Lymphangiogenesis and Lymphangiogenic Growth Factors.
Identifieur interne : 007014 ( Ncbi/Merge ); précédent : 007013; suivant : 007015Lymphangiogenesis and Lymphangiogenic Growth Factors.
Auteurs : Pauliina Hartiala [Finlande] ; Anne M. Saarikko [Finlande]Source :
- Journal of reconstructive microsurgery [ 1098-8947 ] ; 2016.
Descripteurs français
- KwdFr :
- Animaux, Facteurs de croissance endothéliale vasculaire (pharmacologie), Facteurs de transcription Forkhead (pharmacologie), Humains, Inflammation (anatomopathologie), Lymphangiogenèse (physiologie), Lymphoedème (), Lymphoedème (traitement médicamenteux), Microchirurgie, Métastase lymphatique (anatomopathologie), Noeuds lymphatiques (transplantation), Protéines et peptides de signalisation intercellulaire (pharmacologie), Système lymphatique (embryologie).
- MESH :
- anatomopathologie : Inflammation, Métastase lymphatique.
- embryologie : Système lymphatique.
- pharmacologie : Facteurs de croissance endothéliale vasculaire, Facteurs de transcription Forkhead, Protéines et peptides de signalisation intercellulaire.
- physiologie : Lymphangiogenèse.
- traitement médicamenteux : Lymphoedème.
- Animaux, Humains, Lymphoedème, Microchirurgie, Noeuds lymphatiques.
English descriptors
- KwdEn :
- Animals, Forkhead Transcription Factors (pharmacology), Humans, Inflammation (pathology), Intercellular Signaling Peptides and Proteins (pharmacology), Lymph Nodes (transplantation), Lymphangiogenesis (physiology), Lymphatic Metastasis (pathology), Lymphatic System (embryology), Lymphedema (drug therapy), Lymphedema (surgery), Microsurgery, Vascular Endothelial Growth Factors (pharmacology).
- MESH :
- chemical , pharmacology : Forkhead Transcription Factors, Intercellular Signaling Peptides and Proteins, Vascular Endothelial Growth Factors.
- drug therapy : Lymphedema.
- embryology : Lymphatic System.
- pathology : Inflammation, Lymphatic Metastasis.
- physiology : Lymphangiogenesis.
- surgery : Lymphedema.
- transplantation : Lymph Nodes.
- Animals, Humans, Microsurgery.
Abstract
Lymphedema is a progressive disease caused by damage to the lymphatic network. Recent development in the fields of preclinical growth factor research and lymphedema microsurgery promise new hope for lymphedema patients. In this article, we review the latest results on basic research and highlight the role of specific growth factors in normal lymphatic development and several disease states. Lymph node transfer, a new promising method in reconstructive lymphatic microsurgery, is also dependent on the lymphatic vascular regrowth and lymphangiogenic growth factors. We discuss the scientific basis of lymph node transfer and therapeutic potential of lymphangiogenic growth factors in the treatment of lymphedema.
DOI: 10.1055/s-0035-1544179
PubMed: 25665098
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