Histopathological analysis of vesicular and bullous lesions in Kaposi sarcoma
Identifieur interne : 005042 ( Ncbi/Merge ); précédent : 005041; suivant : 005043Histopathological analysis of vesicular and bullous lesions in Kaposi sarcoma
Auteurs : Nilüfer Onak Kandemir [Turquie] ; Figen Barut [Turquie] ; Banu Do An Gün [Turquie] ; Nilgün Solak Tekin [Turquie] ; Sevinç Hallaç Keser [Turquie] ; Krü O Uz Özdamar [Turquie]Source :
- Diagnostic Pathology [ 1746-1596 ] ; 2012.
Abstract
In this study, the clinical and morphological features of vesiculobullous lesions observed in Kaposi sarcoma are analyzed, and the features of bullous Kaposi sarcoma cases are emphasized.
A total of 178 biopsy materials of 75 cases diagnosed as classic-type cutaneous Kaposi sarcoma were reviewed. Twenty-five cases showing vesiculobullous features were included in the study. Tumor, epidermis, dermis, and clinical data regarding these cases was evaluated.
Vesicular changes were observed in 21 (12%) out of 178 lesions of the 75 cases, while bullous changes were present in only 4 (2%). In all cases where vesicular and bullous changes were detected, tumor, epidermis, and dermis changes were similar. All cases were nodular stage KS lesions, whereas hyperkeratosis and serum exudation in the epidermis, marked edema in the dermis, and enlarged lymphatic vessels and chronic inflammatory response were observed.
Our findings suggest that changes in vascular resistance occurring during tumor progression are the most important factors comprising vesiculobullous morphology.
The virtual slide(s) for this article can be found here:
Url:
DOI: 10.1186/1746-1596-7-101
PubMed: 22894735
PubMed Central: 3488507
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PMC:3488507Le document en format XML
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<author><name sortKey="Ozdamar, Kru O Uz" sort="Ozdamar, Kru O Uz" uniqKey="Ozdamar " first=" Krü O Uz" last="Özdamar"> Krü O Uz Özdamar</name>
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<author><name sortKey="Barut, Figen" sort="Barut, Figen" uniqKey="Barut F" first="Figen" last="Barut">Figen Barut</name>
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<author><name sortKey="Ozdamar, Kru O Uz" sort="Ozdamar, Kru O Uz" uniqKey="Ozdamar " first=" Krü O Uz" last="Özdamar"> Krü O Uz Özdamar</name>
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<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>In this study, the clinical and morphological features of vesiculobullous lesions observed in Kaposi sarcoma are analyzed, and the features of bullous Kaposi sarcoma cases are emphasized.</p>
</sec>
<sec><title>Methods</title>
<p>A total of 178 biopsy materials of 75 cases diagnosed as classic-type cutaneous Kaposi sarcoma were reviewed. Twenty-five cases showing vesiculobullous features were included in the study. Tumor, epidermis, dermis, and clinical data regarding these cases was evaluated.</p>
</sec>
<sec><title>Results</title>
<p>Vesicular changes were observed in 21 (12%) out of 178 lesions of the 75 cases, while bullous changes were present in only 4 (2%). In all cases where vesicular and bullous changes were detected, tumor, epidermis, and dermis changes were similar. All cases were nodular stage KS lesions, whereas hyperkeratosis and serum exudation in the epidermis, marked edema in the dermis, and enlarged lymphatic vessels and chronic inflammatory response were observed.</p>
</sec>
<sec><title>Conclusions</title>
<p>Our findings suggest that changes in vascular resistance occurring during tumor progression are the most important factors comprising vesiculobullous morphology.</p>
</sec>
<sec><title>Virtual slides</title>
<p>The virtual slide(s) for this article can be found here:
<ext-link ext-link-type="uri" xlink:href="http://www.diagnosticpathology.diagnomx.eu/vs/1646397188748474">http://www.diagnosticpathology.diagnomx.eu/vs/1646397188748474</ext-link>
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<front><journal-meta><journal-id journal-id-type="nlm-ta">Diagn Pathol</journal-id>
<journal-id journal-id-type="iso-abbrev">Diagn Pathol</journal-id>
<journal-title-group><journal-title>Diagnostic Pathology</journal-title>
</journal-title-group>
<issn pub-type="epub">1746-1596</issn>
<publisher><publisher-name>BioMed Central</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">22894735</article-id>
<article-id pub-id-type="pmc">3488507</article-id>
<article-id pub-id-type="publisher-id">1746-1596-7-101</article-id>
<article-id pub-id-type="doi">10.1186/1746-1596-7-101</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Research</subject>
</subj-group>
</article-categories>
<title-group><article-title>Histopathological analysis of vesicular and bullous lesions in Kaposi sarcoma</article-title>
</title-group>
<contrib-group><contrib contrib-type="author" corresp="yes" id="A1"><name><surname>Kandemir</surname>
<given-names>Nilüfer Onak</given-names>
</name>
<xref ref-type="aff" rid="I1">1</xref>
<email>niluferkandemir@yahoo.com</email>
</contrib>
<contrib contrib-type="author" id="A2"><name><surname>Barut</surname>
<given-names>Figen</given-names>
</name>
<xref ref-type="aff" rid="I1">1</xref>
<email>figenbarut@yahoo.com</email>
</contrib>
<contrib contrib-type="author" id="A3"><name><surname>Gün</surname>
<given-names>Banu Doğan</given-names>
</name>
<xref ref-type="aff" rid="I1">1</xref>
<email>bunudogangun@yahoo.com</email>
</contrib>
<contrib contrib-type="author" id="A4"><name><surname>Tekin</surname>
<given-names>Nilgün Solak</given-names>
</name>
<xref ref-type="aff" rid="I2">2</xref>
<email>nilgunsolaktekin@yahoo.com</email>
</contrib>
<contrib contrib-type="author" id="A5"><name><surname>Keser</surname>
<given-names>Sevinç Hallaç</given-names>
</name>
<xref ref-type="aff" rid="I3">3</xref>
<email>sevinckeser@yahoo.com</email>
</contrib>
<contrib contrib-type="author" id="A6"><name><surname>Özdamar</surname>
<given-names>Şükrü Oğuz</given-names>
</name>
<xref ref-type="aff" rid="I1">1</xref>
<email>sukruouzozdamar@yahoo.com</email>
</contrib>
</contrib-group>
<aff id="I1"><label>1</label>
Department of Pathology, Karaelmas University, Faculty of Medicine, Zonguldak, Turkey</aff>
<aff id="I2"><label>2</label>
Department of Dermathology, Karaelmas University, Faculty of Medicine, Zonguldak, Turkey</aff>
<aff id="I3"><label>3</label>
Department of Pathology, Lütfi Kirdar Kartal Training and Research Hospital, Istanbul, Turkey</aff>
<pub-date pub-type="collection"><year>2012</year>
</pub-date>
<pub-date pub-type="epub"><day>15</day>
<month>8</month>
<year>2012</year>
</pub-date>
<volume>7</volume>
<fpage>101</fpage>
<lpage>101</lpage>
<history><date date-type="received"><day>13</day>
<month>6</month>
<year>2012</year>
</date>
<date date-type="accepted"><day>5</day>
<month>8</month>
<year>2012</year>
</date>
</history>
<permissions><copyright-statement>Copyright ©2012 Kandemir et al.; licensee BioMed Central Ltd.</copyright-statement>
<copyright-year>2012</copyright-year>
<copyright-holder>Kandemir et al.; licensee BioMed Central Ltd.</copyright-holder>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/2.0"><license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution License (
<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/2.0">http://creativecommons.org/licenses/by/2.0</ext-link>
), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
</license>
</permissions>
<self-uri xlink:href="http://www.diagnosticpathology.org/content/7/1/101"></self-uri>
<abstract><sec><title>Background</title>
<p>In this study, the clinical and morphological features of vesiculobullous lesions observed in Kaposi sarcoma are analyzed, and the features of bullous Kaposi sarcoma cases are emphasized.</p>
</sec>
<sec><title>Methods</title>
<p>A total of 178 biopsy materials of 75 cases diagnosed as classic-type cutaneous Kaposi sarcoma were reviewed. Twenty-five cases showing vesiculobullous features were included in the study. Tumor, epidermis, dermis, and clinical data regarding these cases was evaluated.</p>
</sec>
<sec><title>Results</title>
<p>Vesicular changes were observed in 21 (12%) out of 178 lesions of the 75 cases, while bullous changes were present in only 4 (2%). In all cases where vesicular and bullous changes were detected, tumor, epidermis, and dermis changes were similar. All cases were nodular stage KS lesions, whereas hyperkeratosis and serum exudation in the epidermis, marked edema in the dermis, and enlarged lymphatic vessels and chronic inflammatory response were observed.</p>
</sec>
<sec><title>Conclusions</title>
<p>Our findings suggest that changes in vascular resistance occurring during tumor progression are the most important factors comprising vesiculobullous morphology.</p>
</sec>
<sec><title>Virtual slides</title>
<p>The virtual slide(s) for this article can be found here:
<ext-link ext-link-type="uri" xlink:href="http://www.diagnosticpathology.diagnomx.eu/vs/1646397188748474">http://www.diagnosticpathology.diagnomx.eu/vs/1646397188748474</ext-link>
</p>
</sec>
</abstract>
<kwd-group><kwd>Kaposi sarcoma</kwd>
<kwd>Bullous Kaposi sarcoma</kwd>
<kwd>Histological variants</kwd>
<kwd>Lymphangioma-like Kaposi sarcoma</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>Turquie</li>
</country>
</list>
<tree><country name="Turquie"><noRegion><name sortKey="Kandemir, Nilufer Onak" sort="Kandemir, Nilufer Onak" uniqKey="Kandemir N" first="Nilüfer Onak" last="Kandemir">Nilüfer Onak Kandemir</name>
</noRegion>
<name sortKey="Barut, Figen" sort="Barut, Figen" uniqKey="Barut F" first="Figen" last="Barut">Figen Barut</name>
<name sortKey="Gun, Banu Do An" sort="Gun, Banu Do An" uniqKey="Gun B" first="Banu Do An" last="Gün">Banu Do An Gün</name>
<name sortKey="Keser, Sevinc Hallac" sort="Keser, Sevinc Hallac" uniqKey="Keser S" first="Sevinç Hallaç" last="Keser">Sevinç Hallaç Keser</name>
<name sortKey="Ozdamar, Kru O Uz" sort="Ozdamar, Kru O Uz" uniqKey="Ozdamar " first=" Krü O Uz" last="Özdamar"> Krü O Uz Özdamar</name>
<name sortKey="Tekin, Nilgun Solak" sort="Tekin, Nilgun Solak" uniqKey="Tekin N" first="Nilgün Solak" last="Tekin">Nilgün Solak Tekin</name>
</country>
</tree>
</affiliations>
</record>
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