Peripheral T-cell Lymphoma with Cyclin D1 overexpression: a case report
Identifieur interne : 004F24 ( Ncbi/Merge ); précédent : 004F23; suivant : 004F25Peripheral T-cell Lymphoma with Cyclin D1 overexpression: a case report
Auteurs : Gabriella Aquino [Italie] ; Renato Franco [Italie] ; Fioravante Ronconi [Italie] ; Annamaria Anniciello [Italie] ; Luigi Russo [Italie] ; Annarosaria De Chiara [Italie] ; Luigi Panico [Italie]Source :
- Diagnostic Pathology [ 1746-1596 ] ; 2012.
Abstract
Peripheral T-cell lymphomas not otherwise specified are generally considered aggressive non-Hodgkin lymphomas, because of poor natural outcome and response to therapy. They show a complex karyotype without any specific genetic hallmark. We report a case of peripheral T-cell lymphoma not otherwise specified with heterogeneous nuclear Cyclin D1 immunohistochemical overexpression, due to gene copy gain, a phenomenon similar to that observed in Mantle Cell Lymphoma characterized by t(11;14)(q13;q32). In this case report we underline the diagnostic pitfall rapresented by Cyclin D1 immunoistochemical overexpression in a T-cell lymphoma. Several pitfalls could lead to misinterpretation of diagnosis, therefore, we underlined the need to integrate the classical histology and immunohistochemistry with molecular tests as clonality or Fluorescence in situ hybridization.
The virtual slides for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1117747619703769
Url:
DOI: 10.1186/1746-1596-7-79
PubMed: 22770229
PubMed Central: 3475098
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Panico</name><affiliation wicri:level="1"><nlm:aff id="I4">Pathology Unit, Hospital “S.G .Moscati”, Contrada Amoretta, 83100, Avellino, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Pathology Unit, Hospital “S.G .Moscati”, Contrada Amoretta, 83100, Avellino</wicri:regionArea><wicri:noRegion>Avellino</wicri:noRegion></affiliation></author></analytic><series><title level="j">Diagnostic Pathology</title><idno type="eISSN">1746-1596</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Peripheral T-cell lymphomas not otherwise specified are generally considered aggressive non-Hodgkin lymphomas, because of poor natural outcome and response to therapy. They show a complex karyotype without any specific genetic hallmark. We report a case of peripheral T-cell lymphoma not otherwise specified with heterogeneous nuclear Cyclin D1 immunohistochemical overexpression, due to gene copy gain, a phenomenon similar to that observed in Mantle Cell Lymphoma characterized by t(11;14)(q13;q32). In this case report we underline the diagnostic pitfall rapresented by Cyclin D1 immunoistochemical overexpression in a T-cell lymphoma. Several pitfalls could lead to misinterpretation of diagnosis, therefore, we underlined the need to integrate the classical histology and immunohistochemistry with molecular tests as clonality or Fluorescence in situ hybridization.</p><sec><title>Virtual slide</title><p>The virtual slides for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1117747619703769</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Vose, J" uniqKey="Vose J">J Vose</name></author><author><name sortKey="Armitage, J" uniqKey="Armitage J">J Armitage</name></author><author><name sortKey="Weisenburger, D" uniqKey="Weisenburger D">D Weisenburger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rudiger, T" uniqKey="Rudiger T">T Rüdiger</name></author><author><name sortKey="Weisenburger, Dd" uniqKey="Weisenburger D">DD Weisenburger</name></author><author><name sortKey="Anderson, Jr" 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Diagn Pathol</journal-id><journal-id journal-id-type="iso-abbrev">Diagn Pathol</journal-id><journal-title-group><journal-title>Diagnostic Pathology</journal-title></journal-title-group><issn pub-type="epub">1746-1596</issn><publisher><publisher-name>BioMed Central</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">22770229</article-id><article-id pub-id-type="pmc">3475098</article-id><article-id pub-id-type="publisher-id">1746-1596-7-79</article-id><article-id pub-id-type="doi">10.1186/1746-1596-7-79</article-id><article-categories><subj-group subj-group-type="heading"><subject>Case Report</subject></subj-group></article-categories><title-group><article-title>Peripheral T-cell Lymphoma with Cyclin D1 overexpression: a case report</article-title></title-group><contrib-group><contrib contrib-type="author" id="A1"><name><surname>Aquino</surname><given-names>Gabriella</given-names></name><xref ref-type="aff" rid="I1">1</xref><email>gabryaquino@libero.it</email></contrib><contrib contrib-type="author" corresp="yes" id="A2"><name><surname>Franco</surname><given-names>Renato</given-names></name><xref ref-type="aff" rid="I1">1</xref><email>r.franco@istitutotumori.na.it</email></contrib><contrib contrib-type="author" id="A3"><name><surname>Ronconi</surname><given-names>Fioravante</given-names></name><xref ref-type="aff" rid="I2">2</xref><xref ref-type="aff" rid="I3">3</xref><email>fioroncon@interfree.it</email></contrib><contrib contrib-type="author" id="A4"><name><surname>Anniciello</surname><given-names>Annamaria</given-names></name><xref ref-type="aff" rid="I1">1</xref><email>a.anniciello@istitutotumori.na.it</email></contrib><contrib contrib-type="author" id="A5"><name><surname>Russo</surname><given-names>Luigi</given-names></name><xref ref-type="aff" rid="I1">1</xref><email>l.russo@istitutotumori.na.it</email></contrib><contrib contrib-type="author" id="A6"><name><surname>De Chiara</surname><given-names>Annarosaria</given-names></name><xref ref-type="aff" rid="I1">1</xref><email>a.dechiara@istitutotumori.na.it</email></contrib><contrib contrib-type="author" id="A7"><name><surname>Panico</surname><given-names>Luigi</given-names></name><xref ref-type="aff" rid="I4">4</xref><email>giginic@libero.it</email></contrib></contrib-group><aff id="I1"><label>1</label>Pathology Unit, National Cancer Institute “Fondazione Giovanni Pascale”, Via Mariano Semmola, 80131, Napoli, Italy</aff><aff id="I2"><label>2</label>Hematology Unit, Hospital “S.G .Moscati”, Contrada Amoretta, 83100, Avellino, Italy</aff><aff id="I3"><label>3</label>Hematology Unit, Hospital “Caradarelli”, Naples, Italy</aff><aff id="I4"><label>4</label>Pathology Unit, Hospital “S.G .Moscati”, Contrada Amoretta, 83100, Avellino, Italy</aff><pub-date pub-type="collection"><year>2012</year></pub-date><pub-date pub-type="epub"><day>6</day><month>7</month><year>2012</year></pub-date><volume>7</volume><fpage>79</fpage><lpage>79</lpage><history><date date-type="received"><day>28</day><month>3</month><year>2012</year></date><date date-type="accepted"><day>21</day><month>5</month><year>2012</year></date></history><permissions><copyright-statement>Copyright ©2012 Aquino et al.; licensee BioMed Central Ltd.</copyright-statement><copyright-year>2012</copyright-year><copyright-holder>Aquino et al.; licensee BioMed Central Ltd.</copyright-holder><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/2.0"><license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/2.0">http://creativecommons.org/licenses/by/2.0</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><self-uri xlink:href="http://www.diagnosticpathology.org/content/7/1/79"></self-uri><abstract><p>Peripheral T-cell lymphomas not otherwise specified are generally considered aggressive non-Hodgkin lymphomas, because of poor natural outcome and response to therapy. They show a complex karyotype without any specific genetic hallmark. We report a case of peripheral T-cell lymphoma not otherwise specified with heterogeneous nuclear Cyclin D1 immunohistochemical overexpression, due to gene copy gain, a phenomenon similar to that observed in Mantle Cell Lymphoma characterized by t(11;14)(q13;q32). In this case report we underline the diagnostic pitfall rapresented by Cyclin D1 immunoistochemical overexpression in a T-cell lymphoma. Several pitfalls could lead to misinterpretation of diagnosis, therefore, we underlined the need to integrate the classical histology and immunohistochemistry with molecular tests as clonality or Fluorescence in situ hybridization.</p><sec><title>Virtual slide</title><p>The virtual slides for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1117747619703769</p></sec></abstract><kwd-group><kwd>CCND1 copy gain</kwd><kwd>Cyclin D1 over-expression</kwd><kwd>Peripheral T-cell lymphoma</kwd><kwd>FISH</kwd></kwd-group></article-meta></front></pmc><affiliations><list><country><li>Italie</li></country></list><tree><country name="Italie"><noRegion><name sortKey="Aquino, Gabriella" sort="Aquino, Gabriella" uniqKey="Aquino G" first="Gabriella" last="Aquino">Gabriella Aquino</name></noRegion><name sortKey="Anniciello, Annamaria" sort="Anniciello, Annamaria" uniqKey="Anniciello A" first="Annamaria" last="Anniciello">Annamaria Anniciello</name><name sortKey="De Chiara, Annarosaria" sort="De Chiara, Annarosaria" uniqKey="De Chiara A" first="Annarosaria" last="De Chiara">Annarosaria De Chiara</name><name sortKey="Franco, Renato" sort="Franco, Renato" uniqKey="Franco R" first="Renato" last="Franco">Renato Franco</name><name sortKey="Panico, Luigi" sort="Panico, Luigi" uniqKey="Panico L" first="Luigi" last="Panico">Luigi Panico</name><name sortKey="Ronconi, Fioravante" sort="Ronconi, Fioravante" uniqKey="Ronconi F" first="Fioravante" last="Ronconi">Fioravante Ronconi</name><name sortKey="Ronconi, Fioravante" sort="Ronconi, Fioravante" uniqKey="Ronconi F" first="Fioravante" last="Ronconi">Fioravante Ronconi</name><name sortKey="Russo, Luigi" sort="Russo, Luigi" uniqKey="Russo L" first="Luigi" last="Russo">Luigi Russo</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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