LymphedemaV1, Pmc, Corpus, bibRecord, 002C78

Bone morphogenetic protein 9 (BMP9) controls lymphatic vessel maturation and valve formation

Identifieur interne : 002C78 ( Pmc/Corpus ); précédent : 002C77; suivant : 002C79

Bone morphogenetic protein 9 (BMP9) controls lymphatic vessel maturation and valve formation

Auteurs : Sandrine Levet ; Delphine Ciais ; Galina Merdzhanova ; Christine Mallet ; Teresa A. Zimmers ; Se-Jin Lee ; Fabrice P. Navarro ; Isabelle Texier ; Jean-Jacques Feige ; Sabine Bailly ; Daniel Vittet

Source :

Blood [ 0006-4971 ] ; 2013.

RBID : PMC:3724195

Abstract

Key Points

BMP9 is required for lymphatic valve formation.

Mice deficient in Bmp9 exhibit reduction in lymphatic draining efficiency.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3724195

DOI: 10.1182/blood-2012-12-472142
PubMed: 23741013
PubMed Central: 3724195

Links to Exploration step

PMC:3724195

Le document en format XML

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<author><name sortKey="Levet, Sandrine" sort="Levet, Sandrine" uniqKey="Levet S" first="Sandrine" last="Levet">Sandrine Levet</name>
<affiliation><nlm:aff id="aff1">INSERM U1036, Grenoble, France;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff2">Commissariat à l'énergie atomique et aux énergies alternatives, Direction des Sciences du Vivant, Institut de Recherches en Technologies et Sciences pour le Vivant, Laboratoire Biologie du Cancer et de l'Infection, Grenoble, France;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff3">Université Joseph Fourier, Grenoble, France;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ciais, Delphine" sort="Ciais, Delphine" uniqKey="Ciais D" first="Delphine" last="Ciais">Delphine Ciais</name>
<affiliation><nlm:aff id="aff1">INSERM U1036, Grenoble, France;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff2">Commissariat à l'énergie atomique et aux énergies alternatives, Direction des Sciences du Vivant, Institut de Recherches en Technologies et Sciences pour le Vivant, Laboratoire Biologie du Cancer et de l'Infection, Grenoble, France;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff3">Université Joseph Fourier, Grenoble, France;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Merdzhanova, Galina" sort="Merdzhanova, Galina" uniqKey="Merdzhanova G" first="Galina" last="Merdzhanova">Galina Merdzhanova</name>
<affiliation><nlm:aff id="aff1">INSERM U1036, Grenoble, France;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff2">Commissariat à l'énergie atomique et aux énergies alternatives, Direction des Sciences du Vivant, Institut de Recherches en Technologies et Sciences pour le Vivant, Laboratoire Biologie du Cancer et de l'Infection, Grenoble, France;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff3">Université Joseph Fourier, Grenoble, France;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mallet, Christine" sort="Mallet, Christine" uniqKey="Mallet C" first="Christine" last="Mallet">Christine Mallet</name>
<affiliation><nlm:aff id="aff1">INSERM U1036, Grenoble, France;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff2">Commissariat à l'énergie atomique et aux énergies alternatives, Direction des Sciences du Vivant, Institut de Recherches en Technologies et Sciences pour le Vivant, Laboratoire Biologie du Cancer et de l'Infection, Grenoble, France;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff3">Université Joseph Fourier, Grenoble, France;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Zimmers, Teresa A" sort="Zimmers, Teresa A" uniqKey="Zimmers T" first="Teresa A." last="Zimmers">Teresa A. Zimmers</name>
<affiliation><nlm:aff id="aff4">Department of Cancer Biology and Surgery, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lee, Se Jin" sort="Lee, Se Jin" uniqKey="Lee S" first="Se-Jin" last="Lee">Se-Jin Lee</name>
<affiliation><nlm:aff wicri:cut="; and" id="aff5">Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Navarro, Fabrice P" sort="Navarro, Fabrice P" uniqKey="Navarro F" first="Fabrice P." last="Navarro">Fabrice P. Navarro</name>
<affiliation><nlm:aff id="aff6">Commissariat à l'énergie atomique et aux énergies alternatives, Laboratoire d'Electronique de Technologie de l'Information, Campus d'innovation pour les micro et nanotechnologies Grenoble, France</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Texier, Isabelle" sort="Texier, Isabelle" uniqKey="Texier I" first="Isabelle" last="Texier">Isabelle Texier</name>
<affiliation><nlm:aff id="aff6">Commissariat à l'énergie atomique et aux énergies alternatives, Laboratoire d'Electronique de Technologie de l'Information, Campus d'innovation pour les micro et nanotechnologies Grenoble, France</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Feige, Jean Jacques" sort="Feige, Jean Jacques" uniqKey="Feige J" first="Jean-Jacques" last="Feige">Jean-Jacques Feige</name>
<affiliation><nlm:aff id="aff1">INSERM U1036, Grenoble, France;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff2">Commissariat à l'énergie atomique et aux énergies alternatives, Direction des Sciences du Vivant, Institut de Recherches en Technologies et Sciences pour le Vivant, Laboratoire Biologie du Cancer et de l'Infection, Grenoble, France;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff3">Université Joseph Fourier, Grenoble, France;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Bailly, Sabine" sort="Bailly, Sabine" uniqKey="Bailly S" first="Sabine" last="Bailly">Sabine Bailly</name>
<affiliation><nlm:aff id="aff1">INSERM U1036, Grenoble, France;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff2">Commissariat à l'énergie atomique et aux énergies alternatives, Direction des Sciences du Vivant, Institut de Recherches en Technologies et Sciences pour le Vivant, Laboratoire Biologie du Cancer et de l'Infection, Grenoble, France;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff3">Université Joseph Fourier, Grenoble, France;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Vittet, Daniel" sort="Vittet, Daniel" uniqKey="Vittet D" first="Daniel" last="Vittet">Daniel Vittet</name>
<affiliation><nlm:aff id="aff1">INSERM U1036, Grenoble, France;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff2">Commissariat à l'énergie atomique et aux énergies alternatives, Direction des Sciences du Vivant, Institut de Recherches en Technologies et Sciences pour le Vivant, Laboratoire Biologie du Cancer et de l'Infection, Grenoble, France;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff3">Université Joseph Fourier, Grenoble, France;</nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">23741013</idno>
<idno type="pmc">3724195</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3724195</idno>
<idno type="RBID">PMC:3724195</idno>
<idno type="doi">10.1182/blood-2012-12-472142</idno>
<date when="2013">2013</date>
<idno type="wicri:Area/Pmc/Corpus">002C78</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002C78</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Bone morphogenetic protein 9 (BMP9) controls lymphatic vessel maturation and valve formation</title>
<author><name sortKey="Levet, Sandrine" sort="Levet, Sandrine" uniqKey="Levet S" first="Sandrine" last="Levet">Sandrine Levet</name>
<affiliation><nlm:aff id="aff1">INSERM U1036, Grenoble, France;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff2">Commissariat à l'énergie atomique et aux énergies alternatives, Direction des Sciences du Vivant, Institut de Recherches en Technologies et Sciences pour le Vivant, Laboratoire Biologie du Cancer et de l'Infection, Grenoble, France;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff3">Université Joseph Fourier, Grenoble, France;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ciais, Delphine" sort="Ciais, Delphine" uniqKey="Ciais D" first="Delphine" last="Ciais">Delphine Ciais</name>
<affiliation><nlm:aff id="aff1">INSERM U1036, Grenoble, France;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff2">Commissariat à l'énergie atomique et aux énergies alternatives, Direction des Sciences du Vivant, Institut de Recherches en Technologies et Sciences pour le Vivant, Laboratoire Biologie du Cancer et de l'Infection, Grenoble, France;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff3">Université Joseph Fourier, Grenoble, France;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Merdzhanova, Galina" sort="Merdzhanova, Galina" uniqKey="Merdzhanova G" first="Galina" last="Merdzhanova">Galina Merdzhanova</name>
<affiliation><nlm:aff id="aff1">INSERM U1036, Grenoble, France;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff2">Commissariat à l'énergie atomique et aux énergies alternatives, Direction des Sciences du Vivant, Institut de Recherches en Technologies et Sciences pour le Vivant, Laboratoire Biologie du Cancer et de l'Infection, Grenoble, France;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff3">Université Joseph Fourier, Grenoble, France;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mallet, Christine" sort="Mallet, Christine" uniqKey="Mallet C" first="Christine" last="Mallet">Christine Mallet</name>
<affiliation><nlm:aff id="aff1">INSERM U1036, Grenoble, France;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff2">Commissariat à l'énergie atomique et aux énergies alternatives, Direction des Sciences du Vivant, Institut de Recherches en Technologies et Sciences pour le Vivant, Laboratoire Biologie du Cancer et de l'Infection, Grenoble, France;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff3">Université Joseph Fourier, Grenoble, France;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Zimmers, Teresa A" sort="Zimmers, Teresa A" uniqKey="Zimmers T" first="Teresa A." last="Zimmers">Teresa A. Zimmers</name>
<affiliation><nlm:aff id="aff4">Department of Cancer Biology and Surgery, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lee, Se Jin" sort="Lee, Se Jin" uniqKey="Lee S" first="Se-Jin" last="Lee">Se-Jin Lee</name>
<affiliation><nlm:aff wicri:cut="; and" id="aff5">Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Navarro, Fabrice P" sort="Navarro, Fabrice P" uniqKey="Navarro F" first="Fabrice P." last="Navarro">Fabrice P. Navarro</name>
<affiliation><nlm:aff id="aff6">Commissariat à l'énergie atomique et aux énergies alternatives, Laboratoire d'Electronique de Technologie de l'Information, Campus d'innovation pour les micro et nanotechnologies Grenoble, France</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Texier, Isabelle" sort="Texier, Isabelle" uniqKey="Texier I" first="Isabelle" last="Texier">Isabelle Texier</name>
<affiliation><nlm:aff id="aff6">Commissariat à l'énergie atomique et aux énergies alternatives, Laboratoire d'Electronique de Technologie de l'Information, Campus d'innovation pour les micro et nanotechnologies Grenoble, France</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Feige, Jean Jacques" sort="Feige, Jean Jacques" uniqKey="Feige J" first="Jean-Jacques" last="Feige">Jean-Jacques Feige</name>
<affiliation><nlm:aff id="aff1">INSERM U1036, Grenoble, France;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff2">Commissariat à l'énergie atomique et aux énergies alternatives, Direction des Sciences du Vivant, Institut de Recherches en Technologies et Sciences pour le Vivant, Laboratoire Biologie du Cancer et de l'Infection, Grenoble, France;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff3">Université Joseph Fourier, Grenoble, France;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Bailly, Sabine" sort="Bailly, Sabine" uniqKey="Bailly S" first="Sabine" last="Bailly">Sabine Bailly</name>
<affiliation><nlm:aff id="aff1">INSERM U1036, Grenoble, France;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff2">Commissariat à l'énergie atomique et aux énergies alternatives, Direction des Sciences du Vivant, Institut de Recherches en Technologies et Sciences pour le Vivant, Laboratoire Biologie du Cancer et de l'Infection, Grenoble, France;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff3">Université Joseph Fourier, Grenoble, France;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Vittet, Daniel" sort="Vittet, Daniel" uniqKey="Vittet D" first="Daniel" last="Vittet">Daniel Vittet</name>
<affiliation><nlm:aff id="aff1">INSERM U1036, Grenoble, France;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff2">Commissariat à l'énergie atomique et aux énergies alternatives, Direction des Sciences du Vivant, Institut de Recherches en Technologies et Sciences pour le Vivant, Laboratoire Biologie du Cancer et de l'Infection, Grenoble, France;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff3">Université Joseph Fourier, Grenoble, France;</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Blood</title>
<idno type="ISSN">0006-4971</idno>
<idno type="eISSN">1528-0020</idno>
<imprint><date when="2013">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><title>Key Points</title>
<p><list list-type="bullet"><list-item><p>BMP9 is required for lymphatic valve formation.</p>
</list-item>
<list-item><p>Mice deficient in Bmp9 exhibit reduction in lymphatic draining efficiency.</p>
</list-item>
</list>
</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
  <front><journal-meta><journal-id journal-id-type="nlm-ta">Blood</journal-id>
<journal-id journal-id-type="iso-abbrev">Blood</journal-id>
<journal-id journal-id-type="hwp">bloodjournal</journal-id>
<journal-id journal-id-type="pmc">blood</journal-id>
<journal-id journal-id-type="publisher-id">Blood</journal-id>
<journal-title-group><journal-title>Blood</journal-title>
</journal-title-group>
<issn pub-type="ppub">0006-4971</issn>
<issn pub-type="epub">1528-0020</issn>
<publisher><publisher-name>American Society of Hematology</publisher-name>
<publisher-loc>Washington, DC</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">23741013</article-id>
<article-id pub-id-type="pmc">3724195</article-id>
<article-id pub-id-type="publisher-id">2012/472142</article-id>
<article-id pub-id-type="doi">10.1182/blood-2012-12-472142</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Vascular Biology</subject>
</subj-group>
</article-categories>
<title-group><article-title>Bone morphogenetic protein 9 (BMP9) controls lymphatic vessel maturation and valve formation</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Levet</surname>
<given-names>Sandrine</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
<xref ref-type="aff" rid="aff2">2</xref>
<xref ref-type="aff" rid="aff3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ciais</surname>
<given-names>Delphine</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
<xref ref-type="aff" rid="aff2">2</xref>
<xref ref-type="aff" rid="aff3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Merdzhanova</surname>
<given-names>Galina</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
<xref ref-type="aff" rid="aff2">2</xref>
<xref ref-type="aff" rid="aff3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Mallet</surname>
<given-names>Christine</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
<xref ref-type="aff" rid="aff2">2</xref>
<xref ref-type="aff" rid="aff3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Zimmers</surname>
<given-names>Teresa A.</given-names>
</name>
<xref ref-type="aff" rid="aff4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lee</surname>
<given-names>Se-Jin</given-names>
</name>
<xref ref-type="aff" rid="aff5">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Navarro</surname>
<given-names>Fabrice P.</given-names>
</name>
<xref ref-type="aff" rid="aff6">6</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Texier</surname>
<given-names>Isabelle</given-names>
</name>
<xref ref-type="aff" rid="aff6">6</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Feige</surname>
<given-names>Jean-Jacques</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
<xref ref-type="aff" rid="aff2">2</xref>
<xref ref-type="aff" rid="aff3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bailly</surname>
<given-names>Sabine</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
<xref ref-type="aff" rid="aff2">2</xref>
<xref ref-type="aff" rid="aff3">3</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Vittet</surname>
<given-names>Daniel</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
<xref ref-type="aff" rid="aff2">2</xref>
<xref ref-type="aff" rid="aff3">3</xref>
</contrib>
<aff id="aff1"><label>1</label>
INSERM U1036, Grenoble, France;</aff>
<aff id="aff2"><label>2</label>
Commissariat à l'énergie atomique et aux énergies alternatives, Direction des Sciences du Vivant, Institut de Recherches en Technologies et Sciences pour le Vivant, Laboratoire Biologie du Cancer et de l'Infection, Grenoble, France;</aff>
<aff id="aff3"><label>3</label>
Université Joseph Fourier, Grenoble, France;</aff>
<aff id="aff4"><label>4</label>
Department of Cancer Biology and Surgery, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA;</aff>
<aff id="aff5"><label>5</label>
Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD; and</aff>
<aff id="aff6"><label>6</label>
Commissariat à l'énergie atomique et aux énergies alternatives, Laboratoire d'Electronique de Technologie de l'Information, Campus d'innovation pour les micro et nanotechnologies Grenoble, France</aff>
</contrib-group>
<author-notes><fn fn-type="equal"><p>S.L. and D.C. contributed equally to the study. S.B. and D.V. are co-last authors.</p>
</fn>
</author-notes>
<pub-date pub-type="ppub"><day>25</day>
<month>7</month>
<year>2013</year>
</pub-date>
<pub-date pub-type="epreprint"><day>05</day>
<month>6</month>
<year>2013</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>25</day>
<month>7</month>
<year>2014</year>
</pub-date>
<pmc-comment> PMC Release delay is 12 months and 
 						0 days and was based on the . </pmc-comment>
      <volume>122</volume>
<issue>4</issue>
<fpage>598</fpage>
<lpage>607</lpage>
<history><date date-type="received"><day>07</day>
<month>12</month>
<year>2012</year>
</date>
<date date-type="accepted"><day>02</day>
<month>6</month>
<year>2013</year>
</date>
</history>
<permissions><copyright-statement>© 2013 by The American Society of Hematology</copyright-statement>
<copyright-year>2013</copyright-year>
</permissions>
<self-uri xlink:title="pdf" xlink:type="simple" xlink:href="598.pdf"></self-uri>
<abstract abstract-type="executive-summary"><title>Key Points</title>
<p><list list-type="bullet"><list-item><p>BMP9 is required for lymphatic valve formation.</p>
</list-item>
<list-item><p>Mice deficient in Bmp9 exhibit reduction in lymphatic draining efficiency.</p>
</list-item>
</list>
</p>
</abstract>
<abstract><p>Lymphatic vessels are critical for the maintenance of tissue fluid homeostasis and their dysfunction contributes to several human diseases. The activin receptor-like kinase 1 (ALK1) is a transforming growth factor-β family type 1 receptor that is expressed on both blood and lymphatic endothelial cells (LECs). Its high-affinity ligand, bone morphogenetic protein 9 (BMP9), has been shown to be critical for retinal angiogenesis. The aim of this work was to investigate whether BMP9 could play a role in lymphatic development. We found that Bmp9 deficiency in mice causes abnormal lymphatic development. <italic>Bmp9</italic>
-knockout (KO) pups presented hyperplastic mesenteric collecting vessels that maintained LYVE-1 expression. In accordance with this result, we found that BMP9 inhibited LYVE-1 expression in LECs in an ALK1-dependent manner. <italic>Bmp9</italic>
-KO pups also presented a significant reduction in the number and in the maturation of mesenteric lymphatic valves at embryonic day 18.5 and at postnatal days 0 and 4. Interestingly, the expression of several genes known to be involved in valve formation (Foxc2, Connexin37, EphrinB2, and Neuropilin1) was upregulated by BMP9 in LECS. Finally, we demonstrated that <italic>Bmp9</italic>
-KO neonates and adult mice had decreased lymphatic draining efficiency. These data identify BMP9 as an important extracellular regulator in the maturation of the lymphatic vascular network affecting valve development and lymphatic vessel function.</p>
</abstract>
<funding-group><award-group><funding-source id="CS100">National Institutes of Health</funding-source>
<award-id rid="CS100">HD35887/AR060636</award-id>
<award-id rid="CS100">HD35887</award-id>
<award-id rid="CS100">AR060636</award-id>
</award-group>
</funding-group>
<counts><page-count count="10"></page-count>
</counts>
</article-meta>
</front>
</pmc>
</record>

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Serveur d'exploration sur le lymphœdème

Bone morphogenetic protein 9 (BMP9) controls lymphatic vessel maturation and valve formation

Bone morphogenetic protein 9 (BMP9) controls lymphatic vessel maturation and valve formation

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