang</wicri:regionArea><wicri:noRegion>Zhejiang</wicri:noRegion></affiliation></author><author><name sortKey="Li, Xiao Fen" sort="Li, Xiao Fen" uniqKey="Li X" first="Xiao-Fen" last="Li">Xiao-Fen Li</name><affiliation wicri:level="1"><nlm:aff id="af2-ol-09-04-1725">Department of Medical Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Medical Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang</wicri:regionArea><wicri:noRegion>Zhejiang</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Yong Dong" sort="Wang, Yong Dong" uniqKey="Wang Y" first="Yong-Dong" last="Wang">Yong-Dong Wang</name><affiliation wicri:level="1"><nlm:aff id="af1-ol-09-04-1725">Department of Dermatology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Dermatology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang</wicri:regionArea><wicri:noRegion>Zhejiang</wicri:noRegion></affiliation></author><author><name sortKey="Yuan, Ying" sort="Yuan, Ying" uniqKey="Yuan Y" first="Ying" last="Yuan">Ying Yuan</name><affiliation wicri:level="1"><nlm:aff id="af2-ol-09-04-1725">Department of Medical Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Medical Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang</wicri:regionArea><wicri:noRegion>Zhejiang</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af3-ol-09-04-1725">Key Laboratory of Cancer Prevention and Intervention of Ministry of Education, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Cancer Prevention and Intervention of Ministry of Education, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang</wicri:regionArea><wicri:noRegion>Zhejiang</wicri:noRegion></affiliation></author></analytic><series><title level="j">Oncology Letters</title><idno type="ISSN">1792-1074</idno><idno type="eISSN">1792-1082</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Angiosarcoma is a rare and deadly malignancy originating from the vascular endothelial cells. Surgery is the most effective method to cure this disease, but for metastatic angiosarcoma, a chemotherapy-based treatment is the main therapeutic choice. However, there is currently no standard chemotherapy regimen. The current study reports the case of a 66-year-old male with post-operative scalp angiosarcoma recurrence and multiple metastases. The patient obtained a complete response to first-line combination chemotherapy consisting of cyclophosphamide, epirubicin, vincristine and dacarbazine, with a progression-free survival time of eight months. After benefitting from subsequent comprehensive treatment including, cyclophosphamide, epirubicin, vincristine, dacarbazine, docetaxel, cisplatin, gemcitabine and radiotherapy and anti-angiogenic therapy, the patient obtained an overall survival time of 38 months following initial diagnosis.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Mark, Rj" uniqKey="Mark R">RJ Mark</name></author><author><name sortKey="Poen, Jc" uniqKey="Poen J">JC Poen</name></author><author><name sortKey="Tran, Lm" uniqKey="Tran L">LM Tran</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cafiero, F" uniqKey="Cafiero F">F Cafiero</name></author><author><name sortKey="Gipponi, M" uniqKey="Gipponi M">M Gipponi</name></author><author><name sortKey="Peressini, A" uniqKey="Peressini A">A Peressini</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Aust, Mr" uniqKey="Aust M">MR 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sortKey="Yuan, Zy" uniqKey="Yuan Z">ZY Yuan</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Oncol Lett</journal-id><journal-id journal-id-type="iso-abbrev">Oncol Lett</journal-id><journal-id journal-id-type="publisher-id">OL</journal-id><journal-title-group><journal-title>Oncology Letters</journal-title></journal-title-group><issn pub-type="ppub">1792-1074</issn><issn pub-type="epub">1792-1082</issn><publisher><publisher-name>D.A. Spandidos</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25789030</article-id><article-id pub-id-type="pmc">4356293</article-id><article-id pub-id-type="doi">10.3892/ol.2015.2919</article-id><article-id pub-id-type="publisher-id">ol-09-04-1725</article-id><article-categories><subj-group subj-group-type="heading"><subject>Articles</subject></subj-group></article-categories><title-group><article-title>Long-term survival of a patient with scalp angiosarcoma and multiple metastases treated using combination therapy: A case report</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>YE</surname><given-names>JUN</given-names></name><xref ref-type="aff" rid="af1-ol-09-04-1725">1</xref></contrib><contrib contrib-type="author"><name><surname>LI</surname><given-names>XIAO-FEN</given-names></name><xref ref-type="aff" rid="af2-ol-09-04-1725">2</xref></contrib><contrib contrib-type="author"><name><surname>WANG</surname><given-names>YONG-DONG</given-names></name><xref ref-type="aff" rid="af1-ol-09-04-1725">1</xref></contrib><contrib contrib-type="author"><name><surname>YUAN</surname><given-names>YING</given-names></name><xref ref-type="aff" rid="af2-ol-09-04-1725">2</xref><xref ref-type="aff" rid="af3-ol-09-04-1725">3</xref><xref ref-type="corresp" rid="c1-ol-09-04-1725"></xref></contrib></contrib-group><aff id="af1-ol-09-04-1725"><label>1</label>Department of Dermatology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, P.R. China</aff><aff id="af2-ol-09-04-1725"><label>2</label>Department of Medical Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, P.R. China</aff><aff id="af3-ol-09-04-1725"><label>3</label>Key Laboratory of Cancer Prevention and Intervention of Ministry of Education, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, P.R. China</aff><author-notes><corresp id="c1-ol-09-04-1725">Correspondence to: Dr Ying Yuan, Department of Medical Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, 88 Jie-Fang Road, Hangzhou, Zhejiang 310009, P.R. China, E-mail: <email>yuanying1999@zju.edu.cn</email></corresp></author-notes><pub-date pub-type="ppub"><month>4</month><year>2015</year></pub-date><pub-date pub-type="epub"><day>29</day><month>1</month><year>2015</year></pub-date><pub-date pub-type="pmc-release"><day>29</day><month>1</month><year>2015</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on the
<volume>9</volume><issue>4</issue><fpage>1725</fpage><lpage>1728</lpage><history><date date-type="received"><day>09</day><month>5</month><year>2014</year></date><date date-type="accepted"><day>13</day><month>1</month><year>2015</year></date></history><permissions><copyright-statement>Copyright © 2015, Spandidos Publications</copyright-statement><copyright-year>2015</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/3.0"><license-p>This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.</license-p></license></permissions><abstract><p>Angiosarcoma is a rare and deadly malignancy originating from the vascular endothelial cells. Surgery is the most effective method to cure this disease, but for metastatic angiosarcoma, a chemotherapy-based treatment is the main therapeutic choice. However, there is currently no standard chemotherapy regimen. The current study reports the case of a 66-year-old male with post-operative scalp angiosarcoma recurrence and multiple metastases. The patient obtained a complete response to first-line combination chemotherapy consisting of cyclophosphamide, epirubicin, vincristine and dacarbazine, with a progression-free survival time of eight months. After benefitting from subsequent comprehensive treatment including, cyclophosphamide, epirubicin, vincristine, dacarbazine, docetaxel, cisplatin, gemcitabine and radiotherapy and anti-angiogenic therapy, the patient obtained an overall survival time of 38 months following initial diagnosis.</p></abstract><kwd-group><kwd>angiosarcoma</kwd><kwd>scalp</kwd><kwd>comprehensive treatment</kwd></kwd-group></article-meta></front><floats-group><fig id="f1-ol-09-04-1725" orientation="portrait" position="float"><label>Figure 1</label><caption><p>Sections stained with hematoxylin and eosin showing angiosarcoma of the scalp (original magnification, ×40).</p></caption><graphic xlink:href="OL-09-04-1725-g00"></graphic></fig><fig id="f2-ol-09-04-1725" orientation="portrait" position="float"><label>Figure 2</label><caption><p>Recurrence of the scalp angiosarcoma.</p></caption><graphic xlink:href="OL-09-04-1725-g01"></graphic></fig></floats-group></pmc><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Ye, Jun" sort="Ye, Jun" uniqKey="Ye J" first="Jun" last="Ye">Jun Ye</name></noRegion><name sortKey="Li, Xiao Fen" sort="Li, Xiao Fen" uniqKey="Li X" first="Xiao-Fen" last="Li">Xiao-Fen Li</name><name sortKey="Wang, Yong Dong" sort="Wang, Yong Dong" uniqKey="Wang Y" first="Yong-Dong" last="Wang">Yong-Dong Wang</name><name sortKey="Yuan, Ying" sort="Yuan, Ying" uniqKey="Yuan Y" first="Ying" last="Yuan">Ying Yuan</name><name sortKey="Yuan, Ying" sort="Yuan, Ying" uniqKey="Yuan Y" first="Ying" last="Yuan">Ying Yuan</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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