Bone morphogenetic protein 9 (BMP9) controls lymphatic vessel maturation and valve formation
Identifieur interne : 005995 ( Ncbi/Merge ); précédent : 005994; suivant : 005996Bone morphogenetic protein 9 (BMP9) controls lymphatic vessel maturation and valve formation
Auteurs : Sandrine Levet [France] ; Delphine Ciais [France] ; Galina Merdzhanova [France] ; Christine Mallet [France] ; Teresa A. Zimmers [États-Unis] ; Se-Jin Lee [États-Unis] ; Fabrice P. Navarro [France] ; Isabelle Texier [France] ; Jean-Jacques Feige [France] ; Sabine Bailly [France] ; Daniel Vittet [France]Source :
- Blood [ 0006-4971 ] ; 2013.
Abstract
BMP9 is required for lymphatic valve formation. Mice deficient in Bmp9 exhibit reduction in lymphatic draining efficiency.
Url:
DOI: 10.1182/blood-2012-12-472142
PubMed: 23741013
PubMed Central: 3724195
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Laboratoire d'Electronique de Technologie de l'Information, Campus d'innovation pour les micro et nanotechnologies Grenoble, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Commissariat à l'énergie atomique et aux énergies alternatives, Laboratoire d'Electronique de Technologie de l'Information, Campus d'innovation pour les micro et nanotechnologies Grenoble</wicri:regionArea><wicri:noRegion>Campus d'innovation pour les micro et nanotechnologies Grenoble</wicri:noRegion><wicri:noRegion>Campus d'innovation pour les micro et nanotechnologies Grenoble</wicri:noRegion></affiliation></author><author><name sortKey="Feige, Jean Jacques" sort="Feige, Jean Jacques" uniqKey="Feige J" first="Jean-Jacques" last="Feige">Jean-Jacques Feige</name><affiliation wicri:level="3"><nlm:aff id="aff1">INSERM U1036, Grenoble, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1036, Grenoble</wicri:regionArea><placeName><region 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l'énergie atomique et aux énergies alternatives, Direction des Sciences du Vivant, Institut de Recherches en Technologies et Sciences pour le Vivant, Laboratoire Biologie du Cancer et de l'Infection, Grenoble, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Commissariat à l'énergie atomique et aux énergies alternatives, Direction des Sciences du Vivant, Institut de Recherches en Technologies et Sciences pour le Vivant, Laboratoire Biologie du Cancer et de l'Infection, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff3">Université Joseph Fourier, Grenoble, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Joseph Fourier, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old 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France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Commissariat à l'énergie atomique et aux énergies alternatives, Direction des Sciences du Vivant, Institut de Recherches en Technologies et Sciences pour le Vivant, Laboratoire Biologie du Cancer et de l'Infection, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff3">Université Joseph Fourier, Grenoble, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Joseph Fourier, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement><settlement type="city">Grenoble</settlement></placeName><orgName type="university">Université Joseph Fourier</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23741013</idno><idno type="pmc">3724195</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3724195</idno><idno type="RBID">PMC:3724195</idno><idno type="doi">10.1182/blood-2012-12-472142</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">002C78</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002C78</idno><idno type="wicri:Area/Pmc/Curation">002C77</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002C77</idno><idno type="wicri:Area/Pmc/Checkpoint">002477</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002477</idno><idno type="wicri:Area/Ncbi/Merge">005995</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Bone morphogenetic protein 9 (BMP9) controls lymphatic vessel maturation and valve formation</title><author><name sortKey="Levet, Sandrine" sort="Levet, Sandrine" uniqKey="Levet S" first="Sandrine" last="Levet">Sandrine Levet</name><affiliation wicri:level="3"><nlm:aff id="aff1">INSERM U1036, Grenoble, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1036, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff2">Commissariat à l'énergie atomique et aux énergies alternatives, Direction des Sciences du Vivant, Institut de Recherches en Technologies et Sciences pour le Vivant, Laboratoire Biologie du Cancer et de l'Infection, Grenoble, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Commissariat à l'énergie atomique et aux énergies alternatives, Direction des Sciences du Vivant, Institut de Recherches en Technologies et Sciences pour le Vivant, Laboratoire Biologie du Cancer et de l'Infection, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff3">Université Joseph Fourier, Grenoble, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Joseph Fourier, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement><settlement type="city">Grenoble</settlement></placeName><orgName type="university">Université Joseph Fourier</orgName></affiliation></author><author><name sortKey="Ciais, Delphine" sort="Ciais, Delphine" uniqKey="Ciais D" first="Delphine" last="Ciais">Delphine Ciais</name><affiliation wicri:level="3"><nlm:aff id="aff1">INSERM U1036, Grenoble, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1036, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff2">Commissariat à l'énergie atomique et aux énergies alternatives, Direction des Sciences du Vivant, Institut de Recherches en Technologies et Sciences pour le Vivant, Laboratoire Biologie du Cancer et de l'Infection, Grenoble, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Commissariat à l'énergie atomique et aux énergies alternatives, Direction des Sciences du Vivant, Institut de Recherches en Technologies et Sciences pour le Vivant, Laboratoire Biologie du Cancer et de l'Infection, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff3">Université Joseph Fourier, Grenoble, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Joseph Fourier, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement><settlement type="city">Grenoble</settlement></placeName><orgName type="university">Université Joseph Fourier</orgName></affiliation></author><author><name sortKey="Merdzhanova, Galina" sort="Merdzhanova, Galina" uniqKey="Merdzhanova G" first="Galina" last="Merdzhanova">Galina Merdzhanova</name><affiliation wicri:level="3"><nlm:aff id="aff1">INSERM U1036, Grenoble, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1036, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff2">Commissariat à l'énergie atomique et aux énergies alternatives, Direction des Sciences du Vivant, Institut de Recherches en Technologies et Sciences pour le Vivant, Laboratoire Biologie du Cancer et de l'Infection, Grenoble, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Commissariat à l'énergie atomique et aux énergies alternatives, Direction des Sciences du Vivant, Institut de Recherches en Technologies et Sciences pour le Vivant, Laboratoire Biologie du Cancer et de l'Infection, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff3">Université Joseph Fourier, Grenoble, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Joseph Fourier, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement><settlement type="city">Grenoble</settlement></placeName><orgName type="university">Université Joseph Fourier</orgName></affiliation></author><author><name sortKey="Mallet, Christine" sort="Mallet, Christine" uniqKey="Mallet C" first="Christine" last="Mallet">Christine Mallet</name><affiliation wicri:level="3"><nlm:aff id="aff1">INSERM U1036, Grenoble, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1036, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff2">Commissariat à l'énergie atomique et aux énergies alternatives, Direction des Sciences du Vivant, Institut de Recherches en Technologies et Sciences pour le Vivant, Laboratoire Biologie du Cancer et de l'Infection, Grenoble, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Commissariat à l'énergie atomique et aux énergies alternatives, Direction des Sciences du Vivant, Institut de Recherches en Technologies et Sciences pour le Vivant, Laboratoire Biologie du Cancer et de l'Infection, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff3">Université Joseph Fourier, Grenoble, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Joseph Fourier, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement><settlement type="city">Grenoble</settlement></placeName><orgName type="university">Université Joseph Fourier</orgName></affiliation></author><author><name sortKey="Zimmers, Teresa A" sort="Zimmers, Teresa A" uniqKey="Zimmers T" first="Teresa A." last="Zimmers">Teresa A. Zimmers</name><affiliation wicri:level="2"><nlm:aff id="aff4">Department of Cancer Biology and Surgery, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Cancer Biology and Surgery, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia</wicri:cityArea></affiliation></author><author><name sortKey="Lee, Se Jin" sort="Lee, Se Jin" uniqKey="Lee S" first="Se-Jin" last="Lee">Se-Jin Lee</name><affiliation wicri:level="2"><nlm:aff wicri:cut="; and" id="aff5">Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Navarro, Fabrice P" sort="Navarro, Fabrice P" uniqKey="Navarro F" first="Fabrice P." last="Navarro">Fabrice P. Navarro</name><affiliation wicri:level="1"><nlm:aff id="aff6">Commissariat à l'énergie atomique et aux énergies alternatives, Laboratoire d'Electronique de Technologie de l'Information, Campus d'innovation pour les micro et nanotechnologies Grenoble, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Commissariat à l'énergie atomique et aux énergies alternatives, Laboratoire d'Electronique de Technologie de l'Information, Campus d'innovation pour les micro et nanotechnologies Grenoble</wicri:regionArea><wicri:noRegion>Campus d'innovation pour les micro et nanotechnologies Grenoble</wicri:noRegion><wicri:noRegion>Campus d'innovation pour les micro et nanotechnologies Grenoble</wicri:noRegion></affiliation></author><author><name sortKey="Texier, Isabelle" sort="Texier, Isabelle" uniqKey="Texier I" first="Isabelle" last="Texier">Isabelle Texier</name><affiliation wicri:level="1"><nlm:aff id="aff6">Commissariat à l'énergie atomique et aux énergies alternatives, Laboratoire d'Electronique de Technologie de l'Information, Campus d'innovation pour les micro et nanotechnologies Grenoble, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Commissariat à l'énergie atomique et aux énergies alternatives, Laboratoire d'Electronique de Technologie de l'Information, Campus d'innovation pour les micro et nanotechnologies Grenoble</wicri:regionArea><wicri:noRegion>Campus d'innovation pour les micro et nanotechnologies Grenoble</wicri:noRegion><wicri:noRegion>Campus d'innovation pour les micro et nanotechnologies Grenoble</wicri:noRegion></affiliation></author><author><name sortKey="Feige, Jean Jacques" sort="Feige, Jean Jacques" uniqKey="Feige J" first="Jean-Jacques" last="Feige">Jean-Jacques Feige</name><affiliation wicri:level="3"><nlm:aff id="aff1">INSERM U1036, Grenoble, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1036, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff2">Commissariat à l'énergie atomique et aux énergies alternatives, Direction des Sciences du Vivant, Institut de Recherches en Technologies et Sciences pour le Vivant, Laboratoire Biologie du Cancer et de l'Infection, Grenoble, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Commissariat à l'énergie atomique et aux énergies alternatives, Direction des Sciences du Vivant, Institut de Recherches en Technologies et Sciences pour le Vivant, Laboratoire Biologie du Cancer et de l'Infection, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff3">Université Joseph Fourier, Grenoble, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Joseph Fourier, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement><settlement type="city">Grenoble</settlement></placeName><orgName type="university">Université Joseph Fourier</orgName></affiliation></author><author><name sortKey="Bailly, Sabine" sort="Bailly, Sabine" uniqKey="Bailly S" first="Sabine" last="Bailly">Sabine Bailly</name><affiliation wicri:level="3"><nlm:aff id="aff1">INSERM U1036, Grenoble, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1036, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff2">Commissariat à l'énergie atomique et aux énergies alternatives, Direction des Sciences du Vivant, Institut de Recherches en Technologies et Sciences pour le Vivant, Laboratoire Biologie du Cancer et de l'Infection, Grenoble, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Commissariat à l'énergie atomique et aux énergies alternatives, Direction des Sciences du Vivant, Institut de Recherches en Technologies et Sciences pour le Vivant, Laboratoire Biologie du Cancer et de l'Infection, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff3">Université Joseph Fourier, Grenoble, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Joseph Fourier, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement><settlement type="city">Grenoble</settlement></placeName><orgName type="university">Université Joseph Fourier</orgName></affiliation></author><author><name sortKey="Vittet, Daniel" sort="Vittet, Daniel" uniqKey="Vittet D" first="Daniel" last="Vittet">Daniel Vittet</name><affiliation wicri:level="3"><nlm:aff id="aff1">INSERM U1036, Grenoble, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1036, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff2">Commissariat à l'énergie atomique et aux énergies alternatives, Direction des Sciences du Vivant, Institut de Recherches en Technologies et Sciences pour le Vivant, Laboratoire Biologie du Cancer et de l'Infection, Grenoble, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Commissariat à l'énergie atomique et aux énergies alternatives, Direction des Sciences du Vivant, Institut de Recherches en Technologies et Sciences pour le Vivant, Laboratoire Biologie du Cancer et de l'Infection, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff3">Université Joseph Fourier, Grenoble, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Joseph Fourier, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement><settlement type="city">Grenoble</settlement></placeName><orgName type="university">Université Joseph Fourier</orgName></affiliation></author></analytic><series><title level="j">Blood</title><idno type="ISSN">0006-4971</idno><idno type="eISSN">1528-0020</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Key Points</title><p><list list-type="bullet"><list-item><p>BMP9 is required for lymphatic valve formation.</p></list-item><list-item><p>Mice deficient in Bmp9 exhibit reduction in lymphatic draining efficiency.</p></list-item></list></p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Blood</journal-id><journal-id journal-id-type="iso-abbrev">Blood</journal-id><journal-id journal-id-type="hwp">bloodjournal</journal-id><journal-id journal-id-type="pmc">blood</journal-id><journal-id journal-id-type="publisher-id">Blood</journal-id><journal-title-group><journal-title>Blood</journal-title></journal-title-group><issn pub-type="ppub">0006-4971</issn><issn pub-type="epub">1528-0020</issn><publisher><publisher-name>American Society of Hematology</publisher-name><publisher-loc>Washington, DC</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">23741013</article-id><article-id pub-id-type="pmc">3724195</article-id><article-id pub-id-type="publisher-id">2012/472142</article-id><article-id pub-id-type="doi">10.1182/blood-2012-12-472142</article-id><article-categories><subj-group subj-group-type="heading"><subject>Vascular Biology</subject></subj-group></article-categories><title-group><article-title>Bone morphogenetic protein 9 (BMP9) controls lymphatic vessel maturation and valve formation</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Levet</surname><given-names>Sandrine</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff2">2</xref><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Ciais</surname><given-names>Delphine</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff2">2</xref><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Merdzhanova</surname><given-names>Galina</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff2">2</xref><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Mallet</surname><given-names>Christine</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff2">2</xref><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Zimmers</surname><given-names>Teresa A.</given-names></name><xref ref-type="aff" rid="aff4">4</xref></contrib><contrib contrib-type="author"><name><surname>Lee</surname><given-names>Se-Jin</given-names></name><xref ref-type="aff" rid="aff5">5</xref></contrib><contrib contrib-type="author"><name><surname>Navarro</surname><given-names>Fabrice P.</given-names></name><xref ref-type="aff" rid="aff6">6</xref></contrib><contrib contrib-type="author"><name><surname>Texier</surname><given-names>Isabelle</given-names></name><xref ref-type="aff" rid="aff6">6</xref></contrib><contrib contrib-type="author"><name><surname>Feige</surname><given-names>Jean-Jacques</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff2">2</xref><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Bailly</surname><given-names>Sabine</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff2">2</xref><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Vittet</surname><given-names>Daniel</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff2">2</xref><xref ref-type="aff" rid="aff3">3</xref></contrib><aff id="aff1"><label>1</label>INSERM U1036, Grenoble, France;</aff><aff id="aff2"><label>2</label>Commissariat à l'énergie atomique et aux énergies alternatives, Direction des Sciences du Vivant, Institut de Recherches en Technologies et Sciences pour le Vivant, Laboratoire Biologie du Cancer et de l'Infection, Grenoble, France;</aff><aff id="aff3"><label>3</label>Université Joseph Fourier, Grenoble, France;</aff><aff id="aff4"><label>4</label>Department of Cancer Biology and Surgery, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA;</aff><aff id="aff5"><label>5</label>Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD; and</aff><aff id="aff6"><label>6</label>Commissariat à l'énergie atomique et aux énergies alternatives, Laboratoire d'Electronique de Technologie de l'Information, Campus d'innovation pour les micro et nanotechnologies Grenoble, France</aff></contrib-group><author-notes><fn fn-type="equal"><p>S.L. and D.C. contributed equally to the study. S.B. and D.V. are co-last authors.</p></fn></author-notes><pub-date pub-type="ppub"><day>25</day><month>7</month><year>2013</year></pub-date><pub-date pub-type="epreprint"><day>05</day><month>6</month><year>2013</year></pub-date><pub-date pub-type="pmc-release"><day>25</day><month>7</month><year>2014</year></pub-date><pmc-comment> PMC Release delay is 12 months and
0 days and was based on the
<volume>122</volume><issue>4</issue><fpage>598</fpage><lpage>607</lpage><history><date date-type="received"><day>07</day><month>12</month><year>2012</year></date><date date-type="accepted"><day>02</day><month>6</month><year>2013</year></date></history><permissions><copyright-statement>© 2013 by The American Society of Hematology</copyright-statement><copyright-year>2013</copyright-year></permissions><self-uri xlink:title="pdf" xlink:type="simple" xlink:href="598.pdf"></self-uri><abstract abstract-type="executive-summary"><title>Key Points</title><p><list list-type="bullet"><list-item><p>BMP9 is required for lymphatic valve formation.</p></list-item><list-item><p>Mice deficient in Bmp9 exhibit reduction in lymphatic draining efficiency.</p></list-item></list></p></abstract><abstract><p>Lymphatic vessels are critical for the maintenance of tissue fluid homeostasis and their dysfunction contributes to several human diseases. The activin receptor-like kinase 1 (ALK1) is a transforming growth factor-β family type 1 receptor that is expressed on both blood and lymphatic endothelial cells (LECs). Its high-affinity ligand, bone morphogenetic protein 9 (BMP9), has been shown to be critical for retinal angiogenesis. The aim of this work was to investigate whether BMP9 could play a role in lymphatic development. We found that Bmp9 deficiency in mice causes abnormal lymphatic development. <italic>Bmp9</italic>-knockout (KO) pups presented hyperplastic mesenteric collecting vessels that maintained LYVE-1 expression. In accordance with this result, we found that BMP9 inhibited LYVE-1 expression in LECs in an ALK1-dependent manner. <italic>Bmp9</italic>-KO pups also presented a significant reduction in the number and in the maturation of mesenteric lymphatic valves at embryonic day 18.5 and at postnatal days 0 and 4. Interestingly, the expression of several genes known to be involved in valve formation (Foxc2, Connexin37, EphrinB2, and Neuropilin1) was upregulated by BMP9 in LECS. Finally, we demonstrated that <italic>Bmp9</italic>-KO neonates and adult mice had decreased lymphatic draining efficiency. These data identify BMP9 as an important extracellular regulator in the maturation of the lymphatic vascular network affecting valve development and lymphatic vessel function.</p></abstract><funding-group><award-group><funding-source id="CS100">National Institutes of Health</funding-source><award-id rid="CS100">HD35887/AR060636</award-id><award-id rid="CS100">HD35887</award-id><award-id rid="CS100">AR060636</award-id></award-group></funding-group><counts><page-count count="10"></page-count></counts></article-meta></front></pmc><affiliations><list><country><li>France</li><li>États-Unis</li></country><region><li>Auvergne-Rhône-Alpes</li><li>Maryland</li><li>Pennsylvanie</li><li>Rhône-Alpes</li></region><settlement><li>Grenoble</li></settlement><orgName><li>Université Joseph Fourier</li></orgName></list><tree><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Levet, Sandrine" sort="Levet, Sandrine" uniqKey="Levet S" first="Sandrine" last="Levet">Sandrine Levet</name></region><name sortKey="Bailly, Sabine" sort="Bailly, Sabine" uniqKey="Bailly S" first="Sabine" last="Bailly">Sabine Bailly</name><name sortKey="Bailly, Sabine" sort="Bailly, Sabine" uniqKey="Bailly S" first="Sabine" last="Bailly">Sabine Bailly</name><name sortKey="Bailly, Sabine" sort="Bailly, Sabine" uniqKey="Bailly S" first="Sabine" last="Bailly">Sabine Bailly</name><name sortKey="Ciais, Delphine" sort="Ciais, Delphine" uniqKey="Ciais D" first="Delphine" last="Ciais">Delphine Ciais</name><name sortKey="Ciais, Delphine" sort="Ciais, Delphine" uniqKey="Ciais D" first="Delphine" last="Ciais">Delphine Ciais</name><name sortKey="Ciais, Delphine" sort="Ciais, Delphine" uniqKey="Ciais D" first="Delphine" last="Ciais">Delphine Ciais</name><name sortKey="Feige, Jean Jacques" sort="Feige, Jean Jacques" uniqKey="Feige J" first="Jean-Jacques" last="Feige">Jean-Jacques Feige</name><name sortKey="Feige, Jean Jacques" sort="Feige, Jean Jacques" uniqKey="Feige J" first="Jean-Jacques" last="Feige">Jean-Jacques Feige</name><name sortKey="Feige, Jean Jacques" sort="Feige, Jean Jacques" uniqKey="Feige J" first="Jean-Jacques" last="Feige">Jean-Jacques Feige</name><name sortKey="Levet, Sandrine" sort="Levet, Sandrine" uniqKey="Levet S" first="Sandrine" last="Levet">Sandrine Levet</name><name sortKey="Levet, Sandrine" sort="Levet, Sandrine" uniqKey="Levet S" first="Sandrine" last="Levet">Sandrine Levet</name><name sortKey="Mallet, Christine" sort="Mallet, Christine" uniqKey="Mallet C" first="Christine" last="Mallet">Christine Mallet</name><name sortKey="Mallet, Christine" sort="Mallet, Christine" uniqKey="Mallet C" first="Christine" last="Mallet">Christine Mallet</name><name sortKey="Mallet, Christine" sort="Mallet, Christine" uniqKey="Mallet C" first="Christine" last="Mallet">Christine Mallet</name><name sortKey="Merdzhanova, Galina" sort="Merdzhanova, Galina" uniqKey="Merdzhanova G" first="Galina" last="Merdzhanova">Galina Merdzhanova</name><name sortKey="Merdzhanova, Galina" sort="Merdzhanova, Galina" uniqKey="Merdzhanova G" first="Galina" last="Merdzhanova">Galina Merdzhanova</name><name sortKey="Merdzhanova, Galina" sort="Merdzhanova, Galina" uniqKey="Merdzhanova G" first="Galina" last="Merdzhanova">Galina Merdzhanova</name><name sortKey="Navarro, Fabrice P" sort="Navarro, Fabrice P" uniqKey="Navarro F" first="Fabrice P." last="Navarro">Fabrice P. Navarro</name><name sortKey="Texier, Isabelle" sort="Texier, Isabelle" uniqKey="Texier I" first="Isabelle" last="Texier">Isabelle Texier</name><name sortKey="Vittet, Daniel" sort="Vittet, Daniel" uniqKey="Vittet D" first="Daniel" last="Vittet">Daniel Vittet</name><name sortKey="Vittet, Daniel" sort="Vittet, Daniel" uniqKey="Vittet D" first="Daniel" last="Vittet">Daniel Vittet</name><name sortKey="Vittet, Daniel" sort="Vittet, Daniel" uniqKey="Vittet D" first="Daniel" last="Vittet">Daniel Vittet</name></country><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Zimmers, Teresa A" sort="Zimmers, Teresa A" uniqKey="Zimmers T" first="Teresa A." last="Zimmers">Teresa A. Zimmers</name></region><name sortKey="Lee, Se Jin" sort="Lee, Se Jin" uniqKey="Lee S" first="Se-Jin" last="Lee">Se-Jin Lee</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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