LymphedemaV1, Ncbi, Merge, bibRecord, 005859

Regulation of Endothelial Cell Differentiation and Specification

Identifieur interne : 005859 ( Ncbi/Merge ); précédent : 005858; suivant : 005860

Regulation of Endothelial Cell Differentiation and Specification

Auteurs : Kathrina L. Marcelo [États-Unis] ; Lauren C. Goldie [États-Unis] ; Karen K. Hirschi [États-Unis]

Source :

Circulation research [ 0009-7330 ] ; 2013.

RBID : PMC:3768127

Abstract

The circulatory system is the first organ system to develop in the vertebrate embryo and is critical throughout gestation for the delivery of oxygen and nutrients to, as well as removal of metabolic waste products from, growing tissues. Endothelial cells, which constitute the luminal layer of all blood and lymphatic vessels, emerge de novo from the mesoderm in a process known as vasculogenesis. The vascular plexus that is initially formed is then remodeled and refined via proliferation, migration and sprouting of endothelial cells to form new vessels from pre-existing ones during angiogenesis. Mural cells are also recruited by endothelial cells to form the surrounding vessel wall. During this vascular remodeling process, primordial endothelial cells are specialized to acquire arterial, venous, and blood-forming hemogenic phenotypes and functions. A subset of venous endothelium is also specialized to become lymphatic endothelium later in development. The specialization of all endothelial cell subtypes requires extrinsic signals and intrinsic regulatory events, which will be discussed in this review.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3768127

DOI: 10.1161/CIRCRESAHA.113.300506
PubMed: 23620236
PubMed Central: 3768127

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to stream Pmc, to step Curation: 003239
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PMC:3768127

Le document en format XML

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<series><title level="j">Circulation research</title>
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<front><div type="abstract" xml:lang="en"><p id="P1">The circulatory system is the first organ system to develop in the vertebrate embryo and is critical throughout gestation for the delivery of oxygen and nutrients to, as well as removal of metabolic waste products from, growing tissues. Endothelial cells, which constitute the luminal layer of all blood and lymphatic vessels, emerge <italic>de novo</italic>
 from the mesoderm in a process known as vasculogenesis. The vascular plexus that is initially formed is then remodeled and refined via proliferation, migration and sprouting of endothelial cells to form new vessels from pre-existing ones during angiogenesis. Mural cells are also recruited by endothelial cells to form the surrounding vessel wall. During this vascular remodeling process, primordial endothelial cells are specialized to acquire arterial, venous, and blood-forming hemogenic phenotypes and functions. A subset of venous endothelium is also specialized to become lymphatic endothelium later in development. The specialization of all endothelial cell subtypes requires extrinsic signals and intrinsic regulatory events, which will be discussed in this review.</p>
</div>
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<title-group><article-title>Regulation of Endothelial Cell Differentiation and Specification</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Marcelo</surname>
<given-names>Kathrina L.</given-names>
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<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A3">3</xref>
<xref ref-type="aff" rid="A4">4</xref>
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<contrib contrib-type="author"><name><surname>Goldie</surname>
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<contrib contrib-type="author"><name><surname>Hirschi</surname>
<given-names>Karen K.</given-names>
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<aff id="A1"><label>1</label>
Interdepartmental Program in Developmental Biology, One Baylor Plaza, Houston, TX 77030</aff>
<aff id="A2"><label>2</label>
Department of Pediatrics, One Baylor Plaza, Houston, TX 77030</aff>
<aff id="A3"><label>3</label>
Center for Cell and Gene Therapy, One Baylor Plaza, Houston, TX 77030</aff>
<aff id="A4"><label>4</label>
USDA/ARS Children’s Nutrition Research Center, One Baylor Plaza, Houston, TX 77030</aff>
<aff id="A5"><label>5</label>
Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030</aff>
<aff id="A6"><label>6</label>
Yale Cardiovascular Research Center and Yale Stem Cell Center, Yale University School of Medicine, 300 George Street, New Haven, CT 06511</aff>
<author-notes><corresp id="FN1">Corresponding Author Information: Dr. Karen K. Hirschi, Yale Cardiovascular Research Center and Yale Stem Cell Center, Yale University School of Medicine, 300 George Street, New Haven, CT 06511, Telephone number: (203) 737-4533, Fax number: (203) 785-7567, <email>karen.hirschi@yale.edu</email>
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<pub-date pub-type="pmc-release"><day>26</day>
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<volume>112</volume>
<issue>9</issue>
<fpage>1272</fpage>
<lpage>1287</lpage>
<abstract><p id="P1">The circulatory system is the first organ system to develop in the vertebrate embryo and is critical throughout gestation for the delivery of oxygen and nutrients to, as well as removal of metabolic waste products from, growing tissues. Endothelial cells, which constitute the luminal layer of all blood and lymphatic vessels, emerge <italic>de novo</italic>
 from the mesoderm in a process known as vasculogenesis. The vascular plexus that is initially formed is then remodeled and refined via proliferation, migration and sprouting of endothelial cells to form new vessels from pre-existing ones during angiogenesis. Mural cells are also recruited by endothelial cells to form the surrounding vessel wall. During this vascular remodeling process, primordial endothelial cells are specialized to acquire arterial, venous, and blood-forming hemogenic phenotypes and functions. A subset of venous endothelium is also specialized to become lymphatic endothelium later in development. The specialization of all endothelial cell subtypes requires extrinsic signals and intrinsic regulatory events, which will be discussed in this review.</p>
</abstract>
<kwd-group><kwd>endothelial cells</kwd>
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<affiliations><list><country><li>États-Unis</li>
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<name sortKey="Goldie, Lauren C" sort="Goldie, Lauren C" uniqKey="Goldie L" first="Lauren C." last="Goldie">Lauren C. Goldie</name>
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<name sortKey="Hirschi, Karen K" sort="Hirschi, Karen K" uniqKey="Hirschi K" first="Karen K." last="Hirschi">Karen K. Hirschi</name>
<name sortKey="Hirschi, Karen K" sort="Hirschi, Karen K" uniqKey="Hirschi K" first="Karen K." last="Hirschi">Karen K. Hirschi</name>
<name sortKey="Hirschi, Karen K" sort="Hirschi, Karen K" uniqKey="Hirschi K" first="Karen K." last="Hirschi">Karen K. Hirschi</name>
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<name sortKey="Marcelo, Kathrina L" sort="Marcelo, Kathrina L" uniqKey="Marcelo K" first="Kathrina L." last="Marcelo">Kathrina L. Marcelo</name>
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Regulation of Endothelial Cell Differentiation and Specification

Regulation of Endothelial Cell Differentiation and Specification

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