The Alberta moving beyond breast cancer (AMBER) cohort study: a prospective study of physical activity and health-related fitness in breast cancer survivors
Identifieur interne : 005312 ( Ncbi/Merge ); précédent : 005311; suivant : 005313The Alberta moving beyond breast cancer (AMBER) cohort study: a prospective study of physical activity and health-related fitness in breast cancer survivors
Auteurs : Kerry S. Courneya [Canada] ; Jeff K. Vallance [Canada] ; S Nicole Culos-Reed [Canada] ; Margaret L. Mcneely [Canada] ; Gordon J. Bell [Canada] ; John R. Mackey [Canada] ; Yutaka Yasui [Canada] ; Yan Yuan [Canada] ; Charles E. Matthews [États-Unis] ; David Cw Lau [Canada] ; Diane Cook [Canada] ; Christine M. Friedenreich [Canada]Source :
- BMC Cancer [ 1471-2407 ] ; 2012.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- geographic : Alberta.
- complications : Breast Neoplasms.
- psychology : Breast Neoplasms.
- Cohort Studies, Exercise, Female, Health Status, Humans, Physical Fitness, Quality of Life, Research Design, Self Report, Survivors.
Abstract
Limited research has examined the association between physical activity, health-related fitness, and disease outcomes in breast cancer survivors. Here, we present the rationale and design of the
The AMBER Study will enroll 1500 newly diagnosed, incident, stage I-IIIc breast cancer survivors in Alberta, Canada over a 5 year period. Assessments will be made at baseline (within 90 days of surgery), 1 year, and 3 years consisting of objective and self-reported measurements of physical activity, health-related fitness, blood collection, lymphedema, patient-reported outcomes, and determinants of physical activity. A final assessment at 5 years will measure patient-reported data only. The cohort members will be followed for an additional 5 years for disease outcomes.
The AMBER cohort will answer key questions related to physical activity and health-related fitness in breast cancer survivors including: (1) the independent and interactive associations of physical activity and health-related fitness with disease outcomes (e.g., recurrence, breast cancer-specific mortality, overall survival), treatment completion rates, symptoms and side effects (e.g., pain, lymphedema, fatigue, neuropathy), quality of life, and psychosocial functioning (e.g., anxiety, depression, self-esteem, happiness), (2) the determinants of physical activity and health-related fitness including demographic, medical, social cognitive, and environmental variables, (3) the mediators of any observed associations between physical activity, health-related fitness, and health outcomes including biological, functional, and psychosocial, and (4) the moderators of any observed associations including demographic, medical, and biological/disease factors. Taken together, these data will provide a comprehensive inquiry into the outcomes, determinants, mechanisms, and moderators of physical activity and health-related fitness in breast cancer survivors.
Url:
DOI: 10.1186/1471-2407-12-525
PubMed: 23153358
PubMed Central: 3534483
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<term>Breast Neoplasms (complications)</term>
<term>Breast Neoplasms (psychology)</term>
<term>Cohort Studies</term>
<term>Exercise</term>
<term>Female</term>
<term>Health Status</term>
<term>Humans</term>
<term>Physical Fitness</term>
<term>Quality of Life</term>
<term>Research Design</term>
<term>Self Report</term>
<term>Survivors</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Alberta</term>
<term>Aptitude physique</term>
<term>Autorapport</term>
<term>Exercice physique</term>
<term>Femelle</term>
<term>Humains</term>
<term>Plan de recherche</term>
<term>Qualité de vie</term>
<term>Survivants</term>
<term>Tumeurs du sein ()</term>
<term>Tumeurs du sein (psychologie)</term>
<term>État de santé</term>
<term>Études de cohortes</term>
</keywords>
<keywords scheme="MESH" type="geographic" xml:lang="en"><term>Alberta</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Breast Neoplasms</term>
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<keywords scheme="MESH" qualifier="psychologie" xml:lang="fr"><term>Tumeurs du sein</term>
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<keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Breast Neoplasms</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Cohort Studies</term>
<term>Exercise</term>
<term>Female</term>
<term>Health Status</term>
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<term>Physical Fitness</term>
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<term>Research Design</term>
<term>Self Report</term>
<term>Survivors</term>
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<term>Aptitude physique</term>
<term>Autorapport</term>
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<term>Femelle</term>
<term>Humains</term>
<term>Plan de recherche</term>
<term>Qualité de vie</term>
<term>Survivants</term>
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<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>Limited research has examined the association between physical activity, health-related fitness, and disease outcomes in breast cancer survivors. Here, we present the rationale and design of the <underline>A</underline>
lberta <underline>M</underline>
oving <underline>Be</underline>
yond B<underline>r</underline>
east Cancer (AMBER) Study, a prospective cohort study designed specifically to examine the role of physical activity and health-related fitness in breast cancer survivorship from the time of diagnosis and for the balance of life. The AMBER Study will examine the role of physical activity and health-related fitness in facilitating treatment completion, alleviating treatment side effects, hastening recovery after treatments, improving long term quality of life, and reducing the risks of disease recurrence, other chronic diseases, and premature death.</p>
</sec>
<sec><title>Methods/Design</title>
<p>The AMBER Study will enroll 1500 newly diagnosed, incident, stage I-IIIc breast cancer survivors in Alberta, Canada over a 5 year period. Assessments will be made at baseline (within 90 days of surgery), 1 year, and 3 years consisting of objective and self-reported measurements of physical activity, health-related fitness, blood collection, lymphedema, patient-reported outcomes, and determinants of physical activity. A final assessment at 5 years will measure patient-reported data only. The cohort members will be followed for an additional 5 years for disease outcomes.</p>
</sec>
<sec><title>Discussion</title>
<p>The AMBER cohort will answer key questions related to physical activity and health-related fitness in breast cancer survivors including: (1) the independent and interactive associations of physical activity and health-related fitness with disease outcomes (e.g., recurrence, breast cancer-specific mortality, overall survival), treatment completion rates, symptoms and side effects (e.g., pain, lymphedema, fatigue, neuropathy), quality of life, and psychosocial functioning (e.g., anxiety, depression, self-esteem, happiness), (2) the determinants of physical activity and health-related fitness including demographic, medical, social cognitive, and environmental variables, (3) the mediators of any observed associations between physical activity, health-related fitness, and health outcomes including biological, functional, and psychosocial, and (4) the moderators of any observed associations including demographic, medical, and biological/disease factors. Taken together, these data will provide a comprehensive inquiry into the outcomes, determinants, mechanisms, and moderators of physical activity and health-related fitness in breast cancer survivors.</p>
</sec>
</div>
</front>
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<author><name sortKey="Vallance, Jeff K" sort="Vallance, Jeff K" uniqKey="Vallance J" first="Jeff K" last="Vallance">Jeff K. Vallance</name>
<affiliation wicri:level="1"><nlm:aff id="I2">Faculty of Health Disciplines, Athabasca University, Athabasca, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Faculty of Health Disciplines, Athabasca University, Athabasca</wicri:regionArea>
<wicri:noRegion>Athabasca</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Culos Reed, S Nicole" sort="Culos Reed, S Nicole" uniqKey="Culos Reed S" first="S Nicole" last="Culos-Reed">S Nicole Culos-Reed</name>
<affiliation wicri:level="4"><nlm:aff id="I3">Faculty of Kinesiology, University of Calgary, Calgary, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Faculty of Kinesiology, University of Calgary, Calgary</wicri:regionArea>
<orgName type="university">Université de Calgary</orgName>
<placeName><settlement type="city">Calgary</settlement>
<region type="state">Alberta</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mcneely, Margaret L" sort="Mcneely, Margaret L" uniqKey="Mcneely M" first="Margaret L" last="Mcneely">Margaret L. Mcneely</name>
<affiliation wicri:level="1"><nlm:aff id="I4">Faculty of Rehabilitation Medicine, University of Alberta, Edmonton, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Faculty of Rehabilitation Medicine, University of Alberta, Edmonton</wicri:regionArea>
<wicri:noRegion>Edmonton</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bell, Gordon J" sort="Bell, Gordon J" uniqKey="Bell G" first="Gordon J" last="Bell">Gordon J. Bell</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Faculty of Physical Education and Recreation, University of Alberta, Edmonton, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Faculty of Physical Education and Recreation, University of Alberta, Edmonton</wicri:regionArea>
<wicri:noRegion>Edmonton</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mackey, John R" sort="Mackey, John R" uniqKey="Mackey J" first="John R" last="Mackey">John R. Mackey</name>
<affiliation wicri:level="1"><nlm:aff id="I5">Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Faculty of Medicine and Dentistry, University of Alberta, Edmonton</wicri:regionArea>
<wicri:noRegion>Edmonton</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yasui, Yutaka" sort="Yasui, Yutaka" uniqKey="Yasui Y" first="Yutaka" last="Yasui">Yutaka Yasui</name>
<affiliation wicri:level="1"><nlm:aff id="I6">School of Public Health, University of Alberta, Edmonton, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>School of Public Health, University of Alberta, Edmonton</wicri:regionArea>
<wicri:noRegion>Edmonton</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yuan, Yan" sort="Yuan, Yan" uniqKey="Yuan Y" first="Yan" last="Yuan">Yan Yuan</name>
<affiliation wicri:level="1"><nlm:aff id="I6">School of Public Health, University of Alberta, Edmonton, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>School of Public Health, University of Alberta, Edmonton</wicri:regionArea>
<wicri:noRegion>Edmonton</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Matthews, Charles E" sort="Matthews, Charles E" uniqKey="Matthews C" first="Charles E" last="Matthews">Charles E. Matthews</name>
<affiliation wicri:level="2"><nlm:aff id="I7">Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, Maryland</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Lau, David Cw" sort="Lau, David Cw" uniqKey="Lau D" first="David Cw" last="Lau">David Cw Lau</name>
<affiliation wicri:level="4"><nlm:aff id="I8">Faculty of Medicine, University of Calgary, Calgary, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Faculty of Medicine, University of Calgary, Calgary</wicri:regionArea>
<orgName type="university">Université de Calgary</orgName>
<placeName><settlement type="city">Calgary</settlement>
<region type="state">Alberta</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cook, Diane" sort="Cook, Diane" uniqKey="Cook D" first="Diane" last="Cook">Diane Cook</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Faculty of Physical Education and Recreation, University of Alberta, Edmonton, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Faculty of Physical Education and Recreation, University of Alberta, Edmonton</wicri:regionArea>
<wicri:noRegion>Edmonton</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Friedenreich, Christine M" sort="Friedenreich, Christine M" uniqKey="Friedenreich C" first="Christine M" last="Friedenreich">Christine M. Friedenreich</name>
<affiliation wicri:level="1"><nlm:aff id="I9">Department of Epidemiology, Alberta Health Services, Calgary, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Epidemiology, Alberta Health Services, Calgary</wicri:regionArea>
<wicri:noRegion>Calgary</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">BMC Cancer</title>
<idno type="eISSN">1471-2407</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>Limited research has examined the association between physical activity, health-related fitness, and disease outcomes in breast cancer survivors. Here, we present the rationale and design of the <underline>A</underline>
lberta <underline>M</underline>
oving <underline>Be</underline>
yond B<underline>r</underline>
east Cancer (AMBER) Study, a prospective cohort study designed specifically to examine the role of physical activity and health-related fitness in breast cancer survivorship from the time of diagnosis and for the balance of life. The AMBER Study will examine the role of physical activity and health-related fitness in facilitating treatment completion, alleviating treatment side effects, hastening recovery after treatments, improving long term quality of life, and reducing the risks of disease recurrence, other chronic diseases, and premature death.</p>
</sec>
<sec><title>Methods/Design</title>
<p>The AMBER Study will enroll 1500 newly diagnosed, incident, stage I-IIIc breast cancer survivors in Alberta, Canada over a 5 year period. Assessments will be made at baseline (within 90 days of surgery), 1 year, and 3 years consisting of objective and self-reported measurements of physical activity, health-related fitness, blood collection, lymphedema, patient-reported outcomes, and determinants of physical activity. A final assessment at 5 years will measure patient-reported data only. The cohort members will be followed for an additional 5 years for disease outcomes.</p>
</sec>
<sec><title>Discussion</title>
<p>The AMBER cohort will answer key questions related to physical activity and health-related fitness in breast cancer survivors including: (1) the independent and interactive associations of physical activity and health-related fitness with disease outcomes (e.g., recurrence, breast cancer-specific mortality, overall survival), treatment completion rates, symptoms and side effects (e.g., pain, lymphedema, fatigue, neuropathy), quality of life, and psychosocial functioning (e.g., anxiety, depression, self-esteem, happiness), (2) the determinants of physical activity and health-related fitness including demographic, medical, social cognitive, and environmental variables, (3) the mediators of any observed associations between physical activity, health-related fitness, and health outcomes including biological, functional, and psychosocial, and (4) the moderators of any observed associations including demographic, medical, and biological/disease factors. Taken together, these data will provide a comprehensive inquiry into the outcomes, determinants, mechanisms, and moderators of physical activity and health-related fitness in breast cancer survivors.</p>
</sec>
</div>
</front>
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<author><name sortKey="Paice, J" uniqKey="Paice J">J Paice</name>
</author>
<author><name sortKey="Tummala, S" uniqKey="Tummala S">S Tummala</name>
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<author><name sortKey="Mcneely, M" uniqKey="Mcneely M">M McNeely</name>
</author>
<author><name sortKey="Alfano, C" uniqKey="Alfano C">C Alfano</name>
</author>
<author><name sortKey="Mayer, D" uniqKey="Mayer D">D Mayer</name>
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<pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The Alberta moving beyond breast cancer (AMBER) cohort study: a prospective study of physical activity and health-related fitness in breast cancer survivors.</title>
<author><name sortKey="Courneya, Kerry S" sort="Courneya, Kerry S" uniqKey="Courneya K" first="Kerry S" last="Courneya">Kerry S. Courneya</name>
<affiliation wicri:level="1"><nlm:affiliation>Faculty of Physical Education and Recreation, University of Alberta, Edmonton, Canada. kerry.courneya@ualberta.ca</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Faculty of Physical Education and Recreation, University of Alberta, Edmonton</wicri:regionArea>
<wicri:noRegion>Edmonton</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Vallance, Jeff K" sort="Vallance, Jeff K" uniqKey="Vallance J" first="Jeff K" last="Vallance">Jeff K. Vallance</name>
</author>
<author><name sortKey="Culos Reed, S Nicole" sort="Culos Reed, S Nicole" uniqKey="Culos Reed S" first="S Nicole" last="Culos-Reed">S Nicole Culos-Reed</name>
</author>
<author><name sortKey="Mcneely, Margaret L" sort="Mcneely, Margaret L" uniqKey="Mcneely M" first="Margaret L" last="Mcneely">Margaret L. Mcneely</name>
</author>
<author><name sortKey="Bell, Gordon J" sort="Bell, Gordon J" uniqKey="Bell G" first="Gordon J" last="Bell">Gordon J. Bell</name>
</author>
<author><name sortKey="Mackey, John R" sort="Mackey, John R" uniqKey="Mackey J" first="John R" last="Mackey">John R. Mackey</name>
</author>
<author><name sortKey="Yasui, Yutaka" sort="Yasui, Yutaka" uniqKey="Yasui Y" first="Yutaka" last="Yasui">Yutaka Yasui</name>
</author>
<author><name sortKey="Yuan, Yan" sort="Yuan, Yan" uniqKey="Yuan Y" first="Yan" last="Yuan">Yan Yuan</name>
</author>
<author><name sortKey="Matthews, Charles E" sort="Matthews, Charles E" uniqKey="Matthews C" first="Charles E" last="Matthews">Charles E. Matthews</name>
</author>
<author><name sortKey="Lau, David Cw" sort="Lau, David Cw" uniqKey="Lau D" first="David Cw" last="Lau">David Cw Lau</name>
</author>
<author><name sortKey="Cook, Diane" sort="Cook, Diane" uniqKey="Cook D" first="Diane" last="Cook">Diane Cook</name>
</author>
<author><name sortKey="Friedenreich, Christine M" sort="Friedenreich, Christine M" uniqKey="Friedenreich C" first="Christine M" last="Friedenreich">Christine M. Friedenreich</name>
</author>
</titleStmt>
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<date when="2012">2012</date>
<idno type="RBID">pubmed:23153358</idno>
<idno type="pmid">23153358</idno>
<idno type="doi">10.1186/1471-2407-12-525</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">The Alberta moving beyond breast cancer (AMBER) cohort study: a prospective study of physical activity and health-related fitness in breast cancer survivors.</title>
<author><name sortKey="Courneya, Kerry S" sort="Courneya, Kerry S" uniqKey="Courneya K" first="Kerry S" last="Courneya">Kerry S. Courneya</name>
<affiliation wicri:level="1"><nlm:affiliation>Faculty of Physical Education and Recreation, University of Alberta, Edmonton, Canada. kerry.courneya@ualberta.ca</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Faculty of Physical Education and Recreation, University of Alberta, Edmonton</wicri:regionArea>
<wicri:noRegion>Edmonton</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Vallance, Jeff K" sort="Vallance, Jeff K" uniqKey="Vallance J" first="Jeff K" last="Vallance">Jeff K. Vallance</name>
</author>
<author><name sortKey="Culos Reed, S Nicole" sort="Culos Reed, S Nicole" uniqKey="Culos Reed S" first="S Nicole" last="Culos-Reed">S Nicole Culos-Reed</name>
</author>
<author><name sortKey="Mcneely, Margaret L" sort="Mcneely, Margaret L" uniqKey="Mcneely M" first="Margaret L" last="Mcneely">Margaret L. Mcneely</name>
</author>
<author><name sortKey="Bell, Gordon J" sort="Bell, Gordon J" uniqKey="Bell G" first="Gordon J" last="Bell">Gordon J. Bell</name>
</author>
<author><name sortKey="Mackey, John R" sort="Mackey, John R" uniqKey="Mackey J" first="John R" last="Mackey">John R. Mackey</name>
</author>
<author><name sortKey="Yasui, Yutaka" sort="Yasui, Yutaka" uniqKey="Yasui Y" first="Yutaka" last="Yasui">Yutaka Yasui</name>
</author>
<author><name sortKey="Yuan, Yan" sort="Yuan, Yan" uniqKey="Yuan Y" first="Yan" last="Yuan">Yan Yuan</name>
</author>
<author><name sortKey="Matthews, Charles E" sort="Matthews, Charles E" uniqKey="Matthews C" first="Charles E" last="Matthews">Charles E. Matthews</name>
</author>
<author><name sortKey="Lau, David Cw" sort="Lau, David Cw" uniqKey="Lau D" first="David Cw" last="Lau">David Cw Lau</name>
</author>
<author><name sortKey="Cook, Diane" sort="Cook, Diane" uniqKey="Cook D" first="Diane" last="Cook">Diane Cook</name>
</author>
<author><name sortKey="Friedenreich, Christine M" sort="Friedenreich, Christine M" uniqKey="Friedenreich C" first="Christine M" last="Friedenreich">Christine M. Friedenreich</name>
</author>
</analytic>
<series><title level="j">BMC cancer</title>
<idno type="eISSN">1471-2407</idno>
<imprint><date when="2012" type="published">2012</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alberta</term>
<term>Breast Neoplasms (complications)</term>
<term>Breast Neoplasms (psychology)</term>
<term>Cohort Studies</term>
<term>Exercise</term>
<term>Female</term>
<term>Health Status</term>
<term>Humans</term>
<term>Physical Fitness</term>
<term>Quality of Life</term>
<term>Research Design</term>
<term>Self Report</term>
<term>Survivors</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Alberta</term>
<term>Aptitude physique</term>
<term>Autorapport</term>
<term>Exercice physique</term>
<term>Femelle</term>
<term>Humains</term>
<term>Plan de recherche</term>
<term>Qualité de vie</term>
<term>Survivants</term>
<term>Tumeurs du sein ()</term>
<term>Tumeurs du sein (psychologie)</term>
<term>État de santé</term>
<term>Études de cohortes</term>
</keywords>
<keywords scheme="MESH" type="geographic" xml:lang="en"><term>Alberta</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Breast Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="psychologie" xml:lang="fr"><term>Tumeurs du sein</term>
</keywords>
<keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Breast Neoplasms</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Cohort Studies</term>
<term>Exercise</term>
<term>Female</term>
<term>Health Status</term>
<term>Humans</term>
<term>Physical Fitness</term>
<term>Quality of Life</term>
<term>Research Design</term>
<term>Self Report</term>
<term>Survivors</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Alberta</term>
<term>Aptitude physique</term>
<term>Autorapport</term>
<term>Exercice physique</term>
<term>Femelle</term>
<term>Humains</term>
<term>Plan de recherche</term>
<term>Qualité de vie</term>
<term>Survivants</term>
<term>Tumeurs du sein</term>
<term>État de santé</term>
<term>Études de cohortes</term>
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<front><div type="abstract" xml:lang="en">Limited research has examined the association between physical activity, health-related fitness, and disease outcomes in breast cancer survivors. Here, we present the rationale and design of the Alberta Moving Beyond Breast Cancer (AMBER) Study, a prospective cohort study designed specifically to examine the role of physical activity and health-related fitness in breast cancer survivorship from the time of diagnosis and for the balance of life. The AMBER Study will examine the role of physical activity and health-related fitness in facilitating treatment completion, alleviating treatment side effects, hastening recovery after treatments, improving long term quality of life, and reducing the risks of disease recurrence, other chronic diseases, and premature death.</div>
</front>
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